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https://www.readbyqxmd.com/read/28722147/surface-isoelectric-focusing-sief-with-carrier-ampholyte-ph-gradient
#1
Zhichao Wang, Cornelius Ivory, Adrienne R Minerick
Isoelectric focusing (IEF) is a powerful tool for amphoteric protein separations because of high sensitivity, bio-compatibility, and reduced complexity compared to chromatography or mechanical separation techniques. IEF miniaturization is attractive because it enables rapid analysis, easier adaptation to point of care applications, and smaller sample demands. However, existing small-scale IEF tools have not yet been able to analyze single protein spots from array libraries, which are ubiquitous in many pharmaceutical discovery and screening protocols...
July 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28721039/top-down-nanofabrication-of-silicon-nanoribbon-field-effect-transistor-si-nr-fet-for-carcinoembryonic-antigen-detection
#2
Zengtao Bao, Jialin Sun, Xiaoqian Zhao, Zengyao Li, Songkui Cui, Qingyang Meng, Ye Zhang, Tong Wang, Yanfeng Jiang
Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top-down approach is proposed and implemented to fulfill a novel silicon nano-ribbon FET, which acts as biomarker sensor for future clinical application...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28719748/low-temperature-fusible-silver-micro-nano-dendrites-based-electrically-conductive-composites-for-next-generation-printed-fuse-links
#3
Rui Yang, Yang Wang, Dang Wu, Yubin Deng, Yingying Luo, Xiaoya Cui, Xuanyu Wang, Zhixue Shu, Cheng Yang
We systematically investigate the long-neglected low-temperature fusing behavior of silver micro/nano-dendrites and demonstrate the feasibility of employing this intriguing property for the printed electronics application, i.e. printed fuse-link. Fuse-link has experienced insignificant changes since they were invented in 1890's. By introducing the silver micro/nano-dendrites based electrically conductive composites (ECCs) as the printed fusible element, coupled with the state-of-the-art printed electronics technology, key performance characteristics of a fuse-link are dramatically improved as compared with the commercially-available counterparts, including expedient fabrication process, lower-available rated current (40% of the minimum value of Littelfuse 467 series fuses), shorter response time (only 3...
July 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28718292/structural-characterization-of-ordered-non-close-packed-functionalized-silica-nanoparticles-on-gold-surfaces
#4
Christian Grunewald, Madlen Schmudde, Christina Graf, Thomas Risse
Nanostructured surfaces play an important role in modern science and technology. In particular, ordered arrangements of nonclose-packed nanoparticles created by self-assembly offer a versatile route to prepare systems, which can be used in various applications such as sensing, plasmonic devices or antireflection coatings. Self-assembly based systems are particularly appealing as preparation is rather simple. The ability of nanoparticle systems to form nonclosed packed monolayers by self-assembly depends on the balance of various energetic contributions in particular the adsorption energy, the lateral barrier for diffusion and the repulsion between particles...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28715308/sniffing-for-cancer-nano-noses-hold-promise-for-detecting-lung-cancer-and-other-diseases
#5
Shannon Fischer
Nearly two decades ago, Hossam Haick was working on a Ph.D. degree in chemical engineering at the Technion Israel Institute of Technology when terrible news hit: his friend and officemate had leukemia. It was Haick's first close encounter with cancer and the physical toll its treatment could wreak on a person. "He's fine now, but it was very difficult to see him suffer," Haick remembers.
