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https://www.readbyqxmd.com/read/28816105/thiazolidinedione-drugs-in-the-treatment-of-type-2-diabetes-mellitus-past-present-and-future
#1
Melissa A Davidson, Donald R Mattison, Laurent Azoulay, Daniel Krewski
Thiazolidinedione (TZD) drugs used in the treatment of type 2 diabetes mellitus (T2DM) have proven effective in improving insulin sensitivity, hyperglycemia, and lipid metabolism. Though well tolerated by some patients, their mechanism of action as ligands of peroxisome proliferator-activated receptors (PPARs) results in the activation of several pathways in addition to those responsible for glycemic control and lipid homeostasis. These pathways, which include those related to inflammation, bone formation, and cell proliferation, may lead to adverse health outcomes...
August 17, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28807464/sex-estimation-using-dimensions-around-the-nutrient-foramen-of-the-long-bones-of-the-arm-and-forearm-in-south-africans
#2
Palesa Mokoena, Brendon K Billings, Mubarak A Bidmos, Pedzisai Mazengenya
South Africa has had an increase in rates of crime, interpersonal violence and homicide since the introduction of democracy in 1994. Forensic osteological standards was lacking for South Africans of different population groups necessitating the generation of new standards for forensic identification of individuals from skeletal remains. For these reasons, there is a concerted demand for methods of identifying skeletal remains with sex being amongst the most important of the biological characteristics required...
July 10, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28803756/speciation-range-contraction-and-extinction-in-the-endemic-new-zealand-king-shag-complex
#3
Nicolas J Rawlence, Charlotte E Till, Luke J Easton, Hamish G Spencer, Rob Schuckard, David S Melville, R Paul Scofield, Alan J D Tennyson, Matt J Rayner, Jonathan M Waters, Martyn Kennedy
New Zealand's endemic King Shag (Leucocarbo carunculatus) has occupied only a narrow portion of the northeastern South Island for at least the past 240years. However, pre-human Holocene fossil and archaeological remains have suggested a far more widespread distribution of the three Leucocarbo species (King, Otago, Foveaux) on mainland New Zealand at the time of Polynesian settlement in the late 13th Century CE. We use modern and ancient DNA, and morphometric and osteological analyses, of modern King Shags and Holocene fossil Leucocarbo remains to assess the pre-human distribution and taxonomic status of the King Shag on mainland New Zealand, and the resultant conservation implications...
August 10, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28801843/sex-estimation-of-infants-through-geometric-morphometric-analysis-of-the-ilium
#4
Enrique J Estévez, Sandra López-Lázaro, Claudia López-Morago, Inmaculada Alemán, Miguel C Botella
In archeology or forensics, the analysis of the ilia is often used to determine the age and sex of unknown individuals. However, sex determination using the skeletal remains of individuals who did not develop secondary sexual characteristics remains controversial. Accurately estimating the sex of subadults is hampered by a small number of studies based on identified skeletal collections of juvenile individuals. Here, we analyzed the sexual dimorphism of the subadult ilia using geometric morphometric techniques and individuals from the osteological collection of identified subadults from San José's graveyard (Granada)...
August 11, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28799880/a-morphometric-survey-of-the-parasellar-region-in-more-than-2700-skulls-emphasis-on-the-middle-clinoid-process-variants-and-implications-in-endoscopic-and-microsurgical-approaches
#5
Akshay Sharma, Gabrielle E Rieth, Joseph E Tanenbaum, James S Williams, Nakao Ota, Srikant Chakravarthi, Sunil Manjila, Amin Kassam, Bulent Yapicilar
OBJECTIVE The middle clinoid process (MCP) is a bony projection that extends from the sphenoid bone near the lateral margin of the sella turcica. The varied prevalence and morphological features of the MCP in populations stratified by age, race, and sex are unknown; however, the knowledge of its anatomy and preoperative recognition on CT scans can aid greatly in complication avoidance and management. The aim of this study was to further illustrate the surgical anatomy of the parasellar region and to quantify the incidence of MCP and caroticoclinoid rings (CCRs) in dried preserved human anatomical specimens...
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28776674/skeletal-ontogeny-of-the-vertebral-column-and-of-the-fins-in-shi-drum-umbrina-cirrosa-teleostei-perciformes-sciaenidae-a-new-candidate-species-for-aquaculture
#6
M Neofytou, D G Sfakianakis, G Koumoundouros, C C Mylonas, M Kentouri
The osteological development of the vertebral column and fins in shi drum Umbrina cirrosa was studied in order to improve knowledge for its introduction in Mediterranean aquaculture. The osteological development was studied in 171 individuals, of total length (LT ) from 2·7 to 30·2 mm that were reared under the mesocosm technique. Vertebral ontogeny starts at 3·4 and 4·0 mm LT , with the formation of the first cartilaginous neural and haemal arches, and spines, respectively, and is completed with the full attainment of epicentrals (12·5 mm LT )...
