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https://www.readbyqxmd.com/read/28539516/memory-not-just-perception-plays-an-important-role-in-terrestrial-mammalian-migration
#1
Chloe Bracis, Thomas Mueller
One of the key questions regarding the underlying mechanisms of mammalian land migrations is how animals select where to go. Most studies assume perception of resources as the navigational mechanism. The possible role of memory that would allow forecasting conditions at distant locations and times based on information about environmental conditions from previous years has been little studied. We study migrating zebra in Botswana using an individual-based simulation model, where perceptually guided individuals use currently sensed resources at different perceptual ranges, while memory-guided individuals use long-term averages of past resources to forecast future conditions...
May 31, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28518221/micronutrient-supplementation-in-adults-with-hiv-infection
#2
REVIEW
Marianne E Visser, Solange Durao, David Sinclair, James H Irlam, Nandi Siegfried
BACKGROUND: Micronutrient deficiencies are common among adults living with HIV disease, particularly in low-income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. OBJECTIVES: To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV-related morbidity of HIV-positive adults (excluding pregnant women)...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28505328/advanced-hiv-disease-in-botswana-following-successful-antiretroviral-therapy-rollout-incidence-of-and-temporal-trends-in-cryptococcal-meningitis
#3
Mark W Tenforde, Margaret Mokomane, Tshepo Leeme, Raju K K Patel, Nametso Lekwape, Chandapiwa Ramodimoosi, Bonno Dube, Elizabeth A Williams, Kelebeletse O Mokobela, Ephraim Tawanana, Tlhagiso Pilatwe, William J Hurt, Hannah Mitchell, Doreen L Banda, Hunter Stone, Mooketsi Molefi, Kabelo Mokgacha, Heston Phillips, Paul C Mullan, Andrew P Steenhoff, Yohana Mashalla, Madisa Mine, Joseph N Jarvis
Background: Botswana has a well-developed antiretroviral therapy (ART) program which serves as a regional model. With wide ART availability, the burden of advanced HIV and associated opportunistic infections would be expected to decline. We performed a nationwide surveillance study to determine the national incidence of cryptococcal meningitis, and describe characteristics of cases 2000-2014 and temporal trends at two national referral hospitals. Methods: Cerebrospinal fluid data from all 37 laboratories performing meningitis diagnostics in Botswana were collected 2000-2014 to identify cases of cryptococcal meningitis...
May 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28497124/parv4-prevalence-phylogeny-immunology-and-coinfection-with-hiv-hbv-and-hcv-in-a-multicentre-african-cohort
#4
Colin P Sharp, William F Gregory, Louise Hattingh, Amna Malik, Emily Adland, Samantha Daniels, Anriette van Zyl, Jonathan M Carlson, Susan Wareing, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Thumbi Ndung'u, Philip J R Goulder, Paul Klenerman, Peter Simmonds, Pieter Jooste, Philippa C Matthews
Background: The seroprevalence of human parvovirus-4 (PARV4) varies considerably by region. In sub-Saharan Africa, seroprevalence is high in the general population, but little is known about the transmission routes or the prevalence of coinfection with blood-borne viruses, HBV, HCV and HIV.  Methods: To further explore the characteristics of PARV4 in this setting, with a particular focus on the prevalence and significance of coinfection, we screened a cohort of 695 individuals recruited from Durban and Kimberley (South Africa) and Gaborone (Botswana) for PARV4 IgG and DNA, as well as documenting HIV, HBV and HCV status...
April 7, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28491214/prescribing-pattern-of-psychotropic-medications-in-child-psychiatric-practice-in-a-mental-referral-hospital-in-botswana
#5
Anthony Olashore, James Ayugi, Philip Opondo
INTRODUCTION: There is a growing preference for psycho-pharmacological therapy over non-pharmacological care. The prescription pattern and the choice of psychotropic medications vary in different settings. Whilst newer agents and rational prescribing are favored in the more specialized settings, the pattern remains unclear in less specialized units, largely due to lack of data. The aims were to conduct a treatment audit in the only mental referral hospital in Botswana, which is a non-specialized child and adolescent care setting and see how it conforms to best practice...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28489856/randomized-trial-of-stopping-or-continuing-art-among-postpartum-women-with-pre-art-cd4-%C3%A2-400-cells-mm3
#6
Judith S Currier, Paula Britto, Risa M Hoffman, Sean Brummel, Gaerolwe Masheto, Esau Joao, Breno Santos, Linda Aurpibul, Marcelo Losso, Marie F Pierre, Adriana Weinberg, Devasena Gnanashanmugam, Nahida Chakhtoura, Karin Klingman, Renee Browning, Anne Coletti, Lynne Mofenson, David Shapiro, Jose Pilotto
BACKGROUND: Health benefits of postpartum antiretroviral therapy (ART) for human immunodeficiency virus (HIV) positive women with high CD4+ T-counts have not been assessed in randomized trials. METHODS: Asymptomatic, HIV-positive, non-breastfeeding women with pre-ART CD4+ T-cell counts ≥ 400 cells/mm3 started on ART during pregnancy were randomized up to 42 days after delivery to continue or discontinue ART. Lopinavir/ritonavir plus tenofovir/emtricitabine was the preferred ART regimen...
