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https://www.readbyqxmd.com/read/29350941/immotile-active-matter-activity-from-death-and-reproduction
#1
Arben Kalziqi, David Yanni, Jacob Thomas, Siu Lung Ng, Skanda Vivek, Brian K Hammer, Peter J Yunker
Unlike equilibrium atomic solids, biofilms-soft solids composed of bacterial cells-do not experience significant thermal fluctuations at the constituent level. However, living cells stochastically reproduce and die, provoking a mechanical response. We investigate the mechanical consequences of cellular death and reproduction by measuring surface-height fluctuations of biofilms containing two mutually antagonistic strains of Vibrio cholerae that kill one another on contact via the type VI secretion system. While studies of active matter typically focus on activity via constituent mobility, here, activity is mediated by reproduction and death events in otherwise immobilized cells...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29343608/direct-quantification-of-cytochromes-p450-and-drug-transporters-a-rapid-targeted-mass-spectrometry-based-immunoassay-panel-for-tissues-and-cell-culture-lysates
#2
Frederik Weib, Helen Sophie Hammer, Kathrin Klein, Hannes Planatscher Planatscher, Ulrich M Zanger, Agneta Noren, Christine Wegler, Per Artursson, Thomas O Joos, Oliver Poetz
The quantification of drug metabolizing enzymes and transporters has recently been revolutionized on the basis of targeted proteomic approaches. Isotope-labeled peptides are used as standards for the quantification of the corresponding proteins in enzymatically fragmented samples. However, hurdles in these approaches are low throughput and tedious sample pre-fractionation steps prior to mass spectrometry read-out. We have developed an assay platform using sensitive and selective immunoprecipitation coupled with mass spectrometric read-out allowing the quantification of proteins directly from whole cell lysates using less than 20,000 cells per analysis...
January 17, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29342316/solvent-free-enzyme-activity-quick-high-yielding-mechano-enzymatic-hydrolysis-of-cellulose-into-glucose
#3
Fabien Hammerer, Leigh Loots, Jean-Louis Do, J P Daniel Therien, Christopher W Nickels, Tomislav Friscic, Karine Auclair
Mechanochemistry enables enzymatic cleavage of cellulose into glucose without bulk solvents, acids, other aggressive reagents or substrate pre-treatment. This clean mechano-enzymatic process is also directly applicable to biomass, avoids many limitations associated with the use of cellulases, and produces glucose concentrations >3 times the highest obtained by conventional methods.
January 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29342277/finding-nemo-hybrid-assembly-with-oxford-nanopore-and-illumina-reads-greatly-improves-the-clownfish-amphiprion-ocellaris-genome-assembly
#4
Mun Hua Tan, Christopher M Austin, Michael P Hammer, Yin Peng Lee, Laurence J Croft, Han Ming Gan
Background: Some of the most widely recognised coral-reef fishes are clownfish or anemonefishes, members of the family Pomacentridae (subfamily: Amphiprioninae). They are popular aquarium species due to their bright colours, adaptability to captivity and fascinating behavior. Their breeding biology (sequential hermaphrodites) and symbiotic mutualism with sea anemones have attracted much scientific interest. Moreover, there are some curious geographic-based phenotypes which warrant investigation...
January 12, 2018: GigaScience
https://www.readbyqxmd.com/read/29341653/quantum-nonlinear-optics-in-optomechanical-nanoscale-waveguides
#5
Hashem Zoubi, Klemens Hammerer
We show that strong nonlinearities at the few photon level can be achieved in optomechanical nanoscale waveguides. We consider the propagation of photons in cm-scale one-dimensional nanophotonic structures where stimulated Brillouin scattering (SBS) is strongly enhanced by radiation pressure coupling. We introduce a configuration that allows slowing down photons by several orders of magnitude via SBS from sound waves using two pump fields. Slowly propagating photons can then experience strong nonlinear interactions through virtual off-resonant exchange of dispersionless phonons...
September 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29337757/unusual-catheter-placement-on-chest-radiograph-two-dimensions-two-possible-locations-or-more
#6
Anna K Swenson Schalkwyk, Gregory B Hammer
No abstract text is available yet for this article.
February 2018: Anesthesiology
https://www.readbyqxmd.com/read/29336499/ecologically-driven-ultrastructural-and-hydrodynamic-designs-in-stomatopod-cuticles
#7
Lessa Kay Grunenfelder, Garrett Milliron, Steven Herrera, Isaias Gallana, Nicholas Yaraghi, Nigel Hughes, Kenneth Evans-Lutterodt, Pablo Zavattieri, David Kisailus
Ecological pressures and varied feeding behaviors in a multitude of organisms have necessitated the drive for adaptation. One such change is seen in the feeding appendages of stomatopods, a group of highly predatory marine crustaceans. Stomatopods include "spearers," who ambush and snare soft bodied prey, and "smashers," who bludgeon hard-shelled prey with a heavily mineralized club. The regional substructural complexity of the stomatopod dactyl club from the smashing predator Odontodactylus scyllarus represents a model system in the study of impact tolerant biominerals...
