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https://www.readbyqxmd.com/read/27927667/life-after-prostate-cancer-diagnosis-protocol-for-a-uk-wide-patient-reported-outcomes-study
#1
Amy Downing, Penny Wright, Richard Wagland, Eila Watson, Therese Kearney, Rebecca Mottram, Majorie Allen, Victoria Cairnduff, Oonagh McSorley, Hugh Butcher, Luke Hounsome, Conan Donnelly, Peter Selby, Paul Kind, William Cross, James W H Catto, Dyfed Huws, David H Brewster, Emma McNair, Lauren Matheson, Carol Rivas, Johana Nayoan, Mike Horton, Jessica Corner, Julia Verne, Anna Gavin, Adam W Glaser
BACKGROUND: Prostate cancer and its treatment may impact physically, psychologically and socially; affecting the health-related quality of life of men and their partners/spouses. The Life After Prostate Cancer Diagnosis (LAPCD) study is a UK-wide patient-reported outcomes study which will generate information to improve the health and well-being of men with prostate cancer. METHODS AND ANALYSIS: Postal surveys will be sent to prostate cancer survivors (18-42 months postdiagnosis) in all 4 UK countries (n=∼70 000)...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27908045/source-depth-discrimination-with-a-vertical-line-array
#2
Ewen Conan, Julien Bonnel, Thierry Chonavel, Barbara Nicolas
Source depth estimation with a vertical line array generally involves mode filtering, then matched-mode processing. Because mode filtering is an ill-posed problem if the water column is not well-sampled, concerns for robustness motivate a simpler approach: source depth discrimination considered as a binary classification problem. It aims to evaluate whether the source is near the surface or submerged. These two hypotheses are formulated in terms of normal modes, using the concept of trapped and free modes. Decision metrics based on classic mode filters are proposed...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27878993/forward-for-iccp2015-issue-of-biopolymers-peptide-science
#3
EDITORIAL
David J Craik, Conan K Wang
No abstract text is available yet for this article.
November 2016: Biopolymers
https://www.readbyqxmd.com/read/27871755/multicontamination-phenomena-occur-more-often-than-expected-in-mediterranean-coastal-watercourses-study-case-of-the-t%C3%A3%C2%AAt-river-france
#4
Brice Reoyo-Prats, Dominique Aubert, Christophe Menniti, Wolfgang Ludwig, Jennifer Sola, Mireille Pujo-Pay, Pascal Conan, Olivier Verneau, Carmen Palacios
Contaminants found in watercourses are not only the result of anthropogenic activities but also depend on river's seasonal hydrodynamics. This is particularly true in Mediterranean climate regions where long dry periods are interrupted by strong rainfalls. Storm events remobilize particles from soils and sediments and, as a consequence, the load of particulate matter in rivers can be quite considerable, severely affecting water quality. Nevertheless, an absence of fieldwork studies exists concerning the simultaneous dynamics of mixtures of pollutants in river waters, particularly during strong rainfalls and floods...
November 18, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27707856/the-early-impact-of-an-administrative-processing-fee-on-manuscript-submissions-at-the-journal-of-bone-joint-surgery
#5
Benedict U Nwachukwu, William W Schairer, Conan So, Jaime L Bernstein, James Herndon, Emily R Dodwell
BACKGROUND: There was a dramatic increase in the volume of manuscripts submitted to The Journal of Bone & Joint Surgery (JBJS) between 2009 and 2012. This resulted in increased journal administrative costs. To offset this financial burden, in May 2013, JBJS started charging authors an administrative processing fee at the time of submission. The purpose of this study was to assess the impact of the administrative fee on the volume and characteristics of manuscripts submitted to JBJS. METHODS: Our analysis included 866 manuscripts submitted to JBJS between November 2012 and November 2013...
