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https://www.readbyqxmd.com/read/28930719/vascular-access-placement-order-and-outcomes-in-hemodialysis-patients-a-longitudinal-study
#1
Mariana Murea, W Mark Brown, Jasmin Divers, Shahriar Moossavi, Todd W Robinson, Benjamin Bagwell, John M Burkart, Barry I Freedman
BACKGROUND: Arteriovenous accesses (AVA) in patients performing hemodialysis (HD) are labeled "permanent" for AV fistulas (AVF) or grafts (AVG) and "temporary" for tunneled central venous catheters (TCVC). Durability and outcomes of permanent vascular accesses based on the sequence in which they were placed or used receives little attention. This study analyzed longitudinal transitions between TCVC-based and AVA-based HD outcomes according to the order of placement. METHODS: All 391 patients initiating chronic HD via a TCVC between 2012 and 2013 at 12 outpatient academic dialysis units were included in this study...
September 21, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28922502/the-three-component-system-esrisr-regulates-a-cell-envelope-stress-response-in-corynebacterium-glutamicum
#2
Britta Kleine, Ava Chattopadhyay, Tino Polen, Daniela Pinto, Thorsten Mascher, Michael Bott, Melanie Brocker, Roland Freudl
When the cell envelope integrity is compromised, bacteria trigger signaling cascades resulting in the production of proteins that counteract these extracytoplasmic stresses. Here, we show that the two-component system EsrSR regulates a cell envelope stress response in the Actinobacterium Corynebacterium glutamicum. The sensor kinase EsrS possesses an amino-terminal phage shock protein C (PspC) domain, a property that sets EsrSR apart from all other two-component systems characterized so far. An integral membrane protein, EsrI, whose gene is divergently transcribed to the esrSR gene locus and which interestingly also possesses a PspC domain, acts as an inhibitor of EsrSR under non-stress conditions...
September 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28922302/resident-knowledge-surgical-skill-and-confidence-in-transobturator-vaginal-tape-placement-the-value-of-a-cadaver-laboratory
#3
Woojin Chong, Keith Downing, Ava Leegant, Erika Banks, Dmitry Fridman, Sherry Downie
OBJECTIVES: The objective of this study is to examine the effect of additional cadaver laboratory use in training obstetrics and gynecology (OBGYN) residents on transobturator vaginal tape (TOT) insertion. METHODS: Thirty-four OBGYN residents were randomized into 2 groups (group 1, control; group 2, intervention; 17 in each group). Before and after the interventions, written knowledge and confidence levels were assessed. Both groups received didactic lectures using a bony pelvis and an instructional video on TOT insertion; group 2 participated in a half day cadaver laboratory...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28916245/tetanus-diphtheria-and-acellular-pertussis-vaccination-during-pregnancy-and-reduced-risk-of-infant-acute-respiratory-infections
#4
Zeina G Khodr, Anna T Bukowinski, Gia R Gumbs, Ava Marie S Conlin
BACKGROUND: To protect infants from pertussis infection, the Advisory Committee on Immunization Practices (ACIP) recommends women receive the tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccine between 27 and 36weeks of pregnancy. Here, we assessed the association between timing of maternal Tdap vaccination during pregnancy and acute respiratory infection (ARI) in infants <2months of age. METHODS: This retrospective cohort study included 99,434 infants born to active duty military women in the Department of Defense Birth and Infant Health Registry from 2006 through 2013...
September 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28910168/reduced-central-retinal-artery-blood-flow-is-related-to-impaired-central-visual-function-in-retinitis-pigmentosa-patients
#5
Samantha Kayser, Patricia Vargas, Deborah Mendelsohn, Jorge Han, Hua Bi, Alexandra Benavente, Ava K Bittner
PURPOSE: We evaluated the test-retest repeatability of blood flow velocities in the retrobulbar central retinal artery (CRA) and explored whether reduced blood flow is related to the degree of visual function loss in retinitis pigmentosa (RP) patients with wide range of disease severity. MATERIALS AND METHODS: We measured CRA peak systolic velocity (PSV) and end diastolic velocity (EDV) to calculate mean flow velocity (MFV) in 18 RP patients using color Doppler imaging with spectral flow Doppler (GE Logiq7 ultrasound) twice in each eye at each of two visits within a month...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28910132/modified-african-ngoma-healing-ceremony-for-stress-reduction-a-pilot-study
#6
Ava LaVonne Vinesett, Riitta Rutanen Whaley, Cheryl Woods-Giscombe, Paul Dennis, Medina Johnson, Yin Li, Pline Mounzeo, Mabiba Baegne, Kenneth H Wilson
OBJECTIVE: Indigenous people's ceremonies using rhythm and dance have been used for countless generations throughout the world for healing, conflict resolution, social bonding, and spiritual experience. A previous study reported that a ceremony based on the Central African ngoma tradition was favorably received by a group of Americans. The present trial compared the effects of the modified ngoma ceremony (Ngoma) with those of mindfulness-based stress reduction (MBSR) in a randomized pilot study...
