keyword
MENU ▼
Read by QxMD icon Read
search

On and Off Pathways

keyword
https://www.readbyqxmd.com/read/28324780/the-longitudinal-relationship-between-control-over-working-hours-and-depressive-symptoms-results-from-slosh-a-population-based-cohort-study
#1
Sophie C Albrecht, Göran Kecklund, Kristiina Rajaleid, Constanze Leineweber
BACKGROUND: Psychosocial work factors can affect depressive moods, but research is inconclusive if flexibility to self-determine working hours (work-time control, WTC) is associated with depressive symptoms over time. We investigated if either sub-dimension of WTC, control over daily hours and control over time off, was related to depressive symptoms over time and examined causal, reversed-causal, and reciprocal pathways. METHODS: The study was based on four waves of the Swedish Longitudinal Occupational Survey of Health which is a follow-up of representative samples of the Swedish working population...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28324699/low-vigorous-physical-activity-is-associated-with-increased-adrenocortical-reactivity-to-psychosocial-stress-in-students-with-high-stress-perceptions
#2
Markus Gerber, Sebastian Ludyga, Manuel Mücke, Flora Colledge, Serge Brand, Uwe Pühse
OBJECTIVES: The pathways by which physical activity impacts on participants' health are still not fully understood. The purpose of the present study was to go beyond existing research by combining methods from survey-based and experimental stress research, and by examining whether the potential of vigorous physical activity (VPA) to attenuate physiological and psychological stress responses is moderated by participants' subjective stress perception. METHODS: The sample consisted of 42 undergraduate students (M=21...
March 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28314838/a-phase-i-study-of-abiraterone-acetate-combined-with-bez235-a-dual-pi3k-mtor-inhibitor-in-metastatic-castration-resistant-prostate-cancer
#3
Xiao X Wei, Andrew C Hsieh, Won Kim, Terence Friedlander, Amy M Lin, Mirela Louttit, Charles J Ryan
LESSONS LEARNED: The combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate cancer, agents that more selectively target PI3K-AKT-mTOR signaling may have a more favorable therapeutic index and should continue to be explored. BACKGROUND: Androgen receptor (AR) and phosphatidylinositol-3 kinase (PI3K) signaling are two commonly perturbed pathways in prostate cancer...
March 17, 2017: Oncologist
https://www.readbyqxmd.com/read/28303528/human-mass-balance-study-and-metabolite-profiling-of-14-c-niraparib-a-novel-poly-adp-ribose-polymerase-parp-1-and-parp-2-inhibitor-in-patients-with-advanced-cancer
#4
Lotte van Andel, Z Zhang, S Lu, V Kansra, S Agarwal, L Hughes, M M Tibben, A Gebretensae, L Lucas, M J X Hillebrand, H Rosing, J H M Schellens, J H Beijnen
Niraparib is an investigational oral, once daily, selective poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor. In the pivotal Phase 3 NOVA/ENGOT/OV16 study, niraparib met its primary endpoint of improving progression-free survival (PFS) for adult patients with recurrent, platinum sensitive, ovarian, fallopian tube, or primary peritoneal cancer in complete or partial response to platinum-based chemotherapy. Significant improvements in PFS were seen in all patient cohorts regardless of biomarker status...
March 16, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28295344/connectomics-of-synaptic-microcircuits-lessons-from-the-outer-retina
#5
Luke Edward Rogerson, Christian Behrens, Thomas Euler, Philipp Berens, Timm Schubert
Photoreceptors form a sophisticated synaptic complex with bipolar and horizontal cells, transmitting the signals generated by the phototransduction cascade to downstream retinal circuitry. The cone photoreceptor synapse shows several characteristic anatomical connectivity motifs that shape signal transfer: Typically, ON-cone bipolar cells receive photoreceptor input through invaginating synapses; OFF-cone bipolar cells form basal synapses with photoreceptors. Both ON- and OFF-cone bipolar cells are believed to sample from all cone photoreceptors within their dendritic span...
