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https://www.readbyqxmd.com/read/28932392/galectin-3-a-marker-of-cardiac-remodeling-is-inversely-related-to-serum-levels-of-marine-omega-3-fatty-acids-a-cross-sectional-study
#1
K Laake, I Seljeflot, E B Schmidt, P Myhre, A Tveit, J Norseth, H Arnesen, S Solheim
OBJECTIVE: Marine polyunsaturated n-3 fatty acids (n-3 PUFA) may have cardioprotective effects and beneficial influence on the fibrotic process. We evaluated the associations between serum marine n-3 PUFA and selected biomarkers of fibrosis and cardiac remodeling in elderly patients with acute myocardial infarction. SETTING: From the ongoing OMega-3 fatty acids in Elderly patients with Myocardial Infarction (OMEMI) trial, 299 patients were investigated. Soluble ST2 (sST2), Galectin-3 (Gal-3) and the serum content of major marine n-3 and n-6 PUFA were analyzed 2-8 weeks after the index acute myocardial infarction...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28930661/il-1-family-cytokines-use-distinct-molecular-mechanisms-to-signal-through-their-shared-co-receptor
#2
Sebastian Günther, Daniel Deredge, Amanda L Bowers, Alessandra Luchini, Daniel A Bonsor, Robert Beadenkopf, Lance Liotta, Patrick L Wintrode, Eric J Sundberg
Within the interleukin 1 (IL-1) cytokine family, IL-1 receptor accessory protein (IL-1RAcP) is the co-receptor for eight receptor-cytokine pairs, including those involving cytokines IL-1β and IL-33. Unlike IL-1β, IL-33 does not have a signaling complex that includes both its cognate receptor, ST2, and the shared co-receptor IL-1RAcP, which we now present here. Although the IL-1β and IL-33 complexes shared structural features and engaged identical molecular surfaces of IL-1RAcP, these cytokines had starkly different strategies for co-receptor engagement and signal activation...
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28919197/imported-poultry-meat-as-a-source-of-extended-spectrum-cephalosporin-resistant-cmy-2-producing-salmonella-heidelberg-and-s-minnesota-in-european-union-2014-2015
#3
Joana Campos, Joana Mourão, Leonor Silveira, Margarida Saraiva, Cristina Belo Correia, Ana Paula Maçãs, Luísa Peixe, Patrícia Antunes
Extended-spectrum cephalosporin (ESC)-resistant Salmonella has been described at low level in EU, nevertheless the increasing importation of poultry meat could be an important source of epidemic strains carrying ESC-resistant genes. We evaluated ESC resistance and characterized genetic platforms as well as the clonal relatedness of Salmonella isolates from poultry meat products imported into Portugal. All Salmonella isolates recovered from samples of fresh meat destined to be imported into the EU in the scope of Portuguese official border control between 2014 and 2015 were studied...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28916390/il-33-receptor-st2-deficiency-attenuates-renal-ischaemia-reperfusion-injury-in-euglycaemic-but-not-streptozotocin-induced-hyperglycaemic-mice
#4
M Sehnine, M Ferhat, S Sena, J M Gombert, J M Goujon, A Thierry, G Touchard, T Hauet, A Herbelin, S Hadjadj
AIM: Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus, the present study examined the impact of genetic IL-33 receptor ST2 deficiency (ST2-/-) on renal IRI in euglycaemic and hyperglycaemic mice. METHODS: Hyperglycaemia was induced with streptozotocin (STZ) in adult male C57BL/6JRj wild-type (WT) mice and ST2-/- mice...
September 12, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28887122/blastocystis-subtypes-detected-in-long-tailed-macaques-in-thailand-further-evidence-of-cryptic-host-specificity
#5
Kotchaphon Vaisusuk, Weerachai Saijuntha, Sutthira Sedlak, Thongchit Thanchomnang, Warayutt Pilap, Warong Suksavate, Christen Rune Stensvold, Chairat Tantrawatpan
Blastocystis is an enteric parasitic protist with a widespread distribution in a variety of human and non-human hosts and supposedly a source of zoonotic transmission. This study aimed to determine the frequency and distribution of Blastocystis subtypes in free-ranging Macaca fascicularis (long-tailed macaques, LTMs) in Thailand. A total of 628 faecal samples were collected from free-ranging LTMs inhabiting fourteen tourist attraction sites in Thailand. Fresh faecal samples were individually cultured in Jones' medium, and Blastocystis-positive samples were subtyped using nuclear small subunit ribosomal DNA (SSU rDNA) sequencing...
