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Xiuquan Shi, Tao Wang, Chan Nie, Haiyan Wang, Lirong Luo, Yonghong Qi, Zhixia Jiang
Falls are the top one type in all unintentional injuries. In this study, we aim to explore the epidemiological characteristics of falls and assess the intervention effect. Our research had interviewed 2854 rural children in southwest China. Then, we used School-Family-Individual (SFI) comprehensive education model to conduct an intervention among 1506 children and follow up them for one year. The changes in injury knowledge and incidence rate before and after intervention were compared. We found the fall injury was 37...
May 24, 2018: International Journal of Injury Control and Safety Promotion
Laura E Jennings, Matthias Schiedel, David S Hewings, Sarah Picaud, Corentine M C Laurin, Paul A Bruno, Joseph P Bluck, Amy R Scorah, Larissa See, Jessica K Reynolds, Mustafa Moroglu, Ishna N Mistry, Amy Hicks, Pavel Guzanov, James Clayton, Charles N G Evans, Giulia Stazi, Philip C Biggin, Anna K Mapp, Ester M Hammond, Philip G Humphreys, Panagis Filippakopoulos, Stuart J Conway
Ligands for the bromodomain and extra-terminal domain (BET) family of bromodomains have shown promise as useful therapeutic agents for treating a range of cancers and inflammation. Here we report that our previously developed 3,5-dimethylisoxazole-based BET bromodomain ligand (OXFBD02) inhibits interactions of BRD4(1) with the RelA subunit of NF-κB, in addition to histone H4. This ligand shows a promising profile in a screen of the NCI-60 panel but was rapidly metabolised (t½  = 39.8 min). Structure-guided optimisation of compound properties led to the development of the 3-pyridyl-derived OXFBD04...
May 15, 2018: Bioorganic & Medicinal Chemistry
Hakan Törer, Elif Burcu Aydın, Mustafa Kemal Sezgintürk
In this study we designed an ultrasensitive electrochemical immunosensor for RACK 1 detection using 11-cyanoundecyltrimethoxysilane (11-CUTMS) as a immobilization matrix to immobilize biorecognition element. The used silane agent (11-CUTMS) provides a favorable platform for efficient loading of anti-RACK 1 antibody. The effective loading of the biorecognition element on the 11-CUTMS matrix was monitored by scanning electron microscopy (SEM), atomic force microscopy (AFM) images and fourier transform infrared spectroscopy (FTIR) spectra...
September 18, 2018: Analytica Chimica Acta
Felix Schell, Andrey E Boguslavskiy, Claus Peter Schulz, Serguei Patchkovskii, Marc J J Vrakking, Albert Stolow, Jochen Mikosch
We study the Strong-Field Ionization (SFI) of the hydrocarbon 1-butene as a function of wavelength using photoion-photoelectron covariance and coincidence spectroscopy. We observe a striking transition in the fragment-associated photoelectron spectra: from a single Above Threshold Ionization (ATI) progression for photon energies less than the cation D0-D1 gap to two ATI progressions for a photon energy greater than this gap. For the first case, electronically excited cations are created by SFI populating the ground cationic state D0, followed by sequential post-ionization excitation...
May 18, 2018: Physical Chemistry Chemical Physics: PCCP
Kamran Siddiqi, Rumana Huque, Mona Kanaan, Farid Ahmed, Tarana Ferdous, Sarwat Shah, Cath Jackson, Steve Parrott, Jasjit S Ahluwalia, Aziz Sheikh
Introduction: Children exposed to second-hand smoke (SHS) are at increased risk of respiratory illnesses. We piloted a Smoke Free Intervention (SFI) and trial methods before investigating its effectiveness and cost-effectiveness in primary school children. Methods: In a pilot cluster randomised controlled-trial in Bangladesh, primary schools were allocated to usual education (control) or SFI, using minimisation. Year-5 children were recruited. Masking treatment allocation was not possible...
May 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Hamid Reza Mokhtarinia, Azadeh Hosseini, Azam Maleki-Ghahfarokhi, Charles Philip Gabel, Majid Zohrabi
BACKGROUND: There are various instruments and methods to evaluate spinal health and functional status. Whole-spine patient reported outcome (PRO) measures, such as the Spine Functional Index (SFI), assess the spine from the cervical to lumbo-sacral sections as a single kinetic chain. The aim of this study was to cross-culturally adapt the SFI for Persian speaking patients (SFI-Pr) and determine the psychometric properties of reliability and validity (convergent and construct) in a Persian patient population...
