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https://www.readbyqxmd.com/read/29451615/entomological-and-epidemiological-aspects-of-dengue-epidemics-in-fortaleza-cear%C3%A3-brazil-2001-2012
#1
Rhaquel de Morais Alves Barbosa Oliveira, Fernanda Montenegro de Carvalho Araújo, Luciano Pamplona de Góes Cavalcanti
OBJECTIVE: to characterize the entomological and epidemiological aspects of dengue epidemics occurred in Fortaleza, Ceará, Brazil, from 2001 to 2012. METHODS: descriptive study with data from the Information System for Notifiable Diseases (Sinan), Information System of Hospitalizations due to Yellow Fever and Dengue (2001-2009), National Program for Dengue Control (2010-2012), and Rapid Survey of Aedes aegypti Infestation Index, referring to the years in which the incidence of dengue was above 75%...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29447265/dynamic-remodeling-of-lipids-coincides-with-dengue-virus-replication-in-the-midgut-of-aedes-aegypti-mosquitoes
#2
Nunya Chotiwan, Barbara G Andre, Irma Sanchez-Vargas, M Nurul Islam, Jeffrey M Grabowski, Amber Hopf-Jannasch, Erik Gough, Ernesto Nakayasu, Carol D Blair, John T Belisle, Catherine A Hill, Richard J Kuhn, Rushika Perera
We describe the first comprehensive analysis of the midgut metabolome of Aedes aegypti, the primary mosquito vector for arboviruses such as dengue, Zika, chikungunya and yellow fever viruses. Transmission of these viruses depends on their ability to infect, replicate and disseminate from several tissues in the mosquito vector. The metabolic environments within these tissues play crucial roles in these processes. Since these viruses are enveloped, viral replication, assembly and release occur on cellular membranes primed through the manipulation of host metabolism...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29444675/current-and-future-distribution-of-aedes-aegypti-and-aedes-albopictus-diptera-culicidae-in-who-eastern-mediterranean-region
#3
Els Ducheyne, Nhu Nguyen Tran Minh, Nabil Haddad, Ward Bryssinckx, Evans Buliva, Frédéric Simard, Mamunur Rahman Malik, Johannes Charlier, Valérie De Waele, Osama Mahmoud, Muhammad Mukhtar, Ali Bouattour, Abdulhafid Hussain, Guy Hendrickx, David Roiz
BACKGROUND: Aedes-borne diseases as dengue, zika, chikungunya and yellow fever are an emerging problem worldwide, being transmitted by Aedes aegypti and Aedes albopictus. Lack of up to date information about the distribution of Aedes species hampers surveillance and control. Global databases have been compiled but these did not capture data in the WHO Eastern Mediterranean Region (EMR), and any models built using these datasets fail to identify highly suitable areas where one or both species may occur...
February 14, 2018: International Journal of Health Geographics
https://www.readbyqxmd.com/read/29443626/immunogenicity-of-fractional-dose-vaccine-during-a-yellow-fever-outbreak-preliminary-report
#4
Steve Ahuka-Mundeke, Rebecca M Casey, Jennifer B Harris, Meredith G Dixon, Pierre M Nsele, Gabriel M Kizito, Grace Umutesi, Janeen Laven, Gilson Paluku, Abdou S Gueye, Terri B Hyde, Guylain K M Sheria, Jean-Jacques Muyembe-Tanfum, J Erin Staples
Background In 2016, the response to a yellow fever outbreak in Angola and the Democratic Republic of Congo led to a global shortage of yellow fever vaccine. As a result, a fractional dose of the 17DD yellow fever vaccine (containing one fifth [0.1 ml] of the standard dose) was offered to 7.6 million children 2 years of age or older and nonpregnant adults in a preemptive campaign in Kinshasa. The goal of this study was to assess the immune response to the fractional dose in a large-scale campaign. Methods We recruited participants in four age strata at six vaccination sites...
