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https://www.readbyqxmd.com/read/29788981/safety-of-pazopanib-and-sunitinib-in-treatment-naive-patients-with-metastatic-renal-cell-carcinoma-asian-versus-non-asian-subgroup-analysis-of-the-comparz-trial
#1
Jun Guo, Jie Jin, Mototsugu Oya, Hirotsugu Uemura, Shunji Takahashi, Katsunori Tatsugami, Sun Young Rha, Jae-Lyun Lee, Jinsoo Chung, Ho Yeong Lim, Hsi Chin Wu, Yen Hwa Chang, Arun Azad, Ian D Davis, Marlene J Carrasco-Alfonso, Bhupinder Nanua, Jackie Han, Qasim Ahmad, Robert Motzer
BACKGROUND: The international, phase 3 COMPARZ study demonstrated that pazopanib and sunitinib have comparable efficacy as first-line therapy in patients with advanced renal cell carcinoma, but that safety and quality-of-life profiles favor pazopanib. Our report analyzed pazopanib and sunitinib safety in Asian and non-Asian subpopulations. METHODS: Patients were randomized 1:1 to receive pazopanib 800 mg once daily (continuous dosing) or sunitinib 50 mg once daily in 6-week cycles (4 weeks on, 2 weeks off)...
May 22, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29788323/development-and-psychometric-properties-of-the-inflammatory-bowel-disease-distress-scale-ibd-ds-a-new-tool-to-measure-disease-specific-distress
#2
Lesley Dibley, Wladyslawa Czuber-Dochan, Sue Woodward, Tiffany Wade, Paul Bassett, Jackie Sturt, Christine Norton
Background: Inflammatory bowel disease (IBD) imposes a heavy psychosocial burden, with many patients reporting anxiety, depression, and distress. In diseases such as diabetes, disease-specific distress is associated with concordance with treatments and disease control. IBD distress, distinct from anxiety and depression, is evident in people with IBD. We aimed to develop a questionnaire for assessing IBD-specific distress, validate this against a gold standard distress measure for diabetes, and demonstrate the difference between anxiety, depression, and distress...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29786453/cross-cultural-adaptation-and-psychometric-evaluation-of-the-singapore-version-of-the-chedoke-arm-and-hand-activity
#3
Silvana X Choo, Jackie Bosch, Julie Richardson, Paul Stratford, Jocelyn E Harris
PURPOSE: To develop a Singapore version of the Chedoke Arm and Hand Activity Inventory (CAHAI) and to estimate the construct validity and inter-rater reliability. MATERIALS AND METHODS: The Translation and Cross-Cultural Adaptation of Objectively Assessed Outcome measure procedure was used to systematically adapt the CAHAI. We recruited 56 adults admitted to an inpatient stroke facility to evaluate the psychometric properties of the Singapore version of the CAHAI...
May 22, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29785712/there-is-moderate-evidence-that-the-process-of-service-delivery-for-assistive-technology-relates-to-client-satisfaction-with-the-technology
#4
Jacki Liddle, Zoe du Cann
No abstract text is available yet for this article.
May 21, 2018: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29780499/rational-design-of-a-water-soluble-nir-aiegen-and-its-application-in-ultrafast-wash-free-cellular-imaging-and-photodynamic-cancer-cell-ablation
#5
Dong Wang, Huifang Su, Ryan T K Kwok, Xianglong Hu, Hang Zou, Qianxin Luo, Michelle M S Lee, Wenhan Xu, Jacky W Y Lam, Ben Zhong Tang
The synthesis of water-soluble near-infrared (NIR)-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics and theranostic functions is highly desirable but remains challenging. In this work, we designed and readily prepared for the first time such a molecule with AIE features, good water-solubility and intense emission in the NIR region. This AIE luminogen (AIEgen) is able to specifically "light up" the cell membrane without the involvement of a washing procedure. Interestingly, the staining process can be performed by simply shaking the culture with cells at room temperature for only a few seconds after the addition of the AIEgen, indicating an ultrafast and easy-to-operate staining protocol...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779895/identification-and-single-cell-functional-characterization-of-an-endodermally-biased-pluripotent-substate-in-human-embryonic-stem-cells
#6
Thomas F Allison, Andrew J H Smith, Konstantinos Anastassiadis, Jackie Sloane-Stanley, Veronica Biga, Dylan Stavish, James Hackland, Shan Sabri, Justin Langerman, Mark Jones, Kathrin Plath, Daniel Coca, Ivana Barbaric, Paul Gokhale, Peter W Andrews
Human embryonic stem cells (hESCs) display substantial heterogeneity in gene expression, implying the existence of discrete substates within the stem cell compartment. To determine whether these substates impact fate decisions of hESCs we used a GFP reporter line to investigate the properties of fractions of putative undifferentiated cells defined by their differential expression of the endoderm transcription factor, GATA6, together with the hESC surface marker, SSEA3. By single-cell cloning, we confirmed that substates characterized by expression of GATA6 and SSEA3 include pluripotent stem cells capable of long-term self-renewal...
