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https://www.readbyqxmd.com/read/29331743/preliminary-investigation-of-human-exhaled-breath-for-tuberculosis-diagnosis-by-multidimensional-gas-chromatography-time-of-flight-mass-spectrometry-and-machine-learning
#1
Marco Beccaria, Theodore R Mellors, Jacky S Petion, Christiaan A Rees, Mavra Nasir, Hannah K Systrom, Jean W Sairistil, Marc-Antoine Jean-Juste, Vanessa Rivera, Kerline Lavoile, Patrice Severe, Jean W Pape, Peter F Wright, Jane E Hill
Tuberculosis (TB) remains a global public health malady that claims almost 1.8 million lives annually. Diagnosis of TB represents perhaps one of the most challenging aspects of tuberculosis control. Gold standards for diagnosis of active TB (culture and nucleic acid amplification) are sputum-dependent, however, in up to a third of TB cases, an adequate biological sputum sample is not readily available. The analysis of exhaled breath, as an alternative to sputum-dependent tests, has the potential to provide a simple, fast, and non-invasive, and ready-available diagnostic service that could positively change TB detection...
January 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331463/discriminating-aging-and-protein-to-fat-ratio-in-cheddar-cheese-using-sensory-analysis-and-a-potentiometric-electronic-tongue
#2
Jackie B Lipkowitz, Carolyn F Ross, Charles Diako, Denise M Smith
The objectives of this study were to evaluate the flavor and taste attributes of full-fat Cheddar cheeses with different protein-to-fat ratios (PFR) over aging time using a descriptive sensory analysis panel and a consumer panel, and to correlate these attributes with instrumental parameters obtained by the potentiometric electronic tongue. Three Cheddar cheese formulations (PFR of 0.74, 0.85, and 1.01) were produced in triplicate and composition was verified. Cheese was aged at 7.2°C and evaluated at 2, 5, 8, 10, 11, and 12 mo by a trained panel (n = 10) for 8 flavor and 5 taste attributes and using an electronic tongue for 7 nonvolatile taste attributes...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29329925/phenotypic-and-molecular-characterisation-of-a-serum-free-miniature-erythroid-differentiation-system-suitable-for-high-throughput-screening-and-single-cell-assays
#3
Sachith Mettananda, Kevin Clark, Chris A Fisher, Jackie A Sloane-Stanley, Richard J Gibbons, Douglas R Higgs
In vitro erythroid differentiation systems are used to study the mechanisms underlying normal and abnormal erythropoiesis and to test the effects of various extracellular factors on erythropoiesis. The use of serum or conditioned medium in liquid cultures, and seeding cultures with heterogeneous peripheral blood mononuclear cells confound the reproducibility of these systems. Newer erythroid differentiation culture systems have overcome some of these limitations by using a fully defined, serum-free, medium and initiating cultures using purified CD34+ cells...
January 9, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29327409/cultural-aspects-of-pain-a-study-of-indian-asian-women-in-the-uk
#4
Stephanie Holt, Jackie Waterfield
OBJECTIVES: Culture and ethnicity are acknowledged as important factors in the context of the biopsychosocial model. They may contribute to explaining the experience of pain, therapeutic encounters within healthcare, and the strategies that individuals use to cope with pain. The present study explored these issues in a sample of Indian Asian women in the UK. METHODS: Based on a phenomenological approach, 17 women participated in five semi-structured group interviews...
January 12, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29326537/total-ossicular-replacement-prosthesis-a-new-fat-interposition-technique
#5
Issam Saliba, Valérie Sabbah, Jackie Bibeau Poirier
Objective: To compare audiometric results between the standard total ossicular replacement prosthesis (TORP-S) and a new fat interposition total ossicular replacement prosthesis (TORP-F) in pediatric and adult patients and to assess the complication and the undesirable outcome. Study design: This is a retrospective study. Methods: This study included 104 patients who had undergone titanium implants with TORP-F and 54 patients who had undergone the procedure with TORP-S between 2008 and 2013 in our tertiary care centers...