August 3, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28776670/archosauriform-endocranial-morphology-and-osteological-evidence-for-semiaquatic-sensory-adaptations-in-phytosaurs
#7
Emily J Lessner, Michelle R Stocker
The examination of endocranial data of archosauriforms has led to advances on the evolution of body size, nerve pathways, and sensory abilities. However, much of that research has focused on bird-line archosaurs, resulting in a skewed view of Archosauria. Phytosauria, a hypothesized sister taxon to or early-branching member of Archosauria, provides a potential outgroup condition. Most previous phytosaur endocranial studies were executed without the use of modern technology and focused on derived members of Phytosauria...
August 4, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28762500/myology-of-the-forelimb-of-majungasaurus-crenatissimus-theropoda-abelisauridae-and-the-morphological-consequences-of-extreme-limb-reduction
#8
Sara H Burch
Forelimb reduction occurred independently in multiple lineages of theropod dinosaurs. Although tyrannosaurs are renowned for their tiny, two-fingered forelimbs, the degree of their reduction in length is surpassed by abelisaurids, which possess an unusual morphology distinct from that of other theropods. The forelimbs of abelisaurids are short but robust and exhibit numerous crests, tubercles, and scars that allow for inferences of muscle attachment sites. Phylogenetically based reconstructions of the musculature were used in combination with close examination of the osteology in the Malagasy abelisaurid Majungasaurus to create detailed muscle maps of the forelimbs, and patterns of the muscular and bony morphology were compared with those of extant tetrapods with reduced or vestigial limbs...
August 1, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28747987/experimental-determination-of-three-dimensional-cervical-joint-mobility-in-the-avian-neck
#9
Robert E Kambic, Andrew A Biewener, Stephanie E Pierce
BACKGROUND: Birds have highly mobile necks, but neither the details of how they realize complex poses nor the evolution of this complex musculoskeletal system is well-understood. Most previous work on avian neck function has focused on dorsoventral flexion, with few studies quantifying lateroflexion or axial rotation. Such data are critical for understanding joint function, as musculoskeletal movements incorporate motion around multiple degrees of freedom simultaneously. Here we use biplanar X-rays on wild turkeys to quantify three-dimensional cervical joint range of motion in an avian neck to determine patterns of mobility along the cranial-caudal axis...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28747476/ancient-dna-and-morphometric-analysis-reveal-extinction-and-replacement-of-new-zealand-s-unique-black-swans
#10
Nicolas J Rawlence, Afroditi Kardamaki, Luke J Easton, Alan J D Tennyson, R Paul Scofield, Jonathan M Waters
Prehistoric human impacts on megafaunal populations have dramatically reshaped ecosystems worldwide. However, the effects of human exploitation on smaller species, such as anatids (ducks, geese, and swans) are less clear. In this study we apply ancient DNA and osteological approaches to reassess the history of Australasia's iconic black swans (Cygnus atratus) including the palaeo-behaviour of prehistoric populations. Our study shows that at the time of human colonization, New Zealand housed a genetically, morphologically, and potentially ecologically distinct swan lineage (C...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28740526/evaluation-of-bone-microstructure-in-crps-affected-upper-limbs-by-hr-pqct
#11
Haider Mussawy, Tobias Schmidt, Tim Rolvien, Wolfgang Rüther, Michael Amling
INTRODUCTION: Complex regional pain syndrome (CRPS) is a major complication after trauma, surgery, and/or immobilization of an extremity. The disease often starts with clinical signs of local inflammation and develops into a prolonged phase that is characterized by trophic changes and local osteoporosis and sometimes results in functional impairment of the affected limb. While the pathophysiology of CRPS remains poorly understood, increased local bone resorption plays an undisputed pivotal role...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28736808/comparative-cranial-ontogeny-of-tapirus-mammalia-perissodactyla-tapiridae
#12
S Rocio Moyano, Norberto P Giannini
Skull morphology in tapirs is particularly interesting due to the presence of a proboscis with important trophic, sensory and behavioral functions. Several studies have dealt with tapir skull osteology but chiefly in a comparative framework between fossil and recent species of tapirs. Only one study examined an aspect of cranial ontogeny, development of the sagittal crest (Holbrook. J Zool Soc Lond 2002; 256; 215). Our goal is to describe in detail the morphological changes that occur during the postnatal ontogeny of the skull in two representative tapir species, Tapirus terrestris and Tapirus indicus, and to explore possible functional consequences of their developmental trajectories...
July 24, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28714560/validation-and-reliability-of-the-sex-estimation-of-the-human-os-coxae-using-freely-available-dsp2-software-for-bioarchaeology-and-forensic-anthropology
#13
Jaroslav Brůžek, Frédéric Santos, Bruno Dutailly, Pascal Murail, Eugenia Cunha
OBJECTIVES: A new tool for skeletal sex estimation based on measurements of the human os coxae is presented using skeletons from a metapopulation of identified adult individuals from twelve independent population samples. For reliable sex estimation, a posterior probability greater than 0.95 was considered to be the classification threshold: below this value, estimates are considered indeterminate. By providing free software, we aim to develop an even more disseminated method for sex estimation...
