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Ertapenem

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https://www.readbyqxmd.com/read/29316136/transrectal-prostate-biopsy-sepsis-rate-following-reduced-quinolone-antibiotic-prophylaxis-from-six-doses-to-single-dose
#1
Haider K Bangash, Cynthia Hawks, Steve P McCombie, Matthew Brown, Dickon Hayne
BACKGROUND: This study aimed to evaluate the rates of infective complication related to transrectal prostate biopsy (TRPB) as our centre changed its protocol from six doses over 3 days to a single pre-procedure prophylactic dose. METHODS: This prospective cohort study identified infective complication in patients who attended and subsequently underwent TRPB at the time of their one-stop prostate clinic at our public tertiary hospital between August 2011 and April 2017...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29309948/molecular-characterization-and-epidemiology-of-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolates-from-immunocompromised-patients-in-tunisia
#2
Farah Ben Tanfous, Wafa Achour, Anis Raddaoui, Assia Ben Hassen
OBJECTIVES: This study investigated the prevalence of extended-spectrum β-lactamase producing K. pneumoniae (ESBL-KP) strains in the National Bone Marrow Transplant Center of Tunis between 2002 and 2011, their associated antibiotics resistance patterns and their molecular features. METHODS: Antimicrobial susceptibility was determined by the disk diffusion method according to CA-SFM guidelines. All the strains were screened for beta-lactamase genes, plasmidic AmpC genes and integrons...
January 5, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29303686/microbiologic-analysis-of-complicated-and-uncomplicated-acute-appendicitis
#3
Andrés García-Marín, Mercedes Pérez-López, Elena Martínez-Guerrero, Lorena Rodríguez-Cazalla, Antonio Compañ-Rosique
BACKGROUND: Microbiologic studies suggest that complicated (CAA) and uncomplicated (UAA) acute appendicitis are different entities. Routine peritoneal fluid cultures continue to be controversially related to a low positive rate, found mainly in UAA; to isolation of typical micro-organisms with expected susceptibilities; and to a community-acquired intra-abdominal infection. The aim of this study was to describe microbiologic isolates in CAA and UAA and the usefulness of peritoneal fluid cultures to determine the susceptibilities to our antibiotic therapy guidelines...
January 2018: Surgical Infections
https://www.readbyqxmd.com/read/29303020/risk-factors-outcomes-and-genotypes-of-carbapenem-nonsusceptible-klebsiella-pneumoniae-bloodstream-infection-a-three-year-retrospective-study-in-a-large-tertiary-hospital-in-northern-china
#4
Si-Han Zheng, Sheng-Ji Cao, Hui Xu, Dan Feng, Li-Ping Wan, Guang-Jie Wang, Xiao-Guang Xiao
OBJECTIVE: To investigate the independent risk factors, outcomes and genotypes associated with carbapenem-non-susceptible K. pneumoniae bloodstream infections (BSIs) in northern China from 2014 to 2016. METHODS: Over a three-year period, a total of 289 K. pneumoniae BSI patients were identified. Medical records were extracted to obtain the clinical information. Polymerase chain reactions (PCRs) were performed to analyse the multilocus sequence typing (MLST) types, Klebsiella pneumoniae carbapenemase (KPC) and metallo-β-lactamases (MBL) genes, for replicon typing of the 10 randomly selected carbapenem-non-susceptible K...
January 5, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29275225/the-efflux-pump-inhibitor-phenylalanine-arginine-beta-naphthylamide-pa%C3%AE-n-increases-the-resistance-to-carbapenems-in-chilean-clinical-isolates-of-kpc-producing-k-pneumoniae
#5
Alejandra Vera-Leiva, Sergio Carrasco-Anabalón, Celia A Lima, Nicolás Villagra, Mariana Domínguez, Helia Bello-Toledo, Gerardo González-Rocha
OBJECTIVES: KPC-producing strains present a wide range of MICs of carbapenems; this variation may be due to different gene expression levels of the blaKPC and porin genes, associated with efflux-pumps and the production of ESBLs and/or AmpC β-lactamase. The aim of this study was to determine the role of efflux-pumps inhibited by PAβN in the resistance to carbapenems in Chilean clinical isolates of K. pneumoniae harbouring the gene blaKPC. METHODS: Minimum Inhibitory Concentration (MIC) was determined by the agar dilution method for imipenem, meropenem, ertapenem and ciprofloxacin in the presence and absence of PAβN (25mg/L)...
