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https://www.readbyqxmd.com/read/28630846/chronic-recurrent-multifocal-osteomyelitis-a-case-report-with-atypical-presentation
#1
Miguel Pádua Figueiredo, Marco Pato, Fernando Amaral
INTRODUCTION: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory condition. The clinical picture consists of sterile osteomyelitis, typically with multiple-site lesions in the metaphysis of long bones and not uncommonly, symmetrical bone involvement. It is a poorly understood entity, whose prognosis, etiology and ideal treatment are still controversial. The authors report a case of unifocal presentation with an atypical location. CASE REPORT: A previously healthy 12-year-old Caucasian girl came to our institution due to progressive pain on her left thigh for the previous 3 months...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28628357/continuous-periosteal-strapping-sutures-cpss-for-fixation-of-osseous-grafts-with-resorbable-membranes-for-buccal-ridge-augmentation
#2
Tamir Shalev, Gregori M Kurtzman, Alon H Shalev, Deborah K Johnson, Mark Elias Kersten
GBR is a technique sensitive procedure that routinely involves placement of particulate bone with or without fixation screws and either a resorbable or a non-resorbable membrane. Grafting of the buccal-crestal aspect of the implant site can be particularly challenging as external pressure from the flap or occlusal forces may displace the graft laterally and apically resulting in deficient bone in the desired region. A novel technique for stabilizing a resorbable membrane and underlying particulate graft allowing for predictable bone grafting across multiple edentulous sites...
June 19, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28627474/sox9-positive-periosteal-cells-in-fracture-repair-of-the-adult-mammalian-long-bone
#3
Xinjun He, Sofia Bougioukli, Brandon Ortega, Eric Arevalo, Jay R Lieberman, Andrew P McMahon
INTRODUCTION: The phases of fracture healing have been well characterized. However, the exact source and genetic profile of the skeletal progenitors that participate in bone repair is somewhat unclear. Sox9 expression in skeletal elements precedes bone and cartilage formation and a Sox9(+) cell type is retained in the adult periosteum. We hypothesized that Sox9(+) periosteal cells are multipotent skeletal progenitors normally participating in fracture repair. METHODS: To test this hypothesis we used tamoxifen (TM)-mediated lineage tracing of Sox9(+) cells in Sox9CreErt2:Td-Tomato mice...
June 13, 2017: Bone
https://www.readbyqxmd.com/read/28623408/plexiform-neurofibroma-causing-an-ossifying-subperiosteal-haematoma-a-rare-case-in-the-tibia-of-an-11-year-old-girl
#4
Anton Lavell, Christopher W Jones, Daniel Wong, Peter Counsel, Richard Carey-Smith
Ossifying subperiosteal haematoma is an exceedingly rare manifestation of Neurofibromatosis type 1 (NF-1). We report an interesting case of plexiform neurofibroma causing a rapidly growing tibial mass as a result of subperiosteal haemorrhage, in an 11-year-old girl with previously undiagnosed NF-1. This reflects a precursor of the more mature periosteal ossification seen in cases traditionally termed "subperiosteal cysts". A previously well young girl was referred by her general practitioner with an increasingly large, mildly tender, soft lump on the anterior aspect of her right tibia...
