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https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#1
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29445381/proteins-of-tnf-%C3%AE-and-il6-pathways-are-elevated-in-serum-of-type-1-diabetes-patients-with-microalbuminuria
#2
Sharad Purohit, Ashok Sharma, Wenbo Zhi, Shan Bai, Diane Hopkins, Leigh Steed, Bruce Bode, Stephen W Anderson, John Chip Reed, R Dennis Steed, Jin-Xiong She
Soluble cytokine receptors may play an important role in development of microalbuminuria (MA) in type-1 diabetes (T1D). In this study, we measured 12 soluble receptors and ligands from TNF-α/IL6/IL2 pathways in T1D patients with MA ( n = 89) and T1D patients without MA ( n = 483) participating in the PAGODA study. Twelve proteins in the sera from T1D patients with and without MA were measured using multiplex Luminex assays. Ten serum proteins (sTNFR1, sTNFR2, sIL2Rα, MMP2, sgp130, sVCAM1, sIL6R, SAA, CRP, and sICAM1) were significantly elevated in T1D patients with MA...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29428052/heart-score-and-stress-test-emergency-department-bayesian-decision-scheme-results-from-the-acute-care-diagnostic-collaboration
#3
Naureen Farook, L Cochon, A D Bode, B P Langer, A A Baez
BACKGROUND: Accurate identification of patients at risk of major adverse cardiac events (MACE) places a substantial burden on emergency physicians (EPs). Bayesian nomogram for risk stratification in low- to intermediate-risk cardiovascular patients has not been investigated previously. OBJECTIVE: The objective of this study was to develop a comparative diagnostic model using Bayesian statistics for exercise treadmill test (ETT) and stress echocardiogram (ECHO) to calculate post-test diagnostic risk of MACE using HEART (history, electrocardiogram, age, risk factors, and troponin) risk score as predictor of pretest probability...
February 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29425352/women-and-men-together-in-recruit-training
#4
Geoffrey J Orme, E James Kehoe
Introduction: Although men and women recruits to the Australian Army have trained in mixed-gender platoons since 1995, restrictions on women joining the combat arms were only removed in 2016. As part of a longitudinal study starting with recruit training, this article examined recruit records collected before 2016 with the aims of delineating (1) the relative performance of women versus men in mixed-gender platoons and (2) the relative performance of men in mixed-gender platoons versus all-male platoons...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29413721/isoflurane-or-propofol-sedation-in-patients-with-targeted-temperature-management-after-cardiopulmonary-resuscitation-a-single-center-study
#5
Dawid Leander Staudacher, Sarah-Kristin Hamilton, Daniel Duerschmied, Paul Marc Biever, Manfred Zehender, Christoph Bode, Tobias Wengenmayer
PROPOSE: Targeted temperature management improves outcomes in comatose patients after cardiac arrest. Short lasting sedatives might enable rapid awakening after targeted temperature management and therefore early prognostication and extubation. Aim of the present study was to compare sedation with volatile isoflurane to intravenous propofol. MATERIALS AND METHODS: All patients after cardiopulmonary resuscitation undergoing targeted temperature management treated between 01/2014 and 02/2017 at a single tertiary referral hospital were screened...
February 2, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29322375/predictors-of-short-term-lama-ineffectiveness-in-treatment-na%C3%A3-ve-patients-with-moderate-to-severe-copd
#6
Vladimir Fijačko, Marina Labor, Mirjana Fijačko, Sanda Škrinjarić-Cincar, Slavica Labor, Iva Dumbović Dubravčić, Tatjana Bačun, Aleksandar Včev, Sanja Popović-Grle, Davor Plavec
BACKGROUND: No specific (only subgroup) recommendations for the use of long-acting muscarinic antagonists in chronic obstructive pulmonary disease (COPD) exist. The aim of this exploratory hypothesis generating study was to assess whether different phenotypic/endotypic characteristics could be determinants of the short-term ineffectiveness of the initial tiotropium bromide monotherapy in treatment naïve moderate to severe COPD patients. METHODS: A total of 51 consecutively recruited COPD patients were followed for 3 months after the initial evaluation and prescribed initial treatment (tiotropium)...