May 9, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29778829/a-qualitative-investigation-of-the-attitudes-and-beliefs-about-physical-activity-and-post-traumatic-osteoarthritis-in-young-adults-3-10-years-after-an-intra-articular-knee-injury
#7
Allison M Ezzat, Mariana Brussoni, Jackie L Whittaker, Carolyn A Emery
OBJECTIVE: To understand the influence of the injury experience on current attitudes and beliefs about physical activity (PA) and the development of post-traumatic osteoarthritis (PTOA) in youth and young adults 3-10 years after a sport-related knee injury. DESIGN: Qualitative study. SETTING: University Sports Medical/Research Center. PARTICIPANTS: 20 young adults 3-10 years subsequent to intra-articular knee injury...
May 4, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29776906/blood-induced-bone-loss-in-murine-hemophilic-arthropathy-is-prevented-by-blocking-the-irhom2-adam17-tnf%C3%AE-pathway
#8
Coline Haxaire, Narine Hakobyan, Tania Pannellini, Camila Carballo, David McIlwain, Tak W Mak, Scott Rodeo, Suchitra Acharya, Daniel Li, Jackie Szymonifka, Xiangqian Song, Sébastien Monette, Alok Srivastava, Jane E Salmon, Carl P Blobel
Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major manifestation of the bleeding disorder Hemophilia A. HA typically begins with hemophilic synovitis (HS) that resembles inflammatory arthritides such as rheumatoid arthritis (RA) and frequently results in bone loss in patients. A major cause of RA is inappropriate release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα) by the TNFα convertase (TACE, also referred to as ADAM17) and its regulator, iRhom2...
May 18, 2018: Blood
https://www.readbyqxmd.com/read/29776778/three-years-post-affordable-care-act-sexually-transmitted-disease-clinics-remain-critical-among-vulnerable-populations
#9
Nicky J Mehtani, Christina M Schumacher, Luke E Johnsen, Adena Greenbaum, C Patrick Chaulk, Khalil G Ghanem, Jacky M Jennings, Kathleen R Page
INTRODUCTION: The purpose of the study is to examine whether demand for publicly funded sexually transmitted disease clinics changed after Affordable Care Act implementation. METHODS: The percentages of total incident sexually transmitted infections in Baltimore City that occurred at publicly funded sexually transmitted disease clinics were compared between the 3 years prior to and following the 2014 Medicaid and private insurance expansions. Risk factors associated with diagnosis at sexually transmitted disease clinics were identified using log binomial regression...
May 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29775088/an-assessment-of-the-uk-inpatient-care-for-heart-failure-patients-with-diabetes
#10
Lihua Wu, Jackie Cleator, Mamas Mamas, Christi Deaton
BACKGROUND: Diabetes is a common co-morbidity for patients with heart failure. Diabetes as a co-morbidity means that inpatient care should focus on both conditions to maximize the treatment regimen. However, this pressing issue is not widely researched and so it is unclear whether the acute care management needs of these patients are being met. AIMS: (1) To assess the differences in the number of hospital readmissions between patients with heart failure and patients with heart failure-diabetes; (2) to assess the use of integrated care approach for patients with heart failure-diabetes during the index heart failure-related admission; (3) to explore patient experiences of admissions...