May 15, 2018: Health and Quality of Life Outcomes
Mehrnaz Moattari, Homa Mohseni Kouchesfehani, Gholamreza Kaka, Seyed Homayoon Sadraie, Majid Naghdi
BACKGROUND: Peripheral nerve damages are a relatively common type of the nervous system injuries. Although peripheral nerves show some capacity of regeneration after injury, the extent of regeneration is not remarkable. The present study aimed to evaluate the effect of NGF treated mesenchymal stem cells on regeneration of transected sciatic nerve. MATERIALS AND METHODS: In this experimental study, forty-two male Wistar.rats (180-200 g) were randomly divided into 6 groups (n = 7) including control, Membrane + Cell (Mem + Cell), NGF group, NGF + Cell group, NGF + Mem group and NGF + Mem + Cell group...
April 5, 2018: Journal of Cranio-maxillo-facial Surgery
Mehrnaz Moattari, Homa Kouchesfehani, GholamReza Kaka, Homayoon Sadraie, Majid Naghdi
AIM: One of the major injuries of the nervous system is that of peripheral nerves. Although peripheral nerves show some capacity of regeneration after injury, the extent of regeneration is not remarkable. The present study aimed to evaluate the regeneration of the transected sciatic nerve by membrane and betamethasone in rats. MATERIAL AND METHODS: In this study twenty-eight adult male rats were divided into four equal groups including 1. Control group (Ctrl); 2...
June 9, 2017: Turkish Neurosurgery
Héla Toumi, Moncef Boumaiza, Maurice Millet, Claudemir Marcos Radetski, Baba Issa Camara, Vincent Felten, Jean-François Masfaraud, Jean-François Férard
We studied the combined acute effect (i.e., after 48 h) of deltamethrin (a pyrethroid insecticide) and malathion (an organophosphate insecticide) on Daphnia magna. Two approaches were used to examine the potential interaction effects of eight mixtures of deltamethrin and malathion: (i) calculation of mixture toxicity index (MTI) and safety factor index (SFI) and (ii) response surface methodology coupled with isobole-based statistical model (using generalized linear model). According to the calculation of MTI and SFI, one tested mixture was found additive while the two other tested mixtures were found no additive (MTI) or antagonistic (SFI), but these differences between index responses are only due to differences in terminology related to these two indexes...
April 19, 2018: Environmental Science and Pollution Research International
Zhen Wang, Jianhui Wu, Ang Lv, Chengpeng Li, Zhongwu Li, Min Zhao, Chunyi Hao
This study sought to evaluate the infiltration tendency of retroperitoneal liposarcoma (RPLS) from a new pathological angle by exploring the infiltration characteristics, which could provide helpful information to facilitate surgical decision-making and prognosis prediction. Concurrently, we aim to identify significant indicators of infiltration. A total of 61 consecutive patients with RPLS at our institution were retrospectively analyzed. All patients received extended surgery. The tumor infiltration characteristics and influencing factors were studied based on the pathological diagnosis...
April 15, 2018: Bioscience Trends
A L Silva, T J DeVries, L O Tedeschi, M I Marcondes
There is a lack of studies that provide models or equations capable of predicting starter feed intake (SFI) for milk-fed dairy calves. Therefore, a multi-study analysis was conducted to identify variables that influence SFI, and to develop equations to predict SFI in milk-fed dairy calves up to 64 days of age. The database was composed of individual data of 176 calves from eight experiments, totaling 6426 daily observations of intake. The information collected from the studies were: birth BW (kg), SFI (kg/day), fluid milk or milk replacer intake (MI; l/day), sex (male or female), breed (Holstein or Holstein×Gyr crossbred) and age (days)...
April 16, 2018: Animal: An International Journal of Animal Bioscience
Luana Gabriel de Souza, Alexandre Márcio Marcolino, Heloyse Uliam Kuriki, Elaine Cristina Dalazen Gonçalves, Marisa de Cássia Registro Fonseca, Rafael Inácio Barbosa
To analyze the effect of photobiomodulation and dexamethasone on nerve regeneration after a sciatic nerve crushing model. Twenty-six Swiss mice were divided into the following groups: naive; sham; injured, low-level laser therapy (LLLT) (660 nm, 10 J/cm2 , 0.6 J, 16.8 J total energy emitted during the 28 days of radiation, 20 s, for 28 days); dexamethasone (Dex) (local injection of 2 mg/kg for 10 consecutive days); and LLLT group associated with Dex (LLLT/Dex), with the same parameters of the other groups...
April 2, 2018: Lasers in Medical Science
Dan Wu
If the scalp potential signals, the electroencephalogram (EEG), are due to neural "singers" in the brain, how could we listen to them with less distortion? One crucial point is that the data recording on the scalp should be faithful and accurate, thus the choice of reference electrode is a vital factor determining the faithfulness of the data. In this study, music on the scalp derived from data in the brain using three different reference electrodes were compared, including approximate zero reference-reference electrode standardization technique (REST), average reference (AR), and linked mastoids reference (LM)...
