keyword
MENU ▼
Read by QxMD icon Read
search

Botswana

keyword
https://www.readbyqxmd.com/read/29772814/chronic-and-occult-hepatitis-b-virus-infection-in-pregnant-women-in-botswana
#1
Tshepiso Mbangiwa, Ishmael Kasvosve, Motswedi Anderson, Prisca K Thami, Wonderful T Choga, Austen Needleman, Bonolo B Phinius, Sikhulile Moyo, Melvin Leteane, Jean Leidner, Jason T Blackard, Gloria Mayondi, Betsy Kammerer, Rosemary M Musonda, Max Essex, Shahin Lockman, Simani Gaseitsiwe
The hepatitis B virus (HBV) is a global problem; however, the burden of HBV infection in pregnant women in Botswana is unknown. We sought to determine the prevalence of chronic and occult HBV infection in human immunodeficiency virus (HIV)-infected and -uninfected pregnant women in Botswana. Samples from 752 pregnant women were tested for hepatitis B surface antigen (HBsAg), and HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) and HBV DNA load. Samples that were HBsAg negative were screened for occult HBV infection by determining the HBV DNA load...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29772280/an-analysis-of-palliative-care-development-in-africa-a-ranking-based-on-region-specific-macro-indicators
#2
John Y Rhee, Eduardo Garralda, Eve Namisango, Emmanuel Luyirika, Liliana de Lima, Richard A Powell, Jesús López-Fidalgo, Carlos Centeno
CONTEXT: To date, there is no study comparing palliative care (PC) development among African countries. OBJECTIVE: To analyze comparatively PC development in African countries based on region-specific indicators. METHODS: Data were obtained from the APCA Atlas of PC in Africa and a comparative analysis conducted. Nineteen indicators were developed and defined through qualitative interviews with African PC experts and a two-round modified Delphi consensus process with international experts on global PC indicators...
May 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29771781/lack-of-virological-suppression-among-young-hiv-positive-adults-in-botswana
#3
Vlad Novitsky, Tendani Gaolathe, Mompati Mmalane, Sikhulile Moyo, Unoda Chakalisa, Etienne Kadima Yankinda, Tafireyi Marukutira, Molly Pretorius Holme, Tumalano Sekoto, Simani Gaseitsiwe, Rosemary Musonda, Erik van Widenfelt, Kathleen M Powis, Nealia Khan, Scott Dryden-Peterson, Kara Bennett, Kathleen E Wirth, Eric Tchetgen Tchetgen, Pam Bachanas, Lisa A Mills, Refeletswe Lebelonyane, El-Halabi Shenaaz, Joseph Makhema, Shahin Lockman, M Essex
BACKGROUND: HIV-1 RNA load is the best biological predictor of HIV transmission and treatment response. The rate of virologic suppression among key sub-populations can guide HIV prevention programs. METHODS: The Botswana Combination Prevention Project performed a population-based household survey among adults in 30 communities in Botswana. Data collected included knowledge of HIV-positive status, ART coverage and virologic suppression (HIV-1 RNA ≤400 copies/mL)...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771268/hiv-disease-is-associated-with-increased-biomarkers-of-endothelial-dysfunction-despite-viral-suppression-on-long-term-antiretroviral-therapy-in-botswana
#4
Mosepele Mosepele, Terence Mohammed, Lucy Mupfumi, Sikhulile Moyo, Kara Bennett, Shahin Lockman, Linda C Hemphill, Virginia A Triant
BACKGROUND: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial dysfunction among virally suppressed HIV-infected adults on long-term antiretroviral therapy (ART) have not been well studied in sub-Saharan Africa (SSA). METHODS: We enrolled 112 HIV-infected adults with virological suppression on long-term ART and 84 HIV-uninfected controls in Botswana. We measured plasma levels of markers of endothelial injury [soluble vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and E-selectin] and plasma levels of biomarkers of inflammation [interleukin 6 (IL-6)] and monocyte activation (sCD163)...
