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Hemostatic agent

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https://www.readbyqxmd.com/read/28541681/platelet-microcapsule-hybrids-leverage-contractile-force-for-targeted-delivery-of-hemostatic-agents
#1
Caroline E Hansen, David R Myers, Wallace Hunter Baldwin, Yumiko Sakurai, Shannon L Meeks, L Andrew Lyon, Wilbur A Lam
We report a cell-mediated, targeted drug delivery system utilizing polyelectrolyte multilayer capsules that hybridize with the patient's own platelets upon intravenous administration. The hybridized platelets function as the sensor and actuator for targeted drug delivery and controlled release in our system. These capsules are biochemically and mechanically tuned to enable platelet adhesion and capsule rupture upon platelet activation and contraction, enabling the targeted and controlled "burst" release of an encapsulated biotherapeutic...
May 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28532074/highly-effective-cu-zn-carbon-micro-nanofiber-polymer-nanocomposite-based-wound-dressing-biomaterial-against-the-p-aeruginosa-multi-and-extensively-drug-resistant-strains
#2
Mohammad Ashfaq, Nishith Verma, Suphiya Khan
Pseudomonas aeruginosa (P. aeruginosa) is the most prevalent bacteria in the infections caused by burn, surgery, and traumatic injuries. Emergence of the P. aeruginosa bacterial resistance against various clinical drugs for wound treatment is the major concern nowadays. The present study describes the synthesis of the polyvinyl alcohol (PVA) and cellulose acetate phthalate (CAP) polymeric composite film (~0.2mm thickness) reinforced with the Cu/Zn bimetal-dispersed activated carbon micro/nanofiber (ACF/CNF), as a wound dressing material...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28512545/effect-of-hemostatic-agent-on-marginal-gaps-of-class-v-giomer-restorations
#3
Soodabeh Kimyai, Fatemeh Pournaghi-Azar, Narmin Mohammadi, Mahdieh Babri
BACKGROUND: Contamination of dentin with hemostatic agents might exert a deleterious effect on adhesive procedures on dentin. The present study was undertaken to investigate the effect of aluminum chloride hemostatic agent on marginal gaps in Cl V giomer restorations. MATERIAL AND METHODS: Fifty sound bovine permanent incisors were selected for the purpose of this in vitro study and Cl V cavities were prepared on their buccal surfaces; the gingival margins of the cavities were placed in dentin...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28509508/a-survey-on-prevalence-causes-and-prevention-of-postcementation-hypersensitivity
#4
Zülfikar Demirtag, Recep Uzgur, Mustafa Turkal, Zeynep Uzgur, Hakan Çolak, Mutlu Özcan
This study evaluated the prevalence and causes of post-cementation sensitivity and possible prevention measures according to the experience of dentists through an internet survey. A questionnaire was prepared with 25 items based on a survey introduced by Rosenstiel and Rashid. An online site was created for the participation to the survey. A total of 322 participants responded the questionnaire. The results of the questionnaire indicated the amount of tooth preparation (42.1%) is the most frequent reason for hypersensitivity followed by water-cooling with pressure (11...
September 2016: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28507786/application-of-hyperosmotic-nanoemulsions-in-wound-healing-partial-thickness-injury-model-in-swine
#5
Sean Connell, Jianming Li, Abigail Durkes, Lynetta Freeman
Objective: In this work, we introduce a novel hyperosmotic nanoemulsion (HNE) topical agent for use in wound healing. These topical emulsion complexes combine a lipophilic thymol nanoemulsion with a hyperosmotic saccharide matrix. This combination has been previously shown to possess synergistic antimicrobial activity against a host of common and drug-resistant pathogens in vitro. Approach: In this study, we present additional data to assess the safety and efficacy of these emulsions in a partial thickness injury model in swine...
May 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28485544/tc-325-versus-the-combined-conventional-technique-for-endoscopic-treatment-of-peptic-ulcers-with-high-risk-bleeding-stigmata-a-pilot-randomised-study
#6
Boon Eu Andrew Kwek, Tiing Leong Ang, Peng Lan Jeannie Ong, Yi Lyn Jessica Tan, Shih Wen Daphne Ang, Ngai Moh Law, Prem Harichander Thurairajah, Kwong Ming Fock
BACKGROUND: Preliminary studies on a new topical hemostatic agent TC-325 show its safety and effectiveness in the treatment of active upper GI bleeding. However, to date, there are no randomized trials comparing Hemospray with the combined conventional technique (CCT). Our pilot study aimed to compare the efficacy and safety of Hemospray with that of the CCT in treating peptic ulcers with active bleeding or high-risk stigmata. METHOD: This was a randomized comparative study of patients with upper GI bleeding symptoms and had Forrest class I, IIA or IIB ulcers...
