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https://www.readbyqxmd.com/read/28430279/microcontact-printing-with-aminosilanes-creating-biomolecule-micro-and-nanoarrays-for-multiplexed-microfluidic-bioassays
#1
Shivani Sathish, Sébastien G Ricoult, Kazumi Toda-Peters, Amy Q Shen
Microfluidic systems integrated with protein and DNA micro- and nanoarrays have been the most sought-after technologies to satisfy the growing demand for high-throughput disease diagnostics. As the sensitivity of these systems relies on the bio-functionalities of the patterned recognition biomolecules, the primary concern has been to develop simple technologies that enable biomolecule immobilization within microfluidic devices whilst preserving bio-functionalities. To address this concern, we introduce a two-step patterning approach to create micro- and nanoarrays of biomolecules within microfluidic devices...
April 21, 2017: Analyst
https://www.readbyqxmd.com/read/28424954/trendiness-in-human-arts-as-technology-transits-from-the-macro-to-nano
#2
EDITORIAL
David F Albertini
No abstract text is available yet for this article.
April 19, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28424550/doxorubicin-loaded-poly-lactic-co-glycolic-acid-nanoparticles-coated-with-chitosan-alginate-by-layer-by-layer-technology-for-antitumor-applications
#3
Fujuan Chai, Linlin Sun, Xinyi He, Jieli Li, Yuanfen Liu, Fei Xiong, Liang Ge, Thomas J Webster, Chunli Zheng
Natural polyelectrolyte multilayers of chitosan (CHI) and alginate (ALG) were alternately deposited on doxorubicin (DOX)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) with layer by layer self-assembly to control drug release for antitumor activity. Numerous factors which influenced the multilayer growth on nano-colloidal particles were studied: polyelectrolyte concentration, NaCl concentration and temperature. Then the growth regime of the CHI/ALG multilayers was elucidated. The coated NPs were characterized by transmission electron microscopy, atomic force microscopy, X-ray diffraction and a zeta potential analyzer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28424529/surface-dependent-scenarios-for-dissolution-driven-motion-of-growing-droplets
#4
Stefano Curiotto, Frédéric Leroy, Fabien Cheynis, Pierre Müller
Nano-droplets on a foreign substrate have received increasing attention because of their technological possible applications, for instance to catalyse the growth of nanowires. In some cases the droplets can move as a result of a reaction with the substrate. In this work we show that the substrate orientation, the surface morphology and the shape of the pits etched in the substrate by the droplets affect the droplet motion, so that a single mechanism (droplet-induced substrate dissolution) may lead to several unexpected droplet dynamics...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421428/how-has-cder-prepared-for-the-nano-revolution-a-review-of-risk-assessment-regulatory-research-and-guidance-activities
#5
Katherine M Tyner, Nan Zheng, Stephanie Choi, Xiaoming Xu, Peng Zou, Wenlei Jiang, Changning Guo, Celia N Cruz
The Nanotechnology Risk Assessment Working Group in the Center for Drug Evaluation and Research (CDER) within the United States Food and Drug Administration (FDA) was established to assess the potential impact of nanotechnology on drug products. One of the working group's major initiatives has been to conduct a comprehensive risk management exercise regarding the potential impact of nanomaterial pharmaceutical ingredients and excipients on drug product quality, safety, and efficacy. This exercise concluded that current review practices and regulatory guidance are capable of detecting and managing the potential risks to quality, safety, and efficacy when a drug product incorporates a nanomaterial...
April 18, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28416816/scalable-electrophysiology-in-intact-small-animals-with-nanoscale-suspended-electrode-arrays
#6
Daniel L Gonzales, Krishna N Badhiwala, Daniel G Vercosa, Benjamin W Avants, Zheng Liu, Weiwei Zhong, Jacob T Robinson
Electrical measurements from large populations of animals would help reveal fundamental properties of the nervous system and neurological diseases. Small invertebrates are ideal for these large-scale studies; however, patch-clamp electrophysiology in microscopic animals typically requires invasive dissections and is low-throughput. To overcome these limitations, we present nano-SPEARs: suspended electrodes integrated into a scalable microfluidic device. Using this technology, we have made the first extracellular recordings of body-wall muscle electrophysiology inside an intact roundworm, Caenorhabditis elegans...