2017: PloS One
https://www.readbyqxmd.com/read/28486963/polypharmacy-among-children-and-adolescents-with-psychiatric-disorders-in-a-mental-referral-hospital-in-botswana
#7
Anthony A Olashore, Ambrose Rukewe
BACKGROUND: There is a dearth of data on polypharmacy in child and adolescent mental health in Africa, especially Botswana where children and adults are treated in the same facility by general adult psychiatrists. This study was therefore designed to assess the prevalence and the risk factors of psychiatric polypharmacy among children and adolescents treated at Sbrana Psychiatric Hospital, Lobatse, Botswana. METHODS: Data involving socio-demographics, diagnosis (using ICD-10 classification) and pharmacological treatment were retrieved from the records of 120 children and adolescents aged below 18 years, between 1 January 2012 and 31 July 2016, who presented with psychiatric disorders...
May 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28481785/cyp2b6-516g-t-minor-allele-protective-of-late-virologic-failure-in-efavirenz-treated-hiv-infected-patients-in-botswana
#8
Marijana Vujkovic, Scarlett L Bellamy, Athena F Zuppa, Marc Gastonguay, Ganesh S Moorthy, Bakgaki R Ratshaa, Xiaoyan Han, Andrew P Steenhoff, Mosepele Mosepele, Brian L Strom, Richard Aplenc, Gregory P Bisson, Robert Gross
BACKGROUND: CYPB2B6 polymorphisms that affect efavirenz (EFV) concentrations are common, but the effect of this polymorphism on HIV virologic failure in clinical practice settings has not fully been elucidated. Our objective was to investigate the relationship between the CYPB2B6 516G>T genotype and late virologic failure in patients treated with EFV in Gaborone, Botswana. SETTING: We performed a case-control study that included 1,338 HIV-infected black Batswana on EFV-based antiretroviral therapy (ART)...
May 5, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28472448/markers-of-gut-dysfunction-do-not-explain-low-rifampicin-bioavailability-in-hiv-associated-tb
#9
Christopher Vinnard, Shruthi Ravimohan, Neo Tamuhla, Jotam Pasipanodya, Shashikant Srivastava, Chawangwa Modongo, Nicola M Zetola, Drew Weissman, Tawanda Gumbo, Gregory P Bisson
Background: Rifampicin is the key drug responsible for sterilizing activities in the first-line TB treatment regimen. Damage to the gut during acute and chronic HIV infection may inhibit drug absorptive capacity. We sought to test the hypothesis that markers of intestinal damage, bacterial translocation and systemic immune activation would relate to rifampicin bioavailability among HIV/TB patients. Patients and methods: We conducted a prospective cohort study of rifampicin pharmacokinetics in HIV/TB patients in Gaborone, Botswana...
May 2, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28419352/dermatophytes-and-dermatophytosis-in-the-eastern-and-southern-parts-of-africa
#10
E I Nweze, I E Eke
Dermatophytosis is currently a disease of global importance and a public health burden. It is caused by dermatophytes, which attack and grow on dead animal keratin. Dermatophytes belong to three genera, namely, Epidermophyton, Microsporum, and Trichophyton. The predominant clinical forms and causative agents vary from one region of the world to another. Poor socioeconomic status, high population densities, and poor sanitary conditions are some of the factors responsible for the high prevalence of dermatophytosis in many developing countries, which include countries in southern and eastern Africa, the focus of this review...
