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Allergy and cardiovascular disease

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https://www.readbyqxmd.com/read/27902485/impacts-of-cigarette-smoking-on-immune-responsiveness-up-and-down-or-upside-down
#1
REVIEW
Feifei Qiu, Chun-Ling Liang, Huazhen Liu, Yu-Qun Zeng, Shaozhen Hou, Song Huang, Xiaoping Lai, Zhenhua Dai
Cigarette smoking is associated with numerous diseases and poses a serious challenge to the current healthcare system worldwide. Smoking impacts both innate and adaptive immunity and plays dual roles in regulating immunity by either exacerbation of pathogenic immune responses or attenuation of defensive immunity. Adaptive immune cells affected by smoking mainly include T helper cells (Th1/Th2/Th17), CD4+CD25+ regulatory T cells, CD8+ T cells, B cells and memory T/B lymphocytes while innate immune cells impacted by smoking are mostly DCs, macrophages and NK cells...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27853717/amiata-donkey-milk-chain-animal-health-evaluation-and-milk-quality
#2
Giuseppe Ragona, Franco Corrias, Martina Benedetti, Maria Paladini, Federica Salari, Lolanda Altomonte, Mina Martini
This study presents an investigation of Amiata donkey health and quality of milk for human consumption. Thirty-one lactating dairy jennies were examined. The following samples were collected: faecal samples from the rectum of animals for parasitological examination; cervical swabs for the detection of bacteria causing reproductive disorders; and blood samples for serological diagnosis of main zoonotic (Brucella spp., Leptospira spp.) and donkey abortion agents (Brucella spp., Leptospira spp., Salmonella abortus equi, Equine viral arterithis virus, Equine herpesvirus type 1)...
June 3, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27771048/increasing-comorbidities-suggest-that-atopic-dermatitis%C3%A2-is%C3%A2-a%C3%A2-systemic-disorder
#3
Patrick M Brunner, Jonathan I Silverberg, Emma Guttman-Yassky, Amy S Paller, Kenji Kabashima, Masayuki Amagai, Thomas A Luger, Mette Deleuran, Thomas Werfel, Kilian Eyerich, Georg Stingl
Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies...
October 20, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27766811/myopathy-effect-of-vitamin-d-deficiency-beyond-bones
#4
Kavita J Rawat, Nilakshi H Sabnis, Udit Saraf, Gaurav Surana
Vitamin D functions as a vitamin as well as a hormone. Its major skeletal actions are complemented by varied extra-skeletal functions. During the past decade, association between Vitamin D and its role in various non-skeletal morbidities have been recognized. It plays a role in decreasing the risk of many chronic illnesses like allergies, asthma, autoimmune diseases, diabetes, cancers, infections and cardiovascular disease. We report the case of a middle aged female with chronic quadriparesis and new onset anemia associated with Vitamin D deficiency...
October 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27694038/targeting-mast-cells-uncovering-prolific-therapeutic-role-in-myriad-diseases
#5
Jatinder Singh, Ramanpreet Shah, Dhandeep Singh
The mast cells are integral part of immune system and they have pleiotropic physiological functions in our body. Any type of abnormal stimuli causes the mast cells receptors to spur the otherwise innocuous mast cells to degranulate and release inflammatory mediators like histamine, cytokines, chemokines and prostaglandins. These mediators are involved in various diseases like allergy, asthma, mastocytosis, cardiovascular disorders, etc. Herein, we describe the receptors involved in degranulation of mast cells and are broadly divided into four categories: G-protein coupled receptors, ligand gated ion channels, immunoreceptors and pattern recognition receptors...
September 29, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27677312/birth-weight-in-relation-to-health-and-disease-in-later-life-an-umbrella-review-of-systematic-reviews-and-meta-analyses
#6
Lazaros Belbasis, Makrina D Savvidou, Chidimma Kanu, Evangelos Evangelou, Ioanna Tzoulaki
BACKGROUND: Birth weight, a marker of the intrauterine environment, has been extensively studied in epidemiological research in relation to subsequent health and disease. Although numerous meta-analyses have been published examining the association between birth weight and subsequent health-related outcomes, the epidemiological credibility of these associations has not been thoroughly assessed. The objective of this study is to map the diverse health outcomes associated with birth weight and evaluate the credibility and presence of biases in the reported associations...
September 28, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27671827/garcinol-and-its-role-in-chronic-diseases
#7
Amit K Behera, Mahadeva M Swamy, Nagashayana Natesh, Tapas K Kundu
The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature. Garcinol, a polyisoprenylated benzophenone, obtained from plant Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo. Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27606613/influence-of-preoperative-oral-rehydration-on-arterial-plasma-rocuronium-concentrations-and-neuromuscular-blocking-effects-a-randomised-controlled-trial
#8
Sayaka Ishigaki, Takahiro Ogura, Ayana Kanaya, Yu Miyake, Kenichi Masui, Tomiei Kazama
BACKGROUND: The influence of preoperative rehydration on the action of rocuronium has not yet been investigated. OBJECTIVE: The objective is to evaluate the hypothesis that preoperative rehydration lowers arterial rocuronium plasma concentrations and changes its associated neuromuscular blocking effects during induction of anaesthesia. DESIGN: Randomised, single-blinded study. SETTING: A secondary hospital from October 2013 to July 2014...