October 5, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27685156/generation-of-two-color-antigen-microarrays-for-the-simultaneous-detection-of-igg-and-igm-autoantibodies
#6
Andrzej Chruscinski, Flora Y Y Huang, Antigona Ulndreaj, Conan Chua, Michael Fehlings, Vivek Rao, Heather J Ross, Gary A Levy
Autoantibodies, which are antibodies against self-antigens, are present in many disease states and can serve as markers for disease activity. The levels of autoantibodies to specific antigens are typically detected with the enzyme-linked immunosorbent assay (ELISA) technique. However, screening for multiple autoantibodies with ELISA can be time-consuming and requires a large quantity of patient sample. The antigen microarray technique is an alternative method that can be used to screen for autoantibodies in a multiplex fashion...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27663486/the-use-of-pain-relief-during-labor-among-migrant-obstetric-populations
#7
Viera Husarova, Laura Macdarby, Patrick Dicker, Fergal D Malone, Conan L McCaul
OBJECTIVE: To identify patterns in intrapartum analgesia use in the migrant obstetric population. METHODS: A retrospective analysis included all deliveries with neonates above 500g in weight at a university hospital in Dublin, Ireland between 2009 and 2013. Analgesia was classified as neuraxial or non-neuraxial. Parturients were excluded owing to missing data, elective cesarean deliveries, and the use of analgesia during treatment for obstetric complications. RESULTS: There were 36 689 deliveries included in the present study...
November 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27636014/controlled-growth-of-nanostructured-biotemplates-with-cobalt-and-nitrogen-codoping-as-a-binderless-lithium-ion-battery-anode
#8
Tyler M Huggins, Justin M Whiteley, Corey T Love, Kwangwon Lee, Se-Hee Lee, Zhiyong Jason Ren, Justin C Biffinger
Biomass can serve as a sustainable template for the synthesis of carbon materials but is limited by the intrinsic properties of the precursor organism. In this study we demonstrate that the properties of a fungal biotemplate can be tuned during cultivation, establishing a new electrode manufacturing process and ultimately improving the electrochemical performance of the biomass-derived electrode. More specifically, the carbon/nitrogen ratio of Neurospora crassa mycelia mats was shifted by 5-fold while generating cobalt nanoparticles into the hyphal structure originating from macroconidia spores...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27615364/design-and-demonstration-of-an-intracortical-probe-technology-with-tunable-modulus
#9
Dustin M Simon, Hamid Charkhkar, Conan St John, Sakthi Rajendran, Tong Kang, Radu Reit, David Arreaga-Salas, Daniel G McHail, Gretchen L Knaack, Andrew Sloan, Dane Grasse, Theodore C Dumas, Robert L Rennaker, Joseph J Pancrazio, Walter E Voit
Intracortical probe technology, consisting of arrays of microelectrodes, offers a means of recording the bioelectrical activity from neural tissue. A major limitation of existing intracortical probe technology pertains to limited lifetime of 6 months to a year of recording after implantation. A major contributor to device failure is widely believed to be the interfacial mechanical mismatch of conventional stiff intracortical devices and the surrounding brain tissue. We describe the design, development, and demonstration of a novel functional intracortical probe technology that has a tunable Young's modulus from ∼2 GPa to ∼50 MPa...
January 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27376644/a-1842-skull-from-dupuytren-s-museum-of-paris-an-original-artifact-of-joseph-gensoul-first-maxillectomy-technique
#10
Nadia Benmoussa, Jennifer Kerner, Patrice Josset, Patrick Conan, Philippe Charlier
Joseph Gensoul was a pioneer of ENT surgery. In 1827, he performed the first total maxillectomy on 17-year-old boy. His work inspired many surgeons, who were previously unwilling to remove maxillary tumours. A paleopathological study performed in the Dupuytren museum allowed us to identify a skull from the early 19th century, with a large maxillar tumour. There were indications that this skull was operated according to Gensoul's technique. The aim of this study is to confirm that this patient had, in fact, received this surgical treatment...
July 4, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27250168/estimation-of-saxophone-reed-parameters-during-playing
#11
Alberto Muñoz Arancón, Bruno Gazengel, Jean-Pierre Dalmont, Ewen Conan
An approach for the estimation of single reed parameters during playing, using an instrumented mouthpiece and an iterative method, is presented. Different physical models describing the reed tip movement are tested in the estimation method. The uncertainties of the sensors installed on the mouthpiece and the limits of the estimation method are studied. A tenor saxophone reed is mounted on this mouthpiece connected to a cylinder, played by a musician, and characterized at different dynamic levels. Results show that the method can be used to estimate the reed parameters with a small error for low and medium sound levels (piano and mezzoforte dynamic levels)...
