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https://www.readbyqxmd.com/read/29718878/fatal-familial-insomnia-presenting-with-agrypnia-excitata-and-very-low-atonia-index-level-a-case-report-and-literature-review
#1
Tae-Won Yang, Byeongsu Park, Keun Tae Kim, Jin-Sun Jun, Young-Soo Kim, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee, Ki-Young Jung
RATIONALE: Fatal familial insomnia (FFI) is a human prion disease that is characterized by sleep-wake cycle deterioration, loss of slow-wave sleep, and motor overactivation over the daily 24-hour period. PATIENT CONCERNS: Here, we report the case of a 57-year-old man who had an irregular sleep-wake cycle and exhibited frequent movements and vocalizations during sleep. DIAGNOSES: Video-polysomnography showed disrupted sleep structure, rapid alternation between sleep stages, and an absence of sleep spindles and slow-wave sleep...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29701889/emergency-department-adult-fiberoptic-intubations-incidence-indications-and-implications-for-training
#2
Emily M Hayden, Daniel J Pallin, Susan R Wilcox, James A Gordon, Jestin N Carlson, Ron M Walls, Calvin A Brown
BACKGROUND: To describe the frequency, indications and outcomes of flexible fiberoptic intubations (FFI) performed in the emergency department (ED). METHODS: From the National Emergency Airway Registry (NEAR), we identified all encounters during 7/1/02 through 12/31/12 with the use of FFI. We determined patient, provider and intubation characteristics, success and failure rates, and modes of intubation rescue. RESULTS: Among 17,910 intubations of patients >15 years old at 13 EDs, FFI was used in 204 cases (1...
April 27, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29682233/personality-factors-and-cognitive-functioning-in-elderly-with-parkinson-s-disease
#3
Neusa Maria de Oliveira Chardosim, Camila Rosa Oliveira, Manuela Polidoro Lima, Marianne Farina, Valéria Gonzatti, Dalton Breno Costa, Aline Sória Pereira, Luis Henrique Paloski, Tatiana Quarti Irigaray, Irani Iracema de Lima Argimon
Parkinson's disease (PD) is a chronic and progressive neurological disease, resulting from cell degeneration in the substantia nigra, responsible for the production of dopamine. Objective: This study aimed to characterize the cognitive functioning, personality factors and prevalence of depressive and anxiety symptoms in individuals with Parkinson's disease (PD). Furthermore, this study sought to analyze whether personality factors were predictors of cognitive functioning. Methods: The sample consisted of 30 elderly with PD...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29676187/decrease-of-ryr2-in-the-prion-infected-cell-line-and-in-the-brains-of-the-scrapie-infected-mice-models-and-the-patients-of-human-prion-diseases
#4
Qi Shi, Jian-Le Li, Yue Ma, Li-Ping Gao, Kang Xiao, Jing Wang, Wei Zhou, Cao Chen, Yan-Jun Guo, Xiao-Ping Dong
The levels of ryanodine receptors (RyRs) are usually increased in the brains of human Alzheimer disease (AD) and AD animal models. To evaluate the underlying alteration of brain RyRs in prion disease, scrapie infected cell line SMB-S15 and its infected mice were tested. RyR2 specific Western blots revealed markedly decreased RyR2 levels both in the cells and in the brains of infected mice. Assays of the brain samples of other scrapie (agents 139A and ME7) infected mice collected at different time-points during incubation period showed time-dependent decreases of RyR2...
