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Rongwang Yang, Yanyi Zhang, Weijia Gao, Nannan Lin, Rong Li, Zhengyan Zhao
Some trace elements may participate in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). This study aimed to investigate the trace element status of zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg), and lead (Pb) in children with ADHD, and to compare them with normal controls. Associations between examined elements and SNAP-IV rating scores of ADHD symptoms were also assessed. Four hundred nineteen children with ADHD (8.8 ± 2.1 years) and 395 matched normal controls (8.9 ± 1.7 years) were recruited in the study...
June 16, 2018: Biological Trace Element Research
Bo Lou, Ans De Beuckelaer, George R Dakwar, Katrien Remaut, Johan Grooten, Kevin Braeckmans, Bruno G De Geest, Enrico Mastrobattista, Stefaan De Koker, Wim E Hennink
Potent adjuvants are highly demanded for most protein and peptides based vaccine candidates in clinical development. Recognition of viral single stranded (ss)RNA by innate toll-like receptors 7/8 in dendritic cells results in a cytokine environment supportive to the establishment of long lasting antibody responses and Th1 oriented T cell immunity. To fully exploit the immunestimulatory properties of ssRNA, it needs to be adequately formulated to ensure its optimal delivery to dendritic cells in the vaccine draining lymph nodes...
June 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
OBJECTIVES: This study included 51 osteoporosis patients with rheumatoid arthritis (RA) who were treated with anti-resorption drug, denosumab. To date, there has been no report on the changes of bone-related minerals after anti-resorption drug therapy. METHODS: Fifty one osteoporotic patients with RA were retrospectively enrolled. Serum Zinc (Zn), Magnesium (Mg), Iron (Fe), and Copper (Cu) were examined at 1 week, 1, 2, 4, 6, 8, 10, 12 months. Lumbar spine (L1-4) bone mineral density (L-BMD), and bilateral total hip BMD (H-BMD) were examined before and at 6 and 12 months after treatment commencement...
August 2018: Clinical Nutrition ESPEN
Zohreh Parsaee, Nima Karachi, Razieh Razavi
This work introduces novel selective and sensitive optical sensor based on a nano sized triazine based Schiff base (H2 L) immbolized on a transparent glass substrate through the sol-gel process to detection of copper (II) ions in aqueous solutions. This sensor can determine the copper (II) in the range of 8.54 × 10-8 -1.0 × 10-5  mol L-1 with a low detection limit of 1.53 × 10-8  mol L-1 . The optimized geometry of H2 L and its copper complex was obtained based on DFT/B3LYP levels of theory with B3LYP/6-311 + G(d,p) and LANL2DZ/6-311 + G(d,p) basis sets respectively...
October 2018: Ultrasonics Sonochemistry
Martina Pilloni, Vijay Bhooshan Kumar, Guido Ennas, Ze'ev Porat, Alessandra Scano, Valentina Cabras, Aharon Gedanken
Concentrated suspensions of silver and copper salts in silicone oil were heated to 200 °C and irradiated with ultrasonic energy for different time durations. Characterization of the products was done using X-ray powder diffraction. In most cases, metallic Ag or Cu were obtained, together with their oxide forms Ag2 O and Cu2 O. The salts, used as precursors, do not dissolve in silicone oil but rather form a heterogeneous system, and we assume that local heating, caused by the acoustic cavitation, enhanced their thermal decomposition and the formation of metallic particles...
October 2018: Ultrasonics Sonochemistry
Arash Asfaram, Mehrorang Ghaedi, Hamedreza Javadian, Alireza Goudarzi
A simple, rapid, and efficient method of dispersive micro solid phase extraction (D-μ-SPE) combined with UV-Vis spectrophotometry via ultrasound-assisted (UA) was applied for the determination and preconcentration of quercetin in extract of watercress (Nasturtium officinale), fruit juice and water samples. The sorbent in this method was synthesized by doping copper and sulfide into the tetragonal structure of SnO2 -nanoparticles (Cu- and S- @SnO2 -NPs) and subsequently loading it on activated carbon (AC). The D-μ-SPE parameters with direct effect on the extraction efficiency of the targeted analyte, such as sample pH, volume of eluent, sorbent mass and ultrasound time were optimized using central composite design method...
