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https://www.readbyqxmd.com/read/28987858/-effectiveness-of-an-educational-program-for-respiratory-rehabilitation-of-chronic-obstructive-pulmonary-disease-patients-in-primary-care-in-improving-the-quality-of-life-symptoms-and-clinical-risk
#1
Cristina Blánquez Moreno, Cristina Colungo Francia, M Carme Alvira Balada, Belchin Kostov, Luis González-de Paz, Antoni Sisó-Almirall
AIM: To determine the impact of an educational program to improve the management of chronic obstructive pulmonary disease (COPD) that contributes to an increase of the quality of life, exercise capacity, level of dyspnoea, and clinical risk. DESIGN: Intervention study without controls. LOCATION: Primary Healthcare Centre. PARTICIPANTS: 193 patients with COPD were invited, 73 accepted and 55 participated in the educational program...
October 4, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28975376/customized-post-operative-alignment-improves-clinical-outcome-following-medial-open-wedge-osteotomy
#2
Lisa Hohloch, Suchung Kim, Julian Mehl, Jörn Zwingmann, Matthias J Feucht, Helge Eberbach, Philipp Niemeyer, Norbert Südkamp, Gerrit Bode
PURPOSE: High tibial osteotomy (HTO) has gained more importance in the treatment of cartilage damage or osteoarthritis of the medial compartment with concurrent varus deformity. Concerning the extent of axis correction, various different views exist. The aim of this study was to evaluate the effect of the size of axis correction on functional outcome in patients undergoing a valgus HTO. METHODS: From 2005 to 2013, 156 patients with an underlying varus deformity and cartilage damages or unicompartimental osteoarthritis of the medial compartment were treated by HTO...
October 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28947025/patient-related-outcomes-bode-pro-bode-a-composite-index-incorporating-health-utilization-resources-predicts-mortality-and-economic-cost-of-copd-in-real-life
#3
R W Dal Negro, B R Celli
Multidimensional scores were proposed for defining COPD outcomes, but without any incorporation of the economic COPD cost to clinical indices. AIM: using mortality as an outcome, the hypothesis that adding total health care cost to the BODE index would better predict mortality in COPD was investigated. METHODS: 275 COPD patients were surveyed. Anthropometrics, lung function, the BODE and the Charlson Comorbidity Index were determined. History of exacerbations, ER visits, hospitalizations and mortality were also determined over the next three years, being their rates graded and added to the BODE index according to a simple algorithm...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28918523/focal-metallic-inlay-resurfacing-prosthesis-for-the-treatment-of-localized-cartilage-defects-of-the-femoral-condyles-a-systematic-review-of-clinical-studies
#4
REVIEW
Andreas Fuchs, Helge Eberbach, Kaywan Izadpanah, Gerrit Bode, Norbert P Südkamp, Matthias J Feucht
PURPOSE: To systematically review the results of focal metallic inlay resurfacing prosthesis for the treatment of isolated cartilage defects of the femoral condyles. METHODS: A systematic electronic search of the PubMed database and the Cochrane Library was performed in April 2017 to identify studies that reported clinical or radiographic outcome of focal metallic inlay resurfacing prosthesis for the treatment of isolated cartilage defects of the femoral condyles...
September 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28893843/timing-of-angiography-and-outcomes-in-high-risk-patients-with-non-st-segment-elevation-myocardial-infarction-managed-invasively-insights-from-the-tao-trial
#5
Pierre Deharo, Gregory Ducrocq, Christoph Bode, Marc Cohen, Thomas Cuisset, Shamir Mehta, Charles V Pollack, Stephen D Wiviott, Yedid Elbez, Marc Sabatine, P Gabriel Steg
Background -In patients with non ST-elevation myocardial infarction (NSTEMI) and Global Registry of Acute Coronary Events (GRACE) score >140, coronary angiography (CAG) is recommended by European and American guidelines within 24h. We sought to study the association of a "very early" (i.e. ≤12h), early (12-24h) and delayed (>24h) CAG in NSTEMI with GRACE score >140 with ischemic outcomes. Methods -The Treatment of Acute coronary syndrome with Otamixaban (TAO) trial randomized patients with NSTEMI and CAG scheduled within 72h to heparin plus eptifibatide versus otamixaban...