May 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28483021/an-outbreak-of-surgical-site-infections-in-a-neurosurgical-ward
#7
Xia Mu, Huai Yang, Jianyi Wang
Objective To survey an outbreak of surgical site infections in a neurosurgery ward of a tertiary hospital. Methods The patients of surgical site infection were investigated individually based on a uniformly designed epidemiological survey form. The distribution of cases was analyzed by characteristic epidemiology,and a case-control study was carried to explore the risk factors. Results A total of 9 patients with surgical site infections from February 5 to March 7,2014 were identified in 68 patients who had received surgery in a neurosurgery ward,yielding a prevalence of 13...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28482536/influences-of-mesoporous-zinc-calcium-silicate-on-water-absorption-degradability-antibacterial-efficacy-hemostatic-performances-and-cell-viability-to-microporous-starch-based-hemostat
#8
Yu Hou, Yan Xia, Yongkang Pan, Songchao Tang, Xiaofei Sun, Yang Xie, Han Guo, Jie Wei
Efficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content. Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28471371/the-reversal-of-direct-oral-anticoagulants-in-animal-models
#9
Markus Honickel, Necib Akman, Oliver Grottke
Several direct oral anticoagulants (DOACs), including direct thrombin and factor Xa inhibitors, have been approved as alternatives to vitamin K antagonist (VKA) anticoagulants. As with any anticoagulant, DOAC use carries a risk of bleeding. In patients with major bleeding or needing urgent surgery, reversal of DOAC anticoagulation may be required, presenting a clinical challenge. The optimal strategy for DOAC reversal is being refined, and may include use of hemostatic agents such as prothrombin complex concentrates (PCCs; a source of concentrated clotting factors), or DOAC-specific antidotes (which bind their target DOAC to abrogate its activity)...
April 4, 2017: Shock
https://www.readbyqxmd.com/read/28470674/acquired-hemophilia-a-updated-review-of-evidence-and-treatment-guidance
#10
REVIEW
Rebecca Kruse-Jarres, Christine L Kempton, Francesco Baudo, Peter W Collins, Paul Knoebl, Cindy A Leissinger, Andreas Tiede, Craig M Kessler
Acquired hemophilia A (AHA) is a rare disease resulting from autoantibodies (inhibitors) against endogenous factor VIII (FVIII) that leads to bleeding, which is often spontaneous and severe. AHA tends to occur in elderly patients with comorbidities and is associated with high mortality risk from underlying comorbidities, bleeding, or treatment complications. Treatment, which consists of hemostatic management and eradication of the inhibitors, can be challenging to manage. Few data are available to guide the management of AHA-related bleeding and eradication of the disease-causing antibodies...
May 3, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28450136/the-use-of-topical-hemostatic-agents-in-cardiothoracic-surgery
#11
REVIEW
Art Bracey, Aryeh Shander, Solomon Aronson, Bradley A Boucher, Domenico Calcaterra, Michael W A Chu, Richard Culbertson, Karim Jabr, Henrik Kehlet, Omar Lattouf, S Chris Malaisrie, C David Mazer, Martin M Oberhoffer, Sherri Ozawa, Theolyn Price, Todd Rosengart, Bruce D Spiess, Giuseppe Turchetti
Topical hemostatic agents are used in conjunction with conventional procedures to reduce blood loss. They are often used in cardiothoracic surgery, which is particularly prone to bleeding risks. Variation in their use exists because detailed policy and practice guidelines reflecting the current medical evidence have not been developed to promote best surgical practice in this setting. To address this need, the Society for the Advancement of Blood Management convened an International Hemostatic Expert Panel...
April 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28449940/antimicrobial-activity-of-chemomechanical-gingival-retraction-products
#12
Belinda Hsu, Stephanie Lee, Donald Schwass, Geoffrey Tompkins
BACKGROUND: Application of astringent hemostatic agents is the most widely used technique for gingival retraction, and a variety of products are offered commercially. However, these products may have additional unintended yet clinically beneficial properties. The authors assessed the antimicrobial activities of marketed retraction products against plaque-associated bacteria in both planktonic and biofilm assays, in vitro. METHODS: The authors assessed hemostatic solutions, gels, pellets, retraction cords, pastes, and their listed active agents against a collection of microorganisms by means of conventional agar diffusion and minimum bacteriostatic and bactericidal concentration determinations...
April 24, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28439721/incidence-of-thromboembolic-events-after-use-of-gelatin-thrombin-based-hemostatic-matrix-during-intracranial-tumor-surgery
#13
Roberto Gazzeri, Marcelo Galarza, Carlo Conti, Costanzo De Bonis
Association between the use of hemostatic agents made from collagen/gelatin mixed with thrombin and thromboembolic events in patients undergoing tumor resection has been suggested. This study evaluates the relationship between flowable hemostatic matrix and deep vein thrombosis in a large cohort of patients treated for brain tumor removal. The authors conducted a retrospective, multicenter, clinical review of all craniotomies for tumor removal performed between 2013 and 2014. Patients were classified in three groups: group I (flowable gelatin hemostatic matrix with thrombin), group II (gelatin hemostatic without thrombin), and group III (classical hemostatic)...
