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https://www.readbyqxmd.com/read/27909893/osteogain%C3%A2-loaded-onto-an-absorbable-collagen-sponge-induces-attachment-and-osteoblast-differentiation-of-st2-cells-in-vitro
#1
Richard J Miron, Masako Fujioka-Kobayashi, Yufeng Zhang, Anton Sculean, Benjamin Pippenger, Yoshinori Shirakata, Umadevi Kandalam, Maria Hernandez
OBJECTIVES: Dimensional changes of the alveolar bone following tooth extraction are a major challenge in daily dental practice. To limit bone loss, a variety of biomaterials including bone grafts, barrier membranes, and growth factors have been utilized either alone or in combination therapies to increase the speed and quality of new bone formation. The aim of the present in vitro study was to investigate the regenerative potential of Osteogain®, a new liquid carrier system of enamel matrix derivative (EMD) in combination with an absorbable collagen sponge (ACS) specifically designed for extraction socket healing...
December 1, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27900334/serum-levels-of-soluble-st2-and-il-10-are-associated-with-disease-severity-in-patients-with-iga-nephropathy
#2
Zhihui Zhang, Haifeng Wang, Li Zhang, Rebecca Crew, Nan Zhang, Xiaolei Liu, Yanfang Jiang
Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27890443/oxa-23-and-isaba1-oxa-66-class-d-%C3%AE-lactamases-in-acinetobacter-baumannii-isolates-from-companion-animals
#3
Christa Ewers, Peter Klotz, Ursula Leidner, Ivonne Stamm, Ellen Prenger-Berninghoff, Stephan Göttig, Torsten Semmler, Sandra Scheufen
Acinetobacter baumannii is recognised as a major pathogen of nosocomial infections that frequently show resistance to last-resort antimicrobials. To investigate whether A. baumannii from companion animals harbour carbapenem resistance mechanisms, 223 clinical isolates obtained from veterinary clinics between 2000 and 2013 in Germany were screened for carbapenem-non-susceptibility employing meropenem-containing Mueller-Hinton agar plates. Minimum inhibitory concentration (MIC) data were obtained using the VITEK(®)2 system...
November 16, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27887774/rationale-and-study-design-of-respite-an-open-label-phase-3b-study-of-riociguat-in-patients-with-pulmonary-arterial-hypertension-who-demonstrate-an-insufficient-response-to-treatment-with-phosphodiesterase-5-inhibitors
#4
Marius M Hoeper, James R Klinger, Raymond L Benza, Gerald Simonneau, David Langleben, Robert Naeije, Paul A Corris
Patients with pulmonary arterial hypertension (PAH) who do not have an adequate response to therapy with phosphodiesterase-5 inhibitors (PDE-5i) may have insufficient synthesis of cyclic guanosine monophosphate (cGMP). These patients may respond to a direct soluble guanylate cyclase (sGC) stimulator such as riociguat. RESPITE (NCT02007629) was an open-label, multicenter, uncontrolled, single-arm phase 3b study of riociguat in patients with PAH who demonstrated an insufficient response to treatment with PDE-5i...
November 5, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27873073/mir-5100-promotes-osteogenic-differentiation-by-targeting-tob2
#5
Huaxin Wang, Yazhou Cui, Jing Luan, Xiaoyan Zhou, Chengzhi Li, Haiying Li, Liang Shi, Jinxiang Han
MicroRNAs have emerged as pivotal regulators in various physiological and pathological processes, including osteogenesis. Here we discuss the contribution of miR-5100 to osteoblast differentiation and mineralization. We found that miR-5100 was upregulated during osteoblast differentiation in ST2 and MC3T3-E1 cells. Next, we verified that miR-5100 can promote osteogenic differentiation with gain-of-function and loss-of-function experiments. Target prediction analysis and experimental validation demonstrated that Tob2, which acts as a negative regulator of osteogenesis, was negatively regulated by miR-5100...