May 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27199618/beyond-susceptible-and-resistant-part-iii-treatment-of-infections-due-to-gram-negative-organisms-producing-carbapenemases
#12
REVIEW
Navaneeth Narayanan, Linda Johnson, Conan MacDougall
Carbapenemases are enzymes that are capable of inactivating all or almost all beta-lactam antimicrobial agents. These enzymes are frequently coexpressed with other resistance mechanisms to non-beta-lactams, leading to extremely drug-resistant pathogens. Once a curiosity, these enzymes have spread into organisms that are among the most common causes of infection, such as Klebsiella pneumoniae and Escherichia coli. Identification of these organisms has proved challenging for clinical microbiology laboratories, leading to revisions in susceptibility standards for carbapenems...
March 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27178381/cyclic-peptide-oral-bioavailability-lessons-from-the-past
#13
Conan K Wang, David J Craik
Achieving high oral bioavailability for drugs is a key design objective in drug development. It is not surprising then that with the growing expectation of peptides as future drugs, there has also been an increasing interest in developing oral peptide therapeutics. Brought to the fore are questions such as what makes peptides orally bioavailable and how this can be achieved; questions which have inspired research into the area for decades. Early research in the area focused on linear peptides with more recent literature focusing on cyclic peptides, motivated in part by cyclic peptides like cyclosporine A that have demonstrated drug-like oral bioavailability...
May 14, 2016: Biopolymers
https://www.readbyqxmd.com/read/27170617/bereavement-outcomes-a-quantitative-survey-identifying-risk-factors-in-informal-carers-bereaved-through-cancer
#14
Audrey Roulston, Anne Campbell, Victoria Cairnduff, Deirdre Fitzpatrick, Conan Donnelly, Anna Gavin
BACKGROUND: Enabling patients to die in their preferred place is important but achieving preferred place of death may increase the informal carer's risk into bereavement. AIM: To determine risk factors of family carers bereaved through cancer in Northern Ireland. DESIGN: These results form part of a larger QUALYCARE-NI study which used postal questionnaires to capture quantitative data on carer's bereavement scores using the Texas Revised Inventory of Grief...
May 11, 2016: Palliative Medicine
https://www.readbyqxmd.com/read/27126490/near-real-time-monitoring-of-hiv-transmission-hotspots-from-routine-hiv-genotyping-an-implementation-case-study
#15
Art F Y Poon, Réka Gustafson, Patricia Daly, Laura Zerr, S Ellen Demlow, Jason Wong, Conan K Woods, Robert S Hogg, Mel Krajden, David Moore, Perry Kendall, Julio S G Montaner, P Richard Harrigan
BACKGROUND: HIV evolves rapidly and therefore infections with similar genetic sequences are likely linked by recent transmission events. Clusters of related infections can represent subpopulations with high rates of transmission. We describe the implementation of an automated near real-time system to monitor and characterise HIV transmission hotspots in British Columbia, Canada. METHODS: In this implementation case study, we applied a monitoring system to the British Columbia drug treatment database, which holds more than 32 000 anonymised HIV genotypes for nearly 9000 residents of British Columbia living with HIV...
May 2016: Lancet HIV
https://www.readbyqxmd.com/read/27118828/executive-summary-implementing-an-antibiotic-stewardship-program-guidelines-by-the-infectious-diseases-society-of-america-and-the-society-for-healthcare-epidemiology-of-america
#16
Tamar F Barlam, Sara E Cosgrove, Lilian M Abbo, Conan MacDougall, Audrey N Schuetz, Edward J Septimus, Arjun Srinivasan, Timothy H Dellit, Yngve T Falck-Ytter, Neil O Fishman, Cindy W Hamilton, Timothy C Jenkins, Pamela A Lipsett, Preeti N Malani, Larissa S May, Gregory J Moran, Melinda M Neuhauser, Jason G Newland, Christopher A Ohl, Matthew H Samore, Susan K Seo, Kavita K Trivedi
Evidence-based guidelines for implementation and measurement of antibiotic stewardship interventions in inpatient populations including long-term care were prepared by a multidisciplinary expert panel of the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. The panel included clinicians and investigators representing internal medicine, emergency medicine, microbiology, critical care, surgery, epidemiology, pharmacy, and adult and pediatric infectious diseases specialties...
