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https://www.readbyqxmd.com/read/28918441/long-lasting-subjective-effects-of-lsd-in-normal-subjects
#1
Yasmin Schmid, Matthias E Liechti
RATIONALE: Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences, with reportedly long-lasting effects on subjective well-being and personality. METHODS: We investigated the lasting effects of a single dose of LSD (200 μg) that was administered in a laboratory setting in 16 healthy participants. The following outcome measures were assessed before and 1 and 12 months after LSD administration: Persisting Effects Questionnaire (PEQ), Mysticism Scale (MS), Death Transcendence Scale (DTS), NEO-Five Factor Inventory (NEO-FFI), and State-Trait Anxiety Inventory (STAI)...
September 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28843716/outcome-following-osteosynthesis-or-primary-arthrodesis-of-calcaneal-fractures-a-cross-sectional-cohort-study
#2
Siem A Dingemans, Sjoerd T Meijer, Manouk Backes, Vincent M de Jong, Jan S K Luitse, Tim Schepers
BACKGROUND: Calcaneal fractures are uncommon and have a substantial impact on hindfoot function and quality of life. Several surgical treatment options are available; both in surgical approach and type of operation. The aim of this study was to compare functional outcome and quality of life following ORIF and primary arthrodesis. Furthermore, predictors of worse functional outcome were explored. METHODS: A retrospective cross-sectional cohort study was performed in patients with surgical fixation of a calcaneal fracture with a minimum follow-up of 18 months...
August 18, 2017: Injury
https://www.readbyqxmd.com/read/28820834/super-thin-scip-flap-for-reconstruction-of-subungual-melanoma-aesthetic-functional-surgery
#3
Kyeong-Tae Lee, Bo Young Park, Eun-Ji Kim, Jung-Han Kim, Kee-Taek Jang, Sang-Hee Choi, Dong-Youn Lee, Goo-Hyun Mun
BACKGROUND: This study aimed to use a super-thin, free superficial circumflex iliac artery perforator (SCIP) flap in the functional surgery for treating subungual melanoma and to evaluate its outcomes. METHODS: Forty-one patients with primary subungual melanoma of ≤ 2-mm thickness who were treated with functional surgery were prospectively enrolled. Following oncologic resection, a thin SCIP flap was harvested along the trans-superficial fat layer and transferred to the defect with further thinning by primary defatting...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28814578/genetic-human-prion-disease-modelled-in-prp-transgenic-drosophila
#4
Alana M Thackray, Alzbeta Cardova, Hanna Wolf, Lydia Pradl, Ina Vorberg, Walker S Jackson, Raymond Bujdoso
Inherited human prion diseases, such as FFI and familial CJD (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrPSc, an abnormal isomer of the normal host protein PrPC, in the brain of affected individuals. PrPSc is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate prion formation and prion-induced neurotoxicity. This will allow identification of possible therapeutic interventions for individuals with, or at risk from, genetic human prion disease...
August 16, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28780212/administration-of-an-herbal-complex-jakyak-gamcho-tang-jgt-for-plantar-fasciitis-in-military-medical-service-a-case-report
#5
Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Ki-Ho Cho, Kyoung-Ho Shin
Plantar fasciitis is a common disease affecting the heel and plantar side of the foot. This condition can be improved within 6 months with conservative treatments such as stretching, nonsteroidal anti-inflammatory drugs (NSAIDs), extracorporeal shockwave therapy, and corticosteroid injection. However, soldiers need a faster and safer therapy for symptomatic relief to meet the requirements of their occupation. In this report, we reveal that Jakyak-Gamcho-Tang (JGT), an herbal complex, had a positive effect in a case series of 10 military patients with plantar fasciitis...
