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Jihyoun Jeon, Mengmeng Du, Robert E Schoen, Michael Hoffmeister, Polly A Newcomb, Sonja I Berndt, Bette Caan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Graham G Giles, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Eric J Jacobs, Li Li, Yi Lin, Loïc Le Marchand, John D Potter, Flora Qu, Stephanie A Bien, Niha Zubair, Robert J Macinnis, Daniel D Buchanan, John L Hopper, Yin Cao, Reiko Nishihara, Gad Rennert, Martha L Slattery, Duncan C Thomas, Michael O Woods, Ross L Prentice, Stephen B Gruber, Yingye Zheng, Hermann Brenner, Richard B Hayes, Emily White, Ulrike Peters, Li Hsu
BACKGROUND & AIMS: Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lifestyle, environmental, or genetic risk factors. We developed models to determine risk of CRC, based on lifestyle and environmental factors and genetic variants, and to identify an optimal age to begin screening. METHODS: We collected data from 9748 CRC cases and 10,590 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colorectal Transdisciplinary study, from 1992 through 2005...
February 17, 2018: Gastroenterology
Vasiliki I Dimitrakopoulou, Konstantinos K Tsilidis, Philip C Haycock, Niki L Dimou, Kawthar Al-Dabhani, Richard M Martin, Sarah J Lewis, Marc J Gunter, Alison Mondul, Irene M Shui, Evropi Theodoratou, Katharina Nimptsch, Sara Lindström, Demetrius Albanes, Tilman Kühn, Timothy J Key, Ruth C Travis, Karani Santhanakrishnan Vimaleswaran, Peter Kraft, Brandon L Pierce, Joellen M Schildkraut
Objective  To determine if circulating concentrations of vitamin D are causally associated with risk of cancer. Design  Mendelian randomisation study. Setting  Large genetic epidemiology networks (the Genetic Associations and Mechanisms in Oncology (GAME-ON), the Genetic and Epidemiology of Colorectal Cancer Consortium (GECCO), and the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortiums, and the MR-Base platform). Participants  70 563 cases of cancer (22 898 prostate cancer, 15 748 breast cancer, 12 537 lung cancer, 11 488 colorectal cancer, 4369 ovarian cancer, 1896 pancreatic cancer, and 1627 neuroblastoma) and 84 418 controls...
October 31, 2017: BMJ: British Medical Journal
Yen-Chen Anne Feng, Kelly Cho, Sara Lindstrom, Peter Kraft, Jean Cormack, Liming Liang, Jane A Driver
Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 9931 to 54,162; SNPs were imputed to the 1000 Genomes European panel. Our results based on cross-trait LD Score regression showed a significant positive genetic correlation between AD and five cancers combined (colon, breast, prostate, ovarian, lung; r g  = 0...
October 2017: Human Genetics
Katerina Kopeckova, Tomas Buchler, Zbynek Bortlicek, Karel Hejduk, Renata Chloupkova, Bohuslav Melichar, Petra Pokorna, Jiri Tomasek, Zdenek Linke, Lubos Petruzelka, Igor Kiss, Jana Prausova
OBJECTIVE: To describe the use of regorafenib for the treatment of metastatic colorectal cancer (mCRC) in clinical practice in the Czech Republic, and to describe the clinical outcomes of patients in terms of safety and survival. PATIENTS AND METHODS: The data of patients treated with regorafenib were extracted from the national CORECT registry. The CORECT registry is a non-interventional post-marketing database, gathering information about patients with CRC and treated with targeted agents...
February 2017: Targeted Oncology
Igor Kiss, Jitka Mlcochova, Zbynek Bortlicek, Alexandr Poprach, Jiri Drabek, Petra Vychytilova-Faltejskova, Marek Svoboda, Tomas Buchler, Stanislav Batko, Ales Ryska, Marian Hajduch, Ondrej Slaby
BACKGROUND: In metastatic colorectal cancer (mCRC), panitumumab is generally considered to be ineffective after the progression on cetuximab therapy. However, few studies have demonstrated that a small subset of mCRC patients may benefit from panitumumab in this setting. PATIENTS AND METHODS: In our study, wild-type KRAS mCRC patients, enrolled into the nationwide Czech registry CORECT between January 2007 and December 2012, were screened for panitumumab therapy after progression on cetuximab...
