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Cost effectiveness clozapine

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https://www.readbyqxmd.com/read/27648956/withdrawn-risperidone-versus-other-atypical-antipsychotic-medication-for-schizophrenia
#1
Simon Gilbody, Anne-Marie Bagnall, Lorna Duggan, Arja Tuunainen
BACKGROUND: Risperidone is one of a number of 'atypical antipsychotics' which are currently being marketed for the treatment of those with schizophrenia, largely on the basis of claims of improved tolerability and effectiveness compared to much cheaper conventional antipsychotics. The efficacy of risperidone has already been compared to conventional drugs, but it remains unclear how risperidone compares with other atypical antipsychotic drugs such as clozapine. OBJECTIVES: To determine the effects of risperidone compared with other atypical antipsychotic drugs for schizophrenia...
September 20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27629356/current-understanding-of-psychosis-in-parkinson-s-disease
#2
REVIEW
Oluwadamilola O Ojo, Hubert H Fernandez
Psychosis in Parkinson's disease (PD) is one of the greatest determinants of nursing home placement and caregiver stress. Traditionally associated with medications with dopaminergic effect, it has now been linked to other medications and other stressors e.g. systemic illnesses. The development of hallucinations in a PD patient can herald the onset of dementia and usually predicts increased mortality risk. Medication reduction in PD psychosis usually reduces the symptoms; however, this comes at the cost of worsening motor function...
October 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27496180/design-and-protocol-for-the-focusing-on-clozapine-unresponsive-symptoms-focus-trial-a-randomised-controlled-trial
#3
Melissa Pyle, John Norrie, Matthias Schwannauer, David Kingdon, Andrew Gumley, Douglas Turkington, Rory Byrne, Suzy Syrett, Graeme MacLennan, Robert Dudley, Hamish J McLeod, Helen Griffiths, Samantha Bowe, Thomas R E Barnes, Paul French, Paul Hutton, Linda Davies, Anthony P Morrison
BACKGROUND: For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozapine is the only antipsychotic with convincing efficacy for people whose symptoms are considered treatment-resistant to antipsychotic medication. However, 30-40 % of such conditions will have an insufficient response to the drug. Cognitive behavioural therapy has been shown to be an effective treatment for schizophrenia when delivered in combination with antipsychotic medication, with several meta-analyses showing robust support for this approach...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27403276/risks-and-benefits-of-rapid-clozapine-titration
#4
Jeannie D Lochhead, Michele A Nelson, Alan L Schneider
Clozapine is often considered the gold standard for the treatment of schizophrenia. Clinical guidelines suggest a gradual titration over 2 weeks to reduce the risks of adverse events such as seizures, hypotension, agranulocytosis, and myocarditis. The slow titration often delays time to therapeutic response. This raises the question of whether, in some patients, it may be safe to use a more rapid clozapine titration. The following case illustrates the potential risks associated with the use of multiple antipsychotics and rapid clozapine titration...
May 18, 2016: Mental Illness
https://www.readbyqxmd.com/read/27301766/the-business-case-for-expanded-clozapine-utilization
#5
Jessica L Gören, Adam J Rose, Eric G Smith, John P Ney
OBJECTIVE: In most settings, less than 25% of patients with treatment-resistant schizophrenia receive clozapine, the only medication proven effective for treatment-resistant schizophrenia. Therefore, a business case analysis was conducted to assess whether increasing clozapine utilization for treatment-resistant schizophrenia in a health care system would result in direct health care cost savings. METHODS: Veterans with treatment-resistant schizophrenia who were treated in the Veterans Health Administration (VHA) were studied...