2018: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29326199/genome-sequences-of-four-cluster-p-mycobacteriophages
#6
Erin L Doyle, Christy L Fillman, Nathan S Reyna, Deborah M Tobiason, Daniel E Westholm, Jonathan L Askins, Brittany P Backus, Ashlynn C Baker, Harrison S Ballard, Paul J Bisesi, Logan Bond, Deanna Byrnes, Hannah Carlstedt, Kinnon S Dodson, Megan J Fallert, Kyla J Foster, Daniel N Games, Tristan R Grams, Nancy A Guild, Autumn Hurd, Nicholas Iwata, Cassidy R Kepler, Lucinda R Krenzke, Kelly Luekens, Jackie Lewis, Cali McEntee, Justin C McGee, Noah Nalley, Ruth C Plymale, Jade Prochaska, Reid G Rogers, Jessica B Schipper, Kelsey Snyder, Kali Uhrich, Chelsey D Vermillion, Sarah K Vickers, Meredyth D Wenta, Tyler Z Yates, Chas F Young, Ty H Stoner, Welkin H Pope, Deborah Jacobs-Sera, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Graham F Hatfull
Four bacteriophages infecting Mycobacterium smegmatis mc2155 (three belonging to subcluster P1 and one belonging to subcluster P2) were isolated from soil and sequenced. All four phages are similar in the left arm of their genomes, but the P2 phage differs in the right arm. All four genomes contain features of temperate phages.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325117/blood-rna-signatures-prospectively-discriminate-controllers-from-progressors-early-after-low-dose-m-tuberculosis-infection-of-cynomolgus-macaques
#7
Ethan G Thompson, Smitha Shankar, Hannah P Gideon, Jackie Braun, Joe Valvo, Jason Skinner, Alan Aderem, JoAnne L Flynn, Philana Ling Lin, Daniel E Zak
The cynomolgus macaque model of low-dose Mycobacterium tuberculosis (Mtb) infection recapitulates clinical aspects of human TB pathology but it is unknown whether the two systems are sufficiently similar that host-based signatures of TB will be predictive across species. By blind prediction, we demonstrate that a subset of genes comprising a human signature for TB risk is simultaneously predictive in humans and macaques and prospectively discriminates progressor from controller animals 3-6 weeks after infection...
January 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29321557/haptic-shape-discrimination-and-interhemispheric-communication
#8
Catherine J Dowell, J Farley Norman, Jackie R Moment, Lindsey M Shain, Hideko F Norman, Flip Phillips, Astrid M L Kappers
In three experiments participants haptically discriminated object shape using unimanual (single hand explored two objects) and bimanual exploration (both hands were used, but each hand, left or right, explored a separate object). Such haptic exploration (one versus two hands) requires somatosensory processing in either only one or both cerebral hemispheres; previous studies related to the perception of shape/curvature found superior performance for unimanual exploration, indicating that shape comparison is more effective when only one hemisphere is utilized...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315591/suppression-of-a-single-bahd-gene-in-setaria-viridis-causes-large-stable-decreases-in-cell-wall-feruloylation-and-increases-biomass-digestibility
#9
Wagner R de Souza, Polyana K Martins, Jackie Freeman, Till K Pellny, Louise V Michaelson, Bruno L Sampaio, Felipe Vinecky, Ana P Ribeiro, Barbara A D B da Cunha, Adilson K Kobayashi, Patricia A de Oliveira, Raquel B Campanha, Thályta F Pacheco, Danielly C I Martarello, Rogério Marchiosi, Osvaldo Ferrarese-Filho, Wanderley D Dos Santos, Robson Tramontina, Fabio M Squina, Danilo C Centeno, Marília Gaspar, Marcia R Braga, Marco A S Tiné, John Ralph, Rowan A C Mitchell, Hugo B C Molinari
Feruloylation of arabinoxylan (AX) in grass cell walls is a key determinant of recalcitrance to enzyme attack, making it a target for improvement of grass crops, and of interest in grass evolution. Definitive evidence on the genes responsible is lacking so we studied a candidate gene that we identified within the BAHD acyl-CoA transferase family. We used RNA interference (RNAi) silencing of orthologs in the model grasses Setaria viridis (SvBAHD01) and Brachypodium distachyon (BdBAHD01) and determined effects on AX feruloylation...
