keyword
https://read.qxmd.com/read/38404066/dysregulated-cxcl12-expression-in-osteoblasts-promotes-b-lymphocytes-preferentially-homing-to-the-bone-marrow-in-mrl-lpr-mice
#21
JOURNAL ARTICLE
Wenjuan Zheng, Yu Tang, Mengwei Cheng, Cui Ma, Xiaoming Fei, Wei Shi
Objective: Todetect the abnormal distribution of B-lymphocytes between peripheral and bone marrow (BM) compartments and explore the mechanism of abnormal chemotaxis of B-lymphocytes in lupus subjects. Methods: The proportions of CXC chemokine receptor (CXCR)4+ B cells and CFDA-labeled MRL/lpr-derived B cells were detected by flow cytometry. The levels of CXC chemokine ligand (CXCL)12in peripheral blood (PB)were measured by ELISA. The migrated B cells to osteoblasts (OBs) was measured by transwell migration assay...
December 2024: Autoimmunity
https://read.qxmd.com/read/38398338/analysis-of-anakinra-therapy-for-the-deficiency-of-interleukin-1-receptor-antagonist-through-clinical-evidence
#22
REVIEW
Kathryn Pillai, Joshua Pillai, Jun Ling
BACKGROUND: Deficiency of interleukin-1 receptor antagonist (DIRA) is a rare life-threatening autosomal recessive autoinflammatory disease with symptoms including but not limited to osteomyelitis, periostitis, and systemic inflammation. DIRA is developed from the loss-of-function biallelic mutations of the IL1RN gene that encodes IL-1 receptor antagonist (IL-1RA), leading to the unchecked pro-inflammatory signaling and subsequent systemic inflammation. Thus, anakinra as the recombinant IL-1RA has become the primary drug to treat DIRA...
February 10, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397031/three-dimensionally-cultured-jaw-periosteal-cells-attenuate-macrophage-activation-of-cd4-t-cells-and-inhibit-osteoclastogenesis
#23
JOURNAL ARTICLE
Fang He, Liuran Wang, Felix Umrath, Andreas Naros, Siegmar Reinert, Dorothea Alexander
The implementation of a successful therapeutic approach that includes tissue-engineered grafts requires detailed analyses of graft-immune cell interactions in order to predict possible immune reactions after implantation. The phenotypic plasticity of macrophages plays a central role in immune cell chemotaxis, inflammatory regulation and bone regeneration. The present study addresses effects emanating from JPC-seeded β-TCP constructs (3DJPCs) co-cultivated with THP-1 derived M1/M2 macrophages within a horizontal co-culture system...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396834/periosteum-containing-implicit-stem-cells-a-progressive-source-of-inspiration-for-bone-tissue-regeneration
#24
REVIEW
Xinyuan Zhang, Chen Deng, Shengcai Qi
The periosteum is known as the thin connective tissue covering most bone surfaces. Its extrusive bone regeneration capacity was confirmed from the very first century-old studies. Recently, pluripotent stem cells in the periosteum with unique physiological properties were unveiled. Existing in dynamic contexts and regulated by complex molecular networks, periosteal stem cells emerge as having strong capabilities of proliferation and multipotential differentiation. Through continuous exploration of studies, we are now starting to acquire more insight into the great potential of the periosteum in bone formation and repair in situ or ectopically...
February 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396387/chondrosarcoma-of-the-alveolar-process-of-the-mandible-initially-suspected-to-be-a-periodontal-lesion
#25
JOURNAL ARTICLE
Biljana Markovic Vasiljkovic, Aleksa Janovic, Svetlana Antic, Branko Dozic, Milos Bracanovic, Djurdja Bracanovic
Chondrosarcoma (CS) initially suspected to be a periodontal lesion is atypical and rare. To the best of our knowledge, only six similar cases have been reported so far. A 47-year-old woman presented with a discreet swelling of the alveolar process of the mandible, while adjacent mucosa appeared normal. Upon initial intraoral radiography, a periodontal lesion was suspected by the ordinating dentist. Further radiological evaluations included CBCT, CT, and MRI, which showed a thickening of the supporting bone with ground-glass foci but without visible calcifications...
