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https://www.readbyqxmd.com/read/27920567/evaluation-of-bode-index-and-its-relationship-with-systemic-inflammation-mediated-by-proinflammatory-biomarkers-in-patients-with-copd
#1
Naushad Ahmad Khan, Mradul Kumar Daga, Istaq Ahmad, Govind Mawari, Suman Kumar, Naresh Kumar, Syed Akhter Husain
INTRODUCTION: BODE index, a multidimensional grading system which is based on Body mass index, airway Obstruction, Dyspnea scale, and Exercise capacity, has been increasingly used for the evaluation of chronic obstructive pulmonary disease (COPD). Many of the systemic manifestations of COPD are shown to be mediated by elevated levels of proinflammatory biomarkers. OBJECTIVE: We aimed to investigate the relationship between the BODE index, its components, disease severity, and proinflammatory biomarkers like C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27920519/outcomes-of-a-telemonitoring-based-program-telepoc-in-frequently-hospitalized-copd-patients
#2
Cristóbal Esteban, Javier Moraza, Milagros Iriberri, Urko Aguirre, Begoña Goiria, José M Quintana, Myriam Aburto, Alberto Capelastegui
BACKGROUND: The increasing prevalence of chronic diseases requires changes in health care delivery. In COPD, telemedicine appears to be a useful tool. Our objective was to evaluate the efficacy (in improving health care-resource use and clinical outcomes) of a telemonitoring-based program (telEPOC) in COPD patients with frequent hospitalizations. MATERIALS AND METHODS: We conducted a nonrandomized observational study in an intervention cohort of 119 patients (Galdakao-Usansolo Hospital) and a control cohort of 78 patients (Cruces Hospital), followed up for 2 years (ClinicalTrials...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27915458/acl-deficiency-and-varus-osteoarthritis-high-tibial-osteotomy-alone-or-combined-with-acl-reconstruction
#3
Julian Mehl, Jochen Paul, Matthias J Feucht, Gerrit Bode, Andreas B Imhoff, Norbert P Südkamp, Stefan Hinterwimmer
INTRODUCTION: This study investigates the mid- to long-term clinical and radiological outcome in patients with symptomatic varus osteoarthritis (OA) and deficiency of the anterior cruciate ligament (ACL) and analyzes whether there are differences between isolated high tibial osteotomy (HTO) or combined single-stage HTO and ACL reconstruction (ACLR). METHODS: 26 patients who underwent HTO alone (group 1) and 26 patients who underwent single-stage HTO and ACLR (group 2) because of varus OA and ACL deficiency were examined at a mean of 5...
December 3, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27874948/epicardial-fat-thickness-is-associated-with-severity-of-disease-in-patients-with-chronic-obstructive-pulmonary-disease
#4
K Kiraz, T Gökdeniz, E Kalaycıoglu, A Börekçi, S Akyol, A O Baykan, A Acele, S Karakoyun, T Seker, M Gür
OBJECTIVE: Cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD) and the BODE index is an important tool for the prognostic assessment of COPD patients. It is well known that epicardial fat thickness (EFT) is related to CVD. However, there are very few data about the relationship between EFT and BODE index. The aim of this study is to investigate the relationship between EFT and BODE index in patients with COPD. PATIENTS AND METHODS: We prospectively included 157 patients with COPD and 45 controls in the present study...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27771417/the-role-of-exhaled-nitric-oxide-in-patients-with-chronic-obstructive-pulmonary-disease-undergoing-laparotomy-surgery-the-noxious-study
#5
Helena Logotheti, Chryssa Pourzitaki, Georgia Tsaousi, Zoi Aidoni, Artemis Vekrakou, Amaniti Ekaterini, Konstantinos Gourgoulianis
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) has been associated with major perioperative morbidities or mortalities, especially in surgical patients receiving general anesthesia. The severity of the COPD and the degree of bronchial hyperreactivity can determine the perioperative anesthetic risk; therefore they have to be assessed by a thorough preoperative evaluation in order to give the rationale on which to decide for optimum anesthetic management. OBJECTIVE: Aim of the study was to assess the predictive applicability of exhaled Nitric Oxide (NO) in smoking surgical population with COPD, on the basis of morbidity and mortality...
