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Ertapenem

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https://www.readbyqxmd.com/read/28081324/treatment-efficacy-and-superinfection-rates-in-complicated-urinarytract-infections-treated-with-ertapenem-or-piperacillin-tazobactam
#1
Murat Dizbay, Hasan Selçuk Özger, Ömer Karaşahin, Emine Fusun Karaşahin
BACKGROUND/AIM: In this retrospective study, the efficacy of ertapenem and piperacillin tazobactam was compared in the treatment of complicated urinary tract infections (cUTIs). Treatment responses were also evaluated for both antibiotics. MATERIALS AND METHODS: A total of 230 patients were enrolled in the study. Of these, 170 received ertapenem and 60 received piperacillin-tazobactam. RESULTS: In both groups, urine cultures after 48 h were negative for the initial uropathogen...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28069648/the-acinetobacter-outer-membrane-contains-multiple-specific-channels-for-carbapenem-%C3%AE-lactams-as-revealed-by-kinetic-characterization-analyses-of-imipenem-permeation-into-acinetobacter-baylyi-cells
#2
Jorgelina Morán-Barrio, María M Cameranesi, Verónica Relling, Adriana S Limansky, Luciano Brambilla, Alejandro M Viale
The number and type of outer membrane (OM) channels responsible of carbapenem uptake in Acinetobacter are still not well defined. Here, we addressed these questions using Acinetobacter baylyi as a model species and a combination of methodologies aimed to characterize OM channels in their original membrane environment. Kinetic and competition analyses of imipenem (IPM) uptake by A. baylyi whole cells allowed us to identify different carbapenem-specific OM uptake sites. Comparative analyses of IPM uptake by A...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28069335/-ertapenem-induced-neurological-toxicity-in-a-patient-with-stage-iv-chronic-kidney-disease
#3
Tomas Almorza, Marina Muñoz-Hernández, Antonio Lalueza
No abstract text is available yet for this article.
January 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28053586/comparison-of-phenotypic-and-pcr-methods-for-detection-of-carbapenemases-production-by-enterobacteriaceae
#4
Maryam AlTamimi, Ali AlSalamah, Manal AlKhulaifi, Hisham AlAjlan
Dissemination of carbapenem resistance via Enterobacteriaceae, particularly among Klebsiella pneumoniae and Escherichia coli, is a major public health concern. Rapid methods for determining antimicrobial susceptibility are important to ensure adequate and appropriate use of antimicrobial agents and to limit the spread of these bacteria. In the current study, we compared the rapidity, sensitivity and specificity of traditional methods and molecular-based Xpert Carba-R PCR assay to identify sixty isolates, (26 E...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28051952/antimicrobial-susceptibility-of-gram-negative-eskape-pathogens-isolated-from-hospitalized-patients-with-intra-abdominal-and-urinary-tract-infections-in-asia-pacific-countries-smart-2013-2015
#5
James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle Lob, Daniel F Sahm
Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are responsible for increases in antimicrobial-resistant infections worldwide. We determined in vitro susceptibilities to eight parenteral antimicrobial agents using CLSI broth microdilution methodology for gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal infections (IAI) (n = 3,052) and urinary tract infections (UTI) (n = 1,088) in 11 countries/regions from 2013-2015...
January 3, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28007722/physical-compatibility-of-isavuconazonium-sulfate-with-select-i-v-drugs-during-simulated-y-site-administration
#6
Wonhee So, Liz Kim, Abrar K Thabit, David P Nicolau, Joseph L Kuti
PURPOSE: The physical compatibility of isavuconazonium sulfate with 95 i.v. drugs during simulated Y-site administration was studied. METHODS: Isavuconazonium sulfate for injection and all other drugs were reconstituted according to the manufacturer's recommendation and further diluted with 0.9% sodium chloride injection or 5% dextrose injection to a final concentration (1.5 mg/mL for isavuconazonium sulfate and standard concentrations used clinically for other drugs)...
