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Old age

Noa Rymer-Haskel, Irit Schushan-Eisen, Yigal Hass, Roni Rahav, Ayala Maayan-Metzger, Israel Hendler
INTRODUCTION: Advanced maternal age (AMA) is associated with increased risk for preeclampsia, however, a paucity of data exists regarding the characteristics of the disease in this age group. Our aim was to compare the characteristics and severity of preeclampsia in older and younger gravidas. MATERIALS & METHODS: A retrospective, small case control study of women diagnosed with preeclampsia in a single tertiary care center. Nulliparous women ≥40 years old with singleton pregnancies ≥ 24 0/7 weeks' gestation were matched (1:2 ratio) with young (20-34 years old) nulliparous women...
June 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
S Ganhão-Arranhado, C Paúl, R Ramalho, P Pereira
Nutritional status is important to elders to live without disabilities. Food Insecurity (FI) is a risk factor associated with poorer nutritional status among elderly as well as a social determinant. This research aimed to identify FI prevalence and to explore the relation between FI, weight status and socio-demographic factors. METHODS: This cross-sectional study was conducted from September 2015 to February 2016 in Lisbon. Malnutrition was determined using Mini Nutritional Assessment (MNA)...
June 13, 2018: Archives of Gerontology and Geriatrics
Pierre Bertho, Adrien Pauvert, Thomas Pouderoux, Henri Robert
BACKGROUND: Osteo-chondral defects due to advanced osteochondritis of the knee eventually cause osteoarthritis. Autologous matrix-induced chondrogenesis (AMIC) may hold potential for overcoming the treatment challenges raised by defects larger than 2 cm2 . The primary objective of this study was to assess medium-term functional outcomes of AMIC. The secondary objective was to confirm the absence of adverse events. HYPOTHESIS: AMIC significantly improves knee function in patients with osteochondritis responsible for osteo-chondral defects grade III or IV in the International Cartilage Repair Society (ICRS) classification...
June 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Zhiping Yu, Natalie Arce Indelicato, Paul Fuglestad, Michael Tan, Lindsay Bane, Caitlin Stice
This cross-sectional study aimed to assess sex differences and weight status differences in disordered eating behaviors (DEB) and food addiction (FA) along with their co-occurrence among college students. Self-reported demographic and weight information, the Eating Attitude Test (EAT-26), and Yale Food Addiction Scale (YFAS) were collected from 965 college students. Participants included 703 (72.8%) female, 720 (74.8%) white, and ranged in age from 18 to 25 years old. Female college students had a significantly higher prevalence of DEB (11...
June 20, 2018: Appetite
Katie S Murray, Massimiliano Spaliviero, Emily S Tonorezos, Mario E Lacouture, William D Tap, Kevin C Oeffinger, Hebert Alberto Vargas, James A Eastham
OBJECTIVES: To report a case of pelvic angiosarcoma in a 27-year-old man with Li-Fraumeni Syndrome (LFS) and evaluate the presentation and timeline of genitourinary (GU) tract involvement in LFS patients. METHODS: We retrospectively identified 39 LFS patients treated at our institution between 2000 and 2014; 7 (18%) had experienced a GU malignancy or an LFS-related malignancy involving the GU tract. Clinical characteristics, including dates of onset of first GU tract malignancies; pathologic findings; multimodal management; and familial history of LFS were reviewed...
June 20, 2018: Urology
Yanqin Lu, Xiuzhi Ren, Yanzhou Wang, Ghalib Bardai, Marc Sturm, Yunzhang Dai, Olaf Riess, Yao Zhang, Hu Li, Tianyou Li, Naixiang Zhai, Jian Zhang, Frank Rauch, Jinxiang Han
INTRODUCTION: Biallelic mutations in WNT1 can give rise to a rare form of moderate to severe OI. Here we report on 12 children (age 2 to 16 years; 5 girls) with biallelic WNT1 mutations. METHODS: Genomic DNA was analyzed either by targeted next-generation sequencing or Sanger sequencing. Mutations were modeled on the WNT1 protein structure. The in vitro functional effect of WNT1 mutations on WNT signaling was assessed in HEK293 cells using the topflash reporter assay system...
June 20, 2018: Bone
Andrea Giacomini, Fiorenza Stagni, Marco Emili, Sandra Guidi, Maria Elisa Salvalai, Mariagrazia Grilli, Veronica Vidal-Sanchez, Carmen Martinez-Cué, Renata Bartesaghi
Individuals with Down syndrome (DS), a genetic condition due to triplication of Chromosome 21, are characterized by intellectual disability that worsens with age. Since impairment of neurogenesis and dendritic maturation are very likely key determinants of intellectual disability in DS, interventions targeted to these defects may translate into a behavioral benefit. While most of the neurogenesis enhancers tested so far in DS mouse models may pose some caveats due to possible side effects, substances naturally present in the human diet may be regarded as therapeutic tools with a high translational impact...