October 19, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27695314/myocardial-performance-index-correlates-with-the-bode-index-and-affects-quality-of-life-in-copd-patients
#6
Daniela Graner Schuwartz Tannus-Silva, João Batista Masson-Silva, Lays Silva Ribeiro, Marcus Barreto Conde, Marcelo Fouad Rabahi
BACKGROUND AND OBJECTIVE: COPD, a systemic illness associated with the impairment of different organs, affects patient prognosis and quality of life. The aim of this study was to evaluate the association between right ventricle (RV) function, the BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index (a multifunctional scale for the assessment of mortality risk), and quality of life in patients with COPD. METHODS: A cross-sectional study was carried out in 107 outpatients presenting with stable COPD who underwent clinical assessment, spirometry, arterial blood gas analyses, a 6-minute walk test, electrocardiography, and echocardiogram and who responded to the Saint George's Respiratory Questionnaire (SGRQ)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27692154/determinants-of-exercise-induced-oxygen-desaturation-including-pulmonary-emphysema-in-copd-results-from-the-eclipse-study
#7
Vasileios Andrianopoulos, Bartolome R Celli, Frits M E Franssen, Victor M Pinto-Plata, Peter M A Calverley, Lowie E G W Vanfleteren, Ioannis Vogiatzis, Jørgen Vestbo, Alvar Agusti, Per S Bakke, Stephen I Rennard, William MacNee, Ruth Tal-Singer, Julie C Yates, Emiel F M Wouters, Martijn A Spruit
Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27684372/distribution-and-outcomes-of-a-phenotype-based-approach-to-guide-copd-management-results-from-the-chain-cohort
#8
Borja G Cosio, Joan B Soriano, Jose Luis López-Campos, Myriam Calle, Juan José Soler, Juan Pablo de-Torres, Jose Maria Marín, Cristina Martínez, Pilar de Lucas, Isabel Mir, Germán Peces-Barba, Nuria Feu-Collado, Ingrid Solanes, Inmaculada Alfageme
RATIONALE: The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. OBJECTIVE: We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes...
2016: PloS One
https://www.readbyqxmd.com/read/27627799/predicting-health-related-quality-of-life-in-patients-with-chronic-obstructive-pulmonary-disease-the-impact-of-age
#9
Alexandru Corlateanu, Victor Botnaru, Serghei Covantev, Silvia Dumitru, Nikolaos Siafakas
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity in the elderly population. COPD leads to a reduced health-related quality of life (HRQL), but the factors which contribute to this are not well understood. A better understanding of the factors which determine HRQL should lead to an improved care for such patients. OBJECTIVES: The purpose of this study was to investigate possible age-related differences in HRQL in a population of patients with a similar severity of obstruction...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27621870/correlation-of-cardiopulmonary-exercise-testing-parameters-with-quality-of-life-in-stable-copd-patients
#10
Mahsa Mirdamadi, Besharat Rahimi, Enayat Safavi, Hamidreza Abtahi, Soheil Peiman
BACKGROUND: The precise head to head relationships between Cardio-pulmonary exercise testing (CPET) parameters and patients' daily symptoms/activities and the disease social/emotional impact are less well defined. In this study, the correlation of COPD daily symptoms and quality of life [assessed by St. George's Respiratory Questionnaire (SGRQ)] and COPD severity index (BODE-index) with CPET parameters were investigated. METHODS: Symptom-limited CPET was performed in 37 consecutive COPD (GOLD I-III) subjects during non-exacerbation phase...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27573872/when-left-hemisphere-reading-is-compromised-comparing-reading-ability-in-participants-after-left-cerebral-hemispherectomy-and-participants-with-developmental-dyslexia
#11
Tami Katzir, Joanna A Christodoulou, Stella de Bode
OBJECTIVE: We investigated reading skills in individuals who have undergone left cerebral hemispherectomy and in readers with developmental dyslexia to understand diverse characteristics contributing to reading difficulty. Although dyslexia is a developmental disorder, left hemispherectomy requires that patients (re)establish the language process needed to perform the language-based tasks in the nondominant (right) hemisphere to become readers. METHODS: Participants with developmental dyslexia (DD; n = 11) and participants who had undergone left hemispherectomy (HEMI; n = 11) were matched on age and gender, and were compared on timed and untimed measures of single word and pseudo-word reading...