February 14, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29435366/zika-chikungunya-and-dengue-the-causes-and-threats-of-new-and-re-emerging-arboviral-diseases
#5
REVIEW
Enny S Paixão, Maria Gloria Teixeira, Laura C Rodrigues
The recent emergence and re-emergence of viral infections transmitted by vectors-Zika, chikungunya, dengue, Japanese encephalitis, West Nile, yellow fever and others-is a cause for international concern. Using as examples Zika, chikungunya and dengue, we summarise current knowledge on characteristics of the viruses and their transmission, clinical features, laboratory diagnosis, burden, history, possible causes of the spread and the expectation for future epidemics. Arboviruses are transmitted by mosquitoes, are of difficult diagnosis, can have surprising clinical complications and cause severe burden...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29429035/inhibitory-effect-of-the-green-tea-molecule-egcg-against-dengue-virus-infection
#6
Muhareva Raekiansyah, Corazon C Buerano, Mark Anthony D Luz, Kouichi Morita
Dengue virus (DENV) infection is a major public health problem worldwide; however, specific antiviral drugs against it are not available. Hence, identifying effective antiviral agents for the prevention of DENV infection is important. In this study, we showed that the reportedly highly biologically active green-tea component epigallocatechin gallate (EGCG) inhibited dengue virus infection regardless of infecting serotype, but no or minimal inhibition was observed with other flaviviruses, including Japanese encephalitis virus, yellow fever virus, and Zika virus...
February 10, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29427798/evidence-for-multiple-sylvatic-transmission-cycles-during-the-2016-2017-yellow-fever-virus-outbreak-brazil
#7
Andres Moreira-Soto, Maria Celeste Torres, Marcos Cesar Lima de Mendonça, Maria Angelica Mares-Guia, Cintia Damasceno Dos Santos Rodrigues, Allison Fabri, Carolina Cardoso Dos Santos, Eliane Saraiva Machado Araújo, Carlo Fischer, Rita Maria Ribeiro Nogueira, Christian Drosten, Patricia Carvalho Sequeira, Jan Felix Drexler, Ana Maria Bispo de Filippis
OBJECTIVE: Since December 2016, Brazil has experienced an unusually large outbreak of yellow fever (YF). Whether urban transmission may contribute to the extent of the outbreak is unclear. The objective of this study was to characterize yellow fever virus (YFV) genomes and to identify spatial patterns to determine the distribution and origin of YF cases in Minas Gerais, Espírito Santo and Rio de Janeiro, the most affected Brazilian states during the current YFV outbreak. METHODS: We characterized near-complete YFV genomes from 14 human cases and two non-human primates (NHP), sampled from February to April 2017, retrieved epidemiological data of cases and used a geographic information system to investigate geospatial spread of YFV...
February 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29425967/combined-use-of-the-entomopathogenic-fungus-metarhizium-brunneum-and-the-mosquito-predator-toxorhynchites-brevipalpis-for-control-of-mosquito-larvae-is-this-a-risky-biocontrol-strategy
#8
Abeer M Alkhaibari, Thierry Maffeis, James C Bull, Tariq M Butt
Mosquitoes transmit several diseases, which are of global significance (malaria, dengue, yellow fever, Zika). The geographic range of mosquitoes is increasing due to climate change, tourism and trade. Both conidial and blastospore formulations of the entomopathogenic fungus, Metarhizium brunneum ARSEF 4556, are being investigated as mosquito larvicides. However, concerns have been raised over possible non-target impacts to arthropod mosquito predators such as larvae of Toxorhynchites brevipalpis which feed on larvae of mosquito vector species...
February 6, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29425195/a-natural-agonist-of-mosquito-trpa1-from-the-medicinal-plant-cinnamosma-fragrans-that-is-toxic-antifeedant-and-repellent-to-the-yellow-fever-mosquito-aedes-aegypti
#9
Edna Alfaro Inocente, Marguerite Shaya, Nuris Acosta, L Harinantenaina Rakotondraibe, Peter M Piermarini
Plants produce various secondary metabolites that offer a potential source of novel insecticides and repellents for the control of mosquito vectors. Plants of the genus Cinnamosma are endemic to, and widely-distributed throughout, the island of Madagascar. The barks of these species are commonly used in traditional medicines for treating a wide range of maladies. The therapeutic nature of the bark is thought to be associated with its enrichment of pungent drimane sesquiterpenes, which elicit antifeedant and toxic effects in some insects...
