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Early Childhood Development

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https://www.readbyqxmd.com/read/28335020/znhit3-is-defective-in-peho-syndrome-a-severe-encephalopathy-with-cerebellar-granule-neuron-loss
#1
Anna-Kaisa Anttonen, Anni Laari, Maria Kousi, Yawei J Yang, Tiina Jääskeläinen, Mirja Somer, Eija Siintola, Eveliina Jakkula, Mikko Muona, Saara Tegelberg, Tuula Lönnqvist, Helena Pihko, Leena Valanne, Anders Paetau, Melody P Lun, Johanna Hästbacka, Outi Kopra, Tarja Joensuu, Nicholas Katsanis, Maria K Lehtinen, Jorma J Palvimo, Anna-Elina Lehesjoki
Progressive encephalopathy with oedema, hypsarrhythmia, and optic atrophy (PEHO) syndrome is an early childhood onset, severe autosomal recessive encephalopathy characterized by extreme cerebellar atrophy due to almost total granule neuron loss. By combining homozygosity mapping in Finnish families with Sanger sequencing of positional candidate genes and with exome sequencing a homozygous missense substitution of leucine for serine at codon 31 in ZNHIT3 was identified as the primary cause of PEHO syndrome. ZNHIT3 encodes a nuclear zinc finger protein previously implicated in transcriptional regulation and in small nucleolar ribonucleoprotein particle assembly and thus possibly to pre-ribosomal RNA processing...
March 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28333529/the-long-arm-of-childhood-preschool-associations-with-adolescent-health
#2
Terri J Sabol, Lindsay Till Hoyt
The current study examines the extent to which participation in preschool at age 4 is associated with blood pressure, body mass index, and awakening cortisol at age 15. We capitalize on data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development to examine differences in adolescent health among children who attended preschool, parental care, or home-based care at age 4 (n = 742). Using quasi-experimental methods, we found that preschool participation was associated with multiple positive health outcomes in adolescence...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28328688/prioritizing-the-care-of-critically-ill-children-in-south-africa-how-does-screen-perform-against-other-triage-tools
#3
Bhakti Hansoti, Peter Hodkinson, Lee Wallis
OBJECTIVE: Childhood mortality remains unacceptably high. In low-resource settings, children with critical illness often present for care. Current triage strategies are time consuming and require trained health care workers. To address this limitation, our team developed a simple subjective tool, SCREEN (Sick Children Require Emergency Evaluation Now), which is easy to administer, to identify critically ill children. This article presents the development of the SCREEN program and evaluates its performance when compared with other commonly implemented triage tools in low-resource settings...
March 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28327104/characterizing-early-child-growth-patterns-of-height-for-age-in-an-urban-slum-cohort-of-bangladesh-with-functional-principal-component-analysis
#4
Yin Zhang, Jianhui Zhou, Feiyang Niu, Jeffrey R Donowitz, Rashidul Haque, William A Petri, Jennie Z Ma
BACKGROUND: Early childhood is a critical stage of physical and cognitive growth that forms the foundation of future wellbeing. Stunted growth is presented in one of every 4 children worldwide and contributes to developmental impairment and under-five mortality. Better understanding of early growth patterns should allow for early detection and intervention in malnutrition. We aimed to characterize early child growth patterns and quantify the change of growth curves from the World Health Organization (WHO) Child Growth Standards...
March 21, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28326533/dysregulated-fear-social-inhibition-and-respiratory-sinus-arrhythmia-a%C3%A2-replication-and-extension
#5
Kristin A Buss, Elizabeth L Davis, Nilam Ram, Michael Coccia
Behavioral inhibition indicates increased risk for development of social anxiety. Recent work has identified a pattern of dysregulated fear (DF), characterized by high fear in low-threat situations, that provides a more precise marker of developmental risk through early childhood. This study tested a new longitudinal sample of children (n = 124) from ages 24 to 48 months. Replicating prior findings, at 24 months, we identified a pattern of fearful behavior across contexts marked by higher fear to putatively low-threat situations...
March 21, 2017: Child Development
https://www.readbyqxmd.com/read/28324701/stress-reactivity-and-its-effects-on-subsequent-food-intake-in-depressed-and-healthy-women-with-and-without-adverse-childhood-experiences
#6
Katja Wingenfeld, Linn K Kuehl, Anita Boeker, Katharina Schultebraucks, Kristin Ritter, Julian Hellmann-Regen, Christian Otte, Carsten Spitzer
BACKGROUND: Adverse childhood experiences (ACE) increase the risk to develop major depressive disorder (MDD) and obesity or metabolic syndrome in adulthood. In addition, ACE may be associated with an exaggerated endocrine response to stress, which, in turn, may lead to enhanced food intake resulting in obesity and metabolic problems. METHODS: We systematically examined the stress response and consecutive food intake in 32 women with MDD and ACE as determined by a clinical interview (Early Trauma Inventory), 52 women with MDD without ACE, 22 women with ACE but no current or lifetime MDD and 37 healthy women without either MDD or ACE...