2016: Anticancer Research
Nikhil K Khankari, Xiao-Ou Shu, Wanqing Wen, Peter Kraft, Sara Lindström, Ulrike Peters, Joellen Schildkraut, Fredrick Schumacher, Paolo Bofetta, Angela Risch, Heike Bickeböller, Christopher I Amos, Douglas Easton, Rosalind A Eeles, Stephen B Gruber, Christopher A Haiman, David J Hunter, Stephen J Chanock, Brandon L Pierce, Wei Zheng
BACKGROUND: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. METHODS AND FINDINGS: A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases...
September 2016: PLoS Medicine
Sara Karami, Younghun Han, Mala Pande, Iona Cheng, James Rudd, Brandon L Pierce, Ellen L Nutter, Fredrick R Schumacher, Zsofia Kote-Jarai, Sara Lindstrom, John S Witte, Shenying Fang, Jiali Han, Peter Kraft, David J Hunter, Fengju Song, Rayjean J Hung, James McKay, Stephen B Gruber, Stephen J Chanock, Angela Risch, Hongbing Shen, Christopher A Haiman, Lisa Boardman, Cornelia M Ulrich, Graham Casey, Ulrike Peters, Ali Amin Al Olama, Andrew Berchuck, Sonja I Berndt, Stephane Bezieau, Paul Brennan, Hermann Brenner, Louise Brinton, Neil Caporaso, Andrew T Chan, Jenny Chang-Claude, David C Christiani, Julie M Cunningham, Douglas Easton, Rosalind A Eeles, Timothy Eisen, Manish Gala, Steven J Gallinger, Simon A Gayther, Ellen L Goode, Henrik Grönberg, Brian E Henderson, Richard Houlston, Amit D Joshi, Sébastien Küry, Mari T Landi, Loic Le Marchand, Kenneth Muir, Polly A Newcomb, Jenny Permuth-Wey, Paul Pharoah, Catherine Phelan, John D Potter, Susan J Ramus, Harvey Risch, Joellen Schildkraut, Martha L Slattery, Honglin Song, Nicolas Wentzensen, Emily White, Fredrik Wiklund, Brent W Zanke, Thomas A Sellers, Wei Zheng, Nilanjan Chatterjee, Christopher I Amos, Jennifer A Doherty
Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoining CLPTM1L region are associated with risk of multiple cancers. We therefore investigated associations between variants in 22 telomere structure and maintenance gene regions and colorectal, breast, prostate, ovarian, and lung cancer risk. We performed subset-based meta-analyses of 204,993 directly-measured and imputed SNPs among 61,851 cancer cases and 74,457 controls of European descent...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
Chi Gao, Chirag J Patel, Kyriaki Michailidou, Ulrike Peters, Jian Gong, Joellen Schildkraut, Fredrick R Schumacher, Wei Zheng, Paolo Boffetta, Isabelle Stucker, Walter Willett, Stephen Gruber, Douglas F Easton, David J Hunter, Thomas A Sellers, Christopher Haiman, Brian E Henderson, Rayjean J Hung, Christopher Amos, Brandon L Pierce, Sara Lindström, Peter Kraft
BACKGROUND: Adiposity traits have been associated with risk of many cancers in observational studies, but whether these associations are causal is unclear. Mendelian randomization (MR) uses genetic predictors of risk factors as instrumental variables to eliminate reverse causation and reduce confounding bias. We performed MR analyses to assess the possible causal relationship of birthweight, childhood and adult body mass index (BMI), and waist-hip ratio (WHR) on the risks of breast, ovarian, prostate, colorectal and lung cancers...
June 2016: International Journal of Epidemiology
Belén Agudo, Gema Díaz, Yago González-Lama
No abstract text is available yet for this article.
