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https://www.readbyqxmd.com/read/28635982/research-ethics-in-big-data
#1
Marilyn J Hammer
The ethical conduct of research includes, in part, patient agreement to participate in studies and the protection of health information. In the evolving world of data science and the accessibility of large quantities of web-based data created by millions of individuals, novel methodologic approaches to answering research questions are emerging. This article explores research ethics in the context of big data.
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28632250/measurement-of-hyperglycemia-and-impact-on-health-outcomes-in-people-with-cancer-challenges-and-opportunities
#2
Susan Storey, Marilyn J Hammer
PROBLEM IDENTIFICATION: Poor health outcomes have been associated with hyperglycemia in patients with and without diabetes. However, the impact of hyperglycemia on the health-related outcomes of patients with cancer has shown conflicting results. The purpose of this review was to explore definitions and measurement issues related to the assessment of hyperglycemia and the subsequent impact on the findings of health-related outcomes in adults with cancer.
. LITERATURE SEARCH: Four electronic databases were searched...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28632249/ethical-considerations-when-using-social-media-for-research
#3
Marilyn J Hammer
Because of its adaptation across age groups and populations, social media is being used as a venue for the conduction of research studies. The implications for use of social media to streamline data collection and analyses to understand epidemiologic effects of disease are intriguing. Public access to personalized Internet-based searches and conversations for patients with or at risk for cancer can potentially allow providers to target individuals for earlier interventions and improved outcomes. Although publicly posted, the use of personal information to solicit research participants, implement interventions, or abstract information for research studies raises questions regarding maintaining the ethical conduct of research...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28631992/validity-of-a-verbal-incidental-learning-measure-from-the-wais-iv-in-older-adults
#4
Dustin B Hammers, Amanda M Kucera, Stephanie J Card, Kathryn A Tolle, Taylor J Atkinson, Kevin Duff, Robert J Spencer
Incidental memory may reflect a form of learning in everyday life, although it is not consistently evaluated during standard neuropsychological evaluations. Further validation of a recently created measure of verbal Incidental Learning (IL) from the Wechsler Adult Intelligence Scale-IV is necessary to understand the utility of such a measure in clinical settings. Sixty-eight adults aged 50 to 89 were recruited from a Cognitive Disorders Clinic while receiving a standard neuropsychological assessment, along with two additional measures of IL...
March 2, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28630187/cumulative-effect-of-an-antimicrobial-stewardship-and-rapid-diagnostic-testing-bundle-on-early-streamlining-of-antimicrobial-therapy-in-gram-negative-bloodstream-infections
#5
P B Bookstaver, E B Nimmich, T J Smith, J A Justo, J Kohn, K L Hammer, C Troficanto, H A Albrecht, M N Al-Hasan
OBJECTIVES: The use of rapid diagnostic tests (RDT) enhances antimicrobial stewardship programs (ASP) interventions in optimization of antimicrobial therapy. This quasi-experimental cohort study evaluates the combined impact of an ASP/RDT bundle on appropriateness of empirical antimicrobial therapy (EAT) and time to de-escalation of broad-spectrum agents (BSAA) in gram-negative bloodstream infections (GNBSI). METHODS: ASP/RDT bundle consisted of a system-wide GNBSI treatment guidelines, prospective stewardship monitoring, and sequential introduction of two RDTs, Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) and FilmArray® Blood Culture Identification (BCID) panel...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28620373/mechanisms-of-autoantibody-induced-pathology
#6
REVIEW
Ralf J Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M Hammers, Jon M Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A Manz, Falk Nimmerjahn
Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects. To foster knowledge in autoantibody-induced pathology and to encourage development of urgently needed novel therapeutic strategies, we here categorized autoantibodies according to their effects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28619149/abortion-and-mortality-in-farm-mink-neovison-vison-associated-with-feed-born-clostridium-limosum
#7
Anne Sofie Hammer, Lars Andresen, Bent Aalbæk, Peter Damborg, Vilhelm Weiss, Mette Line Christiansen, Søren Selsing, Martin Iain Bahl
Disease in mink clinically characterized by abortion and increased mortality among pregnant female mink on 28 Danish farms was observed during April and May 2015. Most of these farms suffered extensive disease problems, including a significant increase in the number of mated females without litters. Pathological, microbiological and molecular biological methods were applied to investigate the cause of disease. Necropsies of animals found dead revealed fragile and partially dissolved (liquefying) uterine tissue, with the presence of Gram positive rod-shaped bacteria...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28617165/transplant-professionals-perceptions-of-long-term-care-residents-candidacy-for-kidney-transplantation
#8