January 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27974169/antibiotics-first-versus-surgery-for-appendicitis-a%C3%A2-us-pilot-randomized-controlled-trial-allowing-outpatient-antibiotic-management
#7
David A Talan, Darin J Saltzman, William R Mower, Anusha Krishnadasan, Cecilia M Jude, Ricky Amii, Daniel A DeUgarte, James X Wu, Kavitha Pathmarajah, Ashkan Morim, Gregory J Moran
STUDY OBJECTIVE: Randomized trials suggest that nonoperative treatment of uncomplicated appendicitis with antibiotics-first is safe. No trial has evaluated outpatient treatment and no US randomized trial has been conducted, to our knowledge. This pilot study assessed feasibility of a multicenter US study comparing antibiotics-first, including outpatient management, with appendectomy. METHODS: Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole...
December 11, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27890667/investigation-of-carbapenem-resistance-and-the-first-identification-of-klebsiella-pneumoniae-carbapenemase-kpc-enzyme-among-escherichia-coli-isolates-in-turkey-a-prospective-study
#8
Mert Ahmet Kuskucu, Asiye Karakullukcu, Mailihaba Ailiken, Barıs Otlu, Bilgul Mete, Gokhan Aygun
BACKGROUND: The aim of this study was to determine the presence of carbapenem resistance and carbapenemase production in Escherichia coli isolates from clinical samples in Turkey. METHODS: The prospective study included a total of 4.052 Escherichia coli isolates collected from patients admitted to a hospital from March 2011 to May 2012. We used ertapenem disc for screening carbapenemase production, and the confirmation was performed by using Etest. The resistance mechanisms and genetic relatedness of the carbapenem resistant strains were investigated by using PCR (polymerase chain reaction) and pulsed-field gel electrophoresis (PFGE), respectively...
November 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27867083/trends-in-antimicrobial-resistance-among-bacteroides-species-and-parabacteroides-species-in-the-united-states-from-2010-2012-with-comparison-to-2008-2009
#9
REVIEW
D R Snydman, N V Jacobus, L A McDermott, E J C Goldstein, L Harrell, S G Jenkins, D Newton, R Patel, D W Hecht
The susceptibility trends for Bacteroides fragilis and related species against various antibiotics were determined using data from 3 years of surveillance (2010-2012) on 779 isolates referred by 7 medical centers. The antibiotic test panel included imipenem, ertapenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefoxitin, clindamycin, moxifloxacin, tigecycline, linezolid, chloramphenicol and . MICs were determined using the agar dilution CLSI reference method. Carbapenem resistance remained low (range 1...
November 17, 2016: Anaerobe
https://www.readbyqxmd.com/read/27866753/-molecular-epidemiology-of-carbapenemase-producing-enterobacteriaceae-infection-colonisation-in-a-hospital-in-madrid
#10
Patricia Brañas, Marta Gil, Jennifer Villa, María Ángeles Orellana, Fernando Chaves
INTRODUCTION: A description is presented on the molecular epidemiology of carbapenemase-producing enterobacteriaceae infection in a tertiary hospital. MATERIAL AND METHODS: A study was made on all the carbapenemase-producing enterobacteriaceae isolations obtained between February 2015 and March 2016 in the Hospital Universitario 12 de Octubre (Madrid). Phenotypic and molecular methods were used. RESULTS: A total of 7 bacterial species were identified, with the majority being Klebsiella pneumoniae (K...
November 17, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27851857/assessing-the-efficacy-and-safety-of-eravacycline-vs-ertapenem-in-complicated-intra-abdominal-infections-in-the-investigating-gram-negative-infections-treated-with-eravacycline-ignite-1-trial-a-randomized-clinical-trial
#11
Joseph Solomkin, David Evans, Algirdas Slepavicius, Patrick Lee, Andrew Marsh, Larry Tsai, Joyce A Sutcliffe, Patrick Horn
Importance: Eravacycline is a novel, fully synthetic fluorocycline antibiotic of the tetracycline class with in vitro activity against clinically important gram-negative, gram-positive aerobic, and facultative bacteria including most of those resistant to cephalosporins, fluoroquinolones, β-lactam/β-lactamase inhibitors, multidrug resistant strains and carbapenem-resistant Enterobacteriaceae, and most anaerobic pathogens. Objective: To evaluate the efficacy and safety of eravacycline compared with ertapenem in adult hospitalized patients with complicated intra-abdominal infections (cIAIs)...
