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https://www.readbyqxmd.com/read/29471570/-differentiated-drug-therapy-especially-important-in-old-age
#1
Erland Erdmann
No abstract text is available yet for this article.
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471551/bilateral-striatal-necrosis-after-sydenham-s-chorea-in-a-7-year-old-boy-a-2-year-follow-up
#2
C Canavese, C Davico, M Casabianca, C Olivieri, S Mancini, G Migliore, A Versace, A Tocchet, B Vitiello
Child bilateral striatal necrosis (BSN) is a rare and etiologically heterogeneous condition. An association with group A streptococcus (GAS) infection was previously reported in two cases of BSN in infancy and early childhood. We here report on a 7-year-old boy who developed chorea and dystonia 20 days after symptomatic recovery from Sydenham's chorea. Repeated brain magnetic resonance imaging scans, obtained before, soon after the onset of the post-Sydenham symptoms, and 1 year later were consistent with an evolution from bilateral striatal microbleeding to necrosis, and consequently reduced basal ganglia volume and enlargement of the frontal horns...
February 22, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29471511/sexual-dimorphism-in-the-behavioral-responses-and-the-immunoendocrine-status-in-d-galactose-induced-aging
#3
Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia Giménez-Llort
For almost twenty years, chronic systemic D-galactose, a monosaccharide abundantly present in milk products, fruits and vegetables, has been used as a tool to achieve models of accelerated aging. Its neurotoxicity, induced by abnormal accumulation of ROS and AGEs, has been widely reported. However, behavioral outcomes are still controversial and little is known about sex-dependent vulnerability. We performed a comprehensive behavioral and multi-functional screening of the chronic effects of low (50 mg/kg) and high (100 mg/kg) doses of D-galactose in 6-month-old male and female gold-standard C57BL/6 mice...
February 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29471463/metapragmatic-explicitation-and-social-attribution-in-social-communication-disorder-and-developmental-language-disorder-a-comparative-study
#4
Catherine Adams, Elaine Lockton, Anna Collins
Purpose: The purposes of this study are to investigate metapragmatic (MP) ability in 6-11-year-old children with social communication disorder (SCD), developmental language disorder (DLD), and typical language development and to explore factors associated with MP explicitation and social understanding (SU). Method: In this cross-sectional study, all participants (N = 82) completed an experimental task, the Assessment of Metapragmatics (Collins et al., 2014), in which pragmatic errors are identified in filmed interactions...
February 22, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29471335/after-70-years-of-fighting-an-age-old-scourge-onchocerciasis-in-uganda-the-end-is-in-sight
#5
Moses N Katabarwa, Thomson Lakwo, Peace Habomugisha, Thomas R Unnasch, Rolf Garms, Lauri Hudson-Davis, Edson Byamukama, Annet Khainza, Johnson Ngorok, Edridah Tukahebwa, Frank O Richards
Onchocerciasis causes severe itching, serious skin disease and ocular damage leading to visual impairment or permanent blindness. It is associated with hanging groin, epilepsy, Nakalanga dwarfism and, most recently, nodding disease. This disease affected communities in 17 transmission foci in 37 districts of Uganda, where about 6.7 million people are once at risk. The efforts against onchocerciasis in Uganda commenced in the late 1940s, when vector control was launched using dichlorodiphenyltrichloroethane; by 1973, Simulium damnosum had been eliminated in the Victoria focus...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29471213/cerebellar-gray-matter-explains-bimanual-coordination-performance-in-children-and-older-adults
#6
Matthieu P Boisgontier, Boris Cheval, Peter van Ruitenbeek, Koen Cuypers, Inge Leunissen, Stefan Sunaert, Raf Meesen, Hamed Zivari Adab, Olivier Renaud, Stephan P Swinnen
The cerebellum appears to undergo late maturation in children and early decline at older age. Whether these age-related changes affect bimanual coordination performance remains unclear at best. Here, we identified the ages at which bimanual coordination performance stops improving and starts declining. In an independent cohort, we defined brain regions of interest involved in bimanual coordination using functional magnetic resonance imaging. We used these regions of interest to investigate the extent to which the gray matter of cerebellar and other brain regions explains bimanual coordination performance from 10- to 80-year-olds...
February 2, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29471212/nodular-fasciitis-mimicking-a-soft-tissue-sarcoma-a-case-report
#7
Vatsal Khanna, Manikandan Rajan, Trishya Reddy, Naveen Alexander, Parmasivam Surendran
INTRODUCTION: Nodular Fasciitis, also known as infiltrative or pseudosarcomatous fasciitis, is a benign soft tissue tumour of fibroblastic/myofibroblastic differentiation, that was first described in 1955 by Konwaler et al. PRESENTATION OF CASE: This is a case report of a 27-year old male with complaints of a swelling in the right axilla for 2 and ½ years measuring 12 cm × 10 cm. Chest X-Ray was normal. Magnetic Resonance Imaging of the right arm and chest showed an irregular mass in the axilla in the muscular-subcutaneous plane measuring 10...
