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Osteopenia

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https://www.readbyqxmd.com/read/28431912/osteosarcopenic-obesity-prevalence-and-relation-with-frailty-and-physical-performance-in-middle-aged-and-older-women
#1
Claudia Szlejf, Lorena Parra-Rodríguez, Oscar Rosas-Carrasco
OBJECTIVES: The aims of this study were to determine the prevalence of osteosarcopenic obesity (OSO) and to investigate its association with frailty and physical performance in Mexican community-dwelling middle-aged and older women. DESIGN: Cross-sectional analysis of a prospective cohort. SETTING: The FraDySMex study, a 2-round evaluation of community-dwelling adults from 2 municipalities in Mexico City. PARTICIPANTS: Participants were 434 women aged 50 years or older, living in the designated area in Mexico City...
April 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28431451/-experience-with-the-hind-foot-relaxation-boot
#2
Hans Zwipp, Michael Borrmann, Eberhard Walter
The goal of this paper is to report our experience with hindfoot fractures using our specially developed boot, with a follow-up of 557 cases. This boot works like the well-known Allgöwer-Röck ortheses (ARO), but is a hybrid between a boot and an orthesis. It allows full weightbearing without using crutches and completely protects an acutely operated hind foot fracture, hind foot arthrodesis or a hind foot fracture which is suitable for conservative treatment. In its first generation, this boot was custom made and used in 408 cases, from March 1999 to February 2011...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28429557/use-of-dual-energy-x-ray-absorptiometry-the-trabecular-bone-score-and-quantitative-computed-tomography-in-the-evaluation-of-chronic-kidney-disease-mineral-and-bone-disorders
#3
Nicholas Pocock
In subjects with chronic kidney disease (CKD) who suffer a minimal trauma fracture, the problem is to differentiate between osteoporosis and the various forms of renal bone disease associated with CKD-mineral and bone disorder. This problem is exacerbated by the fact that renal osteodystrophy may coexist with osteoporosis. The World Health Organization's bone mineral density (BMD) criteria for osteopenia ( -2.5 < T-score < -1.0) and osteoporosis (a T-score ≤ -2.5) may be used in patients with CKD stages 1-3...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28429336/effects-of-a-curcumin-based-supplementation-in-asymptomatic-subjects-with-low-bone-density-a-preliminary-24-week-supplement-study
#4
A Riva, S Togni, L Giacomelli, F Franceschi, R Eggenhoffner, B Feragalli, G Belcaro, M Cacchio, H Shu, M Dugall
OBJECTIVE: Osteopenia is a chronic bone condition characterized by decreased calcification, density, or bone mass that, if untreated, can lead to osteoporosis and bone fractures. Although its increasing prevalence, nowadays osteopenia is not adequately prevented and managed. In this study, we evaluated the efficacy, in term of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density. PATIENTS AND METHODS: 57 otherwise healthy subjects with low bone density were enrolled in this pilot, supplement study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28428364/role-of-oestrogen-receptor-signaling-in-skeletal-response-to-leptin-in-female-ob-ob-mice
#5
Russell T Turner, Kenneth A Philbrick, Amida Kuah, Adam J Branscum, Urszula T Iwaniec
Leptin, critical in regulation of energy metabolism, is also important for normal bone growth, maturation and turnover. Compared to wild type (WT) mice, bone mass is lower in leptin-deficient ob/ob mice; osteopenia in growing ob/ob mice is due to decreased bone accrual, and is associated with reduced longitudinal bone growth, impaired cancellous bone maturation and increased marrow adipose tissue (MAT). However, leptin deficiency also results in gonadal dysfunction, disrupting production of gonadal hormones which regulate bone growth and turnover...
