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https://www.readbyqxmd.com/read/28739033/soluble-st2-for-risk-stratification-and-the-prediction-of-mortality-in-patients-undergoing-transcatheter-aortic-valve-implantation
#1
Anja Stundl, Nina-Sophie Lünstedt, Florian Courtz, Sandra Freitag-Wolf, Norbert Frey, Stefan Holdenrieder, Berndt Zur, Eberhard Grube, Georg Nickenig, Nikos Werner, Derk Frank, Jan-Malte Sinning
This study aimed to assess the prognostic value of soluble ST2 (sST2) for risk stratification in patients undergoing transcatheter aortic valve implantation (TAVI). In 461 patients undergoing TAVI, sST2 was determined at baseline and categorized into quartiles. An optimum cutoff of 29 ng/ml was calculated. Primary end point was 1-year all-cause mortality. Results were validated in an independent cohort. Patients with sST2 >29 ng/ml had an increased 30-day (9.7% vs 4.6%, p = 0.043) and 1-year mortality (38...
June 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28716110/phylogenic-analysis-of-human-bocavirus-detected-in-children-with-acute-respiratory-infection-in-yaounde-cameroon
#2
Sebastien Kenmoe, Marie-Astrid Vernet, Mohamadou Njankouo-Ripa, Véronique Beng Penlap, Astrid Vabret, Richard Njouom
OBJECTIVE: Human Bocavirus (HBoV) was first identified in 2005 and has been shown to be a common cause of respiratory infections and gastroenteritis in children. In a recent study, we found that 10.7% of children with acute respiratory infections (ARI) were infected by HBoV. Genetic characterization of this virus remains unknown in Central Africa, particularly in Cameroon Leeding us to evaluate the molecular characteristics of HBoV strains in Cameroonian children with ARI. RESULTS: Phylogenetic analysis of partial HBoV VP1/2 sequences showed a low level of nucleotide variation and the circulation of HBoV genotype 1 (HBoV-1) only...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28712670/production-and-regulation-of-interleukin-1-family-cytokines-at-the-materno-fetal-interface
#3
Louis M Scott, Aled H Bryant, April Rees, Billy Down, Ruth H Jones, Catherine A Thornton
IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-1α, IL-1β, IL-18, IL-33, IL-1Ra, IL-18BPa, ST2 and IL-1RAcP by placenta, choriodecidua and amnion. Caspase-dependent processing of IL-1α, IL-1β, IL-18, and IL-33 and the ability of IL-1α, IL-1β, IL-18, and IL-33 to regulate the production of IL-1RA, IL-18BPa, ST2 and IL-1RAcP was also determined...
July 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28710436/epithelial-derived-il-33-promotes-intestinal-tumorigenesis-in-apc-min-mice
#4
Zhengxiang He, Lili Chen, Fabricio O Souto, Claudia Canasto-Chibuque, Gerold Bongers, Madhura Deshpande, Noam Harpaz, Huaibin M Ko, Kevin Kelley, Glaucia C Furtado, Sergio A Lira
Increased expression of Interleukin (IL)-33 has been detected in intestinal samples of patients with ulcerative colitis, a condition associated with increased risk for colon cancer, but its role in the development of colorectal cancer has yet to be fully examined. Here, we investigated the role of epithelial expressed IL-33 during development of intestinal tumors. IL-33 expression was detected in epithelial cells in colorectal cancer specimens and in the Apc (Min/+) mice. To better understand the role of epithelial-derived IL-33 in the intestinal tumorigenesis, we generated transgenic mice expressing IL-33 in intestinal epithelial cells (V33 mice)...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708926/comparison-of-two-porcine-collagen-membranes-combined-with-rhbmp-2-and-rhbmp-9-on-osteoblast-behavior-in-vitro
#5
Masako Fujioka-Kobayashi, Benoit Schaler, Yoshinori Shirakata, Toshiaki Nakamura, Kazuyuki Noguchi, Yufeng Zhang, Richard J Miron
PURPOSE: To investigate the bone-inducing properties of two types of collagen membranes in combination with recombinant human bone morphogenetic protein (rhBMP)-2 and rhBMP-9 on osteoblast behavior. MATERIALS AND METHODS: Porcine pericardium collagen membranes (PPCM) and porcine dermis-derived collagen membranes (PDCM) were coated with either rhBMP-2 or rhBMP-9. The adsorption and release abilities were first investigated via enzyme-linked immunosorbent assay up to 10 days...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28704488/soluble-st2-does-not-change-cardiovascular-risk-prediction-compared-to-cardiac-troponin-t-in-kidney-transplant-candidates
#6
Mira T Keddis, Ziad El-Zoghby, Bruce Kaplan, Jeffrey W Meeusen, Leslie J Donato, Fernando G Cosio, D Eric Steidley
BACKGROUND: Solubility of Tumorigenicity 2 (sST2) is a novel biomarker that better stratifies risk of cardiovascular events (CVE) compared to cardiac troponin T(cTnT) in heart failure. We assessed the association of sST2 with the composite outcome of CVE and/or mortality compared to cTnT in kidney transplant candidates. METHODS: 200 kidney transplant candidates between 2010 and 2013 were included. Elevated sST2 was defined as ≥30ng/ml, cTnT≥0.01 ng/ml. RESULTS: Median age 53 (interquartile range (IQR) 42-61) years, 59...
