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https://www.readbyqxmd.com/read/28630474/nanoassembly-routes-stimulate-conflicting-antibody-quantity-and-quality-for-transmission-blocking-malaria-vaccines
#1
Darren B Leneghan, Kazutoyo Miura, Iona J Taylor, Yuanyuan Li, Jing Jin, Karl D Brune, Martin F Bachmann, Mark Howarth, Carole A Long, Sumi Biswas
Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds or virus like particles (VLPs). Typically such studies demonstrate improved antibody titer comparing monomeric and nano-arrayed antigen. There are many such studies and scaffold technologies, but minimal side-by-side evaluation of platforms for both the amount and efficacy of antibodies induced. Here we present direct comparison of three leading platforms displaying the promising malaria transmission-blocking vaccine (TBV) target Pfs25...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630465/changes-in-pore-structure-of-coal-caused-by-coal-to-gas-bioconversion
#2
Rui Zhang, Shimin Liu, Jitendra Bahadur, Derek Elsworth, Yi Wang, Guanglong Hu, Yanna Liang
Microbial enhanced coalbed methane (ME-CBM) recovery is critically examined as a viable technology for natural gas recovery from coalbed methane (CBM) reservoirs. Since the majority of gas-in-place (GIP) is stored as an adsorbed phase in fine pores of coal matrix, the nano-pore structure directly influences gas storage and transport properties. Only limited studies have quantified the alteration of the nano-pore structure due to ME-CBM treatment. This study examines the evolution of the pore structure using a combination of small angle X-ray scattering (SAXS), low-pressure N2 and CO2 adsorption (LPGA) and high-pressure methane adsorption methods...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629080/efficient-megalin-targeted-delivery-to-renal-proximal-tubular-cells-mediated-by-modified-polymyxin-b-polyethylenimine-based-nano-gene-carriers
#3
Fatemeh Oroojalian, Ali Hossein Rezayan, Faramarz Mehrnejad, Azadeh Hashem Nia, Wayne Thomas Shier, Khalil Abnous, Mohammad Ramezani
Non-viral vectors have attracted great interest, as they are simple to prepare, easy to modify and relatively safe, compared to viral vectors. Kidney-targeted gene delivery systems depict a promising technology to improve drug efficacy in renal diseases treatments. In order to develop a novel kidney-targeted gene delivery system, we synthesized polyamine-PEI conjugates using polymyxin B as ligand and investigated their potential targeting efficiency. After grafting either PEI25 kDa or PEI10 kDa with polymyxin B through amidation reaction, the modified-polymyxin-PEI/DNA-nanoplexes were produced via electrostatic attraction between the cationic polymers and EGFP plasmid...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28618240/omics-for-precious-rare-biosamples-characterization-of-ancient-human-hair-by-a-proteomic-approach
#4
Margaux Fresnais, Pascale Richardin, Marcela Sepúlveda, Emmanuelle Leize-Wagner, Armelle Charrié-Duhaut
Omics technologies have far-reaching applications beyond clinical medicine. A case in point is the analysis of ancient hair samples. Indeed, hair is an important biological indicator that has become a material of choice in archeometry to study the ancient civilizations and their environment. Current characterization of ancient hair is based on elemental and structural analyses, but only few studies have focused on the molecular aspects of ancient hair proteins-keratins-and their conservation state. In such cases, applied extraction protocols require large amounts of raw hair, from 30 to 100 mg...
June 15, 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28614735/enhanced-biomimic-bactericidal-surfaces-by-coating-with-positively-charged-zif-nano-dagger-arrays
#5
Yuan Yuan, Yugen Zhang
Cicada wing surfaces are covered with dense patterns of nano-pillar structure that prevent bacterial growth by rupturing adhered microbial cells. To mimic the natural nano-pillar structure, we developed a general and simple method to grow metal organic framework (MOF) nano-dagger arrays on a wide range of surfaces. These nano-daggers possess high bactericidal activity, with log reduction >7 for Escherichia coli and Staphylococcus aureus. It was hypothesized that the positively-charged ZIF-L nano-dagger surfaces enhance bacterial cell adhesion, facilitating selective and efficient bacteria killing by the rigid and sharp nano-dagger tips...