January 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27425644/triggers-risk-factors-and-clinico-pathological-features-of-urticaria-in-dogs-a-prospective-observational-study-of-24-cases
#9
Ana Rostaher, Natalie Hofer-Inteeworn, Claudia Kümmerle-Fraune, Nina Maria Fischer, Claude Favrot
BACKGROUND: Urticaria and anaphylaxis are frequently encountered in veterinary practice, but little is known about the causes and relative frequencies of these reactions. HYPOTHESIS/OBJECTIVES: This study was designed to improve current knowledge on the triggers, risk factors and clinico-pathological features of urticaria. ANIMALS: Twenty four dogs with signs of urticaria with or without anaphylaxis. METHODS: The study included dogs with cutaneous immediate-type hypersensitivity reactions...
July 18, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27250730/breastfeeding-attitude-and-volume-optimization-bravo-trial-study-protocol-for-a-randomized-controlled-trial
#10
Ary I Savitri, Nikmah S Idris, Wahyuni Indawati, Siti Rizny F Saldi, Dwirani Amelia, Mohammad Baharuddin, Sudigdo Sastroasmoro, Diederick E Grobbee, Cuno S P M Uiterwaal
BACKGROUND: A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial is designed to study the effect of breastfeeding on early signs of later chronic diseases, particularly cardiovascular, respiratory, and metabolic risks later in life. In addition, the effectiveness of breastfeeding empowerment in promoting breastfeeding will also be evaluated...
June 2, 2016: Trials
https://www.readbyqxmd.com/read/27241868/intravascular-ultrasound-guided-mesenteric-stenting-in-patients-with-advanced-chronic-kidney-disease
#11
Keisuke Fukuda, Akihiro Higashimori, Yoshiaki Yokoi
Endovascular treatment of chronic mesenteric ischemia in patients with impaired renal function or allergy to contrast media is a challenging procedure because angiography requires iodinated contrast media for accurate diagnosis and interventional procedures. Superior mesenteric artery stenting without contrast angiography is described in an 81-year-old woman with cardiovascular disease and chronic kidney disease (CKD) stage 5. Balloon angioplasty and stent placement were performed successfully using intravascular ultrasound, pressure wire, surface ultrasound, and fluoroscopy...
August 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27223684/using-health-information-technology-to-foster-engagement-patients-experiences-with-an-active-patient-health-record
#12
John J Rief, Megan E Hamm, Susan L Zickmund, Cara Nikolajski, Dan Lesky, Rachel Hess, Gary S Fischer, Melissa Weimer, Sunday Clark, Caroline Zieth, Mark S Roberts
Personal health records (PHRs) typically employ "passive" communication strategies, such as non-personalized medical text, rather than direct patient engagement in care. Currently there is a call for more active PHRs that directly engage patients in an effort to improve their health by offering elements such as personalized medical information, health coaches, and secure messaging with primary care providers. As part of a randomized clinical trial comparing "passive" with "active" PHRs, we explore patients' experiences with using an "active" PHR known as HealthTrak...
May 25, 2016: Health Communication
https://www.readbyqxmd.com/read/27130856/a-work-group-report-on-ultrafine-particles-american-academy-of-allergy-asthma-immunology-why-ambient-ultrafine-and-engineered-nanoparticles-should-receive-special-attention-for-possible-adverse-health-outcomes-in-human-subjects
#13
Ning Li, Steve Georas, Neil Alexis, Patricia Fritz, Tian Xia, Marc A Williams, Elliott Horner, Andre Nel
Ultrafine particles (UFPs) are airborne particulates of less than 100 nm in aerodynamic diameter. Examples of UFPs are diesel exhaust particles, products of cooking, heating, and wood burning in indoor environments, and, more recently, products generated through the use of nanotechnology. Studies have shown that ambient UFPs have detrimental effects on both the cardiovascular and respiratory systems, including a higher incidence of atherosclerosis and exacerbation rate of asthma. UFPs have been found to alter in vitro and in vivo responses of the immune system to allergens and can also play a role in allergen sensitization...