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28715178/flexible-and-robust-superomniphobic-surfaces-created-by-localized-photofluidization-of-azopolymer-pillars
#6
Jaeho Choi, Wonhee Jo, Seung Yeol Lee, Yeon Sik Jung, Shin-Hyun Kim, Hee-Tak Kim
Springtails, insects which breathe through their skins, possess mushroom-shaped nanostructures. As doubly re-entrant geometry in the mushroom head enhances the resistance against liquid invasion, the springtails have robust, liquid-free omniphobic skins. Although omniphobic surfaces are promising for various applications, it remains an important challenge to mimic the structural feature of springtails. This paper presents a pragmatic method to create doubly re-entrant nanostructures and robust superomniphobic surfaces by exploiting localized photofluidization of azopolymers...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28714982/dynamic-surface-self-reconstruction-is-the-key-of-highly-active-perovskite-nano-electrocatalysts-for-water-splitting
#7
Emiliana Fabbri, Maarten Nachtegaal, Tobias Binninger, Xi Cheng, Bae-Jung Kim, Julien Durst, Francesco Bozza, Thomas Graule, Robin Schäublin, Luke Wiles, Morgan Pertoso, Nemanja Danilovic, Katherine E Ayers, Thomas J Schmidt
The growing need to store increasing amounts of renewable energy has recently triggered substantial R&D efforts towards efficient and stable water electrolysis technologies. The oxygen evolution reaction (OER) occurring at the electrolyser anode is central to the development of a clean, reliable and emission-free hydrogen economy. The development of robust and highly active anode materials for OER is therefore a great challenge and has been the main focus of research. Among potential candidates, perovskites have emerged as promising OER electrocatalysts...
July 17, 2017: Nature Materials
https://www.readbyqxmd.com/read/28714408/biomaterials-and-supercritical-fluid-technologies-which-perspectives-to-fabricate-artificial-extracellular-matrix
#8
Della Porta Giovanna, E Reverchon, N Maffulli
The foundation of tissue engineering for either therapeutic or diagnostic applications is the ability to exploit living cells. Tissue engineering utilizes living cells as engineering materials implanted, seeded or bio-plotted into an artificial structure capable of supporting three-dimensional tissue formation. These structures, typically called scaffolds, are critical, both ex vivo and in vivo, to influence their own microenvironments. Scaffolds can serve the following purposes: allow cell attachment and migration, deliver and retain cells and biochemical factors, enable diffusion of vital cell nutrients or expressed products, exert certain mechanical and biological influences to modify the behaviour of the cell phase...
July 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28710644/non-electrolytic-microelectroporation
#9
Chenang Lyu, Jianping Wang, Boris Rubinsky
Micro and nano technologies are of increasing importance in microfluidics devices used for electroporation (electroporation - the permeabilization of the cell membrane with brief high electric field pulses). Electrochemical reactions of electrolysis occur whenever an electric current flows between an electrode and an ionic solution. It can have substantial detrimental effects, both on the cells and solutions during the electroporation. As electrolysis is a surface phenomenon, between electrodes and solution, the extent of electrolysis is increased in micro and nano electroporation over macro-electroporation, because the surface area of the electrodes in micro and nano electroporation is much larger...
September 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28709034/a-bioactive-coating-with-submicron-sized-titania-crystallites-fabricated-by-induction-heating-of-titanium-after-tensile-deformations
#10
Ning-Bo Li, Wen-Hua Xu, Gui-Yong Xiao, Jun-Han Zhao, Yu-Peng Lu
Thermal oxidation technology was widely investigated as one of effective surface modification method for improving the bioactivity and biocompatibility of titanium and its alloys. In this work, the induction heat oxidization method, a fast, efficient, economical and environmental protective technology, was applied to prepare the submicron-morphological oxide coating with variable rutile TiO2 equiaxed crystallites on the surface of pure Ti substrates after cold-drawing with 10-20% deformations. The results showed the plastic-deformed Ti cylinders recrystallized during induction heating treatment (IHT) for 10-20s which resulted in evolution of microstructures as well as slight improvement of microhardness...
July 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28709016/spray-drying-assisted-reassembly-of-uniform-and-large-micro-sized-mil-101-microparticles-with-controllable-morphologies-for-benzene-adsorption
#11
Aijian Zhang, Xin-Yu Li, Shengyu Zhang, Zhikai Yu, Xingmin Gao, Xiangru Wei, Zhangxiong Wu, Winston Duo Wu, Xiao Dong Chen
Significant research has been focused on the synthesis of metal-organic frameworks (MOFs) with controllable compositions and structures, while much fewer works have been devoted to the construction of large micro-sized MOFs with uniform sizes and morphologies, which could be beneficial for practical applications. In this paper, a unique microfluidic jet spray drying technology has been adopted to reassemble nano-sized MIL-101 building blocks into hierarchical microparticles with uniform and large particle sizes...
