keyword
https://read.qxmd.com/read/38534593/recent-advances-of-chitosan-based-hydrogels-for-skin-wound-dressings
#1
REVIEW
Wei Guo, Xiaoyue Ding, Han Zhang, Zhenzhong Liu, Yanting Han, Qianqian Wei, Oseweuba Valentine Okoro, Amin Shavandi, Lei Nie
The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering the body and positively influence both red blood cell aggregation and platelet adhesion and aggregation in the bloodstream, resulting in a favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as wound dressings due to their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, and soft texture resembling the extracellular matrix...
February 29, 2024: Gels
https://read.qxmd.com/read/38510326/dermal-regeneration-template-in-the-management-and-reconstruction-of-burn-injuries-and-complex-wounds-a-review
#2
JOURNAL ARTICLE
Subhas Gupta, Naiem Moiemen, John P Fischer, Christopher Attinger, Marc G Jeschke, Philippe Taupin, Dennis P Orgill
BACKGROUND: Dermal scaffolds have created a paradigm shift for burn and wound management by providing improved healing and less scarring, while improving cosmesis and functionality. Dermal regeneration template (DRT) is a bilayer membrane for dermal regeneration developed by Yannas and Burke in the 1980s. The aim of this review is to summarize clinical evidence for dermal scaffolds focusing on DRT for the management and reconstruction of burn injuries and complex wounds. METHODS: A comprehensive search of PubMed was performed from the start of indexing through November 2022...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38434722/adipose-mesenchymal-stem-cell-derived-exosomes-promote-skin-wound-healing-in-diabetic-mice-by-regulating-epidermal-autophagy
#3
JOURNAL ARTICLE
Zhe Wang, Haiyue Ren, Peng Su, Feng Zhao, Qiqi Zhang, Xing Huang, Cai He, Quan Wu, Zitong Wang, Jiajie Ma
BACKGROUND: Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly in cases of refractory diabetic wounds. Interestingly, autophagy plays a role in wound healing, and recent research has demonstrated that exosomes are closely associated with intracellular autophagy in biogenesis and molecular signaling mechanisms. Therefore, this study aimed to investigate whether ADSC-Exos promote the repair of diabetic wounds by regulating autophagy to provide a new method and theoretical basis for the treatment of diabetic wounds...
2024: Burns and Trauma
https://read.qxmd.com/read/38420751/beyond-the-burn-an-observational-study-of-cardiovascular-risk-in-burn-survivors-in-the-north-of-iran
#4
JOURNAL ARTICLE
Soroosh Samadi, Arsalan Salari, Mohammadreza Mobayen, Maryam Shakiba, Ali Bazi, Hamid Hojjati, Nafiseh Hekmati Pour, Bahar Farhadi, Hamidreza Alizadeh Otaghvar, Alireza Shirzadi, Mohaya Farzin
Burn survivors experience profound physiological changes following injury, which may have lasting implications for cardiovascular health. This study aims to investigate the cardiovascular risk profile among burn survivors treated at a burn center in northern Iran. This observational study was conducted from 2022 to 2023 at the burn centre affiliated with Guilan University of Medical Sciences, Rasht, Iran. This study assessed a cohort study of 210 burn survivors, focusing on individuals with ≥20% TBSA burn injuries who had recovered and returned to their daily lives...
March 2024: International Wound Journal
https://read.qxmd.com/read/38350788/topical-delivery-of-insulin-using-novel-organogel-formulations-an-approach-for-the-management-of-diabetic-wounds
#5
REVIEW
Sunita Chauhan, Vikas Jhawat, Rahul Pratap Singh, Abhishek Yadav
Diabetes mellitus is a growing chronic form of diabetes, with lengthy health implications. It is predicted as poor diabetic wound recovery affects roughly 25% of all diabetes mellitus patients, frequently resulting in lower traumatic injury and severe external factors and emotional expenses. The insulin-resistant condition increases biofilm development, making diabetic wounds harder to treat. Nowadays, medical treatment and management of diabetic wounds, which have a significant amputation rate, a high-frequency rate, and a high death rate, have become a global concern...
January 15, 2024: Burns
https://read.qxmd.com/read/38317065/the-direct-binding-of-bioactive-peptide-andersonin-w1-to-tlr4-expedites-the-healing-of-diabetic-skin-wounds
#6
JOURNAL ARTICLE
Chao Li, Yuxin Xiong, Zhe Fu, Yuxin Ji, Jiayi Yan, Yan Kong, Ying Peng, Zeqiong Ru, Yubing Huang, Yilin Li, Ying Yang, Li He, Jing Tang, Ying Wang, Xinwang Yang
BACKGROUND: Chronic nonhealing wounds remain a considerable challenge in clinical treatment due to excessive inflammation and impeded reepithelialization and angiogenesis. Therefore, the discovery of novel prohealing agents for chronic skin wounds are urgent and important. Amphibian-derived prohealing peptides, especially immunomodulatory peptides, provide a promising strategy for the treatment of chronic skin trauma. However, the mechanism of immunomodulatory peptides accelerating the skin wound healing remains poorly understood...
February 5, 2024: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/38312740/the-cgas-sting-pathway-a-therapeutic-target-in-diabetes-and-its-complications
#7
REVIEW
Wenjie He, Xingrui Mu, Xingqian Wu, Ye Liu, Junyu Deng, Yiqiu Liu, Felicity Han, Xuqiang Nie
Diabetic wound healing (DWH) represents a major complication of diabetes where inflammation is a key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has emerged as a central mediator of inflammatory responses to cell stress and damage. However, the contribution of cGAS-STING activation to impaired healing in DWH remains understudied. In this review, we examine the evidence that cGAS-STING-driven inflammation is a critical factor underlying defective DWH...
