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Biglycan

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https://www.readbyqxmd.com/read/27925300/the-importance-of-serum-biglycan-levels-as-a-fibrosis-marker-in-patients-with-chronic-hepatitis-b
#1
Rafiye Ciftciler, Seren Ozenirler, Aysegul Atak Yucel, Mustafa Cengiz, Gulbanu Erkan, Erkan Buyukdemirci, Cemile Sönmez, Guldal Yılmaz Esendaglı
BACKGROUND: Liver biopsy is recommended in the majority of patients with chronic viral hepatitis for fibrosis evaluation. Because of the potential risks of liver biopsy, many studies related to non-invasive biomarkers of hepatic fibrosis have been performed. We aimed to assess the diagnostic value of serum biglycan as a non-invasive fibrosis marker in chronic hepatitis B patients. METHODS: This study included 120 patients with biopsy-proven hepatitis B patients and 60 healthy controls...
December 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27907131/itraq-based-quantitative-proteomic-comparison-of-early-and-late-passage-human-dermal-papilla-cell-secretome-in-relation-to-inducing-hair-follicle-regeneration
#2
Huan Zhang, Ning-Xia Zhu, Keng Huang, Bo-Zhi Cai, Yang Zeng, Yan-Ming Xu, Yang Liu, Yan-Ping Yuan, Chang-Min Lin
Alopecia is an exceedingly prevalent problem that lacks effective therapy. Recently, research has focused on early-passage dermal papilla cells (DPCs), which have hair inducing activity both in vivo and in vitro. Our previous study indicated that factors secreted from early-passage DPCs contribute to hair follicle (HF) regeneration. To identify which factors are responsible for HF regeneration and why late-passage DPCs lose this potential, we collected 48-h-culture medium (CM) from both of passage 3 and 9 DPCs, and subcutaneously injected the DPC-CM into NU/NU mice...
2016: PloS One
https://www.readbyqxmd.com/read/27886664/degradation-behaviors-of-geometric-cues-and-mechanical-properties-in-a-3d-scaffold-for-tendon-repair
#3
Yang Wu, Yoke San Wong, Jerry Ying Hsi Fuh
A three-dimensional (3D) scaffold fabricated via electrohydrodynamic jet printing (E-jetting) and thermally uniaxial stretching, has been developed for tendon tissue regeneration in our previous study. In this study, more in-depth biological test showed that the aligned cell morphology guided by the anisotropic geometries of the 3D tendon scaffolds, leading to up-regulated tendious gene expression including collagen type I, decorin, tenascin-C and biglycan, as compared to the electrospun scaffolds. Given the importance of geometric cues to the biological function of the scaffolds, the degradation behaviors of the 3D scaffolds were investigated...
November 25, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27860287/proteoglycan-neofunctions-regulation-of-inflammation-and-autophagy-in-cancer-biology
#4
Liliana Schaefer, Claudia Tredup, Maria A Gubbiotti, Renato V Iozzo
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes...
November 17, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27849015/sterile-inflammation-as-a-factor-in-human-male-infertility-involvement-of-toll-like-receptor-2-biglycan-and-peritubular-cells
#5
C Mayer, M Adam, L Glashauser, K Dietrich, J U Schwarzer, F-M Köhn, L Strauss, H Welter, M Poutanen, A Mayerhofer
Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), orchestrate inflammatory events and that Toll like receptors (TLRs) and danger signals from the extracellular matrix (ECM) of this wall are involved. In cultured HTPCs we detected TLRs, including TLR2. A TLR-2 ligand (PAM) augmented interleukin 6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and pentraxin 3 (PTX3) in HTPCs...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789290/ablation-of-biglycan-attenuates-cardiac-hypertrophy-and-fibrosis-after-left-ventricular-pressure-overload
#6
Nadine Beetz, Carolin Rommel, Tilman Schnick, Elena Neumann, Achim Lother, Elsa Beatriz Monroy-Ordonez, Martin Zeeb, Sebastian Preissl, Ralf Gilsbach, Ariane Melchior-Becker, Bartosz Rylski, Monika Stoll, Liliana Schaefer, Friedhelm Beyersdorf, Brigitte Stiller, Lutz Hein
AIMS: Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role in stabilizing fibrotic scars after experimental myocardial infarction. However, the role of biglycan in the development and regression of cardiomyocyte hypertrophy and fibrosis during cardiac pressure overload and unloading remains elusive. Thus, the aim of the present study was to assess the effect of biglycan on cardiac remodeling in a mouse model of left ventricular pressure overload and unloading...