February 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29424106/seroprevalence-of-selected-flaviviruses-in-free-living-and-captive-capuchin-monkeys-in-the-state-of-pernambuco-brazil
#10
E F de Oliveira-Filho, R A S Oliveira, D R A Ferreira, P O Laroque, L J Pena, M M Valença-Montenegro, R A Mota, L H V G Gil
Mosquito-borne diseases such as dengue, yellow fever and, more recently, Chikungunya virus (CHIKV) and Zika virus (ZIKV) have a great impact in the public health. In addition, the presence of such viruses might have an impact on wild animal conservation as well as their possible role as animal reservoir. Here, we performed a serological survey searching for antibodies against a panel of flaviviruses [ZIKV, Dengue virus (DENV), Yellow Fever virus (YFV), West Nile virus (WNV), Saint Louis Encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV)] using plaque reduction neutralization test (PRNT90 ) in both free-ranging and captive capuchin monkeys (Sapajus flavius and Sapajus libidinosus)...
February 8, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29416874/optimization-of-commercially-available-zika-virus-antibodies-for-use-in-a-laboratory-developed-immunohistochemical-assay
#11
Brigid C Bollweg, Luciana Silva-Flannery, Pamela Spivey, Gillian L Hale
Zika virus (ZIKV) infection during pregnancy can cause adverse fetal outcomes and severe irreversible congenital birth defects including microcephaly. Immunohistochemistry (IHC) is a valuable diagnostic tool for detecting ZIKV antigens in tissues from cases of fetal loss in women infected with ZIKV, and for providing insights into disease pathogenesis. As a result, there is increasing demand for commercially available ZIKV antibodies for use in IHC assays. ZIKV antibodies were selected and obtained from commercial sources to include both mouse and rabbit hosts, and a variety of antigenic targets...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29412373/use-of-electronic-immunization-registry-in-the-surveillance-of-adverse-events-following-immunization
#12
Ana Paula Sayuri Sato, Vinícius Leati de Rossi Ferreira, Márcia de Cantuária Tauil, Laura Cunha Rodrigues, Mariana Bernardes Barros, Edmar Martineli, Ângela Aparecida Costa, Marta Inenami, Eliseu Alves Waldman
OBJECTIVE: To describe adverse events following vaccination (AEFV) of children under two years old and analyze trend of this events from 2000 to 2013, in the city of Araraquara (SP), Brazil. METHODS: This is a descriptive study conducted with data of the passive surveillance system of AEFV that is available in the electronic immunization registry (EIR) of the computerized medical record of the municipal health service (Juarez System). The study variables were: age, gender, vaccine, dose, clinical manifestations and hospitalization...
February 5, 2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29412361/entomopathogenic-fungi-and-their-potential-for-the-management-of-aedes-aegypti-diptera-culicidae-in-the-americas
#13
Harry C Evans, Simon L Elliot, Robert W Barreto
Classical biological control has been used extensively for the management of exotic weeds and agricultural pests, but never for alien insect vectors of medical importance. This simple but elegant control strategy involves the introduction of coevolved natural enemies from the centre of origin of the target alien species. Aedes aegypti - the primary vector of the dengue, yellow fever and Zika flaviviruses - is just such an invasive alien in the Americas where it arrived accidentally from its West African home during the slave trade...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29412261/not-a-polar-island-yellow-fever-spanish-medical-research-and-the-struggle-for-scientific-and-political-hegemony-in-late-nineteenth-century-cuba
#14
Francisco Javier Martínez
This paper explores questions related to yellow fever and the political destiny of Cuba in the late nineteenth century. A forgotten therapeutic device to treat the disease invented in that period, the "polar chamber" (cámara polar), provides a useful standpoint for reconstructing the tradition of Spanish yellow fever research in Cuba, a topic largely neglected by the medical historiography. The failed history of this device can also illuminate the complex struggle for scientific hegemony between Spanish, Cuban, and US institutions and researchers...
October 2017: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29410208/trends-in-insect-repellent-formulations-a-review
#15
REVIEW
Melanie Tavares, Márcio Robert Mattos da Silva, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Lolita Bodjolle-d'Almeira, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
The use of natural and synthetic repellents, marketed in different pharmaceutical forms, is growing in the world due to the emerging vector-borne viral diseases as Dengue, Zika, Chikungunya, Yellow Fever and Malaria. The choice of the ideal formulation will depend on a series of factors to be analyzed: type of repellent active (natural or synthetic), pharmaceutical forms (spray, lotion, cream, gel), action time duration (short or long), environment of exposure and the user (adult, pregnant women, children, newborn)...