September 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28899392/care-beyond-the-hospital-ward-understanding-the-socio-medical-trajectory-of-herpes-simplex-virus-encephalitis
#7
Jessie Cooper, Ciara Kierans, Sylviane Defres, Ava Easton, Rachel Kneen, Tom Solomon
BACKGROUND: Herpes simplex virus (HSV) encephalitis is a life-threatening infection of the brain, which has significant physical, cognitive and social consequences for survivors. Despite increasing recognition of the long-term effects of encephalitis, research and policy remains largely focused on its acute management, meaning there is little understanding of the difficulties people face after discharge from acute care. This paper aims to chart the problems and challenges which people encounter when they return home after treatment for HSV encephalitis...
September 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28890466/changes-in-aortic-pulse-wave-velocity-and-the-predictors-of-improvement-in-arterial-stiffness-following-aortic-valve-replacement
#8
Emir Cantürk, Beytullah Çakal, Oğuz Karaca, Onur Omaygenç, Salih Salihi, Arda Özyüksel, Atıf Akçevin
BACKGROUND: The interaction between valvular aortic stenosis (AS) and arterial stiffness, as well as the impact of aortic valve replacement (AVR) on arterial stiffness, remains unclear. In this study, we aimed to evaluate the degree of AS severity on non-invasive pulse wave velocity (PWV) measurements. We also searched whether the AVR procedure favorably affects PWV. METHODS: In all, 38 patients undergoing AVR for chronic AS were included. The degree of aortic stiffness was measured with PWV at both baseline and 6 months after AVR...
September 8, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28889763/identification-of-methylated-metabolites-of-oat-avenanthramides-in-human-plasma-using-uhplc-qtof-ms
#9
Jason Walsh, Jordan Haddock, Jeffrey B Blumberg, Diane L McKay, Xiaoyong Wei, Gregory Dolnikowski, C-Y Oliver Chen
Oat avenanthramides (AVAs) are a group of phenolic alkaloids, consisting of an anthranilic acid and a hydroxycinnamic acid linked by a pseudo-peptide bond. Bioavailability of AVA is poor in humans, suggesting transformations for rapid excretion. Thus, we aim to identify metabolites of AVA isomers in plasma of humans after consuming AVA-enriched oats. After lipid removal, AVA and their metabolites in plasma were extracted with ethyl acetate and analysed using an Agilent UHPLC-QToF-MS. Pharmacokinetics of AVA-O showed a bimodal distribution with Cmax1 and 2 for AVA-O at 5...
September 11, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28877928/anthrax-vaccine-precipitated-induces-edema-toxin-neutralizing-edema-factor-specific-antibodies-in-human-recipients
#10
Eric K Dumas, Timothy Gross, Jason Larabee, Lance Pate, Hannah Cuthbertson, Sue Charlton, Bassam Hallis, Renata J M Engler, Limone C Collins, Christina E Spooner, Hua Chen, Jimmy Ballard, Judith A James, A Darise Farris
Edema Toxin (ET), composed of Edema Factor (EF) and Protective Antigen (PA), is a virulence factor of Bacillus anthracis that alters host immune cell function and contributes to anthrax disease. Anthrax Vaccine Precipitated (AVP) contains low but detectable EF and can elicit EF-specific antibodies in human recipients of AVP. Active and passive vaccination of mice with EF can contribute to protection from challenge with Bacillus anthracis spores or ET. This study compared humoral responses to ET in recipients of AVP (n=33) versus Anthrax Vaccine Adsorbed (AVA; n=66) matched for number of vaccinations and time post-vaccination and furthermore determined whether EF antibodies elicited by AVP contribute to ET neutralization...