October 24, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27742920/strenuous-treadmill-running-induces-a-chondrocyte-phenotype-in-rat-achilles-tendons
#7
Shao-Yong Xu, Shu-Fen Li, Guo-Xin Ni
BACKGROUND Although tendinopathy is common, its underlying pathogenesis is poorly understood. This study aimed to investigate the possible pathogenesis of tendinopathy. MATERIAL AND METHODS In this study, a total of 24 rats were randomly and evenly divided into a control (CON) group and a strenuous treadmill running (STR) group. Animals in the STR group were subjected to a 12-week treadmill running protocol. Subsequently, all Achilles tendons were harvested to perform histological observation or biochemical analyses...
October 15, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27716343/high-levels-of-biomarkers-of-collagen-remodeling-are-associated-with-increased-mortality-in-copd-results-from-the-eclipse-study
#8
Jannie M B Sand, Diana J Leeming, Inger Byrjalsen, Asger R Bihlet, Peter Lange, Ruth Tal-Singer, Bruce E Miller, Morten A Karsdal, Jørgen Vestbo
BACKGROUND: There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortality in COPD and measured neo-epitopes originating from ECM proteins associated with lung tissue remodeling. METHODS: Biomarkers of ECM remodeling were assessed in a subpopulation (n = 1000) of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) cohort...
October 4, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27687492/single-cell-analysis-reveals-igf-1-potentiation-of-inhibition-of-the-tgf-%C3%AE-smad-pathway-of-fibrosis-in-human-keratocytes-in-vitro
#9
Tomislav Sarenac, Martin Trapecar, Lidija Gradisnik, Marjan Slak Rupnik, Dusica Pahor
Corneal wound healing is often affected by TGF-β-mediated fibrosis and scar formation. Guided fibrosis with IGF-1 and antifibrotic substances might maintain corneal transparency. Primary human corneal keratocytes under serum-free conditions were used as a model of corneal stromal wounding, with markers of corneal fibrosis and opacity studied under TGF-β2 stimulation. Single-cell imaging flow cytometry was used to determine nuclearization of Smad3, and intracellular fluorescence intensity of Smad7 and the corneal crystallin aldehyde dehydrogenase 3A1...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27632686/loss-of-function-mutations-in-the-x-linked-biglycan-gene-cause-a-severe-syndromic-form-of-thoracic-aortic-aneurysms-and-dissections
#10
Josephina A N Meester, Geert Vandeweyer, Isabel Pintelon, Martin Lammens, Lana Van Hoorick, Simon De Belder, Kathryn Waitzman, Luciana Young, Larry W Markham, Julie Vogt, Julie Richer, Luc M Beauchesne, Sheila Unger, Andrea Superti-Furga, Milan Prsa, Rami Dhillon, Edwin Reyniers, Harry C Dietz, Wim Wuyts, Geert Mortier, Aline Verstraeten, Lut Van Laer, Bart L Loeys
PURPOSE: Thoracic aortic aneurysm and dissection (TAAD) is typically inherited in an autosomal dominant manner, but rare X-linked families have been described. So far, the only known X-linked gene is FLNA, which is associated with the periventricular nodular heterotopia type of Ehlers-Danlos syndrome. However, mutations in this gene explain only a small number of X-linked TAAD families. METHODS: We performed targeted resequencing of 368 candidate genes in a cohort of 11 molecularly unexplained Marfan probands...
September 15, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27615609/interleukin-1%C3%AE-induces-focal-degradation-of-biglycan-and-tissue-degeneration-in-an-in-vitro-ovine-meniscal-model
#11
Emily Fuller, Christopher B Little, James Melrose
We have developed an ovine meniscal explant model where the focal degradative events leading to characteristic fragmentation patterns of biglycan in human OA of the knee and hip, and evident in animal models of knee OA and IVD degeneration are reproduced in culture. Lateral and medial menisci were dissected into outer, mid and inner zones and established in explant culture±IL-1 (10ng/ml). The biglycan species present in conditioned media samples and in GuHCl extracts of tissues were examined by Western blotting using two C-terminal antibodies PR-85 and EF-Bgn...
