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https://www.readbyqxmd.com/read/29036982/-research-advances-on-the-relationship-between-nitrate-nitrite-no-pathway-and-heart-failure-with-preserved-ejection-fraction
#1
Y Meng, Z Y Zhang
No abstract text is available yet for this article.
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036974/-the-impact-of-hydrogen-sulfide-on-the-heme-oxygenase-1-carbon-monoxide-system-in-coxsackie-virus-b3-induced-myocarditis-in-mice
#2
S Y Zhang, T T Wu, Y Ren, T H Xia, R Z Wu
Objective: To explore the impact of hydrogen sulfide (H(2)S) on the heme oxygenase-1/carbon monoxide pathway in Coxsackie virus B3 (CVB3)-induced murine myocarditis (VMC) model. Method: A total of 70 inbred male Balb/c mouse (4-6 weeks old) were randomized into the following four groups: Normal, VMC, PAG and NaHS (n=10 for Normal, n=20 for VMC, PAG and NaHS groups). Mice in Normal group were non-infected mice treated with intraperitoneal injection of sterile phosphate-buffered saline daily for 10 days.Mice in VMC group received intraperitoneal CVB3 injection (0...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036909/diabetes-induced-dysfunction-of-mitochondria-and-stem-cells-in-skeletal-muscle-and-the-nervous-system
#3
REVIEW
Shin Fujimaki, Tomoko Kuwabara
Diabetes mellitus is one of the most common metabolic diseases spread all over the world, which results in hyperglycemia caused by the breakdown of insulin secretion or insulin action or both. Diabetes has been reported to disrupt the functions and dynamics of mitochondria, which play a fundamental role in regulating metabolic pathways and are crucial to maintain appropriate energy balance. Similar to mitochondria, the functions and the abilities of stem cells are attenuated under diabetic condition in several tissues...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#4
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036835/therapeutic-role-of-long-non-coding-rna-tcons_00019174-in-depressive-disorders-is-dependent-on-wnt-%C3%AE-catenin-signaling-pathway
#5
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu
Chronic stress is one of the major causes that lead to major depressive disorder (MDD), which is a prevalent mood disorder worldwide. Lots of MDD patients could not benefit from available medication due to the complex etiology of MDD. Recently, long non-coding RNAs (lncRNAs), molecular switches of downstream genes expression, have been reported to be involved in the pathogenesis of MDD. LncRNA TCONS_00019174 has been implicated in MDD risk and antidepressant effects, However, the effect of lncRNA TCONS_00019174 on antidepressant responses has not been investigated...
October 13, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29036827/validation-by-magnetic-resonance-imaging-of-the-diagnostic-potential-of-a-heptapeptide-functionalized-imaging-probe-targeted-to-amyloid-%C3%AE-and-able-to-cross-the-blood-brain-barrier
#6
Séverine André, Emilie Ansciaux, Elamine Saidi, Lionel Larbanoix, Dimitri Stanicki, Denis Nonclercq, Luce Vander Elst, Sophie Laurent, Robert N Muller, Carmen Burtea
The diagnosis of Alzheimer's disease (AD) is a critical step in the management of patients. We have developed a non-invasive diagnosis tool based on magnetic resonance molecular imaging (MRMI) of amyloid-β peptide using ultra-small particles of iron oxide (USPIO) functionalized with a disulfide constrained cyclic heptapeptide (PHO) identified by phage display (USPIO-PHO). After previously demonstrating the optimal pharmacologic properties of USPIO-PHO and its capacity to cross the blood-brain barrier (BBB), the ability of USPIO-PHO to target amyloid plaques (AP) by MRMI has been validated in the present work on AD transgenic mice...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036812/altered-gut-microbiota-in-a-mouse-model-of-alzheimer-s-disease
#7
Ling Zhang, Ying Wang, Xia Xiayu, Changhua Shi, Wei Chen, Nan Song, Xinjing Fu, Rui Zhou, Yan-Feng Xu, Lan Huang, Hua Zhu, Yunlin Han, Chuan Qin
The topic of gut microbiota is currently attracting considerable interest as a potential factor in Alzheimer's disease (AD). However, the extent and time course of alterations in the gut microbiota, and their effects on AD pathology remain uncertain. Herein, we compared the fecal microbiomes and fecal short chain fatty acid composition (SCFAs) between wild-type and AD model mice at different ages under strictly controlled specific pathogen free conditions, and also conducted microscopic investigations of intestinal structures...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036751/-diagnosis-and-management-of-vestibular-schwannomas-an-interdisciplinary-challenge
#8
Steffen Rosahl, Christopher Bohr, Michael Lell, Klaus Hamm, Heinrich Iro
Vestibular schwannomas expand slowly in the internal auditory canal, in the cerebellopontine angle, inside the cochlear and the labyrinth. Larger tumors can displace and compress the brainstem. With an annual incidence of 1:100 000 vestibular schwannoma represent 6-7% of all intracranial tumors. In the cerebellopontine angle they are by far the most neoplasm with 90% of all lesions located in this region. Magnetic resonance imaging (MRI), audiometry, and vestibular diagnostics are the mainstays of the clinical workup for patients harboring tumors...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29036705/chalcogenozidovudine-derivatives-with-antitumor-activity-comparative-toxicities-in-cultured-human-mononuclear-cells
#9
Assis Ecker, Pauline Christ Ledur, Rafael S da Silva, Daniela Bitencourt Rosa Leal, Oscar E D Rodrigues, Daniel Ardisson-Araújo, Emily Pansera Waczuk, João Batista Teixeira da Rocha, Nilda Vargas Barbosa
Considering a novel series of zidovudine (AZT) derivatives encompassing selenoaryl moieties promising candidates as therapeutics, we examined the toxicities elicited by AZT and derivatives 5'-(4-Chlorophenylseleno)zidovudine (SZ1); 5'-(Phenylseleno)zidovudine (SZ2); and 5'-(4-Methylphenylseleno)zidovudine (SZ3) in healthy cells and in mice. Resting and stimulated cultured human peripheral blood mononuclear cells (PBMCs) were treated with the compounds at concentrations ranging from 10 to 200 µM for 24 and/or 72 h...
