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Venkatesh Aithal, Joseph Kei, Carlie Driscoll, Michio Murakoshi, Hiroshi Wada
OBJECTIVE: International Journal of Audiology To study the developmental characteristics of sweep frequency impedance (SFI) measures in healthy infants from birth to 6 months. DESIGN: All infants were assessed using high-frequency tympanometry (HFT), distortion product otoacoustic emission (DPOAE) and SFI tests. SFI measures consisted of measurement of resonance frequency (RF) and mobility (ΔSPL) of the outer and middle ear. A mixed model analysis of variance was applied to the SFI data to examine the effect of age on RF and ΔSPL...
October 26, 2016: International Journal of Audiology
Pan Li, Bin Lv, Xiaoqing Jiang, Ting Wang, Xianghui Ma, Nianwei Chang, Xiaoying Wang, Xiumei Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Shenfu injection (SFI) is a commercial medicinal product approved by the China Food and Drug Administration that is widely used in the treatment of stroke and coronary heart disease. However, the material basis and the mechanism of SFI are not fully understood. AIM OF THE STUDY: With network pharmacology analysis, our research committed to identify the anti-inflammatory ingredients and mechanism of SFI by combining high-throughput screening...
October 19, 2016: Journal of Ethnopharmacology
Pedro M Lourenço, José A Alves, Jeroen Reneerkens, Ah Jelle Loonstra, Peter M Potts, José P Granadeiro, Teresa Catry
Many migratory bird species show high levels of site fidelity to their wintering sites, which confers advantages due to prior knowledge, but may also limit the ability of the individual to move away from degrading sites or to detect alternative foraging opportunities. Winter site fidelity often varies among age groups, but sexual differences have seldom been recorded in birds. We studied a population of individually colour-marked sanderlings wintering in and around the Tejo estuary, a large estuarine wetland on the western coast of Portugal...
2016: PeerJ
Toni Luokkala, Jorma Ryhänen, Juha Näpänkangas, Teemu V Karjalainen
Background: The repair of a segmental peripheral nerve injury is a clinical challenge. Several studies have been performed to determine superior methods for overcoming nerve gaps. The purpose of this study was to investigate if the inside-out slided epineurium of the distal segment of an injured nerve can serve as a conduit to bridge a short nerve defect (10 mm). Methods: Nineteen sciatic nerves in Sprague-Dawley rats were transected, and a 10-mm gap was left between the ends. A section of distal epineurium was pulled inside out to bridge the gap...
September 2016: Hand: Official Journal of the American Association for Hand Surgery
Camila Oliveira Goulart, Daniella de Freitas Pereira Ângelo Durço, Lítia Alves de Carvalho, Júlia Teixeira Oliveira, Lucinéia Alves, Leny A Cavalcante, Ana Maria Blanco Martinez
The regenerative potential of the peripheral nervous system (PNS) is widely known, but functional recovery, particularly in humans, is seldom complete. Therefore, it is necessary to resort to strategies that induce or potentiate the PNS regeneration. Our main objective was to test the effectiveness of Olfactory Ensheathing Cells (OEC) transplantation into a biodegradable conduit as a therapeutic strategy to improve the repair outcome after nerve injury. Sciatic nerve transection was performed in C57BL/6 mice; proximal and distal stumps of the nerve were sutured into the collagen conduit...
November 1, 2016: Brain Research
Seyed Homayoon Sadraie, Kazem Parivar, Farzaneh Arabi, Mehrnaz Moattari, Gholamreza Kaka, Korosh Mansouri
BACKGROUND: The aim of this study was to determine the effects of amniotic membrane impregnated with betamethasone on regeneration of transected sciatic nerve injury in adult albino Wister rats. METHODS: In this research, 42 male adult rats were divided into six equal groups. 1) Normal (intact) group: healthy rats without any injury; 2) CONTROL GROUP: sciatic nerve was cut and sutured; 3) Sham group: 0.2 mL culture medium was injected on the epineurium in the injury; 4) Amniotic membrane group (AM): Acellular amniotic membrane was used around the damaged sciatic nerve; 5) Betamethasone group (B): 0...
