keyword
MENU ▼
Read by QxMD icon Read
search

Off pathway

keyword
https://www.readbyqxmd.com/read/28525892/rasal1-is-a-potent-regulator-of-hepatic-stellate-cell-activity-and-liver-fibrosis
#1
Akemi Takata, Motoyuki Otsuka, Takahiro Kishikawa, Mari Yamagami, Rei Ishibashi, Kazuma Sekiba, Tatsunori Suzuki, Motoko Ohno, Yui Yamashita, Takaya Abe, Ryota Masuzaki, Tsuneo Ikenoue, Kazuhiko Koike
Liver fibrosis, leading to cirrhosis and liver failure, can occur after chronic liver injury. The transition of hepatic stellate cells (HSCs) from quiescent cells into proliferative and fibrogenic cells is a central event in liver fibrosis. Here, we show that RAS protein activator like-1 (RASAL1), a RAS-GTPase-activating protein, which switches off RAS activity, is significantly decreased during HSC activation, and that HSC activation can be antagonized by forced expression of the RASAL1 protein. We demonstrate that RASAL1 suppresses HSC proliferation by regulating the Ras-MAPK pathway, and that RASAL1 suppresses HSC fibrogenic activity by regulating the PKA-LKB1-AMPK-SRF pathway by interacting with angiotensin II receptor, type 1...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524004/urinary-biomarkers-for-prostate-cancer
#2
Francesca Giunchi, Chiara Ciccarese, Rodolfo Montironi, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Holger Moch, Francesco Massari, Michelangelo Fiorentino
Urine may represent a convenient source of biomarkers for the early detection of prostate cancer (PCa) since contains secreted prostatic products and exfoliated tumor cells. Furthermore urine are easy to collect with non-invasive procedures and they are repeatable. Several urinary biomarkers for PCa have been proposed in the past but only one (PCA3) has been approved for clinical use and even this is not widely utilized in the routine practice. Most of these, particularly the proteins, were abandoned due to lack of confirmation...
May 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28521210/selective-thermal-transformation-of-old-computer-printed-circuit-boards-to-cu-sn-based-alloy
#3
Ali Shokri, Farshid Pahlevani, Ivan Cole, Veena Sahajwalla
This study investigates, verifies and determines the optimal parameters for the selective thermal transformation of problematic electronic waste (e-waste) to produce value-added copper-tin (Cu-Sn) based alloys; thereby demonstrating a novel new pathway for the cost-effective recovery of resources from one of the world's fastest growing and most challenging waste streams. Using outdated computer printed circuit boards (PCBs), a ubiquitous component of e-waste, we investigated transformations across a range of temperatures and time frames...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28515296/hepatitis-c-virus-lipoviroparticles-hcv-lvp-assemble-in-the-endoplasmic-reticulum-er-and-bud-off-from-the-er-to-golgi-in-copii-vesicles
#4
Gulam H Syed, Mohsin Khan, Song Yang, Aleem Siddiqui
Hepatitis C virus (HCV) exists as a lipoprotein-virus hybrid lipoviroparticle (LVP). In vitro studies have demonstrated the importance of apolipoproteins in HCV secretion and infectivity leading to the notion that HCV co-opts the secretion of very-low density lipoprotein (VLDL) for its egress. However, our understanding of the mechanisms involved in virus particle assembly and egress, are still elusive. Biogenesis of VLDL particle occurs in the ER followed by subsequent lipidation in the ER and Golgi. Secretion of mature VLDL particles occurs through the Golgi secretory pathway...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28513971/predictors-and-the-distal-outcome-of-general-internet-use-the-identification-of-children-s-developmental-trajectories
#5
Jeong Jin Yu, Su Jung Park
This study examined the predictors and distal outcome in relation to the frequency of online activities and investigated the presence of prototypical trajectories following different patterns of general Internet use over 5 years. The data set consisted of a nationally representative sample of 2,840 fourth graders (Mage  = 9.86 years) in South Korea at baseline. Analyses revealed rank-order stability in general Internet use with four latent classes: high stable (5.8%), high quadratic (20.3%), moderate stable (32...
May 17, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28513433/distributing-tasks-via-multiple-input-pathways-increase-cellular-survival-in-stress
#6
Alejandro A Granados, Matthew M Crane, Luis F Montano-Gutierrez, Reiko J Tanaka, Margaritis Voliotis, Peter Swain
Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on fitness is mostly unknown. Here we study budding yeast in dynamic environments of hyperosmotic stress and show how the corresponding signalling network increases cellular survival both by assigning the requirements of high response speed and high response accuracy to two separate input pathways and by having these pathways interact to converge on Hog1, a p38 MAP kinase...
