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https://www.readbyqxmd.com/read/27314757/pathophysiological-concepts-and-treatment-of-camptocormia
#1
N G Margraf, A Wrede, G Deuschl, W J Schulz-Schaeffer
Camptocormia is a disabling pathological, non-fixed, forward bending of the trunk. The clinical definition using only the bending angle is insufficient; it should include the subjectively perceived inability to stand upright, occurrence of back pain, typical individual complaints, and need for walking aids and compensatory signs (e.g. back-swept wing sign). Due to the heterogeneous etiologies of camptocormia a broad diagnostic approach is necessary. Camptocormia is most frequently encountered in movement disorders (PD and dystonia) and muscles diseases (myositis and myopathy, mainly facio-scapulo-humeral muscular dystrophy (FSHD))...
June 16, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27097061/clinical-features-and-treatment-outcomes-of-orbital-inflammatory-disease-in-singapore-a-10-year-clinicopathologic-review
#2
Stephanie M Young, Anita S Y Chan, Issam Al Jajeh, Sunny Shen, Lay-Leng Seah, Chai-Teck Choo, Stephanie S Lang, Audrey L G Looi
PURPOSE: 1) To assess the clinical profile and treatment outcomes of orbital inflammatory disease in the local population, and 2) classify patients using current histopathological criteria. METHODS: Ten-year retrospective clinicopathologic review of patients diagnosed with orbital inflammatory disease who underwent tissue biopsy from January 2001 to December 2011 at a tertiary referral centre in Singapore. Data collection included patient demographics, clinical presentation, investigations, systemic disease, histopathology review, clinical classification, medical and surgical management, response to treatment and recurrence rates...
April 19, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/25903356/human-invasive-muscular-sarcocystosis-induces-th2-cytokine-polarization-and-biphasic-cytokine-changes-based-on-an-investigation-among-travelers-returning-from-tioman-island-malaysia
#3
Dennis Tappe, Günther Slesak, José Vicente Pérez-Girón, Johannes Schäfer, Andreas Langeheinecke, Gudrun Just-Nübling, César Muñoz-Fontela, Kerstin Püllmann
Sarcocystis nesbitti is a parasite responsible for a biphasic eosinophilic febrile myositis syndrome in two recent outbreaks in Malaysia. We demonstrate Th2 cytokine polarization in infected travelers, an overall cytokine production decrease in the early phase of the disease suggestive of initial immunosuppression, and elevated levels of proinflammatory and chemotactic cytokines in the later myositic phase.
June 2015: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/25577193/experimental-myositis-inducible-with-transfer-of-dendritic-cells-presenting-a-skeletal-muscle-c-protein-derived-cd8-epitope-peptide
#4
Naoko Okiyama, Hisanori Hasegawa, Takatoku Oida, Shinya Hirata, Hiroo Yokozeki, Manabu Fujimoto, Nobuyuki Miyasaka, Hitoshi Kohsaka
It is suggested that polymyositis, an autoimmune inflammatory myopathy, is mediated by autoaggressive CD8 T cells. Skeletal muscle C protein is a self-antigen that induces C protein-induced myositis, a murine model of polymyositis. To establish a new murine model of myositis inducible with a single CD8 T-cell epitope peptide that derives from the C protein, three internet-based prediction systems were employed to identify 24 candidate peptides of the immunogenic fragment of the C protein and bind theoretically to major histocompatibility complex class I molecules of C57BL/6 (B6) mice...
July 2015: International Immunology
https://www.readbyqxmd.com/read/25436075/myositis-ossificans-traumatica-causing-ankylosis-of-the-elbow
#5
B Kanthimathi, S Udhaya Shankar, K Arun Kumar, V L Narayanan
Myositis ossificans traumatica is an unusual complication following a muscle contusion injury. A significantly large myositic mass causing ankylosis of the elbow is even rarer. We report a 13-year-old boy who presented with a 14-month history of a fixed elbow with no movement and a palpable bony mass in the anterior aspect of the elbow. He had sustained significant trauma to the affected limb 1 month prior to onset of symptoms, which was managed by native massage and bandaging for 4 weeks. The clinicoradiological diagnosis was suggestive of myositis ossificans, and the myositic mass was completely excised...
