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https://www.readbyqxmd.com/read/28885871/using-the-virtual-world-of-second-life-in-veterinary-medicine-student-and-faculty-perceptions
#1
Mary M Pereira, Elpida Artemiou, Dee McGonigle, Anne Conan, Fortune Sithole, Kathleen Yvorchuk-St Jean
Virtual worlds are emerging technologies that can enhance student learning by encouraging active participation through simulation in immersive environments. At Ross University School of Veterinary Medicine (RUSVM), the virtual world of Second Life was piloted as an educational platform for first-semester students to practice clinical reasoning in a simulated veterinary clinical setting. Under the supervision of one facilitator, four groups of nine students met three times to process a clinical case using Second Life...
September 8, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28851841/backbone-cyclization-of-analgesic-conotoxin-gexiva-facilitates-direct-folding-of-the-ribbon-isomer
#2
Xiaosa Wu, Yen-Hua Huang, Quentin Kaas, Peta J Harvey, Conan K Wang, Han-Shen Tae, David J Adams, David J Craik
Conotoxin GeXIVA inhibits the α9α10 nicotinic acetylcholine receptor (nAChR) and is analgesic in animal models of pain. α-conotoxins have four cysteines, which can have three possible disulfide connectivities: globular (CysI-CysIII and CysII-CysIV); ribbon (CysI-CysIV and CysII-CysIII) or bead (CysI-CysII and CysIII-CysIV). Native α-conotoxins preferably adopt the globular connectivity, and previous studies of α-conotoxins have focused on the globular isomers as the ribbon and bead isomers typically have lower potency at nAChRs than the globular form...
August 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28783751/animal-related-factors-associated-with-moderate-to-severe-diarrhea-in-children-younger-than-five-years-in-western-kenya-a-matched-case-control-study
#3
MULTICENTER STUDY
Anne Conan, Ciara E O'Reilly, Eric Ogola, J Benjamin Ochieng, Anna J Blackstock, Richard Omore, Linus Ochieng, Fenny Moke, Michele B Parsons, Lihua Xiao, Dawn Roellig, Tamer H Farag, James P Nataro, Karen L Kotloff, Myron M Levine, Eric D Mintz, Robert F Breiman, Sarah Cleaveland, Darryn L Knobel
BACKGROUND: Diarrheal disease remains among the leading causes of global mortality in children younger than 5 years. Exposure to domestic animals may be a risk factor for diarrheal disease. The objectives of this study were to identify animal-related exposures associated with cases of moderate-to-severe diarrhea (MSD) in children in rural western Kenya, and to identify the major zoonotic enteric pathogens present in domestic animals residing in the homesteads of case and control children...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28782434/high-leptospira-seroprevalence-in-captive-and-wild-caught-vervet-monkeys-chlorocebus-sabeus-on-the-caribbean-island-of-saint-kitts
#4
Sreekumari Rajeev, Anne Conan, Nicola Pratt, Amy Beierschmitt, Roberta Palmour
Leptospirosis is a zoonotic disease of global importance. Very little information is available on Leptospira infection in nonhuman primates. We report herein a high seroprevalence (49.4%; 95% confidence interval: 41.6-57.2%) to Leptospira serovars in vervet monkeys ( Chlorocebus sabeus) on the Caribbean island of Saint Kitts. Monkeys bred in captivity ( n = 81) had a significantly higher seroprevalence compared to wild-caught monkeys ( n = 81; p < 0.05). Seroprevalence to serovar Bataviae was significantly higher in monkeys bred in captivity and was higher to serovar Bratislava in wild-caught monkeys ( p < 0...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28751756/knowledge-or-noise-making-sense-of-general-practitioners-and-consultant-use-of-2-week-wait-referrals-for-suspected-cancer
#5
Conan Donnelly, Nigel Hart, Alan David McCrorie, Lesley Anderson, Michael Donnelly, Peter Murchie, Anna Gavin
BACKGROUND: Early diagnosis and treatment of cancer is the goal of the 2-week-wait referral pathway (2WW). Variation exists between General Practice use of 2WW and rates of consultant reprioritisation of GP referral from routine to 2WW (Consultant Upgrade). We investigated variation in General Practice and Consultant Upgrade 2WW referral activity. METHODS: Data from 185 000 referrals and 29 000 cancers recorded between 2011 and 2013 from the Northern Ireland Cancer Waiting Time database (CaPPS) were analysed to ascertain standardised referral rate ratios, detection rate (DR) (=sensitivity) and conversion rate (CR) (=positive predictive value) for Practice 2WW referrals and Consultant Upgrade 2WW...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28736657/high-temporal-resolution-aberrometry-in-a-50-eye-population-and-implications-for-adaptive-optics-error-budget