September 2016: Archives of Iranian Medicine
Timothy L T Siu, Kainu Lin
OBJECTIVE: The concept of minimally invasive tubular discectomy is based on precise placement of the retractor over the surgical target to minimize collateral tissue trauma. For far lateral disc herniation, the junction between the pars and the transverse process has generally been adopted as the target for facilitating early nerve root exposure; however, this may limit access to the disc space and increase the risks of iatrogenic neuralgia. An alternative approach to help address these issues involving docking the retractor caudally directly over the disc space with the aid of a microscope is here proposed...
August 2016: Orthopaedic Surgery
Qin Yin, Cai-Jun Wu, Jun Yang, Chen-Chen Hang, Chun-Sheng Li
OBJECTIVE: To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). METHODS: Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC)...
September 10, 2016: Chinese Journal of Integrative Medicine
Wei Gu, Qian Zhang, Chun-Sheng Li
OBJECTIVE: To investigate whether Shen-Fu Injection (, SFI) reduces post-resuscitation immune dysfunction in a porcine model of cardiac arrest by modulating apoptosis of regulatory T lymphocytes (Treg) in the spleen. METHODS: After 8-min untreated ventricular fibrillation and 2-min basic life support, 24 pigs were divided into 3 groups with a random number table, i.e. SFI group, epinephrine (EP) group, and saline (SA) group (8 in each group), which received central venous injection of SFI (1...
September 2016: Chinese Journal of Integrative Medicine
Zhiyun Wang, Jianping Wang, Andreas Maercker
BACKGROUND: Insight into user adherence to Web-based intervention programs and into its relationship to intervention effect is needed. OBJECTIVE: The objective of this study was to examine use of a Web-based self-help intervention program, the Chinese version of My Trauma Recovery (CMTR), among Chinese traumatized individuals, and to investigate the relationship between program use and user characteristics before the intervention and change in outcomes after the intervention and at 3-months' follow-up...
September 9, 2016: Journal of Medical Internet Research
Dania Comparcini, Marco Tomietto, Valentina Simonetti, Francesca Zambri, Giancarlo Cicolini
AIM: To explore the first year midwifery students' clinical learning experience and satisfaction; to analyse the association between students' satisfaction and individual motivation. METHOD: The multicentre cross-sectional study was carried out in four Italian midwifery degree courses. A convenience sample of 61 students filled out the Italian version of the "Clinical Learning Environment and Supervision plus Nurse Teacher (CLES+T) scale" after the conclusion of their first clinical placement...
April 2016: Professioni Infermieristiche
Mohammad-Bagher Ghayour, Arash Abdolmaleki, Morteza Behnam-Rassouli
AIM: Following severe peripheral nerve injury (PNI), regeneration is often insufficient and functional recovery is incomplete. In this regard, glutamate NMDA receptor antagonist such as Memantine have been shown to have neuroprotective effects. We evaluated the effects of Memantine against sciatic nerve crush injury in male Wistar Rats. MATERIAL AND METHODS: Memantine or vehicle was given parenteraly to rats for 7 days postoperative. In Memantine treatment groups, a single dose of agent (5 and 10 mg/kg) was administered daily...
February 5, 2016: Turkish Neurosurgery
Gholam Hossein Farjah, Mohammad Amin Dolatkhah, Bagher Pourheidar, Behnam Heshmatian
AIM: The aim of this study was to evaluate the effect of cerebro-spinal fluid (CSF) in nerve regeneration across the collagen guide channel in comparison with autograft. MATERIAL AND METHODS: Forty adult male rats (250-300g) were randomized into (1) collagen channel + CSF, (2) collagen channel + normal saline (NS), (3) autograft, and (4) sham surgery groups. The left sciatic nerve was exposed and a 10mm nerve segment was cut and removed. In the collagen groups, the proximal and distal cuts ends of sciatic nerve were telescoped into the nerve guides and CSF or NS injected into collagen conduit...
