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https://www.readbyqxmd.com/read/29677576/early-mortality-in-scn8a-related-epilepsies
#1
Katrine M Johannesen, Elena Gardella, Ingrid Scheffer, Katherine Howell, Douglas M Smith, Ingo Helbig, Rikke S Møller, Guido Rubboli
SCN8A-related epilepsies are often severe developmental and epileptic encephalopathies. Seizures can be treatment resistant, and patients suffer from severe intellectual disability. Reports have suggested that SCN8A-related epilepsies have a high mortality with SUDEP as the major underlying cause. SUDEP is a catastrophic event, and the risk of occurrence should be correctly and carefully discussed with patients and families. We tested the hypothesis of SUDEP as the main cause of death in SCN8A-related epilepsies by reviewing all the currently reported patients with SCN8A...
April 13, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#2
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29677087/military-supplement-perfluorocarbon-gas-transport-an-overview-of-medical-history-with-yet-unrealized-potentials
#3
Bruce D Spiess
Perfluorocarbon (PFCs) compounds have been a hereto fore under realized pharmaceutical class of intravenous emulsions and respiratory adjuvants researched extensively since the late 1970. This review represents an introduction for a series of more detailed lectures/manuscripts that were part of a combined United States collaborative Federal agency meeting in early February, 2017 at Ft Detrick, MD, focused upon potential technologies in development to fulfill a perceived need: "When blood transfusion is not available...
April 19, 2018: Shock
https://www.readbyqxmd.com/read/29676994/sbml-level-3-package-multistate-multicomponent-and-multicompartment-species-version-1-release-1
#4
Fengkai Zhang, Martin Meier-Schellersheim
Rule-based modeling is an approach that permits constructing reaction networks based on the specification of rules for molecular interactions and transformations. These rules can encompass details such as the interacting sub-molecular domains (components) and the states such as phosphorylation and binding status of the involved components. Fine-grained spatial information such as the locations of the molecular components relative to a membrane (e.g. whether a modeled molecular domain is embedded into the inner leaflet of the cellular plasma membrane) can also be provided...
April 20, 2018: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/29676943/impact-of-preoperative-thrombocytopenia-on-the-outcome-after-coronary-artery-bypass-grafting
#5
Wail Nammas, Magnus Dalén, Stefano Rosato, Riccardo Gherli, Daniel Reichart, Giuseppe Gatti, Francesco Onorati, Giuseppe Faggian, Marisa De Feo, Ciro Bancone, Sidney Chocron, Sorosh Khodabandeh, Giuseppe Santarpino, Antonino S Rubino, Daniele Maselli, Saverio Nardella, Antonio Salsano, Tiziano Gherli, Francesco Nicolini, Marco Zanobini, Matteo Saccocci, Karl Bounader, Paola D'Errigo, Tuomas Kiviniemi, Eeva-Maija Kinnunen, Andrea Perrotti, Juhani Airaksinen, Giovanni Mariscalco, Vito G Ruggieri, Fausto Biancari
The impact of thrombocytopenia on postoperative bleeding and other major adverse events after cardiac surgery is unclear. This issue was investigated in a series of patients who underwent isolated coronary artery bypass grafting (CABG) from the prospective, multicenter E-CABG registry. Preoperative thrombocytopenia was defined as preoperative platelet count <150 × 109 /L and it was considered moderate-severe when preoperative platelet count was <100 × 109 /L. Multilevel mixed-effects regression analysis was performed to adjust the effect of thrombocytopenia on outcomes for baseline and operative covariates as well as for interinstitutional differences in patient-blood management...
April 20, 2018: Platelets
https://www.readbyqxmd.com/read/29676710/-incidence-of-incontinence-after-radical-prostatectomy-using-claims-based-data
#6
M H J Schepens, C M P Ziedses des Plantes, D M Somford, J A van Erkelens, R G Cremers, S de Vries, K K H Aben, R Hoekstra, J J C Stienen, B P Wijsman, M B Busstra, J van Limbeek
OBJECTIVE: To determine the effect of radical prostatectomy (RP) hospital volume on the probability of post-RP incontinence. DESIGN: Retrospective research based on claims-based data of health insurers. METHOD: For every patient with RP the probability of incontinence was determined, based on the definition of claims of one or more incontinence pads per day. Casemix corrections were made based on indicators available in claims-data: age, lymph node dissection, and radiotherapy...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676701/single-center-long-term-results-of-pediatric-liver-transplantation
#7
Mohammad Hussein Al Sayyed, Alireza Shamsaeefar, Saman Nikeghbalian, Seyyed Mohsen Dehghani, Ali Bahador, Masood Dehghani, Razieh Rasekh, Siavash Gholami, Bahareh Khosravi, Seyyed Ali Malek Hosseini
OBJECTIVES: Liver replacement continues to be the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the rare donor organs, complex surgical demands, and the necessity to prevent long-term complications. Our objectives were to analyze 16 years of experience in the Shiraz University Organ Transplant Center. MATERIALS AND METHODS: We retrospectively analyzed the records of 752 patients (< 18 years old) who underwent orthotopic liver transplant at our center over a 16-year period...