February 6, 2024: Diagnostics
https://read.qxmd.com/read/38387413/craniectomy-with-soft-tissue-reconstruction-for-locally-advanced-non-melanoma-skin-cancer-of-scalp-with-calvarial-invasion-the-nottingham-experience
#26
JOURNAL ARTICLE
Zhen Y Wong, Neil Wickham, Shenbana Bagirathan, Alex Leggate, Stuart J Smith, Jonathan Pollock
INTRODUCTION: Locally advanced non-melanoma skin cancer (NMSC) involving the periosteum or calvarium poses a clinical challenge for patients who are unfit for immunotherapy due to medical comorbidities and/or frailty. This case series aims to investigate outcomes for patients undergoing craniectomy and soft tissue reconstruction. METHOD: Patients who underwent craniectomy and soft tissue reconstruction for invasive NMSC with calvarium or periosteal invasion between 2016 and 2022 were included...
February 6, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38384696/influenza-vaccine-related-periostitis-a-case-report-of-a-rare-complication
#27
Kaitlyn R Julian, Kevin Sweetwood, Daria Motamedi
As social distancing guidelines continue to diminish across the country, viral pathogens that were once absent during the COVID-19 pandemic, such as influenza and RSV, have once again become prominent. Although serious side effects of vaccinations are rare, local complications of bursitis and skin and soft tissue infections are well-documented in the literature. We present a case of 1 such rare side effect: influenza vaccine related periostitis. A 39-year-old male patient presented with left shoulder pain which developed 2 days after an influenza vaccination administered to the left deltoid...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38368556/novel-sheep-model-to-assess-critical-sized-bone-regeneration-with-periosteum-for-in-vivo-bioreactors
#28
JOURNAL ARTICLE
Yohaann Ghosh, Hai Xin, D S Abdullah Al Maruf, Kai Cheng, Innes Wise, Chris Burrows, Ruta Gupta, Veronica Ka-Yan Cheung, James Wykes, David Leinkram, Catriona Froggatt, Will Lewin, Hedi V Kruse, Eva Tomaskovic-Crook, David R McKenzie, Jeremy Micah Crook, Jonathan R Clark
Considerable research is being undertaken to develop novel biomaterials-based approaches for surgical reconstruction of bone defects. This extends to 3D printed materials that provide stable, structural, and functional support in vivo. However, few preclinical models can simulate in vivo human biological conditions for clinically relevant testing. Here we describe a novel ovine model that allows evaluation of in vivo osteogenesis via contact with bone and/or periosteum interfaced with printed polymer bioreactors loaded with biomaterial bone substitutes...
February 18, 2024: Tissue Engineering. Part C, Methods
https://read.qxmd.com/read/38360197/abaloparatide-is-more-potent-than-teriparatide-in-restoring-bone-mass-and-strength-in-type-1-diabetic-male-mice
#29
JOURNAL ARTICLE
Silvia Marino, Serra Ucer Ozgurel, Kevin McAndrews, Meloney Cregor, Alma Villaseñor, Maricuz Mamani-Huanca, Coral Barbas, Arancha Gortazar, Amy Y Sato, Teresita Bellido
This study investigated the efficacy of the two FDA-approved bone anabolic ligands of the parathyroid hormone receptor 1 (PTH1R), teriparatide or human parathyroid hormone 1-34 (PTH) and abaloparatide (ABL), to restoring skeletal health using a preclinical murine model of streptozotocin-induced T1-DM. Intermittent daily subcutaneous injections of equal molar doses (12 pmoles/g/day) of PTH (50 ng/g/day), ABL (47.5 ng/g/day), or vehicle, were administered for 28 days to 5-month-old C57Bl/6 J male mice with established T1-DM or control (C) mice...