December 28, 2015: Turkish Neurosurgery
Juan DU, Brian Chi Yan Cheng, Xiu-Qiong Fu, Tao Su, Ting Li, Hui Guo, Su-Mei Li, Jin-Feng Wu, Hua Yu, Wen-Hua Huang, Hui Cao, Zhi-Ling Yu
ETHNOPHARMACOLOGICAL RELEVANCE: A modern agent Shenqi Fuzheng Injection (SFI), prepared from Codonopsis Radix and Astragali Radix, has been commonly used as a supplementary therapy for cancers including melanoma. This agent was derived from a formula documented in the "National Collection of Chinese Medicine Prescriptions". The formula has long been used as a remedy for Qi deficiency that is closely associated with cancer-related fatigue and poor quality of life. However, the antimelanoma mechanisms of SFI remain unclear...
August 23, 2016: Journal of Ethnopharmacology
Marta Rubio-Codina, M Caridad Araujo, Orazio Attanasio, Pablo Muñoz, Sally Grantham-McGregor
In low- and middle-income countries (LIMCs), measuring early childhood development (ECD) with standard tests in large scale surveys and evaluations of interventions is difficult and expensive. Multi-dimensional screeners and single-domain tests ('short tests') are frequently used as alternatives. However, their validity in these circumstances is unknown. We examined the feasibility, reliability, and concurrent validity of three multi-dimensional screeners (Ages and Stages Questionnaires (ASQ-3), Denver Developmental Screening Test (Denver-II), Battelle Developmental Inventory screener (BDI-2)) and two single-domain tests (MacArthur-Bates Short-Forms (SFI and SFII), WHO Motor Milestones (WHO-Motor)) in 1,311 children 6-42 months in Bogota, Colombia...
2016: PloS One
S J Lv, D P Lai, X Wei, Q Yan, J M Xia
OBJECTIVE: The purpose of this study is to investigate the effect of Shenfu injection (SFI) on the tumor necrosis factor-α (TNF-α) and the interleukin (IL-6, IL-8, IL-10) of elderly patients who suffered from severe pneumonia. METHODS: From June 2012 to September 2014, we performed in our department 89 cases of elderly patients with severe pneumonia. These patients were randomly divided into two groups: the treatment group (45 cases) and the control group (44 cases)...
July 25, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Anne Hosmalin, Catherine Sautès-Fridman, Michel Fougereau, Hans Yssel, Alain Fischer
No abstract text is available yet for this article.
July 2016: European Journal of Immunology
Joerg U Schmohl, Tina Nuebling, Julia Wild, Tanja Kroell, Lothar Kanz, Helmut R Salih, Helga Schmetzer
Costimulatory ligands (COLs) and their receptors (COR) regulate immune reactions and cellular survival and might be relevant in acute myeloid leukemia (AML). This study evaluated the clinical relevance of 4-1BBL, glucocorticoid-induced TNFR-related protein (GITR) and ligand (GITRL), CD80, and CD86 in case of expression on AML blasts. 98 patients were evaluated at initial diagnosis. Immunophenotypically evaluated specific fluorescence index (SFI) levels of COR and COL on blasts were correlated with morphological, cytogenetic, and several prognostic parameters...
July 7, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Daniel J Schober, Leah Carpenter, Venita Currie, Amy L Yaroch
BACKGROUND: The purpose of this evaluation was to examine the effects of the LiveWell@School Food Initiative (LW@SFI), a Colorado-based childhood obesity prevention program that partners with school districts to enable them to serve more scratch cooked foods through culinary training, action planning, and equipment grants. METHODS: This evaluation used a quasi-experimental design that examined menu cycles prior to entering the LW@SFI and approximately 1 year later...
August 2016: Journal of School Health
Guangyong Yang, Haitao Guo, Ximing Liu, Guangzhi He, Weiyi Tian, Kun Cai, Ping Wang, Wenjia Wang
Objective To construct the recombinant human interleukin 4 receptor (rhIL-4R) single-chain Fv (scFv) antibody library by phage display technique to obtain the anti-IL-4R scFv clones selected from the library. Methods Total RNA was extracted from splenocytes of the BALB/c mice immunized with rhIL-4R. Complementary DNA fragments of variable heavy (VH) and variable light (VL) chains of the antibodies were prepared by reverse transcription PCR and assembled into scFv by splice overlap extension PCR (SOE-PCR). Both scFv and the pCANTAB5E vector were respectively double-digested with restriction endonuclease Sfi I and Not I, connected with T4 ligase, and then transformed into the competent cells E...
June 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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