May 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29774262/the-need-to-improve-fertility-awareness
#11
Joyce Harper, Jacky Boivin, Helen C O'Neill, Kate Brian, Jennifer Dhingra, Grace Dugdale, Genevieve Edwards, Lucy Emmerson, Bola Grace, Alison Hadley, Laura Hamzic, Jenny Heathcote, Jessica Hepburn, Lesley Hoggart, Fiona Kisby, Sue Mann, Sarah Norcross, Lesley Regan, Susan Seenan, Judith Stephenson, Harry Walker, Adam Balen
Women and men globally are delaying the birth of their first child. In the UK, the average age of first conception in women is 29 years. Women experience age-related fertility decline so it is important that men and women are well-informed about this, and other aspects of fertility. A group of UK stakeholders have established the Fertility Education Initiative to develop tools and information for children, adults, teachers, parents and healthcare professionals dedicated to improving knowledge of fertility and reproductive health...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29767779/survival-outcomes-after-intracranial-hemorrhage-in-liver-disease
#12
Carlito Lagman, Daniel T Nagasawa, Daniel Azzam, John P Sheppard, Cheng Hao Jacky Chen, Vera Ong, Thien Nguyen, Giyarpuram N Prashant, Tianyi Niu, Alexander M Tucker, Won Kim, Fady M Kaldas, Nader Pouratian, Ronald W Busuttil, Isaac Yang
BACKGROUND: Survival outcomes for patients with liver disease who suffer an intracranial hemorrhage (ICH) have not been thoroughly investigated. OBJECTIVE: To understand survival outcomes for 3 groups: (1) patients with an admission diagnosis of liver disease (end-stage liver disease [ESLD] or non-ESLD) who developed an ICH in the hospital, (2) patients with ESLD who undergo either operative vs nonoperative management, and (3) patients with ESLD on the liver transplant waitlist who developed an ICH in the hospital...
May 15, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29766581/corannulene-incorporated-aie-nanodots-with-highly-suppressed-nonradiative-decay-for-boosted-cancer-phototheranostics-in-vivo
#13
Xinggui Gu, Xiaoyan Zhang, Huili Ma, Shaorui Jia, Pengfei Zhang, Yanjun Zhao, Qian Liu, Jianguo Wang, Xiaoyan Zheng, Jacky W Y Lam, Dan Ding, Ben Zhong Tang
Fluorescent nanoparticles (NPs) based on luminogens with aggregation-induced emission characteristic (AIEgens), namely AIE dots, have received wide attention because of their antiquenching attitude in emission and reactive oxygen species (ROS) generation when aggregated. However, few reports are available on how to control and optimize their fluorescence and ROS generation ability. Herein, it is reported that enhancing the intraparticle confined microenvironment is an effective approach to advanced AIE dots, permitting boosted cancer phototheranostics in vivo...
May 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29764918/a-feed-forward-relay-integrates-the-regulatory-activities-of-bicoid-and-orthodenticle-via-sequential-binding-to-suboptimal-sites
#14
Rhea R Datta, Jia Ling, Jesse Kurland, Xiaotong Ren, Zhe Xu, Gozde Yucel, Jackie Moore, Leila Shokri, Isabel Baker, Timothy Bishop, Paolo Struffi, Rimma Levina, Martha L Bulyk, Robert J Johnston, Stephen Small
The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster , another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo patterning. Bcd is distributed as a long-range maternal gradient and activates transcription of a large number of target genes, including otd Otd and Bcd bind similar DNA sequences in vitro, but how their transcriptional activities are integrated to pattern anterior regions of the embryo is unknown...