April 17, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28414907/cell-isolation-and-recovery-using-hollow-glass-microspheres-coated-with-nanolayered-films-for-applications-in-resource-limited-settings
#7
Ziye Dong, Caroline C Ahrens, Dan Yu, Zhenya Ding, HyunTaek Lim, Wei Li
Established cell isolation and purification techniques such as FACS, isolation through magnetic micro/nano-particles and recovery via microfluidic devices have limited application as disposable technologies appropriate for point-of-care use in remote areas where lab equipment as well as electrical, magnetic, and optical sources are restricted. We report a simple yet effective method for cell isolation and recovery that requires neither specialized lab equipment nor any form of power source. Specifically, self-floating hollow glass microspheres were coated with an enzymatically degradable nanolayered film, and conjugated with antibodies to allow both fast capture and release of subpopulations of cells from a cell mixture...
April 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28414159/in-vitro-toxicological-effects-of-zinc-containing-nanoparticles-with-different-physico-chemical-properties
#8
Oskari Uski, Tiina Torvela, Olli Sippula, Tommi Karhunen, Hanna Koponen, Sirpa Peräniemi, Pasi Jalava, Mikko Happo, Jorma Jokiniemi, Maija-Riitta Hirvonen, Anna Lähde
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Recent nano-technological advances are leading to wide usage of metallic nanoparticles (NPs) in various fields. However, the increasing use of NPs has led to their release into environment and the toxicity of NPs on human health has become a concern. Moreover, there are inadvertently generated metallic NPs which are formed during various human activities (e.g. metal processing and energy production)...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28412848/proteomic-profile-of-serum-of-pregnant-women-carring-a-fetus-with-down-syndrome-using-nano-uplc-q-tof-ms-ms-technology
#9
Graciela Arelí López-Uriarte, Carlos Horacio Burciaga Flores, Víctor Manuel Torres de la Cruz, María Magdalena Medina Aguado, Viviana Maricela Gómez Puente, Liliana Nayeli Romero Gutiérrez, Laura Elia Martínez de Villarreal
INTRODUCTION: Prenatal diagnosis of Down syndrome (DS) is based on the calculated risk of maternal age, biochemical and ultrasonographic markers and recently by cfDNA. Differences in proteomic profiles may give an opportunity to find new biomarkers. OBJECTIVE: Characterize proteome of serum of mothers carrying DS fetus. MATERIAL AND METHODS: Blood serum samples of three groups of women were obtained, a) 10 non-pregnant, b) 10 pregnant with healthy fetus by ultrasound evaluation, c) 9 pregnant with DS fetus; Sample preparation was as follow: Albumin/IgG depletion, desalting, and trypsin digestion; the process was performed in nanoUPLC MS/MS...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28407935/omega-3-pufa-concentration-by-a-novel-pvdf-nano-composite-membrane-filled-with-nano-porous-silica-particles
#10
Samaneh Ghasemian, Mohammad Ali Sahari, Mohsen Barzegar, Hasan Ahmadi Gavlighi
In this study, polyvinylidene fluoride (PVDF) and nano-porous silica particle were used to fabricate an asymmetric nano-composite membrane. Silica particles enhanced the thermal stability of PVDF/SiO2 membranes; increasing the decomposition temperature from 371°C to 408°C. Cross sectional morphology showed that silica particles were dispersed in polymer matrix uniformly. However, particle agglomeration was found at higher loading of silica (i.e., 20 by weight%). The separation performance of nano-composite membranes was also evaluated using the omega-3 polyunsaturated fatty acids (PUFA) concentration at a temperature and pressure of 30°C and 4bar, respectively...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28406304/dynamic-control-of-the-vortex-pinning-potential-in-a-superconductor-using-current-injection-through-nanoscale-patterns
#11
Yoav Kalcheim, Eran Katzir, Felix Zeides, Nadav Katz, Yossi Paltiel, Oded Millo
Control over the vortex potential at the nanoscale in a superconductor is a subject of great interest for both fundamental and technological reasons. Many methods for achieving artificial pinning centers have been demonstrated, for example, with magnetic nanostructures or engineered imperfections, yielding many intriguing effects. However, these pinning mechanisms do not offer dynamic control over the strength of the patterned vortex potential because they involve static nanostructures created in or near the superconductor...
