Yang Gao, Kai Kang, Yan-Song Liu, Na-Na Li, Qiu-Yuan Han, Hai-Tao Liu, Wei-Lan Kong, Xing Zhang, Rui Huang, Zhen-Yu Yang, Zhi-Dong Qi, Jun-Bo Zheng, Ming Li, Hong-Liang Wang, Jia-Yu Li, Rui-Jin Liu, Si-Cong Wang, Wei-Hua Zhang, Ming-Yan Zhao, Kai-Jiang Yu
This study aimed to investigate the effect of splenectomy on dexmedetomidine-activated cholinergic anti-inflammatory pathway-mediated alleviation of LPS-induced AKI. A mouse model of septic kidney injury was established in C57BL/6 mice. A total of 30 C57BL/6 mice were randomly divided into the control group, LPS group, dexmedetomidine + LPS group, splenectomy group, splenectomy + LPS group, and splenectomy + dexmedetomidine + LPS group. The pathological effects in kidney tissues in each group were analyzed by HE staining...
April 2021: Inflammation