June 15, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27251620/decreasing-striatopallidal-pathway-function-enhances-motivation-by-energizing-the-initiation-of-goal-directed-action
#6
Fernanda Carvalho Poyraz, Eva Holzner, Matthew R Bailey, Jozsef Meszaros, Lindsay Kenney, Mazen A Kheirbek, Peter D Balsam, Christoph Kellendonk
UNLABELLED: Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated D2Rs (D2R-OEdev mice) are reversed by decreasing function of the striatopallidal "no-go" pathway. To this end, we expressed the Gαi-coupled designer receptor hM4D in adult striatopallidal neurons and activated the receptor with clozapine-N-oxide (CNO)...
June 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27132755/-cost-effectiveness-of-antipsychotics-in-the-maintenance-treatment-of-schizophrenia-in-colombia
#7
Hoover Quitian Reyes, Jair Alberto Arciniegas Barrera, Adriana Bohórquez Peñaranda, Carlos Gómez Restrepo
OBJECTIVE: Assess the cost-effectiveness of the antipsychotics for treatment of schizophrenia. METHODS: A five-year Markov model was built form patients with schizophrenia on the stage of maintenance. Costs were taken from the perspective of the Colombian health care system (Sistema General de Seguridad Social en Salud). The effectiveness was measured in years of life under the same maintenance plan. RESULTS: The Markov model indicated clozapine as the as the most cost-effective alternative between the first line antipsychotics and haloperidol is it when comparing other antipsychotics...
April 2016: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/26784704/strong-treatment-response-and-high-maintenance-rates-of-clozapine-in-childhood-onset-schizophrenia
#8
Lauren I Kasoff, Kwangmi Ahn, Peter Gochman, Diane D Broadnax, Judith L Rapoport
OBJECTIVE: Childhood-onset schizophrenia (COS) is a rare but severe form of the disorder, which is often treatment refractory. Short-term studies have indicated a greater differential efficacy, evident through effect sizes, favoring clozapine over other agents in alleviating negative symptoms in COS patients compared with adult-onset patients (AOS). There have been no data for COS patients on long-term compliance with clozapine treatment. Therefore, we wanted to know, over a span of up to 24 years, how many of our COS cohort had remained on clozapine for at least 2 years...
June 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26406773/estimating-the-impact-of-adherence-to-and-persistence-with-atypical-antipsychotic-therapy-on-health-care-costs-and-risk-of-hospitalization
#9
Yawen Jiang, Weiyi Ni
STUDY OBJECTIVE: To estimate the impact of adherence to and persistence with atypical antipsychotics on health care costs and risk of hospitalization by controlling potential sources of endogeneity. DESIGN: Retrospective cohort study using medical and pharmacy claims data. DATA SOURCE: Humana health care insurance database. PATIENTS: A total of 32,374 patients with a diagnosis of schizophrenia or bipolar disorder and who had a prescription for noninjectable atypical antipsychotics (aripiprazole, asenapine, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, or ziprasidone), after a washout period of at least 180 days during which there was no use of any atypical antipsychotics, between January 2007 and June 2013...
September 2015: Pharmacotherapy
https://www.readbyqxmd.com/read/26384040/simple-and-accurate-quantitative-analysis-of-16-antipsychotics-and-antidepressants-in-human-plasma-by-ultrafast-high-performance-liquid-chromatography-tandem-mass-spectrometry
#10
Jingjing Wang, Hua Huang, Qin Yao, Yang Lu, Qiaoling Zheng, Yuqi Cheng, Xiufeng Xu, Qiong Zhou, Di Wu, Min Zhang, Xiaosu Li, Jun Zhang
BACKGROUND: In psychopharmacology, treatment with psychotropic drugs is often suboptimal, mainly because of the high interindividual variability in pharmacokinetic properties. Therapeutic drug monitoring (TDM) can be a valuable tool for monitoring the individual effects of a prescribed dosage in a patient, and it facilitates antipsychotic treatment by increasing the effectiveness and safety of drugs and by reducing treatment costs. The aim of this study was to develop and validate an ultrafast liquid chromatography (UFLC) method with tandem mass spectrometric detection for the measurement of 16 antipsychotics and antidepressants in human plasma samples for TDM or other applications...