February 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29471185/the-attention-training-technique-improves-children-s-ability-to-delay-gratification-a-controlled-comparison-with-progressive-relaxation
#8
Joanne Murray, Helen Scott, Claire Connolly, Adrian Wells
The ability to delay gratification at a young age is a predictor of psychological, cognitive, health, and academic later-life outcomes. This study aimed to extend earlier research and explore whether a metacognitive intervention, Wells' (1990) Attention Training Technique (ATT), could improve young children's ability to delay gratification compared to an active-control (Progressive Muscle Relaxation: PMR), and no-intervention group. One hundred and one children aged 5-6 years old were recruited from schools...
February 15, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29471180/linking-financial-hardship-throughout-the-life-course-with-psychological-distress-in-old-age-sensitive-period-accumulation-of-risks-and-chain-of-risks-hypotheses
#9
Alexander Darin-Mattsson, Ross Andel, Roger Keller Celeste, Ingemar Kåreholt
The primary objective was to investigate the life course hypotheses - sensitive period, chain of risks, and accumulation of risks - in relation to financial hardship and psychological distress in old age. We used two Swedish longitudinal surveys based on nationally representative samples. The first survey includes people 18-75 years old with multiple waves, the second survey is a longitudinal continuation, including people 76 + years old. The analytical sample included 2990 people at baseline. Financial hardship was assessed in childhood (retrospectively), at the mean ages of 54, 61, 70, and 81 years...
February 17, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29471160/persistent-first-intersegmental-artery-pfia-visualized-by-three-dimensional-computed-tomography-angiography-in-chinese-population
#10
Haocong Zhang, Wei Chai, Shuang Wang, Yan Wang, Hongwei Li
BACKGROUND: Persistent first intersegmental artery (PFIA) is one of the most frequently vertebral artery (VA) variations. The presence of PFIA obviously increases the complexity and difficulty of vertebral lesion treatment. Thus, preoperative detection of PFIA is necessary to increase the successful rate of surgeries. We attempted to evaluate the utility value of three-dimension (3D) computed tomography angiography (CTA) for detecting PFIA in the north Chinese population. MATERIALS AND METHODS: Consecutive patients subjected to CTA between June 2012 and March 2014 were recruited from 5 clinical centers in the north of China...
February 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29471104/cellular-senescence-as-a-therapeutic-target-to-improve-renal-transplantation-outcome
#11
REVIEW
Hester van Willigenburg, Peter L J de Keizer, Ron W F de Bruin
Kidney transplants from aged donors are more vulnerable to ischemic injury, suffer more from delayed graft function and have a lower graft survival compared to kidneys from younger donors. On a cellular level, aging results in an increase in cells that are in a permanent cell cycle arrest, termed senescence, which secrete a range of pro-inflammatory cytokines and growth factors. Consequently, these senescent cells negatively influence the local milieu by causing inflammaging, and by reducing the regenerative capacity of the kidney...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29471052/revisiting-rabies-virus-neutralizing-antibodies-through-infecting-balb-c-mice-with-live-rabies-virus
#12
Yunlong Qin, Todd G Smith, Felix Jackson, Nadia F Gallardo-Romero, Clint N Morgan, Victoria Olson, Christina L Hutson, Xianfu Wu
This study investigates the production of rabies virus (RABV) neutralizing antibody after virus infection through a mouse model. The BALB/c mice from different age groups (three, five, seven week old) were intramuscularly inoculated with live rabies virus (TX coyote 323R). Without pre-exposure or post-exposure prophylaxis (PEP), we found there is a decreased fatality with increased age of animals, the mortalities are 60%, 50%, and 30%, respectively. Interestingly, through assay of rapid fluorescent focus inhibition test (RFFIT), direct fluorescent antibody (DFA) and quantitative Polymerase Chain Reaction (qPCR), the results showed that all the animals that succumbed to rabies challenge, except one, developed circulating neutralizing antibodies, and all the healthy animals, except two, did not generate virus neutralizing antibodies (VNA)...
February 19, 2018: Virus Research
https://www.readbyqxmd.com/read/29470971/use-of-autologous-serum-tears-for-the-treatment-of-ocular-surface-disease-from-patients-with-systemic-autoimmune-diseases
#13
Tayyeba K Ali, Allister Gibbons, Cristián Cartes, Siamak Zarei-Ghanavati, Mohamed Gomaa, Ingrid Gonzalez, Astrid E Gonzalez, Hilal E Ozturk, Carolina Betancurt, Victor L Perez
PURPOSE: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). DESIGN: Retrospective, interventional case series. METHODS: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK) and corneal epithelial defects (KED) were compared during first and last visit...
