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https://www.readbyqxmd.com/read/29051839/external-quality-assessment-for-arbovirus-diagnostics-in-the-world-health-organization-western-pacific-region-2013-2016-improving-laboratory-quality-over-the-years
#1
Mohammad Yazid Abdad, Raynal C Squires, Sebastien Cognat, Christopher John Oxenford, Frank Konings
Arboviruses continue to pose serious public health threats in the World Health Organization (WHO) Western Pacific Region. As such, laboratories need to be equipped for their accurate detection. In 2011, to ensure test proficiency, the WHO Regional Office for the Western Pacific piloted an external quality assessment (EQA) programme for arbovirus diagnostics. By 2016, it had grown into a global programme with participation of 96 laboratories worldwide, including 25 laboratories from 19 countries, territories and areas in the Region...
July 2017: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/29040304/characterization-of-the-zika-virus-induced-small-rna-response-in-aedes-aegypti-cells
#2
Margus Varjak, Claire L Donald, Timothy J Mottram, Vattipally B Sreenu, Andres Merits, Kevin Maringer, Esther Schnettler, Alain Kohl
RNA interference (RNAi) controls arbovirus infections in mosquitoes. Two different RNAi pathways are involved in antiviral responses: the PIWI-interacting RNA (piRNA) and exogenous short interfering RNA (exo-siRNA) pathways, which are characterized by the production of virus-derived small RNAs of 25-29 and 21 nucleotides, respectively. The exo-siRNA pathway is considered to be the key mosquito antiviral response mechanism. In Aedes aegypti-derived cells, Zika virus (ZIKV)-specific siRNAs were produced and loaded into the exo-siRNA pathway effector protein Argonaute 2 (Ago2); although the knockdown of Ago2 did not enhance virus replication...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29038510/lure-and-kill-yeast-interfering-rna-larvicides-targeting-neural-genes-in-the-human-disease-vector-mosquito-aedes-aegypti
#3
Limb K Hapairai, Keshava Mysore, Yingying Chen, Elizabeth I Harper, Max P Scheel, Alexandra M Lesnik, Longhua Sun, David W Severson, Na Wei, Molly Duman-Scheel
New mosquito control strategies are vitally needed to address established arthropod-borne infectious diseases such as dengue and yellow fever and emerging diseases such as Zika and chikungunya, all of which are transmitted by the disease vector mosquito Aedes aegypti. In this investigation, Saccharomyces cerevisiae (baker's yeast) was engineered to produce short hairpin RNAs (shRNAs) corresponding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and leukocyte receptor cluster (lrc) member, two genes identified in a recent screen for A...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037978/expected-immunizations-and-health-protection-for-hajj-and-umrah-2018-an-overview
#4
REVIEW
Jaffar A Al-Tawfiq, Philippe Gautret, Ziad A Memish
BACKGROUND: The annual Hajj and Umrah are one of the largest recurring religious mass gatherings across the globe drawing pilgrims from more than 185 countries. The living circumstances and activities of the pilgrims may create an environment for the occurrence and spread of communicable diseases. Each year, the Health authority of the Kingdom of Saudi Arabia, in coordination with international health authorities, updates health requirements for pilgrims. The Hajj for 2017 took place from August 24 to September 5, 2017...
October 14, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#5
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29035317/systematic-review-land-cover-meteorological-and-socioeconomic-determinants-of-aedes-mosquito-habitat-for-risk-mapping
#6
REVIEW
Mohamed F Sallam, Chelsea Fizer, Andrew N Pilant, Pai-Yei Whung
Asian tiger and yellow fever mosquitoes (Aedes albopictus and Ae. aegypti) are global nuisances and are competent vectors for viruses such as Chikungunya (CHIKV), Dengue (DV), and Zika (ZIKV). This review aims to analyze available spatiotemporal distribution models of Aedes mosquitoes and their influential factors. A combination of five sets of 3-5 keywords were used to retrieve all relevant published models. Five electronic search databases were used: PubMed, MEDLINE, EMBASE, Scopus, and Google Scholar through 17 May 2017...
October 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29031082/quantum-associative-memory-with-linear-and-non-linear-algorithms-for-the-diagnosis-of-some-tropical-diseases
#7
J-P Tchapet Njafa, S G Nana Engo
This paper presents the QAMDiagnos, a model of Quantum Associative Memory (QAM) that can be a helpful tool for medical staff without experience or laboratory facilities, for the diagnosis of four tropical diseases (malaria, typhoid fever, yellow fever and dengue) which have several similar signs and symptoms. The memory can distinguish a single infection from a polyinfection. Our model is a combination of the improved versions of the original linear quantum retrieving algorithm proposed by Ventura and the non-linear quantum search algorithm of Abrams and Lloyd...