June 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28614530/chronic-recurrent-multifocal-osteomyelitis-exhibiting-predominance-of-periosteal-reaction
#5
Rodolfo Mendes Queiroz, Pedro Henrique Pereira Rocha, Lara Zupelli Lauar, Mauro José Brandão da Costa, Claudio Benedini Laguna, Rafael Gouvêa Gomes de Oliveira
Chronic recurrent multifocal osteomyelitis is an idiopathic nonpyogenic autoinflammatory bone disorder involving multiple sites, with clinical progression persisting for more than 6 months and which may have episodes of remission and exacerbation in the long term. It represents up to 2-5% of the cases of osteomyelitis, with an approximate incidence of up to 4/1,000,000 individuals, and average age of disease onset estimated between 8-11 years, predominantly in females. The legs are the most affected, with a predilection for metaphyseal regions along the growth plate...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28614210/congenital-syphilis-of-bone-a-potential-mimicker-of-childhood-histiocytoses
#6
Youran Zou, Matthew A Marcus, C Guy Castles, Scott E Kilpatrick
Involvement of the skeletal system by congenital syphilis is well documented in the literature, chiefly in the form of radiologic studies, including periostitis, osteitis, and osteochondritis. Because congenital syphilis is generally recognized clinically, tissue biopsy is virtually never performed. Therefore, the histopathologic findings are less well documented and mostly exist in the older literature. We report herein the clinicoradiologic and pathologic features of a 2-month-old infant who initially presented with absence of left arm movement...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28607813/differential-involvement-of-wnt-signaling-in-bmp-regulation-of-cancellous-versus-periosteal-bone-growth
#7
Guangxu He, Yu Shi, Joohyun Lim, Teresita Bellido, Jiangdong Ni, Fanxin Long
Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood. We have recently shown that deletion of the receptor Bmpr1a in the osteoblast lineage with Dmp1-Cre reduces osteoblast activity in general but stimulates proliferation of preosteoblasts specifically in the cancellous bone region, resulting in diminished periosteal bone growth juxtaposed with excessive cancellous bone formation...
2017: Bone Research
https://www.readbyqxmd.com/read/28606438/periosteal-elevation-induces-supracortical-peri-implant-bone-formation
#8
Rainer Lutz, Christina Sendlbeck, Hommeira Wahabzada, Christian Tudor, Christopher Prechtl, Karl Andreas Schlegel
PURPOSE: The aim of the study was to evaluate the possibility of supracortical peri-implant bone formation after periosteal elevation. MATERIALS AND METHODS: Periosteal elevation with an elevation height of 5 or 10 mm was performed in an animal experiment with 24 female domestic pigs. For this purpose, four implants were inserted in the frontal bone of each animal. The implants protruded from the local bone by 5 or 10 mm. In the test groups, the periosteum was attached to the protruding implants...
May 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28604551/the-periosteal-medial-femoral-condyle-free-flap-a-new-option-for-soft-tissue-reconstruction-of-the-distal-lower-extremity
#9
Noah H Saad, Matthew E Pontell, Brian S Winters, Joseph Daniel, Adam Saad
BACKGROUND: Small (<30 cm) soft tissue defects of the distal leg, foot, and ankle pose a complicated issue with regard to wound healing. Multiple flaps have been proposed for reconstruction of these wounds with varying levels of success. The medial femoral condyle flap is a free bone flap supplied by the descending geniculate artery. It is currently used in the treatment of fracture nonunion, infected bone defects, avascular necrosis, and osteoradionecrosis. This study proposes the use of the periosteal portion of the medial femoral condyle (PMFC) flap for soft tissue reconstruction of the distal leg, foot, and ankle...
June 9, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28597139/hypoxia-and-bone-metastatic-disease
#10
REVIEW
Rachelle W Johnson, Miranda E Sowder, Amato J Giaccia
PURPOSE OF REVIEW: This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow. RECENT FINDINGS: The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain...
June 8, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28589157/return-to-preoperative-function-after-autologous-cartilage-implantation-of-the-knee-in-active-military-servicemembers
#11
Nicholas J Zarkadis, Nicholas A Kusnezov, EStephan J Garcia, Mark P Pallis, Brian R Waterman
BACKGROUND: Autologous chondrocyte implantation (ACI) has been shown to provide adequate durability, pain relief, and improved long-term functional outcomes in the average patient, but proof of its efficacy in individuals with greater than average physical demands is scarce. Further knowledge is required to understand which patients may benefit from ACI and to identify which risk factors are associated with failure to return to the preinjury activity level. PURPOSE: To determine the occupational outcomes, rates of reoperation, and variables predictive of suboptimal outcomes after ACI...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28587611/chronic-recurrent-multifocal-osteomyelitis-beginning-with-a-solitary-lesion-of-the-ilium
#12
Ping Zhang, Xiao Ying Jia, Yun Zhang, John Morelli, Ze Kun Zhang
BACKGROUND: Chronic recurrent multifocal osteomyelitis (CRMO) is an idiopathic inflammatory disease. The initial lesions are typically found in the metaphyses, generally without periosteal reaction. CASE PRESENTATION: We present a case of a 14-year-old female teenager with relapsing and remitting right iliac pain. There was no evidence of infectious organisms, neoplastic processes, or hematologic malignancy based on laboratory tests. Initial computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated atypical periosteal proliferation in the right ilium...
