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https://www.readbyqxmd.com/read/27803124/rice-aleurone-layer-specific-osnf-yb1-regulates-grain-filling-and-endosperm-development-by-interacting-with-an-erf-transcription-factor
#1
Jing-Jing Xu, Xiao-Fan Zhang, Hong-Wei Xue
Grain yield and quality of rice mainly depend on grain filling and endosperm development. Here we report that a rice NUCLEAR FACTOR Y (NF-Y) transcription factor, OsNF-YB1, is specifically expressed in the aleurone layer of developing endosperm and regulates grain filling and endosperm development. Knockdown of OsNF-YB1 expression by RNAi significantly retarded grain filling, leading to small grains with chalky endosperm as well as altered starch quality. Whereas OsNF-YB1 shows subcellular localization in both the cytosol and the nucleus in roots, it was specifically targeted to the nucleus of aleurone layer cells, which was facilitated by interacting with OsNF-YC proteins preferentially expressed in the aleurone layer...
November 1, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27694635/muramyl-peptides-activate-innate-immunity-conjointly-via-yb1-and-nod2
#2
Alexander G Laman, Richard Lathe, Anna O Shepelyakovskaya, Alexandra Gartseva, Feodor A Brovko, Svetlana Guryanova, Ludmila Alekseeva, Elena A Meshcheryakova, Vadim T Ivanov
Bacterial cell wall muramyl dipeptide (MDP) and glucosaminyl-MDP (GMDP) are potent activators of innate immunity. Two receptor targets, NOD2 and YB1, have been reported; we investigated potential overlap of NOD2 and YB1 pathways. Separate knockdown of NOD2 and YB1 demonstrates that both contribute to GMDP induction of NF-κB expression, a marker of innate immunity, although excess YB1 led to induction in the absence of NOD2. YB1 and NOD2 co-migrated on sucrose gradient centrifugation, and GMDP addition led to the formation of higher molecular mass complexes containing both YB1 and NOD2...
September 30, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27626073/super-heavy-electron-material-as-metallic-refrigerant-for-adiabatic-demagnetization-cooling
#3
Yoshifumi Tokiwa, Boy Piening, Hirale S Jeevan, Sergey L Bud'ko, Paul C Canfield, Philipp Gegenwart
Low-temperature refrigeration is of crucial importance in fundamental research of condensed matter physics, because the investigations of fascinating quantum phenomena, such as superconductivity, superfluidity, and quantum criticality, often require refrigeration down to very low temperatures. Currently, cryogenic refrigerators with (3)He gas are widely used for cooling below 1 K. However, usage of the gas has been increasingly difficult because of the current worldwide shortage. Therefore, it is important to consider alternative methods of refrigeration...
September 2016: Science Advances
https://www.readbyqxmd.com/read/27591085/therapeutic-nuclear-shuttling-of-yb-1-reduces-renal-damage-and-fibrosis
#4
Jialin Wang, Lydia Gibbert, Sonja Djudjaj, Christina Alidousty, Thomas Rauen, Uta Kunter, Andreas Rembiak, Dieter Enders, Vera Jankowski, Gerald S Braun, Jürgen Floege, Tammo Ostendorf, Ute Raffetseder
Virtually all chronic kidney diseases progress towards tubulointerstitial fibrosis. In vitro, Y-box protein-1 (YB-1) acts as a central regulator of gene transcription and translation of several fibrosis-related genes. However, it remains to be determined whether its pro- or antifibrotic propensities prevail in disease. Therefore, we investigated the outcome of mice with half-maximal YB-1 expression in a model of renal fibrosis induced by unilateral ureteral obstruction. Yb1(+/-) animals displayed markedly reduced tubular injury, immune cell infiltration and renal fibrosis following ureteral obstruction...
August 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27541840/multiband-electronic-transport-in-%C3%AE-yb1-x-sr-x-alb4-x%C3%A2-%C3%A2-%C3%A2-%C3%A2-0-0-19-3-single-crystals
#5
Hyejin Ryu, Milinda Abeykoon, Emil Bozin, Yosuke Matsumoto, S Nakatsuji, C Petrovic
We report on the evidence for the multiband electronic transport in α-YbAlB4 and α-Yb0.81(2)Sr0.19(3)AlB4. Multiband transport reveals itself below 10 K in both compounds via Hall effect measurements, whereas anisotropic magnetic ground state sets in below 3 K in α-Yb0.81(2)Sr0.19(3)AlB4. Our results show that Sr(2+) substitution enhances conductivity, but does not change the quasiparticle mass of bands induced by heavy fermion hybridization.
