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https://www.readbyqxmd.com/read/29668145/-lost-in-transition-crossed-looks-on-the-18-25-years-old
#1
Sarah Depallens, Yusuke Leo Takeuchi, Katherine Roberts
Social determinants have an impact on patients' access to care and on their health at any age. Young adults are a population at risk of being affected in their health because of a lack of social protection or unavailability of healthcare system adapted to their specific needs. Primary healthcare providers need to identify that window of social vulnerability in order to avoid a discontinuation in healthcare and to prevent biopsychosocial co-morbidity leading to ongoing consequences on their health.
April 18, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29668129/-tuberculosis-in-the-era-of-anti-tnf-alpha-therapy-why-does-the-risk-still-exist
#2
John-Leonardo Torres-Castiblanco, Jorge Alberto Carrillo, Daniel Hincapié-Urrego, Adriana Rojas-Villarraga
Rheumatoid arthritis is an autoimmune systemic disease characterized mainly by inflammatory compromise of diarthrodial joints. Multiple drug therapies have been developed to control the activity of rheumatoid arthritis, among them, the first line of disease-modifying antirheumatic drugs (DMARD), and novel drug therapies such as the anti-TNF alpha therapy, with satisfactory clinical outcomes.Despite this positive fact, the use of this therapy implies the risk of producing negative effects due to its mechanism of action, which has been associated with multiple infections, especially tuberculosis, making it necessary to use screen tests before resorting to this kind of drugs...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668117/development-of-molecular-therapies-for-venous-malformations
#3
Jaakko Kangas, Marjut Nätynki, Lauri Eklund
Vascular anomalies are localized defects of morphogenesis that can affect lymphatic and blood vessels. They are generally called birthmarks, typically observed soon after birth and occurring in up to 10% of children. Based on their clinical and histological characteristics, they are classified into vascular tumours and vascular malformations. The most common malformations are venous malformations (VMs) resulting in chronic vascular diseases that can be associated with significant morbidity necessitating often demanding and repeating clinical management...
April 18, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29668044/impairments-in-hemodynamic-responses-to-orthostasis-associated-with-frailty-results-from-the-irish-longitudinal-study-on-ageing-tilda
#4
Matthew Dl O'Connell, George M Savva, Ciarán Finucane, Roman Romero-Ortuno, Chie Wei Fan, Rose Anne Kenny
OBJECTIVES: To characterize the relationships between orthostatic blood pressure (BP) and heart rate recovery and frailty in an older population. DESIGN: Cross-sectional study. SETTING: Two health centers in the Republic of Ireland. PARTICIPANTS: The Irish Longitudinal Study on Ageing participants aged 50 and older (N=4,334). MEASUREMENTS: Continuous noninvasive BP responses during active standing were captured using digital photoplethysmography...
April 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29668023/common-queries-about-immunizations-in-preterm-infants
#5
Ansul Asad
Preterm infants are at an increased risk of morbidity and mortality from vaccine-preventable diseases. Despite this, delays in routine immunization of preterm infants are common. Available guidelines clearly state that they should be immunized according to chronological age, irrespective of gestational age and birth weight or current weight. In this article, we try to assuage parental and provider doubts by reviewing data about immunogenicity, safety, and responses to routine immunizations in preterm infants with and without comorbidities...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#6
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29667916/fiscal-impact-of-smoking-cessation-in-thailand-a-government-perspective-cost-benefit-analysis
#7
Mark P Connolly, Nikolaos Kotsopoulos, Pichaya Suthipinijtham, Suthat Rungruanghiranya
We evaluate the broader public economic consequences of investments in smoking cessation that change lifetime productivity, which can influence future government tax revenue and social transfer costs and health care spending. The analysis applies a government perspective framework for assessing the intergenerational relationships between morbidity and mortality and lifetime tax revenue and social transfers received. Applying smoking prevalence in Thailand, a cohort model was developed for smoker and former smokers to estimate impact on lifetime direct taxes and tobacco taxes paid...
