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https://www.readbyqxmd.com/read/28526957/cytomorphology-review-of-100-newly-diagnosed-lower-risk-mds-patients-in-the-european-leukemianet-mds-eumds-registry-reveals-a-high-inter-observer-concordance
#1
Louise de Swart, Alex Smith, Marius MacKenzie, Argiris Symeonidis, Judith Neukirchen, Dana Mikulenková, Teresa Vallespí, Gina Zini, Malgorzata Paszkowska-Kowalewska, Anton Kruger, Leonie Saft, Pierre Fenaux, David Bowen, Eva Hellström-Lindberg, Jaroslav Čermák, Reinhard Stauder, Aurelia Tatic, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Jackie Droste, Nicole Blijlevens, Theo de Witte, Ulrich Germing
The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists...
May 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28526744/combining-properties-of-different-classes-of-pi3k%C3%AE-inhibitors-to-understand-molecular-features-that-confer-selectivity
#2
Grace Q Gong, Jackie D Kendall, James Mj Dickson, Gordon W Rewcastle, Christina M Buchanan, William A Denny, Peter R Shepherd, Jack U Flanagan
Phosphoinositide 3-kinases (PI3K) are major regulators of many cellular functions, and hyperactivation of PI3K cell signalling pathways is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and our aim is to selectively inhibit this isoform, which may be more beneficial than concurrent inhibition of all Class I PI3Ks. We have used structure-guided design to merge high selectivity and high affinity characteristics found in existing compounds. Molecular docking including the prediction of water-mediated interactions, was used to model interactions between the ligands and the PI3Kα affinity pocket...
May 19, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28523967/comparative-assessment-of-dna-methylation-patterns-between-reduced-representation-bisulfite-sequencing-and-sequenom-epityper-methylation-analysis
#3
Aniruddha Chatterjee, Erin C Macaulay, Antonio Ahn, Jackie L Ludgate, Peter A Stockwell, Rob J Weeks, Matthew F Parry, Timothy J Foster, Ingrid M Knarston, Michael R Eccles, Ian M Morison
AIM: Validation of sequencing-based DNA methylation data is an important step for meaningful translation of findings. However, there has been limited assessment of different platforms to validate methylation data from next generation sequencing. METHODS: We performed a comparative methylation analysis between the genome-wide platform of reduced representation bisulfite sequencing with a targeted, Sequenom EpiTyper platform (four genes were analyzed in 15 cell lines covering 52 CpG sites)...
May 19, 2017: Epigenomics
https://www.readbyqxmd.com/read/28520745/high-handaxe-symmetry-at-the-beginning-of-the-european-acheulian-the-data-from-la-noira-france-in-context
#4
Radu Iovita, Inbal Tuvi-Arad, Marie-Hélène Moncel, Jackie Despriée, Pierre Voinchet, Jean-Jacques Bahain
In the last few decades, new discoveries have pushed the beginning of the biface-rich European Acheulian from 500 thousand years (ka) ago back to at least 700 ka, and possibly to 1 million years (Ma) ago. It remains, however, unclear to date if handaxes arrived in Europe as a fully developed technology or if they evolved locally from core-and-flake industries. This issue is also linked with another long-standing debate on the existence and behavioral, cognitive, and social meaning of a possibly chronological trend for increased handaxe symmetry throughout the Lower Paleolithic...
2017: PloS One
https://www.readbyqxmd.com/read/28516864/genomic-analysis-of-salmonella-enterica-serovar-typhimurium-dt160-associated-with-a-14-year-outbreak-new-zealand-1998-2012
#5
Samuel J Bloomfield, Jackie Benschop, Patrick J Biggs, Jonathan C Marshall, David T S Hayman, Philip E Carter, Anne C Midwinter, Alison E Mather, Nigel P French
During 1998-2012, an extended outbreak of Salmonella enterica serovar Typhimurium definitive type 160 (DT160) affected >3,000 humans and killed wild birds in New Zealand. However, the relationship between DT160 within these 2 host groups and the origin of the outbreak are unknown. Whole-genome sequencing was used to compare 109 Salmonella Typhimurium DT160 isolates from sources throughout New Zealand. We provide evidence that DT160 was introduced into New Zealand around 1997 and rapidly propagated throughout the country, becoming more genetically diverse over time...