September 21, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29028528/inhibitors-of-yellow-fever-virus-replication-based-on-1-3-5-triphenyl-4-5-dihydropyrazole-scaffold-design-synthesis-and-antiviral-evaluation
#8
Rossella Fioravanti, Nicoletta Desideri, Antonio Carta, Elena Maria Atzori, Ilenia Delogu, Gabriella Collu, Roberta Loddo
By the antiviral screening of an in house library of pyrazoline compounds, 4-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide (5a) was identified as a promising hit compound for the development of anti- Yellow Fever Virus (YFV) agents. Structural optimization studies were focused on the development of 5a analogues which retain the potency as YFV inhibitors and show a reduced cytotoxicity. The synthesized 1-3,5-triphenyl-pyrazolines (4a-j, 5a-j, 6a-j) were evaluated in cell based assays for cytotoxicity and antiviral activity against representative viruses of two of the three genera of the Flaviviridae family, i...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29026637/a-review-of-selected-arboviruses-during-pregnancy
#9
REVIEW
Penélope Saldanha Marinho, Antonio José Cunha, Joffre Amim Junior, Arnaldo Prata-Barbosa
Arboviruses are emerging infectious diseases with the ability to expand geographically and rapidly affect large populations. The recent epidemic caused by the Zika virus in the Americas and congenital Zika syndrome associated with maternal infection has called out attention to the importance of studying arboviruses during pregnancy. This is a review on selected arboviruses infections during gestation, including Zika, Chikungunya, Dengue and Yellow Fever viruses. Issues such as historical overview, pathogenesis, transmission, clinical conditions, diagnosis, treatment and prevention are addressed...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29017606/temporal-distribution-and-insecticide-resistance-profile-of-two-major-arbovirus-vectors-aedes-aegypti-and-aedes-albopictus-in-yaound%C3%A3-the-capital-city-of-cameroon
#10
Basile Kamgang, Aurelie P Yougang, Micareme Tchoupo, Jacob M Riveron, Charles Wondji
BACKGROUND: Aedes aegypti and Ae. albopictus are the major epidemic vectors of several arbovirus diseases such as yellow fever, dengue, Zika and chikungunya worldwide. Both Aedes vectors are presents in Cameroon; however, knowledge on the dynamic of the distribution of these species across cities and their resistance profile to insecticide are limited. Here, we assessed the current distribution of Ae. aegypti and Ae. albopictus in Yaoundé, the Capital City, established the resistance profile to insecticides and explored the resistance mechanisms involved...
October 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29016323/enzootic-circulation-of-chikungunya-virus-in-east-africa-serological-evidence-in-nonhuman-kenyan-primates
#11
Gillian Eastwood, Rosemary C Sang, Matilde Guerbois, Evans L N Taracha, Scott C Weaver
Chikungunya virus (CHIKV) is a globally emerging pathogen causing debilitating arthralgia and fever in humans. First identified in Tanzania (1953), this mosquito-borne alphavirus received little further attention until a 2004 re-emergence in Kenya from an unknown source. This outbreak subsequently spread to the Indian Ocean, with adaptation for transmission by a new urban vector. Under the hypothesis that sylvatic progenitor cycles of CHIKV exist in Kenya (as reported in West Africa, between nonhuman primates (NHPs) and arboreal Aedes spp...
September 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991176/innate-immune-evasion-mediated-by-flaviviridae-non-structural-proteins
#12
REVIEW
Shun Chen, Zhen Wu, Mingshu Wang, Anchun Cheng
Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host's innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion...