October 2016: Epilepsia
https://www.readbyqxmd.com/read/27549363/the-effect-of-fatigue-and-fatigue-intensity-on-exercise-tolerance-in-moderate-copd
#12
Khaled Al-Shair, Umme Kolsum, Dave Singh, Jørgen Vestbo
INTRODUCTION: Fatigue is one of the most disabling symptoms in COPD, but little is known about the impact of fatigue on functional disability. We explored the impact of fatigue and fatigue intensity on exercise tolerance after adjusting for other factors using multivariate analysis and compared it to that of dyspnoea. METHODS: A total of 119 patients with mainly moderate-severe stable COPD (38 % women, mean age 66 years) were enrolled. We used the Medical Research Council dyspnoea scores (MRC), Manchester COPD fatigue scale (MCFS) and its three dimensions, Borg scales for fatigue and dyspnoea, six-minute walk distance (6MWD), St George's Respiratory Questionnaire, the BODE index, and the Centre for Epidemiological Study on Depression scale (CES-D), and we measured spirometry, blood gases, systemic inflammatory markers and fat-free mass index (FFMI)...
December 2016: Lung
https://www.readbyqxmd.com/read/27496897/ccsp-g38a-polymorphism-environment-interactions-regulate-ccsp-levels-differentially-in-copd
#13
Lucie Knabe, Jessica Varilh, Anne Bergougnoux, Anne-Sophie Gamez, Jennifer Bonini, Alexandra Pommier, Aurélie Petit, Nicolas Molinari, Isabelle Vachier, Magali Taulan-Cadars, Arnaud Bourdin
Impaired airway homeostasis in chronic obstructive pulmonary disease (COPD) could be partly related to club cell secretory protein (CCSP) deficiency. We hypothesize that CCSP G38A polymorphism is involved and aim to examine the influence of the CCSP G38A polymorphism on CCSP transcription levels and its regulatory mechanisms. CCSP genotype and CCSP levels in serum and sputum were assessed in 66 subjects with stable COPD included in a 1-yr observational study. Forty-nine of them had an exacerbation. In an in vitro study, the impact on the CCSP promoter of 38G wild-type or 38A variant was assessed...
October 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27484106/static-and-functional-balance-in-individuals-with-copd-comparison-with-healthy-controls-and-differences-according-to-sex-and-disease-severity
#14
Larissa A de Castro, Laís Rg Ribeiro, Rafael Mesquita, Débora R de Carvalho, Josiane M Felcar, Myriam F Merli, Karen Bp Fernandes, Rubens A da Silva, Denilson C Teixeira, Martijn A Spruit, Fabio Pitta, Vanessa S Probst
BACKGROUND: Studies have shown that individuals with COPD have impaired body balance, probably caused by the disease's multisystemic manifestations plus age-related decline in balance, potentially increasing the risk of falling and its consequences. However, little is known about the profile of individuals with COPD who present balance impairments, especially related to sex and disease severity stages. The aim of this work was to compare static and functional balance between subjects with COPD and healthy controls and to check possible differences according to sex and degrees of disease severity...
August 2, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27452770/a-novel-spirometric-measure-identifies-mild-copd-unidentified-by-standard-criteria
#15
Asli Gorek Dilektasli, Janos Porszasz, Richard Casaburi, William W Stringer, Surya P Bhatt, Youngju Pak, Harry B Rossiter, George Washko, Peter J Castaldi, Raul San Jose Estepar, James E Hansen
BACKGROUND: In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV1 mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometric ratios, including the ratio of forced expiratory volume in 3 and 6 seconds (FEV3/FEV6), and small airways measures and gas trapping at quantitative chest CT scanning, and clinical outcomes in the Genetic Epidemiology of COPD (COPDGene) cohort...
