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https://www.readbyqxmd.com/read/29142239/differential-overexpression-of-serpina3-in-human-prion-diseases
#1
S Vanni, F Moda, M Zattoni, E Bistaffa, E De Cecco, M Rossi, G Giaccone, F Tagliavini, S Haïk, J P Deslys, G Zanusso, J W Ironside, I Ferrer, G G Kovacs, G Legname
Prion diseases are fatal neurodegenerative disorders with sporadic, genetic or acquired etiologies. The molecular alterations leading to the onset and the spreading of these diseases are still unknown. In a previous work we identified a five-gene signature able to distinguish intracranially BSE-infected macaques from healthy ones, with SERPINA3 showing the most prominent dysregulation. We analyzed 128 suitable frontal cortex samples, from prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD (iCJD) n = 11, sporadic CJD (sCJD) n = 23, familial CJD (gCJD) n = 17, fatal familial insomnia (FFI) n = 9, Gerstmann-Sträussler-Scheinker syndrome (GSS)) n = 4), patients with Alzheimer disease (AD, n = 14) and age-matched controls (n = 30)...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29135720/clinical-outcome-following-total-joint-replacement-and-arthrodesis-for-hallux-rigidus-a-systematic-review
#2
Jasper Stevens, Robin T A L de Bot, Joris P S Hermus, Lodewijk W van Rhijn, Adhiambo M Witlox
BACKGROUND: Hallux rigidus is a common cause of foot pain in the elderly and has a negative impact on quality of life. Several operative treatment options are available for feet that are refractory to conservative treatment. Of these, total joint replacement and arthrodesis of the first metatarsophalangeal joint are the most commonly performed interventions. Nevertheless, it is still not known which intervention results in the best clinical outcome and the fewest complications. METHODS: PubMed/MEDLINE, Embase, and the Cochrane Library were systematically searched for studies assessing outcome with the American Orthopaedic Foot & Ankle Society-Hallux Metatarsophalangeal Interphalangeal (AOFAS-HMI) score, Foot Function Index (FFI), visual analog scale (VAS) for pain, or Short Form-36 (SF-36) in patients who underwent an arthrodesis or total joint replacement for the treatment of symptomatic hallux rigidus...
November 14, 2017: JBJS Reviews
https://www.readbyqxmd.com/read/29119956/-a-study-of-the-effective-psychotherapist-image-and-expectations-about-psychotherapy-among-the-employees-of-hazardous-occupations-policemen
#3
V A Agarkov, S A Bronfman, D Y Maltseva
BACKGRAUND: The objective of the present study was to estimate the expectations about psychotherapy in terms of social and medical rehabilitation among the employees of hazardous occupations suffering from the consequences of a psychological trauma. MATERIAL AND METHODS: A total of 100 subjects employed by various departments of the Russian Ministry of Internal Affairs (MIA) were recruited to participate in the study. Their age varied from 19 to 35 (mean 25.8±3...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29111452/extraversion-and-cardiovascular-responses-to-recurrent-social-stress-effect-of-stress-intensity
#4
Wei Lü, Wanying Xing, Brian M Hughes, Zhenhong Wang
The present study sought to establish whether the effects of extraversion on cardiovascular responses to recurrent social stress are contingent on stress intensity. A 2×5×1 mixed-factorial experiment was conducted, with social stress intensity as a between-subject variable, study phase as a within-subject variable, extraversion as a continuous independent variable, and cardiovascular parameter (HR, SBP, DBP, or RSA) as a dependent variable. Extraversion (NEO-FFI), subjective stress, and physiological stress were measured in 166 undergraduate students randomly assigned to undergo moderate (n=82) or high-intensity (n=84) social stress (a public speaking task with different levels of social evaluation)...
