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G Suleyman, R Kenney, M J Zervos, A Weinmann
WHAT IS KNOWN AND OBJECTIVE: Outpatient parenteral therapy (OPAT) has become a safe and effective modality for patients requiring intravenous or prolonged antimicrobial therapy since the 1970s. It is being increasingly utilized in various settings; however, studies evaluating the safety and efficacy of clinic-based OPAT are limited. Since 2012, patients being considered for OPAT have required an infectious disease (ID) consultation at our institution. Candidates receiving once-daily antimicrobials who were ineligible for home infusion or nursing home placement as determined by their insurance companies and those who preferred the clinic over nursing home or home infusion were referred to the ID clinic...
October 16, 2016: Journal of Clinical Pharmacy and Therapeutics
Huimin Lin, Samuel T H Chew
An 85-year-old female with chronic kidney disease and newly acquired seizures on oral phenytoin received intravenous ertapenem 500 mg once daily for a urinary tract infection and bacteraemia involving extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. After three ertapenem doses, she developed seizures which self-aborted. Corrected phenytoin level was sub-therapeutic initially, but became therapeutic following a phenytoin dose increase. On Day 14 of ertapenem, the patient suffered another episode of seizure...
December 2015: Drug Saf Case Rep
Giulia Landini, Tiziana Di Maggio, Francesco Sergio, Jean-Denis Docquier, Gian Maria Rossolini, Lucia Pallecchi
The effect of high NAC concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised carbapenem activity (mostly imipenem and, to a lesser extent, meropenem and ertapenem) in a dose-dependent fashion. Chemical instability of carbapenems in the presence of NAC was demonstrated. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity...
October 10, 2016: Antimicrobial Agents and Chemotherapy
Nitin Rathod, Pavan Pai
We present a case of 58 years old male patient, who presented with high fever for which injection Ertapenem was started empirically at Dubai hospital. Patient was a known case of Deep vein thrombosis of left leg since 5 years on warfarin therapy. Patient came to India for high fever and further management. Patient developed proteinuria with high creatinine and urinary abnormalities. Renal biopsy revealed acute interstitial nephritis (AIN). In addition, he was diagnosed to have protein S deficiency with Factor V Leiden mutation...
March 2016: Journal of the Association of Physicians of India
O Perovic, E Britz, V Chetty, A Singh-Moodley
Molecular confirmation of carbapenemase-producing Enterobacteriaceae (CPE) was introduced in South Africa (SA) at the end of 2011. We report on the detection of these resistance genes based on referral isolates. Enterobacteriaceae with non-susceptibility to any of the carbapenems according to defined criteria for antimicrobial susceptibility testing results were sent to a reference laboratory. A proportion of isolates had limited demographic, epidemiological and clinical data available. Organism identification was reconfirmed using reference laboratory methods, and the presence of carbapenemases was confirmed with a real-time polymerase chain reaction...
September 6, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Ashika Singh-Moodley, Olga Perovic
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) is a concern in South Africa and worldwide. It is therefore important that these organisms be accurately identified for infection prevention control purposes. METHOD: In this study 1193 suspected CREs from 46 laboratories from seven provinces in South Africa were assessed to confirm the prevalence of carbapenemase genes from our referral diagnostic isolates for the period 2012 to 2015. We compared the antimicrobial susceptibility testing method used in the reference laboratory to the polymerase chain reaction (PCR) which is used as the gold standard...
October 4, 2016: BMC Infectious Diseases
Shio-Shin Jean, Po-Ren Hsueh
OBJECTIVES: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intra-abdominal infections (IAIs) in patients hospitalized in the Asia-Pacific region during 2008-14. METHODS: Multiplex PCR was used to detect the specific types of β-lactamase in 2893 isolates with MICs of ertapenem >0.5 mg/L. In-hospital acquisition times for most isolates were also delineated...
October 4, 2016: Journal of Antimicrobial Chemotherapy
Meklit Workneh, Frances Wang, Mark Romagnoli, Patricia J Simner, Karen Carroll
We report a case of bypass graft infection and bacteremia caused by Anaerostipes caccae. A review of the literature shows no reported human infection caused by this microorganism to date. The patient was initially treated with vancomycin and piperacillin-tazobactam on admission and with amoxicillin-clavulanate upon discharge. The slow-growing organism was subsequently found to be susceptible to metronidazole and ertapenem.