June 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28583783/presentaciones-poco-comunes-y-peligros-de-la-s%C3%A3-filis-secundaria-periosteitis-tenosinovitis-y-anomal%C3%A3-as-hep%C3%A3-ticas
#13
Diana Rosa-Gonçalves, Miguel Bernardes, Lúcia Costa
We herein describe two cases of secondary syphilis in patients with human immunodeficiency virus (HIV) infection with an unusual presentation, a diffuse polyostotic periosteitis. Patients referred mainly intense bone pain. Other relevant aspects of the clinical pictures were flexor tenosynovitis and hepatic abnormalities. Given the persistence of symptoms, the treatment duration performed was different from most described in literature. However, although more slowly than expected, both obtained a favorable clinical response after treatment with benzathine penicillin G...
June 2, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28580385/modeling-and-remodeling-effects-of-intermittent-administration-of-teriparatide-parathyroid-hormone-1-34-on-bone-morphogenetic-protein-induced-bone-in-a-rat-spinal-fusion-model
#14
Takashi Kaito, Tokimitsu Morimoto, Sadaaki Kanayama, Satoru Otsuru, Masafumi Kashii, Takahiro Makino, Kazuma Kitaguchi, Masayuki Furuya, Ryota Chijimatsu, Kosuke Ebina, Hideki Yoshikawa
BACKGROUND: Bone morphogenetic protein (BMP)-based tissue engineering has focused on inducing new bone efficiently. However, modeling and remodeling of BMP-induced bone have rarely been discussed. Teriparatide (parathyroid hormone [PTH] 1-34) administration initially increases markers of bone formation, followed by an increase in bone resorption markers. This unique activity would be expected to accelerate the modeling and remodeling of new BMP-induced bone. METHODS: Male Sprague-Dawley rats underwent posterolateral spinal fusion surgery and implantation of collagen sponge containing either 50 μg recombinant human (rh)BMP-2 or saline...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28574653/cortical-and-trabecular-bone-microstructure-did-not-recover-at-weight-bearing-skeletal-sites-and-progressively-deteriorated-at-non-weight-bearing-sites-during-the-year-following-international-space-station-missions
#15
Laurence Vico, Bert Van Rietbergen, Nicolas Vilayphiou, Marie-Thérèse Linossier, Hervé Locrelle, Myriam Normand, Mohamed Zouch, Maude Gerbaix, Nicolas Bonnet, Valery Novikov, Thierry ThomC, Galina Vassilieva
Risk for premature osteoporosis is a major health concern in astronauts and cosmonauts and the reversibility of the bone lost at the weight-bearing bone sites is not established although it is suspected to take longer than the mission length. The bone three-dimensional structure and strength which could be uniquely affected by weightlessness, is currently unknown. Our objective is to evaluate bone mass, microarchitecture and strength of weight- and non-weight-bearing bone in 13 cosmonauts before and for 12 months after 4-6-month sojourn in the International Space Station (ISS)...