October 26, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27463217/yb9-xcumg4-x-x-0-034-a-%C3%AE%C2%BA-phase-formed-by-lanthanoids
#6
Serena De Negri, Vitaliy Romaka, Pavlo Solokha, Adriana Saccone, Gerald Giester, Herwig Michor, Peter F Rogl
Atom order in the crystal structures of Yb2Cu2-xMg (x = 0.17; Mo2FeB2-type; P4/mbm; a = 0.75592(2) nm; c = 0.40282(1) nm) and Yb9+xCuMg4-x (x = 0.034; Hf9Mo4B-type; P63/mmc; a = 1.0169(5) nm; c = 1.0290(5) nm) was determined from powder and X-ray single-crystal counter data analyses supported by electron probe microanalyses. Among the group of the so-called κ-phases, Yb9+xCuMg4-x is the first representative formed by a lanthanoid element. The structure of this κ-phase can be viewed as a typical network of corner-connected empty Yb6-octahedra, which encompass Yb6Mg6-icosahedra (filled by a mix of Mg/Yb atoms) and Yb6-trigonal prisms centered by Cu atoms to complete the three-dimensional metal framework...
August 15, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27411484/structure-and-efficient-luminescence-upconversion-of-ln-iii-aromatic-n-oxide-coordination-polymers
#7
Bowie S K Chong, Evan G Moore
A series of lanthanide-based coordination polymers {[Yb1-xErx(4,4'-bpdo)3(H2O)2](CF3SO3)3}∞ were synthesised by solvent diffusion techniques, where 4,4'-bpdo = 4,4'-bipyridine-N,N'-dioxide, and using differing mole fractions of Yb(iii) and Er(iii) which were systematically varied (x = 0, 0.05, 0.20, 0.50 and 1). All of the materials obtained were characterised using elemental analyses, single-crystal X-ray diffraction (SXRD) and solid-state photoluminescence studies. Structurally, the coordination polymers crystallise as an isomorphous series of infinite 2D sheets, which contain two inner sphere water molecules, and are isostructural with a previously characterised homometallic Yb(iii) compound...
August 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27047740/overexpression-of-yb1-c-terminal-domain-inhibits-proliferation-angiogenesis-and-tumorigenicity-in-a-sk-br-3-breast-cancer-xenograft-mouse-model
#8
Jian-Hong Shi, Nai-Peng Cui, Shuo Wang, Ming-Zhi Zhao, Bing Wang, Ya-Nan Wang, Bao-Ping Chen
Y-box-binding protein 1 (YB1) is a multifunctional transcription factor with vital roles in proliferation, differentiation and apoptosis. In this study, we have examined the role of its C-terminal domain (YB1 CTD) in proliferation, angiogenesis and tumorigenicity in breast cancer. Breast cancer cell line SK-BR-3 was infected with GFP-tagged YB1 CTD adenovirus expression vector. An 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) proliferation assay showed that YB1 CTD decreased SK-BR-3 cell proliferation, and down-regulated cyclin B1 and up-regulated p21 levels in SK-BR-3 cells...
January 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27013200/human-helicase-recql4-drives-cisplatin-resistance-in-gastric-cancer-by-activating-an-akt-yb1-mdr1-signaling-pathway
#9
Dongliang Mo, Hongbo Fang, Kaifeng Niu, Jing Liu, Meng Wu, Shiyou Li, Tienian Zhu, Mohammed A Aleskandarany, Arvind Arora, Dileep N Lobo, Srinivasan Madhusudan, Adayabalam S Balajee, Zhenfen Chi, Yongliang Zhao
Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic and chemotherapeutic significance of RECQL4 in human gastric cancer, which has yet to be determined. We observed significant increases in RECQL4 mRNA or protein in >70% of three independent sets of human gastric cancer specimens examined, relative to normal gastric tissues...
May 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26725322/yb-1-is-elevated-in-medulloblastoma-and-drives-proliferation-in-sonic-hedgehog-dependent-cerebellar-granule-neuron-progenitor-cells-and-medulloblastoma-cells
#10
A Dey, M Robitaille, M Remke, C Maier, A Malhotra, A Gregorieff, J L Wrana, M D Taylor, S Angers, A M Kenney
Postnatal proliferation of cerebellar granule neuron precursors (CGNPs), proposed cells of origin for the SHH-associated subgroup of medulloblastoma, is driven by Sonic hedgehog (Shh) and insulin-like growth factor (IGF) in the developing cerebellum. Shh induces the oncogene Yes-associated protein (YAP), which drives IGF2 expression in CGNPs and mouse Shh-associated medulloblastomas. To determine how IGF2 expression is regulated downstream of YAP, we carried out an unbiased screen for transcriptional regulators bound to IGF2 promoters...