#6
Jessica Jarosz, Pedro Mecê, Jean-Marc Conan, Cyril Petit, Michel Paques, Serge Meimon
We formed a database gathering the wavefront aberrations of 50 healthy eyes measured with an original custom-built Shack-Hartmann aberrometer at a temporal frequency of 236 Hz, with 22 lenslets across a 7-mm diameter pupil, for a duration of 20 s. With this database, we draw statistics on the spatial and temporal behavior of the dynamic aberrations of the eye. Dynamic aberrations were studied on a 5-mm diameter pupil and on a 3.4 s sequence between blinks. We noted that, on average, temporal wavefront variance exhibits a n(-2) power-law with radial order n and temporal spectra follow a f(-1...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28716481/-disseminated-nocardiosis-caused-by-nocardia-nova-with-brain-abscesses-and-osteomyelitis-in-an-immunocompetent-patient
#7
P-L Conan, C Ficko, F Charton, O Bylicki, H Le Floch, J Margery, F Rivière
INTRODUCTION: Nocardia is an opportunist bacteria involved in patients with cellular immunodepression or chronic lung disease. The most frequent portals of entry are the respiratory tract by inhalation or direct inoculation through a cutaneous effraction. Nocardiosis may be localised or disseminated. CASE REPORT: We report a rare case of disseminated nocardiosis to Nocardia nova with pulmonary, cutaneous, cerebral attacks and femoral osteomyelitis. The diagnosis was confirmed by prolonged cultures of the bronchoalveolar fluid and the pus extracted from a cutaneous lesion...
July 14, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28608120/cosmetic-outcome-and-chronic-breast-toxicity-after-intraoperative-radiation-therapy-iort-as-a-single-modality-or-as-a-boost-using-the-intrabeam-%C3%A2-device-a-prospective-study
#8
Stéphane Key, Petra Miglierini, Pierre-François Dupré, Sandrine Guilbert, Anne-Sophie Lucia, Ronan Abgral, Virginie Conan-Charlet, Arnaud Uguen, Olivier Pradier, Ulrike Schick
PURPOSE: We aim to report our results in terms of chronic toxicities and cosmetic outcomes after intraoperative radiotherapy (IORT) using kV X-rays in women treated for early breast cancer at our institution. METHODS: Patients with early breast carcinoma were recruited between April 2011 and November 2014. After breast-conserving surgery, patients were treated with IORT using the Intrabeam(®) device. IORT was completed by whole-breast radiotherapy (WBRT) at a dose of 46-50...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28602607/rabies-vaccine-is-associated-with-decreased-all-cause-mortality-in-dogs
#9
Darryn L Knobel, Sintayehu Arega, Bjorn Reininghaus, Gregory J G Simpson, Bradford D Gessner, Henrik Stryhn, Anne Conan
Evidence suggests that rabies vaccine may have non-specific protective effects in animals and children. We analyzed four years of data (2012-2015) from an observational study of the health and demographics of a population of owned, free-roaming dogs in a low-income community in South Africa. The objective of this analysis was to assess the association between rabies vaccine and all-cause mortality in dogs, stratified by age group (0-3months, 4-11months, and 12months and older), and controlling for the effects of sex and number of dogs in the residence...
July 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28600946/the-completeness-and-timeliness-of-cancer-registration-and-the-implications-for-measuring-cancer-burden
#10
Conan Donnelly, Victoria Cairnduff, Jingwen Jessica Chen, Therese Kearney, Deirdre Fitzpatrick, Colin Fox, Anna Gavin
BACKGROUND: Population based cancer registration provides a critical role in disease surveillance in terms of incidence, survival, cancer cluster investigations and prevalence trends, and therefore high levels of completeness and timeliness are required. This study estimates completeness and variation between early and late registrations in the N. Ireland Cancer Registry (NICR) and assesses the implications for reporting cancer incidence and for registry-based research. METHODS: Two main approaches assessed completeness...