January 8, 2018: New Phytologist
https://www.readbyqxmd.com/read/29314326/stable-light-emitting-diodes-using-phase-pure-ruddlesden-popper-layered-perovskites
#10
Hsinhan Tsai, Wanyi Nie, Jean-Christophe Blancon, Constantinos C Stoumpos, Chan Myae Myae Soe, Jinkyoung Yoo, Jared Crochet, Sergei Tretiak, Jacky Even, Aditya Sadhanala, Giovanni Azzellino, Roberto Brenes, Pulickel M Ajayan, Vladimir Bulović, Samuel D Stranks, Richard H Friend, Mercouri G Kanatzidis, Aditya D Mohite
State-of-the-art light-emitting diodes (LEDs) are made from high-purity alloys of III-V semiconductors, but high fabrication cost has limited their widespread use for large area solid-state lighting. Here, efficient and stable LEDs processed from solution with tunable color enabled by using phase-pure 2D Ruddlesden-Popper (RP) halide perovskites with a formula (CH3 (CH2 )3 NH3 )2 (CH3 NH3 )n-1 Pbn I3n+1 are reported. By using vertically oriented thin films that facilitate efficient charge injection and transport, efficient electroluminescence with a radiance of 35 W Sr-1 cm-2 at 744 nm with an ultralow turn-on voltage of 1 V is obtained...
January 3, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29305339/digital-clinical-communication-for-families-and-caregivers-of-children-or-young-people-with-short-or-long-term-conditions-rapid-review
#11
REVIEW
Xavier Armoiry, Jackie Sturt, Emma Elizabeth Phelps, Clare-Louise Walker, Rachel Court, Frances Taggart, Paul Sutcliffe, Frances Griffiths, Helen Atherton
BACKGROUND: The communication relationship between parents of children or young people with health conditions and health professionals is an important part of treatment, but it is unclear how far the use of digital clinical communication tools may affect this relationship. OBJECTIVE: The objective of our study was to describe, assess the feasibility of, and explore the impact of digital clinical communication between families or caregivers and health professionals...
January 5, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29304943/using-a-discrete-choice-experiment-involving-cost-to-value-a-classification-system-measuring-the-quality-of-life-impact-of-self-management-for-diabetes
#12
Donna Rowen, Katherine Stevens, Alexander Labeit, Jackie Elliott, Brendan Mulhern, Jill Carlton, Hasan Basarir, Julie Ratcliffe, John Brazier
OBJECTIVES: To describe the use of a novel approach in health valuation of a discrete-choice experiment (DCE) including a cost attribute to value a recently developed classification system for measuring the quality-of-life impact (both health and treatment experience) of self-management for diabetes. METHODS: A large online survey was conducted using DCE with cost on UK respondents from the general population (n = 1497) and individuals with diabetes (n = 405). The data were modeled using a conditional logit model with robust standard errors...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29301143/prostate-specific-antigen-velocity-in-a-prospective-prostate-cancer-screening-study-of-men-with-genetic-predisposition
#13
Christos Mikropoulos, Christina G Hutten Selkirk, Sibel Saya, Elizabeth Bancroft, Emily Vertosick, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Alexander Dias, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Karol Axcrona, Kate Richardson, Diana Eccles, Thomas Jensen, Palle J Osther, Christi J van Asperen, Hans Vasen, Lambertus A Kiemeney, Janneke Ringelberg, Cezary Cybulski, Dominika Wokolorczyk, Rachel Hart, Wayne Glover, Jimmy Lam, Louise Taylor, Monica Salinas, Lidia Feliubadaló, Rogier Oldenburg, Ruben Cremers, Gerald Verhaegh, Wendy A van Zelst-Stams, Jan C Oosterwijk, Jackie Cook, Derek J Rosario, Saundra S Buys, Tom Conner, Susan Domchek, Jacquelyn Powers, Margreet Gem Ausems, Manuel R Teixeira, Sofia Maia, Louise Izatt, Rita Schmutzler, Kerstin Rhiem, William D Foulkes, Talia Boshari, Rosemarie