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https://www.readbyqxmd.com/read/29774894/value-of-diffusion-weighted-imaging-for-monitoring-tissue-change-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-therapy-in-bone-applications-an-ex-vivo-study
#1
Sharon L Giles, Jessica M Winfield, David J Collins, Ian Rivens, John Civale, Gail R Ter Haar, Nandita M deSouza
Background: Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) can palliate metastatic bone pain by periosteal neurolysis. We investigated the value of diffusion-weighted imaging (DWI) for monitoring soft tissue changes adjacent to bone during MR-guided HIFU. We evaluated the repeatability of the apparent diffusion coefficient (ADC) measurement, the temporal evolution of ADC change after sonication, and its relationship with thermal parameters. Methods: Ex-vivo experiments in lamb legs ( n = 8) were performed on a Sonalleve MR-guided HIFU system...
2018: European radiology experimental
https://www.readbyqxmd.com/read/29774790/clear-cell-chondrosarcoma-with-chondroblastoma-like-features-a-case-for-team-diagnosis
#2
Ryan M Kiefer, John Wojcik, Kumarasen Cooper, Kristy L Weber, Ronnie Sebro
Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an osteolytic lesion with adjacent area of sclerosis in the proximal left femur. Magnetic resonance imaging demonstrated a marrow-infiltrative lesion with periosteal reaction and thickened enhancing periosteum...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29764788/periosteal-flap-in-cochlear-implantation-how-i-do-it
#3
Yasser Ahmed Fouad, Thomas Roland
This clinical report describes and evaluates a novel periosteal flap design. This technique was applied in 26 patients who underwent cochlear implantation surgery at two tertiary referral centers. No complications were observed during or after the surgery. Additionally, there was no evidence of device migration, wound infection, wound hematoma, or delayed wound healing. Notably, the mastoid emissary vein was intact in all cases. In conclusion, this modified anterior-based periosteal flap is a safe procedure and is aimed at avoiding mastoid emissary vein bleeding and allowing complete repositioning of the periosteum over the implanted device...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29762846/neurotrophin-3-improves-fracture-healing-in-rats
#4
X Li, D-C Sun, Y Li, X-Y Wu
OBJECTIVE: This study aimed at investigating the role of Neurotrophin-3 (NT-3) in the bone fracture healing of rats and to provide a reference for clinical treatment. MATERIALS AND METHODS: 40 Sprague-Dawley (SD) rats were randomly divided into control group and NT-3 group. The tibia fracture model was made in NT-3 group, and the tibia bone mineral density (BMD) was measured before and after the surgery. The biomechanics indexes were inspected after the surgery, including elasticity modulus, max load, and bending rigidity...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29759083/hypertrophic-osteoarthropathy-mimicking-a-reactive-arthritis-a-case-report-and-review-of-the-literature
#5
Francesco Bozzao, Stella Bernardi, Franca Dore, Lorenzo Zandonà, Fabio Fischetti
BACKGROUND: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. CASE PRESENTATION: A 77-year-old man presented with fever, diarrhea, and an oligoarthritis involving the left knee and the ankles...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#6
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29751744/a-case-of-raine-syndrome-presenting-with-facial-dysmorphy-and-review-of-literature
#7
Jayesh Sheth, Riddhi Bhavsar, Ajit Gandhi, Frenny Sheth, Dhairya Pancholi
BACKGROUND: Raine syndrome (RS) - an extremely rare autosomal recessive genetic disorder, is caused by a biallelic mutation in the FAM20C gene. Some of the most common clinical features include generalized osteosclerosis with a periosteal bone formation, dysmorphic face, and thoracic hypoplasia. Many cases have also been reported with oro-dental abnormalities, and developmental delay. Most of the cases result in neonatal death. However, a few non-lethal RS cases have been reported where patients survive till adulthood and exhibits a heterogeneous clinical phenotype...
May 11, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29751129/selective-inhibition-of-src-family-kinases-by-su6656-increases-bone-mass-by-uncoupling-bone-formation-from-resorption-in-mice
#8
Cyril Thouverey, Serge Ferrari, Joseph Caverzasio
Mice deficient in the non-receptor tyrosine kinase Src exhibit high bone mass due to impaired bone resorption and increased bone formation. Although several Src family kinase inhibitors inhibit bone resorption in vivo, they display variable effects on bone formation. SU6656 is a selective Src family kinase inhibitor with weaker activity towards the non-receptor tyrosine kinase Abl and receptor tyrosine kinases which are required for appropriate osteoblast proliferation, differentiation and function. Therefore, we sought to determine whether SU6656 could increase bone mass by inhibiting bone resorption and by stimulating bone formation, and to explore its mechanisms of action...