April 20, 2018: Prion
https://www.readbyqxmd.com/read/29664551/socio-demographic-and-psychological-determinants-of-exclusive-breastfeeding-after-six-months-postpartum-a-polish-case-cohort-study
#5
Karolina Maria Maliszewska, Mariola Bidzan, Małgorzata Świątkowska-Freund, Krzysztof Preis
OBJECTIVES: The purpose of this study was to explore the socio-demographic and psychological factors connected with exclusive breastfeeding after 6 months postpartum. MATERIAL AND METHODS: A total of 251 women filled in questionnaires in the first week postpartum, then again after 3 and 6 months. The questionnaires included socio-demographic and medical questions, as well as psychological tools: the NEO-FFI Personality Inventory, the Berlin Social Support Scales (BSSS), and the Edinburgh Postnatal Depression Scale (EPDS)...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29642625/analysis-of-sociodemographic-psychological-and-genetic-factors-contributing-to-depressive-symptoms-in-pre-peri-and-postmenopausal-women
#6
Elżbieta Grochans, Małgorzata Szkup, Artur Kotwas, Jacek Kopeć, Beata Karakiewicz, Anna Jurczak
Depressive symptoms that are faced by women in the pre-, peri-, and postmenopausal periods are determined by a wide array of sociodemographic, psychological, and biological variables. The aim of our study was to identify factors that contribute to depressive problems at this stage of life. The study included 815 healthy Polish women aged 45-60 years. The survey part was conducted using the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory (STAI), the Neuroticism-Extroversion-Openness Five Factor Inventory (NEO-FFI), and a self-developed questionnaire...
April 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29626046/using-the-oxford-foot-model-to-determine-the-association-between-objective-measures-of-foot-function-and-results-of-the-aofas-ankle-hindfoot-scale-and-the-foot-function-index-a-prospective-gait-analysis-study-in-germany
#7
Tanja Kostuj, Felix Stief, Kirsten Anna Hartmann, Katharina Schaper, Mohammad Arabmotlagh, Mike H Baums, Andrea Meurer, Frank Krummenauer, Sebastian Lieske
OBJECTIVE: After cross-cultural adaption for the German translation of the Ankle-Hindfoot Scale of the American Orthopaedic Foot and Ankle Society (AOFAS-AHS) and agreement analysis with the Foot Function Index (FFI-D), the following gait analysis study using the Oxford Foot Model (OFM) was carried out to show which of the two scores better correlates with objective gait dysfunction. DESIGN AND PARTICIPANTS: Results of the AOFAS-AHS and FFI-D, as well as data from three-dimensional gait analysis were collected from 20 patients with mild to severe ankle and hindfoot pathologies...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625867/balloon-aortic-valvuloplasty-for-congenital-aortic-stenosis-a-14-year-single-centre-review
#8
Benjamin Auld, Lindsay Carrigan, Cameron Ward, Robert Justo, Nelson Alphonso, Ben Anderson
BACKGROUND: The approach to intervention for congenital aortic valve stenosis (AS) differs depending upon centre bias toward a primary catheter or surgical approach. We therefore investigated associations with freedom from re-intervention (FFI) in the cohort of children who underwent primary balloon aortic valvuloplasty (BAV) for congenital AS in our centre. METHODS: All patients who underwent BAV as a primary procedure in the period between 2001 and 2015 in a single service were included...
March 1, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29623465/does-medical-students-personality-have-an-impact-on-their-intention-to-show-empathic-behavior
#9
Tamara Seitz, Angelika S Längle, Charles Seidman, Henriette Löffler-Stastka
Several studies have demonstrated a correlation between specific personal traits and empathy. However, it is not clear if persons with certain personality traits lack the intent to show empathic behavior or if other factors independent of their intent are affecting their empathic behavior. To answer this question, we asked 132 medical students to fill out questionnaires evaluating the General Intention to Show Empathic Behavior (GISEB) and the five personality traits measured by NEO Five-Factor Inventory (NEO-FFI)...
April 6, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29587725/associations-between-emotional-intelligence-empathy-and-personality-in-japanese-medical-students
#10
Keiko Abe, Masayuki Niwa, Kazuhiko Fujisaki, Yasuyuki Suzuki
BACKGROUND: It is known that empathic communication is important for physicians to achieve higher patient satisfaction and health outcomes. Emotional intelligence (EI), empathy and personality in medical students predict students' individual disposition and their emotional and empathic perceptions. This study aimed to investigate: 1) The association between empathy, EI and personality, and 2) Gender differences in the association between empathy, EI and personality. METHOD: Participants were 357 1st year medical students from 2008 to 2011 at one medical school in Japan...
