Si-Min Sun, Bing-Wang Zhao, Yuan-Yuan Li, Hong-Yang Liu, Yuan-Hong Xu, Xue-Mei Yang, Jia-Ni Guo, Ying-Chun Ouyang, Chang-Jiang Weng, Yi-Chun Guan, Qing-Yuan Sun, Zhen-Bo Wang
The timely degradation of proteins that regulate the cell cycle is essential for oocyte maturation. Oocytes are equipped to degrade proteins via the ubiquitin-proteasome system. In meiosis, anaphase promoting complex/cyclosome (APC/C), an E3 ubiquitin-ligase, is responsible for the degradation of proteins. Ubiquitin-conjugating enzyme E2 S (UBE2S), an E2 ubiquitin-conjugating enzyme, delivers ubiquitin to APC/C. APC/C has been extensively studied, but the functions of UBE2S in oocyte maturation and mouse fertility are not clear...
March 15, 2024: Development