2017: PloS One
https://www.readbyqxmd.com/read/28693485/three-members-of-medicago-truncatula-st-family-are-ubiquitous-during-development-and-modulated-by-nutritional-status-mtst1-and-dehydration-mtst2-and-mtst3
#7
Lucía Albornos, Ignacio Martín, Emilia Labrador, Berta Dopico
BACKGROUND: ShooT specific/Specific Tissue (ST) belong to a protein family of unknown function characterized by the DUF2775 domain and produced in specific taxonomic plant families, mainly Fabaceae and Asteraceae, with the Medicago truncatula ST family being the largest. The putative roles proposed for this family are cell elongation, biotic interactions, abiotic stress and N reserve. The aim of this work was to go deeper into the role of three M. truncatula ST proteins, namely ST1, ST2 and ST3...
July 10, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28691891/incidence-of-oxa-23-and-oxa-58-carbapenemases-coexpressed-in-clinical-isolates-of-acinetobacter-baumannii-in-tunisia
#8
Najla Mathlouthi, Yomna Ben Lamine, Rania Somai, Sophia Bouhalila-Besbes, Sofiane Bakour, Jean-Marc Rolain, Chedly Chouchani
Acinetobacter baumannii is an important opportunistic and multidrug-resistant pathogen responsible for nosocomial infections in health facilities. The aim of this study was to characterize the molecular mechanisms of carbapenem resistance in A. baumannii isolates isolated from Mohamed Kassab Orthopedic Institute in Tunis, Tunisia. Twenty-five imipenem-resistant A. baumannii clinical isolates collected between 2013 and 2016 were identified using API 20NE and were confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS)...
July 10, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28689068/efficient-induction-of-inner-ear-hair-cell-like-cells-from-mouse-es-cells-using-combination-of-math1-transfection-and-conditioned-medium-from-st2-stromal-cells
#9
Yukiteru Ouji, Masaharu Sakagami, Hiroko Omori, Shinji Higashiyama, Norikazu Kawai, Tadashi Kitahara, Akio Wanaka, Masahide Yoshikawa
We sought to establish a more efficient technique for induction of inner ear hair cell-like cells (HC-like cells) from embryonic stem cells (ES cells) by using a combination of two previously reported methods; ST2 stromal cell-conditioned medium, known to be favorable for HC-like cell induction (HIST2 method), and ES cells with transfer of the Math1 gene (Math1-ES cells). Math1-ES cells carrying Tet-inducible Math1 were cultured for 14days with doxycycline in conditioned medium from cultures of ST2 stromal cells following formation of 4-day embryoid bodies (EBs)...
July 1, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28687373/il-33-and-the-intestine-the-good-the-bad-and-the-inflammatory
#10
REVIEW
Zerina Hodzic, Ellen Merrick Schill, Alexa M Bolock, Misty Good
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been widely studied since its discovery in 2005 for its dichotomous functions in homeostasis and inflammation. IL-33, along with its receptor suppression of tumorigenicity 2 (ST2), has been shown to modulate both the innate and adaptive immune system. Originally, the IL-33/ST2 signaling axis was studied in the context of inducing type 2 immune responses with the expression of ST2 by T helper 2 (TH2) cells. However, the role of IL-33 is not limited to TH2 responses...