April 17, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28414757/predictors-of-smoking-among-primary-and-secondary-school-students-in-botswana
#11
Bontle Mbongwe, Roy Tapera, Nthabiseng Phaladze, Andrew Lord, Nicola M Zetola
This study seeks to determine the prevalence and risk factors for smoking among students aged 12-18 years in two cities in Botswana. Using a sample of 2554 students we adapted the Global Youth Tobacco Survey (GYTS) methodology to assess students' smoking practices, knowledge, beliefs and attitudes. Logistic regression models were used to evaluate factors associated with smoking. The results revealed that 10% of students were current tobacco smokers with 29% reporting having tried smoking. Self-image and acceptance by peers were the strongest predictors of smoking overall (adjusted Odds Ratio [aOR]: 3...
2017: PloS One
https://www.readbyqxmd.com/read/28406033/the-impact-of-hiv-antiretroviral-treatment-perception-on-risky-sexual-behaviour-in-botswana-a-short-report
#12
Gobopamang Letamo, Mpho Keetile, Kannan Navaneetham
The aim of this article is to investigate the impact of ART perception on risky sexual behaviours in Botswana. Using binary logistic regression analysis controlling for individual characteristics, the results tend to support the hypothesis that ART misconceptions do not necessarily increase risky sexual behaviours. In particular, the study findings suggest the belief that ARVs cure HIV and AIDS and that people on ARVs should not always use condoms do not necessarily lead to increased risky sexual behaviours, particularly among women...
April 13, 2017: AIDS Care
https://www.readbyqxmd.com/read/28399975/survey-of-health-care-worker-knowledge-about-childhood-tuberculosis-in-high-burden-centers-in-botswana
#13
T Arscott-Mills, L Masole, R Ncube, A P Steenhoff
BACKGROUND: Quantifying health care workers' (HCWs') knowledge about tuberculosis (TB) informs educational interventions. We assessed HCWs' knowledge about childhood TB in Botswana. METHODS: Semi-structured interviews were conducted with HCWs at 46 sites around Botswana using a piloted instrument. Transcripts were double-coded using a coding schema. Discrepancies were resolved by consensus and a systematic thematic analysis was performed. RESULTS: The sites (42 clinics and 4 hospitals) were urban (n = 9, 20%), semi-urban (n = 10, 22%) and rural (n = 27, 58%)...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399056/the-nasopharyngeal-microbiota-of-children-with-respiratory-infections-in-botswana
#14
Matthew S Kelly, Michael G Surette, Marek Smieja, Jeffrey M Pernica, Laura Rossi, Kathy Luinstra, Andrew P Steenhoff, Kristen A Feemster, David M Goldfarb, Tonya Arscott-Mills, Sefelani Boiditswe, Ikanyeng Rulaganyang, Charles Muthoga, Letang Gaofiwe, Tiny Mazhani, John F Rawls, Coleen K Cunningham, Samir S Shah, Patrick C Seed
BACKGROUND: Nearly half of child pneumonia deaths occur in sub-Saharan Africa. Microbial communities in the nasopharynx are a reservoir for pneumonia pathogens and remain poorly described in African children. METHODS: Nasopharyngeal swabs were collected from children with pneumonia (N=204), children with upper respiratory infection symptoms (N=55), and healthy children (N=60) in Botswana between April 2012 and April 2014. We sequenced the V3 region of the bacterial 16S ribosomal RNA gene and used partitioning around medoids to cluster samples into microbiota biotypes...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28395844/effect-of-co-trimoxazole-on-mortality-in-hiv-exposed-but-uninfected-children-in-botswana-the-mpepu-study-a-double-blind-randomised-placebo-controlled-trial
#15
Shahin Lockman, Michael Hughes, Kate Powis, Gbolahan Ajibola, Kara Bennett, Sikhulile Moyo, Erik van Widenfelt, Jean Leidner, Kenneth McIntosh, Loeto Mazhani, Joseph Makhema, Max Essex, Roger Shapiro
BACKGROUND: Co-trimoxazole prophylaxis reduces mortality among HIV-infected children, but efficacy in HIV-exposed but uninfected (HEU) children in a non-malarial, low-breastfeeding setting with a low risk of mother-to-child transmission of HIV is unclear. METHODS: HEU children in Botswana were randomly assigned to receive co-trimoxazole (100 mg/20 mg once daily until age 6 months and 200 mg/40 mg once daily thereafter) or placebo from age 14-34 days to age 15 months...