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28513189/transcatheter-aortic-valve-implantation-the-transaortic-approach
#6
Simon Cy Chow, Gary Sh Cheung, Alex Pw Lee, Eugene B Wu, Jacky Yk Ho, Micky Wt Kwok, Peter Sy Yu, Innes Yp Wan, Malcolm J Underwood, Randolph Hl Wong
Background Transcatheter aortic valve implantation has been established as a safe and effective treatment option for patients at high or prohibitive surgical risk. However, some patients may not be suitable for the transfemoral approach due to severe iliofemoral disease or aneurysmal disease of the thoracoabdominal aorta. The aim of this case series was to evaluate the feasibility and clinical outcomes of the transaortic approach. Methods From May 2015 to June 2016, 5 patients (mean age 78.4 ± 3.9 years) with severe symptomatic aortic stenosis underwent transaortic transcatheter aortic valve implantation after a heart team discussion...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28511738/positive-psychology-outcome-measures-for-family-caregivers-of-people-living-with-dementia-a-systematic-review
#7
Jacki Stansfeld, Charlotte R Stoner, Jennifer Wenborn, Myrra Vernooij-Dassen, Esme Moniz-Cook, Martin Orrell
BACKGROUND: Family caregivers of people living with dementia can have both positive and negative experiences of caregiving. Despite this, existing outcome measures predominately focus on negative aspects of caregiving such as burden and depression. This review aimed to evaluate the development and psychometric properties of existing positive psychology measures for family caregivers of people living with dementia to determine their potential utility in research and practice. METHOD: A systematic review of positive psychology outcome measures for family caregivers of people with dementia was conducted...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28509730/american-college-of-critical-care-medicine-clinical-practice-parameters-for-hemodynamic-support-of-pediatric-and-neonatal-septic-shock
#8
Alan L Davis, Joseph A Carcillo, Rajesh K Aneja, Andreas J Deymann, John C Lin, Trung C Nguyen, Regina S Okhuysen-Cawley, Monica S Relvas, Ranna A Rozenfeld, Peter W Skippen, Bonnie J Stojadinovic, Eric A Williams, Tim S Yeh, Fran Balamuth, Joe Brierley, Allan R de Caen, Ira M Cheifetz, Karen Choong, Edward Conway, Timothy Cornell, Allan Doctor, Marc-Andre Dugas, Jonathan D Feldman, Julie C Fitzgerald, Heidi R Flori, James D Fortenberry, Ana Lia Graciano, Bruce M Greenwald, Mark W Hall, Yong Yun Han, Lynn J Hernan, Jose E Irazuzta, Elizabeth Iselin, Elise W van der Jagt, Howard E Jeffries, Saraswati Kache, Chhavi Katyal, Niranjan Tex Kissoon, Alexander A Kon, Martha C Kutko, Graeme MacLaren, Timothy Maul, Renuka Mehta, Fola Odetola, Kristine Parbuoni, Raina Paul, Mark J Peters, Suchitra Ranjit, Karin E Reuter-Rice, Eduardo J Schnitzler, Halden F Scott, Adalberto Torres, Jacki Weingarten-Abrams, Scott L Weiss, Jerry J Zimmerman, Aaron L Zuckerberg
OBJECTIVES: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock." DESIGN: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014)...
June 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28508237/development-of-a-unifying-target-and-consensus-indicators-for-global-surgical-systems-strengthening-proposed-by-the-global-alliance-for-surgery-obstetric-trauma-and-anaesthesia-care-the-g4-alliance
#9
REVIEW
Adil Haider, John W Scott, Colin D Gause, Mira Meheš, Grace Hsiung, Albulena Prelvukaj, Dana Yanocha, Lauren M Baumann, Faheem Ahmed, Na'eem Ahmed, Sara Anderson, Herve Angate, Lisa Arfaa, Horacio Asbun, Tigistu Ashengo, Kisembo Asuman, Ruben Ayala, Stephen Bickler, Saul Billingsley, Peter Bird, Matthijs Botman, Marilyn Butler, Jo Buyske, Angelo Capozzi, Kathleen Casey, Charles Clayton, James Cobey, Michael Cotton, Dan Decklebaum, Milliard Derbew, Catherine deVries, Jeanne Dillner, Max Downham, Natalie Draisin, David Echinard, Sohier Elneil, Ahmed ElSayed, Abigail Estelle, Allen Finley, Erica Frenkel, Philip K Frykman, Florin Gheorghe, Julian Gore-Booth, Richard Henker, Jaymie Henry, Orion Henry, Laura Hoemeke, David Hoffman, Iko Ibanga, Eric V Jackson, Pankaj Jani, Walter Johnson, Andrew Jones, Zeina