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Lixian Wang, Jin Lin, Chungu Xia, Wei Sun
No abstract text is available yet for this article.
March 21, 2024: Journal of Organic Chemistry
#2
JOURNAL ARTICLE
R S Laskar, C Qu, J R Huyghe, T Harrison, R B Hayes, Y Cao, P T Campbell, R Steinfelder, F R Talukdar, H Brenner, S Ogino, S Brendt, D T Bishop, D D Buchanan, A T Chan, M Cotterchio, S B Gruber, A Gsur, B van Guelpen, M A Jenkins, T O Keku, B M Lynch, L Le Marchand, R M Martin, K McCarthy, V Moreno, R Pearlman, M Song, K K Tsilidis, P Vodička, M O Woods, K Wu, L Hsu, M J Gunter, U Peters, N Murphy
BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. Colorectal cancer (CRC) has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC...
February 24, 2024: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#3
JOURNAL ARTICLE
Marina O Rontogianni, Emmanouil Bouras, Elom Kouassivi Aglago, Heinz Freisling, Neil Murphy, Michelle Cotterchio, Jochen Hampe, Annika Lindblom, Rish K Pai, Paul D P Pharoah, Amanda I Phipps, Franzel J B van Duijnhoven, Kala Visvanathan, Bethany van Guelpen, Christopher I Li, Hermann Brenner, Andrew J Pellatt, Shuji Ogino, Marc J Gunter, Ulrike Peters, Sofia Christakoudi, Konstantinos K Tsilidis
BACKGROUND: Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing...
January 31, 2024: International Journal of Obesity
#4
JOURNAL ARTICLE
Heather Elder, Simona G Lang, Merceditas Villanueva, Betsey John, Kathleen Roosevelt, Frederick L Altice, Kathleen A Brady, Briana Gibson, Marianne Buchelli, Alfred DeMaria, Liisa M Randall
BACKGROUND: "Data to Care" (D2C) is a strategy which relies on a combination of public health surveillance data supplemented by clinic data to support continuity of HIV care. The Cooperative Re-Engagement Controlled Trial (CoRECT) was a CDC-sponsored randomized controlled trial of a D2C model, which provided an opportunity to examine the process of implementing an intervention for people with HIV (PWH) who are out-of-care across three public health department jurisdictions. Using the EPIS (Exploration, Preparation, Implementation, Sustainment) framework, we aimed to retrospectively describe the implementation process for each site to provide insights and guidance to inform future D2C activities implemented by public health agencies and their clinical and community partners...
2023: Frontiers in Public Health
#5
JOURNAL ARTICLE
Emmanouil Bouras, Andre E Kim, Yi Lin, John Morrison, Mengmeng Du, Demetrius Albanes, Elizabeth L Barry, James W Baurley, Sonja I Berndt, Stephanie A Bien, Timothy D Bishop, Hermann Brenner, Arif Budiarto, Andrea Burnett-Hartman, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Tjeng Wawan Cenggoro, Andrew T Chan, Jenny Chang-Claude, David V Conti, Michelle Cotterchio, Matthew Devall, Virginia Diez-Obrero, Niki Dimou, David A Drew, Jane C Figueiredo, Graham G Giles, Stephen B Gruber, Marc J Gunter, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Amit D Joshi, Eric S Kawaguchi, Temitope O Keku, Anshul Kundaje, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Brigid M Lynch, Bharuno Mahesworo, Satu Männistö, Victor Moreno, Neil Murphy, Polly A Newcomb, Mireia Obón-Santacana, Jennifer Ose, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Andrew J Pellatt, Anita R Peoples, Elizabeth A Platz, John D Potter, Lihong Qi, Conghui Qu, Gad Rennert, Edward Ruiz-Narvaez, Lori C Sakoda, Stephanie L Schmit, Anna Shcherbina, Mariana C Stern, Yu-Ru Su, Catherine M Tangen, Duncan C Thomas, Yu Tian, Caroline Y Um, Franzel Jb van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Jun Wang, Emily White, Alicja Wolk, Michael O Woods, Cornelia M Ulrich, Li Hsu, W James Gauderman, Ulrike Peters, Konstantinos K Tsilidis
BACKGROUND: Epidemiological and experimental evidence suggests that higher folate intake is associated with a decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate's role in CRC. OBJECTIVE: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk...