April 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29667794/body-dysmorphic-disorder-in-the-cosmetic-practice
#8
Helena Kuhn, Paulo R Cunha, Natalie H Matthews, George Kroumpouzos
Body dysmorphic disorder (BDD) is a preoccupation with a slight or imagined flaw in appearance that causes significant distress and impairment in daily functioning. The disease is more prevalent among patients who seek aesthetic procedures as compared with population standards or individuals that are not interested in aesthetic surgery. Several studies have indicated that BDD symptoms typically worsen after an aesthetic procedure because the preoccupation shifts to a different body area. This article discusses the demographic and clinical features, psychiatric comorbidity, assessment, differential diagnosis, and management of BDD...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667721/diverse-manifestations-of-acute-sickle-cell-hepatopathy-in-pediatric-patients-with-sickle-cell-disease-a-case-series
#9
Lydia H Pecker, Nidhi Patel, Susan Creary, Anil Darbari, Emily Riehm Meier, Deepika S Darbari, Ross M Fasano
The hepatic complications of sickle cell disease (SCD) are associated with increased morbidity and mortality in adults; children usually survive but may suffer significant sequelae. Few diagnostic tools differentiate the various hepatic manifestations of SCD. Why patients exhibit one hepatic pathology versus another is unclear. We report four pediatric patients with hemoglobin SS disease with diverse manifestations of acute hepatic involvement including acute sickle hepatic crisis, hepatic sequestration, sickle cell intrahepatic cholestasis, and a non-SCD cause of hepatopathy in a patient with viral hepatitis...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29667709/the-outlet-patch-gastric-heterotopia-of-the-colo-rectum-and-anus
#10
Abul Ala Syed Rifat Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam-Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth Montgomery
AIMS: Gastric heterotopia (GH) has been described throughout the gastrointestinal tract. However, the colorectal region is an extremely rare location for it. We describe the clinicopathologic features of GH of the colon, rectum, and anus. METHODS AND RESULTS: We identified 33 cases in 20 males and 13 females (median age 54 years; range, 4 months to 73 years). Sites included the rectum (N=26), anus (N=4), ileocecal junction (N=1), ascending colon (N=1) and descending colon (N=1)...
April 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29667577/people-living-with-undiagnosed-hiv-infection-and-a-low-cd4-count-estimates-from-surveillance-data-italy-2012-to-2014
#11
Vincenza Regine, Maria Dorrucci, Patrizio Pezzotti, Alessia Mammone, Chantal Quinten, Anastasia Pharris, Barbara Suligoi, The Regional Representatives Of The National Hiv Surveillance System
Background and aimsLate HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 -2014 were obtained from the national HIV surveillance system...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29667439/what-is-the-impact-of-the-2017-cochrane-systematic-review-and-meta-analysis-that-evaluated-the-use-of-pcsk9-inhibitors-for-lowering-cardiovascular-disease-and-mortality
#12
Mohamed A Jalloh, Eric J Ip, Shadi Doroudgar
In 2017, Schmidt et al. conducted a Cochrane systematic review and meta-analysis to evaluate the effect of using proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors to reduce low-density-lipoprotein- cholesterol (LDL-C) and cardiovascular disease (CVD). The Cochrane review was a systematic review and meta-analysis of 20 randomized, double-blinded trials that compared the use of PCSK9 inhibitors with statins/ezetimibe, ezetimibe, or placebo for a treatment duration of at least 24 weeks. The use of PCSK9 inhibitors lowered the risk for CVD (OR 0...
April 18, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29667417/review-of-duodenal-perforations-after-endoscopic-retrograde-cholangiopancreatography-in-hospital-puerta-de-hierro-from-1999-to-2014
#13
Elena Jiménez Cubedo, Javier López Monclús, José Luis Lucena de la Poza, Natalia González Alcolea, Pablo Calvo Espino, Arturo García Pavia, Victor Sánchez Turrión
INTRODUCTION: endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard in biliary and pancreatic pathology. Although the procedure has a significant morbidity and mortality rate. Algorithms are needed for the management and treatment of the associated complications. OBJECTIVE: to review the post-ERCP perforations treated in the Department of General Surgery of the Hospital Puerta de Hierro from 1999 to 2014. The results were evaluated according to the types of perforation and treatment...