April 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28395856/micro-and-nano-bio-based-delivery-systems-for-food-applications-in-vitro-behavior
#12
REVIEW
Lívia de Souza Simões, Daniel A Madalena, Ana C Pinheiro, José A Teixeira, António A Vicente, Óscar L Ramos
Micro- and nanoencapsulation is an emerging technology in the food field that potentially allows the improvement of food quality and human health. Bio-based delivery systems of bioactive compounds have a wide variety of morphologies that influence their stability and functional performance. The incorporation of bioactive compounds in food products using micro- and nano-delivery systems may offer extra health benefits, beyond basic nutrition, once their encapsulation may provide protection against undesired environmental conditions (e...
March 27, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28393168/micro-extended-nano-sampling-interface-from-a-living-single-cell
#13
L Lin, K Mawatari, K Morikawa, Y Pihosh, A Yoshizaki, T Kitamori
Single-cell analysis is of increasing importance in many fields, but is challenging due to the ultra-small volumes (picoliters) of single cells. Indeed, analysis of a specific analyte might require the analysis of a single molecule or several molecules. Analytical processes usually include sampling, chemical processing, and detection. Although several papers have reported chemical processing and detection methods for single cells, a sampling method compatible with maintaining the viability of a single cell during sampling has yet to be developed...
April 10, 2017: Analyst
https://www.readbyqxmd.com/read/28388528/porous-nano-structured-micro-granules-from-silica-milk-bi-colloidal-suspension-synthesis-and-characterization
#14
Priyanka Biswas, D Sen, S Mazumder, J S Melo, C B Basak, Kinshuk Dasgupta
Synthesis and characterization of nano-structured porous granules, with fairly defined morphology and porosity, is crucial because such granules are widely utilized for various technological applications. However, an easy, one-step, economic synthesis protocol for large scale production is extremely desirable. In the present work, we have reported the synthesis and characterization of the nano-structured micro-granules using aerosol drying of bi-colloidal suspension of nano-silica and milk. Removal of soft organic component from the granules results in formation of meso and macro pores with moderate specific surface area...
March 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28385265/microfluidic-high-performance-liquid-chromatography-chip-hyphenation-to-inductively-coupled-plasma-mass-spectrometry
#15
David P Bishop, Lucas Blanes, Alexander B Wilson, Thor Wilbanks, Kevin Killeen, Rudolf Grimm, Ross Wenzel, Derek Major, Mirek Macka, David Clarke, Robin Schmid, Nerida Cole, Philip A Doble
The Agilent Chip Cube Interface is a microfluidic chip-based technology originally designed for nanospray molecular mass spectrometry in which the sample enrichment, nano-column, tubing, connectors and spray tip were integrated into a single biocompatible chip. Here we describe the hyphenation of the Chip Cube Interface to ICP-MS via modification of the standard HPLC chip design and a new total consumption nebuliser suitable for flow rates as low as 300nLmin(-1). The potential of the instrument to eliminate common nanoLC - ICP-MS shortcomings such as leaks, blockages and band-broadening was demonstrated via analysis of cyanocobalamin in equine plasma...