April 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28426535/frailty-in-hiv-infected-people-a-new-risk-factor-for-bone-mineral-density-loss
#6
Sylvie Bregigeon, Anne Galinier, Olivia Zaegel-Faucher, Carla E Cano, Véronique Obry, Hélène Laroche, Sophie Trijau, Armelle Saout, Isabelle Poizot-Martin
OBJECTIVE: This study aims to assess the association between bone mineral density (BMD) and frailty in a cohort of HIV-infected patients. DESIGN: A cross-sectional study in an HIV outpatient unit where nearly 1,000 patients are monitored. METHODS: Subjects undergoing bone densitometry were proposed an evaluation of frailty using criteria of the Cardiovascular Health Study (CHS) and the Study of Osteoporotic Fractures (SOF). Frailty markers (FM) were weight-loss, self-reported exhaustion, physical activity, grip strength, chair stands, and slow gait...
April 19, 2017: AIDS
https://www.readbyqxmd.com/read/28423480/the-effect-of-high-dose-vitamin-d-supplementation-on-muscular-function-and-quality-of-life-in-postmenopausal-women-a-randomized-controlled-trial
#7
G Grimnes, N Emaus, K D Cashman, R Jorde
OBJECTIVE: Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as the possible muscular effects of Single Nucleotide Polymorphisms (SNPs) in genes encoding vitamin D-related enzymes. DESIGN: A 12-month randomized, double-blind, controlled trial where the participants received daily elemental calcium (1,000 mg) plus vitamin D3 (800 IU)...
April 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28416169/pathologic-fracture-of-the-thoracic-spine-in-a-male-master-ultra-marathoner-due-to-the-combination-of-a-vertebral-hemangioma-and-osteopenia
#8
Beat Knechtle, Pantelis T Nikolaidis, Bruno Lutz, Thomas Rosemann, Christian B Baerlocher
Vertebral hemangiomas are the most common benign vertebral neoplasms and are generally asymptomatic. In the present study, we report the case of a 52-year-old male master ultra-marathoner suffering from a pathologic fracture of the thoracic spine due to a vertebral hemangioma. A further examination in the athlete revealed an accompanying osteopenia, which was most likely due to a deficiency in both vitamin D and testosterone. The treatment of the fracture consisted of percutaneous vertebroplasty. Shortly after the operation the athlete was able to continue running...
March 27, 2017: Medicina
https://www.readbyqxmd.com/read/28414853/-excessive-osteoporosis-screening-in-women-under-65-years-a-cross-sectional-study
#9
María de Las Nieves Ganiele, Sergio Adrián Terrasa, Karin Silvana Kopitowski
Overuse of osteoporosis screening in women at low risk of fracture may lead to overdiagnosis, inappropriate treatment and medicalization. The objective of this work was to estimate the proportion of women aged 45 to 64 enrolled in a private health insurance plan in Buenos Aires undergoing hip dual-energy x-ray absorptiometry (DXA) in 2011 without meeting osteoporosis screening criteria. In this cross-sectional study, 4310 women of this age range that had undergone a hip DXA were identified. A randomly selected sub-group of 401 women was then assessed for the presence of risk factors for osteoporosis and complete data were retrieved for 178 women...
July 2016: Salud Colectiva
https://www.readbyqxmd.com/read/28409528/vertebral-bone-marrow-diffusivity-in-normal-adults-with-varying-bone-densities-at-3t-diffusion-weighted-imaging
#10
Jie He, Hao Fang, Xiao Na Li
Background There has been controversy surrounding the relationship between diffusivity and bone mineral density (BMD) in vertebral bone marrow. Moreover, sex-related differences of vertebral bone marrow diffusivity in relation to varying bone densities have not yet been evaluated. Purpose To prospectively investigate the role of diffusion-weighted imaging (DWI) in assessing vertebral marrow changes in normal adults with varying bone densities. Material and Methods A total of 124 normal adult volunteers were enrolled in this study...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28397058/clinical-and-biochemical-heterogeneity-between-patients-with-glycogen-storage-disease-type-ia-the-added-value-of-cusum-for-metabolic-control
#11
Fabian Peeks, Thomas A H Steunenberg, Foekje de Boer, M Estela Rubio-Gozalbo, Monique Williams, Rob Burghard, Fabienne Rajas, Maaike H Oosterveer, David A Weinstein, Terry G J Derks
OBJECTIVE: To study heterogeneity between patients with glycogen storage disease type Ia (GSD Ia), a rare inherited disorder of carbohydrate metabolism caused by the deficiency of glucose-6-phosphatase (G6Pase). STUDY DESIGN: Descriptive retrospective study of longitudinal clinical and biochemical data and long-term complications in 20 GSD Ia patients. We included 11 patients with homozygous G6PC mutations and siblings from four families carrying identical G6PC genotypes...