March 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28322222/white-matter-maturation-is-associated-with-the-emergence-of-theory-of-mind-in-early-childhood
#7
Charlotte Grosse Wiesmann, Jan Schreiber, Tania Singer, Nikolaus Steinbeis, Angela D Friederici
The ability to attribute mental states to other individuals is crucial for human cognition. A milestone of this ability is reached around the age of 4, when children start understanding that others can have false beliefs about the world. The neural basis supporting this critical step is currently unknown. Here, we relate this behavioural change to the maturation of white matter structure in 3- and 4-year-old children. Tract-based spatial statistics and probabilistic tractography show that the developmental breakthrough in false belief understanding is associated with age-related changes in local white matter structure in temporoparietal regions, the precuneus and medial prefrontal cortex, and with increased dorsal white matter connectivity between temporoparietal and inferior frontal regions...
March 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28320408/factors-of-physical-activity-among-chinese-children-and-adolescents-a-systematic-review
#8
REVIEW
Congchao Lu, Ronald P Stolk, Pieter J J Sauer, Anna Sijtsma, Rikstje Wiersma, Guowei Huang, Eva Corpeleijn
BACKGROUND: Lack of physical activity is a growing problem in China, due to the fast economic development and changing living environment over the past two decades. The aim of this review is to summarize the factors related to physical activity in Chinese children and adolescents during this distinct period of development. METHODS: A systematic search was finished on Jan 10(th), 2017, and identified 2200 hits through PubMed and Web of Science. English-language published studies were included if they reported statistical associations between factors and physical activity...
March 21, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28319949/the-impact-of-kidney-development-on-the-life-course-a-consensus-document-for-action
#9
(no author information available yet)
Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future...
March 21, 2017: Nephron
https://www.readbyqxmd.com/read/28318659/cardiovascular-and-general-health-status-of-adults-with-trisomy-21
#10
Samuel A Hayes, Shelby Kutty, Joshua Thomas, Joyce T Johnson, Anji T Yetman
BACKGROUND: Patients with Trisomy 21 are now living well into adulthood. Little data exists to assist the cardiologist in the care of these patients. We sought to examine the cardiac and general health status of adults with Trisomy 21 undergoing cardiac evaluation. METHODS & RESULTS: A retrospective review of all affected adults >21years followed at 2 tertiary care institutions was performed. Of 193 patients identified, median age was 31 (range 21.1-60.5) years...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28318371/p-selectin-endocan-and-some-adhesion-molecules-in-obese-children-and-adolescents-with-non-alcoholic-fatty-liver-disease
#11
Ala Ustyol, Esra Aycan Ustyol, Figen Gurdol, Funda Kokali, Seldag Bekpınar
There is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan and adhesion molecules such as P-selectin derived from the endothelium and platelets in obese children and adolescents with NAFLD. One hundred obese patients and 40 lean controls were enrolled. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver. Blood samples were assayed for endocan, P-selectin, platelet-derived growth factor (PDGF), intercellular cell adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28318338/latent-class-profiles-of-anxiety-symptom-trajectories-from-preschool-through-school-age
#12
Sarah J Kertz, Chad Sylvester, Rebecca Tillman, Joan L Luby
Anxiety typically arises early in childhood and decreases during school age. However, little is known about the earlier developmental course of anxiety in preschool, especially in at risk children, posing a clinically important problem. Given that anxiety in youth has a chronic course for some and also predicts later development of other mental health problems, it is important to identify factors early in development that may predict chronic anxiety symptoms. At-risk children (oversampled for depression) and caregivers completed 6 assessment waves beginning at preschool age (between 3-5...
March 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28317113/temperamental-markers-in-toddlers-with-autism-spectrum-disorder
#13
Suzanne L Macari, Judah Koller, Daniel J Campbell, Katarzyna Chawarska
BACKGROUND: Although temperament has been recognized as an important contributor to childhood psychopathology, its role in emergent autism spectrum phenotypes is not well understood. This study examined whether toddlers with autism spectrum disorder (ASD) display temperamental vulnerabilities compared to toddlers with other developmental challenges, whether these characteristics are distinct from core autism symptoms, if they are stable over time, and if they contribute to social outcomes in preschool...