November 16, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27836633/evaluation-of-automated-time-lapse-microscopy-for-assessment-of-in-vitro-activity-of-antibiotics
#12
Wanchana Ungphakorn, Christer Malmberg, Pernilla Lagerbäck, Otto Cars, Elisabet I Nielsen, Thomas Tängdén
This study aimed to evaluate the potential of a new time-lapse microscopy based method (oCelloScope) to efficiently assess the in vitro antibacterial effects of antibiotics. Two E. coli and one P. aeruginosa strain were exposed to ciprofloxacin, colistin, ertapenem and meropenem in 24-h experiments. Background corrected absorption (BCA) derived from the oCelloScope was used to detect bacterial growth. The data obtained with the oCelloScope were compared with those of the automated Bioscreen C method and standard time-kill experiments and a good agreement in results was observed during 6-24h of experiments...
January 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27802107/clonal-spread-of-colistin-resistant-klebsiella-pneumoniae-coproducing-kpc-and-vim-carbapenemases-in-neonates-at-a-tunisian-university-hospital
#13
Hajer Battikh, Chiraz Harchay, Amal Dekhili, Khaoula Khazar, Fehima Kechrid, Meriem Zribi, Afef Masmoudi, Chedlia Fendri
In this study, we have attempted to report the first clonal spread of colistin-resistant Klebsiella pneumoniae coproducing KPC and VIM carbapenemases in the neonatal unit of Rabta Teaching Hospital of Tunis (Tunisia). This retrospective study was performed from January 1, 2014 to December 31, 2014 in the Microbiology Laboratory at the Rabta University Hospital of Tunis. Twenty-one nonreplicate colistin-resistant K. pneumoniae were isolated from 19 patients hospitalized in the neonatal unit and 2 patients in the adult intensive care unit (ICU)...
November 1, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27795367/population-pharmacokinetics-and-target-attainment-of-ertapenem-in-plasma-and-tissue-assessed-via-microdialysis-in-morbidly-obese-patients-after-laparoscopic-visceral-surgery
#14
Mathias Wittau, Stephan Paschke, Max Kurlbaum, Jan Scheele, Neang S Ly, Evelyn Hemper, Marko Kornmann, Doris Henne-Bruns, Jürgen B Bulitta
Ertapenem provides broad-spectrum activity against many pathogens, and its use is relevant for the prophylaxis and treatment of infections in morbidly obese patients undergoing surgery. However, its pharmacokinetics and tissue penetration in these patients are not well defined. We assessed the population pharmacokinetics and target attainment for ertapenem in the plasma, subcutaneous tissue, and peritoneal fluid of morbidly obese patients. Six female patients (body mass index, 43.7 to 55.9 kg/m(2)) received 1,000 mg ertapenem as 15-min infusions at 0 and 26 h...
January 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27788691/outbreak-of-kpc-3-producing-st15-and-st348-klebsiella-pneumoniae-in-a-portuguese-hospital
#15
D Vubil, R Figueiredo, T Reis, C Canha, L Boaventura, G J DA Silva
To date, only a few sporadic cases of infections due to Klebsiella pneumoniae carbapenemase (KPC) producers have been reported in Portugal. Here, we report for the first time an outbreak of K. pneumoniae KPC-3 producers in a tertiary-care hospital during 2013. Twenty-seven ertapenem-resistant K. pneumoniae were identified in patients at a tertiary-care hospital during 2013 isolated predominantly from urine (48·1%) and blood (25·9%) cultures. All isolates were highly resistant to β-lactam antibiotics and most showed intermediate resistance to imipenem...