June 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28613388/self-assembled-polymeric-ionic-liquid-functionalized-cellulose-nano-crystals-constructing-3d-ion-conducting-channels-within-ionic-liquid-based-composite-polymer-electrolytes
#6
Xuan Qing Shi, Qing Xia, Xiao Xiang, Yun Sheng Ye, Yan Hai Peng, Gang Zhi Xue, Lin Xiao Xie, Yiu-Wing Mai
Composite polymeric and ionic liquid (IL) electrolytes are some of the most promising electrolyte systems for safer battery technology. Although much effort has been directed towards enhancing the transport properties of polymer electrolytes (PEs) through nanoscopic modification by incorporating nano-fillers, it is still difficult to construct ideal ion conducting networks. Here, a novel class of three-dimensional self-assembled polymeric ionic liquid (PIL)-functionalized cellulose nano-crystals (CNC) confining ILs in surface-grafted PIL polymer chains, able to form colloidal crystal polymer electrolytes (CCPE), is reported...
June 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28611604/on-the-accuracy-of-in-vivo-ethanol-and-acetaldehyde-monitoring-a-key-tile-in-the-puzzle-of-acetaldehyde-as-a-neuroactive-agent
#7
REVIEW
Paolo Enrico, Marco Diana
Over the last 20 years researchers have explored the postulated role of acetaldehyde (ACD) as a mediator of some of the actions of ethanol (EtOH) in the central nervous system (CNS). However, efforts have been hampered mainly by the difficulty of directly measuring in vivo EtOH and ACD levels in the CNS and thus, our knowledge is based on indirect evidences. Although technically challenging, the development of reliable methods for in vivo measurement of ACD and EtOH is of paramount importance to solve the "puzzle of acetaldehyde as a neuroactive agent...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28609112/principles-of-electrospraying-a-new-approach-in-protection-of-bioactive-compounds-in-foods
#8
Ali Alehosseini, Behrouz Ghorani, Mahboobe Sarabi-Jamab, Nick Tucker
Electrospraying is a potential answer to the demands of nanoparticle fabrication such as scalability, reproducibility and effective encapsulation in food nanotechnology. Electrospraying (and the related process of electrospinning) both show promise as a novel delivery vehicle for supplementary food compounds since the process can be carried out from an aqueous solution, at room temperature and without coagulation chemistry to produce matrices or particulates in the micro-and nano-range. The presentation of core materials at the nanoscale improves target ability to specific areas of the digestive tract and gives improved control of release rate...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28608781/nano-and-microparticles-at-fluid-and-biological-interfaces
#9
Sabyasachi Dasgupta, Thorsten Auth, Gerhard Gompper
Systems with interfaces are abundant in both technological applications and biology. While a fluid interface separates two fluids, membranes separate the inside of vesicles from the outside, the interior of biological cells from the environment, and compartmentalize cells into organelles. The physical properties of interfaces are characterized by interface tension, those of membranes are characterized by bending and stretching elasticity. Amphiphilic molecules like surfactants that are added to a system with two immiscible fluids decrease the interface tension and induce a bending rigidity...
June 13, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28599108/probing-gap-plasmons-down-to-subnanometer-scales-using-collapsible-nanofingers
#10
Boxiang Song, Yuhan Yao, Roelof E Groenewald, Yunxiang Wang, He Liu, Yifei Wang, Yuanrui Li, Fanxin Liu, Stephen B Cronin, Adam M Schwartzberg, Stefano Cabrini, Stephan Haas, Wei Wu
Gap plasmonic nanostructures are of great interest due to their ability to concentrate light into small volumes. Theoretical studies, considering quantum mechanical effects, have predicted the optimal spatial gap between adjacent nanoparticles to be in the subnanometer regime in order to achieve the strongest possible field enhancement. Here, we present a technology to fabricate gap plasmonic structures with subnanometer resolution, high reliability, and high throughput using collapsible nanofingers. This approach enables us to systematically investigate the effects of gap size and tunneling barrier height...