December 2014: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/25201624/reliability-of-the-adult-myopathy-assessment-tool-in-individuals-with-myositis
#6
Michael O Harris-Love, Galen Joe, Todd E Davenport, Deloris Koziol, Kristen Abbett Rose, Joseph A Shrader, Olavo M Vasconcelos, Beverly McElroy, Marinos C Dalakas
OBJECTIVE: The Adult Myopathy Assessment Tool (AMAT) is a 13-item performance-based battery developed to assess functional status and muscle endurance. The purpose of this study was to determine the intrarater and interrater reliability of the AMAT in adults with myositis. METHODS: Nineteen raters (13 physical therapists and 6 physicians) scored videotaped recordings of patients with myositis performing the AMAT for a total of 114 tests and 1,482 item observations per session...
April 2015: Arthritis Care & Research
https://www.readbyqxmd.com/read/24614669/focal-myositis-of-lower-extremity-responsive-to-botulinum-a-toxin
#7
Josko Mitrovic, Zeljko Prka, Rado Zic, Srecko Marusic, Jadranka Morovic-Vergles
Focal myositis is a rare, mostly benign disease (pseudotumor) of skeletal muscle, histopathologically characterized by interstitial myositis and tumorous enlargement of a single muscle. The etiology of focal myositis remains unknown; however, localized myopathy has been postulated to be caused by denervation lesions. This case report describes a patient that presented with clinical, laboratory, electromyoneurography, and magnetic resonance imaging features of focal myositis complicated with intervertebral disk protrusion in the lumbosacral spine affected with radicular distress...
March 2014: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/24582537/autologous-muscle-derived-cells-for-treatment-of-stress-urinary-incontinence-in-women
#8
Kenneth M Peters, Roger R Dmochowski, Lesley K Carr, Magali Robert, Melissa R Kaufman, Larry T Sirls, Sender Herschorn, Colin Birch, Patricia L Kultgen, Michael B Chancellor
PURPOSE: We assess the 12-month safety and potential efficacy of autologous muscle derived cells for urinary sphincter repair (Cook MyoSite Incorporated, Pittsburgh, Pennsylvania) in women with stress urinary incontinence. MATERIALS AND METHODS: Pooled data from 2 phase I/II studies with identical patient selection criteria and outcome measures were analyzed. Enrolled patients had stress urinary incontinence refractory to prior treatment and no symptom improvement during the last 6 months...
August 2014: Journal of Urology
https://www.readbyqxmd.com/read/24285212/inhibition-of-myogenic-micrornas-1-133-and-206-by-inflammatory-cytokines-links-inflammation-and-muscle-degeneration-in-adult-inflammatory-myopathies
#9
Robert W Georgantas, Katie Streicher, Steven A Greenberg, Lydia Greenlees, Wei Zhu, Philip Brohawn, Brandon W Higgs, Meggan Czapiga, Chris Morehouse, Anthony Amato, Laura Richman, Bahija Jallal, Yihong Yao, Koustubh Ranade
Objective: The molecular basis of inflammatory myopathies such as dermatomyositis, polymyositis, and inclusion body myositis, which share the characteristics of chronic muscle inflammation and skeletal muscle wasting, are poorly understood. As such, effective targeted treatments for these diseases are lacking, resulting in critical unmet medical needs for these devastating diseases. In order to identify possible new targets for drug development, this study explored the mechanism by which inflammation may play a role in inflammatory myopathy pathology...
November 27, 2013: Arthritis and Rheumatism
https://www.readbyqxmd.com/read/24022788/activation-of-the-ubiquitin-proteasome-pathway-in-a-mouse-model-of-inflammatory-myopathy-a-potential-therapeutic-target
#10
Sree Rayavarapu, William Coley, Jack H Van der Meulen, Erdinc Cakir, Kathyayini Tappeta, Travis B Kinder, Blythe C Dillingham, Kristy J Brown, Yetrib Hathout, Kanneboyina Nagaraju
OBJECTIVE: Myositis is characterized by severe muscle weakness. We and others have previously shown that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of myositis. The present study was undertaken to identify perturbed pathways and assess their contribution to muscle disease in a mouse myositis model. METHODS: Stable isotope labeling with amino acids in cell culture (SILAC) was used to identify alterations in the skeletal muscle proteome of myositic mice in vivo...