May 15, 2018: Genes & Development
https://www.readbyqxmd.com/read/29760067/sequencing-based-counting-and-size-profiling-of-plasma-epstein-barr-virus-dna-enhance-population-screening-of-nasopharyngeal-carcinoma
#15
W K Jacky Lam, Peiyong Jiang, K C Allen Chan, Suk H Cheng, Haiqiang Zhang, Wenlei Peng, O Y Olivia Tse, Yu K Tong, Wanxia Gai, Benny C Y Zee, Brigette B Y Ma, Edwin P Hui, Anthony T C Chan, John K S Woo, Rossa W K Chiu, Y M Dennis Lo
Circulating tumor-derived DNA testing for cancer screening has recently been demonstrated in a prospective study on identification of nasopharyngeal carcinoma (NPC) among 20,174 asymptomatic individuals. Plasma EBV DNA, a marker for NPC, was detected using real-time PCR. While plasma EBV DNA was persistently detectable in 97.1% of the NPCs identified, ∼5% of the general population had transiently detectable plasma EBV DNA. We hypothesized that EBV DNA in plasma of subjects with or without NPC may have different molecular characteristics...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29758037/a-systematic-review-of-human-and-animal-leptospirosis-in-the-pacific-islands-reveals-pathogen-and-reservoir-diversity
#16
Vanina Guernier, Cyrille Goarant, Jackie Benschop, Colleen L Lau
BACKGROUND: The Pacific Islands have environmental conditions highly favourable for transmission of leptospirosis, a neglected zoonosis with highest incidence in the tropics, and Oceania in particular. Recent reports confirm the emergence and outbreaks of leptospirosis in the Pacific Islands, but the epidemiology and drivers of transmission of human and animal leptospirosis are poorly documented, especially in the more isolated and less developed islands. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic review of human and animal leptospirosis within 25 Pacific Islands (PIs) in Polynesia, Melanesia, Micronesia, as well as Easter Island and Hawaii...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29758018/the-work-ability-of-hong-kong-construction-workers-in-relation-to-individual-and-work-related-factors
#17
Jacky Y K Ng, Alan H S Chan
The shortage in Hong Kong of construction workers is expected to worsen in future due to the aging population and increasing construction activity. Construction work is dangerous and to help reduce the premature loss of construction workers due to work-related disabilities, this study measured the work ability of 420 Hong Kong construction workers with a Work Ability Index (WAI) which can be used to predict present and future work performance. Given the importance of WAI, in this study the effects of individual and work-related factors on WAI were examined to develop and validate a WAI model to predict how individual and work-related factors affect work ability...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29756536/intervention-for-a-lexical-reading-and-spelling-difficulty-in-two-greek-speaking-primary-age-children
#18
Aris R Terzopoulos, Georgia Z Niolaki, Jackie Masterson
An intervention study was carried out with two nine-year-old Greek-speaking dyslexic children. Both children were slow in reading single words and text and had difficulty in spelling irregularly spelled words. One child was also poor in non-word reading. Intervention focused on spelling in a whole-word training using a flashcard technique that had previously been found to be effective with English-speaking children. Post-intervention assessments conducted immediately at the end of the intervention, one month later and then five months later showed a significant improvement in spelling of treated words that was sustained over time...
May 14, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29755174/clinical-diagnostic-tests-versus-medial-branch-blocks-for-adults-with-persisting-cervical-zygapophyseal-joint-pain-a-systematic-review-and-meta-analysis
#19
Kendra Usunier, Mark Hynes, James Michael Schuster, Annie Cornelio-Jin Suen, Jackie Sadi, David Walton
Purpose: A systematic review and meta-analysis were performed to identify clinical tests for diagnosing cervical zygapophyseal joint pain (CZP) and to determine their diagnostic accuracy. Method: A search strategy was carried out to find relevant evidence published in CINAHL, Embase, MEDLINE, and PEDro from 1980 to January 1, 2015, pertaining to the clinical diagnosis of CZP. Quality assessment was completed using the Quality Assessment of Diagnostic Accuracy Studies-2. Results were analyzed to pool sensitivity and specificity and clarify diagnostic value...
2018: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/29753050/sex-specific-differences-in-corticosterone-secretion-behavioral-phenotypes-and-expression-of-trkb-t1-and-trkb-fl-receptor-isoforms-impact-of-systemic-trkb-inhibition-and-combinatory-stress-exposure-in-adolescence
#20
Idu Azogu, Jacky Liang, Helene Plamondon
Stress exposure has been implicated in the development of mood disorders, although little is known about the lasting effects of repeated stress during the adolescent period on sex-specific differences in endocrine and plasticity-signaling responses in adulthood. Using a 10-day combinatory stress paradigm (postnatal day (PND) 26 to 35), we examined sex-specific impact of adolescent stress and inhibition of tyrosine-related kinase B (TrkB) receptor (ANA-12; 0.5 mg/kg, i.p.) on 1) adolescent blood corticosterone levels, 2) adult locomotion and anxiety behavior, and 3) region-specific differences in endogenous TrkB full-length (TrkB...
May 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
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