October 27, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29102897/the-hypothalamic-pituitary-thyroid-axis-and-personality-in-a-sample-of-healthy-subjects
#5
Aleksei Piskunov, Adela Fusté, Nadezhda Teryaeva, Aleksei Moshkin, José Ruiz
Thyroid hormones influence various brain pathologies, including psychiatric disorders. However, the relationship between these hormones and the psychological state in the normal, non-clinical population is poorly understood. We aimed to test whether serum levels of thyroid hormones are associated with personality in the healthy population. Thyrotropin (TSH), free T3 (FT4), total and free T4 (TT4 and FT4) concentrations were measured in the blood of 104 healthy participants (44% men) aged 18-59 (M=35±9). Personality traits were assessed using the revised short versions of the Temperament and Character Inventory (TCI-140) and the NEO Five-Factor Inventory (NEO-FFI)...
October 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29081702/translation-cultural-adaptation-and-validation-of-the-foot-function-index-revised-ffi-r
#6
Kelly Cristina Stéfani, Miguel Viana Pereira, Pedro Rizzi Oliveira, Paloma Yan Lam Wun
OBJECTIVE: The aim of this study was to translate, culturally adapt, and validate the "Foot Function Index - Revised" (FFI-R) for use in Brazilian Portuguese. METHODS: The scale was translated and administered (as recommended by Guillemin, 2000) to 52 patients in the postoperative period after foot and ankle surgery. Seven days after the initial assessment, the scale was readministered by a different interviewer. The data were entered into an Excel spreadsheet and analyzed using SPSS version 23...
September 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/29040277/personality-and-achievement-along-medical-training-evidence-from-a-cross-lagged-analysis
#7
Isabel Lourinho, Maria Amélia Ferreira, Milton Severo
INTRODUCTION: Evidence on personality traits change implies it should be studied as an outcome and not only as an explanatory effect. Therefore, we aimed to assess how personality and academic achievement sway each other. Three cohorts of medical students (n = 181) comprised of school leavers and graduates, completed NEO-FFI when admitted (baseline) and later on medical training (follow-up). Previous achievement was measured as mean scores on national school examinations, and academic achievement as medical course average...
2017: PloS One
https://www.readbyqxmd.com/read/29033795/cellular-mechanisms-of-cortisol-induced-changes-in-mauthner-cell-excitability-in-the-startle-circuit-of-goldfish
#8
Daniel R Bronson, Thomas Preuss
Predator pressure and olfactory cues (alarm substance) have been shown to modulate Mauthner cell (M-cell) initiated startle escape responses (C-starts) in teleost fish. The regulation of such adaptive responses to potential threats is thought to involve the release of steroid hormones such as cortisol. However, the mechanism by which cortisol may regulate M-cell excitability is not known. Here, we used intrasomatic, in vivo recordings to elucidate the acute effects of cortisol on M-cell membrane properties and sound evoked post-synaptic potentials (PSPs)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29031320/burnout-and-its-relationship-with-personality-factors-in-oncology-nurses
#9
Emilia I De la Fuente-Solana, José L Gómez-Urquiza, Gustavo R Cañadas, Luis Albendín-García, Elena Ortega-Campos, Guillermo A Cañadas-De la Fuente
PURPOSE: To assess burnout levels in oncology nurses, to evaluate at what stage of burnout suffering they are and to analyze the relationship between burnout with personality factors. METHOD: A quantitative, observational, cross-sectional multicenter study was done. Oncology nurses (n = 101) from the Andalusian Health Service (Andalusia, Spain) were included. The main variables were personality factors, assessed with the NEO-FFI questionnaire, anxiety and depression, assessed with the Educational-Clinical Questionnaire: Anxiety and Depression, and burnout, evaluated with the Maslach Burnout Inventory...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29026933/measurement-properties-of-the-most-commonly-used-foot-and-ankle-specific-questionnaires-the-ffi-faos-and-faam-a%C3%A2-systematic-review
#10
REVIEW
I N Sierevelt, R Zwiers, W Schats, D Haverkamp, C B Terwee, P A Nolte, G M M J Kerkhoffs
PURPOSE: In the foot and ankle literature, a wide range of patient-reported outcome measures (PROMs) is used, however, consensus as to which PROMs are preferred is lacking. Selection of a PROM is among other reasons, often based on measurement properties without considering the methodological quality of the studies that evaluate these measurement properties. The aim of current study was first to identify the most frequently used foot and ankle-specific PROMs in recent orthopaedic foot and ankle literature, and second to conduct a systematic review to synthesize and critically appraise the measurement properties of these PROMS...