December 21, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29244077/population-pharmacokinetics-and-probability-of-target-attainment-of-ertapenem-administered-by-subcutaneous-or-intravenous-route-in-patients-with-bone-and-joint-infection
#6
Sylvain Goutelle, Florent Valour, Marie-Claude Gagnieu, Frédéric Laurent, Christian Chidiac, Tristan Ferry
Background: Ertapenem is a therapeutic option in patients with Gram-negative bone and joint infection (BJI). The subcutaneous (sc) route of administration is convenient in the outpatient setting and has shown favourable pharmacokinetics (PK), but available data on ertapenem are limited. Objectives: To perform population PK analysis and pharmacokinetic/pharmacodynamic (PK/PD) simulation of ertapenem administered by the intravenous (iv) or sc route to patients with BJI...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29239220/is-it-time-to-rethink-the-notion-of-carbapenem-sparing-therapy-against-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-bloodstream-infections-a-critical-review
#7
Daniel B Chastain, Bryan P White, David A Cretella, Christopher M Bland
OBJECTIVE: To present systematic recommendations for carbapenem-sparing therapy against extended-spectrum β-lactamases (ESBLs) Enterobacteriaceae bloodstream infections (BSIs) derived from a critical review of clinical data. DATA SOURCES: A systematic literature search using PubMed and MEDLINE databases (January 1, 2012, to June 30, 2017) was performed using key MESH terms: ESBL or extended-spectrum β-lactamases and bacteremia or bloodstream infection with piperacillin/tazobactam, ciprofloxacin, levofloxacin, cefepime, cephamycins, carbapenem, doripenem, meropenem, and ertapenem...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29238212/effects-of-an-antimicrobial-restriction-system-on-appropriate-carbapenem-use-in-a-hospital-without-infectious-diseases-consultation
#8
Warangkhana Wanla, Wasan Katip, Sakon Supakul, Porntipa Apiwatnakorn, Sompong Khamsarn
Background: Gram-negative bacteria are becoming increasingly resistant to carbapenems and are related to the use of carbapenems. Thus, the main objective of this study was to compare the appropriateness of prescribing carbapenem before and after using an antimicrobial restriction system without infectious diseases consultation. Materials and methods: A retrospective cross-sectional before and after study was conducted in Lamphun Hospital to limit the prescription of carbapenems...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29230108/letter-to-the-editor-ertapenem-induced-acute-pancreatitis-in-a-cirrhotic-patient
#9
Erkin Oztas, Muhammet Yener Akpinar, Mustafa Kaplan
No abstract text is available yet for this article.
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29228202/activity-of-ceftazidime-avibactam-against-problem-enterobacteriaceae-and-pseudomonas-aeruginosa-in-the-uk-2015-16
#10
David M Livermore, Danièle Meunier, Katie L Hopkins, Michel Doumith, Robert Hill, Rachel Pike, Peter Staves, Neil Woodford
Background: Ceftazidime/avibactam combines an established oxyimino-cephalosporin with the first diazabicyclooctane β-lactamase inhibitor to enter clinical use. We reviewed its activity against Gram-negative isolates, predominantly from the UK, referred for resistance investigation in the first year of routine testing, beginning in July 2015. Methods: Isolates were as received from referring laboratories; there is a bias to submit those with suspected carbapenem resistance...
