Nicholas J Steers, Yask Gupta, Vivette D D'Agati, Tze Y Lim, Natalia DeMaria, Anna Mo, Judy Liang, Kelsey O Stevens, Dina F Ahram, Wan Yee Lam, Mihai Gagea, Lalitha Nagarajan, Simone Sanna-Cherchi, Ali G Gharavi
BACKGROUND: To gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN). METHODS: We first generated F1 hybrids between HIV-1 transgenic mice on the FVB/NJ background and 20 inbred laboratory strains. Analysis of histology, BUN, and urinary NGAL demonstrated marked phenotypic variation among the transgenic F1 hybrids, providing strong evidence for host genetic factors in the predisposition to nephropathy...
January 2022: Journal of the American Society of Nephrology: JASN