April 20, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29676696/tentorial-sling-for-microvascular-decompression-in-patients-with-trigeminal-neuralgia-a-description-of-operative-technique-and-clinical-outcomes
#8
Jeffrey A Steinberg, Jayson Sack, Bayard Wilson, David Weingarten, Bob Carter, Alexander Khalessi, Sharona Ben-Haim, John Alksne
OBJECTIVE Trigeminal neuralgia is a debilitating pain disorder most often caused by arterial compression of the trigeminal nerve, although there are other etiologies. Microvascular decompression (MVD) remains the most definitive treatment for this disorder, with cure rates reported between 60% and 80%. Traditional MVD techniques involve a retrosigmoid craniotomy with placement of an inert foreign material, such as Teflon, between the nerve and compressive vessel. Recurrence of trigeminal neuralgia after MVD has been associated with vessel migration, adhesion formation, and arterial pulsation against the Teflon abutting the nerve...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#9
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676691/defining-the-lateral-limits-of-the-endoscopic-endonasal-transtuberculum-transplanum-approach-anatomical-study-with-pertinent-quantitative-analysis
#10
Alberto Di Somma, Jorge Torales, Luigi Maria Cavallo, Jose Pineda, Domenico Solari, Rosa Maria Gerardi, Federico Frio, Joaquim Enseñat, Alberto Prats-Galino, Paolo Cappabianca
OBJECTIVE The extended endoscopic endonasal transtuberculum transplanum approach is currently used for the surgical treatment of selected midline anterior skull base lesions. Nevertheless, the possibility of accessing the lateral aspects of the planum sphenoidale could represent a limitation for such an approach. To the authors' knowledge, a clear definition of the eventual anatomical boundaries has not been delineated. Hence, the present study aimed to detail and quantify the maximum amount of bone removal over the planum sphenoidale required via the endonasal pathway to achieve the most lateral extension of such a corridor and to evaluate the relative surgical freedom...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676632/deployment-related-lung-disease-is-associated-with-abnormal-ventilation-on-cardiopulmonary-exercise-testing-and-with-increased-lung-clearance-index-score
#11
Silpa D Krefft, Eva B Gottschall, Jennifer J Smith, Matthew Strand, Cecile Rose
RATIONALE: An unknown number of post-9/11 military deployers to Iraq and Afghanistan have returned with respiratory symptoms and may be at risk for deployment-related distal lung disease, detected only on surgical lung biopsy. We hypothesized that cardiopulmonary exercise testing and lung clearance index scores would differ significantly between deployers with and without biopsy-proven deployment-related distal lung disease. OBJECTIVES: To assess if there are differences in cardiopulmonary exercise testing and lung clearance index scores between deployers with and without biopsy-proven deployment-related distal lung disease...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676628/increasing-the-resolution-of-chronic-obstructive-pulmonary-disease-definition-lessons-from-a-cohort-with-remote-but-extensive-exposure-to-secondhand-tobacco-smoke
#12
Mehrdad Arjomandi, Siyang Zeng, Paul D Blanc, Warren M Gold
RATIONALE: The Global Initiative for Chronic Obstructive Lung Disease criteria require a ratio of forced expiratory volume in 1 second (FEV1 ) to forced vital capacity (FVC) (FEV1 /FVC) of less than 0.70 for the diagnosis of chronic obstructive pulmonary disease, whereas other criteria emphasize a lower limit of normal approach. However, the use of Global Initiative for Chronic Obstructive Lung Disease (or lower limit of normal) criteria may result in classification of many smokers with respiratory morbidities as not having chronic obstructive pulmonary disease...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676495/insanity-defense-typology
#13
Kimberly P Brown
Much has been written about how to conduct insanity defense evaluations, as well as how to operationalize the legal definitions of insanity. However, the insanity defense has never been categorized by a typology. This article describes a typology of six subtypes of the insanity defense: paranoid self-defense, "but it's mine," erotomanic stalking, deific decree, disorganized, and false report. Knowledge of these subtypes, while not all inclusive, can inform insanity defense evaluations, guide training, and potentially increase the reliability of forensic evaluators' opinions...