January 10, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29319032/study-of-inflammatory-markers-and-bode-index-in-chronic-obstructive-pulmonary-disease
#7
Priti Lokesh Meshram, Shivprasad N Shinde, Nagsen N Ramraje, Rohit R Hegde
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by progressive airflow limitation and associated with enhanced chronic inflammatory response of the airways to a variety of noxious stimuli. The current concept of COPD, however, extends beyond the respiratory system to include a variety of extrapulmonary manifestations which includes raised inflammatory markers. METHODS: This was a single, center observational open-labeled case-controlled study which included fifty patients of diagnosed COPD and 50 age- and gender-matched controls...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29319031/association-of-comorbid-anxiety-and-depression-with-chronic-obstructive-pulmonary-disease
#8
Ruchi Dua, Anindya Das, Abhishek Kumar, Sandeep Kumar, Mayank Mishra, Kapil Sharma
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a disease with known systemic manifestations including psychiatric comorbidities most commonly being depression and/or anxiety. Studies regarding the association of these psychiatric comorbidities in terms of symptom scores, spirometric variables, and hospitalizations among patients of COPD are lacking, especially in India. MATERIALS AND METHODS: One hundred and twenty-eight patients of COPD attending the Outpatient Department of AIIMS Rishikesh, and fulfilling inclusion criteria were screened by Hospital Anxiety and Depression Scale, and those who scored above the cutoff underwent psychiatric evaluation using the International Classification of Diseases, Tenth Edition Diagnostic Criteria for Research for confirmation of their diagnosis...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29169250/clinical-effects-of-cognitive-impairment-in-patients-with-chronic-obstructive-pulmonary-disease
#9
Esra Ertan Yazar, Senay Aydin, Gulsah Gunluoglu, Sadettin Kamat, Adil Can Gungen, Pinar Yildiz
The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. The Brody's Instrumental Activities of Daily Living (IADL) Questionnaire; COPD assessment test (CAT); body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE); and Charlson comorbidity index were assessed...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29099607/comparison-of-2017-and-2015-global-initiative-for-obstructive-lung-disease-impact-on-grouping-and-outcomes
#10
Carlos Cabrera López, Ciro Casanova Macario, José María Marín Trigo, Juan P de-Torres, Rebeca Sicilia Torres, Jesús María González, Francesca Polverino, Miguel Divo, Victor Pinto Plata, Javier J Zulueta, Bartolomé Celli
INTRODUCTION: The GOLD document has modified the grading system directing pharmacotherapy. But how this relates to the previous one of 2015 and to comorbidities, hospitalizations and mortality risk is unknown. METHODS: We prospectively enrolled and followed for a mean of 5 years, 819 COPD patients (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV1%), dyspnea score (mMRC), ambulatory and hospital exacerbations, the BODE and Charlson indexes...
November 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29054348/survival-of-lung-transplant-candidates-with-copd-bode-score-reconsidered
#11
Robert M Reed, Howard J Cabral, Mark T Dransfield, Michael Eberlein, Christian A Merlo, Matthew J Mulligan, Giora Netzer, Pablo G Sanchez, Steven M Scharf, Don D Sin, Bartholome R Celli
BACKGROUND: The BMI, obstruction, dyspnea, and exercise capacity (BODE) score is used to inform prognostic considerations for lung transplantation for COPD, but it has not been validated in this context. A large proportion of mortality in COPD is attributable to comorbidities that could preclude transplant candidacy. We hypothesized that patients with COPD who are selected as transplant candidates experience better survival than traditional interpretation of BODE scores might indicate...