January 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29336014/response-to-yazdani-a-surgery-or-in-vitro-fertilisation-the-simplicity-of-this-question-belies-its-complexity-when-all-you-have-is-a-hammer-everything-looks-like-a-nail
#8
Jason Abbott
This is perhaps the most apt mantra of IVF (in vitro fertilisation) as a treatment in Australasia in this day and age. It is also important to note the truth in the identification of IVF being low skill-based, largely independent of the practitioner, but more importantly costly, and with few exceptions, only available in the private sector. Such revelations really require a rethink of the entire reproductive endocrinology and infertility (CREI) subspecialty. In fact, if there is only one solution to all fertility problems - that of the 'effective IVF procedure' - why not do away completely with the clinician and simply have nurse practitioners who oversee the identified issue of an individual or couple wanting a pregnancy? This in conjunction with the outstanding scientific advances that led to the initiation and promulgation of IVF really would reduce costs by cutting out the unnecessary clinician middle-person who is unimportant in the equation...
January 16, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29335326/attendance-of-routine-childcare-visits-in-primary-care-for-children-of-mothers-with-depression-a-nationwide-population-based-cohort-study
#9
Bente Kjær Lyngsøe, Claus Høstrup Vestergaard, Dorte Rytter, Mogens Vestergaard, Trine Munk-Olsen, Bodil Hammer Bech
BACKGROUND: Depression is a common and potentially debilitating illness worldwide. Attendance to routine childcare appointments is a key point of interest in the effort to improve the health and care for families facing depression. AIM: To evaluate the association between maternal depression and offspring non-attendance to the Danish childcare and vaccination programme (CCP) for children from 0-5 years of age. The CCP consists of seven separate visits and several vaccinations...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29335275/interplay-between-chrebp-and-srebp-1c-coordinates-postprandial-glycolysis-and-lipogenesis-in-livers-of-mice
#10
Albert G Linden, Shili Li, Hwa Y Choi, Fei Fang, Masashi Fukasawa, Kosaku Uyeda, Robert E Hammer, Jay D Horton, Luke J Engelking, Guosheng Liang
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in fatty acid (FA) synthesis, whereas glucose activates ChREBP, which activates both glycolysis and FA synthesis. Whether SREBP-1c and ChREBP act independently of one another is unknown. Here, we characterized mice with liver-specific deletion of ChREBP (L-Chrebp-/- mice). Hepatic ChREBP deficiency resulted in reduced mRNA levels of glycolytic and lipogenic enzymes, particularly in response to sucrose refeeding following fasting, a dietary regimen that elicits maximal lipogenesis...
January 15, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29331140/erratum-an-automated-nudged-elastic-band-method-j-chem-phys-145-094107-2016
#11
Esben L Kolsbjerg, Michael N Groves, Bjørk Hammer
No abstract text is available yet for this article.
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29330329/large-genomic-insertion-at-the-shh-locus-results-in-hammer-toes-through-enhancer-adoption
#12
Christina Paliou, Guillaume Andrey
No abstract text is available yet for this article.
January 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29328791/how-noisy-are-total-knee-and-hip-replacements
#13
Jonathan P Simpson, Andrew J Hamer
Orthopaedic theatre can be noisy. Fifty percent of orthopaedic theatre staff have features of noise-induced hearing loss (NIHL). In this study, decibel (dB) levels were recorded in 17 total knee replacements (TKRs) and 11 total hip replacements (THRs). Noise levels reached 105.6dB(A) using a hammer and 97.9dB(A) with an oscillating saw. Exposure to levels above 90dB (which occurred in every case) even for short time periods is proven to cause irreversible loss of hearing. Tools used in orthopaedic theatre produce impulse noises that can cause NIHL...
December 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29326820/a-case-of-intra-arterial-thrombolysis-with-alteplase-in-a-patient-with-hypothenar-hammer-syndrome-but-without-underlying-aneurysm
#14
Harshal Shukla, Vicken Yaghdjian, Issam Koleilat
Hypothenar hammer syndrome is a cause of symptomatic ischemia of the hand secondary to the formation of aneurysm or thrombosis of the ulnar artery in the setting of a complete or incomplete palmar arch. Acute occlusive thrombus or embolus of the hand represents a complex problem that often may require immediate surgical intervention. We report a case of acute unilateral arterial hand ischemia requiring catheter-directed thrombolysis with Alteplase therapy in a patient with acute occlusive arterial thrombosis of the left ulnar artery...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29325520/factors-associated-with-low-patient-satisfaction-in-out-of-hours-primary-care-in-denmark-a-population-based-cross-sectional-study
#15
Mette Tranberg, Peter Vedsted, Bodil Hammer Bech, Morten Bondo Christensen, Søren Birkeland, Grete Moth
BACKGROUND: Low patient satisfaction with the quality of out-of-hours primary care (OOH-PC) has been linked with several individual and organizational factors. However, findings have been ambiguous and may not apply to the Danish out-of-hours (OOH) setting in which general practitioners (GPs) perform the initial telephone triage. This study aimed to identify patient-related, GP-related and organizational factors associated with low patient satisfaction. METHODS: The study was based on data from a 1-year population-based survey of OOH-PC (LV-KOS) in the Central Denmark Region in 2010-2011...