October 7, 2017: Viruses
https://www.readbyqxmd.com/read/28986827/sampling-design-and-mosquito-trapping-for-surveillance-of-arboviral-activity
#13
Luís E Paternina, Juan David Rodas
Mosquitoes are the most important vectors for arboviral human diseases across the world. Diseases such as Dengue Fever (DF), West Nile Virus (WNV), Yellow Fever (YF), Japanese Encephalitis (JE), Venezuelan Equine Encephalitis (VEE), and St. Louis Encephalitis (SLE), among others, have a deep impact in public health. Usually mosquitoes acquire the arboviral infection when they feed on viremic animals (birds or mammals), so their infection can be detected along the year or in short periods of time (seasons). All of this depends on the frequency and seasonality of the encounters between viremic animals and vectors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986825/epidemiological-surveillance-of-viral-hemorrhagic-fevers-with-emphasis-on-clinical-virology
#14
Carolina Montoya-Ruiz, Juan David Rodas
This article will outline surveillance approaches for viral hemorrhagic fevers. Specific methods for surveillance of clinical samples will be emphasized. Separate articles will describe methods for surveillance of rodent-borne viruses (roboviruses) and arthropod-borne viruses (arboviruses). Since the appearance of hantaviruses and arenaviruses in the Americas, more than 30 different species in each group have been established, and therefore they have become the most frequently emerging viruses. Flaviviruses such as yellow fever and dengue viruses, although easier to recognize, are also more widely spread and therefore considered a very important public health issue, particularly for under-developed countries...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986822/global-spread-of-hemorrhagic-fever-viruses-predicting-pandemics
#15
Jean-Paul Gonzalez, Marc Souris, Willy Valdivia-Granda
As successive epidemics have swept the world, the scientific community has quickly learned from them about the emergence and transmission of communicable diseases. Epidemics usually occur when health systems are unprepared. During an unexpected epidemic, health authorities engage in damage control, fear drives action, and the desire to understand the threat is greatest. As humanity recovers, policy-makers seek scientific expertise to improve their "preparedness" to face future events.Global spread of disease is exemplified by the spread of yellow fever from Africa to the Americas, by the spread of dengue fever through transcontinental migration of mosquitos, by the relentless influenza virus pandemics, and, most recently, by the unexpected emergence of Ebola virus, spread by motorbike and long haul carriers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28983553/vaccination-challenges-in-confronting-the-resurgent-threat-from-yellow-fever
#16
Lin H Chen, Davidson H Hamer
No abstract text is available yet for this article.
October 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28982551/a-cell-based-high-throughput-screening-assay-for-the-discovery-of-cgas-sting-pathway-agonists
#17
Bowei Liu, Liudi Tang, Xiaohui Zhang, Julia Ma, Mohit Sehgal, Junjun Cheng, Xuexiang Zhang, Yan Zhou, Yanming Du, John Kulp, Ju-Tao Guo, Jinhong Chang
Stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that serves as a molecular hub for activation of interferon and inflammatory cytokine response by multiple cellular DNA sensors. Not surprisingly, STING has been demonstrated to play an important role in host defense against microorganisms and pharmacologic activation of STING is considered as an attractive strategy to treat viral diseases and boost antitumor immunity. In light of this we established a HepAD38-derived reporter cell line that expresses firefly luciferase in response to the activation of cyclic GMP-AMP synthase (cGAS)-STING pathway for high throughput screening (HTS) of small molecular human STING agonists...
October 2, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28978802/early-molecular-correlates-of-adverse-events-following-yellow-fever-vaccination
#18
Candice Yy Chan, Kuan Rong Chan, Camillus Jh Chua, Sharifah Nur Hazirah, Sujoy Ghosh, Eng Eong Ooi, Jenny G Low
The innate immune response shapes the development of adaptive immunity following infections and vaccination. However, it can also induce symptoms such as fever and myalgia, leading to the possibility that the molecular basis of immunogenicity and reactogenicity of vaccination are inseparably linked. To test this possibility, we used the yellow fever live-attenuated vaccine (YFLAV) as a model to study the molecular correlates of reactogenicity or adverse events (AEs). We analyzed the outcome of 68 adults who completed a YFLAV clinical trial, of which 43 (63...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28977185/risk-of-re-emergence-of-urban-yellow-fever-in-brazil
#19
Karina Ribeiro Leite Jardim Cavalcante, Pedro Luiz Tauil
No abstract text is available yet for this article.
July 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28975614/t-cell-receptor-alpha-variable-12-2-bias-in-the-immunodominant-response-to-yellow-fever-virus
#20
Amandine Bovay, Vincent Zoete, Garry Dolton, Anna M Bulek, David K Cole, Pierre J Rizkallah, Anna Fuller, Konrad Beck, Olivier Michielin, Daniel E Speiser, Andrew K Sewell, Silvia A Fuertes Marraco
The repertoire of human αβ T cell receptors (TCRs) is generated via somatic recombination of germline gene segments. Despite this enormous variation, certain epitopes can be immunodominant, associated with high frequencies of antigen-specific T cells and/or exhibit bias towards a TCR gene segment. Here, we studied the TCR repertoire of the HLA-A*0201-restricted epitope LLWNGPMAV (hereafter, A2/LLW) from Yellow Fever virus, which generates an immunodominant CD8(+) T cell response to the highly effective YF-17D vaccine...
October 3, 2017: European Journal of Immunology
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