November 21, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27872212/a-proinflammatory-role-of-type-2-innate-lymphoid-cells-in-murine-immune-mediated-hepatitis
#6
Katrin Neumann, Khalil Karimi, Jana Meiners, Ruth Voetlause, Silja Steinmann, Werner Dammermann, Stefan Lüth, Farahnaz Asghari, Claudia Wegscheid, Andrea K Horst, Gisa Tiegs
Type 2 innate lymphoid cells (ILC2) mediate inflammatory immune responses in the context of diseases triggered by the alarmin IL-33. In recent years, IL-33 has been implicated in the pathogenesis of immune-mediated liver diseases. However, the immunoregulatory function of ILC2s in the inflamed liver remains elusive. Using the murine model of Con A-induced immune-mediated hepatitis, we showed that selective expansion of ILC2s in the liver was associated with highly elevated hepatic IL-33 expression, severe liver inflammation, and infiltration of eosinophils...
November 21, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27868262/adipocytes-enhance-expression-of-osteoclast-adhesion-related-molecules-through-the-cxcl12-cxcr4-signalling-pathway
#7
Tingting Luo, Hongrui Liu, Wei Feng, Di Liu, Juan Du, Jing Sun, Wei Wang, Xiuchun Han, Jie Guo, Norio Amizuka, Xianqi Li, Minqi Li
OBJECTIVES: The purpose of this study was to investigate effects of adipocytes on osteoclast adhesion-related molecules. MATERIALS AND METHODS: ST2 cells, a cloned stromal cell line from mouse bone marrow, able to differentiate into adipocytes, were cultured in serum-free α-MEM which was then collected to be used as adipocyte-conditioned medium (ADIPO CM). RAW264.7 cells were cultured in ADIPO CM in the presence of RANKL, and bone marrow-derived macrophages were cultured in ADIPO CM in the presence of RANKL and macrophage-colony stimulating factor to induce osteoclast differentiation...
November 21, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27862491/alarmins-and-central-nervous-system-inflammation-in-hiv-associated-neurological-disorders
#8
M-L Gougeon
In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorders (HAND) persist in infected individuals with adequate immunological and virological status. Risk factors for cognitive impairment include hepatitis C virus co-infection, host genetic factors predisposing to HAND, the early establishment of the virus in the CNS and its persistence under HAART; thus, the CNS is an important reservoir for HIV. Microglial cells are permissive to HIV-1, and NLRP3 inflammasome-associated genes were found expressed in brains of HIV-1-infected persons, contributing to brain disease...
November 16, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27861617/the-systematic-investigation-of-the-quorum-sensing-system-of-the-biocontrol-strain-pseudomonas-chlororaphis-subsp-aurantiaca-pb-st2-unveils-auri-to-be-a-biosynthetic-origin-for-3-oxo-homoserine-lactones
#9
Judith S Bauer, Nils Hauck, Lisa Christof, Samina Mehnaz, Bertolt Gust, Harald Gross
The shoot endophytic biocontrol strain Pseudomonas chlororaphis subsp. aurantiaca PB-St2 produces a wide range of exoproducts, including enzymes and antibiotics. The production of exoproducts is commonly tightly regulated. In order to get a deeper insight into the regulatory network of PB-St2, the strain was systematically investigated regarding its quorum sensing systems, both on the genetic and metabolic level. The genome analysis of PB-St2 revealed the presence of four putative acyl homoserine lactone (AHL) biosynthesis genes: phzI, csaI, aurI, and hdtS...
2016: PloS One
https://www.readbyqxmd.com/read/27859778/molecular-epidemiology-of-staphylococcus-epidermidis-in-neonatal-intensive-care-units
#10
Hiie Soeorg, Kristi Huik, Ülle Parm, Mari-Liis Ilmoja, Tuuli Metsvaht, Irja Lutsar
Late-onset sepsis (LOS) in preterm neonates is increasingly reported to be associated with gut-colonizing Staphylococcus epidermidis. We aimed to describe the molecular epidemiology of S. epidermidis colonizing the gut of neonates hospitalized in two neonatal intensive care units. S. epidermidis from rectal swabs were typed by multilocus variable-number tandem-repeat analysis (MLVA), randomly chosen isolates of predominant MLVA types additionally by multilocus sequence typing. Antimicrobial susceptibility, the presence of icaA, IS256, arginine catabolic mobile element (ACME), agr type, and SCCmec type were determined...
