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https://www.readbyqxmd.com/read/29245141/a-systematic-review-of-the-state-of-the-literature-on-sexually-exploited-boys-internationally
#1
Melissa Moynihan, Katherine Mitchell, Claire Pitcher, Farinaz Havaei, Max Ferguson, Elizabeth Saewyc
This systematic review assessed the current state of the literature on sexually exploited boys internationally. We aimed to describe what is known about sexual exploitation of boys, identify gaps in the literature, provide implications for practice, and make recommendations for future research. Multiple database searches were conducted using a combination of controlled vocabulary and keywords to capture child and adolescent sexual exploitation. Our search identified 11,099 unique references and excluded studies that did not include male participants less than 18 years old or disaggregate results by relevant age groups and/or by sex...
December 12, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29245094/concomitant-rhomboid-shaped-tibiae-and-fibulae-finger-like-projections-and-orthopedic-management-in-a-new-variant-of-nievergelt-syndrome-a-case-report
#2
Tuna Pehlivanoğlu, Mehmet Demirel, Yavuz Sağlam, Halil İbrahim Balci, Hayati Durmaz
INTRODUCTION: The rare Nievergelt syndrome (NS) is the most severe form of mesomelic dysplasia and is characterized by disproportionate shortness of the limbs. The aim of this case report was to describe the clinical and radiological features of a rare case of NS. PRESENTATION OF CASE: Here we describe a female patient originally presenting with bilateral hand, lower leg, and foot deformities at the age of 10 years old. In addition to the characteristic features of NS, this patient presented with finger-like projections on her heels, bilateral hand anomalies, and atypical facial features...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245059/proteomic-analysis-of-six-and-twelve-month-hippocampus-and-cerebellum-in-a-murine-down-syndrome-model
#3
Guido N Vacano, David S Gibson, Abdullah Arif Turjoman, Jeremy W Gawryluk, Jonathan D Geiger, Mark Duncan, David Patterson
This study was designed to investigate the brain proteome of the Ts65Dn mouse model of Down syndrome. We profiled the cerebellum and hippocampus proteomes of 6- and 12-month-old trisomic and disomic mice by difference gel electrophoresis. We quantified levels of 2082 protein spots and identified 272 (170 unique UniProt accessions) by mass spectrometry. Four identified proteins are encoded by genes trisomic in the Ts65Dn mouse. Three of these (CRYZL11, EZR, and SOD1) were elevated with p-value <0.05, and 2 proteins encoded by disomic genes (MAPRE3 and PHB) were reduced...
November 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29245043/participation-and-needs-of-children-with-developmental-coordination-disorder-at-home-and-in-the-community-perceptions-of-children-and-parents
#4
Emmanuelle Jasmin, Sylvie Tétreault, Nadine Larivière, Jacques Joly
BACKGROUND: The existing literature provides only a partial understanding of the viewpoints of elementary school-aged children with developmental coordination disorder (DCD) regarding their participation and needs. In order to plan and develop health and social services driven by a personalized approach, it is essential to further document their perceptions with those of their parents. AIMS: The aim of the study was to explore the participation and needs of school-aged children with DCD at home and in the community, as perceived by children and parents...
December 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29245039/prenatal-arsenic-exposure-child-marriage-and-pregnancy-weight-gain-associations-with-preterm-birth-in-bangladesh
#5
Mohammad L Rahman, Molly L Kile, Ema G Rodrigues, Linda Valeri, Anita Raj, Maitreyi Mazumdar, Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Russ Hauser, Andrea Baccarelli, Liming Liang, David C Christiani
BACKGROUND: Preterm birth is a disease of multifactorial etiologies that has environmental, social, and maternal health components. Individual studies have shown that exposure to arsenic contaminated drinking water, child marriage, and low maternal weight gain during pregnancy contribute to preterm birth. These factors are highly prevalent and often co-exist in Bangladesh, a country in South Asia with one of the world's highest prevalences of preterm birth. OBJECTIVE: To evaluate the individual and interactive effects of prenatal arsenic exposure, child marriage, and pregnancy weight gain on preterm birth in a prospective birth cohort in Bangladesh...