August 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27088787/-desaturases-of-fatty-acids-fads-and-their-physiological-and-clinical-implication
#14
Aleš Žák, Adolf Slabý, Eva Tvrzická, Marie Jáchymová, Jaroslav Macášek, Marek Vecka, Miroslav Zeman, Barbora Staňková
States associated with insulin resistance, as overweight/obesity, type 2 diabetes mellitus (DM2), cardiovascular diseases (CVD), some cancers and neuropsychiatric diseases are characterized with a decrease of long-chain polyunsaturated fatty acids (LC-PUFA) levels. Amounts of LC-PUFA depend on the exogenous intake of their precursors [linoleic (LA) and α-linolenic acid (ALA)] and by rate of their metabolism, which is influenced by activities of enzymes, such as Δ6-desaturase (D6D, FADS2), D5D, FADS1, elongases (Elovl2, -5, 6)...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27049072/is-vitamin-e-an-anti-allergic-compound
#15
A L Caraffa, G Varvara, E Spinas, S K Kritas, G Lessiani, G Ronconi, A Saggini, P Antinolfi, I Frydas, M C De Tommaso Morrison, P Conti
Vitamin E is found in eight forms in nature which include four tocopherols (alpha, beta, gamma and delta) and four tocotrianols (alpha, beta, gamma and delta). The classic effect of vitamin E is to reduce and prevent oxygen damage to the tissue and is useful for the treatment of pain, inflammation and allergic reactions. In addition to antioxidant activity, vitamin E also has a number of different and related functions. It protects against cancer, improves immune response, lowers the incidence of infectious diseases, cardiovascular diseases and is protective in allergy and asthma risk, and other disorders...
January 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/26954764/paricalcitol-attenuates-lipopolysaccharide-induced-myocardial-inflammation-by-regulating-the-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Ae Sin Lee, Yu Jin Jung, Tùng Nguyễn Thanh, Sik Lee, Won Kim, Kyung Pyo Kang, Sung Kwang Park
Vitamin D deficiency is associated with an increased risk of cardiovascular disease, diabetes, colon and breast cancer, infectious diseases and allergies. Vascular alterations are an important pathophysiological mechanism of sepsis. Experimental data suggest that paricalcitol, a vitamin D2 analogue, exerts beneficial effects on renal inflammation and fibrosis. In the present study, we aimed to investigate the effects of paricalcitol on lipopolysaccharide (LPS)-induced myocardial inflammation and to elucidate the underlying mechanisms...
April 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/26872716/-general-concepts-of-epigenetics-projections-in-paediatrics
#17
Bernardo J Krause, José A Castro-Rodríguez, Ricardo Uauy, Paola Casanello
Current evidence supports the notion that alterations in intrauterine growth and during the first years of life have a substantial effect on the risk for the development of chronic disease, which in some cases is even higher than those due to genetic factors. The persistence and reproducibility of the phenotypes associated with altered early development suggest the participation of mechanisms that would record environmental cues, generating a cellular reprogramming (i.e., epigenetic mechanisms). This review is an introduction to a series of five articles focused on the participation of epigenetic mechanisms in the development of highly prevalent chronic diseases (i...
January 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/26866410/cardiovascular-collapse-associated-with-irreversible-cardiomyopathy-chronic-renal-failure-and-hypertension-during-routine-dental-care
#18
Sean Thoms, Matthew Cooke, James Crawford
Patients with multiple comorbid conditions visit the dental office every day, and although rare, complications from their conditions may occur during treatment. A case is presented of a 65-year-old African American woman with a history of severe cardiovascular disease, renal disease, and a reported local anesthetic allergy who experienced complete cardiovascular collapse during routine dental treatment from which she was successfully resuscitated. Treating clinicians should recognize the emerging symptoms and be proficient with a basic and advanced cardiac life support protocol to care for their patients safely and effectively until they can be transported to more advanced care facilities...
2016: Anesthesia Progress
https://www.readbyqxmd.com/read/26823080/impacts-of-extreme-heat-on-emergency-medical-service-calls-in-king-county-washington-2007-2012-relative-risk-and-time-series-analyses-of-basic-and-advanced-life-support
#19
Miriam M Calkins, Tania Busch Isaksen, Benjamin A Stubbs, Michael G Yost, Richard A Fenske
BACKGROUND: Exposure to excessive heat kills more people than any other weather-related phenomenon, aggravates chronic diseases, and causes direct heat illness. Strong associations between extreme heat and health have been identified through increased mortality and hospitalizations and there is growing evidence demonstrating increased emergency department visits and demand for emergency medical services (EMS). The purpose of this study is to build on an existing regional assessment of mortality and hospitalizations by analyzing EMS demand associated with extreme heat, using calls as a health metric, in King County, Washington (WA), for a 6-year period...
2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/26802473/atypical-manifestations-of-epstein-barr-virus-in-children-a-diagnostic-challenge
#20
Vasileios Bolis, Christos Karadedos, Ioannis Chiotis, Nikolaos Chaliasos, Sophia Tsabouri
OBJECTIVE: Clarify the frequency and the pathophysiological mechanisms of the rare manifestations of Epstein-Barr virus infection. SOURCES: Original research studies published in English between 1985 and 2015 were selected through a computer-assisted literature search (PubMed and Scopus). Computer searches used combinations of key words relating to "EBV infections" and "atypical manifestation." SUMMARY OF THE FINDINGS: Epstein-Barr virus is a herpes virus responsible for a lifelong latent infection in almost every adult...
March 2016: Jornal de Pediatria
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