April 10, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28396251/gene-expression-profiling-of-bone-marrow-mesenchymal-stem-cells-from-osteogenesis-imperfecta-patients-during-osteoblast-differentiation
#12
Carla Martins Kaneto, Patrícia S Pereira Lima, Karen Lima Prata, Jane Lima Dos Santos, João Monteiro de Pina Neto, Rodrigo Alexandre Panepucci, Houtan Noushmehr, Dimas Tadeu Covas, Francisco José Alburquerque de Paula, Wilson Araújo Silva
Mesenchymal stem cells (MSCs) are precursors present in adult bone marrow that are able to differentiate into osteoblasts, adipocytes and chondroblasts that have gained great importance as a source for cell therapy. Recently, a number of studies involving the analysis of gene expression of undifferentiated MSCs and of MSCs in the differentiation into multiple lineage processes were observed but there is no information concerning the gene expression of MSCs from Osteogenesis Imperfecta (OI) patients. Osteogenesis Imperfecta is characterized as a genetic disorder in which a generalized osteopenia leads to excessive bone fragility and severe bone deformities...
April 7, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28394689/underlying-adenocarcinoma-of-the-lung-metastasizing-to-the-proximal-phalanx-of-the-foot-causing-complex-regional-pain-syndromea-case-report
#13
Sam Bazrafshan, Maria Pacheco, Julio C Ortiz
We report an unusual case of adenocarcinoma of the lung metastasizing to the proximal phalanx of the third digit in a 56-year-old woman with overlying complex regional pain syndrome. The patient was initially treated for neuroma, fracture, and neuropathic pain with no improvement over a 4-month period before presenting to the emergency department for left third digit pain. Radiographic imaging showed substantial osteopenia and mottling; magnetic resonance imaging demonstrated an aggressive lesion to the proximal phalanx...
March 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28382631/imaging-in-chronic-kidney-disease-metabolic-bone-disease
#14
Anup J Alexander, David Jahangir, Martin Lazarus, Stuart M Sprague
Musculoskeletal manifestations in chronic kidney disease (CKD) are the result of a series of complex alterations in mineral metabolism, which has been defined as chronic kidney disease - mineral and bone-related disorder (CKD-MBD). Biochemical assessment and, at times, bone biopsy remains the mainstay of disease assessment, however, radiological imaging is an important adjunct in evaluating disease severity. This review aims to illustrate the radiological features of CKD-MBD, such as secondary hyperparathyroidism, osteomalacia, adynamic bone disease, osteopenia, and extra-skeletal calcifications...
April 5, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28365811/disuse-osteopenia-induced-by-botulinum-toxin-is-similar-in-skeletally-mature-young-and-aged-female-c57bl-6j-mice
#15
Jens Bay Vegger, Annemarie Brüel, Mikkel Bo Brent, Jesper Skovhus Thomsen
Osteopenia and osteoporosis predominately occur in the fully grown skeleton. However, it is unknown whether disuse osteopenia in skeletally mature, but growing, mice resembles that of fully grown mice. Twenty-four 16-week-old (young) and eighteen 44-week-old (aged) female C57BL/6J mice were investigated. Twelve young and nine aged mice were injected with botulinum toxin in one hind limb; the remaining mice served as controls. The mice were euthanized after 3 weeks of disuse. The femora were scanned by micro-computed tomography (µCT) and bone strength was determined by mechanically testing the femoral mid-diaphysis and neck...