December 12, 2017: Environment International
https://www.readbyqxmd.com/read/29244908/changes-in-coping-and-social-motives-for-drinking-and-alcohol-consumption-across-the-menstrual-cycle
#6
Kayla M Joyce, Amanda Hudson, Roisin O'Connor, Kara Thompson, Megan Hodgin, Tara Perrot, Sherry H Stewart
BACKGROUND: Alcohol use has been reported to fluctuate over women's menstrual cycles (MCs), with increased intake occurring premenstrually/menstrually (phases characterized by heightened negative affect) and during the ovulatory phase (a phase characterized by positive affect). This suggests women may drink for particular emotion-focused reasons at specific points in their cycles. However, no research had yet examined MC variability in drinking motives, or links between cycle-related changes in drinking motives and alcohol consumption...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244875/effect-of-age-and-stereopsis-on-a-multiple-object-tracking-task
#7
Marjolaine Plourde, Marie-Eve Corbeil, Jocelyn Faubert
3D vision develops during childhood and tends to diminish after 65 years of age. It is still relatively unknown how stereopsis is used in more complex/ecological contexts such as when walking about in crowds where objects are in motion and occlusions occur. One task that shares characteristics with the requirements for processing dynamic crowds is the multiple object-tracking task (MOT). In the present study we evaluated the impact of stereopsis on a MOT task as a function of age. A total of 60 observers consisting of three groups of 20 subjects (7-12 years old, 18-40 years old and 65 years and older) completed the task in both conditions (with and without stereoscopic effects)...
2017: PloS One
https://www.readbyqxmd.com/read/29244847/cognitive-failures-in-late-adulthood-the-role-of-age-social-context-and-depressive-symptoms
#8
Paul Kenneth Hitchcott, Maria Chiara Fastame, Dalila Langiu, Maria Pietronilla Penna
The incidence of self-reported cognitive failures among older adults may be an index of successful cognitive aging. However, self-reported cognitive failures are biased by variation in depressive symptomatology. This study examined age-related and socio-cultural context effects on cognitive failures while controlling for depressive symptoms. Both overall and specific factors of cognitive failures were determined. A further goal was to investigate the relationship between working memory and cognitive efficiency measures and cognitive failures...
2017: PloS One
https://www.readbyqxmd.com/read/29244837/frailty-and-quality-of-life-among-older-people-with-and-without-a-cancer-diagnosis-findings-from-topics-mds
#9
Noralie Geessink, Yvonne Schoon, Harry van Goor, Marcel Olde Rikkert, René Melis
BACKGROUND: The number of older cancer patients is rising. Especially in older people, treatment considerations should balance the impact of disease and treatment on quality of life (QOL) and survival. How a cancer diagnosis in older people interacts with concomitant frailty to impact on QOL is largely unknown. We aimed to determine the association between frailty and QOL among community-dwelling older people aged 65 years or above with and without a cancer diagnosis cross-sectionally and at 12 months follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/29244811/impact-of-increased-influenza-vaccination-in-2-3-year-old-children-on-disease-burden-within-the-general-population-a-bayesian-model-based-approach
#10
Sankarasubramanian Rajaram, Witold Wiecek, Richard Lawson, Betina T Blak, Yanli Zhao, Judith Hackett, Robert Brody, Vishal Patel, Billy Amzal
INTRODUCTION: During the 2013-2014 influenza season, Public Health England extended routine influenza vaccination to all 2- and 3-year-old children in England. To estimate the impact of this change in policy on influenza-related morbidity and mortality, we developed a disease transmission and surveillance model informed by real-world data. METHODS: We combined real-world and literature data sources to construct a model of influenza transmission and surveillance in England...
