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Ertapenem

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https://www.readbyqxmd.com/read/28815094/add-on-therapy-with-ertapenem-in-infections-with-multidrug-resistant-gram-negative-bacteria-pediatric-experience
#1
Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Kamile Oktay Arıkan, Ayse Buyukcam, Ali Bulent Cengiz, Mehmet Ceyhan, Ates Kara
Optimal therapy for infections with carbapenem resistant GNB is not well established due to the weakness of data. Patients presenting with bloodstream infections caused by multidrug resistant Klebsiella pneumoniae were treated with a combination treatment. Optimal therapy for infections with carbapenem resistant Gram-negative bacteria is a serious problem in pediatric patients. We presented three cases who were successfully treated with addition of ertapenem to the combination treatment for bacteremia with multidrug resistant Klebsiella pneumoniae...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28799835/occurrence-of-carbapenemase-producing-enterobacteriaceae-isolates-in-the-wildlife-first-report-of-oxa-48-in-wild-boars-in-algeria
#2
Taous Bachiri, Sofiane Bakour, Rym Lalaoui, Nadia Belkebla, Meriem Allouache, Jean Marc Rolain, Abdelaziz Touati
The aim of the present study was to screen for the presence of carbapenemase-producing Enterobacteriaceae (CPE) isolates from wild boars and Barbary macaques in Algeria. Fecal samples were collected from wild boars (n = 168) and Barbary macaques (n = 212), in Bejaia, Algeria, between September 2014 and April 2016. The isolates were identified and antimicrobial susceptibility was determined. Carbapenem resistance determinants were studied using PCR and sequencing, while clonal relatedness was performed using multilocus sequence typing (MLST)...
August 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28792697/the-first-enterobacter-cloacae-co-producing-ndm-and-oxa-48-carbapenemases-and-interhospital-spread-of-oxa-48-and-ndm-producing-klebsiella-pneumoniae-in-turkey
#3
Demet Haciseyitoglu, Aysegul Dokutan, Ayham Abulaila, Fatma Erdem, Yasemin Cag, Serdar Ozer, Zerrin Aktas
BACKGROUND: The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae. METHODS: A total of 54 carbapenem nonsusceptible Enterobacteriaceae (CRE) isolates were recovered from clinical samples sent to the Dr. Lutfi Kirdar Kartal Training and Research Hospital from the period 2011 through 2014. Forty-four isolates were Klebsiella pneumoniae (CRKP) and the other 10 were Enterobacter cloacae (CREC).The isolate identifications and antibiotic sensitivity tests were performed using a Vitek2 automatic system...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28767588/successful-ceftazidime-avibactam-treatment-of-mdr-kpc-positive-klebsiella-pneumoniae-infection-in-a-patient-with-traumatic-brain-injury-a-case-report
#4
Agnese Gugliandolo, Carla Caio, Maria Lina Mezzatesta, Carmela Rifici, Placido Bramanti, Stefania Stefani, Emanuela Mazzon
RATIONALE: Carbapenem-resistant Enterobacteriaceae infections are a serious health care problem, because of the high mortality. Carbapenem resistance is mainly caused by carbapenemases production, including Klebsiella pneumoniae carbapenemase (KPC). Ceftazidime-avibactam is a new cephalosporin/β-lactamase inhibitor combination for the treatment of complicated urinary, intra-abdominal infections, and nosocomial pneumonia caused by gram negative, or other serious gram-negative infections...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28759588/risk-factors-associated-with-the-development-of-seizures-among-adult-patients-treated-with-ertapenem-a-matched-case-control-study
#5
Yi-Chien Lee, Yun-Jhong Huang, Miao-Chiu Hung, Sheng-Che Hung, Chih-Yen Hsiao, Hui-Ling Cho, Li-Fen Lai, Show-Hwa Tong, Jann-Tay Wang
OBJECTIVE: The purpose of this study is to compare the characteristics of those ertapenem-treated adult patients with and without development of seizures, and identify the associated factors for the development of seizures. METHODS: This retrospective study was conducted at Chia-Yi Christian Hospital from January 2012 to December 2014. Patients developing seizures during their ertapenem treatment course were identified as case patients. Those without seizures who had received ertapenem for at least five days were considered as the pool of control patients...