June 20, 2018: Brain Research Bulletin
Igor C Borges, Dafne C Andrade, Nina Ekström, Camilla Virta, Merit Melin, Annika Saukkoriipi, Maija Leinonen, Olli Ruuskanen, Helena Käyhty, Cristiana M Nascimento-Carvalho
The aim of this study was to compare the results of serological assays using pneumococcal proteins or polysaccharides for the detection of pneumococcal infection in childhood pneumonia. Serological assays measured IgG against eight pneumococcal proteins (Ply,CbpA,PspA1,PspA2,PcpA,PhtD,StkP-C,PcsB-N), C-polysaccharide [in the whole study population, n = 183], or 19 pneumococcal capsular polysaccharides (1,2,4,5,6B,7F,8,9 V,10A,11A,12F,14,15B,17F,18C,19F,20,23F,33F) [only in a subgroup of patients, n = 53] in paired serum samples of children aged <5 years-old hospitalized with clinical and radiological diagnosis of community-acquired pneumonia...
June 20, 2018: Journal of Immunological Methods
Chiara Cavalli, Vincenzo Tarzia, Massimo Marini, Dario Gregori, Silvia Casella, Tomaso Bottio, Giuseppe Toscano, Angela Pompea Fraiese, Antonio Gambino, Biancarosa Volpe, Gino Gerosa
BACKGROUND: the aim of the current study was to evaluate and compare the quality of life (QOL) and psychological status of adult patients who underwent heart transplant (HTx) at pediatric or adult ages. METHODS: The population consisted of two groups: patients who received HTx after 18 years-old, pediatrics who received HTx between the age of 1 and 18 years. At the time of the study all patients were over 18 years old. QOL data were collected from patients using 36-item Short Form Health Survey (SF-36) and psychological-distress by the Symptom checklist 90-revised questionnaire (SCL-90-R)...
June 23, 2018: Clinical Transplantation
A Haehner, T Hummel, W Heinritz, S Krueger, M Meinhardt, K L Whitcroft, R Sabatowski, G Gossrau
Mutations in the sodium-channel Nav 1.7, encoded by the gene SCN9A, are known to cause pain disorders. In particular, gain-of-function missense mutations in Nav 1.7 have been shown to be causal in primary erythromelalgia. We present a patient with erythromelalgia, pain attacks and hyperosmia with a mutation within the sodium channel gene SCN9A. A 50-year-old woman presented with burning pain in both feet and abdominal pain attacks developed over the course of 10 years. Furthermore, this patient experienced a hypersensitivity for odors...
June 23, 2018: European Journal of Pain: EJP
Arwa Younis, Ella Shaviv, Eyal Nof, Ariel Israel, Anat Berkovitch, Ilan Goldenberg, Michael Glikson, Robert Klempfner, Roy Beinart
BACKGROUND: Atrial fibrillation (AF) is associated with diminished cardiac function, and exercise tolerance. HYPOTHESIS: We sought to investigate the role of cardiac rehabilitation program (CR) in patients with AF. METHODS: The study included 2165 consecutive patients that participated in our CR program between the years 2009 - 2015. All were evaluated by a standard exercise stress test (EST) at baseline, and upon completion of at least 3 months of training...
June 23, 2018: Clinical Cardiology
X Serra-Aracil, S Serra-Pla, L Mora-Lopez, A Pallisera-Lloveras, M Labro-Ciurans, S Navarro-Soto
BACKGROUND: Although the incidence of colorectal cancer increases with the patient's age, the elderly continue to be less likely to be scheduled for surgery. Transanal endoscopic micro-surgery (TEM) is a surgical alternative to total mesorectal excision (TME) in early stage rectal cancer and/or in selected patients that could decrease morbidity and mortality rates in this group of patients. Our main objective is to assess the safety and feasibility of TEM in elderly (75-84 years) and very elderly (≥ 85 years) patients...
June 22, 2018: Surgical Endoscopy
Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Giustino Orlando, Michele Vacca, Roberto Salvatori, Luigi Brunetti
BACKGROUND: Growth hormone-releasing hormone (GHRH) plays an important role in brain functions. The aim of this study was to examine cognitive functions and emotional behaviour in a mouse model of isolated GH deficiency due to bi-allelic ablation of the GHRH gene (GHRH knockout, GHRHKO). METHODS: Learning, memory and emotional behaviour were evaluated using a series of validated tests (Morris water maze, eight-arm radial maze, open field, elevated plus maze test, forced swim tests) in 2, 5, and 12 months old male mice either homozygous (-/-) or heterozygous (+/-) for the GHRHKO allele...
