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Nano technology

Mostafa Nakach, Jean-René Authelin, Christophe Agut
Stirred media milling is the main technology for producing colloidal nano-crystalline suspensions. A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling tool box that can be used to support candidate from selection up to phase III clinical supplies can involve different mill configurations. This paper describes a parametric study and milling kinetic modelling of the different mills. The impact of active pharmaceutical ingredient (API) type and process parameters on milling kinetics was determined...
March 13, 2017: Journal of Pharmaceutical Sciences
Jun Nozawa, Satoshi Uda, Suxia Guo, Sumeng Hu, Akiko Toyotama, Junpei Yamanaka, Junpei Okada, Haruhiko Koizumi
Understanding nucleation dynamics is important both fundamentally as well as technologically in materials science and other scientific fields. Two-dimensional (2D) nucleation is the predominant growth mechanism in colloidal crystallization, in which the particle interaction is attractive, and has recently been regarded as a promising method to fabricate varieties of complex nano-structures possessing innovative functionality. Here, polymers are added to a colloidal suspension to generate a depletion attractive force, and the detailed 2D nucleation process on the terrace of the colloidal crystals is investigated...
March 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Yujing Song, Pengyu Chen, Meng Ting Chung, Robert Nidetz, Younggeun Park, Zhenhui Liu, Walker McHugh, Timothy T Cornell, Jianping Fu, Katsuo Kurabayashi
Label-free, nanoparticle-based plasmonic optical biosensing, combined with device miniaturization and microarray integration, has emerged as a promising approach for rapid, multiplexed biomolecular analysis. However, limited sensitivity prevents the wide use of such integrated label-free nanoplasmonic biosensors in clinical and life science applications where low-abundance biomolecule detection is needed. Here, we present a nanoplasmofluidic device integrated with microelectrodes for rapid, label-free analysis of a low-abundance cell signaling protein, detected by AC electroosmosis-enhanced localized surface plasmon resonance (ACE-LSPR) biofunctional nanoparticle imaging...
March 17, 2017: Nano Letters
Donato Conteduca, Francesco Dell'Olio, Thomas F Krauss, Caterina Ciminelli
The ability to manipulate and sense biological molecules is important in many life science domains, such as single-molecule biophysics, the development of new drugs and cancer detection. Although the manipulation of biological matter at the nanoscale continues to be a challenge, several types of nanotweezers based on different technologies have recently been demonstrated to address this challenge. In particular, photonic and plasmonic nanotweezers are attracting a strong research effort especially because they are efficient and stable, they offer fast response time, and avoid any direct physical contact with the target object to be trapped, thus preventing its disruption or damage...
March 2017: Applied Spectroscopy
Yuancai Lv, Zhuyu Niu, Yuancai Chen, Yongyou Hu
With the introduction of nano zero valent iron (nZVI) technology into our environment, its potential environmental risk to environmental microorganisms has attracted considerable attention. In this study, Pseudomonas putida was chosen as a typical strain to study the bacterial toxicity of nZVI/Pd. The CFU assay results indicated that nZVI/Pd was toxic to P. putida cells but the toxicity decreased with an increase in DO. The experiments isolated by dialysis bag and flow cytometry analysis suggested that both membrane disruption caused by direct contact and oxidative stress were the main bactericidal mechanisms under the aerobic condition, while membrane disruption resulting from direct contact was the primary bactericidal mechanism in the anaerobic system...
March 6, 2017: Water Research
Bing Liu, Xiao-Ming Shi, Gui-Yong Xiao, Yu-Peng Lu
A scholzite (CaZn2(PO4)2·2H2O) coating was prepared in situ on commercially pure titanium (cpTi) and Ti-6Al-4V (Ti64) substrates using the chemical conversion technology, and its phase composition and microstructure, as well as mechanical, chemical and biological properties were investigated to explore potential applications as a bioactive coating on bone implants. It is indicated that the coating consists mainly of monoclinic scholzite crystals with nano-thick laminar morphology. The crystals on cpTi aggregate to flower-like particles with the diameter of 5-10μm, while form a network structure homogeneously on Ti64...
March 6, 2017: Colloids and Surfaces. B, Biointerfaces
Mohsen Mirzaei, Hossein Khodabakhshi Rafsanjani
Nanoparticles have a wide range of applications in science and technology, and the size distribution of nanoparticles is one of the most important statistical properties. Transmission electron microscopy (TEM) or X-ray diffraction is commonly used for the characterization and measuring particle size distributions, but manual analysis of the micrographs is extremely labor-intensive. Here, we have developed an image processing algorithm for measuring particle size distributions from TEM images in the presence of overlapped particles and uneven background...