May 17, 2017: ELife
https://www.readbyqxmd.com/read/28512316/phenotypic-plasticity-trade-offs-and-gene-expression-changes-accompanying-dietary-restriction-and-switches-in-bactrocera-dorsalis-hendel-diptera-tephritidae
#7
Er-Hu Chen, Qiu-Li Hou, Dan-Dan Wei, Hong-Bo Jiang, Jin-Jun Wang
In this study, we investigated the effects of dietary restriction (DR) and variable diets on phenotypes and gene expression in oriental fruit fly, Bactrocera dorsalis (Hendel), one of the most economically important pests in the family Tephritidae around the world. As expected, we found that DR altered the B. dorsalis phenotypes by significantly increasing stress resistance and lifespan, but reduced egg production when compared with the control diet. The results suggested a trade-off between reproduction versus somatic maintenance (stress resistance) and lifespan in B...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28512092/quantitative-kinetic-analyses-of-shutting-off-a-two-component-system
#8
Rong Gao, Ann M Stock
Cells rely on accurate control of signaling systems to adapt to environmental perturbations. System deactivation upon stimulus removal is as important as activation of signaling pathways. The two-component system (TCS) is one of the major bacterial signaling schemes. In many TCSs, phosphatase activity of the histidine kinase (HK) is believed to play an essential role in shutting off the pathway and resetting the system to the prestimulus state. Two basic challenges are to understand the dynamic behavior of system deactivation and to quantitatively evaluate the role of phosphatase activity under natural cellular conditions...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28509539/tunable-luminescent-lanthanide-supramolecular-assembly-based-on-photoreaction-of-anthracene
#9
Yan Zhou, Heng-Yi Zhang, Zhi-Yuan Zhang, Yu Liu
Lanthanide luminescence materials generally show great superiority in light-emitting materials, gaining increasingly exploration in the design of advanced functional materials. Herein, we prepared a supramolecular assembly via the coordination of a host molecule (1) and dilanthanide metal. Compound 1 possesses a 9,10-diphenylanthracene (ant) core with photo-sensitivity and terminal terpyridine (tpy), containing two-arm dibenzo-24-crown-8. The assembly could exhibit excellent lanthanide luminescence after un-dergoing a photoreaction from anthracene unit in 1...
May 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28508330/mediators-of-weight-loss-maintenance-in-the-keep-it-off-trial
#10
A L Crain, N E Sherwood, B C Martinson, R W Jeffery
BACKGROUND: An important step toward enhancing the efficacy of weight loss maintenance interventions is identifying the pathways through which successful interventions such as the Keep It Off trial have worked. PURPOSE: This study aimed to assess the viability of mediated relationships between the Keep It Off Guided intervention, conceptually and empirically grounded potential mediators, and weight. Repeated measurement of mediators and weight enabled documentation of the temporal ordering of intervention delivery and changes in mediators and in weight among participants randomized to the Guided intervention or Self-Directed comparison group...
May 15, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28506759/complement-c1q-is-hydroxylated-by-collagen-prolyl-4-hydroxylase-and-is-sensitive-to-off-target-inhibition-by-prolyl-hydroxylase-domain-inhibitors-that-stabilize-hypoxia-inducible-factor
#11
Serafim Kiriakidis, Simon S Hoer, Natalie Burrows, Gloria Biddlecome, Moddasar N Khan, Cyrille C Thinnes, Christopher J Schofield, Norma Rogers, Marina Botto, Ewa Paleolog, Patrick H Maxwell
Complement C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway: a major arm of innate immune defense. C1q is composed of A, B, and C chains that require post-translational prolyl 4-hydroxylation of their N-terminal collagen-like domain to enable the formation of the functional triple helical multimers. The prolyl 4-hydroxylase(s) that hydroxylate C1q have not previously been identified. Recognized prolyl 4-hydroxylases include collagen prolyl-4-hydroxylases (CP4H) and the more recently described prolyl hydroxylase domain (PHD) enzymes that act as oxygen sensors regulating hypoxia-inducible factor (HIF)...
May 12, 2017: Kidney International
https://www.readbyqxmd.com/read/28504796/formation-of-high-molecular-weight-polyaminoborane-by-fe-hydride-catalysed-dehydrocoupling-of-methylamine-borane
#12
F Anke, D Han, M Klahn, A Spannenberg, T Beweries
The complex [(PNHP)Fe(H)(CO)(HBH3)] (PNHP = HN(CH2CH2Pi-Pr2)2) serves as a catalyst precursor for the selective dehydrocoupling of methylamine borane at room temperature, tentatively via an off-metal polymerisation pathway.
May 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28504269/yap-regulates-cell-mechanics-by-controlling-focal-adhesion-assembly
#13
Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin, Giancarlo Forte
Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28503911/community-football-teams-for-people-with-intellectual-disabilities-in-secure-settings-they-take-you-off-the-ward-it-was-like-a-nice-day-and-then-you-get-like-medals-at-the-end
#14
Nicholas Andrew Hudson, Jennifer Hella Mrozik, Rose White, Kristian Northend, Steve Moore, Katherine Lister, Kelly Rayner
BACKGROUND: People with learning disabilities (LD) are particularly vulnerable to mental health and behavioural difficulties, and it has been shown that regular exercise can improve psychosocial well-being as well as physical fitness. This research aims to explore the experiences of men with LD detained in secure settings who have engaged in community football training programmes and identify the benefits of such provision. METHOD: Interviews were conducted with eight patients in a forensic LD service, discussing their experiences of participating in community football...