July 4, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28750599/the-influence-of-multiple-trials-and-computer-mediated-communication-on-collaborative-and-individual-semantic-recall
#6
Joanne M Hinds, Stephen J Payne
Collaborative inhibition is a phenomenon where collaborating groups experience a decrement in recall when interacting with others. Despite this, collaboration has been found to improve subsequent individual recall. We explore these effects in semantic recall, which is seldom studied in collaborative retrieval. We also examine "parallel CMC", a synchronous form of computer-mediated communication that has previously been found to improve collaborative recall [Hinds, J. M., & Payne, S. J. ( 2016 ). Collaborative inhibition and semantic recall: Improving collaboration through computer-mediated communication...
July 28, 2017: Memory
https://www.readbyqxmd.com/read/28731965/functional-outcomes-post-lisfranc-injury-transarticular-screws-dorsal-bridge-plating-or-combination-treatment
#7
Simon Lau, Catherine Guest, Marcus Hall, Mark Tacey, Samuel Joseph, Andrew Oppy
OBJECTIVE: To identify whether transarticular screws, dorsal bridging plates or a combination of the 2 result in the best functional outcome after Lisfranc injury. DESIGN: Case series. SETTING: Level one trauma center. PATIENTS: Fifty patients who underwent surgical fixation of Lisfranc injuries over a 6-year period were retrospectively reviewed. INTERVENTION: One of 3 treatment arms: transarticular screw fixation alone, dorsal bridge plating alone or a combination of dorsal bridge and transarticular screw fixation...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28719083/subtypes-of-personality-and-locus-of-control-in-bariatric-patients-and-their-effect-on-weight-loss-eating-disorder-and-depressive-symptoms-and-quality-of-life
#8
Carolin Peterhänsel, Katja Linde, Birgit Wagner, Arne Dietrich, Anette Kersting
The present study subdivided personality types in a bariatric sample and investigated their impact on weight loss and psychopathology 6 and 12 months after surgery. One hundred thirty participants answered questionnaires on personality (NEO-FFI), 'locus of control' (IPC), depression severity (BDI-II), eating disorder psychopathology (EDE-Q), and health-related quality of life (HRQoL; SF-12). K-means cluster analyses were used to identify subtypes. Two subtypes emerged: an 'emotionally dysregulated/undercontrolled' cluster defined by high neuroticism and external orientation and a 'resilient/high functioning' cluster with the reverse pattern...
September 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28708946/sports-participation-functional-outcome-and-complications-after-ankle-arthrodesis-midterm-follow-up
#9
Yvonne R A Kerkhoff, Noël L W Keijsers, Jan Willem K Louwerens
BACKGROUND: Ankle arthrodesis provides satisfactory functional outcome based on basic daily activities, but information regarding more demanding tasks is limited. Also, studies reporting longer term survival and complication rates are sparse and concern small study populations. This study reports functional outcome with more focus on demanding tasks and sports and reports the mid- to long-term union and complication rates in a large study population. METHODS: Between 2005 and 2010, an ankle arthrodesis was performed on 185 ankles...
July 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28696588/feedforward-inhibition-is-randomly-wired-from-individual-granule-cells-onto-ca3-pyramidal-cells
#10
Máté Neubrandt, Viktor János Oláh, János Brunner, János Szabadics
Feedforward inhibition (FFI) between the dentate gyrus (DG) and CA3 sparsifies and shapes memory- and spatial navigation-related activities. However, our understanding of this prototypical FFI circuit lacks essential details, as the wiring of FFI is not yet mapped between individual DG granule cells (GCs) and CA3 pyramidal cells (PCs). Importantly, theoretically opposite network contributions are possible depending on whether the directly excited PCs are differently inhibited than the non-excited PCs. Therefore, to better understand FFI wiring schemes, we compared the prevalence of disynaptic inhibitory postsynaptic events (diIPSCs) between pairs of individually recorded GC axons or somas and PCs, some of which were connected by monosynaptic excitation, while others were not...
