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Madhukar Mittal, Rajeev Verma, Arvind Mishra, Ajay Singh, Vivek Kumar, K K Sawlani, M Kaleem Ahmad, Pratishtha Mishra, Rishika Gaur
Background: Homocysteine (HCY) interferes with collagen cross-linking in bones and stimulates osteoclast activity. The activated osteoclasts secrete cathepsin K (CathK), a cysteine protease, in eminent quantity during bone resorption. Hyperhomocysteinemia may effect bone mineral density (BMD) through CathK. We, therefore, examined the relation between HCY and BMD along with CathK, 25-hydroxyvit-D (25[OH]D), intact parathyroid hormone (iPTH), and Vitamin B12. Materials and Methods: We recruited a total of 93 postmenopausal women between the age group of 45-60 years, attending the Endocrinology outpatient department at King George's Medical University, Lucknow...
March 2018: Indian Journal of Endocrinology and Metabolism
Meha Sharma, Urmila Dhakad, Anupam Wakhlu, Danveer Bhadu, Deep Dutta, Siddharth K Das
Background and Objectives: Factors determining bone mineral (BM) loss in rheumatoid arthritis (RA) are not well known. This study aimed to determine the occurrence and predictors of BM loss in the young premenopausal women with RA. Methods: Ninety-six females with RA and 90 matched controls underwent clinical, biochemical, BM density (BMD), and body composition assessments. RA disease activity was assessed using disease activity score-28 (DAS-28) and hand X-ray...
March 2018: Indian Journal of Endocrinology and Metabolism
Joseph W Lozier, Andrew J Niehaus, Andrew Muir, Jeffrey Lakritz
Transfixation pin casts (TPC) may be useful in management of fractures in ruminants. A retrospective study was conducted to report the uses, complications, and outcomes of TPC in ruminant fracture stabilization. Twenty-five cattle, 7 goats, and 7 sheep with long bone fractures managed with TPC met the inclusion criteria. Long-term outcome was assessed from telephone interviews with owners. Thirty-one animals (79%) survived to removal of external coaptation and return to the farm. Common complications included pin-hole osteitis and disuse osteopenia...
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Liting Tong, Jaya Sujatha Gopal-Kothandapani, Amaka C Offiah
Metabolic bone disease of prematurity is characterised by disordered bone mineralisation and is therefore an increased fracture risk. Preterm infants are especially at risk due to incomplete in utero bone accretion during the last trimester. Currently, diagnosing metabolic bone disease mainly relies on biochemistry and radiographs. Dual-energy x-ray absorptiometry and quantitative ultrasound (US) are used less frequently. However, biochemical measurements correlate poorly with bone mineralisation and although scoring systems exist for metabolic bone disease, radiographs are subjective and do not detect early features of osteopenia...
June 16, 2018: Pediatric Radiology
Sakineh Abbasi, Jafar Fatahi Asl, Leila Moein Zadeh, Mohammad Mirdoraghi
The aim of the study is determining bone mineral density (BMD) of Patients with beta thalassemia in order to find the prevalence and related factors on the conditions. Z -Score of femoral neck and lumbar vertebrae were reported comparing normal matched subjects. Age and bone mineral density were significantly correlated. Moreover, the disease had significantly higher severity in men than in women. A negative significant correlation was detected between BMD and the mean of hematocrit in the last 5 years. There was significant differences between sex hormone and bone density...
August 2018: Data in Brief
Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Lavanya Murthy, Vivian Grill, Gustavo Duque
OBJECTIVES: The combination of osteopenia/osteoporosis and sarcopenia (osteosarcopenia) defines a diagnostic subset of individuals at higher risk of falls, fractures and institutionalization. In this study we aimed to assess the potential role of high serum levels of parathyroid hormone (PTH) in osteosarcopenia. We hypothesized that a high PTH level is one of the major determinants of this syndrome. STUDY DESIGN: Cross-sectional study in 400 subjects (mean age = 79, 65% women) assessed between 2009 and 2014 at the Falls and Fractures Clinic, Nepean Hospital (Penrith, Australia)...
July 2018: Maturitas
Shaojun Li, Hongning Jiang, Bo Wang, Mingjun Gu, Xia Bi, Ying Yin, Yu Wang
OBJECTIVE: Pulsed electromagnetic fields (PEMFs) could promote osteogenic differentiation and suppress adipogenic differentiation in bone mesenchymal stem cells ex vivo. However, data on the effect of PEMF on marrow adiposity in humans remain elusive. We aimed to determine the in vivo effect of PEMF on marrow adiposity in postmenopausal women using magnetic resonance spectroscopy. METHODS: Sixty-one postmenopausal women with osteopenia, aged 53 to 85 years, were randomly assigned to receive either PEMF treatment or placebo...