February 19, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29470802/male-undergraduates-hpv-vaccination-behavior-implications-for-achieving-hpv-associated-cancer-equity
#14
Hee Yun Lee, Katherine Lust, Suzanne Vang, Jay Desai
Despite the availability of the human papillomavirus (HPV) vaccine for males, uptake of the vaccine has been low, particularly among young adult males. This study aimed to investigate the levels of HPV vaccination and predictors of HPV vaccine completion in college men ages 18-26. We analyzed data from the 2015 College Student Health Survey, which was administered at 17 post-secondary institutions in Midwest areas. We included only responses from male participants who were ages 18-26 years old, resulting in a sample size of 2516...
February 22, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29470740/effect-of-supplementing-germinated-sprouts-of-pulses-on-performance-carcass-variables-immune-and-oxidative-stress-indicators-in-broiler-chickens-reared-during-tropical-summer-season
#15
S V Rama Rao, B Prakash, U Rajkumar, M V L N Raju, T Srilatha, E P K Reddy
An experiment was conducted to study the effects of supplementing sprouts of pulses on performance, carcass variables, immune responses, and anti-oxidant variables in broiler chicken (day 1 to 6 weeks of age) reared during summer season in tropical region. Sprouts of black gram (BG, Vigna mungo), green gram (GG, Vigna radiata), and wild gram (WG, Vigna trilobata) were produced by soaking the pulses in water for 16 h and incubating at 37 °C for 24 h. Total phenolic content in sprouts of WG, BG, and GG was 102, 96...
February 22, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29470680/changes-in-skeletal-muscle-and-body-weight-on-sleeping-beauty-transposon-mediated-transgenic-mice-overexpressing-pig-migf-1
#16
Bo Gao, Wei Wang, Han Wu, Cai Chen, Dan Shen, Saisai Wang, Wei Chen, Li Zhang, Shuheng Chan, Chengyi Song
Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic mouse model was generated which can also provide experimental data for making transgenic pigs with pig endogenous IGF1 gene. We constructed a skeletal muscle-specific expression vector using 5'- and 3'-regulatory regions of porcine skeletal α-actin gene...
February 22, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29470431/articular-cartilage-aging-potential-regenerative-capacities-of-cell-manipulation-and-stem-cell-therapy
#17
REVIEW
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek, Adam Osowski, Joanna Wojtkiewicz
Changes in articular cartilage during the aging process are a stage of natural changes in the human body. Old age is the major risk factor for osteoarthritis but the disease does not have to be an inevitable consequence of aging. Chondrocytes are particularly prone to developing age-related changes. Changes in articular cartilage that take place in the course of aging include the acquisition of the senescence-associated secretory phenotype by chondrocytes, a decrease in the sensitivity of chondrocytes to growth factors, a destructive effect of chronic production of reactive oxygen species and the accumulation of the glycation end products...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29470414/the-sitting-height-index-of-build-body-mass-sitting-height-%C3%A2-as-an-improvement-on-the-body-mass-index-for-children-adolescents-and-young-adults
#18
Richard Burton
The body mass index (BMI) is unsatisfactory in being affected by both relative leg length and height, and, for use with children and adolescents, therefore needs to be interpreted in relation to age. The sitting-height index of build (body mass)/(sitting height)³, is largely free of these disadvantages. Furthermore, because that index is independent of relative leg length, the latter can be treated as a separate indicator of nutritional history and health risks. Past studies on white children and adults have shown body mass to be approximately proportional to (sitting height)³...
February 22, 2018: Children
https://www.readbyqxmd.com/read/29469790/jessner-lymphocytic-infiltration-rare-in-childhood
#19
Martine Prütz Petersen, Vibeke Vestergaard, Anette Bygum
We present a 13-year-old girl with Jessner lymphocytic infiltrate of the skin, who has suffered from the disease since the age of 9 years. It is a rare disease in childhood, and we highlight the clinical features and therapeutic response of tacrolimus.
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469782/rapidly-fatal-metastatic-cutaneous-angiosarcoma-initially-mimicking-a-furuncle-in-a-middle-aged-male
#20
Aaron S Cantor, Elizabeth Satter, Mark Douglas
Cutaneous angiosarcomas are rare but typically occur in three distinct clinical settings and are most commonly found on the scalp or face of elderly men. Positive prognostic factors include tumor size less than 5 cm, primary tumor location below the head, negative margins after excision, resectability, and younger age. Metastases drastically reduce survival and the most common metastatic site is lung. We present a 43-year-old man who had primary cutaneous angiosarcoma that initially mimicked a furuncle and eventuated in multiple metastases...
October 15, 2017: Dermatology Online Journal
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