May 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27093300/efficient-enzymatic-cyclization-of-an-inhibitory-cystine-knot-containing-peptide
#17
Soohyun Kwon, Frank Bosmans, Quentin Kaas, Olivier Cheneval, Anne C Conibear, K Johan Rosengren, Conan K Wang, Christina I Schroeder, David J Craik
Disulfide-rich peptides isolated from cone snails are of great interest as drug leads due to their high specificity and potency toward therapeutically relevant ion channels and receptors. They commonly contain the inhibitor cystine knot (ICK) motif comprising three disulfide bonds forming a knotted core. Here we report the successful enzymatic backbone cyclization of an ICK-containing peptide κ-PVIIA, a 27-amino acid conopeptide from Conus purpurascens, using a mutated version of the bacterial transpeptidase, sortase A...
October 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27080992/implementing-an-antibiotic-stewardship-program-guidelines-by-the-infectious-diseases-society-of-america-and-the-society-for-healthcare-epidemiology-of-america
#18
Tamar F Barlam, Sara E Cosgrove, Lilian M Abbo, Conan MacDougall, Audrey N Schuetz, Edward J Septimus, Arjun Srinivasan, Timothy H Dellit, Yngve T Falck-Ytter, Neil O Fishman, Cindy W Hamilton, Timothy C Jenkins, Pamela A Lipsett, Preeti N Malani, Larissa S May, Gregory J Moran, Melinda M Neuhauser, Jason G Newland, Christopher A Ohl, Matthew H Samore, Susan K Seo, Kavita K Trivedi
Evidence-based guidelines for implementation and measurement of antibiotic stewardship interventions in inpatient populations including long-term care were prepared by a multidisciplinary expert panel of the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. The panel included clinicians and investigators representing internal medicine, emergency medicine, microbiology, critical care, surgery, epidemiology, pharmacy, and adult and pediatric infectious diseases specialties...
May 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27064294/mirror-images-of-antimicrobial-peptides-provide-reflections-on-their-functions-and-amyloidogenic-properties
#19
Conan K Wang, Gordon J King, Anne C Conibear, Mariana C Ramos, Stephanie Chaousis, Sónia Troeira Henriques, David J Craik
Enantiomeric forms of BTD-2, PG-1, and PM-1 were synthesized to delineate the structure and function of these β-sheet antimicrobial peptides. Activity and lipid-binding assays confirm that these peptides act via a receptor-independent mechanism involving membrane interaction. The racemic crystal structure of BTD-2 solved at 1.45 Å revealed a novel oligomeric form of β-sheet antimicrobial peptides within the unit cell: an antiparallel trimer, which we suggest might be related to its membrane-active form. The BTD-2 oligomer extends into a larger supramolecular state that spans the crystal lattice, featuring a steric-zipper motif that is common in structures of amyloid-forming peptides...
May 4, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27059603/impact-of-an-intense-water-column-mixing-0-1500m-on-prokaryotic-diversity-and-activities-during-an-open-ocean-convection-event-in-the-nw-mediterranean-sea
#20
T Severin, C Sauret, M Boutrif, T Duhaut, F Kessouri, L Oriol, J Caparros, M Pujo-Pay, X Durrieu de Madron, M Garel, C Tamburini, P Conan, J F Ghiglione
Open-ocean convection is a fundamental process for thermohaline circulation and biogeochemical cycles that causes spectacular mixing of the water column. Here, we tested how much the depth-stratified prokaryotic communities were influenced by such an event, and also by the following re-stratification. The deep convection event (0-1500m) that occurred in winter 2010-2011 in the NW Mediterranean Sea resulted in a homogenization of the prokaryotic communities over the entire convective cell, resulting in the predominance of typical surface Bacteria, such as Oceanospirillale and Flavobacteriales...
April 5, 2016: Environmental Microbiology
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