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https://www.readbyqxmd.com/read/28734710/use-of-trabecular-bone-score-tbs-as-a-complementary-approach-to-dual-energy-x-ray-absorptiometry-dxa-for-fracture-risk-assessment-in-clinical-practice
#1
Enisa Shevroja, Olivier Lamy, Lynn Kohlmeier, Fjorda Koromani, Fernando Rivadeneira, Didier Hans
Osteoporosis is a common bone disease characterized by low bone mass and altered bone microarchitecture, resulting in decreased bone strength with an increased risk of fractures. In clinical practice, physicians can assess the risk of fracture for a patient based on several risk factors. Some such as age, weight, and history of fractures after 50 years of age, parental fracture, smoking status, and alcohol intake are incorporated into FRAX, an assessment tool that estimates the 10-year probability of hip fracture and major osteoporotic fractures based on the individual's risk factors profile...
July 19, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28732577/cross-calibration-of-the-ge-prodigy-and-idxa-for-the-measurement-of-total-and-regional-body-composition-in-adults
#2
Brian Oldroyd, Laura Treadgold, Karen Hind
Dual-energy X-ray absorptiometry (DXA) body composition measurements are widely performed in both clinical and research settings, and enable the rapid and noninvasive estimation of total and regional fat and lean mass tissues. DXA upgrading can occur during longitudinal monitoring or study; therefore, cross calibration of old and new absorptiometers is required. We compared soft tissue estimations from the GE Prodigy (GE Healthcare, Madison, WI) with the more recent iDXA (GE Healthcare) and developed translational equations to enable Prodigy values to be converted to iDXA values...
July 18, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28725977/the-effect-of-vitamin-d-and-calcium-supplementation-in-pediatric-steroid-sensitive-nephrotic-syndrome
#3
Sushmita Banerjee, Surupa Basu, Ananda Sen, Jayati Sengupta
BACKGROUND: Low serum levels of total 25-hydroxycholecalciferol (25(OH)D) occur in nephrotic syndrome (NS). We aimed to assess the effects of vitamin D3 and calcium supplementation on 25(OH)D levels, bone mineralization, and NS relapse rate in children with steroid-sensitive NS. METHODS: A randomized controlled trial (RCT) was performed in children with steroid-sensitive NS. The treatment group received vitamin D3 (60,000 IU orally, weekly for 4 weeks) and calcium supplements (500 to 1,000 mg/day for 3 months) after achieving NS remission...
July 19, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28725909/skeletal-fluorosis-due-to-fluorocarbon-inhalation-from-an-air-dust-cleaner
#4
Katherine Peicher, Naim M Maalouf
Skeletal fluorosis (SF) is an osteosclerotic metabolic bone disorder caused by excessive ingestion or inhalation of fluoride. SF is extremely rare in developed countries. We report a case of SF due to inhalational abuse from a fluoride-containing air dust cleaner. A 33-year-old man with no past medical history presented with progressively worsening low back pain for 2 years. Physical examination was notable for loss of lumbar lordosis and tenderness over the lumbar spine. Radiographs were notable for uniform generalized osteosclerosis in the long bones, entire spine, rib cage, and pelvic bones, and loss of the normal lumbar curvature...
July 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28724394/development-of-newborn-screening-connect-nbs-connect-a-self-reported-patient-registry-and-its-role-in-improvement-of-care-for-patients-with-inherited-metabolic-disorders
#5
Yetsa Osara, Kathryn Coakley, Aishwarya Devarajan, Rani H Singh
BACKGROUND: Newborn Screening Connect (NBS Connect) is a web-based self-reported patient registry and resource for individuals and families affected by disorders included in the newborn screening panel. NBS Connect was launched in 2012 by Emory University after years of planning and grassroots work by professionals, consumers, and industry. Individuals with phenylketonuria (PKU), maple syrup urine disease (MSUD) or tyrosinemia (TYR) have been recruited through distribution of outreach materials, presentations at parent organization meetings and direct recruitment at clinic appointments...