October 2015: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/26349082/automated-analysis-of-clozapine-and-norclozapine-in-human-plasma-using-novel-extraction-plate-technology-and-flow-injection-tandem-mass-spectrometry
#11
COMPARATIVE STUDY
Lewis Couchman, Krithika Subramaniam, Danielle S Fisher, Sarah L Belsey, Simon A Handley, Robert J Flanagan
BACKGROUND: Analysis of plasma clozapine and N-desmethylclozapine (norclozapine) for therapeutic drug monitoring purposes is well established. To minimize analysis times and facilitate rapid reporting of results, we have fully automated sample preparation using novel AC Extraction Plates and a Tecan Freedom EVO 100 liquid handling platform, and minimized extract analysis times using flow-injection tandem mass spectrometry (FIA-MS/MS). METHODS: Analytes and deuterium-labeled internal standards were extracted from plasma (100 μL) at pH 10...
February 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/26166233/treatment-of-tardive-dystonia-induced-by-antipsychotics-old-and-new
#12
Philippos Gourzis, Maria Skokou, Evanthia Soubasi, Aggeliki Katrivanou, Panagiotis Polychronopoulos
OBJECTIVES: Tardive dystonia is a serious extrapyramidal side effect emerging after long-term treatment with antipsychotics, frequently with a deteriorating course, and unsatisfactory treatment. Presently, clozapine is used for the cotreatment of tardive dystonia and psychosis, at the cost of serious side effects. Apart from clozapine, there have been case reports describing positive effects of quetiapine on dystonic symptoms. Aim of the present study was to demonstrate the ameliorating effects of quetiapine on dystonic symptoms, in a sample of patients suffering from antipsychotic-induced tardive dystonia...
July 2015: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/26085043/pharmacological-management-of-lewy-body-dementia-a-systematic-review-and-meta-analysis
#13
REVIEW
Chris Stinton, Ian McKeith, John-Paul Taylor, Louise Lafortune, Eneida Mioshi, Elijah Mak, Victoria Cambridge, James Mason, Alan Thomas, John T O'Brien
OBJECTIVE: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia. METHOD: Studies were identified through bibliographic databases, trials registers, gray literature, reference lists, and experts. The authors used the search terms "Lewy or parkinson" and "dementia" through March 2015 and used the following inclusion criteria: participants with diagnoses of Lewy body dementia, dementia with Lewy bodies, or Parkinson's disease dementia (or participants' caregivers); investigation of pharmacological management strategies; outcome measures and test scores reported...
August 1, 2015: American Journal of Psychiatry
https://www.readbyqxmd.com/read/25376164/comparison-of-sole-nurse-and-team-delivered-community-clozapine-services-for-people-with-treatment-resistant-schizophrenia
#14
COMPARATIVE STUDY
Heather Gage, Hannah Family, Fenella Murphy, Peter Williams, Jane Sutton, Denise Taylor
AIM: To compare sole nurse and doctor-led multidisciplinary team delivery of community clozapine services for people with treatment-resistant schizophrenia. BACKGROUND: Around 20% of people with schizophrenia are treatment resistant and fail to respond to front line medications. Clozapine, a second-line treatment, has potentially serious side effects requiring regular monitoring. Different models of community clozapine services are emerging in the British National Health Service, but there is little evidence about which is best...
March 2015: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/25201058/the-practical-management-of-refractory-schizophrenia-the-maudsley-treatment-review-and-assessment-team-service-approach
#15
K Beck, R McCutcheon, M A P Bloomfield, F Gaughran, T Reis Marques, J MacCabe, S Selvaraj, D Taylor, O D Howes
OBJECTIVE: To describe a practical approach to the community management of treatment-resistant schizophrenia (TRS). METHOD: A descriptive review of an approach to the assessment and management of patients with TRS, including the community titration of clozapine treatment, and a report of the management recommendations for the first one hundred patients assessed by the Treatment REview and Assessment Team (TREAT). RESULTS: The standardized model for the community assessment, management and titration of clozapine is described...