May 14, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29762166/undisclosed-antiretroviral-drug-use-in-botswana-implication-for-national-estimates
#5
Sikhulile Moyo, Simani Gaseitsiwe, Kathleen M Powis, Molly Pretorius Holme, Terence Mohammed, Melissa Zahralban-Steele, Etienne K Yankinde, Comfort Maphorisa, William Abrams, Refeletswe Lebelonyane, Kutlo Manyake, Tumalano Sekoto, Mompati Mmalane, Tendani Gaolathe, Kathleen E Wirth, Joseph Makhema, Shahin Lockman, William Clarke, Max Essex, Vlad Novitsky
: Among 3596 HIV-positive participants enrolled in Botswana Combination Prevention Project who self-reported no prior antiretroviral (ARV) therapy use and were tested for viral load (n = 951; 27% of all participants), 136 (14%) had HIV-1 RNA less than 400 copies/ml. ARV drugs were detected in 52 (39%) of 134 participants tested. Adjusting for undisclosed ARV use increased the overall estimate of virally suppressed individuals on ARV therapy by 1.4% from 70.2 to 71.6%.
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29761140/hearing-impairment-among-children-referred-to-a-public-audiology-clinic-in-gaborone-botswana
#6
Francis M Banda, Kathleen M Powis, Agnes B Mokoka, Moalosi Mmapetla, Katherine D Westmoreland, Thuso David, Andrew P Steenhoff
Objective . To describe and quantify hearing impairment among children referred to the audiology clinic in Princess Marina Hospital, a public referral hospital in Botswana. Methods . In a retrospective case series, we reviewed medical records of children aged 10 years and younger whose hearing was assessed between January 2006 and December 2015 at the audiology clinic of Princess Marina Hospital in Gaborone, Botswana. Results . Of 622 children, 50% were male, and median age was 6.7 years (interquartile range = 5...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29760356/the-impact-of-parental-migration-on-injuries-among-left-behind-young-people-aged-10-years-to-24-years-in-botswana
#7
Lesego Selotlegeng
There has been little evidence of the relationship between children and absence of parents in Botswana literature; and it is still the case that absence of parents increases the risk of injuries to their children. The aim of this study is to investigate the impact of parental migration among left behind young people aged 10 years to 24 years in Botswana and examine patterns of injuries from immigrant families. This is a population-based crosssection from which a dataset was created by compiling data from two different sources for the period of 2010 to 2015...
2018: Bioscience Trends
https://www.readbyqxmd.com/read/29751808/physical-violence-against-health-staff-by-mentally-ill-patients-at-a-psychiatric-hospital-in-botswana
#8
Anthony A Olashore, Oluyemi O Akanni, Radiance M Ogundipe
BACKGROUND: Workplace violence is worrisome in the mental health sector. Little is understood about it in sub-Saharan Africa. Consequently, we decided to investigate the prevalence, related factors, and the available sources of support for the victims of workplace violence in a mental referral hospital in Botswana. METHODS: We conducted a cross-sectional retrospective survey of 201 mental health staff (MHS) of Sbrana Psychiatric Hospital, Botswana. We used a self-administered questionnaire to obtain information on socio-demographics and various aspects of work-related violence and available source of supports...
May 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29736242/association-with-humans-and-seasonality-interact-to-reverse-predictions-for-animal-space-use
#9
Peter N Laver, Kathleen A Alexander
Background: Variation in animal space use reflects fitness trade-offs associated with ecological constraints. Associated theories such as the metabolic theory of ecology and the resource dispersion hypothesis generate predictions about what drives variation in animal space use. But, metabolic theory is usually tested in macro-ecological studies and is seldom invoked explicitly in within-species studies. Full evaluation of the resource dispersion hypothesis requires testing in more species...
2018: Movement Ecology
https://www.readbyqxmd.com/read/29735343/home-ranges-of-lions-in-the-kalahari-botswana-exhibit-vast-sizes-and-high-temporal-variability
#10
André Zehnder, Stephen Henley, Robert Weibel
The central Kalahari region in Botswana is one of the few remaining ecosystems with a stable lion population. Yet, relatively little is known about the ecology of the lions there. As an entry point, home range estimations provide information about the space utilization of the studied animals. The home ranges of eight lions in this region were determined to investigate their spatial overlaps and spatiotemporal variations. We found that, except for MCP, all home range estimators yielded comparable results regarding size and shape...