December 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29204354/unusual-carbapenem-resistant-but-ceftriaxone-and-cefepime-susceptible-klebsiella-oxytoca-isolated-from-a-blood-culture-case-report-and-whole-genome-sequencing-investigation
#11
Shangxin Yang, Peera Hemarajata, Laura Shevy, Mario Maciariello, Karissa Culbreath, Karen Bush, Romney Humphries
A carbapenem resistant but ceftriaxone and cefepime susceptible Klebsiella oxytoca was isolated from the blood of a patient with polymicrobial bacteremia after 2 weeks of ertapenem treatment. Whole-genome sequencing identified no carbapenemase gene nor plasmid, but only blaOXY-2-8 gene with a mutation in the promoter that's been reported to increase its expression. Two other specific carbapenem resistance mechanisms including mutated porin genes and the AcrAB-TolC efflux system genes were also identified. Clinicians need to be aware of such unusual antibiogram and should not assume carbapenems are always broader spectrum antibiotics than expanded-spectrum cephalosporins...
2018: IDCases
https://www.readbyqxmd.com/read/29183082/hidradenitis-suppurativa-advances-in-diagnosis-and-treatment
#12
REVIEW
Ditte Marie Lindhardt Saunte, Gregor Borut Ernst Jemec
Importance: Hidradenitis suppurativa (HS) is relatively common, with the prevalence of 0.05% to 4.10%, yet many patients receive inadequate treatment. Objective: To review the diagnosis, epidemiology, and treatment of HS with an emphasis on advances in the last 5 years. Evidence Review: A literature search was conducted using PubMed, MEDLINE (Medical Subject Headings [MeSH]), and EMBASE to include recently published treatment studies (searched from September 1, 2011, to May 1, 2017)...
November 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29151282/epidemiology-and-impact-of-bloodstream-infections-among-kidney-transplant-recipients-a-retrospective-single-center-experience
#13
Ali M Shendi, Gabriel Wallis, Helena Painter, Mark Harber, Sophie Collier
BACKGROUND: Bloodstream infections (BSI) represent an important source of morbidity and mortality, as well as an increasing therapeutic challenge, among solid organ transplant recipients. Understanding the epidemiological and microbiological characteristics of BSI following renal transplantation is paramount to the implementation of appropriate preventative and therapeutic measures. METHODS: We conducted a retrospective review of all BSI episodes occurring between July 2009 and April 2016 in adult patients, who received a renal transplant at Royal Free London hospital...
November 19, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29147640/robinsoniella-peoriensis-infection-related-to-right-femoral-hardware
#14
Justin Schmetterer, Joseph Gorvetzian, Shaun Yang
Discovered in swine manure relatively recently, Robsinoniella peoriensis is a gram-positive anaerobic bacilli that has been reported to cause human infections. Its antimicrobial susceptibility, epidemiology and overall pathogenicity are still not fully understood. We report a case of a hardware related soft tissue infection in the right femur caused by Robinsoneilla peoriensis following an open reduction internal fixation in a 67 year old immunocompetent woman. The patient was successfully treated with six weeks of ertapenem...