Megan Urbanski, Teri Browne, Mythili Ghanta, Serban Constantinescu, Avrum Gillespie, Heather Hammer, Heather Traino
CONTEXT: Given the aging end-stage renal disease (ESRD) population, kidney transplant (KTx) centers may experience an increase in referrals of patients living in long-term care (LTC) settings (eg, skilled nursing facilities, assisted living facilities, group homes, and boarding homes). OBJECTIVE: To identify best practices among KTx professionals when considering individuals in LTC settings for transplantation. DESIGN AND SETTING: A cross-sectional survey administered online to US transplant professionals via e-mail LISTSERVs and other professional networks...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28611619/hammering-does-not-fit-fitts-law
#9
Tadej Petrič, Cole S Simpson, Aleš Ude, Auke J Ijspeert
While movement is essential to human wellbeing, we are still unable to reproduce the deftness and robustness of human movement in automatons or completely restore function to individuals with many types of motor impairment. To better understand how the human nervous system plans and controls movements, neuromechanists employ simple tasks such as upper extremity reaches and isometric force tasks. However, these simple tasks rarely consider impacts and may not capture aspects of motor control that arise from real-world complexity...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28609989/freshwater-fishes-of-northern-australia
#10
Bradley J Pusey, Damien W Burrows, Mark J Kennard, Colton N Perna, Peter J Unmack, Quentin Allsop, Michael P Hammer
Northern Australia is biologically diverse and of national and global conservation signicance. Its ancient landscape contains the world's largest area of savannah ecosystem in good ecological condition and its rivers are largely free-flowing. Agriculture, previously confined largely to open range-land grazing, is set to expand in extent and to focus much more on irrigated cropping and horticulture. Demands on the water resources of the region are thus, inevitably increasing. Reliable information is required to guide and inform development and help plan for a sustainable future for the region which includes healthy rivers that contain diverse fish assemblages...
April 11, 2017: Zootaxa
https://www.readbyqxmd.com/read/28606113/magnetic-resonance-imaging-and-computed-tomography-as-tools-for-the-investigation-of-sperm-whale-physeter-macrocephalus-teeth-and-eye
#11
Aage Kristian Olsen Alstrup, Ole Lajord Munk, Trine Hammer Jensen, Lasse Fast Jensen, Abdi Hedayat, Brian Hansen
BACKGROUND: Scanning techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) are useful tools in veterinary and human medicine. Here we demonstrate the usefulness of these techniques in the study of the anatomy of wild marine mammals as part of a necropsy. MRI and CT scans of sperm whale teeth (n = 4) were performed. The methods were compared and further compared to current standard methods for evaluation of tooth layering. For MRI a zero echo time sequence was used, as previously done for imaging of intact human teeth...
June 12, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28604116/the-cognitive-decline-in-older-patients-with-end-stage-renal-disease-cope-study-rationale-and-design
#12
Noeleen Berkhout-Byrne, Marije H Kallenberg, André Gaasbeek, Ton J Rabelink, Sebastiaan Hammer, Mark A van Buchem, Matthias J van Osch, Lucia J M Kroft, Henk Boom, Simon P Mooijaart, Marjolijn van Buren
BACKGROUND: Older patients with end stage renal disease (ESRD) are at increased risk for cognitive decline, but detailed studies of the magnitude of cognitive decline on dialysis or comprehensive conservative management (CCM) are lacking and the underlying pathophysiological mechanisms have poorly been studied. OBJECTIVE: To describe the rationale and design of the COPE study. Study objectives are firstly to examine the severity of cognitive impairment in older patients reaching ESRD before dialysis and the rate of decline after dialysis or CCM initiation...
June 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28602426/estimation-on-separation-efficiency-of-aluminum-from-base-cap-of-spent-fluorescent-lamp-in-hammer-crusher-unit
#13
Seung-Whee Rhee
In order to separate aluminum from the base-cap of spent fluorescent lamp (SFL), the separation efficiency of hammer crusher unit is estimated by introducing a binary separation theory. The base-cap of SFL is composed by glass fragment, binder, ferrous metal, copper and aluminum. The hammer crusher unit to recover aluminum from the base-cap consists of 3stages of hammer crusher, magnetic separator and vibrating screen. The optimal conditions of rotating speed and operating time in the hammer crusher unit are decided at each stage...
June 8, 2017: Waste Management
https://www.readbyqxmd.com/read/28601570/agreement-among-neuropsychological-and-behavioral-data-and-pib-findings-in-diagnosing-frontotemporal-dementia
#14
Kelly A Ryan, Dustin Hammers, Angeline DeLeon, Hande Bilen, Kirk Frey, James Burke, Roger Albin, Nancy Barbas, Judith Heidebrink, Bruno Giordani
Diagnostic inaccuracies have been reported in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD) using clinical data alone. The [(11)C]-PiB PET scan offers a new method of identifying AD based on the detection of amyloid deposits. Our study investigated whether there was an agreement between neuropsychological and behavioral data and PiB findings in the diagnosis of FTD. Participants were 32 patients diagnosed with suspected FTD by clinical consensus. All participants underwent neuropsychological testing and PiB imaging...