April 9, 2018: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29732907/prevalence-of-rilpivirine-and-etravirine-resistance-mutations-in-hiv-1-subtype-c-infected-patients-failing-nevirapine-or-efavirenz-based-combination-antiretroviral-therapy-in-botswana
#11
Thabo Diphoko, Simani Gaseitsiwe, Ishmael Kasvosve, Sikhulile Moyo, Harriet Okatch, Rosemary Musonda, Mark A Wainberg, Joseph Makhema, Richard Marlink, Vladimir Novitsky, M Essex
BACKGROUND: Rilpivirine (RPV) and Etravirine (ETR) are approved second-generation non-nucleoside reverse transcriptase inhibitors (NNRTI) for HIV treatment. There is a cross-resistance HIV mutation profile between first- and second-generation NNRTI drugs. We determined the prevalence of HIV-1drug-resistance mutations (DRM) to RPV and ETR in Botswana. METHODS: A total of 168 HIV-1 polymerase gene sequences from participants failing nevirapine or efavirenz-containing regimens were analysed for drug resistance mutations using the Stanford University HIV drug resistance database...
May 6, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29732382/common-variation-in-nlrp3-is-associated-with-early-death-and-elevated-inflammasome-biomarkers-among-advanced-hiv-tb-co-infected-patients-in-botswana
#12
Shruthi Ravimohan, Kebatshabile Nfanyana, Neo Tamuhla, Caroline T Tiemessen, Drew Weissman, Gregory P Bisson
Background: Elevated inflammation is associated with early mortality among HIV/tuberculosis (TB) patients starting antiretroviral therapy (ART); however, the sources of immune activation are unclear. We hypothesized that common variation in innate immune genes contributes to excessive inflammation linked to death. As single nucleotide polymorphisms (SNPs) in inflammasome pathway genes can increase risk for inflammatory diseases, we investigated their association with early mortality among a previously described cohort of HIV/TB patients initiating ART in Botswana...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29713595/did-microbial-larviciding-contribute-to-a-reduction-in-malaria-cases-in-eastern-botswana-in-2012-2013
#13
M Obopile, G Segoea, K Waniwa, D S Ntebela, K Moakofhi, M Motlaleng, T Mosweunyane, J K Edwards, J Namboze, W Butt, M Manzi, K C Takarinda, P Owiti
Setting: Larviciding has potential as a component of integrated vector management for the reduction of malaria transmission in Botswana by complementing long-lasting insecticide nets and indoor residual sprays. Objective: To evaluate the susceptibility of local Anopheles to commonly used larvicides. Design: This field test of the efficacy of Bacillus thuringiensis subsp. israliensis vs. Anopheles was performed by measuring larval density before treatment and 24 h and 48 h after treatment in seven sites of Bobirwa district, eastern Botswana, in 2012 and 2013...
April 25, 2018: Public Health Action
https://www.readbyqxmd.com/read/29713592/advances-in-malaria-elimination-in-botswana-a-dramatic-shift-to-parasitological-diagnosis-2008-2014
#14
K Moakofhi, J K Edwards, M Motlaleng, J Namboze, W Butt, M Obopile, T Mosweunyane, M Manzi, K C Takarinda, P Owiti
Background: Malaria elimination requires infection detection using quality assured diagnostics and appropriate treatment regimens. Although Botswana is moving towards malaria elimination, reports of unconfirmed cases may jeopardise this effort. This study aimed to determine the proportion of cases treated for malaria that were confirmed by rapid diagnostic testing (RDT) and/or microscopy. Methods: This was a retrospective descriptive study using routine national data from the integrated disease surveillance and case-based surveillance systems from 2008 to 2014...
April 25, 2018: Public Health Action
https://www.readbyqxmd.com/read/29713590/driving-towards-malaria-elimination-in-botswana-by-2018-progress-on-case-based-surveillance-2013-2014
#15
M Motlaleng, J Edwards, J Namboze, W Butt, K Moakofhi, M Obopile, M Manzi, K C Takarinda, R Zachariah, P Owiti, N Oumer, T Mosweunyane
Background: Reliable information reporting systems ensure that all malaria cases are tested, treated and tracked to avoid further transmission. Botswana aimed to eliminate malaria by 2018, and surveillance is key. This study focused on assessing the uptake of the new malaria case-based surveillance (CBS) system introduced in 2012, which captures information on malaria cases reported in the Integrated Disease Surveillance and Response (IDSR) system. Methods: This was a retrospective descriptive study based on routine data focusing on Ngami, Chobe and Okavango, three high-risk districts in Botswana...