December 2016: Journal of Crohn's & Colitis
Chenjie Zeng, Koichi Matsuda, Wei-Hua Jia, Jiang Chang, Sun-Seog Kweon, Yong-Bing Xiang, Aesun Shin, Sun Ha Jee, Dong-Hyun Kim, Ben Zhang, Qiuyin Cai, Xingyi Guo, Jirong Long, Nan Wang, Regina Courtney, Zhi-Zhong Pan, Chen Wu, Atsushi Takahashi, Min-Ho Shin, Keitaro Matsuo, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Soriul Kim, Keum Ji Jung, Yoon-Ok Ahn, Zefang Ren, Hong-Lan Li, Jie Wu, Jiajun Shi, Wanqing Wen, Gong Yang, Bingshan Li, Bu-Tian Ji, Hermann Brenner, Robert E Schoen, Sébastien Küry, Stephen B Gruber, Fredrick R Schumacher, Stephanie L Stenzel, Graham Casey, John L Hopper, Mark A Jenkins, Hyeong-Rok Kim, Jin-Young Jeong, Ji Won Park, Kazuo Tajima, Sang-Hee Cho, Michiaki Kubo, Xiao-Ou Shu, Dongxin Lin, Yi-Xin Zeng, Wei Zheng
BACKGROUND & AIMS: Known genetic factors explain only a small fraction of genetic variation in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk loci for CRC. METHODS: This discovery stage included 8027 cases and 22,577 controls of East-Asian ancestry. Promising variants were evaluated in studies including as many as 11,044 cases and 12,047 controls. Tumor-adjacent normal tissues from 188 patients were analyzed to evaluate correlations of risk variants with expression levels of nearby genes...
June 2016: Gastroenterology
Ondrej Fiala, Tomas Buchler, Beatrice Mohelnikova-Duchonova, Bohuslav Melichar, Vit Martin Matejka, Lubos Holubec, Jana Kulhankova, Zbynek Bortlicek, Marie Bartouskova, Vaclav Liska, Ondrej Topolcan, Monika Sedivcova, Jindrich Finek
The v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are found in 35-45 % of colorectal cancer (CRC) cases. Although the association between the RAS signaling and angiogenesis is well known, the negative predictive value of KRAS mutation has not been established in patients treated with bevacizumab. The aim of this study was to evaluate the association between specific KRAS mutation types and outcome of patients with metastatic CRC treated with bevacizumab. The study included 404 patients with metastatic CRC (mCRC) treated with bevacizumab...
May 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Meng-Nan Ma, Ying Zhuo, Ruo Yuan, Ya-Qin Chai
A highly sensitive electrochemiluminescent (ECL) aptasensor was constructed using semicarbazide (Sem) as co-reaction accelerator to promote the ECL reaction rate of CdTe quantum dots (CdTe QDs) and the co-reactant of peroxydisulfate (S2O8(2-)) for boosting signal amplification. The co-reaction accelerator is a species that when it is introduced into the ECL system containing luminophore and co-reactant, it can interact with co-reactant rather than luminophore to promote the ECL reaction rate of luminophore and co-reactant; thus the ECL signal is significantly amplified in comparison with that in which only luminophore and co-reactant are present...
November 17, 2015: Analytical Chemistry
Rayjean J Hung, Cornelia M Ulrich, Ellen L Goode, Yonathan Brhane, Kenneth Muir, Andrew T Chan, Loic Le Marchand, Joellen Schildkraut, John S Witte, Rosalind Eeles, Paolo Boffetta, Margaret R Spitz, Julia G Poirier, David N Rider, Brooke L Fridley, Zhihua Chen, Christopher Haiman, Fredrick Schumacher, Douglas F Easton, Maria Teresa Landi, Paul Brennan, Richard Houlston, David C Christiani, John K Field, Heike Bickeböller, Angela Risch, Zsofia Kote-Jarai, Fredrik Wiklund, Henrik Grönberg, Stephen Chanock, Sonja I Berndt, Peter Kraft, Sara Lindström, Ali Amin Al Olama, Honglin Song, Catherine Phelan, Nicholas Wentzensen, Ulrike Peters, Martha L Slattery, Thomas A Sellers, Graham Casey, Stephen B Gruber, David J Hunter, Christopher I Amos, Brian Henderson
BACKGROUND: Inflammation has been hypothesized to increase the risk of cancer development as an initiator or promoter, yet no large-scale study of inherited variation across cancer sites has been conducted. METHODS: We conducted a cross-cancer genomic analysis for the inflammation pathway based on 48 genome-wide association studies within the National Cancer Institute GAME-ON Network across five common cancer sites, with a total of 64 591 cancer patients and 74 467 control patients...