February 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29409531/development-and-characterization-of-serotype-specific-monoclonal-antibodies-against-the-dengue-virus-4-denv-4-non-structural-protein-ns1
#16
Tesfaye Gelanew, Elizabeth Hunsperger
BACKGROUND: Dengue, caused by one of the four serologically distinct dengue viruses (DENV-1 to - 4), is a mosquito-borne disease of serious global health significance. Reliable and cost-effective diagnostic tests, along with effective vaccines and vector-control strategies, are highly required to reduce dengue morbidity and mortality. Evaluation studies revealed that many commercially available NS1 antigen (Ag) tests have limited sensitivity to DENV-4 serotype compared to the other three serotypes...
February 6, 2018: Virology Journal
https://www.readbyqxmd.com/read/29407015/yellow-fever-a-major-threat-to-public-health
#17
EDITORIAL
The Lancet
No abstract text is available yet for this article.
February 3, 2018: Lancet
https://www.readbyqxmd.com/read/29404420/limited-evidence-for-infection-of-urban-and-peri-urban-nonhuman-primates-with-zika-and-chikungunya-viruses-in-brazil
#18
Andres Moreira-Soto, Ianei de Oliveira Carneiro, Carlo Fischer, Marie Feldmann, Beate M Kümmerer, Nama Santos Silva, Uilton Góes Santos, Breno Frederico de Carvalho Dominguez Souza, Fernanda de Azevedo Liborio, Mônica Mafra Valença-Montenegro, Plautino de Oliveira Laroque, Fernanda Rosa da Fontoura, Alberto Vinicius Dantas Oliveira, Christian Drosten, Xavier de Lamballerie, Carlos Roberto Franke, Jan Felix Drexler
Chikungunya virus (CHIKV) and Zika virus (ZIKV) emerged in the Americas in 2013. Limited antigenic variability of CHIKV and ZIKV may restrict urban transmission cycles due to population protective immunity. In Africa, sylvatic transmission cycles involving nonhuman primates (NHP) are known for CHIKV and ZIKV, causing cyclic reemergence in humans. To evaluate whether sylvatic cycles can be expected in Latin America, we tested 207 NHP collected between 2012 and 2017 in urban and peri-urban settings in Brazil for infection with ZIKV and CHIKV...
January 2018: MSphere
https://www.readbyqxmd.com/read/29398634/existing-and-potential-infection-risk-zones-of-yellow-fever-worldwide-a-modelling-analysis
#19
Freya M Shearer, Joshua Longbottom, Annie J Browne, David M Pigott, Oliver J Brady, Moritz U G Kraemer, Fatima Marinho, Sergio Yactayo, Valdelaine E M de Araújo, Aglaêr A da Nóbrega, Nancy Fullman, Sarah E Ray, Jonathan F Mosser, Jeffrey D Stanaway, Stephen S Lim, Robert C Reiner, Catherine L Moyes, Simon I Hay, Nick Golding
BACKGROUND: Yellow fever cases are under-reported and the exact distribution of the disease is unknown. An effective vaccine is available but more information is needed about which populations within risk zones should be targeted to implement interventions. Substantial outbreaks of yellow fever in Angola, Democratic Republic of the Congo, and Brazil, coupled with the global expansion of the range of its main urban vector, Aedes aegypti, suggest that yellow fever has the propensity to spread further internationally...
February 1, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29398604/high-prevalence-of-rickettsia-helvetica-in-wild-small-mammal-populations-in-germany
#20
Stefan Fischer, Nastasja G Spierling, Elisa Heuser, Christopher Kling, Sabrina Schmidt, Ulrike M Rosenfeld, Daniela Reil, Christian Imholt, Jens Jacob, Rainer G Ulrich, Sandra Essbauer
Since the beginning of the 21st century, spotted fever rickettsioses are known as emerging diseases worldwide. Rickettsiae are obligately intracellular bacteria transmitted by arthropod vectors. The ecology of Rickettsia species has not been investigated in detail, but small mammals are considered to play a role as reservoirs. Aim of this study was to monitor rickettsiae in wild small mammals over a period of five years in four federal states of Germany. Initial screening of ear pinna tissues of 3939 animals by Pan-Rick real-time PCR targeting the citrate synthase (gltA) gene revealed 296 rodents of seven species and 19 shrews of two species positive for rickettsial DNA...
February 2, 2018: Ticks and Tick-borne Diseases
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