September 11, 2017: Circulation
https://www.readbyqxmd.com/read/28885054/a-multicenter-rct-of-zephyr%C3%A2-endobronchial-valve-treatment-in-heterogeneous-emphysema-transform
#6
Samuel V Kemp, Dirk-Jan Slebos, Alan Kirk, Malgorzata Kornaszewska, Kris Carron, Lars Ek, Gustav Broman, Gunnar Hillerdal, Herve Mal, Christophe Pison, Amandine Briault, Nicola Downer, Kaid Darwiche, Jagan Rao, Ralf-Harto Hübner, Christof Ruwwe-Glosenkamp, Valéry Trosini-Desert, Ralf Eberhardt, Felix J Herth, Eric Derom, Thomas Malfait, Pallav L Shah, Justin L Garner, Nick H Ten Hacken, Hazem Fallouh, Sylvie Leroy, Charles H Marquette
RATIONALE: Single-center RCTs of Zephyr Endobronchial Valve (EBV) treatment have demonstrated benefit in severe heterogeneous emphysema. This is the first multicenter study evaluating this treatment approach. OBJECTIVES: To evaluate the efficacy and safety of Zephyr EBVs in patients with heterogeneous emphysema and absence of collateral ventilation. METHODS: Prospective, multicenter 2:1 RCT of EBVs plus standard of care or standard of care (SoC) alone...
September 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28789628/patellar-tendinopathy-in-young-elite-soccer-clinical-and-sonographical-analysis-of-a-german-elite-soccer-academy
#7
Gerrit Bode, Thorsten Hammer, N Karvouniaris, M J Feucht, L Konstantinidis, N P Südkamp, A Hirschmüller
BACKGROUND: The prevalence of patellar tendinopathy is elevated in elite soccer compared to less explosive sports. While the burden of training hours and load is comparably high in youth elite players (age < 23 years), little is known about the prevalence of patellar tendinopathy at this age. There is only little data available on the influence of age, the amount of training, the position on the field, as well as muscular strength, range of motion, or sonographical findings in this age group...
August 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28707983/signs-of-gas-trapping-in-normal-lung-density-regions-in-smokers
#8
Sandeep Bodduluri, Joseph M Reinhardt, Eric A Hoffman, John D Newell, Hrudaya Nath, Mark T Dransfield, Surya P Bhatt
RATIONALE: A substantial proportion of subjects without overt airflow obstruction have significant respiratory morbidity and structural abnormalities on computed tomography (CT). Whether regions of the lung that appear normal using traditional CT criteria have mild disease is not known. OBJECTIVE: To identity subthreshold structural disease in normal appearing lung regions in smokers. METHODS: We analyzed 8034 subjects with complete inspiratory and expiratory CT data participating in COPDGene including 103 lifetime non-smokers...
July 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28655179/to-err-is-perfectly-human-behavioural-and-neural-correlates-of-error-processing-and-perfectionism
#9
Antonia Barke, Stefan Bode, Peter Dechent, Carsten Schmidt-Samoa, Christina Van Heer, Jutta Stahl
The attitude towards one's own imperfection strongly varies between individuals. Here, we investigated variations in error-related activity depending on two sub-traits of perfectionism, Personal Standard Perfectionism (PSP) and Evaluative Concern Perfectionism (ECP) in a large scale functional magnetic resonance imaging study (N = 75) using a digit-flanker task. Participants with higher PSP scores showed both more post-error slowing and more neural activity in the medial-frontal gyrus including anterior cingulate cortex after errors...
October 1, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28637497/influence-of-low-flow-time-on-survival-after-extracorporeal-cardiopulmonary-resuscitation-ecpr
#10
Tobias Wengenmayer, Stephan Rombach, Florian Ramshorn, Paul Biever, Christoph Bode, Daniel Duerschmied, Dawid L Staudacher
BACKGROUND: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) support under extracorporeal cardiopulmonary resuscitation (eCPR) is the last option and may be offered to selected patients. Several factors predict outcome in these patients, including initial heart rhythm, comorbidities, and bystander cardiopulmonary resuscitation (CPR). We evaluated outcomes of all VA-ECMO patients treated within the last 5 years at our center in respect to low-flow duration during CPR. METHODS: We report retrospective registry data on all patients with eCPR treated at a university hospital between October 2010 and May 2016...