November 16, 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27827824/plasma-biomarkers-of-risk-for-death-in-a-multicenter-phase-3-trial-with-uniform-transplant-characteristics-post-allogeneic-hct
#11
Mohammad Abu Zaid, Juan Wu, Cindy Wu, Brent R Logan, Jeffrey Yu, Corey Cutler, Joseph H Antin, Sophie Paczesny, Sung Won Choi
A phase 3 clinical trial (BMT CTN 0402) comparing tacrolimus/sirolimus (Tac/Sir) versus tacrolimus/methotrexate (Tac/Mtx) as graft-versus-host disease (GVHD) prophylaxis after matched-related allogeneic hematopoietic cell transplantation (HCT) recently showed no difference between study arms in acute GVHD-free survival. Within this setting of a prospective, multicenter study with uniform GVHD prophylaxis, conditioning regimen, and donor source, we explored the correlation of 10 previously identified biomarkers with clinical outcomes after allogeneic HCT...
November 8, 2016: Blood
https://www.readbyqxmd.com/read/27826340/role-of-soluble-st2-as-a-marker-for-rejection-after-heart-transplant
#12
Ga Yeon Lee, Jin-Oh Choi, Eun-Seon Ju, Yoo-Jung Lee, Eun-Seok Jeon
BACKGROUND AND OBJECTIVES: Endomyocardial biopsy is obligatory during the first year after heart transplant (HTx) for the surveillance of acute rejection. Previous attempts using cardiac biomarkers for the detection of rejection failed to show enough evidence to substitute endomyocardial biopsy. Therefore, this study sought the possibility of using soluble ST2 (sST2), a novel cardiovascular marker, as a surrogate marker for acute allograft rejection after HTx. SUBJECTS AND METHODS: A total of 494 blood samples acquired at the time of endomyocardial biopsy were analyzed in 67 HTx cases from September 2006 to August 2014...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27821781/il-33-st2-signaling-excites-sensory-neurons-and-mediates-itch-response-in-a-mouse-model-of-poison-ivy-contact-allergy
#13
Boyi Liu, Yan Tai, Satyanarayana Achanta, Melanie M Kaelberer, Ana I Caceres, Xiaomei Shao, Jianqiao Fang, Sven-Eric Jordt
Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing content of the allergen, urushiol, likely attributable to rising atmospheric CO2 Severe and treatment-resistant itch is the major complaint of affected patients. However, because of limited clinical data and poorly characterized models, the pruritic mechanisms in poison ivy ACD remain unknown...
November 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27816512/prognostic-value-of-soluble-suppression-of-tumorigenicity-2-in-chronic-heart-failure-a-meta-analysis
#14
Alberto Aimo, Giuseppe Vergaro, Claudio Passino, Andrea Ripoli, Bonnie Ky, Wayne L Miller, Antoni Bayes-Genis, Inder Anand, James L Januzzi, Michele Emdin
OBJECTIVES: The purpose of this study was to perform the first meta-analysis of currently available data. BACKGROUND: Soluble suppression of tumorigenesis 2 (sST2) plasma concentration is elevated in chronic heart failure (CHF) and helps to predict prognosis in this setting, although the evidence is limited. METHODS: Three databases (Medline, Cochrane Library, and Scopus) were searched. Inclusion criteria were: follow-up studies; papers published in English; enrollment of CHF outpatients; available data on hazard ratio (HR) for the log2 ST2 (so that the reported HRs represent the risk per doubling of sST2) and 95% confidence interval (CI) for all-cause death, and possibly also for cardiovascular (CV) death; and use of standardized sST2 assay...
October 27, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27813304/biomarker-based-risk-prediction-in-the-community
#15
Omar F AbouEzzeddine, Paul M McKie, Christopher G Scott, Richard J Rodeheffer, Horng H Chen, G Michael Felker, Allan S Jaffe, John C Burnett, Margaret M Redfield
AIMS: Guided by predictive characteristics of cardiovascular biomarkers, we explored the clinical implications of a simulated biomarker-guided heart failure (HF) and major adverse cardiovascular events (MACE) prevention strategy in the community. METHODS AND RESULTS: In a community cohort (n = 1824), the predictive characteristics for HF and MACE of galectin-3 (Gal-3), ST2, high-sensitivity cardiac troponin I (hscTnI), high-sensitivity C-reactive protein (hsCRP), N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP) were established...