April 18, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29667349/asb1-differential-methylation-in-ischaemic-cardiomyopathy-relationship-with-left-ventricular-performance-in-end-stage-heart-failure-patients
#14
Ana Ortega, Estefanía Tarazón, Carolina Gil-Cayuela, Luis Martínez-Dolz, Francisca Lago, José Ramón González-Juanatey, Juan Sandoval, Manuel Portolés, Esther Roselló-Lletí, Miguel Rivera
AIMS: Ischaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction, causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of the ASB gene family in ICM patients and relate these alterations to their haemodynamic and functional status. METHODS AND RESULTS: Epigenomic analysis was carried out using 16 left ventricular (LV) tissue samples, eight from ICM patients undergoing heart transplantation and eight from control (CNT) subjects without cardiac disease...
April 17, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29667338/variation-in-the-tek-gene-is-not-associated-with-asthma-but-with-allergic-conjunctivitis
#15
L E Fodor, A Gézsi, Z Gál, A Nagy, A Kiss, A Bikov, C Szalai
The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Recently, variations in the TEK gene have been found associated with asthma. The objective of the present study was to investigate whether variations in the TEK gene influenced the susceptibility to pediatric asthma and/or associated phenotypes like GINA status, viral- or exercise-induced asthma, allergic asthma, indoor, outdoor, inhalative allergies, IgE and eosonophil levels, allergic rhinitis and allergic conjunctivitis...
April 18, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#16
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667238/diet-quality-and-10-year-healthcare-costs-by-bmi-categories-in-the-mid-age-cohort-of-the-australian-longitudinal-study-on-women-s-health
#17
A Patterson, A Hure, T Burrows, J Jackson, C Collins
BACKGROUND: Better diets, as evaluated by diet quality indices, are associated with lower rates of morbidity and mortality. Although governments and researchers alike recognise the burden that obesity incurs for increased healthcare spending, there is insufficient evidence for the role of diet quality on healthcare costs. METHODS: Diet quality was assessed by the Australian Recommended Food Score (ARFS) for 6328 women aged 50-55 years from the Australian Longitudinal Study on Women's Health...
April 17, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29667237/the-trends-and-prevalence-of-obesity-and-morbid-obesity-among-australian-school-aged-children-1985-2014
#18
Joshua Xu, Louise L Hardy, Cici Z Guo, Sarah P Garnett
AIM: Children with obesity have a greater risk of adverse social and physical health outcomes. We examined temporal changes in body mass index (BMI) z-scores and the prevalence obesity and morbid obesity in children from 1985 to 2014. METHODS: Secondary data analysis of BMI data for children aged 7-15 years from five cross-sectional Australian datasets. Changes in age- and gender-adjusted BMI (BMI z-scores) and nutritional status were categorised using the International Obesity Task Force cut-off points...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667178/cost-utility-analysis-of-bariatric-surgery
#19
O Borisenko, V Lukyanov, A R Ahmed
BACKGROUND: The objective of the study was to evaluate the cost-utility of bariatric surgery in England. METHODS: A state-transition Markov model was developed to compare the costs and outcomes of two treatment approaches for patients with morbid obesity: bariatric surgery, including gastric bypass, sleeve gastrectomy and adjustable gastric banding; and non-surgical usual care. Parameters of the effectiveness of surgery and complications were informed by data from the UK National Bariatric Surgery Registry, the Scandinavian Obesity Registry and the Swedish Obese Subjects study...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29667175/first-line-drugs-for-hypertension
#20
REVIEW
James M Wright, Vijaya M Musini, Rupam Gill
BACKGROUND: This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that question. OBJECTIVES: To quantify the mortality and morbidity effects from different first-line antihypertensive drug classes: thiazides (low-dose and high-dose), beta-blockers, calcium channel blockers, ACE inhibitors, angiotensin II receptor blockers (ARB), and alpha-blockers, compared to placebo or no treatment...
April 18, 2018: Cochrane Database of Systematic Reviews
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