October 2018: Ultrasonics Sonochemistry
Mihaela Badea, Octavio P Luzardo, Ana González-Antuña, Manuel Zumbado, Liliana Rogozea, Laura Floroian, Dana Alexandrescu, Marius Moga, Laura Gaman, Mariana Radoi, Luis D Boada, Luis Alberto Henríquez-Hernández
Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements...
June 13, 2018: Environmental Research
Dan Ping Wang, Maosen Fu, Yuan Ha, Hao Wang, Renbing Wu
A mesoporous octahedral copper oxide@titania (CuO/TiO2 ) composites with core-shelled structure have been successfully fabricated via a facile and cost-effective approach, which involves two main steps: the creation of homogeneous TiO2 shell onto the octahedral Cu-based metal-organic frameworks (MOFs) template and thermal decomposition of the template at controlled temperature in the air. The design of combining CuO with the TiO2 layer within a porous octahedra structure is beneficial to integrate the advantages of different components and address the severe volume change associated with pulverization issue that exists in most metal oxides-based electrodes...
June 8, 2018: Journal of Colloid and Interface Science
Souhir Abdelkrim, Salwa Harzalli Jebara, Omar Saadani, Moez Jebara
The ability of Plant Growth Promoting Rhizobateria (PGPR) to enhance Lathyrus sativus tolerance to lead (Pb) stress was investigated. Ten consortia formed by mixing four efficient and Pb-resistant PGPR strains were assessed for their beneficial effect in improving Pb (0.5 mM) uptake and in inducing host-defensive system of L. sativus under hydroponic conditions based on various physiological and biochemical parameters. Pb stress significantly decreased shoot and root dry weight but inoculation improves these biomasses with highest increases registred in SDW and RDW of plants inoculated with I5 (R...
June 15, 2018: Plant Biology
Stefano Cinti, Vincenzo Mazzaracchio, Gökçe Öztürk, Danila Moscone, Fabiana Arduini
The development of portable and user-friendly sensing platforms is a hot topic in the field of analytical chemistry. Among others, electroanalytical approaches exhibit a high amenability for reaching this purpose, i.e. the commercial strips for diabetes care are an obvious success. However, providing fully-integrated and user-friendly methods is the leitmotiv. In this work we evaluate the use of a disposable pipette tip, opportunely configured, to realize the first example of lab-on-a-tip. The combination of a pipette tip, wire electrodes, and cotton wool filter, highlights the suitability of producing a novel one-shot electroanalytical platform that does not require expertise-required tasks...
October 31, 2018: Analytica Chimica Acta
Yun Zhang, Dongmei Wang, Wei Wei, Xuejun Zeng
BACKGROUND: Wilson's disease (WD) is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in the liver and brain. Systemic lupus erythematosus (SLE) is a multi-system disorder that can manifest in any system. Cases with concomitant WD and SLE, unrelated to treatment with penicillamine, have been rarely reported. CASE PRESENTATION: We report a case of a young woman who had typical neuropsychiatric symptoms and laboratory tests results of WD...
June 15, 2018: BMC Neurology
Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Malachy McCann, Andrew Kellett, Orla Howe, Kevin Kavanagh
Herein we report the in-vivo characterisation and metabolic changes in Galleria mellonella larvae to a series of bis-chelate copper(II) phenanthroline-phenazine cationic complexes of [Cu(phen)2 ]2+ (Cu-Phen), [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen) and [Cu(DPPZ)(Phen)]2+ (Cu-DPPZ-Phen) (where phen = 1,10-phenanthroline, DPQ = dipyrido[3,2-ƒ:2',3'-h]quinoxaline and DPPZ = dipyrido[3,2-a:2',3'-c]phenazine). Our aim was to investigate the influence of the systematic extension of the ligated phenazine ligand in the G...
June 1, 2018: Journal of Inorganic Biochemistry
Anna Banasiak, John Cassidy, John Colleran
To date, DNA cleavage, caused by cleavage agents, has been monitored mainly by gel and capillary electrophoresis. However, these techniques are time-consuming, non-quantitative and require gel stains. In this work, a novel, simple and, importantly, a quantitative method for monitoring the DNA nuclease activity of potential anti-cancer drugs, at a DNA electrochemical sensor, is presented. The DNA sensors were prepared using thiol-modified oligonucleotides that self-assembled to create a DNA monolayer at gold electrode surfaces...