Davidson, Marielle Ruijs, Apollonia Tjm Helderman-van den Enden, Lesley Andrews, Lisa Walker, Katie Snape, Alex Henderson, Irene Jobson, Geoffrey J Lindeman, Annelie Liljegren, Marion Harris, Muriel A Adank, Judy Kirk, Amy Taylor, Rachel Susman, Rakefet Chen-Shtoyerman, Nicholas Pachter, Allan Spigelman, Lucy Side, Janez Zgajnar, Josefina Mora, Carole Brewer, Neus Gadea, Angela F Brady, David Gallagher, Theo van Os, Alan Donaldson, Vigdis Stefansdottir, Julian Barwell, Paul A James, Declan Murphy, Eitan Friedman, Nicola Nicolai, Lynn Greenhalgh, Elias Obeid, Vedang Murthy, Lucia Copakova, John McGrath, Soo-Hwang Teo, Sara Strom, Karin Kast, Daniel A Leongamornlert, Anthony Chamberlain, Jenny Pope, Anna C Newlin, Neil Aaronson, Audrey Ardern-Jones, Chris Bangma, Elena Castro, David Dearnaley, Jorunn Eyfjord, Alison Falconer, Christopher S Foster, Henrik Gronberg, Freddie C Hamdy, Oskar Johannsson, Vincent Khoo, Jan Lubinski, Eli Marie Grindedal, Joanne McKinley, Kylie Shackleton, Anita V Mitra, Clare Moynihan, Gad Rennert, Mohnish Suri, Karen Tricker, Sue Moss, Zsofia Kote-Jarai, Andrew Vickers, Hans Lilja, Brian T Helfand, Rosalind A Eeles
BACKGROUND: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values...
January 4, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29300858/evidence-supporting-a-role-for-constitutive-ghrelin-receptor-signaling-in-fasting-induced-hyperphagia-in-male-mice
#14
Gimena Fernandez, Agustina Cabral, María F Andreoli, Alexandra Labarthe, Céline M'Kadmi, Jorge G Ramos, Jacky Marie, Jean-Alain Fehrentz, Jacques Epelbaum, Virginie Tolle, Mario Perello
Ghrelin is a potent orexigenic peptide hormone that acts through the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor highly expressed in the hypothalamus. In vitro studies have shown GHSR displays a high constitutive activity, whose physiological relevance is uncertain. Since GHSR gene expression in the hypothalamus is known to increase in fasting conditions, we tested the hypothesis that constitutive GHSR activity at hypothalamic level drives the fasting-induced hyperphagia. We found refed wild-type (WT) mice displayed a robust hyperphagia that continued for 5 days after refeeding and changed their food intake daily pattern...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29299833/engagement-of-canadian-patients-with-rare-diseases-and-their-families-in-the-lifecycle-of-therapy-a-qualitative-study
#15
Andrea Young, Devidas Menon, Jackie Street, Walla Al-Hertani, Tania Stafinski
INTRODUCTION: Patient involvement is increasingly recognized as critical to the development, introduction and use (i.e. the lifecycle) of new and effective therapies, particularly those for rare diseases, where natural histories and the impact on patients and families are less well-understood than for common diseases. However, little is known about how patients and families would like to be involved during the lifecycle. OBJECTIVE: The aim of this study was to explore ways in which Canadian patients with rare diseases and their families would like to be involved in the lifecycle of therapies and identify their priorities for involvement...
January 3, 2018: Patient
https://www.readbyqxmd.com/read/29295891/a-peptidylic-inhibitor-for-neutralizing-expanded-cag-rna-induced-nucleolar-stress-in-polyglutamine-diseases
#16
Qian Zhang, Zhefan Stephen Chen, Ying An, Haizhen Liu, Yonghui Hou, Wen Li, Kwok-Fai Lau, Alex Koon, Jacky Ngo, Edwin Chan
Polyglutamine (polyQ) diseases are a set of progressive neurodegenerative disorders ascribed by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) leads to impediment of pre-ribosomal RNA (pre-rRNA) transcription, and eventually triggers nucleolar stress-induced apoptosis in polyQ diseases. Here, we report a 21-amino acid peptide, named beta-structured inhibitor for neurodegenerative disease (BIND), effectively suppresses expanded CAG RNA toxicity...