July 19, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28723934/the-relationship-between-adiposity-and-bone-density-in-u-s-children-and-adolescents
#6
Cecilia Gállego Suárez, Benjamin H Singer, Achamyeleh Gebremariam, Joyce M Lee, Kanakadurga Singer
OBJECTIVE: In adults, obesity has been associated with several health outcomes including increased bone density. Our objective was to evaluate the association between percent body fat and fat mass with bone mineral density (BMD) in a nationally representative population of children and adolescents. STUDY DESIGN: A total of 8,348 participants 8-18 years of age from the National Health and Nutrition Examination Survey (NHANES) 1999-2006 had whole body DXA scans performed...
2017: PloS One
https://www.readbyqxmd.com/read/28712877/bone-mass-microarchitecture-and-strength-are-influenced-by-race-ethnicity-in-young-adult-men-and-women
#7
Kristin L Popp, Julie M Hughes, Adriana Martinez-Betancourt, Matthew Scott, Victoria Turkington, Signe Caksa, Katelyn I Guerriere, Kathryn E Ackerman, Chun Xu, Ginu Unnikrishnan, Jaques Reifman, Mary L Bouxsein
Lower rates of fracture in both Blacks compared to Whites, and men compared to women are not completely explained by differences in bone mineral density (BMD). Prior evidence suggests that more favorable cortical bone microarchitecture may contribute to reduced fracture rates in older Black compared to White women, however it is not known whether these differences are established in young adulthood or develop during aging. Moreover, prior studies using high-resolution pQCT (HR-pQCT) have reported outcomes from a fixed-scan location, which may confound sex- and race/ethnicity-related differences in bone structure...
July 13, 2017: Bone
https://www.readbyqxmd.com/read/28700517/a-longitudinal-assessment-of-bone-mineral-density-and-body-composition-in-competitive-cyclists
#8
Breanne S Baker, Raoul F Reiser
Competitive cycling has been associated with low bone mineral density (BMD); however, BMD is a multifaceted issue. The purpose of this study was to investigate how age (18-49 years), sex, USA Cycling Category (elite-4) and racing type (road and multiple bikes), influenced body composition across a season in competitive cyclists. February marked the preseason, where 42 participants (22 males, 20 females) completed a health history and cycling questionnaire, four day dietary log and a Dual-energy X-ray absorptiometry (DXA) scan and repeated the measures 180±11 days later...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28689248/daily-self-weighing-and-weight-gain-prevention-a-longitudinal-study-of-college-aged-women
#9
Diane L Rosenbaum, Hallie M Espel, Meghan L Butryn, Fengqing Zhang, Michael R Lowe
Daily self-weighing has been suggested as an important factor for weight loss maintenance among samples with obesity. This study is a secondary analysis that examined daily self-weighing in association with weight and body composition outcomes over 2 years among young women with vulnerability for weight gain. Women (N = 294) of varying weight status completed self-weighing frequency questionnaires and weight was measured in the clinic at baseline, 6 months, 1, and 2 years; DXA scans were completed at baseline, 6 months and 2 years...
July 8, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28685278/does-regional-loss-of-bone-density-explain-low-trauma-distal-forearm-fractures-in-men-the-mr-f-study
#10
B C Hanusch, S P Tuck, R J Q McNally, J J Wu, M Prediger, J Walker, J Tang, I Piec, W D Fraser, H K Datta, R M Francis
The pathogenesis of low trauma wrist fractures in men is not fully understood. This study found that these men have lower bone mineral density at the forearm itself, as well as the hip and spine, and has shown that forearm bone mineral density is the best predictor of wrist fracture. INTRODUCTION: Men with distal forearm fractures have reduced bone density at the lumbar spine and hip sites, an increased risk of osteoporosis and a higher incidence of further fractures. The aim of this case-control study was to investigate whether or not there is a regional loss of bone mineral density (BMD) at the forearm between men with and without distal forearm fractures...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28683146/visceral-fat-reference-values-derived-from-healthy-european-men-and-women-aged-20-30-years-using-ge-healthcare-dual-energy-x-ray-absorptiometry
#11
Tomasz Miazgowski, Robert Kucharski, Marta Sołtysiak, Aleksandra Taszarek, Bartosz Miazgowski, Krystyna Widecka
Dual energy X-ray absorptiometry (DXA) is an established technique used in clinical and research settings to evaluate total and regional fat. Additionally, recently developed software allow to quantify visceral adipose tissue (VAT). Currently, there are no reference values available for GE Healthcare DXA systems for VAT. The aim of this study was to develop reference values for VAT in healthy European adults aged 20-30 years using a GE Healthcare Prodigy densitometer along with the dedicated CoreScan application...