June 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28589118/innovative-programmable-bio-nano-chip-digitizes-biology-using-sensors-that-learn-bridging-biomarker-discovery-and-clinical-implementation
#11
REVIEW
Nicolaos J Christodoulides, Michael P McRae, Timothy J Abram, Glennon W Simmons, John T McDevitt
The lack of standard tools and methodologies and the absence of a streamlined multimarker approval process have hindered the translation rate of new biomarkers into clinical practice for a variety of diseases afflicting humankind. Advanced novel technologies with superior analytical performance and reduced reagent costs, like the programmable bio-nano-chip system featured in this article, have potential to change the delivery of healthcare. This universal platform system has the capacity to digitize biology, resulting in a sensor modality with a capacity to learn...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28585942/progress-of-crystallization-in-microfluidic-devices
#12
REVIEW
Huan-Huan Shi, Yan Xiao, Steven Ferguson, Xin Huang, Na Wang, Hong-Xun Hao
Microfluidic technology provides a unique environment for the investigation of crystallization processes at the nano or meso scale. The convenient operation and precise control of process parameters, at these scales of operation enabled by microfluidic devices, are attracting significant and increasing attention in the field of crystallization. In this paper, developments and applications of microfluidics in crystallization research including: crystal nucleation and growth, polymorph and cocrystal screening, preparation of nanocrystals, solubility and metastable zone determination, are summarized and discussed...
June 6, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28584572/journey-of-trail-from-bench-to-bedside-and-its-potential-role-in-immuno-oncology
#13
REVIEW
George E Naoum, Donald J Buchsbaum, Fady Tawadros, Ammad Farooqi, Waleed O Arafat
Induction of apoptosis in cancer cells has increasingly been the focus of many therapeutic approaches in oncology field. Since its identification as a TNF family member, TRAIL (TNF-related apoptosis-inducing ligand) paved a new path in apoptosis inducing cancer therapies. Its selective ability to activate extrinsic and intrinsic cell death pathways in cancer cells only, independently from p53 mutations responsible for conventional therapeutics resistance, spotted TRAIL as a potent cancer apoptotic agent. Many recombinant preparations of TRAIL and death receptor targeting monoclonal antibodies have been developed and being tested pre-clinically and clinically both as a single agent and in combinations...
March 3, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28584234/stiff-light-strong-and-ductile-nano-structured-high-modulus-steel
#14
H Springer, C Baron, A Szczepaniak, V Uhlenwinkel, D Raabe
Structural material development for lightweight applications aims at improving the key parameters strength, stiffness and ductility at low density, but these properties are typically mutually exclusive. Here we present how we overcome this trade-off with a new class of nano-structured steel - TiB2 composites synthesised in-situ via bulk metallurgical spray-forming. Owing to the nano-sized dispersion of the TiB2 particles of extreme stiffness and low density - obtained by the in-situ formation with rapid solidification kinetics - the new material has the mechanical performance of advanced high strength steels, and a 25% higher stiffness/density ratio than any of the currently used high strength steels, aluminium, magnesium and titanium alloys...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28583328/3d-printed-tablets-loaded-with-polymeric-nanocapsules-an-innovative-approach-to-produce-customized-drug-delivery-systems
#15
R C R Beck, P S Chaves, A Goyanes, B Vukosavljevic, A Buanz, M Windbergs, A W Basit, S Gaisford
The generation of multi-functional drug delivery systems, namely solid dosage forms loaded with nano-sized carriers, remains little explored and is still a challenge for formulators. For the first time, the coupling of two important technologies, 3D printing and nanotechnology, to produce innovative solid dosage forms containing drug-loaded nanocapsules was evaluated here. Drug delivery devices were prepared by fused deposition modelling (FDM) from poly(ε-caprolactone) (PCL) and Eudragit(®) RL100 (ERL) filaments with or without a channelling agent (mannitol)...