September 28, 2016: Anaerobe
Mark A Baker, Elena K Schneider, Johnny X Huang, Matthew A Cooper, Jian Li, Tony Velkov
Ertapenem is an important first-line carbapenem antibiotic used for the treatment of aerobic Gram-negative bacterial infections. It is the only carbapenem that is highly bound to plasma proteins and displays a concentration-dependent and saturable plasma protein binding profile. To date the plasma components responsible for sequestering ertapenems antibacterial activity remain uncharacterised. In the present study we have employed an orthogonal, multi-platform approach, including novel compound-centric displacement proteomics and Surface Plasmon Resonance to characterise the plasma protein binding proteome of ertapenem...
September 28, 2016: ACS Chemical Biology
Manuel Kussmann, Linda Schuster, Sarah Wrenger, Petra Pichler, Gottfried Reznicek, Heinz Burgmann, Wolfgang Poeppl, Markus Zeitlinger, Martin Wiesholzer
♦ Background: Peritonitis is a major problem among patients on peritoneal dialysis (PD). The influence of diverse PD fluids on the activity of frequently used antibiotics has been insufficiently investigated. Thus, the present study set out to investigate the impact of different PD fluids on the activity of cefepime, ciprofloxacin, ertapenem, meropenem, and tobramycin against Escherichia coli. ♦ Methods: Time-kill curves in 4 different PD fluids (Dianeal PDG4, Extraneal, Nutrineal PD4 and Physioneal 40, all Baxter Healthcare Corp...
September 28, 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Baharak Babouee Flury, Matthew J Ellington, Katie L Hopkins, Jane F Turton, Michel Doumith, Neil Woodford
Mechanisms leading to carbapenem and cephalosporin resistance were sought in Enterobacter aerogenes isolates that were highly resistant to carbapenems but had no known carbapenemase. Results were compared with recent work examining carbapenem-resistant Enterobacter cloacae. Eighteen carbapenem-resistant E. aerogenes were screened for known β-lactamase and carbapenemase genes, and novel carbapenemases were sought in whole-genome sequencing (WGS) data of the three most resistant isolates. For all isolates, ampC, ampR, ampD and the porin genes omp35 and omp36 were investigated by Sanger sequencing or from available WGS data...
September 12, 2016: International Journal of Antimicrobial Agents
Lotfi Loucif, Ahmed Kassah Laouar, Mahdia Saidi, Amina Messala, Widad Chelaghma, Jean-Marc Rolain
Seven non-redundant ertapenem-resistant Klebsiella pneumoniae isolates were collected from May 2014 to January 19, 2015 in the nephrology and hematology units of Batna University Hospital, Algeria. All strains coproduced the blaOXA-48, blaCTX-M-15, blaSHV-1 and blaTEM-1D genes. Six of these isolates belonged to the pandemic clone ST101. The blaOXA-48 gene was located on a conjugative IncL/M-type plasmid. This is the first outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital, Algeria...
September 19, 2016: Antimicrobial Agents and Chemotherapy
Sandra Liliana Valderrama, Pedro Felipe González, María Alejandra Caro, Natalia Ardila, Beatriz Ariza, Fabián Gil, Carlos Álvarez
INTRODUCTION: Bacteremia due to Pseudomonas aeruginosa resistant to carbapenems is a public health problem due to the limitations it places on therapeutic options, as well as the increased time patients must spend in hospital, costs and the risk of mortality.  OBJECTIVE: To evaluate the risk factors for presentation of bacteremia due to carbapenem-resistant P. aeruginosa acquired in the Hospital Universitario San Ignacio between January 2008 and June 2014.  MATERIALS AND METHODS: This was a case control study in which the case patients presented bacteremia due to P...
2016: Biomédica: Revista del Instituto Nacional de Salud
Claire Roubaud-Baudron, Emmanuel Forestier, Thibaut Fraisse, Jacques Gaillat, Benoit de Wazières, Leonardo Pagani, Isabelle Ingrand, Louis Bernard, Gaëtan Gavazzi, Marc Paccalin
BACKGROUND/OBJECTIVE: although poorly documented, subcutaneous (SC) administration of antibiotics is common practice in France especially in Geriatrics Departments. The aim of this study was to determine the tolerance of such a practice. DESIGN: prospective observational multicentre study. METHODS: sixty-six physicians accepted to participate from 50 French Infectious Diseases and Geriatrics Departments. From May to September 2014, patients treated at least one day with SC antibiotics could be included...