October 12, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29026929/the-outcome-of-proximal-fifth-metatarsal-fractures-redefining-treatment-strategies
#11
P Monteban, J van den Berg, J van Hees, S Nijs, H Hoekstra
BACKGROUND: To optimize the treatment strategy and reduce treatment costs of proximal fifth metatarsal fractures, clinical and patient-reported outcome, and its determinants were addressed. METHODS: A retrospective adult cohort study including 152 proximal fifth metatarsal fractures: 121 nonoperatively and 31 operatively treated. In the operative group, 21 were zone 1 and 10 zone 2 fractures. Median follow-up was 37.5 (IQR 20.8-52.3) months with a minimal follow-up of 6 months...
October 12, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28975843/long-term-follow-up-of-capsular-interposition-arthroplasty-for-hallux-rigidus
#12
Ettore Vulcano, Andy L Chang, David Solomon, Mark Myerson
BACKGROUND: Capsular interposition arthroplasty is a joint- and motion-sparing procedure that has been shown as an effective alternative to fusion. This study aimed to evaluate patient function and satisfaction after long-term follow-up. METHODS: Sixty-four patients were treated with capsular interposition arthroplasty for hallux rigidus by the senior author performed between February 1998 and July 2011. Twenty-two patients could not be reached for follow-up and were thus excluded from the analysis...
October 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28956109/hallux-valgus-in-a-random-population-in-spain-and-its-impact-on-quality-of-life-and-functionality
#13
Cristina González-Martín, Francisco Alonso-Tajes, Sergio Pérez-García, María Teresa Seoane-Pillado, Sonia Pértega-Díaz, Estefanía Couceiro-Sánchez, Rocío Seijo-Bestilleiro, Salvador Pita-Fernández
The aim of this study was to determine the prevalence of Hallux valgus (HV) and the association between the presence thereof and quality of life, dependence for basic and instrumental activities of daily living and foot function. Prevalence study was carried out in a random population sample (n = 1837) (α = 0.05; Precision = ±2.2%). Informed consent and ethical review board were obtained (code 2008/264). We studied anthropometric variables, Charlson Comorbidity Index, function and state of foot [Foot Function index (FFI), Foot Health Status Questionnaire (FHSQ)], quality of life (SF-36), and dependence for activities of daily living (Barthel and Lawton index)...
November 2017: Rheumatology International
https://www.readbyqxmd.com/read/28955664/academic-performance-in-iranian-medical-students-during-the-pre-clinical-stage
#14
Farnoush Davoudi, Shooka Esmaeeli, Masoud AhmadzadAsl, Marzieh Nojomi
Background: Better understanding of factors associated with medical school performance is necessary to improve admission processes and to help students succeed in their career. This study follows a group of Iranian med students during their first 2.5 years of medical education, to evaluate their academic success in accordance with their demographic, cognitive and non-cognitive characteristics. Methods: 143 of 200 matriculants of Iran University of Medical Sciences medical school in 2010, were followed for 5 consecutive semesters of the preclinical stage...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28918441/long-lasting-subjective-effects-of-lsd-in-normal-subjects
#15
Yasmin Schmid, Matthias E Liechti
RATIONALE: Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences, with reportedly long-lasting effects on subjective well-being and personality. METHODS: We investigated the lasting effects of a single dose of LSD (200 μg) that was administered in a laboratory setting in 16 healthy participants. The following outcome measures were assessed before and 1 and 12 months after LSD administration: Persisting Effects Questionnaire (PEQ), Mysticism Scale (MS), Death Transcendence Scale (DTS), NEO-Five Factor Inventory (NEO-FFI), and State-Trait Anxiety Inventory (STAI)...