July 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28687251/associations-between-acute-gvhd-related-biomarkers-and-endothelial-cell-activation-after-allogeneic-hematopoietic-stem-cell-transplantation
#11
Shosaku Nomura, Kazuyoshi Ishii, Shinya Fujita, Aya Nakaya, Atsushi Satake, Tomoki Ito
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) can cause serious transplant-related complications such as graft-versus-host disease (GVHD). Acute GVHD (aGVHD) has been diagnosed by clinical manifestations, laboratory data and pathological effects until now, but recently the discovery of specific biomarkers such as suppression of tumorigenicity 2 (ST2), elafin and regenerating islet-derived 3α (REG3α) is challenging this approach. METHODS: We investigated the expression of aGVHD-related markers (regulated on activation normal T-cell expressed and secretes: RANTES, elafin, REG3α and ST2) and endothelial cell activation markers (soluble vascular cell adhesion molecule: sVCAM-1 and plasminogen activator inhibitor: PAI-1) in patients undergoing allogeneic HSCT...
July 4, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28683724/first-report-of-cavitary-pneumonia-due-to-community-acquired-acinetobacter-pittii-study-of-virulence-and-overview-of-pathogenesis-and-treatment
#12
Romaric Larcher, Alix Pantel, Erik Arnaud, Albert Sotto, Jean-Philippe Lavigne
BACKGROUND: Acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. We report for the first time that A. pittii can be responsible for cavitary community-acquired pneumonia and study its virulence, and discuss its pathogenesis and treatment options. CASE PRESENTATION: A 45-year-old woman with a history of smoking and systemic lupus was admitted to Nimes University Hospital (France) with coughing and sputum lasting for three weeks...
July 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28680750/il-33-restricts-tumor-growth-and-inhibits-pulmonary-metastasis-in-melanoma-bearing-mice-through-eosinophils
#13
Valeria Lucarini, Giovanna Ziccheddu, Iole Macchia, Valentina La Sorsa, Francesca Peschiaroli, Carla Buccione, Antonella Sistigu, Massimo Sanchez, Sara Andreone, Maria Teresa D'Urso, Massimo Spada, Daniele Macchia, Claudia Afferni, Fabrizio Mattei, Giovanna Schiavoni
The alarmin IL-33 is an IL-1 family member that stimulates pleiotropic immune reactions depending on the target tissue and microenvironmental factors. In this study, we have investigated the role of IL-33/ST2 axis in antitumor response to melanoma. Injection of IL-33 in mice-bearing subcutaneous B16.F10 melanoma resulted in significant tumor growth delay. This effect was associated with intratumoral accumulation of CD8(+) T cells and eosinophils, decrease of immunosuppressive myeloid cells, and a mixed Th1/Th2 cytokine expression pattern with local and systemic activation of CD8(+) T and NK cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28674969/blastocystis-in-c%C3%A3-te-d-ivoire-molecular-identification-and-epidemiological-data
#14
R D'Alfonso, M Santoro, D Essi, A Monsia, Y Kaboré, C Glé, D Di Cave, R P Sorge, V Di Cristanziano, F Berrilli
Blastocystis is an enteric protozoan infecting humans and animals in both developed and developing countries at all latitudes. Despite this, data on Blastocystis infection are not available for several geographical areas, including many African countries. In this study, a survey was conducted on Blastocystis among humans and domestic animals in rural and urban localities in Côte d'Ivoire, in order to investigate the prevalence, the subtype distribution, and the zoonotic potential in association with sociodemographic factors, seasonality, symptoms, and co-infections...
July 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28668506/interleukin-33-signaling-contributes-to-renal-fibrosis-following-ischemia-reperfusion
#15
Hua Liang, Feng Xu, Xian-Jie Wen, Hong-Zhen Liu, Han-Bing Wang, Ji-Ying Zhong, Cheng-Xiang Yang, Bin Zhang
Acute kidney injury caused by ischemia-reperfusion injury (IRI) is a major risk factor for chronic kidney disease, which is characterized by renal interstitial fibrosis. However, the molecular mechanisms underlying renal fibrosis induced by IRI are not fully understood. Our results showed that interleukin (IL)-33 was induced markedly after IRI insult, and the kidneys of mice following IRI plus IL-33 treatment presented more severe renal fibrosis compared with mice treated with IRI alone. Therefore, we investigated whether inhibition of IL-33 protects against IRI-induced renal fibrosis...