July 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28702661/clinically-approved-pegylated-nanoparticles-are-covered-by-a-protein-corona-that-boosts-the-uptake-by-cancer-cells
#12
M Papi, D Caputo, V Palmieri, R Coppola, S Palchetti, F Bugli, C Martini, L Digiacomo, D Pozzi, G Caracciolo
Today, liposomes are an advanced technology of drug carriers with a dozen drugs in clinical practice and many more in clinical trials. A bottleneck associated with the clinical translation of liposomes has long been 'opsonization', i.e. the adsorption of plasma proteins at the liposome surface resulting in their rapid clearance from circulation. For decades, the most popular way to avoid opsonization has been grafting polyethylene glycol (PEG) onto the liposome surface. Recent studies have clarified that grafting PEG onto the liposome surface reduces, but does not completely prevent protein binding...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28702558/high-performance-transparent-in-plane-silicon-nanowire-fin-tfts-via-a-robust-nano-droplet-scanning-crystallization-dynamics
#13
Mingkun Xu, Jimmy Wang, Zhaoguo Xue, Junzhuan Wang, Ping Feng, Linwei Yu, Jun Xu, Yi Shi, Kunji Chen, Pere Roca I Cabarrocas
High mobility, scalable and even transparent thin-film transistors (TFTs) are always being pursued in the field of large area electronics. While excimer laser-beam-scanning can crystallize amorphous Si (a-Si) into high mobility poly-Si, it is limited to small areas. We here demonstrate a robust nano-droplet-scanning strategy that converts an a-Si:H thin film directly into periodic poly-Si nano-channels, with the aid of well-coordinated indium droplets. This enables the robust batch-fabrication of high performance Fin-TFTs with a high hole mobility of >100 cm(2) V(-1) s(-1) and an excellent subthreshold swing of only 163 mV dec(-1), via a low temperature <350 °C thin film process...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28701743/precise-detection-of-circular-dichroism-in-a-cluster-of-nano-helices-by-photoacoustic-measurements
#14
Alessio Benedetti, Badrul Alam, Marco Esposito, Vittorianna Tasco, Grigore Leahu, Alessandro Belardini, Roberto Li Voti, Adriana Passaseo, Concita Sibilia
Compact samples of nano-helices built by means of a focused ion beam technology with large bandwidth and high dichroism for circular polarization are promising for the construction of built-in-chip sensors, where the ideal transducer must be sufficiently confined without compromising its filtering ability. Direct all-optical measurements revealed the sample's dichroic character with insufficient details because of scattering and diffraction interference. On the other hand, photoacoustic measurements resulted to be a possible alternative investigation, since they directly deal with absorbed power and allow to get clear evidences of the differential selection for the two opposite polarization states...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698654/megapixel-multi-elemental-imaging-by-laser-induced-breakdown-spectroscopy-a-technology-with-considerable-potential-for-paleoclimate-studies
#15
J O Cáceres, F Pelascini, V Motto-Ros, S Moncayo, F Trichard, G Panczer, A Marín-Roldán, J A Cruz, I Coronado, J Martín-Chivelet
Paleoclimate studies play a crucial role in understanding past and future climates and their environmental impacts. Current methodologies for performing highly sensitive elemental analysis at micrometre spatial resolutions are restricted to the use of complex and/or not easily applied techniques, such as synchrotron radiation X-ray fluorescence micro-analysis (μ-SRXRF), nano secondary ion mass spectrometry (nano-SIMS) or laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Moreover, the analysis of large samples (>few cm²) with any of these methods remains very challenging due to their relatively low acquisition speed (~1-10 Hz), and because they must be operated in vacuum or controlled atmosphere...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694026/nano-technology-based-carriers-for-nitrogen-containing-bisphosphonates-delivery-as-sensitisers-of-%C3%AE-%C3%AE-t-cells-for-anticancer-immunotherapy
#16
Naomi O Hodgins, Julie Tzu-Wen Wang, Khuloud T Al-Jamal
Nitrogen containing bisphosphonates (N-BPs) including zoledronate (ZOL) and alendronate (ALD) inhibit farnesyl diphosphate synthase, and have been shown to have a cytotoxic affect against cancer cells as a monotherapy and to also sensitise tumour cells to destruction by γδ T cells. γδ T cells are a subset of human T lymphocytes and have a diverse range of roles in the immune system including the recognition and destruction of cancer cells. This property of γδ T cells can be harnessed for use in cancer immunotherapy through in vivo expansion or the adoptive transfer of ex vivo activated γδ T cells...