2017: PloS One
https://www.readbyqxmd.com/read/29244802/elevations-of-inflammatory-proteins-in-neonatal-blood-are-associated-with-obesity-and-overweight-among-2-year-old-children-born-extremely-premature
#11
Eliana M Perrin, T Michael O'Shea, Asheley Cockrell Skinner, Carl Bose, Elizabeth N Allred, Raina N Fichorova, Jelske W van der Burg, Alan Leviton
BACKGROUND: Childhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity. METHODS: In a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age. RESULTS: Among children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244791/management-and-outcomes-of-childhood-goodpasture-s-disease
#12
Carmela P Menzi, Barbara S Bucher, Mario G Bianchetti, Gianluigi Ardissino, Giacomo D Simonetti
BACKGROUND: In an attempt to improve knowledge about childhood Goodpasture's disease, we performed a retrospective analysis of patients with Goodpasture's disease from several pediatric nephrology centers. METHODS: We analyzed the responses to 27 questions that elicited information about the following: incidence, demographics, patient history and clinical presentation, diagnostics performed, acute and chronic therapy, course of disease and outcome. RESULTS: Goodpasture's disease, which is extremely rare in this age group, may manifest in 2-year-old toddlers and does not typically present with pulmonary findings before puberty...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244749/serum-levels-of-s100b-and-nse-proteins-in-patients-with-non-transfusion-dependent-thalassemia-as-biomarkers-of-brain-ischemia-and-cerebral-vasculopathy
#13
Aikaterini Kanavaki, Konstantinos Spengos, Maria Moraki, Polyxeni Delaporta, Catherine Kariyannis, Ioannis Papassotiriou, Antonis Kattamis
Patients with non-transfusion-dependent thalassemia (NTDT) are at risk of developing brain ischemia. Transcranial Doppler (TCD) has been established as a useful screening tool of cerebrovascular disease in patients with sickle cell disease. Proteins neuron specific enolase (NSE) and S100B are biomarkers that reflect CNS injury. The purpose of this study is to evaluate cerebral vessel vasculopathy and brain damage in NTDT patients using non-invasive methods as TCD and measurement serum levels of NSE and S100B...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244736/frequency-of-fruit-and-vegetable-consumption-and-the-oral-health-related-quality-of-life-among-japanese-elderly-a-cross-sectional-study-from-the-kyoto-kameoka-study
#14
Hinako Nanri, Yosuke Yamada, Aya Itoi, Emi Yamagata, Yuya Watanabe, Tsukasa Yoshida, Motoko Miyake, Heiwa Date, Kazuko Ishikawa-Takata, Mitsuyoshi Yoshida, Takeshi Kikutani, Misaka Kimura
OBJECTIVE: Many previous studies have reported that fruit and vegetable consumption is associated with a reduced risk of various disease, but whether or not their consumption is associated with the oral health-related quality of life (OHRQoL) is unclear. The objective of this study was to examine the association between the frequency of fruit and vegetable consumption and the OHRQoL in elderly subjects by sex. METHODS: We analyzed cross-sectional data from a population-based Kyoto-Kameoka Study in 2012 of 3112 men and 3439 women (age ≥ 65 years)...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244706/streptococcus-pneumoniae-osteomyelitis-in-a-25-year-old-man-as-the-initial-presentation-of-multiple-myeloma-a-case-report
#15
Tracy Webber, Michael Lawlor, Tessa Balach
CASE: We report the case of a 25-year-old man with femoral Streptococcus pneumoniae pyomyositis as well as hypercalcemia, mild anemia, and elevated inflammatory markers; he subsequently was diagnosed with immunoglobulin G (IgG) kappa multiple myeloma. CONCLUSION: Multiple myeloma most commonly affects patients who are >60 years of age, and causes clinical symptoms from anemia, lytic bone lesions, hypercalcemia, and renal failure. These findings and a monoclonal protein spike serve as initial diagnostic and treatment criteria...