September 8, 2016: Age and Ageing
D Sousa, J M Bravo-Ferrer, T Seoane-Pillado, P Vázquez-Rodríguez, L Ramos-Merino, J M Gutiérrez-Urbón, S Pita, P Llinares
OBJECTIVE: The clinical response to ertapenem in community-acquired pneumonia (CAP) at the setting of routine hospital practice has been scarcely evaluated. METHODS: We retrospectively compared CAP cases treated with ertapenem or with other standard antimicrobials (controls) at a tertiary 1,434-bed center from 2005 to 2014. RESULTS: Out of 6,145 patients hospitalized with CAP, 64 (1%) ertapenem-treated and 128 controls were studied (PSI IV-V 72%, mean age 73 years...
October 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Marta Vallejo, Diana P Cuesta, Luz E Flórez, Adriana Correa, Carmen E Llanos, Berenice Isaza, Stella Vanegas, Johanna Osorio, Lucía Casanova, María V Villegas
INTRODUCTION: Complicated community-acquired intra-abdominal infections (CA-cIAI) are a common cause of acute abdomen. OBJECTIVE: To identify the clinical and microbiology profile of CA-cIAI in four Colombian hospitals. METHODS: This is a prospective, descriptive study, between 08-2012 and 09-2014, including patients with CA-cIAI > 15 years. Data collected included: socio-demographic, clinical, diagnosis, and isolates of the first culture obtained aseptically during surgery with antimicrobial susceptibility...
June 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Tahisa M Pedroso, Ana C D Medeiros, Herida R N Salgado
Ertapenem sodium is a polar and ionizable compound; therefore, it has little retention on traditional C18 columns in reverse-phase high-performance liquid chromatography, even using a highly-aqueous mobile phase that can result in dewetting in the stationary phase. Thus, the most coherent process for ERTM is to develop a method for Hydrophilic Interaction Chromatography. However, for the traditional methods in HILIC, the use of a highly organic mobile phase is necessary; usually an amount exceeding 80% acetonitrile is necessary...
November 1, 2016: Talanta
Seok Hoon Jeong, Han Sung Kim, Jae Seok Kim, Dong Hoon Shin, Hyun Soo Kim, Min Jeong Park, Saeam Shin, Jun Sung Hong, Seung Soon Lee, Wonkeun Song
BACKGROUND: The emergence of carbapenemase-producing Enterobacteriaceae (CPE) represents a major clinical problem because these bacteria are resistant to most antibiotics. CPE remain relatively uncommon in Korea. We report the prevalence, clinical characteristics, and molecular epidemiology of CPE isolates collected from five university hospitals in Korea. METHODS: Between January and December 2015, 393 non-duplicated isolates that were nonsusceptible to ertapenem were analyzed...
November 2016: Annals of Laboratory Medicine
Kassu Desta, Yimtubezinash Woldeamanuel, Aklilu Azazh, Halima Mohammod, Dawit Desalegn, Damte Shimelis, Dereje Gulilat, Biruk Lamisso, Eyasu Makonnen, Alemayehu Worku, Kerstin Mannerqvist, Johan Struwe, Olov Aspevall, Eleni Aklillu
We investigated the gastrointestinal colonization rate and antibiotic resistance patterns of Extended-Spectrum Beta-Lactamase (ESBL)- producing Escherichia coli and Klebsiella pneumoniae in hospitalized patients admitted at Ethiopia's largest tertiary hospital. Fecal samples/swabs from 267 patients were cultured on chrome agar. ESBL. Bacterial species identification, verification of ESBL production and antibiotic susceptibility testing were done using Vitek 2 system (bioMérieux, France). Phenotype characterization of ESBL-E...
2016: PloS One
George Sakoulas, Joshua Olson, Juwon Yim, Niedita B Singh, Monika Kumaraswamy, Diana T Quach, Michael J Rybak, Joseph Pogliano, Victor Nizet
BACKGROUND: Ertapenem and cefazolin were used in combination to successfully clear refractory methicillin-susceptible Staphylcoccus aureus (MSSA) bacteremia. In addition, recent work has demonstrated acitivity of combination beta-lactam therapy from different classes against MRSA. METHODS: Ertapenem plus cefazolin combination was evaluated for synergy in vitro and in vivo in a murine skin infection model using an index MSSA bloodstream isolate from a patient in whom persistent bacteremia was cleared with this combination, and against a cadre of well-described research strains and clinical strains of MSSA and MRSA...
August 29, 2016: Antimicrobial Agents and Chemotherapy
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