July 7, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28692426/single-crystalline-zno-radial-homojunction-light-emitting-diodes-fabricated-by-metalorganic-chemical-vapour-deposition
#17
Jinkyoung Yoo, Towfiq Ahmed, Wei Tang, Yong-Jin Kim, Young Joon Hong, Chul-Ho Lee, Gyu-Chul Yi
ZnO radial p-n junction architecture has the potential for forward-leap of light-emitting diode technology in terms of higher efficacy and economical production. We report on ZnO radial p-n junction-based light emitting diodes prepared by full metalorganic chemical vapour deposition (MOCVD) with hydrogen-assisted p-type doping approach. The p-type ZnO(P) thin films were prepared by MOCVD with the precursors of dimethylzinc, tert-butanol, and tertiarybutylphosphine. Controlling the precursor flow for dopant results in systematic change of doping concentration, Hall mobility, and electrical conductivity...
July 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28690099/electrospun-polymeric-nanofibers-new-horizons-in-drug-delivery
#18
REVIEW
Shreya Thakkar, Manju Misra
Nanofibers obtained using electrospinning technique are being used since ages especially in fields of textile industry, sensors, filters, protective clothing and tissue engineering. Their use as drug delivery system is an emerging platform in the field of pharmaceuticals and now-a-days formulation scientists are paying great attention to the technology due to several advantages prime being easy modulation of drug release profile depending upon the properties of polymer/polymeric blends/other materials used...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28684661/strategies-for-the-afm-based-manipulation-of-silver-nanowires-on-a-flat-surface
#19
Hongzhi Liu, Sen Wu, Junming Zhang, Huitian Bai, Fan Jin, Hai Pang, Xiaodong Hu
Silver nanowires (Ag NWs) are promising material for building various sensors and devices at nanoscale. However, fast and precise placement of individual Ag NWs is still a challenge today. Atomic force microscopy (AFM) has been widely used to manipulate nanoparticles, yet this technology meets many difficulties when being applied to move Ag NWs as well as other soft one-dimensional (1D) materials, since these samples are easily distorted or even broken due to the frictions and adhesion on the substrate. In this paper, two novel manipulation strategies based on parallel pushing method are presented...
July 7, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28682331/three-dimensional-integration-of-nanotechnologies-for-computing-and-data-storage-on-a-single-chip
#20
Max M Shulaker, Gage Hills, Rebecca S Park, Roger T Howe, Krishna Saraswat, H-S Philip Wong, Subhasish Mitra
The computing demands of future data-intensive applications will greatly exceed the capabilities of current electronics, and are unlikely to be met by isolated improvements in transistors, data storage technologies or integrated circuit architectures alone. Instead, transformative nanosystems, which use new nanotechnologies to simultaneously realize improved devices and new integrated circuit architectures, are required. Here we present a prototype of such a transformative nanosystem. It consists of more than one million resistive random-access memory cells and more than two million carbon-nanotube field-effect transistors-promising new nanotechnologies for use in energy-efficient digital logic circuits and for dense data storage-fabricated on vertically stacked layers in a single chip...
July 5, 2017: Nature
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