June 22, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28489783/clinical-significance-and-prognostic-value-of-triosephosphate-isomerase-expression-in-gastric-cancer
#11
Tingting Chen, Zhigang Huang, Yunxiao Tian, Bode Lin, Rongwei He, Haiwei Wang, Ping Ouyang, Haoqin Chen, Lili Wu
Triosephosphate isomerase (TPI) is highly expressed in many human cancers and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and prognostic value in gastric cancer (GC) are not yet well defined. The aim of the present work was to evaluate TPI expression in GC tissue and its prognostic value in GC patients.TPI expression was analyzed in 92 primary GC tissues and 80 adjacent normal mucosa tissues from GC patients undergoing gastrectomy by immunohistochemical analysis of tissue microarrays (TMAs)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28476758/poststroke-epilepsy-in-long-term-survivors-of-primary-intracerebral-hemorrhage
#12
Anna-Maija Lahti, Pertti Saloheimo, Juha Huhtakangas, Henrik Salminen, Seppo Juvela, Michaela K Bode, Matti Hillbom, Sami Tetri
OBJECTIVE: To identify the incidence and predisposing factors for development of poststroke epilepsy (PSE) after primary intracerebral hemorrhage (PICH) during a long-term follow-up. METHODS: We performed a retrospective study of patients who had had their first-ever PICH between January 1993 and January 2008 in Northern Ostrobothnia, Finland, and who survived for at least 3 months. These patients were followed up for PSE. The associations between PSE occurrence and sex, age, Glasgow Coma Scale (GCS) score on admission, hematoma location and volume, early seizures, and other possible risk factors for PSE were assessed using the Cox proportional hazards regression model...
June 6, 2017: Neurology
https://www.readbyqxmd.com/read/28463992/small-molecule-inhibitors-of-mesotrypsin-from-a-structure-based-docking-screen
#13
Olumide Kayode, Zunnan Huang, Alexei S Soares, Thomas R Caulfield, Zigang Dong, Ann M Bode, Evette S Radisky
PRSS3/mesotrypsin is an atypical isoform of trypsin, the upregulation of which has been implicated in promoting tumor progression. To date there are no mesotrypsin-selective pharmacological inhibitors which could serve as tools for deciphering the pathological role of this enzyme, and could potentially form the basis for novel therapeutic strategies targeting mesotrypsin. A virtual screen of the Natural Product Database (NPD) and Food and Drug Administration (FDA) approved Drug Database was conducted by high-throughput molecular docking utilizing crystal structures of mesotrypsin...
2017: PloS One
https://www.readbyqxmd.com/read/28444072/chronic-obstructive-pulmonary-disease-exacerbation-in-the-intensive-care-unit-clinical-functional-and-quality-of-life-at-discharge-and-3-months-of-follow-up
#14
Renata Cristina Teixeira Pinto Viana, Mariangela Pimentel Pincelli, Emílio Pizzichini, André Pacheco Silva, Joice Manes, Tatiana Dias Marconi, Leila John Marques Steidle
Objective: The purpose of this study was to evaluate the clinical/functional aspects and quality of life of chronic obstructive pulmonary disease patients who were discharged after an intensive care unit admission for acute respiratory failure. Methods: This prospective study included chronic obstructive pulmonary disease patients who were admitted to two intensive care units between December of 2010 and August of 2011 and evaluated over three visits after discharge...
January 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28270168/towards-a-cardiac-allocation-score-a-retrospective-calculation-for-73-patients-from-a-german-transplant-center
#15
Sebastian Claes, Michael Berchtold-Herz, Qian Zhou, Georg Trummer, Matthias Bock, Andreas Zirlik, Friedhelm Beyersdorf, Christoph Bode, Sebastian Grundmann
BACKGROUND: Due to a growing discrepancy between the transplant waiting list and decreasing numbers of available donor hearts, cardiac transplantation rates in Germany have been declining in the past years. Currently, patients on the waiting list are prioritized by medical urgency and waiting time and therefore a majority of all cardiac transplants is performed in very ill patients. Recently, a different allocation algorithm was proposed that included predicted post-transplant survival as a parameter for organ allocation...