2017: PloS One
https://www.readbyqxmd.com/read/28755095/neurological-adverse-effects-attributable-to-%C3%AE-lactam-antibiotics-a-literature-review
#6
REVIEW
Samuel Deshayes, Antoine Coquerel, Renaud Verdon
β-lactam antibiotics are commonly prescribed antibiotic drugs. To describe the clinical characteristics, risk markers and outcomes of β-lactam antibiotic-induced neurological adverse effects, we performed a general literature review to provide updated clinical data about the most used β-lactam antibiotics. For selected drugs in each class available in France (ticarcillin, piperacillin, temocillin, ceftazidime, cefepime, cefpirome, ceftaroline, ceftobiprole, ceftolozane, ertapenem and aztreonam), a systematic literature review was performed up to April 2016 via an electronic search on PubMed...
July 28, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28737463/prevalence-of-a-new-variant-oxa-204-and-oxa-48-carbapenemases-plasmids-encoded-in-klebsiella-pneumoniae-clinical-isolates-in-tunisia
#7
Rym Ouertani, Mariem Ben Jomàa-Jemili, Haythem Gharsa, Anne Limelette, Thomas Guillard, Lucien Brasme, Christophe de Champs, Chedly Chouchani
Carbapenemase-producing Klebsiella pneumoniae strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the role and diversity of plasmids harboring carbapenemases encoding genes from a collection of K. pneumoniae isolates recovered between July 2011 and January 2012, with decreased susceptibility to carbapenems. Imipenem (IPM), ertapenem (ETP), meropenem (MEM), and doripenem (DOR) minimum inhibitory concentrations (MICs) were determined by E-test. Carbapenemase production was detected with the modified Hodge test...
July 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28717993/probing-the-binding-affinities-of-imipenem-and-ertapenem-for-outer-membrane-carboxylate-channel-d1-occd1-from-p-aeruginosa-simulation-studies
#8
Kamolrat Somboon, Jitti Niramitranon, Prapasiri Pongprayoon
Pseudomonas aeruginosa is an important nosocomial human pathogen. The major difficulty in the fight against this pathogen is the relative impermeability of its outer membrane (OM). Only specific substrates can penetrate through the OM of P. aeruginosa via substrate-specific porins, so this has become one of the most problematic drug-resistant pathogens. Carbapenems are the most effective drugs for treating P. aeruginosa infections. One such carbapenem that is applied in cases of P. aeruginosa infection is imipenem (IMI), which uses outer membrane carboxylate channel D1 (OccD1) as a point of entry into the pathogen...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28711560/interaction-of-carbapenems-and-%C3%AE-lactamase-inhibitors-towards-ctx-m-15-and-ctx-m-15-g238c-mutant
#9
Alessia Sabatini, Fabrizia Brisdelli, Giuseppe Celenza, Francesca Marcoccia, Martina Colapietro, María M Tavío, Alessandra Piccirilli, Gianfranco Amicosante, Mariagrazia Perilli
OBJECTIVES: The aim of this study was to evaluate the role of residue 238 in CTX-M-15 and CTX-M-15(G238C) mutant with respect to carbapenems and various β-lactamase inhibitors. METHODS: A CTX-M-15(G238C) laboratory mutant was generated by site-directed mutagenesis from CTX-M-15 enzyme by replacing glycine 238 with cysteine. Thiol titration and p-chloromercuribenzoate (PCMB) inactivation assays were used to ascertain the presence of a disulfide bridge in the active site of CTX-M-15(G238C)...