August 26, 2023: American Journal of Clinical Nutrition
#6
JOURNAL ARTICLE
Thu Thi Pham, Katharina Nimptsch, Nikos Papadimitriou, Krasimira Aleksandrova, Mazda Jenab, Marc J Gunter, Loic Le Marchand, Li Li, Brigid M Lynch, Sergi Castellví-Bel, Amanda I Phipps, Stephanie L Schmit, Hermann Brenner, Shuji Ogino, Edward Giovannucci, Tobias Pischon
PURPOSE: Resistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. However, evidence from observational studies has been inconsistent. Mendelian randomization may be a complementary method to examine this association. METHODS: We conducted a two-sample Mendelian randomization to estimate the association between genetically determined circulating resistin concentrations and risk of colorectal cancer (CRC)...
August 21, 2023: Journal of Cancer Research and Clinical Oncology
#7
JOURNAL ARTICLE
Niki Dimou, Andre E Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K Aglago, Emmanouil Bouras, Peter T Campbell, Graham Casey, Steven Gallinger, Stephen B Gruber, Mark A Jenkins, Yi Lin, Victor Moreno, Edward Ruiz-Narvaez, Mariana C Stern, Yu Tian, Kostas K Tsilidis, Volker Arndt, Elizabeth L Barry, James W Baurley, Sonja I Berndt, Stéphane Bézieau, Stephanie A Bien, D Timothy Bishop, Hermann Brenner, Arif Budiarto, Robert Carreras-Torres, Tjeng Wawan Cenggoro, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Xuechen Chen, David V Conti, Christopher H Dampier, Matthew Devall, David A Drew, Jane C Figueiredo, Graham G Giles, Andrea Gsur, Tabitha A Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R Huyghe, Kristina Jordahl, Eric Kawaguchi, Temitope O Keku, Susanna C Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John Morrison, Polly A Newcomb, Christina C Newton, Mireia Obon-Santacana, Jennifer Ose, Rish K Pai, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R Peoples, Paul D P Pharoah, Elizabeth A Platz, John D Potter, Gad Rennert, Peter C Scacheri, Robert E Schoen, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Cornelia M Ulrich, Caroline Y Um, Franzel J B van Duijnhoven, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Emily White, Alicja Wolk, Michael O Woods, Conghui Qu, Anshul Kundaje, Li Hsu, W James Gauderman, Marc J Gunter, Ulrike Peters
BACKGROUND: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. METHODS: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d...
June 26, 2023: British Journal of Cancer
#8
JOURNAL ARTICLE
Elom K Aglago, Andre E Kim, Yi Lin, Conghui Qu, Marina Evangelou, Yu Ren, John Morrison, Demetrius Albanes, Volker Arndt, Elizabeth L Barry, James W Baurley, Sonja I Berndt, Stephanie A Bien, D Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D Buchanan, Arif Budiarto, Robert Carreras-Torres, Graham Casey, Tjeng Wawan Cenggoro, Andrew T Chan, Jenny Chang-Claude, Xuechen Chen, David V Conti, Matthew Devall, Virginia Díez-Obrero, Niki Dimou, David Drew, Jane C Figueiredo, Steven Gallinger, Graham G Giles, Stephen B Gruber, Andrea Gsur, Marc J Gunter, Heather Hampel, Sophia Harlid, Akihisa Hidaka, Tabitha A Harrison, Michael Hoffmeister, Jeroen R Huyghe, Mark A Jenkins, Kristina Jordahl, Amit D Joshi, Eric S Kawaguchi, Temitope O Keku, Anshul Kundaje, Susanna C Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Brigid M Lynch, Bharuno Mahesworo, Marko Mandic, Mireia Obón-Santacana, Victor Moreno, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A Newcomb, Shuji Ogino, Jennifer Ose, Rish K Pai, Julie R Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R Peoples, Elizabeth A Platz, John D Potter, Ross L Prentice, Gad Rennert, Edward Ruiz-Narvaez, Lori C Sakoda, Peter C Scacheri, Stephanie L Schmit, Robert E Schoen, Anna Shcherbina, Martha L Slattery, Mariana C Stern, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Yu Tian, Cornelia M Ulrich, Fränzel J B van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Jun Wang, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Natalia Zemlianskaia, Li Hsu, W James Gauderman, Ulrike Peters, Konstantinos K Tsilidis, Peter T Campbell
Colorectal cancer (CRC) risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment (G×E) interactions can provide biological insights into the effects of obesity on CRC risk. Here, we assessed potential genome-wide G×E interactions between body mass index (BMI) and common single nucleotide polymorphisms (SNPs) for CRC risk using data from 36,415 CRC cases and 48,451 controls from three international CRC consortia (CCFR, CORECT, and GECCO). The G×E tests included the conventional logistic regression using multiplicative terms (one-degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G×E interactions under specific conditions...