February 28, 2017: Micron: the International Research and Review Journal for Microscopy
Jianjun Wei, Zheng Zeng, Yongbin Lin
Here is presented a miniaturized, fiber-optic (FO) nanoprobe biosensor based on the localized surface plasmon resonance (LSPR) at the reusable dielectric-metallic hybrid interface with a robust, gold nano-disk array at the fiber end facet. The nanodisk array is directly fabricated using electron beam lithography (EBL) and metal lift-off process. The free prostate-specific antigen (f-PSA) has been detected with a mouse anti-human prostate-specific antigen (PSA) monoclonal antibody (mAb) as a specific receptor linked with a self-assembled monolayer (SAM) at the LSPR-FO facet surfaces...
2017: Methods in Molecular Biology
Jubayer Jalil, Yong Zhu, Chandima Ekanayake, Yong Ruan
During the last three decades, the remarkable dynamic features of microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS), and advances in solid-state electronics hold much potential for the fabrication of extremely sensitive charge sensors. These sensors have a broad range of applications, such as those involving the measurement of ionization radiation, detection of bio-analyte and aerosol particles, mass spectrometry, scanning tunneling microscopy, and quantum computation. Designing charge sensors (also known as charge electrometers) for electrometry is deemed significant because of the sensitivity and resolution issues in the range of micro- and nano-scales...
April 7, 2017: Nanotechnology
Christian Santschi, Nadia Von Moos, Volodymyr B Koman, Vera I Slaveykova, Paul Bowen, Olivier J F Martin
Engineered nanomaterials (ENMs) are key drivers for the development of highly sophisticated new technologies. As all new attainments, the rapidly increasing used of ENMs raise concerns about their safety for the environment and humans. There is growing evidence showing that if engineered nanomaterials are released into the environment, there is a possibility that they could cause harm to aquatic microorganisms. Among the divers effects triggering their toxicity the ability of ENMs to generate reactive oxygen species (ROS) capable of oxidizing biomolecules is currently considered a central mechanism of toxicity...
March 7, 2017: Journal of Nanobiotechnology
Hongquan Yu, Yue Li, Yang Song, Yanbo Wu, Xijie Lan, Shimin Liu, Yanning Tang, Shasha Xu, Baojiu Chen
Electrospinning has emerged as an attractive technique for the fabrication of ultrafine fibres in micro-/nano-scale fineness: however, it remains a significant technological challenge to assemble aligned fibre arrays via an conventional electrospinning method due to the inherent whipping instability of the polymeric jet. We herein have first developed a simple modified electrospinning method with which to prepare ultralong (>300 mm) well-aligned inorganic fibre arrays, i.e., using an ultrahigh molecular weight polymer to suppress or eliminate the whipping motion of the electrospun jet, has emerged as a facile approach for the continuous fabrication of well-aligned, ultralong fibres through simply using a rotating cylinder as the collector (it was not found necessary to use a very high rotating speed, extra magnetic, electrical field) in the electrospinning process...
March 7, 2017: Scientific Reports
Leonardo Ricotti, Toshinori Fujie
This paper aims to describe the disruptive potential that polymeric thin films have in the field of biohybrid devices and to review the recent efforts in this area. Thin (thickness  <  1 mm) and ultra-thin (thickness  <  1 µm) matrices possess a series of intriguing features, such as large surface area/volume ratio, high flexibility, chemical and physical surface tailorability, etc. This enables the fabrication of advanced bio/non-bio interfaces able to efficiently drive cell-material interactions, which are the key for optimizing biohybrid device performances...
March 6, 2017: Bioinspiration & Biomimetics
Y A V Espinel, F G S Santos, G O Luiz, T P Mayer Alegre, G S Wiederhecker
The simultaneous control of optical and mechanical waves has enabled a range of fundamental and technological breakthroughs, from the demonstration of ultra-stable frequency reference devices, to the exploration of the quantum-classical boundaries in optomechanical laser-cooling experiments. More recently, such an optomechanical interaction has been observed in integrated nano-waveguides and microcavities in the Brillouin regime, where short-wavelength mechanical modes scatter light at several GHz. Here we engineer coupled optical microcavities to enable a low threshold excitation of mechanical travelling-wave modes through backward stimulated Brillouin scattering...
March 6, 2017: Scientific Reports
Sheng-Wen Wang, Kuo-Bin Hong, Yu-Lin Tsai, Chu-Hsiang Teng, An-Jye Tzou, You-Chen Chu, Po-Tsung Lee, Pei-Cheng Ku, Chien-Chung Lin, Hao-Chung Kuo
In this research, nano-ring light-emitting diodes (NRLEDs) with different wall width (120 nm, 80 nm and 40 nm) were fabricated by specialized nano-sphere lithography technology. Through the thinned wall, the effective bandgaps of nano-ring LEDs can be precisely tuned by reducing the strain inside the active region. Photoluminescence (PL) and time-resolved PL measurements indicated the lattice-mismatch induced strain inside the active region was relaxed when the wall width is reduced. Through the simulation, we can understand the strain distribution of active region inside NRLEDs...