March 10, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28288819/multifaceted-anticancer-activity-of-bh3-mimetics-current-evidence-and-future-prospects
#6
REVIEW
Małgorzata Opydo-Chanek, Oscar Gonzalo, Isabel Marzo
BH3 mimetics are a novel class of anticancer agents designed to specifically target pro-survival proteins of the Bcl-2 family. Like endogenous BH3-only proteins, BH3 mimetics competitively bind to surface hydrophobic grooves of pro-survival Bcl-2 family members, counteracting their protective effects and thus facilitating apoptosis in cancer cells. Among the small-molecule BH3 mimetics identified, ABT-737 and its analogs, obatoclax as well as gossypol derivatives are the best characterized. The anticancer potential of these compounds applied as a single agent or in combination with chemotherapeutic drugs is currently being evaluated in preclinical studies and in clinical trials...
March 10, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28284760/a-peer-review-process-as-part-of-the-implementation-of-clinical-pathways-in-radiation-oncology-does-it-improve-compliance
#7
Brian J Gebhardt, Dwight E Heron, Sushil Beriwal
PURPOSE: Clinical pathways are patient management plans that standardize evidence-based practices to ensure high-quality and cost-effective medical care. Implementation of a pathway is a collaborative process in our network, requiring the active involvement of physicians. This approach promotes acceptance of pathway recommendations, although a peer review process is necessary to ensure compliance and to capture and approve off-pathway selections. We investigated the peer review process and factors associated with time to completion of peer review...
January 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28273416/%C3%AE-helix-mimetics-as-modulators-of-a%C3%AE-self-assembly
#8
Sunil Kumar, Andrew D Hamilton
A key molecular species in Alzheimer's disease (AD) is the Aβ42 alloform of Aβ peptide, which is dominant in the amyloid plaques deposited in the brains of AD patients. Recent studies have decisively demonstrated that the prefibrillar soluble oligomers are the neurotoxic culprits and are associated with the pathology of AD. Nascent Aβ42 is predominantly disordered but samples α-helical conformations covering residues 15-24 and 29-35 in the presence of micelles and structure-inducing solvents. In this report, a focused library of oligopyridylamide based α-helical mimetics was designed to target the central α-helix subdomain of Aβ (Aβ13-26)...
March 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28267640/the-nrf2-are-signaling-pathway-an-update-on-its-regulation-and-possible-role-in-cancer-prevention-and-treatment
#9
REVIEW
Violetta Krajka-Kuźniak, Jarosław Paluszczak, Wanda Baer-Dubowska
Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The activation of Nrf2 signaling induces ARE-dependent expression of detoxifying and antioxidant defense proteins. Nrf2-ARE signaling has become an attractive target for cancer chemoprevention. On the other hand, constitutive over-activation of Nrf2 in cancer cells has been implicated in cancer progression as well as in resistance to cancer chemotherapeutics. Two basic Nrf2 activation pathways were described. The canonical pathway is the primary mechanism of Nrf2 activation and is based on dissociation of Nrf2 from its inactive complex with the repressor protein Keap1 and the subsequent translocation of Nrf2 into the nucleus...
December 23, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28264934/structure-activity-relationship-of-thapsigargin-inhibition-on-the-purified-golgi-secretory-pathway-ca2-mn2-transport-atpase-spca1a
#10
Jialin Chen, Joren De Raeymaecker, Jannik Brøndsted Hovgaard, Susanne Smaardijk, Ilse Vandecaetsbeek, Frank Wuytack, Jesper Vuust Møller, Jan Eggermont, Marc De Maeyer, Søren Brøgger Christensen, Peter Vangheluwe
The Golgi/secretory pathway Ca2+/Mn2+ transport ATPase (SPCA1a) is implicated in breast cancer and Hailey-Hailey disease. Here, we purified recombinant human SPCA1a from Saccharomyces cerevisiae and measured Ca2+ dependent ATPase activity following reconstitution in proteoliposomes. The purified SPCA1a displays a higher apparent Ca2+ affinity and lower maximal turnover rate than the purified sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1a). The lipids cholesteryl hemisuccinate, linole-/oleamide and phosphatidyl ethanolamine inhibit, whereas phosphatidic acid and sphingomyelin enhance SPCA1a activity...