May 30, 2023: Cancer Research
#9
JOURNAL ARTICLE
Philip C Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N Lemaitre, Stephen Burgess, Nikhil K Khankari, Konstantinos K Tsilidis, Tom R Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M Birmann, Tracy OMara, Amanda B Spurdle, Mark M Iles, Matthew H Law, Susan L Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C Williams, Robert C Block, Christopher I Amos, Rayjean J Hung, Wei Zheng, Marc J Gunter, George Davey Smith, Caroline Relton, Richard M Martin
BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European and East Asian ancestry individuals. We defined the primary exposure as PUFA desaturase activity, proxied by rs174546 at the FADS locus. Secondary exposures were defined as omega 3 and omega 6 PUFAs that could be proxied by genetic polymorphisms outside the FADS region...
May 2023: EBioMedicine
#10
JOURNAL ARTICLE
Sara Lindström, Lu Wang, Helian Feng, Arunabha Majumdar, Sijia Huo, James Macdonald, Tabitha Harrison, Constance Turman, Hongjie Chen, Nicholas Mancuso, Theo Bammler, Steve Gallinger, Stephen B Gruber, Marc J Gunter, Loic Le Marchand, Victor Moreno, Kenneth Offit, Immaculata De Vivo, Tracy A O'Mara, Amanda B Spurdle, Ian Tomlinson, Rebecca Fitzgerald, Puya Gharahkhani, Ines Gockel, Janusz Jankowski, Stuart Macgregor, Johannes Schumacher, Jill Barnholtz-Sloan, Melissa L Bondy, Richard S Houlston, Robert B Jenkins, Beatrice Melin, Margaret Wrensch, Paul Brennan, David C Christiani, Mattias Johansson, James Mckay, Melinda C Aldrich, Christopher I Amos, Maria Teresa Landi, Adonina Tardon, D Timothy Bishop, Florence Demenais, Alisa M Goldstein, Mark M Iles, Peter A Kanetsky, Matthew H Law, Laufey T Amundadottir, Rachael Stolzenberg-Solomon, Brian M Wolpin, Alison Klein, Gloria Petersen, Harvey Risch, Stephen J Chanock, Mark P Purdue, Ghislaine Scelo, Paul Pharoah, Siddhartha Kar, Rayjean J Hung, Bogdan Pasaniuc, Peter Kraft
BACKGROUND: The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci. METHODS: We collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry...