March 27, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29569252/the-clinical-features-in-chinese-patients-with-prnp-d178n-mutation
#11
S Chen, S He, X-H Shi, X-J Shen, K-K Liang, J-H Zhao, B-C Yan, J-W Zhang
BACKGROUND AND PURPOSE: Fatal familial insomnia (FFI) is an autosomal dominant disease due to the D178N mutation of PRNP gene coupling with homozygous methionine (Met) at codon 129. It is generally considered that D178N mutation cases with 129 M/M homozygotes present as FFI, and 129 V/V as genetic CJD. However, the frequency of 129 Met alleles in Chinese population is much higher than that in Caucasians. This study aims to investigate the clinical features and genetic characteristics of Chinese D178N mutants in this genetic context...
March 22, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29522786/pavlovian-to-instrumental-transfer-a-new-paradigm-to-assess-pathological-mechanisms-with-regard-to-the-use-of-internet-applications
#12
Verena Vogel, Ines Kollei, Theodora Duka, Jan Snagowski, Matthias Brand, Astrid Müller, Sabine Loeber
At present, there is a considerable lack of human studies that investigated the impact of conditioned cues on instrumental responding although these processes are considered as core mechanisms contributing to the development and maintenance of addictive behaviours. No studies are available that assessed these processes with regard to Internet gaming or Internet shopping applications. We thus developed a Pavlovian-to-instrumental transfer (PIT)-Paradigm implementing appetitive stimuli related to Internet gaming and Internet shopping applications and investigated whether an outcome-specific PIT-Effect is observed...
March 6, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29498147/subtypes-of-depression-and-their-overlap-in-a-naturalistic-inpatient-sample-of-major-depressive-disorder
#13
Richard Musil, Florian Seemüller, Sebastian Meyer, Ilja Spellmann, Mazda Adli, Michael Bauer, Klaus-Thomas Kronmüller, Peter Brieger, Gerd Laux, Wolfram Bender, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Rebecca Schennach, Hans-Jürgen Möller, Michael Riedel
Subtyping depression is important in order to further delineate biological causes of depressive syndromes. The aim of this study was to evaluate clinical and outcome characteristics of distinct subtypes of depression and to assess proportion and features of patients fulfilling criteria for more than one subtype. Melancholic, atypical and anxious subtypes of depression were assessed in a naturalistic sample of 833 inpatients using DSM-IV specifiers based on operationalized criteria. Baseline characteristics and outcome criteria at discharge were compared between distinct subtypes and their overlap...
March 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29493478/deep-brain-stimulation-of-the-supero-lateral-branch-of-the-medial-forebrain-bundle-does-not-lead-to-changes-in-personality-in-patients-suffering-from-severe-depression
#14
Bettina H Bewernick, Hannah M Kilian, Klaudius Schmidt, Ruth E Reinfeldt, Sarah Kayser, Volker A Coenen, Sebastian Markett, Thomas E Schlaepfer
BACKGROUND: Reports of changes in patients' social behavior during deep brain stimulation (DBS) raised the question whether DBS induces changes in personality. This study explored if (1) DBS is associated with changes in personality in patients suffering from treatment-resistant depression (TRD), (2) how personality dimensions and depression are associated, and (3) if TRD patients' self-ratings of personality are valid. METHODS: TRD patients were assessed before DBS (n = 30), 6 months (t2, n = 21), 2 (t3, n = 17) and 5 years (t4, n = 11) after the initiation of DBS of the supero-lateral branch of the medial forebrain bundle (slMFB-DBS)...
March 1, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29479128/association-of-personality-profiles-with-depressive-anxiety-and-cancer-related-symptoms-in-patients-undergoing-chemotherapy
#15
Stefana Morgan, Bruce Cooper, Steven Paul, Marilyn J Hammer, Yvette P Conley, Jon D Levine, Christine Miaskowski, Laura B Dunn
Background: This study identified latent classes of cancer patients based on Big Five personality dimensions and evaluated for differences in demographic and clinical characteristics, depression, anxiety, and cancer-related symptoms. Methods: Patients (n=1248) with breast, gastrointestinal, gynecological, or lung cancer completed the Center for Epidemiological Studies-Depression scale, Spielberger State-Trait Anxiety Inventories, NEO-Five Factor Inventory (NEO-FFI), and Memorial Symptom Assessment Scale (MSAS)...