June 12, 2018: Journal of Computer Assisted Tomography
Samantha R Weaver, Hannah P Fricke, Cynthia Xie, Robert J Lipinski, Chad M Vezina, Julia F Charles, Laura L Hernandez
Selective Serotonin Reuptake Inhibitors (SSRIs) have been linked to osteopenia and fracture risk but their long-term impact on bone health is not well understood. SSRIs are widely prescribed to pregnant and breastfeeding women who may be at particular risk for bone pathology because lactation is associated with considerable maternal bone loss. We used microCT and molecular approaches to test whether the SSRI fluoxetine, administered to C57BL/6 mice from conception through the end of lactation, causes persistent maternal bone loss...
June 8, 2018: Endocrinology
Vanessa Ribeiro Dos Santos, Diego Giulliano Destro Christofaro, Igor Conterato Gomes, Ismael Forte Freitas Júnior, Luís Alberto Gobbo
Objective: This study sought to analyze the relationship between the components and aggravations of body composition (obesity, sarcopenia, and sarcopenic obesity) and bone mineral density in elderly subjects aged ≥80 years. Methods: A cross-sectional study design was utilized to assess 128 subjects aged between 80 and 95 years. Body composition and bone mineral density were measured by dual energy X-ray absorptiometry. Gait speed was assessment by walking test...
May 2018: Revista Brasileira de Ortopedia
Yi Pei, Ke Zheng, GuanNing Shang, YuMing Wang, Wei Wang, EnDuo Qiu, ShenLong Li, XiaoJing Zhang
The purpose of this study was to determine whether treatment with strontium ranelate (SrR) can restore bone mass and strength at a skeletal site with established osteopenia in chemotherapy-induced rats. Forty-five Sprague-Dawley male rats were randomly assigned to three study groups (n = 15 rats per group): normal rats (control group), osteopenic rats (chemo group), and osteopenic rats with SrR (chemo-SrR group). We chose a male rat model that mimicked a clinical setting by weekly intravenous injection of cyclophosphamide at 20 mg/kg...
June 7, 2018: Biological Trace Element Research
Snezana Tomasevic-Todorovic, Atina Vazic, Abukari Issaka, Fahad Hanna
Background: Both osteoporosis and osteopenia remain worldwide public health concerns. They both lead to bone fractures, which can lead to disability and burden on those who are afflicted. Objectives: To assess and compare fracture risk between these two groups of patients. Patients and methods: Our cross-sectional study included 82 patients (46 with osteoporosis and 36 with osteopenia) with an average age of 63±9.33 years, who received treatment at the Clinic for Medical Rehabilitation, Clinical Center of Vojvodina in Novi Sad, Serbia...
2018: Open Access Rheumatology: Research and Reviews
Ömür Aktaş, Sena Kaplan, Nebahat Sezer
OBJECTIVES: This study was conducted to assess the relation between bone mineral density (BMD) and clinic-demographic properties and life quality during postmenopausal period. METHODS: The study group consisted of 172 postmenopausal women who applied to the physical therapy and rehabilitation outpatient clinic at a training and research hospital in Ankara, the capital of Turkey. The Survey Form, The 36-item Short Form Health Survey (SF-36) and the FRAX™ were used as data collection tools in this study...
May 21, 2018: Journal of Back and Musculoskeletal Rehabilitation
Nourhène Zammel, Nahed Amri, Rim Chaabane, Tarek Rebai, Riadh Badraoui
This study was assessed to examine whether Zingiber officinale (ZO) can prevent spine disorder and trabecular microarchitecture disruption in osteoporotic murin model. Three groups of male rats were selected: Controls (CTRL), combined model of osteoporosis (CMO), in which rats were orchidectomized and treated with cortisol, and CMO treated with ZO (CMO + ZO). One month after the surgical procedures, the rats were sacrificed. Lumbar curve of the spine has been evaluated using the kyphotic method. The spines were submitted to histological and histomorphometric analysis and mineral (calcium and phosphorus) metabolism assessment...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Eugènia Negredo, Klaus Langohr, Anna Bonjoch, Núria Pérez-Alvárez, Carla Estany, Jordi Puig, Joaquim Rosales, Patricia Echeverría, Bonaventura Clotet, Guadalupe Gómez
Background: Osteoporotic fractures still remain very infrequent and physicians rarely evaluate bone health. We wanted to assess the magnitude of this problem in the near future by determining the risk and likelihood of progression to osteoporosis. Methods: We estimated the risk of progression to osteopenia/osteoporosis among HIV-infected patients with at least 2 DXA scans (3726 scans from 875 patients). Time-non-homogeneous bidirectional multistate models based on three states (normal bone mineral density, osteopenia and osteoporosis) were used to model the progression of bone mineral density as a function of age and to study the association between the risk of bone loss and antiretroviral use...
