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L Klotz, A Loblaw, R Siemens, P Ouellette, A Kapoor, M Kebabdjian, L Zhang, F Saad
BACKGROUND: In men initiating intermittent androgen deprivation therapy (IADT), a range of induction durations, between 3 and 12 months, have been employed. OBJECTIVE: To determine if the duration of induction ADT influences the duration of the off treatment interval and the recovery of serum testosterone (T). MANEUVER: This was a prospective, randomized, open label study. Men with biochemical recurrence after local therapy for prostate cancer, with a negative bone scan, were randomized between 4 and 10 months of monthly Degarelix...
March 10, 2018: Journal of Urology
Juan Hu, Jinggui Wu, Xiaojing Qu, Jianming Li
The objective of this work was to evaluate the variation in the amount and structure of humic acid (HA) after the application of organic wastes (OWs) in semiarid soil under plastic mulched drip irrigation, measured by elemental composition, excitation-emission matrix (EEM) fluorescence, and carbon 13 nuclear magnetic resonance (13 C CPMAS NMR). The experiment involved chemical fertilizer combined with chicken manure (CM), sheep manure (SM), maize straw (MS), fodder grass (FG), and tree leaves (TL), while chemical fertilizer only was used as control (CK)...
February 22, 2018: Chemosphere
Ali Eren, Hakan Atalar, Cemile Merve Seymen, Ferda Alpaslan Pınarlı, Gulnur Take Kaplanoglu, Sacit Turanlı
PURPOSE: The aim of this study was to define a sutureless peripheral nerve repair technique with a vein graft and bone marrow-derived stem cells (BMSC) and compare it to epineural repair. MATERIALS AND METHODS: Thirty Wistar Albino rats were divided into five groups evenly. In the control group (C), epineural repair was performed. In the SV (suture + vein) and MSV (BMSC + suture + vein) groups, epineural repair was wrapped with a vein graft. In the V (vein) and MV (vein + BMSC) groups, sutureless repair using a vein graft was performed by taking sutures away from the regeneration site...
March 1, 2018: Microsurgery
Edyta Olakowska, Wiesław Marcol, Adam Właszczuk, Izabella Woszczycka-Korczyńska, Joanna Lewin-Kowalik
BACKGROUND: Spinal cord injury (SCI) is an important cause of impairment of sensory and motor nerve function. It has been shown that free-radical species play an important role in the pathogenesis of acute tissue trauma after SCI. There are no proven pharmacological therapies that provide neuroprotection and stimulate axonal growth after trauma. OBJECTIVES: The aim of this study was to investigate the neuroprotective effect of N-acetylcysteine (NAC) on the regeneration of spinal cord injuries in rats...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mingxing Zhang, Ye Zhang, Yuhong Bian, Hui Fu, Ying Xu, Yi Guo
BACKGROUND: Recently, application of electroacupuncture (EA) to stimulate nerve regeneration has become a mainstream treatment in clinical rehabilitation and related basic research, but the efficacy of long-term stimulation has not been confirmed. OBJECTIVE: To evaluate the influence of long term EA on peripheral nerve injury (PNI) from multiple angles. METHOD: Twenty-four rats were divided into three groups: control, PNI and PNI+EA. In the latter two groups, PNI was modelled by transection followed by re-anastomosis of thesciatic nerve...
February 7, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Muhammet Aydın, Elif Burcu Aydın, Mustafa Kemal Sezgintürk
Label-free immunosensor based on tetra armed star-shaped poly(glycidylmethacrylate) (Star PGMA ) modified disposable ITO electrode was developed for detection of p53 protein, an important colorectal cancer biomarker. This disposable biosensor was fabricated by spin-coating technique using star-shaped Star PGMA with epoxy side groups. After formation of a stable film with epoxy ends, anti-p53 antibodies were bound to these groups covalently. Stepwise modification of the electrode was followed by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) studies...
February 5, 2018: Biosensors & Bioelectronics
Richard A Furie, Daniel J Wallace, Cynthia Aranow, James Fettiplace, Barbara Wilson, Prafull Mistry, David A Roth, D Gordon
OBJECTIVE: This US multicenter continuation study (GSK Study BEL112233; NCT00724867) assessed long-term safety and efficacy of belimumab in patients with SLE who completed BLISS-76 (NCT00410384). METHODS: Patients continued to receive the same belimumab dose plus standard of care; patients previously receiving placebo received belimumab 10 mg/kg. Primary outcome measures included long-term safety (AE frequency and damage assessed by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI] evaluated every 48 weeks [study year])...