March 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28261079/does-motor-simulation-theory-explain-the-cognitive-mechanisms-underlying-motor-imagery-a-critical-review
#11
REVIEW
Helen O'Shea, Aidan Moran
Motor simulation theory (MST; Jeannerod, 2001) purports to explain how various action-related cognitive states relate to actual motor execution. Specifically, it proposes that motor imagery (MI; imagining an action without executing the movements involved) shares certain mental representations and mechanisms with action execution, and hence, activates similar neural pathways to those elicited during the latter process. Furthermore, MST postulates that MI works by rehearsing neural motor systems off-line via a hypothetical simulation process...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28256574/tissue-specific-tumorigenesis-context-matters
#12
REVIEW
Günter Schneider, Marc Schmidt-Supprian, Roland Rad, Dieter Saur
How can we treat cancer more effectively? Traditionally, tumours from the same anatomical site are treated as one tumour entity. This concept has been challenged by recent breakthroughs in cancer genomics and translational research that have enabled molecular tumour profiling. The identification and validation of cancer drivers that are shared between different tumour types, spurred the new paradigm to target driver pathways across anatomical sites by off-label drug use, or within so-called basket or umbrella trials which are designed to test whether molecular alterations in one tumour entity can be extrapolated to all others...
March 3, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28253405/contributions-of-second-and-third-order-retinal-neurons-to-cone-electroretinograms-after-loss-of-rod-function-in-rhodopsin-p347l-transgenic-rabbits
#13
Taro Kominami, Shinji Ueno, Satoshi Okado, Ayami Nakanishi, Mineo Kondo, Hiroko Terasaki
Purpose: To determine the contribution of second- and third-order retinal neurons to the photopic electroretinograms (ERGs) after the degeneration of the rods in rhodopsin P347L transgenic rabbits (Tg). Methods: Four wild-type (WT) rabbits and four Tg rabbits were studied at 18 months of age. The photopic ERGs elicited at stimulus onset and offset were analyzed. To block different retinal pathways, 2-amino-4-phosphonobutyric acid (APB), 6-cyano-7-nitroquinoxaline-2, 3 (1H,4H)-dione (CNQX), tetrodotoxin (TTX), and N-methyl-DL-aspartic acid (NMDA) were injected intravitreally...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28252478/response-of-braf-inhibitor-associated-squamous-cell-lung-carcinoma-to-drug-withdrawal
#14
Jonathan T Blackmon, Ratika Dhawan, Nina L Terry, Robert M Conry
Vemurafenib and dabrafenib, two Food and Drug Administration-approved selective BRAF kinase inhibitors (BRAFi), have revolutionized the targeted therapy of cutaneous melanoma. Off-target effects of these drugs paradoxically activate the MAP kinase pathway in BRAF wild-type cells, leading to secondary malignancies. Although cutaneous squamous cell carcinomas are by far the most frequent, emergence of potentially life-threatening secondary tumors from other sites following prolonged therapy is a growing concern...
April 2017: Melanoma Research
https://www.readbyqxmd.com/read/28248982/a-dual-pathways-transfer-model-to-account-for-changes-in-the-radioactive-caesium-level-in-demersal-and-pelagic-fish-after-the-fukushima-da%C3%A3-ichi-nuclear-power-plant-accident
#15
Bruno Fiévet, Pascal Bailly-du-Bois, Philippe Laguionie, Mehdi Morillon, Mireille Arnaud, Pascal Cunin
The Fukushima Daï-ichi nuclear power plant (FDNPP) accident resulted in radioactive Cs being discharged into the local marine environment. While Cs bioaccumulates in biota and slowly depurates, the Cs concentrated in biota constitutes a source of Cs for animals feeding on each other. The marine biota therefore serves as a pool that recycles Cs, and this recycling process delays depuration in the fish feeding on this biota pool. Because the continental shelf is squeezed between the coast and very deep sea, the demersal marine species are confined to a narrow strip along the coast, close to the source of the radioactive input...