November 2016: Chest
https://www.readbyqxmd.com/read/27402660/short-and-long-term-effects-of-concurrent-strength-and-hiit-training-in-octogenarian-copds
#16
Amelia Guadalupe-Grau, Susana Aznar-Laín, Asier Mañas, Juan Castellanos, Julián Alcázar, Ignacio Ara, Esmeralda Mata, Rosa Daimiel, Francisco José García-García
To investigate the short and long time effects of concurrent strength and high intensity interval training (HIIT) on octogenarian COPD patients, nine males (age=84.2 ± 2.8 yrs, BMI=29.3 ± 2.3), with low to severe COPD level (2.1 ± 1.5 BODE index), underwent a supervised 9-week strength and HIIT exercise program. Training had a significant (P<0.05) impact on senior fitness test scores (23-45%), 30m walking speed (from 1.29 ± 0.29 to 1.62 ± 0.33 m/s), leg and chest press 1RM (38 and 45% respectively), maximal isometric strength (30-35%), and 6-minute walking test (from 286...
August 24, 2016: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/27396907/effects-of-a-higher-dose-of-near-infrared-light-on-clinical-signs-and-neuroprotection-in-a-monkey-model-of-parkinson-s-disease
#17
Cécile Moro, Nabil El Massri, Fannie Darlot, Napoleon Torres, Claude Chabrol, Diane Agay, Vincent Auboiroux, Daniel M Johnstone, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid
We have reported previously that intracranial application of near-infrared light (NIr) - when delivered at the lower doses of 25J and 35J - reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether a higher NIr dose (125J) generated beneficial effects in the same MPTP monkey model (n=15). We implanted an NIr (670nm) optical fibre device within a midline region of the midbrain in macaque monkeys, close to the substantia nigra of both sides...
October 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27364317/chronic-obstructive-pulmonary-disease-prognostic-score-a-new-index
#18
Nobuyuki Horita, Vladimir Koblizek, Marek Plutinsky, Barbora Novotna, Karel Hejduk, Takeshi Kaneko
BACKGROUND: The evaluation of chronic obstructive pulmonary disease (COPD) has been shifting from spirometry to focus on the patients' overall health. Despite the existence of many COPD prognostic scales, there remains a large gap for improvement, in particular a scale that incorporates the current focus on overall health. METHODS: We proposed a new prognostic scale (the COPD Prognostic Score) through discussion among the authors based on published studies. Validation was retrospective, using data from the National Emphysema Treatment Trial...
June 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27212112/sialylated-galacto-oligosaccharides-and-2-fucosyllactose-reduce-necrotising-enterocolitis-in-neonatal-rats
#19
Chloe A Autran, Margriet H C Schoterman, Evelyn Jantscher-Krenn, Johannis P Kamerling, Lars Bode
Necrotising enterocolitis (NEC) is one of the most frequent and fatal intestinal disorders in preterm infants and has very limited treatment options. Breast-fed infants are at a 6-10-fold lower NEC risk than formula-fed infants, and we have previously shown that human milk oligosaccharides (HMO) improved survival and reduced pathology in a rat NEC model. The HMO disialyllacto-N-tetraose (DSLNT) was most effective, and sialylation was shown to be essential for its protective effect. Galacto-oligosaccharides (GOS), currently added to some infant formula, but not containing sialic acid, had no effect...
July 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27175646/lower-health-related-quality-of-life-in-polytrauma-patients-long-term-follow-up-after-over-5-years
#20
Jörn Zwingmann, Paul Hagelschuer, Elia Langenmair, Gerrit Bode, Georg Herget, Norbert P Südkamp, Thorsten Hammer
Although trauma-associated mortality has fallen in recent decades, and medical care has continued to improve in many fields, the quality of life after experiencing polytrauma has attracted little attention in the literature. This group of patients suffer from persisting physical disabilities. Moreover, they experience long-term social, emotional, and psychological effects that limit/lower considerably their quality of life.We analyzed retrospective data on 147 polytraumatized patients by administering written questionnaires and conducting face-to-face interviews 6 ± 0...
May 2016: Medicine (Baltimore)
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