October 17, 2017: Chest
https://www.readbyqxmd.com/read/28987858/-effectiveness-of-an-educational-program-for-respiratory-rehabilitation-of-chronic-obstructive-pulmonary-disease-patients-in-primary-care-in-improving-the-quality-of-life-symptoms-and-clinical-risk
#12
Cristina Blánquez Moreno, Cristina Colungo Francia, M Carme Alvira Balada, Belchin Kostov, Luis González-de Paz, Antoni Sisó-Almirall
AIM: To determine the impact of an educational program to improve the management of chronic obstructive pulmonary disease (COPD) that contributes to an increase of the quality of life, exercise capacity, level of dyspnoea, and clinical risk. DESIGN: Intervention study without controls. LOCATION: Primary Healthcare Centre. PARTICIPANTS: 193 patients with COPD were invited, 73 accepted and 55 participated in the educational program...
October 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28975376/customized-post-operative-alignment-improves-clinical-outcome-following-medial-open-wedge-osteotomy
#13
Lisa Hohloch, Suchung Kim, Julian Mehl, Jörn Zwingmann, Matthias J Feucht, Helge Eberbach, Philipp Niemeyer, Norbert Südkamp, Gerrit Bode
PURPOSE: High tibial osteotomy (HTO) has gained more importance in the treatment of cartilage damage or osteoarthritis of the medial compartment with concurrent varus deformity. Concerning the extent of axis correction, various different views exist. The aim of this study was to evaluate the effect of the size of axis correction on functional outcome in patients undergoing a valgus HTO. METHODS: From 2005 to 2013, 156 patients with an underlying varus deformity and cartilage damages or unicompartimental osteoarthritis of the medial compartment were treated by HTO...
October 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28947025/patient-related-outcomes-bode-pro-bode-a-composite-index-incorporating-health-utilization-resources-predicts-mortality-and-economic-cost-of-copd-in-real-life
#14
R W Dal Negro, B R Celli
Multidimensional scores were proposed for defining COPD outcomes, but without any incorporation of the economic COPD cost to clinical indices. AIM: using mortality as an outcome, the hypothesis that adding total health care cost to the BODE index would better predict mortality in COPD was investigated. METHODS: 275 COPD patients were surveyed. Anthropometrics, lung function, the BODE and the Charlson Comorbidity Index were determined. History of exacerbations, ER visits, hospitalizations and mortality were also determined over the next three years, being their rates graded and added to the BODE index according to a simple algorithm...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28918523/focal-metallic-inlay-resurfacing-prosthesis-for-the-treatment-of-localized-cartilage-defects-of-the-femoral-condyles-a-systematic-review-of-clinical-studies
#15
REVIEW
Andreas Fuchs, Helge Eberbach, Kaywan Izadpanah, Gerrit Bode, Norbert P Südkamp, Matthias J Feucht
PURPOSE: To systematically review the results of focal metallic inlay resurfacing prosthesis for the treatment of isolated cartilage defects of the femoral condyles. METHODS: A systematic electronic search of the PubMed database and the Cochrane Library was performed in April 2017 to identify studies that reported clinical or radiographic outcome of focal metallic inlay resurfacing prosthesis for the treatment of isolated cartilage defects of the femoral condyles...
September 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28893843/timing-of-angiography-and-outcomes-in-high-risk-patients-with-non-st-segment-elevation-myocardial-infarction-managed-invasively-insights-from-the-tao-trial
#16
Pierre Deharo, Gregory Ducrocq, Christoph Bode, Marc Cohen, Thomas Cuisset, Shamir Mehta, Charles V Pollack, Stephen D Wiviott, Yedid Elbez, Marc Sabatine, P Gabriel Steg
Background -In patients with non ST-elevation myocardial infarction (NSTEMI) and Global Registry of Acute Coronary Events (GRACE) score >140, coronary angiography (CAG) is recommended by European and American guidelines within 24h. We sought to study the association of a "very early" (i.e. ≤12h), early (12-24h) and delayed (>24h) CAG in NSTEMI with GRACE score >140 with ischemic outcomes. Methods -The Treatment of Acute coronary syndrome with Otamixaban (TAO) trial randomized patients with NSTEMI and CAG scheduled within 72h to heparin plus eptifibatide versus otamixaban...