September 5, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28881817/dectin-1-signaling-inhibits-osteoclastogenesis-via-il-33-induced-inhibition-of-nfatc1
#6
Xiaoqing Zhu, Yinghua Zhao, Yuxue Jiang, Tianxue Qin, Jintong Chen, Xiao Chu, Qing Yi, Sujun Gao, Siqing Wang
Abnormal osteoclast activation contributes to osteolytic bone diseases (OBDs). It was reported that curdlan, an agonist of dectin-1, inhibits osteoclastogenesis. However, the underlying mechanisms are not fully elucidated. In this study, we found that curdlan potently inhibited RANKL-induced osteoclast differentiation and the resultant bone resorption. Curdlan inhibited the expression of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), the key transcriptional factor for osteoclastogenesis. Notably, dectin-1 activation increased the expression of MafB, an inhibitor of NFATc1, and IL-33 in osteoclast precursors...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881679/mir-487b-mitigates-chronic-heart-failure-through-inhibition-of-the-il-33-st2-signaling-pathway
#7
En-Wei Wang, Xu-Sheng Jia, Chang-Wu Ruan, Zhi-Ru Ge
We investigated the effects of microRNA-587b (miR-487b) in a rat model of chronic heart failure (CHF). Wistar rats were assigned to 10 groups (n=8 per group). Expression of interleukin-33 (IL-33), somatostatin 2 (ST2), IL-6, and TNF-α was higher in the CHF group than the control group. In the CHF, negative control (NC) for si-IL-33, NC for miR-487b mimic, NC for miR-487b inhibitor, and miR-487b inhibitor + si IL-33 groups, as compared to the blank and sham groups: steroid binding protein (SBP), D binding protein (DBP), left ventricular systolic pressure (LVSP), ± dp/dtmax, and superoxide dismutase (SOD) were all lower; myocardial fibrosis, MDA, left ventricular end-diastolic pressure (LVEDP), myocardial apoptosis rate, IL-6, and TNF-α were all higher; levels of IL-33 and ST2 mRNA and protein were higher; and levels of miR-487b were lower...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878285/interleukin-33-promotes-inflammation-induced-lymphangiogenesis-via-st2-traf6-mediated-akt-enos-no-signalling-pathway
#8
Longhui Han, Minglian Zhang, Xu Liang, Xin Jia, Jinchen Jia, Miying Zhao, Yiming Fan
The interplay between inflammation and lymphangiogenesis is mediated by various cytokines. However, most of these molecules and their associated mechanism are yet to be defined. Here, we explored the role of IL-33 in modulating inflammation-induced lymphangiogenesis (ILA) and its underlying mechanisms using an ILA mouse model and a lymphatic endothelial cell (LEC) line. Our results show that IL-33 promoted the proliferation, migration and tube formation of LECs and ILA in vivo. The pro-lymphangiogenic activity of IL-33 was abolished by ST2 blockage...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878123/the-r213g-polymorphism-in-sod3-protects-against-allergic-airway-inflammation
#9
Rohit Gaurav, Jason T Varasteh, Michael R Weaver, Sean R Jacobson, Laura Hernandez-Lagunas, Qing Liu, Eva Nozik-Grayck, Hong Wei Chu, Rafeul Alam, Børge G Nordestgaard, Camilla J Kobylecki, Shoaib Afzal, Geoffrey L Chupp, Russell P Bowler
Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood of asthma-related symptoms. Knockin mice analogous to the human R213G SNP had lower airway hyperresponsiveness, inflammation, and mucus hypersecretion with decreased interleukin-33 (IL-33) in bronchoalveolar lavage fluid and reduced type II innate lymphoid cells (ILC2s) in lungs...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28875838/biomarkers-in-atrial-fibrillation-and-heart-failure
#10
Evangelos Oikonomou, Theodoros Zografos, Georgios-Angelos Papamikroulis, Gerasimos Siasos, Georgia Vogiatzi, Panagiotis Theofilis, Alexandros Briasoulis, Spyridon Papaioannou, Manolis Vavuranakis, Vasiliki Gennimata, Dimitris Tousoulis
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice and an important contributor to cardiovascular morbidity and mortality. Although the exact mechanisms behind AF are not completely elucidated, the underlying pathophysiological changes have been well described. Predisposal factors for AF include the older age, the increased left atrial size, the decreased left atrial function, the presence of heart failure and left ventricular systolic dysfunction and the presence of coronary heart disease or pulmonary or mitral valve disease...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28870670/il-1-receptor-like-1-protects-against-alcoholic-liver-injury-by-limiting-nf-%C3%AE%C2%BAb-activation-in-hepatic-macrophages