November 2015: Journal of the National Cancer Institute
Chenan Zhang, Jennifer A Doherty, Stephen Burgess, Rayjean J Hung, Sara Lindström, Peter Kraft, Jian Gong, Christopher I Amos, Thomas A Sellers, Alvaro N A Monteiro, Georgia Chenevix-Trench, Heike Bickeböller, Angela Risch, Paul Brennan, James D Mckay, Richard S Houlston, Maria Teresa Landi, Maria N Timofeeva, Yufei Wang, Joachim Heinrich, Zsofia Kote-Jarai, Rosalind A Eeles, Ken Muir, Fredrik Wiklund, Henrik Grönberg, Sonja I Berndt, Stephen J Chanock, Fredrick Schumacher, Christopher A Haiman, Brian E Henderson, Ali Amin Al Olama, Irene L Andrulis, John L Hopper, Jenny Chang-Claude, Esther M John, Kathleen E Malone, Marilie D Gammon, Giske Ursin, Alice S Whittemore, David J Hunter, Stephen B Gruber, Julia A Knight, Lifang Hou, Loic Le Marchand, Polly A Newcomb, Thomas J Hudson, Andrew T Chan, Li Li, Michael O Woods, Habibul Ahsan, Brandon L Pierce
Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers. These inconsistencies are likely attributable, in part, to biases that arise due to post-diagnostic and post-treatment TL measurement. To avoid such biases, we used a Mendelian randomization approach and estimated associations between nine TL-associated SNPs and risk for five common cancer types (breast, lung, colorectal, ovarian and prostate cancer, including subtypes) using data on 51 725 cases and 62 035 controls...
September 15, 2015: Human Molecular Genetics
Ilona Kocakova, Bohuslav Melichar, Ivo Kocak, Zbynek Bortlicek, Tomas Büchler, Ladislav Dusek, Luboš Petruzelka, Milan Kohoutek, Jana Prausová, Jindrich Finek, Beatrice Mohelnikova-Duchonova, Rostislav Vyzula
AIM: To retrospectively compare the efficacy of two irinotecan-based chemotherapy regimens combined with bevacizumab in first-line therapy of metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: The data of 558 patients with mCRC treated with first-line bevacizumab plus irinotecan-containing regimen were obtained from the national CORECT registry that collects data of all patients with mCRC treated with targeted-agents. The treatment outcomes of patients treated with bevacizumab plus irinotecan, 5-fluorouracil and folinic acid (FOLFIRI) were compared to patients treated with bevacizumab plus irinotecan and capecitabine (XELIRI)...
June 2015: Anticancer Research
Li Hsu, Jihyoun Jeon, Hermann Brenner, Stephen B Gruber, Robert E Schoen, Sonja I Berndt, Andrew T Chan, Jenny Chang-Claude, Mengmeng Du, Jian Gong, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, Carolyn M Hutter, Yi Lin, Reiko Nishihara, Shuji Ogino, Ross L Prentice, Fredrick R Schumacher, Daniela Seminara, Martha L Slattery, Duncan C Thomas, Mark Thornquist, Polly A Newcomb, John D Potter, Yingye Zheng, Emily White, Ulrike Peters
BACKGROUND & AIMS: Risk for colorectal cancer (CRC) can be greatly reduced through screening. To aid in the development of screening strategies, we refined models designed to determine risk of CRC by incorporating information from common genetic susceptibility loci. METHODS: By using data collected from more than 12,000 participants in 6 studies performed from 1990 through 2011 in the United States and Germany, we developed risk determination models based on sex, age, family history, genetic risk score (number of risk alleles carried at 27 validated common CRC susceptibility loci), and history of endoscopic examinations...