December 2013: Arthritis and Rheumatism
https://www.readbyqxmd.com/read/23260547/autologous-muscle-derived-cell-therapy-for-stress-urinary-incontinence-a-prospective-dose-ranging-study
#11
RANDOMIZED CONTROLLED TRIAL
Lesley K Carr, Magali Robert, Patricia L Kultgen, Sender Herschorn, Colin Birch, Magnus Murphy, Michael B Chancellor
PURPOSE: In this feasibility study we assessed the 12-month safety and potential efficacy of autologous muscle derived cells (Cook MyoSite Incorporated, Pittsburgh, Pennsylvania) as therapy for stress urinary incontinence. MATERIALS AND METHODS: A total of 38 women in whom stress urinary incontinence had not improved with conservative therapy for 12 or more months underwent intrasphincter injection of low doses (1, 2, 4, 8 or 16 × 10(6)) or high doses (32, 64 or 128 × 10(6)) of autologous muscle derived cells, which were derived from biopsies of their quadriceps femoris...
February 2013: Journal of Urology
https://www.readbyqxmd.com/read/23118112/fascin-expressing-dendritic-cells-dominate-in-polymyositis-and-dermatomyositis
#12
Hanna Gendek-Kubiak, Ewa G Gendek
OBJECTIVE: Dendritic cells (DC) have been reported among inflammatory infiltrating cells in muscle tissue in idiopathic inflammatory myopathies (IIM), but to our knowledge no studies concerning the expression of langerin (CD207) or fascin (markers of immature and mature DC, respectively) in IIM have been published. METHODS: Immunohistochemical analyses of langerin and fascin expression were performed on specimens from normal muscles, as well as those affected by polymyositis (PM) and dermatomyositis (DM)...
February 2013: Journal of Rheumatology
https://www.readbyqxmd.com/read/22957972/immunoglobulin-g-profile-in-hyperacute-rejection-after-multivisceral-xenotransplantation
#13
Flavio H F Galvao, Wangles Soler, Eduardo Pompeu, Daniel R Waisberg, Evandro S D Mello, Anderson C L Costa, Walcy Teodoro, Ana P Velosa, Vera L Capelozzi, Leila Antonangelo, Sergio Catanozi, Alessandro Martins, Luiz M S Malbouisson, Ruy J Cruz, Estela R Figueira, Joel A R Filho, Eleazar Chaib, Luiz A C D'Albuquerque
INTRODUCTION: Xenotransplantation is a potential solution for the high mortality of patients on the waiting list for multivisceral transplantation; nevertheless, hyperacute rejection (HAR) hampers this practice and motivates innovative research. In this report, we describe a model of multivisceral xenotransplantation in which we observed immunoglobulin G (IgG) involvement in HAR. METHODS: We recovered en bloc multivisceral grafts (distal esophagus, stomach, small intestine, colon, liver, pancreas, and kidneys) from rabbits (n = 20) and implanted them in the swine (n = 15) or rabbits (n = 5, control)...
September 2012: Xenotransplantation
https://www.readbyqxmd.com/read/22719772/myositic-type-of-idiopathic-orbital-pseudotumor-in-a-4-year-old-child-a-case-report
#14
Selim Bakan, Ayse Ahsen Bakan, Abdullah Kursat Cingu, Mehtap Beker Acay, Ahmet Gocmez, Ahmet Elbeyli, Serra Sencer
Idiopathic orbital pseudotumor is a benign, noninfectious, and nonneoplastic disease with unknown cause. It is the third most common orbital disease after thyroid orbitopathy and lymphoproliferative disorder. Idiopathic orbital pseudotumor is extremely rare in pediatric age group and may cause real diagnostic problems. This paper describes a 4-year-old girl who presented with sudden ptosis in the right eye and swollen eyelid. She recovered completely with high-dose steroid therapy. We report clinical and magnetic resonance imaging findings of orbital myositis, which is a rare subtype of idiopathic orbital pseudotumor in children and needs to be differentiated from other orbital disease especially malignancy...
2012: Case Reports in Medicine
https://www.readbyqxmd.com/read/22495866/neuritis-ossificans-of-the-radial-nerve
#15
Nasir Muzaffar, Nawaz Ahmad, Aejaz Bhat, Nissar Shah
Neuritis ossificans is a rare reactive process affecting the peripheral nerves that is challenging to diagnose and treat. The usual presentation is mononeuropathy, pain, variable weakness, and a palpable mass along the nerve distribution. A paucity of literature exists on this disorder. It is often confused with myositis ossificans; many cases in the literature have reported myositic masses that have caused neuropathies. Diagnosing neuritis ossificans requires a high degree of clinical suspicion and excellent radiological and histopathological evaluation...