June 2, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28572612/one-month-spaceflight-compromises-the-bone-microstructure-tissue-level-mechanical-properties-osteocyte-survival-and-lacunae-volume-in-mature-mice-skeletons
#16
Gerbaix Maude, Gnyubkin Vasily, Farlay Delphine, Olivier Cécile, Ammann Patrick, Courbon Guillaume, Laroche Norbert, Gential Rachel, Follet Hélène, Peyrin Françoise, Shenkman Boris, Gauquelin-Koch Guillemette, Vico Laurence
The weightless environment during spaceflight induces site-specific bone loss. The 30-day Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after spaceflight and an 8-day recovery period in mature male C57/BL6 mice. In the femur metaphysis, spaceflight decreased the trabecular bone volume (-64% vs. Habitat Control), dramatically increased the bone resorption (+140% vs. Habitat Control) and induced marrow adiposity invasion. At the diaphysis, cortical thinning associated with periosteal resorption was observed...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28566782/early-results-of-an-intraosseous-device-for-arthrodesis-of-the-hallux-metatarsophalangeal-joint
#17
Efstathios Drampalos, Shen Hwa Vun, Levent Bayam, Irfan Fayyaz
BACKGROUND: Arthrodesis of the hallux metatarsophalangeal (MTP) joint is commonly done as a primary procedure either to correct severe hallux valgus deformities or for rheumatoid arthritis, hallux rigidus, in patients with neuromuscular disorders and as a salvage procedure for failed bunion surgery or infection. Prominent metalwork frequently can cause soft tissue impingement and thus require removal. In contrast, osteosynthesis with a completely intraosseous implant has the advantage of less damage to the periosteal circulation...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28562645/characterization-of-single-cell-derived-cultures-of-periosteal-progenitor-cells-to-ensure-the-cell-quality-for-clinical-application
#18
Stefan Stich, Alexander Loch, Su-Jin Park, Thomas Häupl, Jochen Ringe, Michael Sittinger
For clinical applications of cells and tissue engineering products it is of importance to characterize the quality of the used cells in detail. Progenitor cells from the periosteum are already routinely applied in the clinics for the regeneration of the maxillary bone. Periosteal cells have, in addition to their potential to differentiate into bone, the ability to develop into cartilage and fat. However, the question arises whether all cells isolated from periosteal biopsies are able to differentiate into all three tissue types, or whether there are subpopulations...
2017: PloS One
https://www.readbyqxmd.com/read/28561381/estrogen-dependent-efficacy-of-limb-ischemic-preconditioning-in-female-rats
#19
Levente Pócs, Ágnes Janovszky, Dénes Garab, Gabriella Terhes, Imre Ocsovszki, József Kaszaki, Mihály Boros, József Piffkó, Andrea Szabó
Our aim was to examine the effects of ischemic preconditioning (IPC) on the local periosteal and systemic inflammatory consequences of hindlimb ischemia-reperfusion (IR) in Sprague-Dawley rats with chronic estrogen deficiency (13 weeks after ovariectomy, OVX) in the presence and absence of chronic 17beta-estradiol supplementation (E2, 20 µg kg(-1) , 5 days/week for 5 weeks); sham-operated (non-OVX) animals served as controls. As assessed by intravital fluorescence microscopy, rolling and the firm adhesion of polymorphonuclear neutrophil leukocytes (PMNs) gave similar results in the Sham + IR and OVX + IR groups in the tibial periosteal microcirculation during the 3-h reperfusion period after a 60-min tourniquet ischemia...
May 31, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28555201/reconstruction-of-horizontovertical-alveolar-defects-presentation-of-a-novel-split-thickness-flap-design-%C3%A2-for-guided-bone-regeneration-%C3%A2-a-case-report-with-5-year-follow-up
#20
Peter Windisch, Anna Martin, Arvin Shahbazi, Balint Molnar
OBJECTIVE: To introduce a novel split-thickness flap design without periosteal and vertical releasing incisions for horizontovertical ridge augmentation. METHOD AND MATERIALS: Three patients with generalized chronic periodontitis presented posterior partial edentulism with class C alveolar defects according to the horizontal, vertical, and combination (HVC) classification. In all three cases, implant placement and simultaneous horizontovertical ridge augmentation utilizing a novel split-thickness flap design was performed...
2017: Quintessence International
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