July 11, 2017: Hippocampus
https://www.readbyqxmd.com/read/28684309/personality-traits-and-dental-anxiety-in-self-reported-bruxism-a-cross-sectional-study
#11
J Montero, C Gómez-Polo
OBJECTIVES: The aim of this study was to investigate the association between psychological factors (Personality and Dental anxiety) with self-reported bruxism-related symptoms. METHODS: 526 subjects, over 18 years old and not seeking dental treatment, were recruited from the families and acquaintances of dental students from the University of Salamanca. Bruxism activity was estimated by means of a six-item questionnaire aimed at recording common bruxism-related symptoms and clenching/grinding awareness...
July 3, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28680397/a-comprehensive-analysis-of-the-correlations-between-resting-state-oscillations-in-multiple-frequency-bands-and-big-five-traits
#12
Shigeyuki Ikeda, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Ryuta Kawashima
Recently, the association between human personality traits and resting-state brain activity has gained interest in neuroimaging studies. However, it remains unclear if Big Five personality traits are represented in frequency bands (~0.25 Hz) of resting-state functional magnetic resonance imaging (fMRI) activity. Based on earlier neurophysiological studies, we investigated the correlation between the five personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI), and the fractional amplitude of low-frequency fluctuation (fALFF) at four distinct frequency bands (slow-5 (0...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28675316/the-relations-between-conscientiousness-and-mental-health-in-a-north-european-and-a-west-asian-culture
#13
Mohammad-Naghy Farahani, Reza Kormi-Nouri, Boele De Raad
BACKGROUND: The relationship between conscientiousness, mental health and mental illness has been an issue for the last two decades. AIMS: By using a dual model of mental health, the present study examined a non-linear relationship between conscientiousness and healthy or non-healthy symptoms in two different cultures. METHOD: Participants in this study were 296 Iranian and 310 Swedish university students (18-24 years of age). We used two different conscientiousness scales; the 12-item conscientiousness subscale of the NEO/FFI as an imported (etic) scale, and a 10-item Iranian conscientiousness scale as an indigenous (emic) and culture-dependent scale...
July 4, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28667199/predicting-death-over-8-years-in-a-prospective-cohort-of-hiv-infected-women-the-women-s-interagency-hiv-study
#14
Deborah R Gustafson, Qiuhu Shi, Susan Holman, Howard Minkoff, Mardge H Cohen, Michael W Plankey, Richard Havlik, Anjali Sharma, Stephen Gange, Monica Gandhi, Joel Milam, Donald R Hoover
OBJECTIVES: Predicting mortality in middle-aged HIV-infected (HIV+) women on antiretroviral therapies (ART) is important for understanding the impact of HIV infection. Several health indices have been used to predict mortality in women with HIV infection. We evaluated: (1) an HIV biological index, Veterans Aging Cohort Study (VACS); (2) a physical index, Fried Frailty Index (FFI); and (3) a mental health index, Center for Epidemiologic Studies-Depression (CES-D). Proportional hazards regression analyses were used to predict death and included relevant covariates...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28650749/comparative-effectiveness-of-radial-extracorporeal-shockwave-therapy-and-ultrasound-guided-local-corticosteroid-injection-treatment-for-plantar-fasciitis
#15
Sehriban Hocaoglu, Umit Erkan Vurdem, Mehtap Aykac Cebicci, Serap Tomruk Sutbeyaz, Zuhal Guldeste, Serap Gurek Yunsuroglu
BACKGROUND: We compared the long-term clinical and ultrasonographic effects of radial extracorporeal shockwave therapy (rESWT) versus ultrasound-guided corticosteroid injection treatment in patients with plantar fasciitis unresponsive to conservative therapy. METHODS: Seventy-two patients with unilateral plantar fasciitis were randomized to receive either rESWT (three times once per week) (n = 36) or corticosteroid treatment (a single 1-mL dose of betamethasone sodium plus 0...
May 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28647925/psychobehavioral-effects-of-meditation
#16
Mieczyslaw Pokorski, Anna Suchorzynska
Meditation is an increasingly popular psychobehavioral therapy. Various meditation techniques in use make it hard to objectively scrutinize the psychological benefits. Therefore, in this study we set out to examine the effects of two fundamentally different meditative techniques, Zazen, 'seated meditation', in which the body and mind are calmed, and Tai Chi, 'meditation in motion', based on energetic martial art performance. The aim was to compare the effects of both techniques on personality structure, emotional intelligence, mood, and coping with stress...
