Jeraldine Weber, Thibault Legal, Alicia Perez Lezcano, Agata Gluszek-Kustusz, Calum Paterson, Susana Eibes, Marin Barisic, Owen R Davies, Julie P I Welburn
The outer corona plays an essential role at the onset of mitosis by expanding to maximize microtubule attachment to kinetochores.1 , 2 The low-density structure of the corona forms through the expansion of unattached kinetochores. It comprises the RZZ complex, the dynein adaptor Spindly, the plus-end directed microtubule motor centromere protein E (CENP-E), and the Mad1/Mad2 spindle-assembly checkpoint proteins.3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 CENP-E specifically associates with unattached kinetochores to facilitate chromosome congression,11 , 12 , 13 , 14 , 15 , 16 interacting with BubR1 at the kinetochore through its C-terminal region (2091-2358)...
February 8, 2024: Current Biology: CB