September 6, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28874462/%C3%AE-arrestin2-improves-post-myocardial-infarction-heart-failure-via-sarco-endo-plasmic-reticulum-ca-2-atpase-dependent-positive-inotropy-in-cardiomyocytes
#11
Katie A McCrink, Jennifer Maning, Angela Vu, Malika Jafferjee, Christine Marrero, Ava Brill, Ashley Bathgate-Siryk, Samalia Dabul, Walter J Koch, Anastasios Lymperopoulos
Heart failure is the leading cause of death in the Western world, and new and innovative treatments are needed. The GPCR (G protein-coupled receptor) adapter proteins βarr (β-arrestin)-1 and βarr-2 are functionally distinct in the heart. βarr1 is cardiotoxic, decreasing contractility by opposing β1AR (adrenergic receptor) signaling and promoting apoptosis/inflammation post-myocardial infarction (MI). Conversely, βarr2 inhibits apoptosis/inflammation post-MI but its effects on cardiac function are not well understood...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28869812/the-effects-of-prosthetic-foot-stiffness-on-transtibial-amputee-walking-mechanics-and-balance-control-during-turning
#12
Courtney E Shell, Ava D Segal, Glenn K Klute, Richard R Neptune
BACKGROUND: Little evidence exists regarding how prosthesis design characteristics affect performance in tasks that challenge mediolateral balance such as turning. This study assesses the influence of prosthetic foot stiffness on amputee walking mechanics and balance control during a continuous turning task. METHODS: Three-dimensional kinematic and kinetic data were collected from eight unilateral transtibial amputees as they walked overground at self-selected speed clockwise and counterclockwise around a 1-meter circle and along a straight line...
August 15, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28868296/hemodialysis-arteriovenous-access-occlusion-using-the-amplatzer-vascular-plug-in-patients-with-intractable-arm-edema
#13
Michele Di Filippo, Danilo Barbarisi, Doriana Ferrara, Stefania Brancaccio, Luca Del Guercio, Renata Bracale, Alfredo Capuano, Giovanni Esposito, Umberto Marcello Bracale
OBJECTIVES: Vascular occlusion of hemodialysis arteriovenous access (AVA) using an Amplatzer vascular plug (AVP; St. Jude Medical, St. Paul, MN, USA) is an arising and alternative practice in selected patients; however, few reported cases can be found in the literature. Herein, we report on our experience with endovascular treatment of complicated AVA. MATERIALS AND METHODS: From September 2015 to December 2016, 3 patients at our clinic underwent an occlusion of hemodialysis AVA with 2 different Amplatzer vascular plugs: 2 patients with type II and 1 patient with type IV...
May 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28864136/severe-aortic-stenosis-patients-with-preserved-ejection-fraction-according-to-flow-and-gradient-classification-prevalence-and-outcomes
#14
Ariana González Gómez, Covadonga Fernández-Golfín, Juan Manuel Monteagudo, Carlos Izurieta, Rocío Hinojar, Ana García, Eduardo Casas, José Julio Jiménez-Nacher, José Luis Moya, Soledad Ruiz, José Luis Zamorano
BACKGROUND: Clinicians often encounter patients with apparently discordant echocardiographic findings, severe aortic stenosis (SAS) defined by aortic valve area (AVA) despite a low mean gradient. A new classification according to flow state and pressure gradient has been proposed. We sought to assess the prevalence, characteristics and outcomes of patients with asymptomatic SAS with preserved left-ventricular ejection fraction (LVEF) according to flow and gradient. METHODS AND RESULTS: In total 442 patients with SAS (AVAi<0...
August 29, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28863237/a-prospective-analysis-evaluating-tissue-biopsy-location-and-its-clinical-relevance-in-chronic-rhinosinusitis-with-nasal-polyps
#15
Ava R Weibman, Julia He Huang, Whitney W Stevens, Lydia A Suh, Caroline P E Price, Alcina K Lidder, David B Conley, Kevin C Welch, Stephanie Shintani-Smith, Anju T Peters, Leslie C Grammer, Atsushi Kato, Robert C Kern, Robert P Schleimer, Bruce K Tan
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high propensity for recurrence. Studies suggest that eosinophilia influences disease severity and surgical outcomes, but the selection of sinonasal site for measuring eosinophilia has not been examined. The aim of this study was to investigate how region-specific tissue eosinophilia affects radiographic severity, comorbidity prevalence, and polyp recurrence risk following sinus surgery. METHODS: Eosinophil cationic protein (ECP) levels in uncinate tissue (UT) and nasal polyp (NP) homogenates from 116 CRSwNP patients were measured using enzyme-linked immunosorbent assay (ELISA)...