June 2015: Gastroenterology
Kateřina Kubáčková, Zbyněk Bortlíček, Tomáš Pikus, Zdeněk Linke, Petra Pokorná, Rostislav Vyzula, Jana Prausová
AIM: This retrospective analysis investigated the effectiveness of combination therapy with bevacizumab and chemotherapy in the first-line treatment of patients with KRAS wild-type metastatic colorectal cancer. PATIENTS & METHODS: Patients with KRAS wild-type metastatic colorectal cancer in the CORECT registry who initiated treatment with bevacizumab between 2008 and 2012 were enrolled. Overall survival and progression-free survival were the main effectiveness end points...
2015: Future Oncology
Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher A Haiman, Motoki Iwasaki, Lynne R Wilkens, Lenora W M Loo, David Van Den Berg, Laurence N Kolonel, Brian E Henderson, Temitope O Keku, Robert S Sandler, Lisa B Signorello, William J Blot, Polly A Newcomb, Mala Pande, Christopher I Amos, Dee W West, Stéphane Bézieau, Sonja I Berndt, Brent W Zanke, Li Hsu, Noralane M Lindor, Robert W Haile, John L Hopper, Mark A Jenkins, Steven Gallinger, Graham Casey, Stephanie L Stenzel, Fredrick R Schumacher, Ulrike Peters, Stephen B Gruber, Shoichiro Tsugane, Daniel O Stram, Loïc Le Marchand
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1...
August 8, 2014: Nature Communications
Ben Zhang, Wei-Hua Jia, Koichi Matsuda, Sun-Seog Kweon, Keitaro Matsuo, Yong-Bing Xiang, Aesun Shin, Sun Ha Jee, Dong-Hyun Kim, Qiuyin Cai, Jirong Long, Jiajun Shi, Wanqing Wen, Gong Yang, Yanfeng Zhang, Chun Li, Bingshan Li, Yan Guo, Zefang Ren, Bu-Tian Ji, Zhi-Zhong Pan, Atsushi Takahashi, Min-Ho Shin, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Soriul Kim, Yoon-Ok Ahn, Andrew T Chan, Jenny Chang-Claude, Martha L Slattery, Stephen B Gruber, Fredrick R Schumacher, Stephanie L Stenzel, Graham Casey, Hyeong-Rok Kim, Jin-Young Jeong, Ji Won Park, Hong-Lan Li, Satoyo Hosono, Sang-Hee Cho, Michiaki Kubo, Xiao-Ou Shu, Yi-Xin Zeng, Wei Zheng
Known genetic loci explain only a small proportion of the familial relative risk of colorectal cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with 14,963 cases and 31,945 controls and identified 6 new loci associated with CRC risk (P = 3.42 × 10(-8) to 9.22 × 10(-21)) at 10q22.3, 10q25.2, 11q12.2, 12p13.31, 17p13.3 and 19q13.2. Two of these loci map to genes (TCF7L2 and TGFB1) with established roles in colorectal tumorigenesis. Four other loci are located in or near genes involved in transcriptional regulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell motility and metastasis (CD9), and cell growth and differentiation (NXN)...
June 2014: Nature Genetics
Jian-Min Han, Guang Hong, Maimaitishawuti Dilinuer, Hong Lin, Gang Zheng, Xin-Zhi Wang, Keiichi Sasaki
OBJECTIVE: To examine the initial viscosity and adhesive strength of modern denture adhesives in vitro. MATERIALS AND METHODS: Three cream-type denture adhesives (Poligrip S, Corect Cream, Liodent Cream; PGS, CRC, LDC) and three powder-type denture adhesives (Poligrip Powder, New Faston, Zanfton; PGP, FSN, ZFN) were used in this study. The initial viscosity was measured using a controlled-stress rheometer. The adhesive strength was measured according to ISO-10873 recommended procedures...
November 2014: Acta Odontologica Scandinavica
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