April 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28359689/frailty-measure-is-more-predictive-of-outcomes-after-curative-therapy-for-endometrial-cancer-than-traditional-risk-factors-in-women-60-and-older
#16
Jane A Driver, Akila N Viswanathan
OBJECTIVES: To determine if readily obtainable markers of frailty predict disease-free survival (DFS) in elderly women with endometrial cancer treated with curative intent. METHODS: 88 consecutive women≥age 60 treated with surgery, chemotherapy and radiation for stage I-IV endometrial cancer were included. We considered the following health deficits as markers of "frailty": albumin <3.5mg/dL, hemoglobin <10mg/dL, BMI<20kg/m,(2) unintentional weight loss, ECOG performance status ≥2, history of osteopenia or osteoporosis and Charlson comorbidity score...
March 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28359087/glucocorticoids-induce-bone-and-muscle-atrophy-by-tissue-specific-mechanisms-upstream-of-e3-ubiquitin-ligases
#17
Amy Y Sato, Danielle Richardson, Meloney Cregor, Hannah M Davis, Ernie D Au, Kevin McAndrews, Teresa A Zimmers, Jason M Organ, Munro Peacock, Lilian I Plotkin, Teresita Bellido
Glucocorticoid excess, either endogenous with diseases of the adrenal gland, stress, or aging or when administered for immunosuppression, induces bone and muscle loss, leading to osteopenia and sarcopenia. Muscle weakness increases the propensity for falling, which, combined with the lower bone mass, increases the fracture risk. The mechanisms underlying glucocorticoid-induced bone and muscle atrophy are not completely understood. We have demonstrated that the loss of bone and muscle mass, decreased bone formation, and reduced muscle strength, hallmarks of glucocorticoid excess, are accompanied by upregulation in both tissues in vivo of the atrophy-related genes atrogin1, MuRF1, and MUSA1...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28358779/early-identification-and-treatment-of-osteoporosis-in-a-rural-internal-medicine-clinic-a-quasi-experimental-approach-toquality-improvement
#18
J J Jones, Kristina Henry
Osteoporosis affects more than 44 million individuals in the United States annually while disease management continues to fall short of the recommended guidelines. This study institutes a practice change for osteoporosis/osteopenia screening and treatment founded on current evidence-based guidelines. A retrospective chart review was evaluated for current trends in the identification and treatment of osteoporosis/osteopenia in female patients older than 65 years. Data were then compared with identical data collected after implementing an evidence-based osteoporosis guideline tool...
March 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28351509/adequate-calcium-intake-during-long-periods-improves-bone-mineral-density-in-healthy-children-data-from-the-childhood-obesity-project
#19
Ricardo Closa-Monasterolo, Marta Zaragoza-Jordana, Natàlia Ferré, Veronica Luque, Veit Grote, Berthold Koletzko, Elvira Verduci, Fiammetta Vecchi, Joaquin Escribano
BACKGROUND: Bone mineralization can be influenced by genetic factors, hormonal status, nutrition, physical activity and body composition. The association of higher calcium (Ca) intake or Ca supplementation with better bone mineral density (BMD) remains controversial. Furthermore, it has been speculated that maintaining long-term adequate Ca intake rather than having a brief supplementation period is more effective. The aim of the study was to prospectively analyse the influence of adequate Ca intake on BMD at 7 years of age in European children...
March 16, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28347926/neglected-dorsolateral-dislocation-of-the-first-metatarsophalangeal-joint-a-case-report
#20
Omar A Al-Mohrej, Abdulrahman A AlOmair, Yara A Alfehaid, Abubaker A Alsumali, Nader S Al-Kenani
INTRODUCTION: Although the first metatarsophalangeal (MTP) joint is frequently injured, Complete dislocation of the first MTP joint represents a relatively rare traumatic injury. PRESENTATION OF CASE: A 46-year-old gentleman presented with a traumatic first MTP joint dislocation resulting from an automobile accident. Due to coronavirus outbreak in the hospital at that time, patient was referred to another hospital. Six months later, reduction was achieved surgically and fixation of the MTP with K-wires was done...
February 21, 2017: International Journal of Surgery Case Reports
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