November 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27809845/impact-of-diabetes-on-the-predictive-value-of-heart-failure-biomarkers
#16
Nuria Alonso, Josep Lupón, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Pedro Moliner, Amparo Galán, Javier Santesmases, Cruz Pastor, Dídac Mauricio, Antoni Bayes-Genis
BACKGROUND: Patients with diabetes mellitus (DM) have an increased risk of developing heart failure (HF). Further, DM is associated with poor prognosis in patients with HF. Our aim was to determine whether DM has any impact on the predictive value of a multi-biomarker panel in patients with HF. METHODS: We included 1069 consecutive ambulatory HF patients in the study: age 66.2 ± 12.8 years, 33.5 ± 13.3 left ventricular ejection fraction, 36% diabetic patients...
November 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27807655/profile-of-citrobacter-freundii-st2-a-multi-acyl-homoserine-lactone-producer-associated-with-marine-dinoflagellates
#17
Xinqi Huang, Yan Gao, Zhiping Ma, Guanghui Lin, Zhonghua Cai, Jin Zhou
Marine algae provide a unique niche termed the phycosphere for microorganism inhabitation. The phycosphere environment is an important niche for mutualistic and competitive interactions between algae and bacteria. Quorum sensing (QS) serves as a gene regulatory system in the microbial biosphere that allows bacteria to sense the population density with signaling molecules, such as acyl-homoserine lactone (AHL), and adapt their physiological activities to their surroundings. Understanding the QS system is important to elucidate the interactions between algal-associated microbial communities in the phycosphere condition...
November 2, 2016: Current Microbiology
https://www.readbyqxmd.com/read/27798759/soluble-st2-and-risk-of-arrhythmias-heart-failure-or-death-in-patients-with-mildly-symptomatic-heart-failure-results-from-madit-crt
#18
Hicham Skali, Robert Gerwien, Timothy E Meyer, James V Snider, Scott D Solomon, Craig M Stolen
Soluble ST2 is an established biomarker of heart failure (HF) progression. Data about its prognostic implications in patients with mildly symptomatic HF eligible to receive cardiac resynchronization therapy defibrillators (CRT-D) are limited. In a cohort of 684 patients enrolled in Multicenter Automated Defibrillator Implantation Trial (MADIT)-CRT, levels of soluble ST2 (sST2) were serially assessed at baseline and 1 year (n = 410). In multivariable-adjusted models, elevated baseline sST2 was associated with an increased risk of death, death or HF, and death or ventricular arrhythmia (VA) even when adjusting for baseline brain natriuretic protein (BNP) levels...
October 31, 2016: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/27796360/pollen-tlr4-innate-immunity-signaling-initiates-il-33-st2-th2-pathways-in-allergic-inflammation
#19
Jin Li, Lili Zhang, Xin Chen, Ding Chen, Xia Hua, Fang Bian, Ruzhi Deng, Fan Lu, Zhijie Li, Stephen C Pflugfelder, De-Quan Li
Innate immunity has been extended to respond environmental pathogen other than microbial components. Here we explore a novel pollen/TLR4 innate immunity in allergic inflammation. In experimental allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated IL-33/ST2 signaling and overproduced Th2 cytokine were observed in ocular surface, cervical lymph nodes and isolated CD4(+) T cells of BALB/c mice. These clinical, cellular and molecular changes were significantly reduced/eliminated in TLR4 deficient (Tlr4-d) or MyD88 knockout (MyD88(-/-)) mice...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792746/fetal-lymphoid-progenitors-become-restricted-to-b-1-fates-coincident-with-il-7r%C3%AE-expression
#20
Ryuji Iida, Kaori Shinoda, Yuki Hayano, Yoshinori Nagai, Kiyoshi Takatsu, Taku Kouro
B-1 cells represent a sub-fraction of B lymphocytes that participate in T cell-independent antibody production and contribute to innate immunity. While the production of B-1 cells is favored during the fetal waves of lymphopoiesis, it has been unclear when and how that differentiation option is specified. To clarify this, lymphoid and hematopoietic progenitors of fetal liver (FL) and adult bone marrow (ABM) were examined for the B cell differentiation potential. Mouse common lymphoid progenitors (CLPs) and more primitive KSL fraction of FL and ABM were transferred to SCID mice and donor-derived B cell subsets were analyzed 4 weeks later...
2016: PloS One
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