March 3, 2017: Scientific Reports
Xing Wang, Xia Wu, Helin Xing, Guilan Zhang, Quan Shi, Lingling E, Na Liu, Tingyuan Yang, Dongsheng Wang, Feng Qi, Lianyan Wang, Hongchen Liu
Insulin is considered as a classical central regulator of energy homeostasis. Recently, the effect of insulin on bone has gained a lot of attentions, but little has been paid to the application in bone tissue engineering. In this study, porous nano-hydroxyapatite/collagen (nHAC) scaffolds incorporating poly lactic-co-glycolic- acid (PLGA) particles were successfully developed as an insulin delivery platform for bone regeneration. Bioactive insulin was successfully released from the PLGA particles within scaffold, and the size of the particles as well as the release kinetics of the insulin could be efficiently controlled through Shirasu porous glass premix membrane emulsification technology...
March 3, 2017: ACS Applied Materials & Interfaces
Bashir Ahmad, Nabia Hafeez, Shumaila Bashir, Abdur Rauf, Mujeeb-Ur-Rehman
In a couple of decades, nanotechnology has become a trending technology owing to its integrated science collection that incorporates variety of fields such as chemistry, physics, medicine, catalytic processes, food processing industries, electronics and energy sectors. One of the emerging fields of nanotechnology that has gained momentous admiration is nano-biotechnology. Nano-biotechnology is an integrated combination of biology with nanotechnology that encompasses the tailoring, and synthesis of small particles that are less than 100nm in size and subsequent exploitation of these particles for their biological applications...
February 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Gaëlle Le Fer, Clémence Le Cœur, Jean-Michel Guigner, Catherine Amiel, Gisèle Volet
Stealth nanocarriers are a promising technology for the treatment of diseases. However, the preparation and characterization of well-defined soft nanoparticulate systems remain challenging. Here we describe a platform of amphiphilic graft copolymers leading to nanoparticles with multiple morphologies and the role of the hydrophilic backbone in their interaction with a model protein. The amphiphilic graft copolymers platform was composed of hydrophilic backbone poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline) (P(MeOx-co-PentOx)), prepared via cationic ring-opening polymerization...
March 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Ivan Prieto, Roksolana Kozak, Oliver Skibitzki, Marta D Rossell, Peter Zaumseil, Giovanni Capellini, Emilio Gini, Karsten Kunze, Yadira Arroyo Rojas Dasilva, Rolf Erni, Thomas Schroeder, Hans von Känel
Nano-heteroepitaxial growth of GaAs on Si(001) by metal organic vapor phase epitaxy was investigated to study emerging materials phenomena on the nano-scale of III-V/Si interaction. Arrays of Si nano-tips (NTs) embedded in a SiO2 matrix were used as substrates. The NTs had top Si openings of 50-90 nm serving as seeds for the selective growth of GaAs nano-crystals (NCs). The structural and morphological properties were investigated by high resolution scanning electron microscopy, atomic force microscopy, electron backscatter diffraction, x-ray diffraction, and high resolution scanning transmission electron microscopy...
February 27, 2017: Nanotechnology
Oliver Skibitzki, Ivan Prieto, Roksolana Kozak, Giovanni Capellini, Peter Zaumseil, Yadira Arroyo Rojas Dasilva, Marta D Rossell, Rolf Erni, Hans von Känel, Thomas Schroeder
We present the nanoheteroepitaxial growth of gallium arsenide (GaAs) on nano-patterned silicon (Si) (001) substrates fabricated using a CMOS technology compatible process. The selective growth of GaAs nano-crystals (NCs) was achieved at 570 °C by MOVPE. A detailed structure and defect characterization study of the grown nano-heterostructures was performed using scanning transmission electron microscopy, x-ray diffraction, micro-Raman, and micro-photoluminescence (μ-PL) spectroscopy. The results show single-crystalline, nearly relaxed GaAs NCs on top of slightly, by the SiO2-mask compressively strained Si nano-tips (NTs)...
February 27, 2017: Nanotechnology
Kan-Sheng Chen, Rui Xu, Norman S Luu, Ethan B Secor, Koichi Hamamoto, Qianqian Li, Soo Kim, Vinod K Sangwan, Itamar Balla, Linda M Guiney, Jung-Woo T Seo, Xiankai Yu, Weiwei Liu, Jinsong Wu, Chris Wolverton, Vinayak P Dravid, Scott A Barnett, Jun Lu, Khalil Amine, Mark C Hersam
Efficient energy storage systems based on lithium-ion batteries represent a critical technology across many sectors including consumer electronics, electrified transportation, and a smart grid accommodating intermittent renewable energy sources. Nanostructured electrode materials present compelling opportunities for high-performance lithium-ion batteries, but inherent problems related to the high surface area to volume ratios at the nanometer-scale have impeded their adoption for commercial applications. Here, we demonstrate a materials and processing platform that realizes high-performance nanostructured lithium manganese oxide (nano-LMO) spinel cathodes with conformal graphene coatings as a conductive additive...
February 27, 2017: Nano Letters
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