May 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28383545/the-collaborative-african-genomics-network-training-program-a-trainee-perspective-on-training-the-next-generation-of-african-scientists
#16
Busisiwe C Mlotshwa, Savannah Mwesigwa, Gerald Mboowa, Lesedi Williams, Gaone Retshabile, Adeodata Kekitiinwa, Misaki Wayengera, Samuel Kyobe, Chester W Brown, Neil A Hanchard, Graeme Mardon, Moses Joloba, Gabriel Anabwani, Sununguko W Mpoloka
PURPOSE: The Collaborative African Genomics Network (CAfGEN) aims to establish sustainable genomics research programs in Botswana and Uganda through long-term training of PhD students from these countries at Baylor College of Medicine. Here, we present an overview of the CAfGEN PhD training program alongside trainees' perspectives on their involvement. BACKGROUND: Historically, collaborations between high-income countries (HICs) and low- and middle-income countries (LMICs), or North-South collaborations, have been criticized for the lack of a mutually beneficial distribution of resources and research findings, often undermining LMICs...
April 6, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28369309/analysis-of-false-negative-hiv-rapid-tests-performed-on-oral-fluid-in-three-international-clinical-research-studies
#17
Marcel E Curlin, Roman Gvetadze, Wanna Leelawiwat, Michael Martin, Charles Rose, Richard W Niska, Tebogo M Segolodi, Kachit Choopanya, Jaray Tongtoyai, Timothy H Holtz, Taraz Samandari, Janet M Mcnicholl
Objective: The OraQuick Advance Rapid HIV-1/2 Test is a point-of-care test capable of detecting HIV-specific antibodies in blood and oral fluid. To understand test performance and factors contributing to false-negative (FN) results in longitudinal studies, we examined results of participants enrolled in the TDF2 study, the Bangkok Tenofovir Study, and the Bangkok MSM Cohort Study (BMCS), three separate clinical studies of high-risk, HIV-negative persons conducted in Botswana and Thailand...
March 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28363511/risk-factors-for-malnutrition-among-children-with-cerebral-palsy-in-botswana
#18
Allison Johnson, Claudia Gambrah-Sampaney, Esha Khurana, James Baier, Esther Baranov, Baphaleng Monokwane, David R Bearden
BACKGROUND: Children with cerebral palsy in low-resource settings are at high risk of malnutrition, which further increases their risk of poor health outcomes. However, there are few available data on specific risk factors for malnutrition among children with cerebral palsy in the developing world. METHODS: We performed a case-control study among children with cerebral palsy receiving care at a tertiary care hospital in Gaborone, Botswana. Children with cerebral palsy and malnutrition were identified according to World Health Organization growth curves and compared with subjects with cerebral palsy without malnutrition...
February 14, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28350554/high-sensitivity-and-specificity-of-the-cepheid-xpert%C3%A2-hiv-1-qualitative-point-of-care-test-among-newborns-in-botswana
#19
Maryanne Ibrahim, Sikhulile Moyo, Terence Mohammed, Lucy Mupfumi, Simani Gaseitsiwe, Kenneth Maswabi, Gbolahan Ajibola, Rebecca Gelman, Oganne Batlang, Maureen Sakoi, Chloe Auletta-Young, Joseph Makhema, Shahin Lockman, Roger L Shapiro
BACKGROUND: HIV point-of-care (POC) testing allows for early infant HIV diagnosis and treatment, but POC accuracy at birth and in the setting of antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission (MTCT) is unknown. METHODS: We evaluated the Cepheid Xpert® HIV-1 Qual POC test against the Roche Taqman HIV-1 PCR platform using dried blood spots from 15 HIV-infected and 75 HIV-exposed uninfected newborns. These infants were screened for HIV at <96 hours of life at 5 hospital maternity wards in Botswana; all infants received post-exposure antiretroviral prophylaxis (PEP) and most mothers received 3-drug antiretroviral therapy in pregnancy and at delivery...
March 24, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28339500/detecting-congenital-malformations-lessons-learned-from-the-mpepu-study-botswana
#20
Gbolahan Ajibola, Rebecca Zash, Roger L Shapiro, Oganne Batlang, Kerapetse Botebele, Kara Bennett, Florence Chilisa, Erik von Widenfelt, Joseph Makhema, Shahin Lockman, Lewis B Holmes, Kathleen M Powis
INTRODUCTION: A large and increasing number of HIV-infected women are conceiving on antiretroviral treatment (ART). While most antiretrovirals are considered safe in pregnancy, monitoring for rare pregnancy and infant adverse outcomes is warranted. METHODS: We conducted a retrospective secondary analysis nested within a clinical trial of infant cotrimoxazole vs. placebo prophylaxis in Botswana (the Mpepu Study). Infants were examined at birth, and at least every 3 months through 18 months of age...
2017: PloS One
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