February 13, 2024: Bone
https://read.qxmd.com/read/38351667/medieval-monastic-health-variation-in-skeletal-signs-of-inflammation-and-developmental-stress-between-religious-orders-in-london
#30
JOURNAL ARTICLE
Sharon N DeWitte
OBJECTIVES: Previous bioarchaeological analyses of medieval monastic and nonmonastic cemeteries in London revealed evidence of lower risks of mortality, and thus better health, in the monastic settings. However, comparison of the two monastic communities, Bermondsey Abbey and Merton Priory, which adhered to different religious ideals, suggested lower risks of mortality in the former. This study examines patterns of skeletal biomarkers, which reflect developmental stress or inflammation, in an attempt to clarify the possible underlying mechanisms producing apparent health differences in these monastic communities...
February 13, 2024: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://read.qxmd.com/read/38348003/a-rare-case-of-a-subgaleal-hematoma-with-global-developmental-delay-scurvy-and-congenital-toxoplasmosis-rubella-cytomegalovirus-herpes-simplex-and-hiv-torch-infection
#31
Ankita Patel, Jayant D Vagha, Revat J Meshram, Rahul Khandelwal
This case report details the complex presentation of a six-year-old female child with global developmental delay (GDD), scurvy, congenital toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and HIV (TORCH) infection and a subgaleal hematoma. The patient's medical history included delayed developmental milestones, bilateral congenital cataract, and a previous generalized tonic-clonic seizure. Thorough investigations revealed cerebral atrophy, bilateral ventricular dilatation, and periosteal thinning consistent with scurvy...
January 2024: Curēus
https://read.qxmd.com/read/38331449/caffey-s-disease-in-disguise-a-child-abuse-mimic
#32
JOURNAL ARTICLE
Himanshu Gupta, Bharat Choudhary
A male infant was brought in a paediatric emergency with swelling in the right hand associated with restriction of wrist movements. Examination confirmed similar findings. The history of trauma was not forthcoming. Given the ambiguous history, the possibility of child abuse was kept. X-ray showed local soft tissue swelling with periosteal thickening and raised inflammatory markers in blood tests, which on review of the literature, was consistent with Caffey disease. Due to the self-limiting nature of the condition, the child was managed conservatively...
February 7, 2024: BMJ Case Reports
https://read.qxmd.com/read/38319960/modified-mustard%C3%A3-and-superolateral-periosteal-flaps-for-full-thickness-defects-of-medial-and-central-lower-eyelid-a-case-series
#33
JOURNAL ARTICLE
Pattana Ongkasuwan
BACKGROUND: Reconstructing full-thickness defects involving 50% to 75% of the horizontal length of the lower eyelid after medial and central full-thickness block resection can be challenging. As a disadvanatge, 1-stage reconstructions may require a free graft reconstruction of the posterior lamella. In addition, 2-stage reconstructions are associated with several complications, including erythema, and the eye must be temporarily closed after surgery. METHODS: The present study describes a single-surgeon retrospective case series...
January 25, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38304659/monostotic-scapular-caffey-disease-a-case-report-with-mri-correlate
#34
Madhu Oad, Jonathan Tu, Bilal Siddiqui, Dan Barlev, Salman Shah
Caffey disease, also referred to as infantile cortical hyperostosis, is a self-limiting inflammatory disease of bone, typically diagnosed in infancy (ages less than five months). This disease is characterized by asymmetric, often polyostotic bony hyperostosis and expansion, with a predilection for the mandible (70-90%). We present a unique case of a two-month-old boy with monostotic scapular hyperostosis. The disease is primarily diagnosed on plain film and further evaluated with bone scintigraphy or skeletal survey to identify the extent of osseous involvement...
January 2024: Curēus
https://read.qxmd.com/read/38303650/effects-of-long-term-voluntary-wheel-running-and-selective-breeding-for-wheel-running-on-femoral-nutrient-canals
#35
JOURNAL ARTICLE
Brandon B Tan, Nicole E Schwartz, Lynn E Copes, Theodore Garland
The nutrient artery provides ~50%-70% of the total blood volume to long bones in mammals. Studying the functional characteristics of this artery in vivo can be difficult and expensive, so most researchers have measured the nutrient foramen, an opening on the outer surface of the bone that served as the entry point for the nutrient artery during development and bone ossification. Others have measured the nutrient canal (i.e., the passage which the nutrient artery once occupied), given that the external dimensions of the foramen do not necessarily remain uniform from the periosteal surface to the medullary cavity...