#11
Meng Wang, Guannan Shen, Liangguo Xu, Xiaodong Liu, Jared M Brown, Dechun Feng, Ruth Ann Ross, Bin Gao, Suthat Liangpunsakul, Cynthia Ju
BACKGROUND & AIM: Alcohol consumption, through increasing intestinal permeability and causing hepatocytes damage, leads to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs). These molecules stimulate hepatic macrophages (MΦs) and activate NF-κB, resulting in inflammation and exacerbating alcoholic liver disease (ALD). However, much less is known about the mechanisms attenuating inflammation and preventing disease progression in the majority of the heavy drinkers...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28860791/soluble-st2-correlates-with-some-indicators-of-right-ventricular-function-in-hypertensive-heart-failure
#12
Dike B Ojji, Sandrine Lecour, Olusoji M Adeyemi, Karen Sliwa
PURPOSE: ST2 receptor, which is a member of the Toll-like/interleukin-1 (IL-1) receptor family, has been found to be increased in the serum of patients 1 day after myocardial infarction. Several other studies have shown that soluble ST2 levels correlate with severity of heart failure (HF), left ventricular ejection fraction, creatinine clearance, B-type natriuretic peptide and C-reactive protein, and are predictors of mortality in HF. Most of these studies were not only limited to ischemic heart disease but also concentrated on left-sided HF...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28860510/a-functional-il1rl1-variant-regulates-corticosteroid-induced-sst2-expression-in-ulcerative-colitis
#13
David Díaz-Jiménez, Lucía Núñez, Marjorie De la Fuente, Karen Dubois-Camacho, Hugo Sepúlveda, Martín Montecino, Alejandro Torres-Riquelme, Paulina García-González, Jonás Chnaiderman, Anna Vossenkamper, Thomas T MacDonald, Daniela Simian, María-Julieta González, John A Cidlowski, Rodrigo Quera, Marcela A Hermoso
The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid treatment; however, the glucocorticoid-mediated molecular regulation remains unknown. We therefore tested whether genetic variants in the IL1RL1 distal promoter are involved in UC and affect glucocorticoid-mediated ST2 expression...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857821/serum-st2-level-is-an-independent-predictor-of-all-cause-mortality-in-hiv-infected-patients-aquitaine-cohort-france
#14
Rodolphe Thiébaut, Sophie Hue, Fabien Le Marec, Jean Daniel Lelièvre, Michel Dupon, Emile Foucat, Estibaliz Lazaro, François Dabis, Pierre Duffau, Linda Wittkop, Mathieu Surenaud, Isabelle Pellegrin, Christine Lacabaratz, Fabrice Bonnet, Yves Lévy
OBJECTIVE: To evaluate the predictive value of Soluble Suppression of Tumorigenicity 2 (sST2), a decoy receptor of IL-33 involved in several inflammatory and immune diseases, for death in HIV infection. DESIGN: Patients enrolled in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients, who had a plasma sample available in the bio-bank were systematically eligible. METHODS: sST2, sCD14 and IL6 were measured using Luminex® multiplex bead-based technology (R&D Systems) and a Bio-Plex 200 instrument (BioRad)...
August 28, 2017: AIDS
https://www.readbyqxmd.com/read/28857185/5-12-lipoxygenase-linked-cascade-contributes-to-the-il-33-induced-synthesis-of-il-13-in-mast-cells-thus-promoting-asthma-development
#15
MyungJa Ro, A-Jin Lee, Jae-Hong Kim
BACKGROUND: As asthma progresses, the levels of IL-33 in serum are markedly increased and contribute to asthmatic development and exacerbation. Mast cells, one of the principal effector cells in the pathogenesis of asthma, express high levels of the IL-33 receptor ST2 and have been shown to be activated by IL-33. Thus, IL-33 stimulates mast cells to produce Th2-type cytokines such as IL-13, thus contributing to asthmatic development. However, the signaling mechanism for IL-33-induced synthesis of Th2 cytokines, particularly IL-13, has not been fully elucidated in mast cells...