June 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28595322/the-effects-of-bit-wear-on-respirable-silica-dust-noise-and-productivity-a-hammer-drill-bench-study
#15
Paul Carty, Michael R Cooper, Alan Barr, Richard L Neitzel, John Balmes, David Rempel
Objectives: Hammer drills are used extensively in commercial construction for drilling into concrete for tasks including rebar installation for structural upgrades and anchor bolt installation. This drilling task can expose workers to respirable silica dust and noise. The aim of this pilot study was to evaluate the effects of bit wear on respirable silica dust, noise, and drilling productivity. Method: Test bits were worn to three states by drilling consecutive holes to different cumulative drilling depths: 0, 780, and 1560 cm...
June 8, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28593647/diets-and-trophic-guilds-of-small-fishes-from-coastal-marine-habitats-in-western-taiwan
#16
J P Egan, U-S Chew, C-H Kuo, V Villarroel-Diaz, P J Hundt, N G Iwinski, M P Hammer, A M Simons
The diets and trophic guilds of small fishes were examined along marine sandy beaches and in estuaries at depths <1·5 m in western Taiwan, Republic of China. Copepods were the most frequently identified item in fish guts, indicating they are key prey for the fish assemblages studied. Piscivore, crustacivore, detritivore, omnivore, zooplanktivore and terrestrial invertivore trophic guilds were identified. The zooplanktivore guild contained the most fish species. Maximum prey size consumption was positively correlated with standard length (LS ) in seven species and at the assemblage level and negatively correlated with LS in a single detritivorous species...
June 7, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28591667/exposure-to-residential-road-traffic-noise-prior-to-conception-and-time-to-pregnancy
#17
Jeppe Schultz Christensen, Ole Raaschou-Nielsen, Matthias Ketzel, Cecilia Høst Ramlau-Hansen, Bodil Hammer Bech, Jørn Olsen, Mette Sørensen
OBJECTIVES: To examine the association between residential road traffic noise and fecundity estimated by time to pregnancy (TTP). DESIGN: We identified 65,201 mothers from the Danish National Birth Cohort with self-reported information on TTP collected through computer assisted telephone interviews. Road traffic noise was modelled at all historical addresses and expressed as time-weighted means for periods corresponding to individual TTP. Associations were analyzed using logistic regression for analyses of dichotomous outcomes and ordinal logistic regression for TTP in four categories, adjusting for maternal age at conception, disposable household income, education and air pollution (NOx)...
June 4, 2017: Environment International
https://www.readbyqxmd.com/read/28591165/dichloroacetate-affects-proliferation-but-not-apoptosis-in-canine-mammary-cell-lines
#18
Tatjana P Harting, Mandy Stubbendorff, Susanne C Hammer, Patrik Schadzek, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte
Targeting mitochondrial energy metabolism is a novel approach in cancer research and can be traced back to the description of the Warburg effect. Dichloroacetate, a controversially discussed subject of many studies in cancer research, is a pyruvate dehydrogenase kinase inhibitor. Dichloroacetate causes metabolic changes in cancerous glycolysis towards oxidative phosphorylation via indirect activation of pyruvate dehydrogenase in mitochondria. Canine mammary cancer is frequently diagnosed but after therapy prognosis still remains poor...
2017: PloS One
https://www.readbyqxmd.com/read/28583434/27-hydroxycholesterol-a-novel-player-in-molecular-carcinogenesis-of-breast-and-prostate-cancer
#19
REVIEW
Gurdeep Marwarha, Shaneabbas Raza, Kimberly Hammer, Othman Ghribi
Several studies have suggested an etiological role for hypercholesterolemia in the pathogenesis of breast cancer and prostate cancer (PCa). However, the molecular mechanisms that underlie and mediate the hypercholesterolemia-fostered increased risk for breast cancer and PCa are yet to be determined. The discovery that the most abundant cholesterol oxidized metabolite in the plasma, 27 hydroxycholesterol (27-OHC), is a selective estrogen receptor modulator (SERM) and an agonist of Liver X receptors (LXR) partially fills the void in our understanding and knowledge of the mechanisms that may link hypercholesterolemia to development and progression of breast cancer and PCa...
June 2, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28581798/nuclear-physics-around-the-unitarity-limit
#20
Sebastian König, Harald W Grießhammer, H-W Hammer, U van Kolck
We argue that many features of the structure of nuclei emerge from a strictly perturbative expansion around the unitarity limit, where the two-nucleon S waves have bound states at zero energy. In this limit, the gross features of states in the nuclear chart are correlated to only one dimensionful parameter, which is related to the breaking of scale invariance to a discrete scaling symmetry and set by the triton binding energy. Observables are moved to their physical values by small perturbative corrections, much like in descriptions of the fine structure of atomic spectra...
May 19, 2017: Physical Review Letters
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