September 9, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27600268/a-novel-biological-function-of-soluble-biglycan-induction-of-erythropoietin-production-and-polycythemia
#12
Helena Frey, Kristin Moreth, Louise Tzung-Harn Hsieh, Jinyang Zeng-Brouwers, Birgit Rathkolb, Helmut Fuchs, Valérie Gailus-Durner, Renato V Iozzo, Martin Hrabě de Angelis, Liliana Schaefer
Secondary polycythemia, a disease characterized by a selective increase in circulating mature erythrocytes, is caused by enhanced erythropoietin (Epo) concentrations triggered by hypoxia-inducible factor-2α (HIF-2α). While mechanisms of hypoxia-dependent stabilization of HIF-2α protein are well established, data regarding oxygen-independent regulation of HIF-2α are sparse. In this study, we generated a novel transgenic mouse model, in which biglycan was constitutively overexpressed and secreted by hepatocytes (BGN (Tg)), thereby providing a constant source of biglycan released into the blood stream...
September 6, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27590684/biglycan-stimulates-vegf-expression-in-endothelial-cells-by-activating-the-tlr-signaling-pathway
#13
Lei Hu, Ming-de Zang, He-Xiao Wang, Jian-Fang Li, Li-Ping Su, Min Yan, Chen Li, Qiu-Meng Yang, Bing-Ya Liu, Zheng-Gang Zhu
Biglycan (BGN) is an important component of the extracellular matrix (ECM) that is implicated in a variety of human cancers. In our previous study, we reported that BGN was overexpressed in gastric cancer (GC) tissues and promoted cancer metastasis. Moreover, the tubular formation capacity in HUVECs was promoted by stimulation with culture media from BGN-overexpressing GC cells, but the exact underlying mechanism is still unknown. The purpose of this study was to determine the role and molecular mechanism of BGN in VEGF expression in endothelial cells...
November 2016: Molecular Oncology
https://www.readbyqxmd.com/read/27585241/biglycan-intensifies-alk5-smad2-3-signaling-by-tgf-%C3%AE-1-and-downregulates-syndecan-4-in-cultured-vascular-endothelial-cells
#14
Takato Hara, Eiko Yoshida, Yasuhiro Shinkai, Chika Yamamoto, Yasuyuki Fujiwara, Yoshito Kumagai, Toshiyuki Kaji
Proteoglycans are macromolecules that consist of a core protein and one or more glycosaminoglycan side chains. A small leucine-rich dermatan sulfate proteoglycan, biglycan, is one of the predominant types of proteoglycans synthesized by vascular endothelial cells; however, the physiological functions of biglycan are not completely understood. In the present study, bovine aortic endothelial cells in culture were transfected with small interfering RNAs for biglycan, and the expression of other proteoglycans was examined...
September 1, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27569372/small-leucine-rich-repeat-proteoglycans-in-corneal-inflammation-and-wound-healing
#15
REVIEW
Jihane Frikeche, George Maiti, Shukti Chakravarti
The small leucine rich repeat proteoglycans are major components of the cornea. Lumican, keratocan, decorin, biglycan and osteoglycin are present throughout the adult corneal stroma, and fibromodulin in the peripheral limbal area. In the cornea literature these proteoglycan have been reviewed as structural, collagen fibril-regulating proteins of the cornea. However, these proteoglycans are members of the leucine-rich-repeat superfamily, and share structural similarities with pathogen recognition toll-like receptors...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27559042/glycoproteomics-reveals-decorin-peptides-with-anti-myostatin-activity-in-human-atrial-fibrillation
#16
Javier Barallobre-Barreiro, Shashi K Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M Shah, Marjan Jahangiri, Liliana Schaefer, Jens W Fischer, Renato V Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya Otsu, Manuel Mayr
BACKGROUND: Myocardial fibrosis is a feature of many cardiac diseases. We used proteomics to profile glycoproteins in the human cardiac extracellular matrix (ECM). METHODS: Atrial specimens were analyzed by mass spectrometry after extraction of ECM proteins and enrichment for glycoproteins or glycopeptides. RESULTS: ECM-related glycoproteins were identified in left and right atrial appendages from the same patients. Several known glycosylation sites were confirmed...