June 1, 2018: Journal of Antimicrobial Chemotherapy
Ruili Yang, Tingting Yu, Xiaoxing Kou, Xiang Gao, Chider Chen, Dawei Liu, Yanheng Zhou, Songtao Shi
Ten-eleven translocation (Tet) family-mediated DNA oxidation represents an epigenetic modification capable of converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which regulates various biological processes. However, it is unknown whether Tet family affects mesenchymal stem cells (MSCs) or the skeletal system. Here we show that depletion of Tet1 and Tet2 results in impaired self-renewal and differentiation of bone marrow MSCs (BMMSCs) and a significant osteopenia phenotype. Tet1 and Tet2 deficiency reduces demethylation of the P2rX7 promoter and downregulates exosome release, leading to intracellular accumulation of miR-297a-5p, miR-297b-5p, and miR-297c-5p...
June 1, 2018: Nature Communications
Aleksandra Konarzewska, Anna Korzon-Burakowska, Ludomira Rzepecka-Wejs, Iwona Sudoł-Szopińska, Edyta Szurowska, Michał Studniarek
One of significant challenges faced by diabetologists, surgeons and orthopedists who care for patients with diabetic foot syndrome is early diagnosis and differentiation of bone structure abnormalities typical of these patients, i.e. osteitis and Charcot arthropathy. In addition to clinical examination, the patient's medical history and laboratory tests, imaging plays a significant role. The evaluation usually begins with conventional radiographs. In the case of osteomyelitis, radiography shows osteopenia, lytic lesions, cortical destruction, periosteal reactions as well as, in the chronic phase, osteosclerosis and sequestra...
March 2018: Journal of Ultrasonography
Lijun Xu, Lixia Zhang, Zhifang Wang, Chong Li, Shan Li, Li Li, Qianying Fan, Lili Zheng
Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficiency-induced osteoporosis by focusing on osteoblast differentiation. 12-week-old female C57BL/6J mice were ovariectomized (OVX) and intraperitoneally injected with 10 or 50 mg/kg of melatonin for 8 weeks...
May 26, 2018: Calcified Tissue International
Mohammed S Shaheen, Jonathan I Silverberg
No abstract text is available yet for this article.
May 22, 2018: Journal of the American Academy of Dermatology
Azra Memon, Woon Kyu Lee
Krüppel-like factor 10 (KLF10), originally named TGF-β (Transforming growth factor beta) inducible early gene 1 (TIEG1), is a DNA-binding transcriptional regulator containing a triple C2H2 zinc finger domain. By binding to Sp1 (specificity protein 1) sites on the DNA and interactions with other regulatory transcription factors, KLF10 encourages and suppresses the expression of multiple genes in many cell types. Many studies have investigated its signaling cascade, but other than the TGF-β/Smad signaling pathway, these are still not clear...
May 25, 2018: Cancers
Kellie L Hawkins, Long Zhang, Derek K Ng, Keri N Althoff, Frank J Palella, Lawrence A Kingsley, Lisa P Jacobson, Joseph B Margolick, Jordan E Lake, Todd T Brown, Kristine M Erlandson
OBJECTIVE: The relationships between frailty and body composition in older adults with HIV infection are poorly understood. We sought to describe associations between frailty and measures of body composition among adult men with HIV and without HIV. DESIGN/METHODS: Men with and without HIV (age 50-69 years) in the Multicenter AIDS Cohort Study (MACS) Bone Strength Substudy were included if evaluated for frailty (by Fried phenotype) and body composition [BMI, waist circumference, abdominal visceral (VAT) and subcutaneous (SAT) adipose tissue, sarcopenia, and osteopenia/osteoporosis]...
June 19, 2018: AIDS
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