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R Glenn Gaston, John W Bracey, Mark A Tait, Bryan J Loeffler
Control of independent digital flexion and extension has remained an elusive goal in myoelectric prosthetics for upper extremity amputees. We first performed a cadaver study to determine the feasibility of transferring the interossei muscles for each digit to the dorsum of the hand without damaging the neurovascular pedicles. Once this capability was ensured, a clinical case was performed transferring the interossei of the middle and ring fingers to the dorsum of the hand where they could serve as a myoelectric signal for a partial hand amputee to allow individual digital control with a myoelectric prosthesis...
June 13, 2018: Journal of Hand Surgery
S Khochtali, M Zayani, I Ksiaa, I Ben Meriem, S Zaouali, B Jelliti, M Khairallah
BACKGROUND: Idiopathic orbital inflammatory syndrome (IOIS) is an inflammatory condition of unknown etiology. The inflammation may affect all the structures within the orbit (anterior, diffuse, apical, myositic, dacryoadenitis) and corresponds to uniquely orbital inflammation without an identifiable local cause or systemic disease. The goal of this study is to describe the clinical and radiographic characteristics of IOIS and discuss the role of orbital biopsy in this condition. PATIENTS AND METHODS: This is a retrospective review of the charts of 24 patients diagnosed with IOIS at Fattouma Bourguiba hospital, Monastir, Tunisia, from January 2007 to December 2015...
April 2018: Journal Français D'ophtalmologie
S Abad, F Héran, C Terrada, P Bielefeld, D Sène, S Trad, D Saadoun, P Sève
Inflammatory orbitopathies relate to an inflammatory state originating within the orbit and its adnexes, except the inner ocular globe. Orbital inflammation (OI) may be either localized manifestation of a proven or like autoimmune disease, or local response from immune system against infectious, structural or tumoral antigens. We review the clinical manifestations of OI, which provide helpful clues to the diagnosis and describe the inflammatory, infectious and neoplastic conditions classically associated with OI...
February 1, 2018: La Revue de Médecine Interne
L Szenborn, K Toczek-Kubicka, J Zaryczański, M Marchewka-Kowalik, K Miśkiewicz, E Kuchar
Benign acute childhood myositis (BACM) is a syndrome classically occurring in children during the convalescent phase from a febrile upper respiratory tract infection, most commonly after influenza B. BACM can cause difficulty walking due to severe calf pain. Laboratory results show increased serum creatinine kinase and AST. Although alarming, BACM is self-limiting with symptoms disappearing within a week. Herein, we described a case series of BCAM in children in two cities in Poland during the influenza outbreaks in 2012/2013 and 2014/2015...
2018: Advances in Experimental Medicine and Biology
Ilse Mombaerts, Jurij R Bilyk, Geoffrey E Rose, Alan A McNab, Aaron Fay, Peter J Dolman, Richard C Allen, Martin H Devoto, Gerald J Harris
Importance: Current practice to diagnose idiopathic orbital inflammation (IOI) is inconsistent, leading to frequent misdiagnosis of other orbital entities, including cancer. By specifying criteria, diagnosis of orbital inflammation will be improved. Objective: To define a set of criteria specific for the diagnosis of IOI. Design, Setting, and Participants: A 3-round modified Delphi process with an expert panel was conducted from June 8, 2015, to January 25, 2016...
July 1, 2017: JAMA Ophthalmology
Andreas Reinke, Michael Kraus, Alexander Wild
Background Myosits ossificans (MO) is a rare but important differential diagnosis for a heterotrophic bony tumor in the muscles. It is often misdiagnosed as a malignant tumor. With a previous trauma the diagnosis is myositis ossificans traumatic (MOT). In most cases, it is benign and predominantly seen in the big muscles. But there can be malignant etiologies too. Case Description We report a rare case of MO in the muscle of the craniocervical junction. This 37-year-old woman had a riding accident years ago...
June 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
Derar Derar, Ahmed Ali, Mohamed Tharwat, Fahd Al-Sobayil, Moustafa M Zeitoun
This study aimed to clarify the phenomenon of erectile dysfunction (ED) in male camels and monitor the associated changes in nitric oxide metabolite (NOM), cardiac troponin I (cTnI), and testosterone concentrations. A total 18 camels with ED and 10 controls were included in this study. The breeding history was recorded and a thorough breeding soundness examination was performed. Total nitrates and nitrites were determined in sera using the Griess assay. Serum cTnI and testosterone were assessed using ELISA...