October 28, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27773498/comparative-pharmacodynamics-of-four-different-carbapenems-in-combination-with-polymyxin-b-against-carbapenem-resistant-acinetobacter-baumannii
#16
Justin R Lenhard, Jonathan S Gall, Jurgen B Bulitta, Visanu Thamlikitkul, Cornelia B Landersdorfer, Alan Forrest, Roger L Nation, Jian Li, Brian T Tsuji
The objective of this study was to determine the comparative pharmacodynamics of four different carbapenems in combination with polymyxin B (PMB) against carbapenem-resistant Acinetobacter baumannii isolates using time-kill experiments at two different inocula. Two A. baumannii strains (03-149-1 and N16870) with carbapenem minimum inhibitory concentrations (MICs) ranging from 8 to 64 mg/L were investigated in 48-h time-kill experiments using starting inocula of 10(6) CFU/mL and 10(8) CFU/mL. Concentration arrays of ertapenem, doripenem, meropenem and imipenem at 0...
December 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27754776/first-description-of-kpc-2-producing-escherichia-coli-and-st15-oxa-48-positive-klebsiella-pneumoniae-in-tunisia
#17
Farah Ben Tanfous, Carla Andrea Alonso, Wafa Achour, Laura Ruiz-Ripa, Carmen Torres, Assia Ben Hassen
The aim of this study was to investigate the molecular features among Klebsiella pneumoniae and Escherichia coli strains showing a resistant/intermediate-resistant phenotype to ertapenem (R/IR-ERT), implicated in colonization/infection in patients of the Hematology and Graft Units of the National Bone Marrow Transplant Center of Tunisia (3-year period, 2011-2014). The major carbapenemase, extended-spectrum beta-lactamase, and plasmidic AmpC beta-lactamase genes were analyzed and characterized by PCR and sequencing...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27747899/safety-and-efficacy-of-outpatient-parenteral-antibiotic-therapy-in-an-academic-infectious-disease-clinic
#18
G Suleyman, R Kenney, M J Zervos, A Weinmann
WHAT IS KNOWN AND OBJECTIVE: Outpatient parenteral therapy (OPAT) has become a safe and effective modality for patients requiring intravenous or prolonged antimicrobial therapy since the 1970s. It is being increasingly utilized in various settings; however, studies evaluating the safety and efficacy of clinic-based OPAT are limited. Since 2012, patients being considered for OPAT have required an infectious disease (ID) consultation at our institution. Candidates receiving once-daily antimicrobials who were ineligible for home infusion or nursing home placement as determined by their insurance companies and those who preferred the clinic over nursing home or home infusion were referred to the ID clinic...
February 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27747731/status-epilepticus-and-delirium-associated-with-ertapenem-in-a-very-elderly-patient-with-chronic-kidney-disease-and-silent-ischaemic-cerebrovascular-disease
#19
Huimin Lin, Samuel T H Chew
An 85-year-old female with chronic kidney disease and newly acquired seizures on oral phenytoin received intravenous ertapenem 500 mg once daily for a urinary tract infection and bacteraemia involving extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. After three ertapenem doses, she developed seizures which self-aborted. Corrected phenytoin level was sub-therapeutic initially, but became therapeutic following a phenytoin dose increase. On Day 14 of ertapenem, the patient suffered another episode of seizure...
December 2015: Drug Saf Case Rep
https://www.readbyqxmd.com/read/27736757/effect-of-high-n-acetylcysteine-concentrations-on-antibiotic-activity-against-a-large-collection-of-respiratory-pathogens
#20
Giulia Landini, Tiziana Di Maggio, Francesco Sergio, Jean-Denis Docquier, Gian Maria Rossolini, Lucia Pallecchi
The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity...
December 2016: Antimicrobial Agents and Chemotherapy
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