June 28, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28664478/the-integrated-value-of-sst2-and-global-longitudinal-strain-in-the-early-stratification-of-patients-with-severe-aortic-valve-stenosis-a-translational-imaging-approach
#16
Iacopo Fabiani, Lorenzo Conte, Nicola Riccardo Pugliese, Enrico Calogero, Valentina Barletta, Rossella Di Stefano, Tatiana Santoni, Cristian Scatena, Uberto Bortolotti, Antonio Giuseppe Naccarato, Anna Sonia Petronio, Vitantonio Di Bello
Aortic valve stenosis (AVS) is associated with significant myocardial fibrosis (MF). Global longitudinal strain (GLS) is a sensible indicator of systolic dysfunction. ST2 is a member of the interleukin (IL)-1 receptor family and a modulator of hypertrophic and fibrotic responses. We aimed at assessing: (a) the association between adverse LV remodeling, LV functional parameters (including GLS) and sST2 level. (b) The association between MF (detected by endo-myocardial biopsy) and sST2 in patients with AVS undergoing surgical valve replacement...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28656542/identifying-subpopulations-with-distinct-response-to-treatment-using-plasma-biomarkers-in-acute-heart-failure-results-from-the-protect-trial-differential-response-in-acute-heart-failure
#17
Licette C Y Liu, Mattia A E Valente, Douwe Postmus, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G F Cleland, Michael M Givertz, Daniel M Bloomfield, Dirk J van Veldhuisen, Hans L Hillege, Peter van der Meer, Adriaan A Voors
BACKGROUND: Over the last 50 years, clinical trials of novel interventions for acute heart failure (AHF) have, with few exceptions, been neutral or shown harm. We hypothesize that this might be related to a differential response to pharmacological therapy. METHODS: We studied the magnitude of treatment effect of rolofylline across clinical characteristics and plasma biomarkers in 2033 AHF patients and derived a biomarker-based responder sum score model. Treatment response was survival from all-cause mortality through day 180...
June 27, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28653113/association-of-soluble-st2-with-functional-capacity-in-outpatients-with-heart-failure
#18
O Yucel, I Gul, A Zararsiz, O Demirpence, H Yucel, Z Cinar, A Zorlu, M B Yilmaz
BACKGROUND: Biomarkers play an important role in the risk stratification of patients with heart failure (HF). Recent studies have shown that soluble suppression of tumorigenicity 2 (sST2), a member of the interleukin 1 receptor family, is associated with disease prognosis in acute and chronic HF. In this study we aimed to investigate the relation between sST2 level and functional capacity in outpatients with systolic HF. PATIENTS AND METHODS: This study included 120 HF patients with reduced ejection fraction (HFrEF; EF ≤ 40%)...
June 26, 2017: Herz
https://www.readbyqxmd.com/read/28651919/st2-predicts-survival-in-patients-undergoing-transcatheter-aortic-valve-implantation
#19
Johannes Schmid, Tatjana Stojakovic, David Zweiker, Hubert Scharnagl, Ralph D Maderthaner, Daniel Scherr, Robert Maier, Albrecht Schmidt, Winfried März, Josepha S Binder, Peter P Rainer
OBJECTIVE: To assess soluble suppression of tumorigenicity 2 (sST2) serum concentrations and predict mortality in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS: We prospectively enrolled 74 patients with severe aortic stenosis (AS) who underwent TAVI and matched them to patients without aortic valve disease (n=74). AS patients underwent comprehensive echocardiographic and cardiac magnetic resonance imaging and laboratory examinations...
June 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28641514/clinically-relevant-biomarkers-in-acute-heart-failure-an-update
#20
Agnibh Mukherji, Uzair Ansari, Martin Borggrefe, Ibrahim Akin, Michael Behnes
Acute heart failure (AHF) has been one of the fields, where owing to difficulties in diagnosis, prognostic stratification and management the associated morbidity and mortality remains unusually high. The advent of novel biomarkers apart from the traditional B-type natriuretic peptide and N-terminal proBNP involved in myocardial injury, neuro-hormonal activation, and ventricular remodeling augurs immense hope in redefining our approach towards AHF. METHODS: Biomarkers like midregional proatrial natriuretic peptide, soluble ST2, highly-sensitive troponin, and midregional proadrenomedullin are some such examples that have passed various stages of substantiation while there is an array of potential biomarkers in nascent stages like osteopontin, CTGF, GDF-15 and TGF beta-1 awaiting further reiteration...
June 22, 2017: Current Pharmaceutical Biotechnology
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