July 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244704/nonunion-of-a-nondisplaced-radial-neck-fracture-a-case-report
#16
John G Coury, Zachary C Lum, Marc A Trzeciak
CASE: We describe the case of a 66-year-old man who sustained a nondisplaced radial neck fracture and subsequently developed a symptomatic nonunion. After a period of unsuccessful conservative treatment, a radial head resection was performed. CONCLUSION: Radial neck fractures, unlike their radial head counterparts, have a low rate of nonunion. Our patient's only positive risk factor was age, but he developed a nonunion. At the 2-year follow-up after excision of the radial head, there was a lack of proximal migration of the radius during axial loading, demonstrating a positive outcome without the need for replacement of the radial head...
July 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244611/learning-new-letter-like-writing-patterns-explicitly-and-implicitly-in-children-and-adults
#17
M Jongbloed-Pereboom, A Overvelde, M W G Nijhuis-van der Sanden, B Steenbergen
A handwriting task was used to test the assumption that explicit learning is dependent on age and working memory, while implicit learning is not. The effect of age was examined by testing both, typically developing children (5-12 years old, n = 81) and adults (n = 27) in a counterbalanced within-subjects design. Participants were asked to repeatedly write letter-like patterns on a digitizer with a non-inking pen. Reproduction of the pattern was better after explicit learning compared to implicit learning. Age had positive effects on both explicit and implicit learning; working memory did not affect learning in either conditions...
December 15, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29244245/substance-p-in-dorsal-root-ganglion-neurons-in-young-and-adult-rats-after-nociceptive-stimulation-during-the-neonatal-period
#18
Ana Leda Bertoncini Simões, Greice Anne Rodrigues Silva, Carolina Giorgetto, Elisabete de Cassia do Carmo-Campos, Fernando José Dias, Valéria Paula Sassoli Fazan
The nervous system is highly plastic during the neonatal period, being sensitive to noxious stimuli, which may cause short- and long-term pain responsivity changes. Understanding plasticity in peripheral pain pathways is crucial, particularly when the nervous system is still under development and remodeling process. Substance P (SP) is widely used as a marker for peripheral neurons with unmyelinated and small myelinated fibers. We investigated the number of SP immunoreactive neurons in the dorsal root ganglion (DRG) of male and female Wistar rats, 15 and 180 days after nociceptive stimulation during the neonatal period...
December 15, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29244218/person-specific-contribution-of-neuropathologies-to-cognitive-loss-in-old-age
#19
Patricia A Boyle, Lei Yu, Robert S Wilson, Sue E Leurgans, Julie A Schneider, David A Bennett
OBJECTIVE: Mixed neuropathologies are the most common cause of dementia at the population level, but how different neuropathologies contribute to cognitive decline at the individual level remains unknown. We quantified the contribution of nine neuropathologies to cognitive loss at an individual level. METHODS: Participants (n=1,079) came from 2 longitudinal clinical-pathologic studies of aging. All completed 2+ cognitive evaluations (maximum = 22), died and underwent neuropathologic examinations to identify Alzheimer's disease (AD), other neurodegenerative diseases, and vascular pathologies...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29244176/parvovirus-b19-is-associated-with-a-significant-decrease-in-hemoglobin-level-among-children-5-years-of-age-with-anemia-in-northwestern-tanzania
#20
Yustina A Tizeba, Mariam M Mirambo, Neema Kayange, Tumaini Mhada, Emmanuela E Ambrose, Luke R Smart, Stephen E Mshana
Parvovirus B19 (B19) can cause transient aplastic crisis and lead to acute severe anemia. This study investigated the relationship between B19 and anemia among children <5 years old in the city of Mwanza, Tanzania. An enzyme immunoassay was used to detect B19 IgM- and IgG-specific antibodies among children with various categories of anemia according to the World Health Organization (WHO) guidelines. A total of 265 children with median age of 28.5 months (interquartile range 18-39.5) were investigated. Eighty-six children (32...
December 13, 2017: Journal of Tropical Pediatrics
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