2017: IDCases
https://www.readbyqxmd.com/read/29133551/copper-ions-and-coordination-complexes-as-novel-carbapenem-adjuvants
#15
Karrera Y Djoko, Maud E S Achard, Minh-Duy Phan, Alvin W Lo, Manfredi Miraula, Sasiprapa Prombhul, Steven J Hancock, Kate M Peters, Hanna Sidjabat, Patrick N Harris, Nataša Mitić, Timothy R Walsh, Gregory J Anderson, William M Shafer, David L Paterson, Gerhard Schenk, Alastair G McEwan, Mark A Schembri
Carbapenem-resistant Enterobacteriaceae are an urgent threat to global human health. These organisms produce β-lactamases with carbapenemase activity, such as the metallo-β-lactamase NDM-1, which is notable due to its association with mobile genetic elements and the lack of a clinically useful inhibitor. Here we examined the ability of copper to inhibit the activity of NDM-1 and explored the potential of a copper coordination complex as a mechanism to efficiently deliver copper as an adjuvant in clinical therapeutics...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29120560/klebsiella-pneumoniae-oxa-48-in-a-urology-patient-case-report
#16
Ines Jajić, Ana Benčić, Marko Siroglavić, Gernot Zarfel, Boris Ružić, Ivan Pezelj, Branka Bedenić
We present an isolate of Klebsiella pneumoniae OXA-48 isolated in a 68-year-old man who underwent radical prostatectomy due to prostate cancer. The antibiotic susceptibility testing to a wide range of antibiotics was performed by disk diffusion method and determination of minimal inhibitory concentrations. The isolate was classified as multidrug-resistant. It showed intermediate susceptibility to imipenem and meropenem, resistance to ertapenem, and sensitivity only to colistin, amikacin, and trimethoprim-sulfamethoxazole...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29119027/dosing-of-ertapenem-in-an-extreme-obesity-a-case-report-of-250%C3%A2-kg-patient
#17
Jana Lass, Kadri Tamme, Karin Kipper, Joel Starkopf
Limited available data for dosing in obesity of the medicines used in this case are discussed, with the emphasis on ertapenem. The case illustrates the difficulties in dosing medicines to morbidly overweight patients. The number of such patients is increasing but data on adequate doses of medicines are scarce. We demonstrate that ertapenem 1,5 g i.v. once daily provided adequate drug exposure for susceptible bacteria in a 250 kg patient with normal renal function. The case suggests the usefulness of therapeutic drug monitoring of antibiotics, especially in critically ill patients...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29113933/spread-of-klebsiella-pneumoniae-st395-non-susceptible-to-carbapenems-and-resistant-to-fluoroquinolones-in-north-eastern-france
#18
Anaëlle Muggeo, Thomas Guillard, Frédéric Klein, Fany Reffuveille, Caroline François, Anamaria Babosan, Odile Bajolet, Xavier Bertrand, Christophe de Champs
Fluoroquinolones (FQ) are potential treatments to treat infections from extended-spectrum β-lactamase producing-Enterobacteriaceae susceptible to FQ. Due to increasing non-susceptibility to carbapenems among Enterobacteriaceae, we characterized FQ resistance mechanisms in 36 Klebsiella pneumoniae isolates that are non-susceptible to ertapenem in North-Eastern France in 2012 and described the population structure by pulsed field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Among them, 36% (13/36) carried a carbapenemase encoding-gene...
November 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29109580/fosfomycin-susceptibility-in-multidrug-resistant-enterobacteriaceae-species-and-vancomycin-resistant-enterococci-urinary-isolates
#19
Linda B Ou, Lynn Nadeau
Background: Broad-spectrum antibiotics are often used to treat urinary tract infections (UTIs) due to drug-resistant species of Enterobacteriaceae and Enterococcus (e.g., organisms producing extended-spectrum β-lactamase [ESBL] or AmpC β-lactamase, as well as vancomycin-resistant enterococci [VRE]). However, this type of therapy can promote selection of resistant organisms and may necessitate venous access. Fosfomycin is an orally administered, single-dose antibiotic for the treatment of uncomplicated UTI...
September 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29099915/carbapenem-resistant-enterobacteriaceae-cre-detection-practices-in-california-what-are-we-missing
#20
Romney M Humphries, Janet A Hindler, Erin Epson, Sam Horwich-Scholefield, Loren G Miller, Job Mendez, Jeremias B Martinez, Jacob Sinkowitz, Darren Sinkowtiz, Christina Hershey, Patricia Marquez, Sandeep Bhaurla, Marcelo Moran, Lindsey Pandes, Dawn Terashita, James A McKinnell
Background: The Clinical and Laboratory Standards Institute (CLSI) revised carbapenem breakpoints for the Enterobacteriaceae in 2010. The number of hospitals that adopted revised CLSI breakpoints and the clinical impact of delayed adoption has not been previously explored. Methods: We performed a cross-sectional, voluntary survey of microbiology laboratories that serve California acute care hospitals and long-term acute care hospitals (LTAC) to determine use of revised CLSI breakpoints...
November 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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