June 22, 2018: Endocrine Connections
Po-Wen Ku, Andrew Steptoe, Yun-Ju Lai, Hsiao-Yun Hu, Dachen Chu, Yung-Feng Yen, Yung Liao, Li-Jung Chen
OBJECTIVE: This nationwide population-based study aimed to examine the prospective association between near visual activities and incident myopia in Taiwanese children 7 to 12 years old over a 4-year follow-up period. DESIGN: Prospective cohort design. PARTICIPANTS: There were 1958 children aged 7 to 12 years from the Taiwan 2009 National Health Interview Survey who were linked to the 2009 through 2013 claims data from the National Health Insurance system...
June 19, 2018: Ophthalmology
Nanya Wang, Yabing Dong, Lingling Zhao, Hengjun Zhao, Wei Li, Jiuwei Cui
PURPOSE: To analyze clinical factors that were associated with inadequate pain control in cancer patients with metastatic malignancy and moderate to severe baseline pain. PATIENTS: We retrospectively analyzed data from 260 advanced cancer patients who admitted to the First Hospital of Jilin University (Jilin, China) from January 2012-May 2013. MEASUREMENTS: Statistical analysis was performed to assess the correlation between pain control and baseline characteristics including, gender, patient age, type of malignancy, presence of bone metastases, pain intensity, pain location, etiology of pain, type of pain, and presence of breakthrough pain...
May 24, 2018: Current Problems in Cancer
Thiago Cardoso Vale, Maira Tonidandel Barbosa, Elisa de Paula França Resende, Débora Palma Maia, Mauro César Quintão Cunningham, Henrique Cerqueira Guimarães, João Carlos Barbosa Machado, Antônio Lucio Teixeira, Francisco Cardoso, Paulo Caramelli
INTRODUCTION: Parkinsonism is one of the most prevalent neurological syndromes in the elderly. There are only a few epidemiological studies focusing on parkinsonism in oldest-old individuals, particularly in Latin America. This study aims to investigate the prevalence and characteristics of parkinsonism in subjects aged 75 + years living in the community. METHODS: The Pietà study is a population-based investigation on brain aging conducted in Caeté, southeast Brazil...
June 19, 2018: Parkinsonism & related Disorders
Lorre S Atlan, Ingrid S Lan, Colin Smith, Susan S Margulies
BACKGROUND: Traumatic brain injury is a leading cause of cognitive and behavioral deficits in children in the US each year. None of the current diagnostic tools, such as quantitative cognitive and balance tests, have been validated to identify mild traumatic brain injury in infants, adults and animals. In this preliminary study, we report a novel, quantitative tool that has the potential to quickly and reliably diagnose traumatic brain injury and which can track the state of the brain during recovery across multiple ages and species...
June 1, 2018: Clinical Biomechanics
Noralie H Geessink, Eirik H Ofstad, Marcel G M Olde Rikkert, Harry van Goor, Jürgen Kasper, Yvonne Schoon
OBJECTIVE: To identify determinants of older patients' perceptions of involvement in decision-making on colorectal (CRC) or pancreatic cancer (PC) treatment, and to compare these with determinants of observers' perceptions. METHODS: Patients' perceptions of involvement were constructed by the 9-item SDM questionnaire (SDM-Q-9) and a Visual Analogue Scale for Involvement (VAS-I). Observers' perceptions were constructed by the OPTION5, OPTION12, and MAPPIN'SDM. Convergent validities were calculated between the patient-sided and observer instruments using Spearman's correlation coefficient...
June 13, 2018: Patient Education and Counseling
Özgen Alpay Özbek, İbrahim Mehmet Ali Öktem, Can Hüseyin Hekimoğlu, Özgür Sekreter, Mestan Emek, Gonca Atasoylu, Ayla Açıkgöz, Nur Demirpençe, Ali Ceylan, Elif Sanem Baykal, Belgin Ünal
Vaccination is the most effective way of preventing pertussis disease. Turkey commenced a routine infant immunization program using whole cell (wP) pertussis vaccine in 1968. Immunization accelerated in 1985 after participation of Turkey in the Expanded Programme on Immunization initiated by the World Health Organization. Acellular vaccine (aP) replaced wP in 2008 and a booster was added to age 6 in 2010. The immunization programme was successful in reducing the morbidity rate from 20.58 per 100.000 in 1970 to the lowest level of 0...
April 2018: Mikrobiyoloji Bülteni
William G Kronenberger, Shirley C Henning, Allison M Ditmars, Adrienne S Roman, David B Pisoni
OBJECTIVE: Deaf children with cochlear implants (CIs) show poorer verbal working memory compared to normal-hearing (NH) peers, but little is known about their verbal learning and memory (VLM) processes involving multi-trial free recall. DESIGN: Children with CIs were compared to NH peers using the California Verbal Learning Test for Children (CVLT-C). STUDY SAMPLE: Participants were 21 deaf (before age 6 months) children (6-16 years old) implanted prior to age 3 years, and 21 age-IQ matched NH peers...
June 22, 2018: International Journal of Audiology
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