Kassem, Asuman Kisembo, Abbey Kocan, Sanjay Krishnaswami, Robert Lane, Asad Latif, Barbara Levy, Dimitrios Linos, Peter Linz, Louis A Listwa, Declan Magee, Emmanuel Makasa, Michael L Marin, Claude Martin, Kelly McQueen, Jaime Morgan, Richard Moser, Robert Neighbor, William M Novick, Stephen Ogendo, Akinyinka Omigbodun, Bisola Onajin-Obembe, Neil Parsan, Beverly K Philip, Raymond Price, Shahnawaz Rasheed, Marjorie Ratel, Cheri Reynolds, Steven M Roser, Jackie Rowles, Lubna Samad, John Sampson, Harshadkumar Sanghvi, Marchelle L Sellers, David Sigalet, Bruce C Steffes, Erin Stieber, Mamta Swaroop, John Tarpley, Asha Varghese, Julie Varughese, Richard Wagner, Benjamin Warf, Neil Wetzig, Susan Williamson, Joshua Wood, Anne Zeidan, Lewis Zirkle, Brendan Allen, Fizan Abdullah
After decades on the margins of primary health care, surgical and anaesthesia care is gaining increasing priority within the global development arena. The 2015 publications of the Disease Control Priorities third edition on Essential Surgery and the Lancet Commission on Global Surgery created a compelling evidenced-based argument for the fundamental role of surgery and anaesthesia within cost-effective health systems strengthening global strategy. The launch of the Global Alliance for Surgical, Obstetric, Trauma, and Anaesthesia Care in 2015 has further coordinated efforts to build priority for surgical care and anaesthesia...
May 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28504060/responding-to-the-support-needs-of-frontline-public-health-nurses-who-work-with-vulnerable-families-and-children-a-qualitative-study
#10
Jackie Austin, Stephanie Holt
BACKGROUND: This paper reports on a research study to inform the development of a specialist role designed to lead and support front line public health nurses (PHNs) working with vulnerable families and at risk children in Ireland. PHNs in Ireland provide a programme of intervention that promotes optimum health and wellbeing for all children in their early years under the governance of the Health Service Executive. This universal access places the PHN as a central participant in the safeguarding of young children, particularly those working in disadvantaged communities where frequent exposure to difficult situations is a common factor...
May 13, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28501369/validation-study-of-the-screenivf-an-instrument-to-screen-women-or-men-on-risk-for-emotional-maladjustment-before-the-start-of-a-fertility-treatment
#11
Henrietta D L Ockhuijsen, Maarten van Smeden, Agnes van den Hoogen, Jacky Boivin
OBJECTIVE: To examine construct and criterion validity of the Dutch SCREENIVF among women and men undergoing a fertility treatment. DESIGN: A prospective longitudinal study nested in a randomized controlled trial. SETTING: University hospital. PATIENT(S): Couples, 468 women and 383 men, undergoing an IVF/intracytoplasmic sperm injection (ICSI) treatment in a fertility clinic, completed the SCREENIVF. MAIN OUTCOME MEASURE(S): Construct and criteria validity of the SCREENIVF...
May 10, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28500678/bgg492-as-an-adjunctive-treatment-in-patients-with-partial-onset-seizures-a-12-week-randomized-double-blind-placebo-controlled-phase-ii-dose-titration-study-with-an-open-label-extension
#12
Christian E Elger, Seung Bong Hong, Christian Brandt, Linda Mancione, Jackie Han, Christine Strohmaier
OBJECTIVES: To evaluate dose-response relationship of BGG492 as add-on therapy to 1-3 antiepileptic drugs in patients with partial-onset seizures and to investigate safety and tolerability of BGG492. METHODS: This was a 12-week, randomized, double-blind, placebo-controlled, phase II dose-titration study (core study) with a 30-week, flexible-dose, open-label extension. In the core study, patients were randomized (1:2) to placebo or BGG492 100 mg t.i.d. in cohort 1, and in cohort 2 patients were randomized (1:4) to placebo or BGG492 150 mg t...
May 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28499689/an-89-year-old-man-hanging-in-a-remote-location
#13
Peter V R Tilney, Jackie Turcotte, George Stuart
No abstract text is available yet for this article.