April 24, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28403392/association-of-central-nervous-system-depression-with-topical-brimonidine-when-used-for-hemostasis-a-serious-adverse-event
#14
Devorah R Shagalov, Drew Taylor, Rachel Schleichert, Jonathan Weiss, Eduardo Weiss
Importance: Minor bleeding is the most common complication of dermatologic surgery. Topical brimonidine, 0.33%, gel has been reported for the use of hemostasis in dermatologic surgery. The safety profile and risk of systemic toxic effects when brimonidine is used topically for hemostasis is unknown. Objective: To determine the risk of systemic toxic effects of topical brimonidine, 0.33%, gel when used for hemostasis. Design, Setting, and Participants: In this case series from a private practice (Hollywood Dermatology), 2 patients presented for dermatologic procedures, complicated by persistent bleeding...
April 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28396682/heterologous-fibrin-sealant-derived-from-snake-venom-from-bench-to-bedside-an-overview
#15
REVIEW
Rui Seabra Ferreira, Luciana Curtolo de Barros, Luciana Patrícia Fernandes Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Leticia Gomes de Pontes, Lucilene Delazari Dos Santos, Benedito Barraviera
Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28395294/treatment-of-persistent-gross-hematuria-with-tranexamic-acid-in-autosomal-dominant-polycystic-kidney-disease
#16
Qing Yao, Ming Wu, Jie Zhou, Meiyang Zhou, Dongping Chen, Lili Fu, Rongrong Bian, Xiaohong Xing, Lijun Sun, Xiaohong Hu, Lin Li, Bing Dai, Rudolf P Wüthrich, Yiyi Ma, Chang-Lin Mei
BACKGROUND/AIMS: In this retrospective study we aimed to compare the effect of tranexamic acid (TXA) vs etamsylate, two hemostatic agents, on hematuria duration in autosomal dominant polycystic kidney disease (ADPKD) patients with persistent gross hematuria. METHODS: This is a retrospective study of 40 patients with ADPKD and macroscopic hematuria. 20 patients receiving TXA and snake venom blood clotting enzyme injection were compared with 20 matched patients receiving etamsylate and snake venom blood clotting enzyme injection...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28393462/current-use-of-factor-concentrates-in-pediatric-cardiac-anesthesia
#17
REVIEW
Nina A Guzzetta, Glyn D Williams
Excessive bleeding following pediatric cardiopulmonary bypass is associated with increased morbidity and mortality, both from the effects of hemorrhage and the therapies employed to achieve hemostasis. Neonates and infants are especially at risk because their coagulation systems are immature, surgeries are often complex, and cardiopulmonary bypass technologies are inappropriately matched to patient size and physiology. Consequently, these young children receive substantial amounts of adult-derived blood products to restore adequate hemostasis...
April 10, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28387542/the-risk-of-bleeding-with-the-use-of-antiplatelet-agents-for-the-treatment-of-cardiovascular-disease
#18
Ashwin S Nathan, Sounok Sen, Robert W Yeh
In the presence of injured coronary vascular endothelium, platelets become activated to form hemostatic plugs. While this represents a normal healing response to disrupted vascular endothelium, occlusive cardiovascular disease, as a result of maladaptive thrombus formation, is a major cause of morbidity and mortality. Due to the platelet predominance of arterial thrombi, antiplatelet agents are the mainstay of therapy for arterial cardiovascular disease, though come with a significantly increased risk of bleeding...
May 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28386291/bletilla-striata-micron-particles-function-as-a-hemostatic-agent-by-promoting-rapid-blood-aggregation
#19
Chen Zhang, Rui Zeng, Zhencheng Liao, Chaomei Fu, Hui Luo, Hanshuo Yang, Yan Qu
The human body cannot control blood loss without treatment. Available hemostatic agents are ineffective at treating cases of severe bleeding and are expensive or raise safety concerns. Bletilla striata serve as an inexpensive, natural, and promising alternative. However, no detailed studies on its hemostatic approach have been performed. The aim of this study was to examine the hemostatic effects of B. striata Micron Particles (BSMPs) and their hemostatic mechanisms. We prepared and characterized BSMPs of different size ranges and investigated their use as hemostatic agent...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28384465/multicenter-retrospective-study-of-the-risk-factors-of-hemorrhage-after-tooth-extraction-in-patients-receiving-antiplatelet-therapy
#20
Souichi Yanamoto, Takumi Hasegawa, Satoshi Rokutanda, Sayaka Komori, Akira Tachibana, Yuka Kojima, Yoshito Koyama, Yasuyuki Shibuya, Hiroshi Kurita, Takahide Komori, Masahiro Umeda
PURPOSE: To identify the risk factors affecting hemorrhage after tooth extraction in patients receiving antiplatelet therapy, this study investigated the relation between various factors and hemorrhage events after tooth extraction. PATIENTS AND METHODS: The records of 264 patients receiving antiplatelet therapy who underwent tooth extraction were retrospectively reviewed from 6 institutions belonging to the Japanese Study Group of Cooperative Dentistry with Medicine...
March 14, 2017: Journal of Oral and Maxillofacial Surgery
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