July 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29036670/catalytic-and-structural-properties-of-pheophytinase-the-phytol-esterase-involved-in-chlorophyll-breakdown
#10
Luzia Guyer, Kathrin Salinger, Undine Krügel, Stefan Hörtensteiner
During leaf senescence and fruit ripening, chlorophyll is degraded in a multistep pathway into linear tetrapyrroles called phyllobilins. A key feature of chlorophyll breakdown is the removal of the hydrophobic phytol chain that renders phyllobilins water soluble, an important prerequisite for their ultimate storage in the vacuole of senescent cells. Chlorophyllases had been considered for more than a century to catalyze dephytylation in vivo; however, this was recently refuted. Instead, pheophytinase was discovered as a genuine in vivo phytol hydrolase...
September 23, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036669/comparative-genome-and-transcriptome-analyses-reveal-adaptations-to-opportunistic-infections-in-woody-plant-degrading-pathogens-of-botryosphaeriaceae
#11
Ji Ye Yan, Wen Sheng Zhao, Zhen Chen, Qi Kai Xing, Wei Zhang, K W Thilini Chethana, Min Feng Xue, Jian Ping Xu, Alan J L Phillips, Yong Wang, Jian Hua Liu, Mei Liu, Ying Zhou, Ruvishika S Jayawardena, Ishara S Manawasinghe, Jin Bao Huang, Guang Hang Qiao, Chun Yuan Fu, Fei Fei Guo, Asha J Dissanayake, You Liang Peng, Kevin D Hyde, Xing Hong Li
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about factors that trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae and five other genomes of Botryosphaeriaceae pathogens. Botryosphaeriaceous genomes showed an expansion of gene families associated with cell wall degradation, nutrient uptake, secondary metabolism and membrane transport, which contribute to adaptations for wood degradation...
October 3, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29036667/disnor-a-disease-network-open-resource
#12
Prisca Lo Surdo, Alberto Calderone, Marta Iannuccelli, Luana Licata, Daniele Peluso, Luisa Castagnoli, Gianni Cesareni, Livia Perfetto
DISNOR is a new resource that aims at exploiting the explosion of data on the identification of disease-associated genes to assemble inferred disease pathways. This may help dissecting the signaling events whose disruption causes the pathological phenotypes and may contribute to build a platform for precision medicine. To this end we combine the gene-disease association (GDA) data annotated in the DisGeNET resource with a new curation effort aimed at populating the SIGNOR database with causal interactions related to disease genes with the highest possible coverage...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036633/rna-sequencing-of-brassica-napus-reveals-cellular-redox-control-of-sclerotinia-infection
#13
Ian J Girard, Chaobo Tong, Michael G Becker, Xingyu Mao, Junyan Huang, Teresa de Kievit, W G Dilantha Fernando, Shengyi Liu, Mark F Belmonte
Brassica napus is one of the world's most valuable oilseeds and is under constant pressure by the necrotrophic fungal pathogen, Sclerotinia sclerotiorum, the causal agent of white stem rot. Despite our growing understanding of host pathogen interactions at the molecular level, we have yet to fully understand the biological processes and underlying gene regulatory networks responsible for determining disease outcomes. Using global RNA sequencing, we profiled gene activity at the first point of infection on the leaf surface 24 hours after pathogen exposure in susceptible (B...