September 1, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28855350/macrophages-facilitate-resistance-to-anti-vegf-therapy-by-altered-vegfr-expression
#16
Anil K Sood, Heather J Dalton, Sunila Pradeep, Michael McGuire, Yared Hailemichael, Shaolin Ma, Yasmin Lyons, Guillermo N Armaiz-Pena, Rebecca A Previs, Jean M Hansen, Rajesha Rupaimoole, Vianey Gonzalez-Villasana, Min Soon Cho, Sherry Wu, Lingegowda S Mangala, Nicholas B Jennings, Wei Hu, Robert R Langley, Hong Mu, Michael Andreeff, Menashe Bar-Eli, Willem W Overwijk, Prahlad T Ram, Gabriel Lopez-Berestein, Robert L Coleman
PURPOSE: VEGF-targeted therapies have modest efficacy in cancer patients, but acquired resistance is common. The mechanisms underlying such resistance are poorly understood. EXPERIMENTAL DESIGN: To evaluate the potential role of immune cells in the development of resistance to VEGF blockade, we first established a preclinical model of adaptive resistance to anti-VEGF therapy. Additional in vitro and in vivo studies were carried out to characterize the role of macrophages in such resistance...
August 29, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28846524/outcome-of-patients-with-low-flow-low-gradient-severe-aortic-stenosis-who-underwent-aortic-valve-replacement
#17
Xing Li Fan, Jiajun Zhang, Chong Wang, Hongmei Chong, Guanxin Zhang, Qing Xue, Yangfeng Tang, Lin Han
It is well-documented that stroke volume and gradient are indexed to classify patients with aortic stenosis into several phenotypes. The purpose of the present study was to estimate the impact of stroke volume and gradient on the clinical outcome of patients with AS who have undergone aortic valve replacement. Methods: A total of 154 consecutive patients were studied. They all had severe aortic stenosis (aortic valve area [AVA] ≤ 1 cm², left ventricular ejection fraction [LVEF] ≥ 50%) and underwent aortic valve replacement (AVR) from January 1, 2004 to December 31, 2010...
July 20, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28846090/an-improved-atac-seq-protocol-reduces-background-and-enables-interrogation-of-frozen-tissues
#18
M Ryan Corces, Alexandro E Trevino, Emily G Hamilton, Peyton G Greenside, Nicholas A Sinnott-Armstrong, Sam Vesuna, Ansuman T Satpathy, Adam J Rubin, Kathleen S Montine, Beijing Wu, Arwa Kathiria, Seung Woo Cho, Maxwell R Mumbach, Ava C Carter, Maya Kasowski, Lisa A Orloff, Viviana I Risca, Anshul Kundaje, Paul A Khavari, Thomas J Montine, William J Greenleaf, Howard Y Chang
We present Omni-ATAC, an improved ATAC-seq protocol for chromatin accessibility profiling that works across multiple applications with substantial improvement of signal-to-background ratio and information content. The Omni-ATAC protocol generates chromatin accessibility profiles from archival frozen tissue samples and 50-μm sections, revealing the activities of disease-associated DNA elements in distinct human brain structures. The Omni-ATAC protocol enables the interrogation of personal regulomes in tissue context and translational studies...
August 28, 2017: Nature Methods
https://www.readbyqxmd.com/read/28836891/ava-christmas-meeting-queen-mary-university-of-london-december-19-2016
#19
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28834761/novel-pan-pi3k-inhibitor-induced-apoptosis-in-apl-cells-correlates-with-suppression-of-telomerase-an-emerging-mechanism-of-action-of-bkm120
#20
Davood Bashash, Mahda Delshad, Ava Safaroghli-Azar, Majid Safa, Majid Momeny, Seyed H Ghaffari
The intertwining between cancer pathogenesis and perturbation of multitude signaling pathways ushered the cancer therapeutic approaches into an unbounded route of targeted therapies. For the nonce and among the plethora of promising inhibitors, intense interest has focused on small molecules targeting different component of PI3K axis. Intrigued by the constant activation of PI3K in leukemia, this study aimed to investigate the effects of BKM120, as the excelled member of pan PI3K inhibitors, in a panel of hematologic malignant cell lines...
August 20, 2017: International Journal of Biochemistry & Cell Biology
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