December 2014: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/25185985/pharmacogenomics-in-psychiatry-implications-for-practice
#16
REVIEW
Thea R Moore, Angela M Hill, Siva K Panguluri
Psychotropic medications are used for numerous psychiatric and neurologic disorders, and are associated with in some cases life-threatening adverse effects, high acquisition costs, stringent monitoring requirements, and potential interactions with other medications. Because of the risks of adverse effects and need for adherence, risk mitigation strategies are being implemented to protect consumers. An understanding of receptor activities, cytochrome P450 2D6 and 2C19 metabolism, overlapping pharmacology, and polymorphic biomarkers for the dopamine 2 D2 receptor gene (DRD2) and dopamine 3 D3 receptor gene (DRD3), serotonin 2A and 2C receptor genes (5HTR2A and 5HTR2C), and human leukocyte antigen (HLA) variants creates opportunities for the integration of pharmacogenomics, and can assist in the application of personalized medicine in this arena...
2014: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/24968989/cost-effectiveness-of-second-generation-antipsychotics-for-the-treatment-of-schizophrenia
#17
COMPARATIVE STUDY
Taehwan Park, Karen M Kuntz
OBJECTIVE: To compare the cost-effectiveness of alternate treatment strategies using second-generation antipsychotics (SGAs) for patients with schizophrenia. METHODS: We developed a Markov model to estimate the costs and quality-adjusted life-years (QALYs) for different sequences of treatments for 40-year-old patients with schizophrenia. We considered first-line treatment with one of the four SGAs: olanzapine (OLZ), risperidone (RSP), quetiapine (QTP), and ziprasidone (ZSD)...
June 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/24921226/the-pharmaco-economics-of-atypical-antipsychotics
#18
D Taylor, K Aitchison
Atypical antipsychotics are claimed to show advantages in efficacy and tolerability when compared with older, typical drugs. However, the purchase cost of atypicals far exceeds that of typical drugs. Pharmaco-economic evaluations of the use of atypical agents are used, in essence, to determine whether or not the benefit gained by using atypicals is greater than the extra cost of their acquisition. Several forms of pharmaco-economic evaluation have been developed, but none provides definitive, unarguable findings...
1999: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/24863739/changes-in-the-prescription-pattern-of-antipsychotics-for-schizophrenic-outpatients-after-the-implementation-of-a-global-budgeting-program
#19
Hsien-Jane Chiu, Po-Han Chou, El-Wui Loh, Tzuo-Yun Lan, Bo-Jian Wu, Yung-Yan Chang, Shuen-Zen Liu, Tsuo-Hung Lan
BACKGROUND: A hospital-based global budget (GB) program was implemented by the Taiwan Bureau of National Health Insurance (TBNHI) to control the rising costs of medical care. We investigated whether the introduction of the GB program affected prescriptions for second-generation antipsychotics (SGAs) for schizophrenic outpatients in public and private medical and psychiatric centers. METHODS: The prescription data of schizophrenic outpatients treated between 2001 and 2004 were retrieved from the TBNHI database, which included outpatients who were diagnosed as having schizophrenia during the period from 1996 to 2001...
June 2014: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/24696414/monitoring-and-management-of-metabolic-abnormalities-mixed-method-evaluation-of-a-successful-intervention
#20
Eleanor Wilson, Christopher Randall, Sue Patterson, Brett Emmerson, Vikas Moudgil, Tim Weaver
OBJECTIVE: To describe the process and impact of a service-level intervention on metabolic monitoring and follow-up of patients of a mental health service who were prescribed clozapine, and describe the metabolic health of these patients. METHODS: The intervention - Let's Get Physical - involved designating two months annually as 'physical health months', during which revised service protocol required metabolic monitoring for all eligible patients. Mixed methods were used to assess rates of monitoring at baseline, during the two physical health months, and follow-up and factors influencing practice...
June 2014: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
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