February 6, 2018: Arthritis & Rheumatology
Venkatesh Aithal, Joseph Kei, Carlie Driscoll, Michio Murakoshi, Hiroshi Wada
BACKGROUND: Diagnosing conductive conditions in newborns is challenging for both audiologists and otolaryngologists. Although high-frequency tympanometry (HFT), acoustic stapedial reflex tests, and wideband absorbance measures are useful diagnostic tools, there is performance measure variability in their detection of middle ear conditions. Additional diagnostic sensitivity and specificity measures gained through new technology such as sweep frequency impedance (SFI) measures may assist in the diagnosis of middle ear dysfunction in newborns...
February 2018: Journal of the American Academy of Audiology
Tasneem Mohammad, Aliaa Rehan Youssef
Background: Muscle strain is a common injury with a high recurrence rate. Due to the heterogeneity of strain injuries, experimental animals provide controlled and reproducible models to investigate such injuries. Sciatic Function Index (SFI) is a clinically feasible method to assess hind limb recovery in rodents after induced injuries. Objectives: To investigate time to recovery of SFI after induced-strain in tibialis anterior (TA) muscle in rats. Methods: Sixteen adult male Wister rats were randomly and equally divided to a normal control group that received no intervention, and TA induced muscle strain group...
July 2017: Muscles, Ligaments and Tendons Journal
Xiao-Bin Zhou, De-Xin Zou, Wei Gu, Dong Wang, Jian-Shu Feng, Jiang-Yong Wang, Jun-Lin Zhou
BACKGROUND: Researches have shown that ischemic preconditioning reduced the severity of ischemia-reperfusion injury in brain in rats, we have a hypothesis that repeated brief ischemia has positive effects on peripheral nerve damage. AIM: This study was conducted to investigate the potential protective effects of repeated brief ischemia on peripheral nerve regeneration using a rat model of experimental sciatic nerve transection injury. METHOD: Treatment groups (group A-D) received repeated brief ischemia every one day/two days/three days/7 days...
January 25, 2018: World Neurosurgery
Niranjan J Sathianathen, Stephanie Jarosek, Nathan Lawrentschuk, Damien Bolton, Badrinath R Konety
BACKGROUND: Traditional surgical risk indices are notoriously inaccurate, especially for the elderly, so there has been a trend to evaluate frailty instead. OBJECTIVE: To describe a simplified five-item frailty index for evaluating radical cystectomy outcomes and compare its predictive ability with other risk assessment tools for a total patient cohort and a subgroup of patients aged ≥65yr. DESIGN, SETTING, AND PARTICIPANTS: The National Surgical Quality Improvement Program (NSQIP) database from 2007 to 2015 was queried for radical cystectomy cases for bladder cancer...
January 20, 2018: European Urology Focus
Jong Soo Lee, Hye Sun Lee, Jee Soo Ha, Kyung Suk Han, Koon Ho Rha, Sung Joon Hong, Byung Ha Chung, Kyo Chul Koo
PURPOSE: The relationship between body fat distribution and survival remains unclear among patients with castration-resistant prostate cancer (CRPC) treated using docetaxel and androgen receptor-axis targeted agents. We investigated whether body composition parameters could predict radiographic progression-free survival (RFS) and cancer-specific survival (CSS) among patients with CRPC. MATERIALS AND METHODS: This multi-center retrospective study evaluated data from 282 consecutive patients who were diagnosed with CRPC between September 2009 and March 2017...
January 20, 2018: Journal of Urology
Nedal Massalha, Shengkun Dong, Michael J Plewa, Mikhail Borisover, Thanh H Nguyen
We investigated chronic mammalian cell cytotoxicity of wastewaters from four sources and their optical spectroscopic properties with or without chlorination or ozonation. Samples from effluents of activated sludge, nitrification tower, facultative waste stabilization pond, and maturation waste stabilization pond were either chlorinated or ozonated. The wastewater samples were analyzed for fluorescence excitation emission matrix, specific fluorescence index (SFI), and specific UV absorbance at 254 nm (SUVA)...
January 23, 2018: Environmental Science & Technology
Pi-Hui Hsu, Chao-Hsien Lee, Li-Kuo Kuo, Yu-Chung Kung, Wei-Ji Chen, Min-Su Tzeng
BACKGROUND: Due to studies on calorie requirement in mechanically ventilated critically ill elderly patients are few, and indirect calorimetry (IC) is not available in every intensive care unit (ICU). The aim of this study was to compare IC and Harris-Benedict (HB) predictive equation in different BMI groups. METHODS: A total of 177 mechanically ventilated critically ill elderly patients (≧65 years old) underwent IC for measured resting energy expenditure (MREE)...