January 2, 2018: RNA
https://www.readbyqxmd.com/read/29288740/rationale-design-and-pilot-feasibility-results-of-a-smartphone-assisted-mindfulness-based-intervention-for-smokers-with-mood-disorders-project-msmart-mind
#17
Haruka Minami, Hannah R Brinkman, Shadi Nahvi, Julia H Arnsten, Monica Rivera-Mindt, David W Wetter, Erika Litvin Bloom, Lawrence H Price, Carlos Vieira, Remington Donnelly, Lauren M McClain, Katherine A Kennedy, Erica D'Aquila, M Fine, Danielle E McCarthy, J Graham Thomas, Jacki Hecht, Richard A Brown
BACKGROUND: Although individuals with psychiatric disorders are disproportionately affected by cigarette smoking, few outpatient mental health treatment facilities offer smoking cessation services. In this paper, we describe the development of a smartphone-assisted mindfulness smoking cessation intervention with contingency management (SMI-CM), as well as the design and methods of an ongoing pilot randomized controlled trial (RCT) targeting smokers receiving outpatient psychiatric treatment...
December 27, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29283493/the-checklist-of-unit-behaviors-cub-validation-within-a-canadian-outpatient-day-hospital-program
#18
Marlene Taube-Schiff, Christo El Morr, Alyssa Counsell, Aiden Mehak, Jackie Gollan
INTRODUCTION: We evaluated the Checklist of Unit Behaviors (CUB) questionnaire in a novel mental health setting: a day hospital within a large acute care general hospital. The CUB measures two factors, Avoidance or Approach, of the patients' engagement with the treatment milieu within the previous 24 hours. AIM: A Confirmatory Factor Analysis (CFA) was conducted to validate the CUB's original two factor structure in an outpatient day program. METHOD: Psychiatric outpatients (N=163) completed the CUB daily while participating in a day hospital program in Toronto, Canada...
December 28, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29278986/reach-and-effectiveness-of-the-heartbeat-connections-telemedicine-pilot-program
#19
Gretchen A Benson, Abbey Sidebottom, Arthur Sillah, Jackie L Boucher, Michael D Miedema, Thomas Knickelbine, Jeffrey J VanWormer
Introduction Innovative care delivery programs that support primary care providers are needed to reduce the burden of cardiovascular disease (CVD). HeartBeat Connections (HBC) is a primary prevention telemedicine program utilizing registered dietitian nutritionists (RDNs) and registered nurses (RNs) to deliver health coaching and medication therapy protocols for dyslipidaemia and hypertension among patients at high risk for developing CVD. Methods This retrospective cohort study documents the reach and six-month effectiveness of the HBC program for improving CVD risk factors...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29275880/long-term-effects-of-statins-blood-pressure-lowering-and-both-on-erectile-function-in-persons-at-intermediate-risk-for-cardiovascular-disease-a-substudy-of-the-heart-outcomes-prevention-evaluation-3-hope-3-randomized-controlled-trial
#20
Philip Joseph, Eva Lonn, Jackie Bosch, Patricio Lopez, Jun Zhu, Matyas Keltai, Anthony Dans, Christopher Reid, Kamlesh Khunti, William Toff, Leopoldo Piegas, Jae-Hyung Kim, Balakumar Swaminathan, Michael Bohm, Salim Yusuf
BACKGROUND: It is unclear whether modifying cholesterol, blood pressure, or both affect erectile dysfunction. Also, there are concerns that erectile dysfunction is worsened by common medications used to treat these risk factors. In this study, we evaluated the effect of: (1) cholesterol-lowering with a statin; (2) pharmacologic blood pressure reduction; and (3) their combination, on erectile function. METHODS: A priori, this was a secondary analysis of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) randomized controlled trial...
January 2018: Canadian Journal of Cardiology
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