March 7, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28244013/impact-of-airflow-limitation-in-chronic-heart-failure
#16
S Bektas, F M E Franssen, V van Empel, N Uszko-Lencer, J Boyne, C Knackstedt, H P Brunner-La Rocca
BACKGROUND: Comorbidities are common in chronic heart failure (HF) patients, but diagnoses are often not based on objective testing. Chronic obstructive pulmonary disease (COPD) is an important comorbidity and often neglected because of shared symptoms and risk factors. Precise prevalence and consequences are not well known. Therefore, we investigated prevalence, pulmonary treatment, symptoms and quality of life (QOL) of COPD in patients with chronic HF. METHODS: 205 patients with stable HF for at least 1 month, aged above 50 years, were included from our outpatient cardiology clinic, irrespective of left ventricular ejection fraction...
May 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28243702/sport-specific-outcomes-after-isolated-meniscal-repair-a-systematic-review
#17
REVIEW
Helge Eberbach, Jörn Zwingmann, Lisa Hohloch, Gerrit Bode, Dirk Maier, Philipp Niemeyer, Norbert P Südkamp, Matthias J Feucht
PURPOSE: The purpose of this systematic review was to assess sport-specific outcomes after repair of isolated meniscal tears. METHODS: A systematic electronic search of the MEDLINE and Cochrane database was performed in May 2016 to identify studies that reported sport-specific outcomes after isolated meniscal repair. Included studies were abstracted regarding study characteristics, patient demographics, surgical technique, rehabilitation, and outcome measures. The methodological quality of the included studies was assessed with the Coleman Methodology Score (CMS)...
February 27, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28186686/combined-bone-marrow-derived-mesenchymal-stromal-cell-therapy-and-one-way-endobronchial-valve-placement-in-patients-with-pulmonary-emphysema-a-phase-i-clinical-trial
#18
Hugo Goulart de Oliveira, Fernanda Ferreira Cruz, Mariana Alves Antunes, Amarilio Vieira de Macedo Neto, Guilherme Augusto Oliveira, Fabio Munhoz Svartman, Tamara Borgonovo, Carmen Lucia Kuniyoshi Rebelatto, Daniel J Weiss, Paulo Roberto Slud Brofman, Marcelo Marcos Morales, José Roberto Lapa E Silva, Patricia Rieken Macedo Rocco
One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients. However, local inflammation may result and can contribute to worsening of clinical status in these patients. We hypothesized that combined EBV insertion and intrabronchial administration of mesenchymal stromal cells (MSCs) would decrease the inflammatory process, thus mitigating EBV complications in severe COPD patients. This initial study sought to investigate the safety of this approach...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28138233/birmingham-copd-cohort-a-cross-sectional-analysis-of-the-factors-associated-with-the-likelihood-of-being-in-paid-employment-among-people-with-copd
#19
COMPARATIVE STUDY
Kiran K Rai, Rachel E Jordan, W Stanley Siebert, Steven S Sadhra, David A Fitzmaurice, Alice J Sitch, Jon G Ayres, Peymané Adab
BACKGROUND: Employment rates among those with chronic obstructive pulmonary disease (COPD) are lower than those without COPD, but little is known about the factors that affect COPD patients' ability to work. METHODS: Multivariable analysis of the Birmingham COPD Cohort Study baseline data was used to assess the associations between lifestyle, clinical, and occupational characteristics and likelihood of being in paid employment among working-age COPD patients. RESULTS: In total, 608 of 1,889 COPD participants were of working age, of whom 248 (40...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28130755/prevention-and-therapy-of-pediatric-emergence-delirium-a-national-survey
#20
Christopher Huett, Torsten Baehner, Felix Erdfelder, Claudia Hoehne, Christian Bode, Andreas Hoeft, Richard K Ellerkmann
INTRODUCTION: Although pediatric emergence delirium (ED) is common, preventive and therapeutic pharmacological treatment is the matter of an international controversial discussion and evidence on different options is partially vague. OBJECTIVE: We therefore examined clinical routine in prevention strategies and postoperative therapy of ED with respect to clinical experience in pediatric anesthesia. METHODS: A web-based survey was developed investigating routine management (prevention and treatment) of ED, facility structure, and patient population...
April 2017: Paediatric Drugs
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