June 7, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28580506/prolonged-overall-treatment-time-and-lack-of-skin-rash-negatively-impact-overall-survival-in-locally-advanced-head-and-neck-cancer-patients-treated-with-radiotherapy-and-concomitant-cetuximab
#11
Julien Roman, Gurvan Dissaux, Maelenn Gouillou, Yves Gobel, Gael Potard, Jean-Christophe Leclere, Virginie Conan-Charlet, Dorothy Gujral, Ronan Abgral, Briac Guibourg, Olivier Pradier, Ulrike Schick
BACKGROUND: Cetuximab, a chimeric monoclonal antibody against EGFR sensitizes tumors to radiotherapy (RT), but is associated with skin and mucosal toxicity. OBJECTIVE: We report outcomes and tolerance of definitive RT in association with cetuximab in patients with locally advanced squamous cell carcinoma (LASCC) of the head and neck. PATIENTS AND METHODS: Between 2006 and 2011, 92 consecutive patients with LASCC of the head and neck were treated with RT and concomitant weekly cetuximab...
August 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28542078/a-population-level-investigation-of-cancer-clinical-trials-participation-in-a-uk-region
#12
Conan B Donnelly, Amy C Wotherspoon, Melanie Morris, Richard H Wilson, Jingwen J Chen, Victoria Cairnduff, Eileen Morgan, Amy Devlin, Anna T Gavin
The aim of this study was to document cancer trial participation since establishment of the Northern Ireland Cancer Trials Network and investigate population and disease factors associated with trial participation. An independent cohort of over 51 000 cancer patients from the Northern Ireland Cancer Registry covering the same population (2007-2012) was linked to a database of 1316 interventional cancer trial participants in a UK region. The primary outcome measure was participation in an intervention clinical trial...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28480231/an-interprofessional-curriculum-on-antimicrobial-stewardship-improves-knowledge-and-attitudes-toward-appropriate-antimicrobial-use-and-collaboration
#13
Conan MacDougall, Brian S Schwartz, Lisa Kim, Mari Nanamori, Sharmin Shekarchian, Peter V Chin-Hong
BACKGROUND: Inappropriate antimicrobial use can threaten patient safety and is the focus of collaborative physician and pharmacist antimicrobial stewardship teams. However, antimicrobial stewardship is not comprehensively taught in medical or pharmacy school curricula. Addressing this deficiency can teach an important concept as well as model interprofessional healthcare. METHODS: We created an antimicrobial stewardship curriculum consisting of an online learning module and workshop session that combined medical and pharmacy students, with faculty from both professions...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28464069/phenotypic-and-haplotype-diversity-among-tetraploid-and-hexaploid-wheat-accessions-with-potentially-novel-insect-resistance-genes-for-wheat-stem-sawfly
#14
J P Cook, N K Blake, H Y Heo, J M Martin, D K Weaver, L E Talbert
Genetic diversity in breeding programs can be impaired by fixation of alleles derived from a limited number of founder lines. This is demonstrated with the use of a solid-stem trait derived from the Portuguese landrace 'S-615' over 70 yrs ago that is widely used to resist the wheat stem sawfly ( Norton, WSS) in North America. The objective of this study was to evaluate haplotype diversity underlying the quantitative trait locus (QTL) that controls the majority of the S-615 derived solid-stem genetic variation using single-nucleotide polymorphism (SNP) assays in a diverse set of 228 solid-stem tetraploid and hexaploid wheat accessions originating from areas of the world infested with various species of WSS...
March 2017: Plant Genome
https://www.readbyqxmd.com/read/28463547/economic-decision-model-for-first-time-traumatic-patellar-dislocations-in-adolescents
#15
Benedict U Nwachukwu, Conan So, William W Schairer, Beth E Shubin-Stein, Sabrina M Strickland, Daniel W Green, Emily R Dodwell
BACKGROUND: The surgical management of traumatic patellar dislocations in adolescents is associated with a lower rate of recurrent dislocations compared with nonoperative care. However, the attendant cost of surgery and the quality-of-life benefit of a surgical treatment strategy are unclear. PURPOSE: To compare the cost-utility of 3 management strategies for acute first-time patellar dislocations in adolescents: (1) nonoperative treatment only, (2) initial nonoperative treatment with surgery only for recurrent dislocations, and (3) immediate surgery...