August 30, 2017: Allergy
https://www.readbyqxmd.com/read/28857184/pathogenicity-of-memory-th2-cells-is-linked-to-stage-of-allergic-rhinitis
#16
T Iinuma, Y Okamoto, Y Morimoto, T Arai, T Sakurai, S Yonekura, D Sakurai, K Hirahara, T Nakayama
BACKGROUND: Allergic rhinitis (AR) consists of three developmental stages that are based on the presence/absence of antigen-specific IgE and symptoms. The pathogenic Th2 (Tpath2) cells constitute a population of Th2 cells with additional potentially pathogenic characteristics. We examined the relationship between Tpath2 cells and the stages of allergic rhinitis by focusing on ST2, which is an IL-33 receptor. METHODS: Patients with Japanese cedar pollen-induced AR (JCP-AR) and healthy volunteers were divided into "nonsensitized," "asymptomatic sensitized (AS)," and "JCP-AR" groups...
August 30, 2017: Allergy
https://www.readbyqxmd.com/read/28853918/human-bronchial-epithelial-cell-derived-factors-from-severe-asthmatic-subjects-stimulate-eosinophil-differentiation
#17
Brittany M A Salter, Steven G Smith, Manali Mukherjee, Sophie Plante, Sakktee Krisna, Graeme Nusca, John Paul Oliveria, Anam Irshad, Gail M Gauvreau, Jamila Chakir, Parameswaran Nair, Roma Sehmi
RATIONALE: Activated bronchial epithelial cells release alarmins, including thymic stromal lymphopoietin (TSLP) that drive type 2 inflammatory responses. We hypothesize that bronchial epithelial-derived factors enhance in situ eosinophil differentiation and maturation from myeloid precursors, a process that is driven by an IL-5 rich micro-environment within asthma airways. METHODS: To assess the eosinophilopoietic potential of epithelial-derived factors, eosinophil/basophil colony forming units (Eo/B-CFU) were enumerated in 14-day methylcellulose cultures of blood-derived mononuclear cells (NAMNCs) incubated with bronchial epithelial cell supernatants (BECSN) from healthy non-atopic controls (NC; n = 8), mild atopic asthmatics (MA; n = 9) and severe asthmatics (SA; n = 5)...
August 30, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28853173/pharmacological-inhibition-of-s6k1-impairs-self-renewal-and-osteogenic-differentiation-of-bone-marrow-stromal-cells
#18
Xiaohui Gu, Xuejie Fu, Jihang Lu, Saijilafu, Bin Li, Zong-Ping Luo, Jianquan Chen
mTORC1 signaling not only plays important physiological roles in the regulation of proliferation and osteogenic differentiation of BMSCs, but also mediates exogenous Wnt-induced protein anabolism and osteoblast differentiation. However, the downstream effectors of the mTORC1 signaling in the above processes are still poorly understood. In this study, we explored the specific role of S6K1, one of the major targets of the mTORC1 pathway, in BMSCs self-renewal and osteogenic differentiation. We first found that S6K1 was active in primary mouse bone marrow stromal cells, and further activated upon osteogenic induction...
July 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28837129/large-scale-comparative-metagenomics-of-blastocystis-a-common-member-of-the-human-gut-microbiome
#19
Francesco Beghini, Edoardo Pasolli, Tin Duy Truong, Lorenza Putignani, Simone M Cacciò, Nicola Segata
The influence of unicellular eukaryotic microorganisms on human gut health and disease is still largely unexplored. Blastocystis spp. commonly colonize the gut, but its clinical significance and ecological role are currently unsettled. We have developed a high-sensitivity bioinformatic pipeline to detect Blastocystis subtypes (STs) from shotgun metagenomics, and applied it to 12 large data sets, comprising 1689 subjects of different geographic origin, disease status and lifestyle. We confirmed and extended previous observations on the high prevalence the microrganism in the population (14...
August 22, 2017: ISME Journal
https://www.readbyqxmd.com/read/28836625/corrigendum-il-33-st2-immune-responses-to-respiratory-bacteria-in-pediatric-asthma
#20
Isabella Hentschke, Anna Graser, Volker O Melichar, Alexander Kiefer, Theodor Zimmermann, Bettina Kroß, Patricia Haag, Paraskevi Xepapadaki, Nikolaos G Papadopoulos, Christian Bogdan, Susetta Finotto
This corrects the article DOI: 10.1038/srep43426.
August 24, 2017: Scientific Reports
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