February 2, 2024: Journal of Anatomy
https://read.qxmd.com/read/38289626/guided-bone-regeneration-novel-use-of-fixation-screws-as-an-alternative-to-using-the-buccoapical-periosteum-for-membrane-stabilization-with-sutures-two-case-reports
#36
JOURNAL ARTICLE
Matthew J Fien, Israel Puterman, Juan Mesquida, Ignacio Ginebreda, Guillermo Bauza
Guided bone regeneration (GBR) requires a stable graft-membrane complex. This article presents a novel technique that uses membrane fixation screws to serve as anchors for membrane stabilization sutures without the need for periosteal dissection and biting of the buccoapical periosteum. This technique may be a viable alternative when there is a preference to avoid the complexities of periosteal suturing and direct membrane fixation using tacks or screws. The technique, which utilizes anchoring screws as mooring lines, can be used at the time of tooth extraction as well as for ridge augmentation of an edentulous site in preparation for future dental implant placement...
February 2024: Compendium of Continuing Education in Dentistry
https://read.qxmd.com/read/38288029/a-case-of-osteopetrosis-with-orbital-inflammation-secondary-to-maxillary-osteomyelitis
#37
Takafumi Misaki, Fumiko Murao, Kayo Shinomiya, Akihiro Tani, Masayuki Yamada, Yoshinori Mitamura
INTRODUCTION: Osteopetrosis is a rare heritable disorder characterized by increased bone density resulting from osteoclast dysfunction. Major complications include bone fracture, osteomyelitis, anemia, and cranial nerve compression. Optic atrophy can occur due to compression of the optic nerve. Although osteomyelitis of the jaw is a common complication, it rarely occurs in the maxilla. Here, we report a case of a 74-year-old female with osteopetrosis who developed maxillary osteomyelitis, leading to orbital inflammation...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38283429/hypertrophic-osteoarthropathy-a-case-of-an-undifferentiated-polyarthritis
#38
Margarida M Carvalho, Sara Raimundo
Hypertrophic osteoarthropathy is a paraneoplastic syndrome and is considered an important secondary cause of rheumatic disease. It typically manifests as tibial and femoral bone pain, with arthralgia or synovitis of adjacent joints also being common findings. Usually, musculoskeletal symptoms accompany the course of the disease, disappearing with treatment of the neoplasm and recurring coincidentally with the tumor relapse. The authors report a case of a patient with hypertrophic osteoarthropathy, whose etiological study allowed the diagnosis of a lung adenocarcinoma, particularly challenging due to the patient's young age and the absence of associated symptoms...
December 2023: Curēus
https://read.qxmd.com/read/38282291/frequency-shifts-of-free-water-signals-from-compact-bone-simulations-and-measurements-using-a-ute-fid-sequence
#39
JOURNAL ARTICLE
Anja Fischer, Petros Martirosian, Jürgen Machann, Bernd Fränkle, Fritz Schick
PURPOSE: Free water in cortical bone is either contained in nearly cylindrical structures (mainly Haversian canals oriented parallel to the bone axis) or in more spherically shaped pores (lacunae). Those cavities have been reported to crucially influence bone quality and mechanical stability. Susceptibility differences between bone and water can lead to water frequency shifts dependent on the geometric characteristics. The purpose of this study is to calculate and measure the frequency distribution of the water signal in MRI in dependence of the microscopic bone geometry...
January 28, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38278679/analgesic-techniques-for-managing-orthopedic-injuries-a-review-for-the-emergency-clinician
#40
JOURNAL ARTICLE
Brit Long, Rachel E Bridwell, Michael Gottlieb
BACKGROUND: Orthopedic injuries are commonly managed in the emergency department (ED) setting. Fractures and dislocations may require reduction for proper management. There are a variety of analgesic and sedative strategies to provide patient comfort during reduction. OBJECTIVE: This narrative review evaluates hematoma block, intra-articular injection, intravenous regional analgesia (IVRA) (also known as the Bier block), and periosteal block for orthopedic analgesia in the ED setting...
October 7, 2023: Journal of Emergency Medicine
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