August 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28459137/lysine-to-arginine-mutagenesis-of-chlorotoxin-enhances-its-cellular-uptake
#16
Paola G Ojeda, Sónia Troeira Henriques, Yijun Pan, Joseph A Nicolazzo, David J Craik, Conan K Wang
Chlorotoxin (CTX), a disulfide-rich peptide from the scorpion Leiurus quinquestriatus, has several promising biopharmaceutical properties, including preferential affinity for certain cancer cells, high serum stability, and cell penetration. These properties underpin its potential for use as a drug design scaffold, especially for the treatment of cancer; indeed, several analogs of CTX have reached clinical trials. Here, we focus on its ability to internalize into cells-a trait associated with a privileged subclass of peptides called cell-penetrating peptides-and whether it can be improved through conservative substitutions...
September 2017: Biopolymers
https://www.readbyqxmd.com/read/28407132/causal-mechanism-and-component-causes-in-mesoamerican-sri-lankan-nephropathy-the-moderator-s-view
#17
Carmine Zoccali
Inspired by Conan Doyle's novels, the pro contender of this Polar View undertakes an elegant exercise in territory common to epidemiology and police investigation and concludes that cyclic episodes of dehydration in individuals exposed to heavy work in very hot climates is the cause of Mesoamerican and Sri Lankan nephropathy. The contender in the opposite camp accepts the idea that dehydration may play a key role in this condition but highlights a different explanation, that it is contaminated water used for rehydration that is the eventual cause of the disease...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28381885/a-novel-teaching-tool-combined-with-active-learning-to-teach-antimicrobial-spectrum-activity
#18
Conan MacDougall
Objective. To design instructional methods that would promote long-term retention of knowledge of antimicrobial pharmacology, particularly the spectrum of activity for antimicrobial agents, in pharmacy students. Design. An active-learning approach was used to teach selected sessions in a required antimicrobial pharmacology course. Students were expected to review key concepts from the course reader prior to the in-class sessions. During class, brief concept reviews were followed by active-learning exercises, including a novel schematic method for learning antimicrobial spectrum of activity ("flower diagrams")...
March 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28377220/estimating-occurrence-of-strongyloides-stercoralis-in-the-caribbean-island-countries-implications-for-monitoring-and-control
#19
Jennifer K Ketzis, Anne Conan
BACKGROUND: Few data are available for the prevalence of Strongyloides stercoralis in the Caribbean region. This frequently under diagnosed soil-transmitted helminth (STH) can result in long-term low intensity chronic infections that are asymptomatic or can cause varied intestinal disturbances. With autoinfections, infections lasting over 60 years can occur and hyperinfections lead to high morbidity and mortality. METHODOLOGY/PRINCIPAL FINDINGS: Historical literature was searched to determine the prevalence of S...
April 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28375373/pupil-motion-analysis-and-tracking-in-ophthalmic-systems-equipped-with-wavefront-sensing-technology
#20
Serge Meimon, Jessica Jarosz, Cyril Petit, Elena Gofas Salas, Kate Grieve, Jean-Marc Conan, Bruno Emica, Michel Paques, Kristina Irsch
Our eyes are constantly in motion, even during "steady" fixation. In ophthalmic systems equipped with wavefront technology, both eye and head motion potentially degrade its performance and/or increase the cost and complexity, as they induce a movement of the entrance optical pupil of the system. Here, we characterize the pupil motion in an aberrometry setting, using a custom, high-speed pupil tracker (478 Hz), and draw conclusions on design considerations of future ophthalmic systems. We also demonstrate the feasibility of tracking such motion directly with a custom-built Hartmann-Shack sensor (236 Hz) using a method that offers certain benefits over previously suggested approaches, thereby paving the way to an efficient and cost-effective approach...
March 20, 2017: Applied Optics
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