June 8, 2023: Journal of the National Cancer Institute
#11
JOURNAL ARTICLE
Jingyuan Wang, Joshua Millstein, Yan Yang, Sebastian Stintzing, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Christoph Mancao, Chiara Cremolini, Tianshu Liu, Volker Heinemann, Alfredo Falcone, Lin Shen, Heinz-Josef Lenz
BACKGROUND: Antiangiogenic drug (AAD)-triggered oxygen and nutrient depletion through suppression of angiogenesis switches glucose-dependent to lipid-dependent metabolism. Blocking fatty acid oxidation can enhance AAD-mediated anti-tumor effects in colorectal cancer (CRC). Therefore, we hypothesised that genetic variants in the lipid metabolism pathway may predict clinical outcomes [overall response rate (ORR), overall survival (OS) and progression-free survival (PFS)] in metastatic CRC (mCRC) patients receiving bevacizumab-based first-line treatment...
March 2023: EClinicalMedicine
#12
JOURNAL ARTICLE
Jesse O'Shea, Robyn Neblett Fanfair, Tiffany Williams, George Khalil, Kathleen A Brady, Alfred DeMaria, Merceditas Villanueva, Liisa M Randall, Heidi Jenkins, Frederick L Altice, Nasima Camp, Crystal Lucas, Marianne Buchelli, Taraz Samandari, Paul J Weidle
BACKGROUND: A collaborative, data-to-care strategy to identify persons with HIV (PWH) newly out-of-care, combined with an active public health intervention, significantly increases the proportion of PWH re-engaged in HIV care. We assessed this strategy's impact on durable viral suppression (DVS). METHODS: A multi-site, prospective randomized controlled trial for out-of-care individuals using a data-to-care strategy and comparing public health field services to locate, contact, and facilitate access to care versus the standard of care (SOC)...
February 21, 2023: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#13
JOURNAL ARTICLE
Sophie Pilleron, Camille Maringe, Eva J A Morris, Clémence Leyrat
BACKGROUND: In observational studies, the risk of immortal-time bias (ITB) increases with the likelihood of early death, itself increasing with age. We investigated how age impacts the magnitude of ITB when estimating the effect of surgery on 1-year overall survival (OS) in patients with Stage IV colon cancer aged 50-74 and 75-84 in England. METHODS: Using simulations, we compared estimates from a time-fixed exposure model to three statistical methods addressing ITB: time-varying exposure, delayed entry and landmark methods...
February 9, 2023: British Journal of Cancer
#14
JOURNAL ARTICLE
Ram K Shrestha, Robyn Neblett Fanfair, Liisa M Randall, Crystal Lucas, Lisa Nichols, Nasima Camp, Kathleen A Brady, Heidi Jenkins, Frederick L Altice, Alfred DeMaria, Merceditas Villanueva, Paul J Weidle
INTRODUCTION: Data-to-care programmes utilize surveillance data to identify persons who are out of HIV care, re-engage them in care and improve HIV care outcomes. We assess the costs and cost-effectiveness of re-engagement in an HIV care intervention in the United States. METHODS: The Cooperative Re-engagement Control Trial (CoRECT) employed a data-to-care collaborative model between health departments and HIV care providers, August 2016-July 2018. The health departments in Connecticut (CT), Massachusetts (MA) and Philadelphia (PHL) collaborated with HIV clinics to identify newly out-of-care patients and randomize them to receive usual linkage and engagement in care services (standard-of-care control arm) or health department-initiated active re-engagement services (intervention arm)...
January 2023: Journal of the International AIDS Society
#15
Dengke Wang, Lizhen Zhao, Tianxuan Hao, Yang Du, Jianting Shen, Yiju Tang, Jiupeng Gong, Fan Li, Xiao Yan, Zehua Wang, Yu Fang
[This corrects the article DOI: 10.1021/acsomega.2c05188.].
November 29, 2022: ACS Omega
#16
JOURNAL ARTICLE
Marie-Laure Perrin, Sylvia M Bardet, Catherine Yardin, Sylvaine Durand Fontanier, Abdelkader Taibi
BACKGROUND: The histological responses (HRs) after systemic chemotherapy should be used to determine the optimal management of patients with peritoneal and liver metastasis from colorectal cancer (cPM, cLM), in curative intent. We aimed to compare HRs of cPM and cLM in metastatic mice model after chemotherapy. METHODS: Colon carcinoma CT26-luc cells were transplanted into syngeneic BALB/c mice by intraperitoneal (leading to cPM), intrasplenic (leading to cLM), or intraperitoneal + intrasplenic (leading to cPM cLM) injections and follow up using bioluminescence during 21 days...