April 25, 2018: Public Health Action
https://www.readbyqxmd.com/read/29707518/lessons-from-the-pilot-of-a-mobile-application-to-map-assistive-technology-suppliers-in-africa
#16
Surona J Visagie, Rebecca Matter, George M Kayange, Mussa Chiwaula, Mark Harniss, Gubela Mji, Elsje Scheffler
A pilot project to develop and implement a mobile smartphone application (App) that tracks and maps assistive technology (AT) availability in southern Africa was launched in Botswana in 2016. The App was developed and tested through an iterative process. The concept of the App (AT-Info-Map) was well received by most stakeholders within the pilot country, and broader networks. Several technical and logistical obstacles were encountered. These included high data costs; difficulty in accessing AT information from the public healthcare sector, the largest supplier of AT; and the high human resource demand of collecting and keeping up-to-date device-level information within a complex and fragmented supply sector that spans private, public and civil society entities...
2018: African Journal of Disability
https://www.readbyqxmd.com/read/29707385/similar-hiv-protection-from-four-weeks-of-zidovudine-versus-nevirapine-prophylaxis-among-formula-fed-infants-in-botswana
#17
Kathleen M Powis, Shahin Lockman, Gbolahan Ajibola, Michael D Hughes, Kara Bennett, Jean Leidner, Oganne Batlang, Kerapetse Botebele, Sikhulile Moyo, Erik van Widenfelt, Joseph Makhema, Chipo Petlo, Haruna B Jibril, Kenneth McIntosh, Max Essex, Roger L Shapiro
Background: The World Health Organization HIV guidelines recommend either infant zidovudine (ZDV) or nevirapine (NVP) prophylaxis for the prevention of intrapartum mother-to-child HIV transmission (MTCT) among formula-fed infants. No study has evaluated the comparative efficacy of infant prophylaxis with twice daily ZDV versus once daily NVP in exclusively formula-fed HIV-exposed infants. Methods: Using data from the Mpepu Study, a Botswana-based clinical trial investigating whether prophylactic co-trimoxazole could improve infant survival, retrospective analyses of MTCT events and Division of AIDS (DAIDS) Grade 3 or Grade 4 occurrences of anaemia or neutropenia were performed among infants born full-term (≥ 37 weeks gestation), with a birth weight ≥ 2500 g and who were formula-fed from birth...
2018: Southern African Journal of HIV Medicine
https://www.readbyqxmd.com/read/29706352/whole-exome-sequencing-reveals-uncaptured-variation-and-distinct-ancestry-in-the-southern-african-population-of-botswana
#18
Gaone Retshabile, Busisiwe C Mlotshwa, Lesedi Williams, Savannah Mwesigwa, Gerald Mboowa, Zhuoyi Huang, Navin Rustagi, Shanker Swaminathan, Eric Katagirya, Samuel Kyobe, Misaki Wayengera, Grace P Kisitu, David P Kateete, Eddie M Wampande, Koketso Maplanka, Ishmael Kasvosve, Edward D Pettitt, Mogomotsi Matshaba, Betty Nsangi, Marape Marape, Masego Tsimako-Johnstone, Chester W Brown, Fuli Yu, Adeodata Kekitiinwa, Moses Joloba, Sununguko W Mpoloka, Graeme Mardon, Gabriel Anabwani, Neil A Hanchard
Large-scale, population-based genomic studies have provided a context for modern medical genetics. Among such studies, however, African populations have remained relatively underrepresented. The breadth of genetic diversity across the African continent argues for an exploration of local genomic context to facilitate burgeoning disease mapping studies in Africa. We sought to characterize genetic variation and to assess population substructure within a cohort of HIV-positive children from Botswana-a Southern African country that is regionally underrepresented in genomic databases...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29700731/cross-sectional-prevalence-of-fasciola-gigantica-infections-in-beef-cattle-in-botswana
#19
M Ernest Mochankana, Ian D Robertson
A cross-sectional study was carried out to determine the prevalence and distribution of Fasciola gigantica infections in communally grazed and ranch-grazed beef cattle through coprological examination. A total of 8646 cattle (4618 adults, 2843 weaners and 1185 calves) faecal samples were collected during the 24 months of study. Results from this study indicated that only 64 (0.74%; 95% CI 0.57, 0.94%) of the samples were positive for F. gigantica eggs. The positive samples were detected in one (Central) of the six study districts and was restricted to the Tuli Block (commercial) farms in Machaneng village in eastern Botswana...
April 26, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29695878/taking-up-africa-s-cancer-challenge
#20
(no author information available yet)
Botswana, Kenya and Rwanda have started to provide cancer care in their national efforts to achieve universal coverage of health services. Tatum Anderson reports.
April 1, 2018: Bulletin of the World Health Organization
keyword
keyword
26013
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"