July 17, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28712471/early-pliocene-anuran-fossils-from-kanapoi-kenya-and-the-first-fossil%C3%A2-record-for-the-african-burrowing-frog-hemisus-neobatrachia-hemisotidae
#14
Massimo Delfino
Isolated amphibian bones from the early Pliocene of Kanapoi (West Turkana, Kenya) help to improve the scarce fossil record of the late Neogene and Quaternary amphibians from East Africa. All currently available 579 bones are referable exclusively to the Anura (frogs and toads). More than half of the remains (366) are identified as Hemisus cf. Hemisus marmoratus, an extant species that still inhabits Kenya, but apparently not the northwest of the country and the Turkana area in particular. The rest of the remains are identified simply as Anura indet...
July 13, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28674653/the-comparative-osteology-of-plesiochelys-bigleri-n-sp-a-new-coastal-marine-turtle-from-the-late-jurassic-of-porrentruy-switzerland
#15
Christian Püntener, Jérémy Anquetin, Jean-Paul Billon-Bruyat
BACKGROUND: During the Late Jurassic, several groups of eucryptodiran turtles inhabited the shallow epicontinental seas of Western Europe. Plesiochelyidae are an important part of this first radiation of crown-group turtles into coastal marine ecosystems. Fossils of Plesiochelyidae occur in many European localities, and are especially abundant in the Kimmeridgian layers of the Swiss Jura Mountains (Solothurn and Porrentruy). In the mid-19th century, the quarries of Solothurn (NW Switzerland) already provided a large amount of fossil turtles, most notably Plesiochelys etalloni, the best-known plesiochelyid species...
2017: PeerJ
https://www.readbyqxmd.com/read/28665864/comparison-of-the-faroarm-laser-scanner-with-the-microscribe-digitizer-using-basicranial-measurements
#16
Alexander F Vu, Rao V Chundury, Julian D Perry
PURPOSE: To compare the results of a mechanical 3-dimensional laser scanner for craniofacial measurements of the basicranium to a validated coordinate device. METHODS: Access was granted by the Cleveland Natural History Museum to evaluate the Hamann-Todd Human Osteological Collection for this study. The MicroScribe and the FaroArm were used to gather coordinate data of various bony landmarks measurements including the prosthion, staphylion, hormion, and basion. Seventy-three human skulls were measured and scanned...
June 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28658180/morphometric-analysis-of-the-orbital-process-of-the-palatine-bone-and-its-relationship-to-endoscopic-orbital-apex-surgery
#17
Sarina K Mueller, Suzanne K Freitag, Benjamin S Bleier
BACKGROUND: Endoscopic approaches to the orbit improve the ability to directly access apical lesions while minimizing manipulation of normal structures. Inferomedial orbital access is limited by the orbital process of the palatine bone (OPPB) which prevents dissection and retraction in the inferolateral vector. OBJECTIVE: The objective of this study was to examine the morphometric characteristics of the OPPB and quantify the benefit of complete resection to surgical access...
June 19, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28653414/three-new-species-of-curimatopsis-characiformes-curimatidae-from-the-amazon-basin
#18
B F Melo, C Oliveira
Three new species of Curimatopsis are described from major tributaries of the Amazon basin. Curimatopsis guaporensis n. sp., from the Rio Madeira, belongs to the Curimatopsis evelynae clade and can be distinguished by the distinctive shape of the dark blotch on the caudal peduncle and by the position and shape of the nostrils. Curimatopsis pallida n. sp., from the Rio Negro, also related to C. evelynae, is distinguished from all congeners by the complete absence of pigmentation on the lateral surface of the caudal peduncle...
June 27, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28649466/the-venice-specimen-of-ouranosaurus-nigeriensis-dinosauria-ornithopoda
#19
Filippo Bertozzo, Fabio Marco Dalla Vecchia, Matteo Fabbri
Ouranosaurus nigeriensis is an iconic African dinosaur taxon that has been described on the basis of two nearly complete skeletons from the Lower Cretaceous Gadoufaoua locality of the Ténéré desert in Niger. The entire holotype and a few bones attributed to the paratype formed the basis of the original description by Taquet (1976). A mounted skeleton that appears to correspond to O. nigeriensis has been on public display since 1975, exhibited at the Natural History Museum of Venice. It was never explicitly reported whether the Venice specimen represents a paratype and therefore, the second nearly complete skeleton reported in literature or a third unreported skeleton...
2017: PeerJ
https://www.readbyqxmd.com/read/28613444/interindividual-differences-in-embodied-marginalization-osteological-and-stable-isotope-analyses-of-antebellum-enslaved-individuals
#20
Sophia C Dent
OBJECTIVES: Through pathological and stable isotope analyses, this study probes the stressors, disease ecology, and diets of enslaved individuals from an antebellum plantation cemetery. The study aims to highlight how interindividual isotopic differences reveal that marginalization is not uniformly experienced or embodied. METHODS: The cemetery population consists of 16 individuals; dental and skeletal pathological indicators were collected for all individuals, and light stable isotope ratios (δ(15) N, δ(13) C) were generated from the collagen and hydroxyapatite of nine individuals...
July 8, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
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