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C Michel-Lopez, O Zapata-Pérez, D González-Mendoza, O Grimaldo-Juarez, C Ceceña-Duran, O Tzintzun-Camacho
For a better understanding of the strategies that are used by Prosopis glandulosa in heavy metal tolerance, the present study evaluated the gene expression of three metallothioneins (MTs; PgMt2-1, PgMt2, and PgMt3) in plants exposed to sub-lethal concentrations of copper. The PgMt2-1, PgMt2, and PgMt3 sequences were homologous to the MT type 2 (isoform 1), Mt2, and Mt3 sequences of other plant species found in GenBank. A reverse transcriptase-polymerase chain reaction showed that treatment with 100 mM Cu(2+) induced a significant increase in PgMt2 and PgMt3 expression during the first 4 h of exposure compared to that of PgMt2-1...
March 16, 2017: Genetics and Molecular Research: GMR
Min Wang, Reynaldo Tzintzun, Mingzhang Gao, Zhidong Xu, Qi-Huang Zheng
The reference standard CX-6258 {(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one, 4a} and its desmethylated precursor N-desmethyl-CX-6258 {(E)-3-((5-(3-(1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)-5-chloroindolin-2-one, 5} for radiolabeling were synthesized from 5-bromo-2-furaldehyde and 3-carboxybenzeneboronic acid in 3 and 4 steps with 29-49% and 24-32% overall chemical yield, respectively. The target tracer [(11)C]CX-6258 {(E)-5-chloro-3-((5-(3-(4-[(11)C]methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one, [(11)C]4a} was prepared from N-desmethyl-CX-6258 (5) with [(11)C]CH3OTf under basic condition (2N NaOH) through N-[(11)C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 40-50% radiochemical yield based on [(11)C]CO2 and decay corrected to end of bombardment (EOB) with 370-1110GBq/μmol specific activity at EOB...
September 15, 2015: Bioorganic & Medicinal Chemistry Letters
Mireya Moya, Edgar G Bautista, Antonio Velázquez-González, Felipe Vázquez-Gutiérrez, Guadalupe Tzintzun, María Elena García-Arreola, Manuel Castillejos, Andrés Hernández
During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls, both not infected with the pandemic strain. Significant concentrations of potentially-toxic elements (lead, mercury, cadmium, chromium, arsenic) along with deficiency of selenium or increased Zn/Cu ratios characterized AH1N1 cases under study when evaluated versus controlled cases...
2013: Scientific Reports
Isabelle Romieu, Nelson Gouveia, Luis A Cifuentes, Antonio Ponce de Leon, Washington Junger, Jeanette Vera, Valentina Strappa, Magali Hurtado-Díaz, Victor Miranda-Soberanis, Leonora Rojas-Bracho, Luz Carbajal-Arroyo, Guadalupe Tzintzun-Cervantes
INTRODUCTION: The ESCALA* project (Estudio de Salud y Contaminación del Aire en Latinoamérica) is an HEI-funded study that aims to examine the association between exposure to outdoor air pollution and mortality in nine Latin American cities, using a common analytic framework to obtain comparable and updated information on the effects of air pollution on several causes of death in different age groups. This report summarizes the work conducted between 2006 and 2009, describes the methodologic issues addressed during project development, and presents city-specific results of meta-analyses and meta-regression analyses...
October 2012: Research Report (Res Rep Health Eff Inst)
L Carbajal-Arroyo, V Miranda-Soberanis, M Medina-Ramón, L Rojas-Bracho, G Tzintzun, P Solís-Gutiérrez, I Méndez-Ramírez, M Hurtado-Díaz, J Schwartz, I Romieu
INTRODUCTION: Consistent evidence has shown a positive association between air pollution and daily mortality among adults. Less is known about its effect on infant mortality and the modification of this association by socioeconomic status (SES). OBJECTIVE: To assess the association of particulate matter with an aerodynamic diameter of ≤10μm (PM(10)) and ozone (O(3)) on infant mortality and its modification by SES. METHODS: We evaluated the relationship of 24 h mean PM(10) and 1h daily maximum O(3) levels with 12 079 all-cause deaths (3903 respiratory deaths) among 1- to 11-month-old infants residing in the Mexico City Metropolitan Area between January 1997 and December 2005 using a case-crossover approach...
August 2011: Journal of Epidemiology and Community Health
Miriam Zuk, Leonora Rojas, Salvador Blanco, Paulina Serrano, Jephte Cruz, Felipe Angeles, Guadalupe Tzintzun, Cynthia Armendariz, Rufus D Edwards, Michael Johnson, Horacio Riojas-Rodriguez, Omar Masera
To evaluate the impact of improved wood burning stoves on indoor air pollution, 53 homes in a rural town in Michoacán, Mexico, were selected from a health intervention study and monitored before and after receiving improved wood-burning stoves. Fine particulate matter--particles with aerodynamic diameter less than 2.5 microm (PM(2.5))--concentrations were measured in the central plaza of the community and in three microenvironments in the home (next to the stove, in the kitchen away from the stove, and outdoor patio)...
May 2007: Journal of Exposure Science & Environmental Epidemiology
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