April 2012: Orthopedics
https://www.readbyqxmd.com/read/20625308/cardiological-features-in-idiopathic-inflammatory-myopathies
#16
REVIEW
Chiara Bazzani, Ilaria Cavazzana, Angela Ceribelli, Enrico Vizzardi, Livio Dei Cas, Franco Franceschini
Idiopathic inflammatory myopathies (IIMs) represent a heterogeneous group of autoimmune systemic diseases characterized by chronic muscle weakness and inflammatory cell infiltrates in skeletal muscle. The most frequent IIMs, such as adult-onset polymyositis and dermatomyositis, display a wide range of clinical manifestations other than myositis, including skin changes, Raynaud's phenomenon and interstitial lung disease. Cardiac involvement is now well recognized as a clinically important manifestation in patients with polymyositis or dermatomyositis, although its actual frequency is still uncertain...
December 2010: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/19683369/-polymyositis-and-dermatomyositis-in-adults-tunisian-multicentre-study
#17
MULTICENTER STUDY
S Toumi, H Ghnaya, A Braham, I Harrabi, C Laouani-Kechrid
INTRODUCTION: To study the clinical features and the outcome of polymyositis (PM) and dermatomyositis (DM) in Tunisia. METHODS: Retrospective multicentre study conducted by the Tunisian Society of Internal Medicine. Adult patients with confirmed and probable PM and DM, according to the Bohan and Peter's criteria, were included in the study and followed-up between 1987 and 2005. RESULTS: Twenty cases of PM and 50 cases of DM were included. Female/male sex-ratio was 2...
September 2009: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/19086077/immune-mediated-myositis-in-crohn-s-disease
#18
Takashi Shimoyama, Yohei Tamura, Tsuyoshi Sakamoto, Kiyoharu Inoue
We report a patient with uncontrolled Crohn's disease who presented with progressive weakness of proximal muscles and a marked elevation of serum creatine kinase. Muscle biopsy from the left deltoid exhibited myositic changes with inflammatory infiltrates in the perimysium, endomysium, and perivascular locations. Most were stained as CD68-positive macrophages, whereas some were CD4- and CD8-positive T lymphocytes. Due to uncontrolled bowel inflammation, several fistulae were found in the descending colon, and partial colectomy was performed...
January 2009: Muscle & Nerve
https://www.readbyqxmd.com/read/19002546/association-of-idiopathic-inflammatory-myopathy-and-crohn-s-disease
#19
N Szabo, Sz Lukacs, I Kulcsar, W Gunasekera, A Nagy-Toldi, B Dezso, K Danko
We describe a rare case of concurrent polymyositis and Crohn's disease in a female patient. A 69-year-old female presented in December 2007 with a 5-month history of proximal muscle weakness, pain, fatigue and difficulty in walking and swallowing. Blood tests revealed elevated creatine kinase (3,429 U/l) and lactate dehydrogenase (2,013 U/l) levels. Magnetic resonance imaging found lumbar disc protrusion. Review by immunologists showed a diagnosis of idiopathic inflammatory myopathy. Though electromyography and muscle biopsy at this point were non-specific, corticosteroid treatment was commenced...
January 2009: Clinical Rheumatology
https://www.readbyqxmd.com/read/18848535/interpretation-of-creatine-kinase-and-aldolase-for-statin-induced-myopathy-reliance-on-serial-testing-based-on-biological-variation
#20
Alan H B Wu, Andrew Smith, Frank Wians
BACKGROUND: Statins are widely used drugs to reduce LDL cholesterol and risk for cardiovascular disease. Varying degrees of myopathies occur with statin use, ranging from mild myalgic symptoms alone to documented muscle damage and rhabdomyolysis. The activity of creatine kinase (CK) above a population-based reference range has been used to differentiate myalgias from documented myositic injury due to statins. However, because normal ranges for CK depend on gender, exercise, and ethnicity and are necessarily broad, it is possible for a patient to have myositic injury with a result that is within the reference range...
January 2009: Clinica Chimica Acta; International Journal of Clinical Chemistry
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