February 2017: Theriogenology
N G Margraf, A Wrede, G Deuschl, W J Schulz-Schaeffer
Camptocormia is a disabling pathological, non-fixed, forward bending of the trunk. The clinical definition using only the bending angle is insufficient; it should include the subjectively perceived inability to stand upright, occurrence of back pain, typical individual complaints, and need for walking aids and compensatory signs (e.g. back-swept wing sign). Due to the heterogeneous etiologies of camptocormia a broad diagnostic approach is necessary. Camptocormia is most frequently encountered in movement disorders (PD and dystonia) and muscles diseases (myositis and myopathy, mainly facio-scapulo-humeral muscular dystrophy (FSHD))...
June 16, 2016: Journal of Parkinson's Disease
Stephanie M Young, Anita S Y Chan, Issam Al Jajeh, Sunny Shen, Lay-Leng Seah, Chai-Teck Choo, Stephanie S Lang, Audrey L G Looi
PURPOSE: 1) To assess the clinical profile and treatment outcomes of orbital inflammatory disease in the local population, and 2) classify patients using current histopathological criteria. METHODS: Ten-year retrospective clinicopathologic review of patients diagnosed with orbital inflammatory disease who underwent tissue biopsy from January 2001 to December 2011 at a tertiary referral centre in Singapore. Data collection included patient demographics, clinical presentation, investigations, systemic disease, histopathology review, clinical classification, medical and surgical management, response to treatment and recurrence rates...
May 2017: Ophthalmic Plastic and Reconstructive Surgery
Dennis Tappe, Günther Slesak, José Vicente Pérez-Girón, Johannes Schäfer, Andreas Langeheinecke, Gudrun Just-Nübling, César Muñoz-Fontela, Kerstin Püllmann
Sarcocystis nesbitti is a parasite responsible for a biphasic eosinophilic febrile myositis syndrome in two recent outbreaks in Malaysia. We demonstrate Th2 cytokine polarization in infected travelers, an overall cytokine production decrease in the early phase of the disease suggestive of initial immunosuppression, and elevated levels of proinflammatory and chemotactic cytokines in the later myositic phase.
June 2015: Clinical and Vaccine Immunology: CVI
Naoko Okiyama, Hisanori Hasegawa, Takatoku Oida, Shinya Hirata, Hiroo Yokozeki, Manabu Fujimoto, Nobuyuki Miyasaka, Hitoshi Kohsaka
It is suggested that polymyositis, an autoimmune inflammatory myopathy, is mediated by autoaggressive CD8 T cells. Skeletal muscle C protein is a self-antigen that induces C protein-induced myositis, a murine model of polymyositis. To establish a new murine model of myositis inducible with a single CD8 T-cell epitope peptide that derives from the C protein, three internet-based prediction systems were employed to identify 24 candidate peptides of the immunogenic fragment of the C protein and bind theoretically to major histocompatibility complex class I molecules of C57BL/6 (B6) mice...
July 2015: International Immunology
B Kanthimathi, S Udhaya Shankar, K Arun Kumar, V L Narayanan
Myositis ossificans traumatica is an unusual complication following a muscle contusion injury. A significantly large myositic mass causing ankylosis of the elbow is even rarer. We report a 13-year-old boy who presented with a 14-month history of a fixed elbow with no movement and a palpable bony mass in the anterior aspect of the elbow. He had sustained significant trauma to the affected limb 1 month prior to onset of symptoms, which was managed by native massage and bandaging for 4 weeks. The clinicoradiological diagnosis was suggestive of myositis ossificans, and the myositic mass was completely excised...
December 2014: Clinics in Orthopedic Surgery
Michael O Harris-Love, Galen Joe, Todd E Davenport, Deloris Koziol, Kristen Abbett Rose, Joseph A Shrader, Olavo M Vasconcelos, Beverly McElroy, Marinos C Dalakas
OBJECTIVE: The Adult Myopathy Assessment Tool (AMAT) is a 13-item performance-based battery developed to assess functional status and muscle endurance. The purpose of this study was to determine the intrarater and interrater reliability of the AMAT in adults with myositis. METHODS: Nineteen raters (13 physical therapists and 6 physicians) scored videotaped recordings of patients with myositis performing the AMAT for a total of 114 tests and 1,482 item observations per session...
April 2015: Arthritis Care & Research
Josko Mitrovic, Zeljko Prka, Rado Zic, Srecko Marusic, Jadranka Morovic-Vergles
Focal myositis is a rare, mostly benign disease (pseudotumor) of skeletal muscle, histopathologically characterized by interstitial myositis and tumorous enlargement of a single muscle. The etiology of focal myositis remains unknown; however, localized myopathy has been postulated to be caused by denervation lesions. This case report describes a patient that presented with clinical, laboratory, electromyoneurography, and magnetic resonance imaging features of focal myositis complicated with intervertebral disk protrusion in the lumbosacral spine affected with radicular distress...