October 15, 2017: Personality and Individual Differences
https://www.readbyqxmd.com/read/29451991/exogenous-ketone-salts-do-not-improve-cognitive-responses-after-a-high-intensity-exercise-protocol-in-healthy-college-aged-males
#16
Hunter S Waldman, Steven A Basham, Ffi G Price, JohnEric W Smith, Harish Chander, Adam C Knight, Ben M Krings, Matthew J McAllister
This study examined the effects of a D-ß-hydroxybutyrate (ßHB) containing beverage on cognitive and performance measures during a bout of repeated Wingates. Fifteen healthy, college-aged males (mean ± SD age: 23.1 ± 2.4 years, height: 165.4 ± 2.0 cm, mass: 81.4 ± 9.2 kg) volunteered for the present study. Trial 1 consisted of baseline measures and familiarization for the protocol. During trials 2 and 3, subjects reported to the laboratory, after a 10 h fast, and ingested 11.38 grams of ßHB or a placebo (PLA) beverage 30 min before exercise...
February 16, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29437061/mid-term-follow-up-of-patients-with-hindfoot-arthrodesis-with-retrograde-compression-intramedullary-nail-in-charcot-neuroarthropathy-of-the-hindfoot
#17
M Chraim, S Krenn, H M Alrabai, H-J Trnka, P Bock
AIMS: Hindfoot arthrodesis with retrograde intramedullary nailing has been described as a surgical strategy to reconstruct deformities of the ankle and hindfoot in patients with Charcot arthropathy. This study presents case series of Charcot arthropathy patients treated with two different retrograde intramedullary straight compression nails in order to reconstruct the hindfoot and assess the results over a mid-term follow-up. PATIENTS AND METHODS: We performed a retrospective analysis of 18 consecutive patients and 19 operated feet with Charcot arthropathy who underwent a hindfoot arthrodesis using a retrograde intramedullary compression nail...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29409268/clinical-and-radiographic-outcomes-of-the-kramer-osteotomy-in-the-treatment-of-bunionette-deformity
#18
David C Lee, Cesar de Cesar Netto, Jackson Rucker Staggers, Rebecca Siegel, Richard Chen, Su-Young Bae, Lew C Schon
BACKGROUND: Bunionette deformity is a painful bony prominence of the 5th metatarsal. We evaluated outcomes of using a Kramer osteotomy to treat this condition. METHODS: Retrospective study of patients treated with a Kramer osteotomy from 2003 and 2016. Outcome measures included Foot Functional Index (FFI) and radiographic measurements. RESULTS: 38 patients (43 feet) with an average follow-up of 55 months. Mean postoperative FFI1 was 19.4...
July 18, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29409260/resection-or-preservation-of-the-metatarsal-heads-in-rheumatoid-forefoot-surgery-a-randomised-clinical-trial
#19
Joost C Schrier, Noel L Keijsers, Giovanni A Matricali, Cees C P M Verheyen, Jan Willem K Louwerens
BACKGROUND: Despite impressive results of the pharmacological management of rheumatoid arthritis, still certain patients suffer from rheumatoid forefoot problems. Surgical treatment of these forefoot deformities can be an option. In literature no high-quality studies on this topic can be found. The goal of present study is to compare the results of a metatarsal head (MTH) resecting technique with a MTH preserving technique in the operative treatment of severe rheumatoid forefoot deformity...
August 10, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29409251/large-variation-in-use-of-patient-reported-outcome-measures-a-survey-of-188-foot-and-ankle-surgeons
#20
R Zwiers, H Weel, W H Mallee, G M M J Kerkhoffs, C N van Dijk
BACKGROUND: There is an increasing interest in the use of patient reported outcome measures (PROMs). However, there is a large variety of PROMs and a lack of consensus regarding preference for their use. Aim of this study is to determine how often PROMS are used for foot and ankle disorders, for what purpose PROMs are used, and what the preferences of the foot and ankle surgeons are, when choosing a PROM to use. METHODS: Members of the Ankleplatform Study Group-Science of Variation Collaborative were invited to participate in this survey by email...
March 9, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
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