July 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28708458/effectiveness-of-a-double-carbapenem-regimen-in-a-kpc-producing-klebsiella-pneumoniae-infection-in-an-immunocompromised-patient
#10
Nuria Piedra-Carrasco, Lucia Miguel, Anna Fàbrega, Belén Viñado, David Campany, Alba Mir, María Laura Fox, Benito Almirante, Nieves Larrosa, Isabel Ruiz-Camps, Juan José González-López
The progressive increase of infections produced by extensively drug-resistant carbapenemase-producing Klebsiella pneumoniae (XDR-CPKP) represents an important threat to public health. Unfortunately, optimal therapeutic options are scarce. Retrospective studies have recommended combined therapy with more than one antibiotic and, more recently, a double-carbapenem regimen has been reported to be an effective alternative therapy. Here, we describe an episode of sepsis in an immunocompromised patient after allogeneic hematopoietic stem cell transplantation, caused by an XDR-CPKP...
July 14, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28705799/rapid-developing-empyema-by-group-f-beta-streptococcus-anginosus-group
#11
Muhammad Azharuddin, Dy Prudence, Prem Shanker Shukla, Ajay Mathur
A 43-year-old male had progressive pleuritic left-sided chest tightness with shortness of breath. He had dental caries and tenderness on palpation of the left lateral chest. Complete blood count showed leucocytosis. CT scan of the chest with pulmonary emboli protocol showed multiple pulmonary nodules and nodular pleural thickening at left posterior lateral pleura. Forty-eight hours post CTPE scan, CT scan of the chest, abdomen and pelvis displayed right lower lobe consolidation and left-sided pleural effusion with superimposed compressive atelectasis...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28700141/zero-and-second-derivative-synchronous-fluorescence-spectroscopy-for-the-quantification-of-two-non-classical-%C3%AE-lactams-in-pharmaceutical-vials-application-to-stability-studies
#12
Eman S Elzanfaly, Rania M Youssif, Nahla N Salama, Ahmed S Fayed, Hassan A M Hendawy, Maissa Y Salem
The formation of metal chelates with various ligands may lead to the production of fluorescent chelates or enhance the fluorescence of the chelating agent. This paper describes two sensitive, selective and computer-solved methods, namely, zero order (SF) and second-derivative synchronous spectrofluorimetry (SDSFS) for nano-quantitation of two carbapenems; meropenem (MP) and ertapenem (EP). The methods are based on the chelation of MP with Tb(3+) and EP with Zr(4+) in buffered organic medium at pH 4.0 to produce fluorescent chelates...
July 12, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28696238/the-sterilizing-effect-of-ertapenem-clavulanate-in-a-hollow-fiber-model-of-tuberculosis-and-implications-on-clinical-dosing
#13
Sander P van Rijn, Shashikant Srivastava, Mireille A Wessels, Dick van Soolingen, Jan-Willem C Alffenaar, Tawanda Gumbo
Carbapenems are now being explored for treatment of multi-drug resistant tuberculosis (MDR-TB), especially in conjunction with clavulanate. Clinical use is constrained by the need for multiple parenteral doses per day, and lack of knowledge of the optimal dose for sterilizing effect. Our objective was to identify the ertapenem exposure associated with optimal sterilizing effect and then design a once a day dose for clinical use. We utilized the hollow fiber system model of tuberculosis in a 28-day exposure-response study of 8 different ertapenem doses in combination with clavulanate...
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28693929/impact-of-broad-spectrum-antimicrobial-treatment-on-the-ecology-of-intestinal-flora
#14
Jen-Jia Yang, Jann-Tay Wang, Aristine Cheng, Yu-Chung Chuang, Wang-Huei Sheng
BACKGROUND: Suppression of intestinal flora by broad-spectrum antimicrobial agents facilitated risk of colonization or infection with resistant pathogen. We aimed to investigate the changes in bowel carriage of target resistant microorganisms (TRO) among patients treated with three different classes of Pseudomonas-sparing broad-spectrum antimicrobial agents (ertapenem, moxifloxacin and flomoxef) with anaerobic coverage. Risk factors for developing colonization of TRO were also analyzed...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28687555/visual-compatibility-of-colistin-injection-with-other-antibiotics-during-simulated-y-site-administration
#15
Wasan Katip
PURPOSE: The compatibility of colistin with other antibiotics at concentrations commonly used in intensive care units was studied. METHODS: A vial of colistin was dissolved in sterile water for injection. The reconstituted solution (colistin base 75 mg/mL) was then diluted in 0.9% sodium chloride injection in polyvinyl chloride (PVC) infusion bag to give a total volume of 100 mL (colistin 1.5 mg/mL). Secondary drugs, including cefoperazone-sulbactam, ceftazidime, ertapenem, fosfomycin, imipenem-cilastatin, linezolid, meropenem, piperacillin-tazobactam, and vancomycin, were reconstituted if necessary and then diluted in 0...