September 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036627/using-uncertainty-to-link-and-rank-evidence-from-biomedical-literature-for-model-curation
#14
Chrysoula Zerva, Riza Batista-Navarro, Philip Day, Sophia Ananiadou
Motivation: In recent years, there has been great progress in the field of automated curation of biomedical networks and models, aided by text mining methods that provide evidence from literature. Such methods must not only extract snippets of text that relate to model interactions, but also be able to contextualize the evidence and provide additional confidence scores for the interaction in question. Although various approaches calculating confidence scores have focused primarily on the quality of the extracted information, there has been little work on exploring the textual uncertainty conveyed by the author...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036578/the-roles-of-membranes-and-associated-cytoskeleton-in-plant-virus-replication-and-cell-to-cell-movement
#15
Nicolas Pitzalis, Manfred Heinlein, Gian Pietro Di Sansebastiano
The infection of plants by viruses depends on cellular mechanisms that support the replication of the viral genomes, and the cell-to-cell and systemic movement of the virus via plasmodesmata (PD) and the connected phloem. While the propagation of some viruses requires the conventional endoplasmic reticulum (ER)-Golgi pathway, others replicate and spread between cells in association with the ER and are independent of this pathway. Using selected viruses as examples, this review re-examines the involvement of membranes and the cytoskeleton during virus infection and proposes potential roles of class VIII myosins and membrane-tethering proteins in controlling viral functions at specific ER subdomains, such as cortical microtubule-associated ER sites, ER-plasma membrane contact sites, and PD...
October 3, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036515/the-jasmonate-zim-domain-gene-family-mediates-ja-signaling-and-stress-response-in-cotton
#16
Heng Sun, Lin Chen, Jianying Li, Meiling Hu, Abid Ullah, Xin He, Xiyan Yang, Xianlong Zhang
JASMONATE ZIM-domain (JAZ) family proteins are involved in regulating diverse biological processes in plants. However, their functions have not been well characterized in cotton (Gossypium spp.). In the present study, 13, 15, 25, and 30 JAZ genes were identified in Gossypium arboretum, Gossypium raimondii, Gossypium barbadense and Gossypium hirsutum respectively, based on gene homology. Selection and variation analyses showed that the SNP density of GhJAZ genes in wild species was much higher than that in domesticated species...
October 3, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036449/resveratrol-attenuates-bone-cancer-pain-through-regulating-the-expression-levels-of-asic3-and-activating-cell-autophagy
#17
Haili Zhu, Jieqiong Ding, J Wu, Tingting Liu, Jing Liang, Qiong Tang, Ming Jiao
Bone cancer pain (BCP) is one of the most common pains in patients with malignant cancers. The mechanism underlying BCP is largely unknown. Our previous studies and the increasing evidence both have shown that acid-sensing ion channels 3 (ASIC3) is an important protein in the pathological pain state in some pain models. We hypothesized that the expression change of ASIC3 might be one of the factors related to BCP. In this study, we established the BCP model through intrathecally injecting rat mammary gland carcinoma cells (MRMT-1) into the left tibia of Sprague-Dawley female rats, and found that the BCP rats showed bone destruction, increased mechanical pain sensitivities and up-regulated ASIC3 protein expression levels in L4-L6 dorsal root ganglion...
October 3, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036441/the-role-of-the-er-stress-response-protein-perk-in-rhodopsin-retinitis-pigmentosa
#18
Dimitra Athanasiou, Monica Aguila, James Bellingham, Naheed Kanuga, Peter Adamson, Michael E Cheetham
Mutations in rhodopsin, the light sensitive protein of rod cells, are the most common cause of dominant retinitis pigmentosa (RP), a type of inherited blindness caused by the dysfunction and death of photoreceptor cells. The P23H mutation, the most frequent single cause of RP in the USA, causes rhodopsin misfolding and induction of the unfolded protein response (UPR), an adaptive ER stress response and signalling network that aims to enhance the folding and degradation of misfolded proteins to restore proteostasis...
September 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036356/lipopolysaccharide-promotes-angiogenesis-in-mice-model-of-hcc-by-stimulating-hepatic-stellate-cell-activation-via-tlr4-pathway
#19
Y Lu, Jianliang Xu, Shuxian Chen, Zheng Zhou, Nan Lin
Angiogenesis plays a key role in the progression of hepatocellular carcinoma (HCC). This study aimed to investigate whether lipopolysaccharide (LPS) could promote HCC angiogenesis and the role of hepatic stellate cell (HSC) in this process. In vivo orthotopic HCC model and the effect of LPS on HSC in vitro were studied. Our results demonstrated that LPS-induced HSC activation during the promotion of HCC growth and angiogenesis in mice. The LPS-TLR4 (Toll-like receptor 4) pathway in HSC is responsible for HCC angiogenesis...
September 23, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036339/contribution-of-major-flm-isoforms-to-temperature-dependent-flowering-in-arabidopsis-thaliana
#20
Giovanna Capovilla, Efthymia Symeonidi, Rui Wu, Markus Schmid
FLOWERING LOCUS M (FLM), a component of the thermosensory flowering time pathway in Arabidopsis thaliana, is regulated by temperature-dependent alternative splicing (AS). The main splicing variant, FLM-β, is a well-documented floral repressor that is down-regulated in response to increasing ambient growth temperature. Two hypotheses have been formulated to explain how flowering time is modulated by AS of FLM. In the first model a second splice variant, FLM-δ, acts as a dominant negative isoform that competes with FLM-β at elevated ambient temperatures, thereby indirectly promoting flowering...
September 25, 2017: Journal of Experimental Botany
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