Yohaann Ghosh, Hai Xin, D S Abdullah Al Maruf, Kai Cheng, Innes Wise, Chris Burrows, Ruta Gupta, Veronica Ka-Yan Cheung, James Wykes, David Leinkram, Catriona Froggatt, Will Lewin, Hedi V Kruse, Eva Tomaskovic-Crook, David R McKenzie, Jeremy Micah Crook, Jonathan R Clark
Considerable research is being undertaken to develop novel biomaterials-based approaches for surgical reconstruction of bone defects. This extends to 3D printed materials that provide stable, structural, and functional support in vivo. However, few preclinical models can simulate in vivo human biological conditions for clinically relevant testing. Here we describe a novel ovine model that allows evaluation of in vivo osteogenesis via contact with bone and/or periosteum interfaced with printed polymer bioreactors loaded with biomaterial bone substitutes...
February 18, 2024: Tissue Engineering. Part C, Methods