May 8, 2018: Bone
https://www.readbyqxmd.com/read/29747053/use-of-acellular-collagen-matrix-for-the-closure-of-the-open-oral-wound-in-bone-regeneration
#9
Dragan Stankovic, Milica Labudovic-Borovic, Radoslav Radosavljevic, Milos Marinkovic, Esma R Isenovic
Mucograft is collagen matrix was designed for use in open healing situations due to its compact outer layer. The technique presented in this article is an attempt to avail this attribute for covering open oral wound in guided bone regeneration (GBR) procedure. The essential idea of this technique is to avoid scoring of periosteum, submucosa and muscle layer for buccal flap advancement. Therefore, we used mucograft to cover bone substitute and barrier membrane in GBR surgical procedure. Thus, we avoided periostal-releasing incisions (PRI) and gained reposition of the flap to original level without impairing the attached keratinized gingiva...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29744191/synergistic-effects-of-the-combined-use-of-human-cultured-periosteal-sheets-and-platelet-rich-fibrin-on-bone-regeneration-an-animal-study
#10
Makoto Horimizu, Takehiko Kubota, Tomoyuki Kawase, Masaki Nagata, Mito Kobayashi, Kazuhiro Okuda, Koh Nakata, Hiromasa Yoshie
A human-cultured alveolar bone-derived periosteal (hCP) sheet is an osteogenic grafting material used clinically in periodontal regenerative therapy, while platelet-rich fibrin (PRF), a platelet concentrate with fibrin clot, is considered to augment the wound healing process. Therefore, whether the combined use of hCP-PRF complex could facilitate bone regeneration synergistically was evaluated in animal models. Human periosteal segments (1 × 1 mm) were cultured initially on plastic dishes and formed an hCP sheet...
August 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29742594/capillary-hemangioma-as-an-unusual-cause-of-doughnut-sign-on-bone-scan
#11
Omar Q Samarah, Mohammad I Tayyem, Nisreen Abu Shahin, Ghadeer AlMuhaisen, Malik E Juweid
A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. This case demonstrates that the doughnut sign on bone scan can be caused by capillary hemangioma in addition to other reported bone pathologies, including aneurysmal bone cyst, giant cell tumor, and telangiectatic osteosarcoma...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29737414/bone-geometry-in-young-male-and-female-football-players-a-peripheral-quantitative-computed-tomography-pqct-study
#12
Gabriel Lozano-Berges, Ángel Matute-Llorente, Alejandro Gómez-Bruton, Alex González-Agüero, Germán Vicente-Rodríguez, José A Casajús
The present study shows that football practice during growth may improve bone geometry in male and female football players. However, only females had better bone strength in comparison with controls. PURPOSE: The aim of this study was to compare bone geometry in adolescent football players and controls. METHODS: A total of 107 football players (71 males/36 females; mean age 12.7 ± 0.6/12.7 ± 0.6 years) and 42 controls (20 males/22 females; mean age 13...
May 8, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29734907/omega-%C3%AE-pulley-plasty-for-surgical-management-of-dequervain-s-disease
#13
Joseph Bakhach, Bachar Chaya, Nazareth Papazian
BACKGROUND: DeQuervain tenosynovitis, refractory to medical conservative treatment, has been traditionally treated by a simple division of the pulley, a procedure associated with several complications. Many authors attempted to prevent these complications by describing techniques of pulley reconstruction after its release necessitating suturing the different flaps and subsequently promoting extensor tendons adhesions. The authors present an alternative procedure for the first extensor compartment pulley decompression: "Omegaplasty"...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29734891/hemi-hamate-autograft-arthroplasty-for-the-proximal-interphalangeal-joint-revisited-a-new-surgical-approach
#14
Patrick K Y Goon, Kalpesh R Vaghela, Shirley Stougie, Jan H Coert
The hemi-hamate arthroplasty for proximal interphalangeal joint (PIPJ) dorsal fracture dislocations relies on complete dislocation of the joint using the 'shotgun' approach which provides excellent exposure but damages the delicate intrinsic joint stabilisers. We present a new approach to the PIPJ when performing the hemi-hamate arthroplasty. The volar surgical approach involves freeing up the whole tendon sheath-periosteal unit as a single layer, and retracting this to one side. The articular surface of the joint can then be accessed with a little distraction and hyperextension...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29730467/micro-anatomical-structure-of-the-first-spine-of-the-dorsal-fin-of-atlantic-bluefin-tuna-thunnus-thynnus-osteichthyes-scombridae
#15
Nicoletta Santamaria, Giambattista Bello, Letizia Passantino, Mariasevera Di Comite, Rosa Zupa, Chrysovalentinos Pousis, Robert Vassallo-Agius, Vincenzo Cicirelli, Gualtiero Basilone, Salvatore Mangano, Aldo Corriero
The first spine of the first dorsal fin (FS) of the Atlantic bluefin tuna (ABFT), Thunnus thynnus, is customarily used in age determination research because its transverse sections display well-defined growth marks. In this paper the FS structure was studied to explain its known dramatic age- and season-related morphological modifications, which are evidently caused by bone remodeling. Cross sections of samples from six adult ABFT were in part decalcified to be stained with histological, histochemical and immunohistochemical methods, and in part embedded in methyl-methacrylate to be either observed under a linear polarized light or microradiographed...