April 20, 2018: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/29676475/on-the-ion-pair-dissociation-mechanisms-in-the-small-nacl%C3%A2-h-2-o-6-cluster-a-perspective-from-reaction-path-search-calculations
#14
Toshiyuki Takayanagi, Taiki Nakatomi, Yoshiteru Yonetani
We performed reaction path search calculations for the NaCl·(H2 O)6 cluster using the global reaction route mapping (GRRM) code to understand the atomic-level mechanisms of the NaCl → Na+  + Cl- ionic dissociation induced by water solvents. Low-lying minima, transition states connecting two local minima and corresponding intrinsic reaction coordinates on the potential energy surface are explored. We found that the NaCl distances at the transitions states for the dissociation pathways were distributed in a relatively wide range of 2...
April 20, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29676446/an-approach-on-the-potential-use-of-probiotics-in-the-treatment-of-skin-conditions-acne-and-atopic-dermatitis
#15
REVIEW
Vitória H M Mottin, Edna S Suyenaga
Acne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics. The review was made through bibliographic search of the main databases (Science Direct, PubMed, Scielo, Medline) between September 2015 and June 2016...
April 20, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29676330/lacrimal-punctal-and-peripunctal-involvement-in-calcinosis-cutis
#16
Nandini Bothra, Mohammad Javed Ali, Nikolaos Trakos, Milind N Naik
Calcinosis cutis is a rare metabolic disorder characterized by cutaneous and subcutaneous deposition of insoluble calcium salts. Ocular adnexal involvement is uncommon but mostly seen in males and in the upper eyelid. Solitary lesions are more common than multiple. The treatment of choice is excision biopsy. Histopathological examination provides a definitive diagnosis. Directed systemic investigations help to rule out underlying pathologies and aids further management. The present case reports the punctal and peripunctal involvement in a case of ocular adnexal calcinosis cutis...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676244/resistance-of-bacteria-to-biocides
#17
Jean-Yves Maillard
Biocides and formulated biocides are used worldwide for an increasing number of applications despite tightening regulations in Europe and in the United States. One concern is that such intense usage of biocides could lead to increased bacterial resistance to a product and cross-resistance to unrelated antimicrobials including chemotherapeutic antibiotics. Evidence to justify such a concern comes mostly from the use of health care-relevant bacterial isolates, although the number of studies of the resistance characteristics of veterinary isolates to biocides have increased the past few years...
April 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29676037/dual-layered-film-protected-lithium-metal-anode-to-enable-dendrite-free-lithium-deposition
#18
Chong Yan, Xin-Bing Cheng, Yang Tian, Xiang Chen, Xue-Qiang Zhang, Wen-Jun Li, Jia-Qi Huang, Qiang Zhang
Lithium metal batteries (such as lithium-sulfur, lithium-air, solid state batteries with lithium metal anode) are highly considered as promising candidates for next-generation energy storage systems. However, the unstable interfaces between lithium anode and electrolyte definitely induce the undesired and uncontrollable growth of lithium dendrites, which results in the short-circuit and thermal runaway of the rechargeable batteries. Herein, a dual-layered film is built on a Li metal anode by the immersion of lithium plates into the fluoroethylene carbonate solvent...
April 20, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29675788/recent-advances-in-tuberculosis-diagnostics-in-resource-limited-settings
#19
REVIEW
Mitsuko Seki, Chang-Ki Kim, Satoshi Hayakawa, Satoshi Mitarai
Smear-negative and drug-resistant cases of tuberculosis (TB) disease necessitate the development of new diagnostic methods, especially in resource-limited settings. To improve the current TB situations, sensitive and specific TB point-of-care tests (POCTs) should be developed. This review addresses the current status of TB, novel diagnostic methodologies for TB, and the impact of those new diagnostics on TB control in such situations. Moreover, the perspective of TB management based on laboratory examinations is described...
April 19, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29675760/comparison-of-efficiency-of-the-retreatment-procedure-between-wave-one-gold-and-wave-one-systems-by-micro-ct-and-confocal-microscopy-an-in-vitro-study
#20
Lyz Cristina Furquim Canali, Jussaro Alves Duque, Rodrigo Ricci Vivan, Clovis Monteiro Bramante, Marcus Vinícius Reis Só, Marco Antonio Hungaro Duarte
INTRODUCTION: To compare, by Micro-CT and confocal laser scanning microscopy (CLSM), the ability of the Wave One Gold and Wave One systems to remove filling material from mesial canals of mandibular molars, effective time spent; quantity of extruded material, and percentage of sealer in the dentinal tubules after retreatment and re-obturation procedures. MATERIALS AND METHODS: Ten first mandibular molars (n = 20 mesial canals) were prepared and filled with gutta-percha and Endofill sealer mixed with Rhodamine B dye using the single cone technique...
April 19, 2018: Clinical Oral Investigations
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