March 2014: Clinical Neuropharmacology
Kenneth M Peters, Roger R Dmochowski, Lesley K Carr, Magali Robert, Melissa R Kaufman, Larry T Sirls, Sender Herschorn, Colin Birch, Patricia L Kultgen, Michael B Chancellor
PURPOSE: We assess the 12-month safety and potential efficacy of autologous muscle derived cells for urinary sphincter repair (Cook MyoSite Incorporated, Pittsburgh, Pennsylvania) in women with stress urinary incontinence. MATERIALS AND METHODS: Pooled data from 2 phase I/II studies with identical patient selection criteria and outcome measures were analyzed. Enrolled patients had stress urinary incontinence refractory to prior treatment and no symptom improvement during the last 6 months...
August 2014: Journal of Urology
Robert W Georgantas, Katie Streicher, Steven A Greenberg, Lydia Greenlees, Wei Zhu, Philip Brohawn, Brandon W Higgs, Meggan Czapiga, Chris Morehouse, Anthony Amato, Laura Richman, Bahija Jallal, Yihong Yao, Koustubh Ranade
Objective: The molecular basis of inflammatory myopathies such as dermatomyositis, polymyositis, and inclusion body myositis, which share the characteristics of chronic muscle inflammation and skeletal muscle wasting, are poorly understood. As such, effective targeted treatments for these diseases are lacking, resulting in critical unmet medical needs for these devastating diseases. In order to identify possible new targets for drug development, this study explored the mechanism by which inflammation may play a role in inflammatory myopathy pathology...
November 27, 2013: Arthritis and Rheumatism
Sree Rayavarapu, William Coley, Jack H Van der Meulen, Erdinc Cakir, Kathyayini Tappeta, Travis B Kinder, Blythe C Dillingham, Kristy J Brown, Yetrib Hathout, Kanneboyina Nagaraju
OBJECTIVE: Myositis is characterized by severe muscle weakness. We and others have previously shown that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of myositis. The present study was undertaken to identify perturbed pathways and assess their contribution to muscle disease in a mouse myositis model. METHODS: Stable isotope labeling with amino acids in cell culture (SILAC) was used to identify alterations in the skeletal muscle proteome of myositic mice in vivo...
December 2013: Arthritis and Rheumatism
Lesley K Carr, Magali Robert, Patricia L Kultgen, Sender Herschorn, Colin Birch, Magnus Murphy, Michael B Chancellor
PURPOSE: In this feasibility study we assessed the 12-month safety and potential efficacy of autologous muscle derived cells (Cook MyoSite Incorporated, Pittsburgh, Pennsylvania) as therapy for stress urinary incontinence. MATERIALS AND METHODS: A total of 38 women in whom stress urinary incontinence had not improved with conservative therapy for 12 or more months underwent intrasphincter injection of low doses (1, 2, 4, 8 or 16 × 10(6)) or high doses (32, 64 or 128 × 10(6)) of autologous muscle derived cells, which were derived from biopsies of their quadriceps femoris...
February 2013: Journal of Urology
Hanna Gendek-Kubiak, Ewa G Gendek
OBJECTIVE: Dendritic cells (DC) have been reported among inflammatory infiltrating cells in muscle tissue in idiopathic inflammatory myopathies (IIM), but to our knowledge no studies concerning the expression of langerin (CD207) or fascin (markers of immature and mature DC, respectively) in IIM have been published. METHODS: Immunohistochemical analyses of langerin and fascin expression were performed on specimens from normal muscles, as well as those affected by polymyositis (PM) and dermatomyositis (DM)...
February 2013: Journal of Rheumatology
Flavio H F Galvao, Wangles Soler, Eduardo Pompeu, Daniel R Waisberg, Evandro S D Mello, Anderson C L Costa, Walcy Teodoro, Ana P Velosa, Vera L Capelozzi, Leila Antonangelo, Sergio Catanozi, Alessandro Martins, Luiz M S Malbouisson, Ruy J Cruz, Estela R Figueira, Joel A R Filho, Eleazar Chaib, Luiz A C D'Albuquerque
INTRODUCTION: Xenotransplantation is a potential solution for the high mortality of patients on the waiting list for multivisceral transplantation; nevertheless, hyperacute rejection (HAR) hampers this practice and motivates innovative research. In this report, we describe a model of multivisceral xenotransplantation in which we observed immunoglobulin G (IgG) involvement in HAR. METHODS: We recovered en bloc multivisceral grafts (distal esophagus, stomach, small intestine, colon, liver, pancreas, and kidneys) from rabbits (n = 20) and implanted them in the swine (n = 15) or rabbits (n = 5, control)...
September 2012: Xenotransplantation
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