January 11, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Caitlin Bertelsen, Hagit Shoffel-Havakuk, Karla O'Dell, Michael M Johns, Lindsay S Reder
Importance: Endoscopic dilation is the mainstay treatment strategy for subglottic and proximal tracheal stenosis (SGS/PTS). Its major limitation is restenosis requiring repeated surgery. Intralesional steroid injection (ISI) is a promising adjunctive treatment aimed at prolonging the effects of dilation. Objective: To evaluate the association of serial in-office ISI after endoscopic dilation with surgery-free interval (SFI) in adults with SGS/PTS. Design, Setting, and Participants: A retrospective study of adults with SGS/PTS who underwent at least 2 consecutive in-office ISI at the University of Southern California, Keck School of Medicine, over a 3-year period was conducted...
January 11, 2018: JAMA Otolaryngology—Head & Neck Surgery
Adnana Talic, Fuad Dzankovic, Adnan Papovic, Emina Omerhodzic
Introduction: Infections occurring in the wound as a consequence of the surgery represent the surgical field infections (SFI). Tibia diaphysis fractures are common due to its exposure to the external force. Clinical signs include: pain, swelling, lower leg deformity and skin changes. Tibia in the lower extremities has an eccentric position - from the front inner side it is covered only with the skin and from the back and the outer by muscle mass. The most common pathogens are: Staphylococcus aureus, Coagulase negative Staphylococcoc aureus or S...
October 2017: Medical Archives
Daniel F Martins, Thiago C Martins, Ana Paula Batisti, Larissa Dos Santos Leonel, Franciane Bobinski, Luiz A O Belmonte, Leidiane Mazzardo-Martins, Eduardo Cargnin-Ferreira, Adair R S Santos
Although training programs with regular eccentric (ECC) exercise are more commonly used for improving muscular strength and mobility, ECC exercise effects upon functional recovery of the sciatic nerve has not yet been determined. After sciatic nerve crush, different mice groups were subjected to run on the treadmill for 30 min at a speed of 6, 10, or 14 m/min with - 16° slope, 5 days per week, over 8 weeks. During the training time, neuropathic pain-like behavior (mechanical and cold hyperalgesia) was assessed and functional recovery was determined with the grip strength test and the Sciatic Functional and Static indexes (SFI and SSI)...
December 18, 2017: Molecular Neurobiology
Dae Hyun Kim, Sebastian Schneeweiss, Robert J Glynn, Lewis A Lipsitz, Kenneth Rockwood, Jerry Avorn
Background: Frailty is a key determinant of health status and outcomes of health care interventions in older adults that is not readily measured in Medicare data. This study aimed to develop and validate a claims-based frailty index (CFI). Methods: We used data from Medicare Current Beneficiary Survey 2006 (development sample: n = 5,593) and 2011 (validation sample: n = 4,424). A CFI was developed using the 2006 claims data to approximate a survey-based frailty index (SFI) calculated from the 2006 survey data as a reference standard...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ailing Cao, Hailang He, Mengxin Jing, Beibei Yu, Xianmei Zhou
Platinum-based chemotherapy is one of the standard treatments for non-small-cell lung cancer (NSCLC), while its high toxicity and limited clinical effects raise big concerns. Shenfu injection (SFI) has been commonly used as an adjutant chemotherapy drug for NSCLC in China. We ascertained the beneficial and adverse effects of SFI in combination with platinum-based chemotherapy for advanced NSCLC by using meta-analysis methods. The randomized controlled trials (RCTs) involving advanced NSCLC treatment with SFI plus platinum-based chemotherapy versus chemotherapy alone were searched on 6 medical databases up to February 2017...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Guoqing Tang, Jia Yao, Ruowu Shen, Aiyu Ji, Kai Ma, Beibei Cong, Fang Wang, Lingyu Zhu, Xuan Wang, Yingqiao Ding, Bei Zhang
Toll-like receptors (TLRs) are extremely significant pattern recognition receptors. When nerve injury occurs, a variety of inflammatory factors are generated, leading to an exceedingly complex micro-environment. TLRs recognize damage-associated molecular patterns. To investigate the correlation between TLR4 and recovery after sciatic nerve injury, the model of sciatic nerve injury was conducted using TLR4-mutated mice (C3H/HeJ) and wild mice (C3H/HeN). Our goal was to identify short-stage and long-stage changes after sciatic nerve injury, mainly by checking the expression changes of inflammation factors in the short-stage and the differences in the recovery of the injured sciatic nerve in the long-stage...
February 2018: International Immunopharmacology
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