May 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28497097/a-randomized-controlled-pilot-study-of-educational-techniques-in-teaching-basic-arthroscopic-skills-in-a-low-income-country
#14
Abhiram R Bhashyam, Catherine Logan, Heather J Roberts, Rameez A Qudsi, Jacky Fils, George S M Dyer
BACKGROUND: Little is known about how to introduce complex technologies like arthroscopy into low-income countries. Thus, we compared low- versus high-resource intensive methods of teaching basic arthroscopic skills in a randomized controlled trial in Haiti. METHODS: Forty-eight Haitian orthopaedic surgeons and residents attending an orthopaedic conference in Haiti were block randomized to receive instruction through a composite video (Control) or a composite video plus hands-on teaching with an expert visiting surgeon (Intervention)...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28495527/facilitating-state-wide-collaboration-around-family-planning-care-in-the-context-of-zika
#15
Christine Dehlendorf, Loretta Gavin, Jacki Witt, Susan Moskosky
INTRODUCTION: Family planning providers have an important role to play in the response to the public health challenge posed by Zika. In the United States, there are high rates of unintended pregnancy, especially in states most at risk for mosquito-borne transmission of the Zika virus. This paper describes efforts by eight of these states (Arizona, California, Florida, Georgia, Louisiana, Mississippi, South Carolina, and Texas) to build capacity for quality family planning care in the context of Zika...
May 8, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28494655/significant-locus-and-metabolic-genetic-correlations-revealed-in-genome-wide-association-study-of-anorexia-nervosa
#16
Laramie Duncan, Zeynep Yilmaz, Helena Gaspar, Raymond Walters, Jackie Goldstein, Verneri Anttila, Brendan Bulik-Sullivan, Stephan Ripke, Laura Thornton, Anke Hinney, Mark Daly, Patrick F Sullivan, Eleftheria Zeggini, Gerome Breen, Cynthia M Bulik
OBJECTIVE: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. METHOD: Following uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts...
May 12, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28490349/cognitive-behavioural-therapy-for-the-management-of-inflammatory-bowel-disease-fatigue-with-a-nested-qualitative-element-study-protocol-for-a-randomised-controlled-trial
#17
Micol Artom, Wladyslawa Czuber-Dochan, Jackie Sturt, Christine Norton
BACKGROUND: Fatigue is one of the most prevalent and burdensome symptoms for patients with inflammatory bowel disease (IBD). Although fatigue increases during periods of inflammation, for some patients it persists when disease is in remission. Compared to other long-term conditions where fatigue has been extensively researched, optimal management of fatigue in patients with IBD is unknown and fatigue has rarely been the primary outcome in intervention studies. To date, interventions for the management of IBD-fatigue are sparse, have short-term effects and have not been implemented within the existing health system...
May 11, 2017: Trials
https://www.readbyqxmd.com/read/28487353/the-chromatin-remodelling-factor-atrx-suppresses-r-loops-in-transcribed-telomeric-repeats
#18
Diu Tt Nguyen, Hsiao Phin J Voon, Barbara Xella, Caroline Scott, David Clynes, Christian Babbs, Helena Ayyub, Jon Kerry, Jacqueline A Sharpe, Jackie A Sloane-Stanley, Sue Butler, Chris A Fisher, Nicki E Gray, Thomas Jenuwein, Douglas R Higgs, Richard J Gibbons
ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG)n ATRX mutations are found in nearly all tumours that maintain their telomeres via the alternative lengthening of telomere (ALT) pathway, and ATRX is known to suppress this pathway. Here, we show that recruitment of ATRX to telomeric repeats depends on repeat number, orientation and, critically, on repeat transcription. Importantly, the transcribed telomeric repeats form RNA-DNA hybrids (R-loops) whose abundance correlates with the recruitment of ATRX Here, we show loss of ATRX is also associated with increased R-loop formation...
May 9, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28486033/predictors-of-consent-in-a-randomized-field-study-in-child-welfare
#19
Tom McDonald, Jackie Bhattarai, Becci Akin
PURPOSE: Randomized controlled trials (RCTs) are often viewed as the "gold standard" for proving the efficacy and effectiveness of new interventions. However, some are skeptical of the generalizability of the findings that RCTs produce. The characteristics of those willing to participate in research studies have the potential to affect the generalizability of its findings. This study examined factors that could influence consent among families recruited to participate in a randomized field trial in a real-world child welfare setting...
May 9, 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/28482252/positive-youth-development-practices-and-better-outcomes-for-high-risk-youth
#20
Jackie Sanders, Robyn Munford, Linda Liebenberg
This paper reports on the findings from a New Zealand longitudinal study of outcomes for a group of high risk, service-using youth (13-21 years, n=495). Consistent use of positive youth development practices (PYD) (rather than the total number of services used) predicted better outcomes. Patterns of risk and resilience endured over time. Individual risks undermined outcomes while resilience had a significant positive impact on outcomes. Contextual risks predicted increases in individual risks, but service delivery that adopted PYD practices contributed to reductions in levels of contextual risks over time...
May 5, 2017: Child Abuse & Neglect
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