June 25, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28647522/functional-medium-term-results-after-autologous-matrix-induced-chondrogenesis-for-osteochondral-lesions-of-the-talus-a-5-year-prospective-cohort-study
#17
Oliver Gottschalk, Sebastian Altenberger, Sebastian Baumbach, Stefanie Kriegelstein, Florian Dreyer, Alexander Mehlhorn, Hubert Hörterer, Andreas Töpfer, Anke Röser, Markus Walther
Autologous matrix-induced chondrogenesis (AMIC) has gained popularity in the treatment of osteochondral lesions of the talus. Previous studies have presented promising short-term results for AMIC talar osteochondral lesion repair, a 1-step technique using a collagen type I/III bilayer matrix. The aim of the present study was to investigate the mid-term effects. The 5-year results of a prospective cohort study are presented. All patients underwent an open AMIC procedure for a talar osteochondral lesion. Data analysis included general demographic data, preoperative magnetic resonance imaging findings, intraoperative details, and German version of the Foot Function Index (FFI-D) scores preoperatively and at 1 and 5 years after surgery...
June 21, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633774/treatment-of-chronic-plantar-fasciitis-with-noninvasive-interactive-neurostimulation-a-prospective-randomized-controlled-study
#18
Cristina Razzano, Stefano Carbone, Massimiliano Mangone, M Raffaella Iannotta, Alessandro Battaglia, Valter Santilli
The initial treatment of plantar fasciitis should be conservative, with most cases responding to standard physiotherapy, nonsteroidal anti-inflammatory drugs (NSAIDs), heel pads, and stretching. In cases of chronic refractory symptoms, more invasive treatment could be necessary. Noninvasive interactive neurostimulation (NIN) is a form of electric therapy that works by locating areas of lower skin impedance. The objective of the present prospective randomized controlled study was to evaluate whether the use of NIN for chronic plantar fasciitis could result in greater improvement in a foot functional score, lower levels of reported pain, reduced patient consumption of NSAIDs, and greater patient satisfaction compared with electric shockwave therapy in patients without a response to standard conservative treatment...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28620158/clinical-features-and-sleep-analysis-of-chinese-patients-with-fatal-familial-insomnia
#19
Liyong Wu, Hui Lu, Xianling Wang, Jia Liu, Chaoyang Huang, Jing Ye, Cuijiang Li, Jun Lu, Yuping Wang, Jianping Jia, Shuqin Zhan
This study aimed to examine clinical features, sleep, abnormal sleep-wake transition and non-sleep disturbances as well as lab tests in Chinese fatal familial insomnia (FFI) subjects. Patients with confirmed clinical and laboratory diagnosis of FFI have been retrospectively reviewed. The clinical features and the results of the complementary tests, including polysomnography (PSG), brain imaging and genetic analysis, were used. Two male and three female patients were recruited in this study. Three of the five patients had more comprehensive family medical records...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28612377/apolipoprotein-e-genotype-impact-on-memory-and-attention-in-older-persons-the-moderating-role-of-personality-phenotype
#20
Benjamin P Chapman, Ralph H B Benedict, Feng Lin, Shumita Roy, Antoine Porteinsson, Kinga Szigeti, Howard Federoff, Mark Mapstone
OBJECTIVES: To determine if phenotypic personality traits modify the association of Apolipoprotein E (APOE) genotypes with different domains of cognitive function. DESIGN: Cross-sectional. METHODS: 172 non-demented older adults were administered the NEO-Five Factor Inventory (NEO-FFI), a battery of neuropsychological tests assessing memory, attention, executive function, language, and visuospatial ability, and underwent APOE genotyping. Multivariate (multiple-dependent variable) regression models predicting cognitive domains tested APOE interactions with personality traits, adjusting for age, sex, and education...
June 14, 2017: International Journal of Geriatric Psychiatry
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