2017: PloS One
https://www.readbyqxmd.com/read/28248930/genome-wide-sirna-screen-of-genes-regulating-the-lps-induced-tnf-%C3%AE-response-in-human-macrophages
#16
Jing Sun, Samuel Katz, Bhaskar Dutta, Ze Wang, Iain D C Fraser
The mammalian innate immune system senses many bacterial stimuli through the toll-like receptor (TLR) family. Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis. Here we describe a genome-wide siRNA screen to identify genes regulating the human macrophage TNF-α response to LPS. We include a secondary validation screen conducted with six independent siRNAs per gene to facilitate removal of off-target screen hits...
March 1, 2017: Scientific Data
https://www.readbyqxmd.com/read/28242236/centenarians-as-extreme-phenotypes-an-ecological-perspective-to-get-insight-into-the-relationship-between-the-genetics-of-longevity-and-age-associated-diseases
#17
REVIEW
Cristina Giuliani, Chiara Pirazzini, Massimo Delledonne, Luciano Xumerle, Patrick Descombes, Julien Marquis, Giacomo Mengozzi, Daniela Monti, Dina Bellizzi, Giuseppe Passarino, Donata Luiselli, Claudio Franceschi, Paolo Garagnani
In this review we address the genetic continuum between aging and age-related diseases, with particular attention to the ecological perspective. We describe the connections between genes that promote longevity and genes associated to age-related diseases considering trade-off mechanisms in which the same genetic variants could have different effect according to the tissue considered and could be involved in several biological pathways. Then we describe mechanisms of antagonistic pleiotropy, focusing on the complex interplay between genetic variants and environmental changes (internal or external)...
February 24, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28240549/small-molecule-inhibition-of-microrna-210-reprograms-an-oncogenic-hypoxic-circuit
#18
Matthew G Costales, Christopher L Haga, Sai Pradeep Velagapudi, Jessica L Childs-Disney, Donald G Phinney, Matthew D Disney
A hypoxic state is critical to the metastatic and invasive characteristics of cancer. Numerous pathways play critical roles in cancer maintenance, many of which include noncoding RNAs such as microRNA (miR)-210 that regulates hypoxia inducible factors (HIFs). Herein, we describe the identification of a small molecule named Targapremir-210 that binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA, derepresses glycerol-3-phosphate dehydrogenase 1-like enzyme (GPD1L), a hypoxia-associated protein negatively regulated by miR-210, decreases HIF-1α, and triggers apoptosis of triple negative breast cancer cells only under hypoxic conditions...
February 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28236279/oas-gene-family-expression-is-associated-with-hiv-related-neurocognitive-disorders
#19
C Sanfilippo, M R Pinzone, D Cambria, A Longo, M Palumbo, R Di Marco, F Condorelli, G Nunnari, L Malaguarnera, M Di Rosa
HIV-associated neurocognitive disorders are common in HIV-infected individuals, even in the combination antiretroviral therapy (c-ART) era. Several mechanisms are involved in neuronal damage, including chronic inflammation immune activation. Mammalian 2'-5'-oligoadenylate synthetase (OAS) genes are produced in response to interferon (IFN), mainly by monocytes, and exert their antiviral functions by activation of RNase L that degrades viral and cellular RNAs. In this study, we aimed at exploring OAS gene family RNA expression in simian immunodeficiency virus encephalitis (SIVE), in HIV-associated neurocognitive disorders (HAND), and in HIV-associate dementia (HAD)...
February 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28230385/auditory-cue-absence-as-a-conditioned-stimulus-for-delay-eyeblink-conditioning
#20
Matthew M Campolattaro, Sean W Savage, Olga Lipatova
The present experiment was designed to determine if the absence of an auditory cue (i.e., a "tone-off" cue) would be an effective conditioned stimulus (CS) for delay eyeblink conditioning and to test if the medial geniculate nucleus (MGN) is part of the sensory pathway for tone-off conditioning. Rats were given paired or unpaired delay eyeblink conditioning to examine if responding to a tone-off CS was due to an associative process. An inactivation technique was performed on a separate group of rats to determine if the MGN is needed to express tone-off conditioning...
April 2017: Behavioral Neuroscience
keyword
keyword
26086
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"