August 11, 2016: Oncogene
https://www.readbyqxmd.com/read/26655167/three-dimensional-tumor-spheroids-for-in-vitro-analysis-of-bacteria-as-gene-delivery-vectors-in-tumor-therapy
#11
Annika Osswald, Zhongke Sun, Verena Grimm, Grace Ampem, Karin Riegel, Astrid M Westendorf, Wolfgang Sommergruber, Kerstin Otte, Peter Dürre, Christian U Riedel
BACKGROUND: Several studies in animal models demonstrated that obligate and facultative anaerobic bacteria of the genera Bifidobacterium, Salmonella, or Clostridium specifically colonize solid tumors. Consequently, these and other bacteria are discussed as live vectors to deliver therapeutic genes to inhibit tumor growth. Therapeutic approaches for cancer treatment using anaerobic bacteria have been investigated in different mouse models. In the present study, solid three-dimensional (3D) multicellular tumor spheroids (MCTS) of the colorectal adenocarcinoma cell line HT-29 were generated and tested for their potential to study prodrug-converting enzyme therapies using bacterial vectors in vitro...
2015: Microbial Cell Factories
https://www.readbyqxmd.com/read/26622627/obligate-anaerobic-salmonella-typhimurium-strain-yb1-treatment-on-xenograft-tumor-in-immunocompetent-mouse-model
#12
Bin Yu, Lei Shi, Bao-Zhong Zhang, K E Zhang, Xiao Peng, Han-Ben Niu, Jun-LE Qu
The present authors have previously reported a novel approach to genetically engineer Salmonella typhimurium for the medically important therapeutic strategy of using bacterial agents to target malignant tumors in a breast cancer tumor-bearing nude mouse model. However, studying an immunocompromised mouse model for cancer therapy is insufficient, as certain crucial information about the influence of the immune system may be missing. In the present study, inoculation of the Salmonella strain, YB1, into a colon cancer tumor-bearing immunocompetent mouse model was investigated...
August 2015: Oncology Letters
https://www.readbyqxmd.com/read/26538406/enhancing-the-value-of-free-metals-in-the-synthesis-of-lanthanoid-formamidinates-is-a-co-oxidant-needed
#13
Glen B Deacon, Peter C Junk, Daniel Werner
Treatment of N,N'-bis(aryl)formamidines (ArFormH), N,N'-bis(2,6-difluorophenyl)formamidine (DFFormH) or N,N'-bis(2,6-diisopropylphenyl)formamidine (DippFormH), with europium metal in CH3 CN is an efficient synthesis of the divalent complexes: [{Eu(DFForm)2 (CH3 CN)2 }2 ] (Eu1) or [Eu(DippForm)2 (CH3 CN)4 ] (Eu2). The synthetic method was extended to ytterbium, but the metal required activation by addition of Hg(0) . With DFFormH in CH3 CN, [{Yb(DFForm)2 (CH3 CN)}2 ] (Yb1) was obtained in good yield, and [Yb(DFForm)2 (thf)3 ] (Yb3) was obtained from a synthesis in CH3 CN/THF...
January 4, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26403192/nf-yb1-regulated-expression-of-sucrose-transporters-in-aleurone-facilitates-sugar-loading-to-rice-endosperm
#14
LETTER
Ai-Ning Bai, Xiao-Duo Lu, Dong-Qi Li, Jin-Xin Liu, Chun-Ming Liu
No abstract text is available yet for this article.
March 2016: Cell Research
https://www.readbyqxmd.com/read/26286454/genetically-modified-obligate-anaerobic-salmonella-typhimurium-as-a-therapeutic-strategy-for-neuroblastoma
#15
Zhu-Ling Guo, Bin Yu, Bo-Tao Ning, Shing Chan, Qiu-Bin Lin, James Chun-Bong Li, Jian-Dong Huang, Godfrey Chi-Fung Chan
BACKGROUND: Neuroblastoma currently has poor prognosis, therefore we proposed a new strategy by targeting neuroblastoma with genetically engineered anaerobic Salmonella (Sal-YB1). METHODS: Nude and nonobese diabetic-severe combined immunodeficiency (NOD-SCID) orthotopic mouse models were used, and Sal-YB1 was administered via tail vein. The therapeutic effectiveness, bio-safety, and mechanisms were studied. RESULTS: No mice died of therapy-related complications...