2018: Frontiers in Neuroscience
Michael Ghijsen, Griffin R Lentsch, Sylvain Gioux, Matthew Brenner, Anthony J Durkin, Bernard Choi, Bruce J Tromberg
The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive disease. We present and validate a noncontact method for quantitatively mapping tMRO2 over a wide, scalable field of view at 16  frames  /  s. We achieve this by developing a dual-wavelength, near-infrared coherent spatial frequency-domain imaging (cSFDI) system to calculate tissue optical properties (i.e., absorption, μa, and reduced scattering, μs', parameters) as well as the speckle flow index (SFI) at every pixel...
March 2018: Journal of Biomedical Optics
Zhu-Jun Mao, Quan-Long Zhang, Jia Shang, Ting Gao, Wen-Jun Yuan, Lu-Ping Qin
Shenfu Injection (SFI) is a classical Chinese medicine used to treat heart failure. Our previous study demonstrated that miRNAs underwent changes in rats with myocardial hypertrophy induced by abdominal aortic constriction. Interestingly, there was a significant change in miR-19a-3p, whose target gene is known to be associated with MEF2 signaling. However, whether and how SFI regulates miR-19a-3p in the treatment of myocardial hypertrophy has not been investigated. The purpose of the present study was to investigate the regulatory effect of SFI on miR-19a-3p in MEF2 signaling in the rat hypertrophic myocardium...
March 16, 2018: Scientific Reports
Laurence Klotz, Andrew Loblaw, Robert Siemens, Paul Ouellette, Anil Kapoor, Marlene Kebabdjian, Liying Zhang, Fred Saad
PURPOSE: We applied a range of induction durations of between 3 and 12 months in men initiating intermittent androgen deprivation therapy. MATERIALS AND METHODS: We determined whether the duration of induction androgen deprivation therapy would influence the duration of the off treatment interval and the recovery of serum testosterone. MANEUVER: This was a prospective, randomized, open label study. Men with biochemical recurrence after local therapy for prostate cancer and a negative bone scan were randomized to between 4 and 10 months of monthly degarelix...
March 11, 2018: Journal of Urology
Juan Hu, Jinggui Wu, Xiaojing Qu, Jianming Li
The objective of this work was to evaluate the variation in the amount and structure of humic acid (HA) after the application of organic wastes (OWs) in semiarid soil under plastic mulched drip irrigation, measured by elemental composition, excitation-emission matrix (EEM) fluorescence, and carbon 13 nuclear magnetic resonance (13 C CPMAS NMR). The experiment involved chemical fertilizer combined with chicken manure (CM), sheep manure (SM), maize straw (MS), fodder grass (FG), and tree leaves (TL), while chemical fertilizer only was used as control (CK)...
June 2018: Chemosphere
Ali Eren, Hakan Atalar, Cemile Merve Seymen, Ferda Alpaslan Pınarlı, Gulnur Take Kaplanoglu, Sacit Turanlı
PURPOSE: The aim of this study was to define a sutureless peripheral nerve repair technique with a vein graft and bone marrow-derived stem cells (BMSC) and compare it to epineural repair. MATERIALS AND METHODS: Thirty Wistar Albino rats were divided into five groups evenly. In the control group (C), epineural repair was performed. In the SV (suture + vein) and MSV (BMSC + suture + vein) groups, epineural repair was wrapped with a vein graft. In the V (vein) and MV (vein + BMSC) groups, sutureless repair using a vein graft was performed by taking sutures away from the regeneration site...
March 1, 2018: Microsurgery
Edyta Olakowska, Wiesław Marcol, Adam Właszczuk, Izabella Woszczycka-Korczyńska, Joanna Lewin-Kowalik
BACKGROUND: Spinal cord injury (SCI) is an important cause of impairment of sensory and motor nerve function. It has been shown that free-radical species play an important role in the pathogenesis of acute tissue trauma after SCI. There are no proven pharmacological therapies that provide neuroprotection and stimulate axonal growth after trauma. OBJECTIVES: The aim of this study was to investigate the neuroprotective effect of N-acetylcysteine (NAC) on the regeneration of spinal cord injuries in rats...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mingxing Zhang, Ye Zhang, Yuhong Bian, Hui Fu, Ying Xu, Yi Guo
BACKGROUND: Recently, application of electroacupuncture (EA) to stimulate nerve regeneration has become a mainstream treatment in clinical rehabilitation and related basic research, but the efficacy of long-term stimulation has not been confirmed. OBJECTIVE: To evaluate the influence of long term EA on peripheral nerve injury (PNI) from multiple angles. METHOD: Twenty-four rats were divided into three groups: control, PNI and PNI+EA. In the latter two groups, PNI was modelled by transection followed by re-anastomosis of thesciatic nerve...
February 7, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
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