September 11, 2017: Circulation
https://www.readbyqxmd.com/read/28885054/a-multicenter-randomized-controlled-trial-of-zephyr-endobronchial-valve-treatment-in-heterogeneous-emphysema-transform
#17
RANDOMIZED CONTROLLED TRIAL
Samuel V Kemp, Dirk-Jan Slebos, Alan Kirk, Malgorzata Kornaszewska, Kris Carron, Lars Ek, Gustav Broman, Gunnar Hillerdal, Herve Mal, Christophe Pison, Amandine Briault, Nicola Downer, Kaid Darwiche, Jagan Rao, Ralf-Harto Hübner, Christof Ruwwe-Glosenkamp, Valéry Trosini-Desert, Ralf Eberhardt, Felix J Herth, Eric Derom, Thomas Malfait, Pallav L Shah, Justin L Garner, Nick H Ten Hacken, Hazem Fallouh, Sylvie Leroy, Charles H Marquette
RATIONALE: Single-center randomized controlled trials of the Zephyr endobronchial valve (EBV) treatment have demonstrated benefit in severe heterogeneous emphysema. This is the first multicenter study evaluating this treatment approach. OBJECTIVES: To evaluate the efficacy and safety of Zephyr EBVs in patients with heterogeneous emphysema and absence of collateral ventilation. METHODS: This was a prospective, multicenter 2:1 randomized controlled trial of EBVs plus standard of care or standard of care alone (SoC)...
December 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28789628/patellar-tendinopathy-in-young-elite-soccer-clinical-and-sonographical-analysis-of-a-german-elite-soccer-academy
#18
Gerrit Bode, Thorsten Hammer, N Karvouniaris, M J Feucht, L Konstantinidis, N P Südkamp, A Hirschmüller
BACKGROUND: The prevalence of patellar tendinopathy is elevated in elite soccer compared to less explosive sports. While the burden of training hours and load is comparably high in youth elite players (age < 23 years), little is known about the prevalence of patellar tendinopathy at this age. There is only little data available on the influence of age, the amount of training, the position on the field, as well as muscular strength, range of motion, or sonographical findings in this age group...
August 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28707983/signs-of-gas-trapping-in-normal-lung-density-regions-in-smokers
#19
Sandeep Bodduluri, Joseph M Reinhardt, Eric A Hoffman, John D Newell, Hrudaya Nath, Mark T Dransfield, Surya P Bhatt
RATIONALE: A substantial proportion of subjects without overt airflow obstruction have significant respiratory morbidity and structural abnormalities on computed tomography (CT). Whether regions of the lung that appear normal using traditional CT criteria have mild disease is not known. OBJECTIVE: To identity subthreshold structural disease in normal appearing lung regions in smokers. METHODS: We analyzed 8034 subjects with complete inspiratory and expiratory CT data participating in COPDGene including 103 lifetime non-smokers...
July 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28655179/to-err-is-perfectly-human-behavioural-and-neural-correlates-of-error-processing-and-perfectionism
#20
Antonia Barke, Stefan Bode, Peter Dechent, Carsten Schmidt-Samoa, Christina Van Heer, Jutta Stahl
The attitude towards one's own imperfection strongly varies between individuals. Here, we investigated variations in error-related activity depending on two sub-traits of perfectionism, Personal Standard Perfectionism (PSP) and Evaluative Concern Perfectionism (ECP) in a large scale functional magnetic resonance imaging study (N = 75) using a digit-flanker task. Participants with higher PSP scores showed both more post-error slowing and more neural activity in the medial-frontal gyrus including anterior cingulate cortex after errors...
October 1, 2017: Social Cognitive and Affective Neuroscience
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