May 3, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29720540/porcupine-inhibitors-impair-trabecular-and-cortical-bone-mass-and-strength-in-mice
#16
Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic, Claes Ohlsson
WNT signalling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health are unknown, we determined their effects on bone mass and strength. Twelve-week-old C57BL/6N female mice were treated by the Porcupine inhibitors LGK974 (Low dose = 3 mg/kg/day; High dose = 6 mg/kg/day) or Wnt-C59 (10 mg/kg/day) or vehicle for three weeks...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29713797/whole-egg-consumption-and-cortical-bone-in-healthy-children
#17
L M Coheley, J M Kindler, E M Laing, A Oshri, K M Hill Gallant, S J Warden, M Peacock, C M Weaver, R D Lewis
Eggs contain bioactive compounds thought to benefit pediatric bone. This cross-sectional study shows a positive link between childhood egg intake and radius cortical bone. If randomized trials confirm our findings, incorporating eggs into children's diets could have a significant impact in preventing childhood fractures and reducing the risk of osteoporosis. INTRODUCTION: This study examined the relationships between egg consumption and cortical bone in children. METHODS: The cross-sectional study design included 294 9-13-year-old black and white males and females...
April 30, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29704727/how-do-skeletons-with-hiv-present-a-study-on-the-identified-cal-milano-cemetery-skeletal-collection
#18
Lucie Biehler-Gomez, Antonio Cabrini, Danilo De Angelis, Cristina Cattaneo
With the Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS) pandemic, the study of HIV/AIDS on bones has become of pivotal interest for research in bone pathologies, forensic applications (especially in the matter of identification when confronted to antemortem data) and medical purposes. In this paper, we document and discuss the macroscopic lesions found on the skeletons of nine individuals with known HIV, including four with known AIDS, coming from the identified CAL Milano Cemetery Skeletal Collection...
April 24, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29702989/the-application-of-x-ray-computed-tomography-and-magnetic-resonance-imaging-on-22-pediatric-langerhans-cell-histiocytosis-patients-with-long-bone-involvement-a-retrospective-analysis
#19
Xiaojun Zhang, Jing Zhou, Xuee Chai, Guiling Chen, Bin Guo, Lei Ni, Peng Wu
The studies focusing on x-ray, computed tomography (CT), and magnetic resonance imaging (MRI) in pediatric Langerhans cell histiocytosis (LCH) patients were still rare. Therefore, we aimed to evaluate the application of x-ray, CT, and MRI in pediatric LCH patients with long bone involvement.Total 22 pediatric LCH patients were included in this study. The diagnosis of LCH was confirmed by pathological examination. All patients were followed up for 3 years. X-ray, CT, or MRI was performed and the results were recorded for further analyses...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29701926/associations-between-lean-mass-muscle-strength-and-power-and-skeletal-size-density-and-strength-in-older-men
#20
Didier Chalhoub, Robert Boudreau, Susan Greenspan, Anne B Newman, Joseph Zmuda, Andrew W Frank-Wilson, Nayana Nagaraj, Andrew R Hoffman, Nancy E Lane, Marcia L Stefanick, Elizabeth Barrett-Connor, Tien Dam, Peggy Cawthon, Eric Orwoll, Jane A Cauley
Studies examining the relationship between muscle parameters and bone strength have not included multiple muscle measurements and/or both central and peripheral skeletal parameters. The purpose of this study was to explore the relationship between lean mass, muscle strength and power, and skeletal size, bone density and bone strength. We studied the association between appendicular lean mass (ALM), grip strength and leg power, and central quantitative computed tomography (QCT) parameters in 2,857 men aged 65 or older; peripheral QCT was available on a subset (N = 786)...
April 27, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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