September 13, 2016: Circulation
https://www.readbyqxmd.com/read/27547834/mice-deficient-in-n-acetylgalactosamine-4-sulfate-6-o-sulfotransferase-exhibit-enhanced-liver-fibrosis-and-delayed-recovery-from-fibrosis-in-carbon-tetrachloride-treated-mice
#17
Hiroko Habuchi, Takahiro Ushida, Osami Habuchi
BACKGROUND: Chondroitin/dermatan sulfate (CS/DS) rich in N-acetylgalactosamine 4,6-bissulfate (GalNAc(4,6SO4)) residues is present as decorin and/or biglycan in mouse liver, and GalNAc(4,6SO4) residues disappeared completely in N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) knockout (KO) mice. The aim of this study was to investigate whether CS/DS rich in GalNAc(4,6SO4) residues participate in the progression or resolution of liver fibrosis. METHODS: Wild type (WT) and GalNAc4S-6ST KO mice were treated with CCl4 for 5 weeks...
August 2016: Heliyon
https://www.readbyqxmd.com/read/27543755/proteins-and-their-modifications-in-a-medieval-mummy
#18
Ivan Mikšík, Pavla Sedláková, Statis Pataridis, Federica Bortolotti, Rossella Gottardo
Proteins and their modifications of the natural mummy of Cangrande della Scala (Prince of Verona, Northern Italy, 1291-1329) were studied. The nano-LC-Q-TOF analysis of samples of rib bone and muscle from the mummy showed the presence of different proteins including Types I, III, IV, V, and XI collagen, hemoglobin (subunits alpha and beta), ferritin, biglycan, vitronectin, prothrombin, and osteocalcin. The structure of Type I and Type III collagen was deeply studied to evaluate the occurrence of modifications in comparison with Type I and Type III collagen coming from tissues of recently died people...
November 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27538499/the-proteome-of-normal-human-retrobulbar-optic-nerve-and-sclera
#19
Pingbo Zhang, Rabia Karani, Randi L Turner, Craig Dufresne, Sara Ferri, Jennifer E Van Eyk, Richard D Semba
The optic nerve is a white matter tract that conveys visual information to the brain. The sclera comprises the white, protective outer layer of the eye. A characterization of the proteome of normal human retrobulbar optic nerve and sclera may facilitate studies of the eye. We conducted a proteomic analysis of optic nerve and sclera from five adults. Proteins were fractionated using SDS-PAGE. After in-gel digestion, peptides were analyzed using LC-MS/MS on an Orbitrap Elite mass spectrometer. We identified 2711 non-redundant proteins in retrobulbar optic nerve and 1945 non-redundant proteins in sclera...
October 2016: Proteomics
https://www.readbyqxmd.com/read/27515282/the-cytoprotective-effect-of-biglycan-core-protein-involves-toll-like-receptor-4-signaling-in-cardiomyocytes
#20
Renáta Gáspár, Márton Pipicz, Fatime Hawchar, Dávid Kovács, Luna Djirackor, Anikó Görbe, Zoltán V Varga, Mónika Kiricsi, Goran Petrovski, Attila Gácser, Csaba Csonka, Tamás Csont
AIMS: Exogenously administered biglycan (core protein with high-molecular weight glycosaminoglycan chains) has been shown to protect neonatal cardiomyocytes against simulated ischemia/reperfusion injury (SI/R), however, the mechanism of action is not clear. In this study we aimed to investigate, which structural component of biglycan is responsible for its cardiocytoprotective effect and to further explore the molecular mechanisms involved in the cytoprotection. METHODS AND RESULTS: A pilot study was conducted to demonstrate that both native (glycanated) and deglycanated biglycan can attenuate cell death induced by SI/R in a dose-dependent manner in primary neonatal cardiomyocytes isolated from Wistar rats...
October 2016: Journal of Molecular and Cellular Cardiology
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