November 18, 2022: European Journal of Surgical Oncology
#17
JOURNAL ARTICLE
Rebecca J Birch, Daniel Peckham, Henry M Wood, Philip Quirke, Rob Konstant-Hambling, Keith Brownlee, Rebecca Cosgriff, Genomics England Research Consortium, Nicholas Burr, Amy Downing
BACKGROUND: Studies have demonstrated a higher risk of developing colorectal cancer (CRC) in individuals with Cystic Fibrosis (CF), and also a potentially increased risk in carriers of cystic fibrosis transmembrane conductance regulator (CFTR) mutations. Life expectancy for those with CF is rising, increasing the number at risk of developing CRC. METHODS: The incidence of CRC amongst individuals with CF was calculated using data from CORECT-R and linked UK CF Registry and Secondary User Services (SUS) data...
October 14, 2022: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
#18
JOURNAL ARTICLE
James Yarmolinsky, Christopher I Amos, Rayjean J Hung, Victor Moreno, Kimberley Burrows, Karl Smith-Byrne, Joshua R Atkins, Paul Brennan, James D McKay, Richard M Martin, George Davey Smith
Deucravacitinib, a novel, selective inhibitor of TYK2 is currently under review at the FDA and EMA for treatment of moderate-to-severe plaque psoriasis. It is unclear whether recent safety concerns (ie, elevated rates of lung cancer and lymphoma) related to similar medications (ie, other JAK inhibitors) are shared with this novel TYK2 inhibitor. We used a partial loss-of-function variant in TYK2 (rs34536443), previously shown to protect against psoriasis and other autoimmune diseases, to evaluate the potential effect of therapeutic TYK2 inhibition on risk of lung cancer and non-Hodgkin lymphoma...
December 15, 2022: International Journal of Cancer. Journal International du Cancer
#19
Rebeca Martínez-Haya, Adrián A Heredia, Willber D Castro-Godoy, Luciana C Schmidt, M Luisa Marin, Juan E Argüello
No abstract text is available yet for this article.
December 17, 2021: Journal of Organic Chemistry
#20
JOURNAL ARTICLE
Aayah Nounu, Rebecca C Richmond, Isobel D Stewart, Praveen Surendran, Nicholas J Wareham, Adam Butterworth, Stephanie J Weinstein, Demetrius Albanes, John A Baron, John L Hopper, Jane C Figueiredo, Polly A Newcomb, Noralane M Lindor, Graham Casey, Elizabeth A Platz, Loïc Le Marchand, Cornelia M Ulrich, Christopher I Li, Fränzel J B van Dujinhoven, Andrea Gsur, Peter T Campbell, Víctor Moreno, Pavel Vodicka, Ludmila Vodickova, Efrat Amitay, Elizabeth Alwers, Jenny Chang-Claude, Lori C Sakoda, Martha L Slattery, Robert E Schoen, Marc J Gunter, Sergi Castellví-Bel, Hyeong-Rok Kim, Sun-Seog Kweon, Andrew T Chan, Li Li, Wei Zheng, D Timothy Bishop, Daniel D Buchanan, Graham G Giles, Stephen B Gruber, Gad Rennert, Zsofia K Stadler, Tabitha A Harrison, Yi Lin, Temitope O Keku, Michael O Woods, Clemens Schafmayer, Bethany Van Guelpen, Steven Gallinger, Heather Hampel, Sonja I Berndt, Paul D P Pharoah, Annika Lindblom, Alicja Wolk, Anna H Wu, Emily White, Ulrike Peters, David A Drew, Dominique Scherer, Justo Lorenzo Bermejo, Hermann Brenner, Michael Hoffmeister, Ann C Williams, Caroline L Relton
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls)...
November 21, 2021: Nutrients
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