June 1, 2018: Biosensors & Bioelectronics
Branka Popović, Milica Velimirović, Tihomir Stojković, Gavrilo Brajović, Silvio R De Luka, Ivan Milovanović, Srdjan Stefanović, Dragica Nikolić, Jasna L Ristić-Djurović, Nataša D Petronijević, Alexander M Trbovich
Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, heart, skin, and intestine...
June 12, 2018: Experimental Gerontology
James B Hilton, Kai Kysenius, Anthony R White, Peter J Crouch
Mutations to the copper-dependent enzyme Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans, and transgenic overexpression of mutant SOD1 represents a robust murine model of the disease. We have previously shown that the copper-containing compound CuII (atsm) phenotypically improves mutant SOD1 mice and delivers copper to copper-deficient SOD1 in the CNS to restore its physiological function. CuII (atsm) is now in clinical trials for the treatment of ALS. In this study, we demonstrate that cuproenzyme dysfunction extends beyond SOD1 in SOD1G37R mice to also affect the endogenous copper-dependent ferroxidase ceruloplasmin...
June 12, 2018: Experimental Neurology
Matthew Paeth, William Carson, Jheng-Hua Luo, David L Tierney, Mu-Jeng Cheng, Zhi Cao, Wei Liu
Trifluoromethyl-containing compounds play a significant role in medicinal chemistry, materials and fine chemistry. Although direct C-H trifluoromethylation has been achieved on Csp2-H bonds, direct conversion of Csp3-H bonds to Csp3-CF3 remains challenging. We report herein an efficient protocol for the selective trifluoromethylation of benzylic C-H bonds. This process is mediated by a combination CuIII-CF3 species and persulfate salts. A wide range of methylarenes can be selectively trifluoromethylated at the benzylic positions...
June 15, 2018: Chemistry: a European Journal
Eva Rivera-Chao, Martín Fañanás-Mastral
An efficient method to access diversely substituted borylated dendralenes from simple and readily available materials is reported. This methodology is based on a multicomponent copper-catalyzed allylboration of alkynes with diboron and a 1,4-dibromo-2-butene which provides bromo- and boron-substituted skipped dienes with a remarkable chemo-, stereo- and regioselectivity. These products can be easily transformed into dendralenic organoboronates which display an extremely versatile reactivity as demonstrated by novel selective transformations...
June 15, 2018: Angewandte Chemie
O Karikari-Yeboah, W Skinner, J Addai-Mensah
Trace metals occur at various concentrations in all wetlands. Their proliferation, chemical speciation, mobility and bioavailability are dependent on the redox potential (Eh), pH and the presence of organic and inorganic adsorption surfaces and co-precipitating metals. Consequently, changes in these key parameters have the potential to alter the fate of the dominant trace metal species in the sediment. An imposition of preload surcharge is a technique use in geotechnical engineering to improve in the strength and load carrying capacity of waterlogged sediments...
June 14, 2018: Environmental Monitoring and Assessment
T A Adagunodo, L A Sunmonu, M E Emetere
In this article, the heavy metals in soils for agricultural activities were analyzed statistically. Ten (10) soil samples were randomly taken across the agricultural zones in Odo-Oba, southwestern Nigeria. Ten (10) metals; namely: copper (Cu), lead (Pb), chromium (Cr), arsenic (As), zinc (Zn), cadmium (Cd), nickel (Ni), antimony (Sb), cobalt (Co) and vanadium (V) were determined and compared with the guideline values. When the values were compared with the international standard, none of the heavy metals in the study area exceeded the threshold limit...
June 2018: Data in Brief
T B Khlebnikova, V N Konev, Z P Pai
The data presented here are related to the research paper entitled "Levopimaric Acid Derived 1,2-Diamines and Their Application in the Copper-Catalyzed Asymmetric Henry Reaction" [1]. In this data article, we provide 1 H, 13 C NMR and IR data for the diterpene derivatives described in [1]. The GC-MS analysis of pine oleoresin used as a starting material of the syntheses is also included in the data article.
June 2018: Data in Brief
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