September 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28843716/outcome-following-osteosynthesis-or-primary-arthrodesis-of-calcaneal-fractures-a-cross-sectional-cohort-study
#16
Siem A Dingemans, Sjoerd T Meijer, Manouk Backes, Vincent M de Jong, Jan S K Luitse, Tim Schepers
BACKGROUND: Calcaneal fractures are uncommon and have a substantial impact on hindfoot function and quality of life. Several surgical treatment options are available; both in surgical approach and type of operation. The aim of this study was to compare functional outcome and quality of life following ORIF and primary arthrodesis. Furthermore, predictors of worse functional outcome were explored. METHODS: A retrospective cross-sectional cohort study was performed in patients with surgical fixation of a calcaneal fracture with a minimum follow-up of 18 months...
August 18, 2017: Injury
https://www.readbyqxmd.com/read/28820834/super-thin-scip-flap-for-reconstruction-of-subungual-melanoma-aesthetic-functional-surgery
#17
Kyeong-Tae Lee, Bo Young Park, Eun-Ji Kim, Jung-Han Kim, Kee-Taek Jang, Sang-Hee Choi, Dong-Youn Lee, Goo-Hyun Mun
BACKGROUND: This study aimed to use a super-thin, free superficial circumflex iliac artery perforator (SCIP) flap in the functional surgery for treating subungual melanoma and to evaluate its outcomes. METHODS: Forty-one patients with primary subungual melanoma of ≤ 2-mm thickness who were treated with functional surgery were prospectively enrolled. Following oncologic resection, a thin SCIP flap was harvested along the trans-superficial fat layer and transferred to the defect with further thinning by primary defatting...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28814578/genetic-human-prion-disease-modelled-in-prp-transgenic-drosophila
#18
Alana M Thackray, Alzbeta Cardova, Hanna Wolf, Lydia Pradl, Ina Vorberg, Walker S Jackson, Raymond Bujdoso
Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrP(Sc), an abnormal isomer of the normal host protein PrP(C), in the brain of affected individuals. PrP(Sc) is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate prion formation and prion-induced neurotoxicity...
September 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28780212/administration-of-an-herbal-complex-jakyak-gamcho-tang-jgt-for-plantar-fasciitis-in-military-medical-service-a-case-report
#19
Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Ki-Ho Cho, Kyoung-Ho Shin
Plantar fasciitis is a common disease affecting the heel and plantar side of the foot. This condition can be improved within 6 months with conservative treatments such as stretching, nonsteroidal anti-inflammatory drugs (NSAIDs), extracorporeal shockwave therapy, and corticosteroid injection. However, soldiers need a faster and safer therapy for symptomatic relief to meet the requirements of their occupation. In this report, we reveal that Jakyak-Gamcho-Tang (JGT), an herbal complex, had a positive effect in a case series of 10 military patients with plantar fasciitis...
September 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28750599/the-influence-of-multiple-trials-and-computer-mediated-communication-on-collaborative-and-individual-semantic-recall
#20
Joanne M Hinds, Stephen J Payne
Collaborative inhibition is a phenomenon where collaborating groups experience a decrement in recall when interacting with others. Despite this, collaboration has been found to improve subsequent individual recall. We explore these effects in semantic recall, which is seldom studied in collaborative retrieval. We also examine "parallel CMC", a synchronous form of computer-mediated communication that has previously been found to improve collaborative recall [Hinds, J. M., & Payne, S. J. ( 2016 ). Collaborative inhibition and semantic recall: Improving collaboration through computer-mediated communication...
July 28, 2017: Memory
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