June 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28580704/3d-laser-micro-and-nano-printing-challenges-for-chemistry
#16
Christopher Barner-Kowollik, Martin Bastemeyer, Eva Blasco, Mueller Patrick, Guillaume Delaittre, Benjamin Richter, Martin Wegener
3D printing is a powerful emerging technology for the tailored fabrication of advanced functional materials. The current review summarizes the state-of-the art with regard to 3D laser micro- and nano-printing and explores the critical chemical challenges limiting its full exploitation. These challenges are rationalized in five categories spanning the development of advanced functional materials for applications in cell biology and electronics to the chemical barriers that need to be overcome to enable fast writing velocities while enabling sub-diffraction coding...
June 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28579437/quality-by-design-of-nano-pharmaceuticals-a-state-of-the-art
#17
REVIEW
T Bastogne
Pharmaceutical Quality-by-Design is a risk-based approach of drug development relying on the understanding of both the product and the process. This state of the art analyzes 24 studies published during the last ten years. A risk modeling of the nanomaterial formulation and manufacturing is firstly presented. After a brief history of the QbD approach, its basic components are recalled in a second part. The most critical material attributes, process parameters, quality variables and measurement technologies are reviewed...
June 1, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28578273/biomimetic-mineralized-hierarchical-hybrid-scaffolds-based-on-in-situ-synthesis-of-nano-hydroxyapatite-chitosan-chondroitin-sulfate-hyaluronic-acid-for-bone-tissue-engineering
#18
Yimin Hu, Jingdi Chen, Tiantang Fan, Yujue Zhang, Yao Zhao, Xuetao Shi, Qiqing Zhang
Biomimetic mineralized hybrid scaffolds are widely used as natural bone substitute materials in tissue engineering by mimicking vital characters of extracellular matrix (ECM). However, the fabrication of hybrid scaffolds with suitable mechanical properties and good biocompatibility remains a challenge. To solve the problems mentioned above, biomimetic calcium phosphate mineralized organic-inorganic hybrid scaffold composed of nano hydroxyapatite (nHAP), Chitosan (CS), Chondroitin sulfate (CSA) and hyaluronic acid (HA) with hierarchical micro/nano structures was successfully developed...
May 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28576325/distinct-physiological-and-molecular-responses-in-arabidopsis-thaliana-exposed-to-aluminum-oxide-nanoparticles-and-ionic-aluminum
#19
Yujian Jin, Xiaoji Fan, Xingxing Li, Zhenyan Zhang, Liwei Sun, Zhengwei Fu, Michel Lavoie, Xiangliang Pan, Haifeng Qian
Nano-aluminium oxide (nAl2O3) is one of the most widely used nanomaterials. However, nAl2O3 toxicity mechanisms and potential beneficial effects on terrestrial plant physiology remain poorly understood. Such knowledge is essential for the development of robust nAl2O3 risk assessment. In this study, we studied the influence of a 10-d exposure to a total selected concentration of 98 μM nAl2O3 or to the equivalent molar concentration of ionic Al (AlCl3) (196 μM) on the model plant Arabidopsis thaliana on the physiology (e...
May 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28565781/design-and-implementation-of-fast-allergy-skin-test-detector-for-traditional-chinese-medicine-injections
#20
Ying Xiao, Yubin Zhao, Yanming Xie
Traditional Chinese medicine (TCM) injections are prepared from active substances extracted from TCMs and other natural medicines to establish scientific and technological methods, based on TCM hypotheses and experiences. A device was designed to provide a fast allergy skin test detector for TCM injections that could be applied to drugs of a single component or complex components. A novel fast allergy skin test detector for TCM injections was developed combining direct-current main, drug solution permeation devices of various shape that were compatible with the skin test electrode, nano-sponge patch adsorption, and flexible liposome coverage technologies with high-amplitude pulse...
May 2017: Experimental and Therapeutic Medicine
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