July 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28679413/double-carbapenem-as-a-rescue-strategy-for-the-treatment-of-severe-carbapenemase-producing-klebsiella-pneumoniae-infections-a-two-center-matched-case-control-study
#16
Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane, Massimo Antonelli
BACKGROUND: Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate the clinical impact of such a regimen in critically ill patients. METHODS: This case-control (1:2), observational, two-center study involved critically ill adults with a microbiologically documented CR-Kp invasive infection treated with the DC regimen matched with those receiving a standard treatment (ST) (i...
July 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28676284/incx3-plasmid-mediated-occurrence-of-blandm-4-within-escherichia-coli-st448-from-india
#17
Nargis Alom Choudhury, Deepjyoti Paul, Atanu Chakravarty, Amitabha Bhattacharjee, Debadatta Dhar Chanda
This study was designed to investigate blaNDM-4 encoded within IncX3 type plasmid and their copy number alteration under carbapenem pressure within clinical isolates of Escherichia coli. NDM-4 producing E. coli isolates were collected from an Indian hospital and transferability as well as plasmid incompatibility typing was determined. Genetic environment and antibiogram profiling was carried out. Quantitative Real Time PCR was done to determine the change in plasmid copy number under concentration gradient carbapenem stress...
July 1, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28661313/acute-appendicitis-after-kidney-transplantation-experience-at-a-tertiary-care-hospital-in-mexico-city
#18
Edgar Ortiz-Brizuela, Alejandro Quiroz-Compeán, Mario Vilatobá-Chapa, Josefina Alberú-Gómez
OBJECTIVES: Here, we describe the presentation, treatment, and outcomes of acute appendicitis in kidney transplant recipients at a tertiary care hospital in Mexico City. MATERIALS AND METHODS: We conducted a retrospective case series study at a tertiary care hospital in Mexico City from January 2000 to January 2015. RESULTS: During our study period, 1186 patients received a kidney transplant; among these patients, we identified 10 cases of acute appendicitis (0...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28660131/successful-treatment-of-multidrug-resistant-klebsiella-pneumoniae-using-dual-carbapenem-regimen-in-immunocompromised-patient
#19
Wasim S El Nekidy, Mohamed Y Mooty, Nizar Attallah, Lyssette Cardona, Maria Fernanda Bonilla, Islam M Ghazi
This report describes a longitudinal case of immunocompromised patient post kidney transplant who was admitted to our institution repeatedly for treatment of various infections caused by multi-drug resistant Klebsiella pneumoniae. The patient was successfully treated with a combination of ertapenem/meropenem on multiple occasions despite the elevated MICs. Our observations corroborate previous preclinical studies and case reports showing the efficacy of double carbapenem regimens against resistant Enterobacteriaceae...
2017: IDCases
https://www.readbyqxmd.com/read/28652947/ertapenem-induced-thrombocytosis
#20
Ramon A Docobo, Sumera Bukhari, Zulfiqar Qutrio Baloch
Ertapenem is a β-lactam antibiotic that has a broad spectrum of anti-microbial coverage. Hematological adverse events like thrombocytosis, neutropenia, and neutropenia are infrequent. Here we report a rare case of drug-induced thrombocytosis in a 68-year-old female, who was treated with ertapenem for the diagnosis of complicated abdominal infection. This case emphasizes that any patient with thrombocytosis should be assessed with a careful and detailed history with consideration for possible drug side effects...
May 19, 2017: Curēus
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