2017: PloS One
https://www.readbyqxmd.com/read/28677166/prediction-of-fractures-and-major-cardiovascular-events-in-men-using-serum-osteoprotegerin-levels-the-prospective-strambo-study
#12
Pawel Szulc, Roland Chapurlat, Lorenz C Hofbauer
Fragility fractures and cardiovascular diseases often coincide. However, data on shared risk factors and markers are scarce. Our aim was to assess the independent associations of serum osteoprotegerin (OPG) levels with the risk of fracture and cardiovascular outcomes (acute coronary syndrome, cardiac death) in older men. A cohort of 819 home-dwelling men aged 60-87 was followed prospectively for 8 years. Serum OPG was measured at baseline by ELISA. Bone mineral density (BMD) at femoral neck and Trabecular Bone Score (TBS) were assessed by DXA...
July 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28670536/osteoporosis-in-otherwise-healthy-patients-with-type-2-diabetes-a-prospective-gender-based-comparative-study
#13
Balram Sharma, Hema Singh, Praveen Chodhary, Sanjay Saran, Sandeep Kumar Mathur
BACKGROUND AND OBJECTIVE: Type 2 diabetes mellitus (T2DM) may affect bone loss differentially in adult males and postmenopausal females. We evaluated the prevalence of osteoporosis in otherwise healthy adults with T2DM. MATERIALS AND METHODS: In a cross-sectional study, adults with T2DM, aged 50 years and above, were evaluated for bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) scan at spine and hip. T-score of ≤-2.5 was defined as osteoporosis and score -2...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28667524/low-evaluation-rate-for-osteoporosis-among-patients-presenting-with-a-rib-fracture
#14
Whang Kim, Hyun Sik Gong, Seung Hoo Lee, Jin Woo Park, Kahyun Kim, Goo Hyun Baek
This study in a regional hospital setting found a low evaluation rate for osteoporosis among patients presenting with a rib fracture. Increased emphasis or education for osteoporosis evaluation may be necessary in case of rib fractures. INTRODUCTION: Rib fractures from a low-energy trauma are common in the elderly, and a history of rib fracture has been reported to increase the risk for a subsequent osteoporotic fracture. The purpose of this study was to evaluate how many of the patients presenting with an isolated rib fracture were being evaluated for osteoporosis and the risk for a subsequent fracture...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28662973/assessment-of-bone-mineral-density-at-the-distal-femur-and-the-proximal-tibia-by-dual-energy-x-ray-absorptiometry-in-individualswith-spinal-cord-injury-precision-of-protocol-and-relation-to-injury-duration
#15
Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K Boyd, W Brent Edwards
Spinal cord injury (SCI) is characterized by marked bone loss at the knee, and there is a need for established dual-energy X-ray absorptiometry (DXA) protocols to examine bone mineral density (BMD) at this location to track therapeutic progress and to monitor fracture risk. The purpose of this study was to quantify the precision and reliability of a DXA protocol for BMD assessment at the distal femur and the proximal tibia in individuals with SCI. The protocol was subsequently used to investigate the relationship between BMD and duration of SCI...
June 26, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28662190/bone-tissue-blood-lipids-and-inflammatory-profiles-in-adolescent-male-athletes-from-sports-contrasting-in-mechanical-load
#16
Ricardo R Agostinete, João P Duarte, João Valente-Dos-Santos, Manuel J Coelho-E-Silva, Oscar M Tavares, Jorge M Conde, Carlos A Fontes-Ribeiro, Giancarlo Condello, Laura Capranica, Suziane U Caires, Rômulo A Fernandes
Exploring the effect of non-impact and impact sports is particular relevant to understand the interaction between skeletal muscle and bone health during growth. The current study aimed to compare total and regional bone and soft-tissue composition, in parallel to measurements of blood lipid and inflammatory profiles between adolescent athletes and non-athletes. Anthropometry, biological maturity, dual energy X-ray absorptiometry (DXA) scans, training load and lipid and inflammatory profiles were assessed in a cross-sectional sample of 53 male adolescents (20 non-athletes, 15 swimmers and 18 basketball players) aged 12-19 years...