March 19, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28380951/near-infrared-spectro-interferometer-using-femtosecond-laser-written-gls-embedded-waveguides-and-nano-scatterers
#16
G Martin, M Bhuyan, J Troles, C D'Amico, R Stoian, E Le Coarer
Guided optics spectrometers can be essentially classified into two main families: based on Fourier transform or dispersion. In the first case, an interferogram generated inside an optical waveguide and containing the spectral information is sampled using spatially distributed nanodetectors. These scatter quasi-non-perturbingly light into the detector that is in contact with the waveguide, helping to reconstruct the stationary wave. A dedicated FFT processing is needed in order to recover the spectrum with high resolution but limited spectral range...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28380950/corrugation-assisted-metal-coated-angled-fiber-facet-for-wavelength-dependent-off-axis-directional-beaming
#17
Hyuntai Kim, Haechan An, Jinseob Kim, Seungsu Lee, Kyoungyoon Park, Seungjong Lee, Seungsoo Hong, Luis Alonso Vazquez-Zuniga, Seung-Yeol Lee, Byoungho Lee, Yoonchan Jeong
We propose a fiber-optic-plasmonic hybrid device that is based on a corrugation-assisted metal-coated angled fiber facet (CA-MCAFF) for wavelength-dependent off-axis directional beaming (WODB). The device breaks into two key structures: One is the MCAFF structure, which is a modified Kretschmann configuration implemented onto a fiber platform, thereby being able to generate a unidirectional surface plasmon with dramatically enhanced properties in terms of non-confined diffracted radiation loss and operational bandwidth...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28376397/a-smartphone-imaging-based-label-free-and-dual-wavelength-fluorescent-biosensor-with-high-sensitivity-and-accuracy
#18
Won-Il Lee, Sajal Shrivastava, Le-Thai Duy, Bo Yeong Kim, Young-Min Son, Nae-Eung Lee
The accuracy of a bioassay based on smartphone-integrated fluorescent biosensors has been limited due to the occurrence of false signals from non-specific reactions as well as a high background and low signal-to-noise ratios for complementary metal oxide semiconductor image sensors. To overcome this problem, we demonstrate dual-wavelength fluorescent detection of biomolecules with high accuracy. Fluorescent intensity can be quantified using dual wavelengths simultaneously, where one decreases and the other increases, as the target analytes bind to the split capture and detection aptamer probes...
March 30, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28374422/a-molecular-propeller-with-three-nanohoop-blades-synthesis-characterization-and-solid-state-packing
#19
Penghao Li, Lev N Zakharov, Ramesh Jasti
Nanoscale carbon-rich molecular architectures are not only aesthetically appealing but also of practical importance for energy and biomedical technologies. Herein, we report the synthesis of cyclic-oligophenylene-based nanopropeller 1 by using an efficient synthon strategy involving sequential intramolecular bisboronate homocoupling and reductive aromatization by H2 SnCl4 . The nanopropeller molecules pack into a layered hexagonal lattice featuring long-ranged nano-sized channels and a total guest-accessible volume of 48 %, as revealed by X-ray diffraction studies...
April 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28371407/biocatalytic-virus-capsid-as-nanovehicle-for-enzymatic-activation-of-tamoxifen-in-tumor-cells
#20
Alejandro Tapia-Moreno, Karla Juarez-Moreno, Oscar Gonzalez-Davis, Ruben D Cadena-Nava, Rafael Vazquez-Duhalt
Most of the drugs used in chemotherapy should be activated by a transformation catalyzed by cytochrome P450 (CYP) enzymes. In this work, bacteriophage P22 virus-like particles (VLPs) containing CYP activity, immunologically inert and functionalized in order to be recognized by human cervix carcinoma cells and human breast adenocarcinoma cells were designed. The CYP was encapsulated inside the virus capsid obtained from the bacteriophage P22. CYP and coat protein were both heterologously expressed in E. coli...
April 3, 2017: Biotechnology Journal
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