2015: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/26270416/discovery-of-potent-and-selective-rsk-inhibitors-as-biological-probes
#16
Rama Jain, Michelle Mathur, Jiong Lan, Abran Costales, Gordana Atallah, Savithri Ramurthy, Sharadha Subramanian, Lina Setti, Paul Feucht, Bob Warne, Laura Doyle, Stephen Basham, Anne B Jefferson, Mika Lindvall, Brent A Appleton, Cynthia M Shafer
While the p90 ribosomal S6 kinase (RSK) family has been implicated in multiple tumor cell functions, the full understanding of this kinase family has been restricted by the lack of highly selective inhibitors. A bis-phenol pyrazole was identified from high-throughput screening as an inhibitor of the N-terminal kinase of RSK2. Structure-based drug design using crystallography, conformational analysis, and scaffold morphing resulted in highly optimized difluorophenol pyridine inhibitors of the RSK kinase family as demonstrated cellularly by the inhibition of YB1 phosphorylation...
September 10, 2015: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26168478/transcriptional-regulation-of-the-p16-tumor-suppressor-gene
#17
REVIEW
Yojiro Kotake, Madoka Naemura, Chihiro Murasaki, Yasutoshi Inoue, Haruna Okamoto
The p16 tumor suppressor gene encodes a specific inhibitor of cyclin-dependent kinase (CDK) 4 and 6 and is found altered in a wide range of human cancers. p16 plays a pivotal role in tumor suppressor networks through inducing cellular senescence that acts as a barrier to cellular transformation by oncogenic signals. p16 protein is relatively stable and its expression is primary regulated by transcriptional control. Polycomb group (PcG) proteins associate with the p16 locus in a long non-coding RNA, ANRIL-dependent manner, leading to repression of p16 transcription...
August 2015: Anticancer Research
https://www.readbyqxmd.com/read/26147853/the-cold-shock-domain-of-yb-1-segregates-rna-from-dna-by-non-bonded-interactions
#18
Vladislav Kljashtorny, Stanislav Nikonov, Lev Ovchinnikov, Dmitry Lyabin, Nicolas Vodovar, Patrick Curmi, Philippe Manivet
The human YB-1 protein plays multiple cellular roles, of which many are dictated by its binding to RNA and DNA through its Cold Shock Domain (CSD). Using molecular dynamics simulation approaches validated by experimental assays, the YB1 CSD was found to interact with nucleic acids in a sequence-dependent manner and with a higher affinity for RNA than DNA. The binding properties of the YB1 CSD were close to those observed for the related bacterial Cold Shock Proteins (CSP), albeit some differences in sequence specificity...
2015: PloS One
https://www.readbyqxmd.com/read/26045483/conduction-electron-spin-resonance-in-the-%C3%AE-yb1-xfexalb4-0%C3%A2-%C3%A2-%C3%A2-x%C3%A2-%C3%A2-%C3%A2-0-50-and-%C3%AE-lualb4-compounds
#19
L M Holanda, G G Lesseux, E T Magnavita, R A Ribeiro, S Nakatsuji, K Kuga, Z Fisk, S B Oseroff, R R Urbano, C Rettori, P G Pagliuso
β-YbAlB4 has become one of the most studied heavy fermion systems since its discovery due to its remarkable physical properties. This system is the first reported Yb-based heavy-fermion superconductor (HFS) for which the low-T superconducting state emerges from a non-fermi-liquid (NFL) normal state associated with quantum criticality Nakatsuji et al 2008 Nature 4 603. Additionally, it presents a striking and unprecedented electron spin resonance (ESR) signal which behaves as a conduction electron spin resonance (CESR) at high temperatures and acquires features of the Yb(3+) local moment ESR at low temperatures...
July 1, 2015: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/26037219/identification-and-characterization-of-nf-yb-family-genes-in-tung-tree
#20
Susu Yang, Yangdong Wang, Hengfu Yin, Haobo Guo, Ming Gao, Huiping Zhu, Yicun Chen
The NF-YB transcription factor gene family encodes a subunit of the CCAAT box-binding factor (CBF), a highly conserved trimeric activator that strongly binds to the CCAAT box promoter element. Studies on model plants have shown that NF-YB proteins participate in important developmental and physiological processes, but little is known about NF-YB proteins in trees. Here, we identified seven NF-YB transcription factor-encoding genes in Vernicia fordii, an important oilseed tree in China. A phylogenetic analysis separated the genes into two groups; non-LEC1 type (VfNF-YB1, 5, 7, 9, 11, 13) and LEC1-type (VfNF-YB 14)...
December 2015: Molecular Genetics and Genomics: MGG
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