2017: PloS One
https://www.readbyqxmd.com/read/28652104/quantifying-pelvic-periprosthetic-bone-remodeling-using-dual-energy-x-ray-absorptiometry-region-free-analysis
#17
Andrew M Parker, Lang Yang, Mohsen Farzi, José M Pozo, Alejandro F Frangi, J Mark Wilkinson
The gold standard tool for measuring periprosthetic bone mineral density (BMD) is dual-energy X-ray absorptiometry (DXA). However, resolution of the method is limited due to the aggregation of pixel data into large regions of interest for clinical and statistical analysis. We have previously validated a region-free analysis method (DXA-RFA) for quantitating BMD change at the pixel level around femoral prostheses. Here, we applied the DXA-RFA method to the pelvis, and quantitated its precision in this setting using repeated DXA scans taken on the same day after repositioning in 29 patients after total hip arthroplasty...
June 23, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28650589/immediate-initiation-of-antiretroviral-therapy-for-hiv-infection-accelerates-bone-loss-relative-to-deferring-therapy-findings-from-the-start-bone-mineral-density-substudy-a-randomized-trial
#18
Jennifer F Hoy, Birgit Grund, Mollie Roediger, Ann V Schwartz, John Shepherd, Anchalee Avihingsanon, Sharlaa Badal-Faesen, Stephane de Wit, Simone Jacoby, Alberto La Rosa, Sanjay Pujari, Mauro Schechter, David White, Nicole Wyman Engen, Kristine Ensrud, Peer D Aagaard, Andrew Carr
Both HIV infection and antiretroviral therapy (ART) are associated with lower bone mineral density (BMD) and increased fracture risk. Because the relative contributions of ART and untreated HIV to BMD loss are unclear, it is important to quantify the effect of ART on bone. We compared the effect of early ART initiation (CD4 >500 cells/μL) with deferred ART on change in BMD in the START Bone Mineral Density substudy, a randomized trial evaluating the effect of immediate ART initiation versus deferring ART (to CD4 <350 cells/μL)...
June 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28648836/cortical-and-trabecular-bone-analysis-of-patients-with-high-bone-mass-from-the-barcelona-osteoporosis-cohort-using-3-dimensional-dual-energy-x-ray-absorptiometry-a-case-control-study
#19
Guillermina Orduna, Ludovic Humbert, Roger Fonolla, Jordi Romera, M Lourdes Cos, Aboro Rial, Xavier Nogués, Adolfo Diez-Perez, Leonardo Mellibovsky
High bone mass (HBM), a rare phenotype, can be detected by dual-energy X-ray absorptiometry (DXA) scanning. Measurements with peripheral quantitative computed tomography at the tibia have found increased trabecular bone mineral density and changes in cortical bone density and structure, all of which lead to increased bone strength. However, no studies on cortical and trabecular bone have been performed at the femur. The recently developed 3-dimensional (3D)-DXA software algorithm quantifies the trabecular and cortical volumetric bone mineral density (vBMD) and the anatomical distribution of cortical thickness using routine hip DXA scans...
June 22, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28643356/bimagrumab-improves-body-composition-and-insulin-sensitivity-in-insulin-resistant-subjects
#20
Tania Garito, Ronenn Roubenoff, Marcus Hompesch, Linda Morrow, Katherine Gomez, Daniel Rooks, Charles Meyers, Monte Buchsbaum, Srikanth Neelakantham, Therese Swan, Lee Anne Filosa, Didier Laurent, Olivier Petricoul, Marjorie Zakaria
BACKGROUND: Skeletal muscle is a key mediator of insulin resistance. Bimagrumab, an antibody against activin receptor type II (ActRII), prevents binding of negative muscle regulators, like myostatin, and increases lean mass and decreases fat mass in animal models. OBJECTIVE: We hypothesized that an improving body composition in insulin resistant individuals could enhance insulin sensitivity. METHODS: Sixteen individuals with mean body mass index (BMI) = 29...
June 23, 2017: Diabetes, Obesity & Metabolism
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