March 20, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28316769/etiological-influences-on-the-stability-of-autistic-traits-from-childhood-to-early-adulthood-evidence-from-a-twin-study
#14
Mark J Taylor, Christopher Gillberg, Paul Lichtenstein, Sebastian Lundström
BACKGROUND: Autism spectrum disorders (ASD) are persistent and lifelong conditions. Despite this, almost all twin studies focus on childhood. This twin study investigated the stability of autistic traits from childhood to early adulthood and explored the degree to which any stability could be explained by genetic or environmental factors. METHODS: Parents of over 2500 twin pairs completed questionnaires assessing autistic traits when twins were aged either 9 or 12 years and again when twins were aged 18...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28315895/healthy-growth-and-development
#15
Ken K Ong
Observational and experimental studies indicate a remarkably consistent association between rapid growth and weight gain during infancy and higher risks for obesity in later childhood and adult life. This association appears to be equally relevant to breastfed and formula milk-fed infants, and infants small for gestational age and with normal birth weight. The type of infant milk feeding, energy intake, and milk nutrient composition are important determinants of infant growth and weight gain. There is also accumulating evidence that genetic factors related to adult obesity susceptibility act in the central nervous system to regulate intrinsic levels of infant appetite and satiety, and they impact on infant dietary behaviors to influence growth and weight gain...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28315889/patterns-of-growth-in-early-childhood-and-infectious-disease-and-nutritional-determinants
#16
Robert E Black
The physical growth of young children in low- and middle-income countries is reduced compared to international standards. The deviations in growth in both weight and height are greatest in the first 2 years of life and this has serious consequences for child mortality, development, adult stature, and health. The determinants of these patterns of growth faltering include intergenerational factors, such as maternal height, short birth interval, and conditions in pregnancy, including maternal underweight and anemia...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28315509/evaluation-of-late-cerebral-vascular-complications-in-cranially-irradiated-pediatric-cancer-patients-with-magnetic-resonance-angiography
#17
Serhan Kupeli, Kenan Bicakci, Gulay Sezgin, Ibrahim Bayram
BACKGROUND: We aimed to establish the early diagnosis of cerebral vascular complications by using cerebral magnetic resonance angiography (MRA) in patients who were treated with cranial RT in childhood as part of their cancer treatment. PROCEDURE: Patients who had received cranial RT before the age of 18 and had been in remission for at least 1 year were enrolled in the study. A data form including demographic and clinical characteristics and findings of cerebral MRA was filled in for each patient...
March 18, 2017: Tumori
https://www.readbyqxmd.com/read/28315125/evidence-of-non-linear-associations-between-frustration-related-prefrontal-cortex-activation-and-the-normal-abnormal-spectrum-of-irritability-in-young-children
#18
Adam S Grabell, Yanwei Li, Jeff W Barker, Lauren S Wakschlag, Theodore J Huppert, Susan B Perlman
Burgeoning interest in early childhood irritability has recently turned toward neuroimaging techniques to better understand normal versus abnormal irritability using dimensional methods. Current accounts largely assume a linear relationship between poor frustration management, an expression of irritability, and its underlying neural circuitry. However, the relationship between these constructs may not be linear (i.e., operate differently at varying points across the irritability spectrum), with implications for how early atypical irritability is identified and treated...
March 18, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28314946/late-onset-islet-autoimmunity-in-childhood-the-diabetes-autoimmunity-study-in-the-young-daisy
#19
Brigitte I Frohnert, Lisa Ide, Fran Dong, Anna E Barón, Andrea K Steck, Jill M Norris, Marian J Rewers
AIMS/HYPOTHESIS: We sought to assess the frequency, determinants and prognosis for future diabetes in individuals with islet autoimmunity and whether these factors differ depending on the age of onset of islet autoimmunity. METHODS: A prospective cohort (n = 2547) of children from the general population who had a high-risk HLA genotype and children who had a first-degree relative with type 1 diabetes were followed for up to 21 years. Those with the persistent presence of one or more islet autoantibodies were categorised as early-onset (<8 years of age, n = 143, median 3...
March 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28314682/hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-an-update-and-review
#20
REVIEW
Viral M Patel, Marc Z Handler, Robert A Schwartz, W Clark Lambert
Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is a rare genetic disorder that predisposes individuals to multiple cutaneous leiomyomas, renal cell carcinomas, and in women, uterine leiomyomas. Also known as Reed syndrome, it is caused by a germline heterozygous mutation of the fumarate hydratase tumor suppressor gene. HLRCC is associated with significant morbidity because of pain from cutaneous and uterine leiomyomas, the cutaneous pain often of unique character. Although genetic testing is currently considered the criterion standard to diagnose HLRCC, newer immunohistochemistry markers may provide rapid and cost effective alternatives to genetic testing...
March 14, 2017: Journal of the American Academy of Dermatology
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