May 15, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28503130/uncoupling-the-trade-off-between-somatic-proteostasis-and-reproduction-in-caenorhabditis-elegans-models-of-polyglutamine-diseases
#15
Netta Shemesh, Nadav Shai, Lana Meshnik, Rotem Katalan, Anat Ben-Zvi
Caenorhabditis elegans somatic protein homeostasis (proteostasis) is actively remodeled at the onset of reproduction. This proteostatic collapse is regulated cell-nonautonomously by signals from the reproductive system that transmit the commitment to reproduction to somatic cells. Here, we asked whether the link between the reproductive system and somatic proteostasis could be uncoupled by activating downstream effectors in the gonadal longevity cascade. Specifically, we examined whether over-expression of lipl-4 (lipl-4(oe)), a target gene of the gonadal longevity pathway, or increase in arachidonic acid (AA) levels, associated with lipl-4(oe), modulated proteostasis and reproduction...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28502651/rack-1-a-multifaceted-regulator-is-required-for-c-%C3%A2-elegans-innate-immunity-against-s-%C3%A2-flexneri-m9ot-infection
#16
Shanmugam Marudhupandiyan, Udayakumar Prithika, Boopathi Balasubramaniam, Krishnaswamy Balamurugan
The nematode C. elegans has the ability to clear off bacterial colonization in the intestine using pathogen specific innate immune response. Here, we show that C. elegans RACK-1 has been vital in determining the survival of worms under specific pathogenic infection. Among various pathogens tested, S. flexneri M9OT (SF) exhibited highest pathogenicity by killing rack-1 mutant worm-VC3013 earlier when compared to WT. The expression level of rack-1 mRNA was found to be decreased and it further indicated that the host translational event appeared to be affected during SF infection...
May 11, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28500854/systematic-analysis-of-coronary-artery-disease-datasets-revealed-the-potential-biomarker-and-treatment-target
#17
Yan Shi, Sijin Yang, Man Luo, Wei-Dong Zhang, Zun-Ping Ke
Coronary artery disease caused about 1 of every 7 deaths in the United States and early prevention was potential to decrease the incidence and mortality. We aimed to figure the genes involving in the coronary artery disease using meta-anlaysis. Five datasets of coronary heart disease from GEO series were retrieved and data preprocessing and quality control were carried out. Moderated t-test was used to decide the differentially expressed genes for a single dataset. And the combined p-value using systematic-analysis methods were conducted using MetaDE...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28500393/association-of-serum-micrornas-with-islet-autoimmunity-disease-progression-and-metabolic-impairment-in-relatives-at-risk-of-type-1-diabetes
#18
Isaac V Snowhite, Gloria Allende, Jay Sosenko, Ricardo L Pastori, Shari Messinger Cayetano, Alberto Pugliese
AIMS/HYPOTHESIS: MicroRNAs (miRNAs) are key regulators of gene expression and novel biomarkers for many diseases. We investigated the hypothesis that serum levels of some miRNAs would be associated with islet autoimmunity and/or progression to type 1 diabetes. METHODS: We measured levels of 93 miRNAs most commonly detected in serum. This retrospective cohort study included 150 autoantibody-positive and 150 autoantibody-negative family-matched siblings enrolled in the TrialNet Pathway to Prevention Study...
May 12, 2017: Diabetologia
https://www.readbyqxmd.com/read/28496125/enhancing-specific-disruption-of-intracellular-protein-complexes-by-hydrocarbon-stapled-peptides-using-lipid-based-delivery
#19
D Thean, J S Ebo, T Luxton, Xue'Er Cheryl Lee, T Y Yuen, F J Ferrer, C W Johannes, D P Lane, C J Brown
Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane permeability. Peptide stapling has been proposed to circumvent these limitations but recent data has suggested that this method does not universally solve the problem of cell entry and can lead to molecules with off target cell lytic properties. To address these issues a library of stapled peptides was synthesized and screened to identify compounds that bound Mdm2 and activated cellular p53...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490572/heterogeneous-resistance-to-quizartinib-in-acute-myeloid-leukemia-aml-revealed-by-single-cell-analysis
#20
Catherine C Smith, Amy Paguirigan, Grace R Jeschke, Kimberly C Lin, Evan Massi, Theodore Tarver, Chen-Shan Chin, Saurabh Asthana, Adam Olshen, Kevin J Travers, Susana Wang, Mark J Levis, Alexander E Perl, Jerald P Radich, Neil P Shah
Genomic studies have revealed significant branching heterogeneity in cancer. Studies of resistance to tyrosine kinase inhibitor (TKI) therapy have not fully reflected this heterogeneity as resistance in individual patients has been ascribed to largely mutually exclusive "on-target" or "off-target" mechanisms in which tumors either retain dependency on the target oncogene or subvert it through a parallel pathway. Using targeted sequencing from single cells and colonies from patient samples, we demonstrate tremendous clonal diversity in the majority of acute myeloid leukemia (AML) patients with activating FLT3 internal tandem duplication (ITD) mutations at the time of acquired resistance to the FLT3 inhibitor quizartinib...
May 10, 2017: Blood
keyword
keyword
26085
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"