January 11, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29325070/vaccine-induced-antibody-responses-modify-the-association-between-t-cell-immune-responses-and-hiv-1-infection-risk-in-hvtn-505
#16
Youyi Fong, Xiaoying Shen, Vicki C Ashley, Aaron Deal, Kelly E Seaton, Chenchen Yu, Shannon P Grant, Guido Ferrari, Allan C deCamp, Robert T Bailer, Richard A Koup, David Montefiori, Barton F Haynes, Marcella Sarzotti-Kelsoe, Barney S Graham, Lindsay N Carpp, Scott M Hammer, Magda Sobieszczyk, Shelly Karuna, Edith Swann, Edwin DeJesus, Mark Mulligan, Ian Frank, Susan Buchbinder, Richard M Novak, M Juliana McElrath, Spyros Kalams, Michael Keefer, Nicole A Frahm, Holly E Janes, Peter B Gilbert, Georgia D Tomaras
Background: HVTN 505 was an HIV-1 preventive vaccine efficacy trial of a DNA/recombinant adenovirus serotype 5 (rAd5) vaccine regimen. We assessed antibody responses measured one month post-final vaccination (Month 7) as correlates of HIV-1 acquisition risk. Methods: Binding antibody responses were quantified in serum samples from 25 primary endpoint vaccine cases (diagnosed with HIV-1 infection between Month 7 and 24) and 125 randomly sampled frequency-matched vaccine controls (HIV-1 negative at Month 24)...
January 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29321813/novel-concept-of-a-modular-hip-implant-could-contribute-to-less-implant-failure-in-tha-a-hypothesis
#17
Ronny Grunert, Stefan Schleifenbaum, Robert Möbius, Michael Kopper, Christian Rotsch, Welf-Guntram Drossel, Niels Hammer, Torsten Prietzel
Background: The modularity in total hip arthroplasty (THA) allows orthopaedic surgeons for an exact reconstruction of hip biomechanical parameters especially in revision and tumor arthroplasty. Modular structured femoral stems using taper junctions showed increased implant breakage in the recent past. Presentation of the hypothesis: We hypothesize that a novel modular stem-neck-interface leads to less implant breakage compared to conventional femoral stems. Testing of the hypothesis: For this purpose, a novel modular femoral stem for THA was to design and manufacture...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29321246/unique-perceptuomotor-control-of-stone-hammers-in-wild-monkeys
#18
Madhur Mangalam, Matheus Maia Pacheco, Patrícia Izar, Elisabetta Visalberghi, Dorothy Munkenbeck Fragaszy
We analysed the patterns of coordination of striking movement and perceptuomotor control of stone hammers in wild bearded capuchin monkeys, Sapajus libidinosus as they cracked open palm nut using hammers of different mass, a habitual behaviour in our study population. We aimed to determine why these monkeys cannot produce conchoidally fractured flakes as do contemporary human knappers or as did prehistoric hominin knappers. We found that the monkeys altered their patterns of coordination of movement to accommodate changes in hammer mass...
January 2018: Biology Letters
https://www.readbyqxmd.com/read/29321158/response-to-calprotectin-is-not-independent-from-baseline-erosion-in-predicting-radiological-progression-in-early-rheumatoid-arthritis-by-chevreau-et-al
#19
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Désirée van der Heijde, Tore Kristian Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen Andre Haavardsholm
No abstract text is available yet for this article.
January 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29314842/exploration-versus-exploitation-in-global-atomistic-structure-optimization
#20
Mathias Siggaard Jørgensen, Uffe Furlig Larsen, Karsten W Jacobsen, Bjørk Hammer
The ability to navigate vast energy landscapes of molecules, clusters, and solids is a necessity for discovering novel compounds in computational chemistry and materials science. For high-dimensional systems it is only computationally feasibly to search a small portion of the landscape, and hence the search strategy is of critical importance. Introducing Bayesian optimization concepts in an evolutionary algorithm framework, we quantify the concepts of exploration and exploitation in global minimum searches...
January 9, 2018: Journal of Physical Chemistry. A
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