2024: Burns and Trauma
https://read.qxmd.com/read/38303578/thiolation-based-protein-protein-hydrogels-for-improved-wound-healing
#8
JOURNAL ARTICLE
Xing Liu, Zhao Guo, Jie Wang, Wenting Shen, Zhenzhen Jia, Shuang Jia, Limiao Li, Jieqi Wang, Liping Wang, Jiaqi Li, Yinan Sun, Yufang Chen, Min Zhang, Jia Bai, Liyao Wang, Xinyu Li
The limitations of protein-based hydrogels, including their insufficient mechanical properties and restricted biological functions, arise from the highly specific functions of proteins as natural building blocks. A potential solution to overcome these shortcomings is the development of protein-protein hydrogels, which integrate structural and functional proteins. In this study, we introduce a protein-protein hydrogel formed by crosslinking bovine serum albumin (BSA) and a genetically engineered intrinsically disordered collagen-like protein (CLP) through Ag-S bonding...
February 1, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38298888/cadherin-responsive-hydrogel-combined-with-dental-pulp-stem-cells-and-fibroblast-growth-factor-21-promotes-diabetic-scald-repair-via-regulating-epithelial-mesenchymal-transition-and-necroptosis
#9
JOURNAL ARTICLE
Wenjie Lu, Juan Zhao, Xiong Cai, Yutian Wang, Wenwei Lin, Yaoping Fang, Yunyang Wang, Jinglei Ao, Jiahui Shou, Jiake Xu, Sipin Zhu
Diabetes causes a loss of sensation in the skin, so diabetics are prone to burns when using heating devices. Diabetic scalded skin is often difficult to heal due to the microenvironment of high glucose, high oxidation, and low blood perfusion. The treatment of diabetic scald mainly focuses on three aspects: 1) promote the formation of the epithelium; 2) promote angiogenesis; and 3) maintain intracellular homeostasis. In response to these three major repair factors, we developed a cadherin-responsive hydrogel combined with FGF21 and dental pulp stem cells (DPSCs) to accelerate epithelial formation by recruiting cadherin to the epidermis and promoting the transformation of N cadherin to E cadherin; promoting angiogenesis to increase wound blood perfusion; regulating the stability of lysosomal and activating autophagy to maintain intracellular homeostasis in order to comprehensively advance the recovery of diabetic scald...
February 2024: Materials today. Bio
https://read.qxmd.com/read/38284157/immunomodulatory-hydrogels-for-skin-wound-healing-cellular-targets-and-design-strategy
#10
REVIEW
Yinhai He, Ying Cen, Meng Tian
Skin wounds significantly impact the global health care system and represent a significant burden on the economy and society due to their complicated dynamic healing processes, wherein a series of immune events are required to coordinate normal and sequential healing phases, involving multiple immunoregulatory cells such as neutrophils, macrophages, keratinocytes, and fibroblasts, since dysfunction of these cells may impede skin wound healing presenting persisting inflammation, impaired vascularization, and excessive collagen deposition...
January 29, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38281552/silk-fibroin-based-dressings-with-antibacterial-and-anti-inflammatory-properties
#11
JOURNAL ARTICLE
David González-Restrepo, Augusto Zuluaga-Vélez, Lina M Orozco, Juan C Sepúlveda-Arias
Silk fibroin is a fibrillar protein obtained from arthropods such as mulberry and non-mulberry silkworms. Silk fibroin has been used as a dressing in wound treatment for its physical, chemical, mechanical, and biological properties. This systematic review analyzed studies from PubMed, Web of Science, and Scopus databases to identify the molecules preferred for functionalizing silk fibroin-based dressings and to describe their mechanisms of exhibiting anti-inflammatory and antibacterial properties. The analysis of the selected articles allowed us to classify the dressings into different conformations, such as membranes, films, hydrogels, sponges, and bioadhesives...
January 26, 2024: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38261910/a-bioactive-composite-hydrogel-dressing-that-promotes-healing-of-both-acute-and-chronic-diabetic-skin-wounds
#12
JOURNAL ARTICLE
Shunlai Shang, Kaiting Zhuang, Jianwen Chen, Ming Zhang, Shimin Jiang, Wenge Li
Mesenchymal stem cell derived exosomes (MSC-Exos) demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties. Chitosan (CS) exhibits excellent biocompatibility and accelerates cellular migration, adhesion, and proliferation. The ions released from bioactive glass (BG) and titanium dioxide (TiO2 ) nanoparticles exhibit sustained angiogenic and antibacterial potency. In this study, CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan (CMCS), chitosan nanoparticles (CS-NPs), BG, and TiO2 nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects, diabetic wounds, and burn skin injury due to burns...
April 2024: Bioactive Materials
https://read.qxmd.com/read/38250706/exosomal-mir-4645-5p-from-hypoxic-bone-marrow-mesenchymal-stem-cells-facilitates-diabetic-wound-healing-by-restoring-keratinocyte-autophagy
#13
JOURNAL ARTICLE
Yan Shi, Shang Wang, Dewu Liu, Zhengguang Wang, Yihan Zhu, Jun Li, Kui Xu, Furong Li, Huicai Wen, Ronghua Yang
BACKGROUND: Refractory diabetic wounds are a common occurrence in patients with diabetes and epidermis-specific macroautophagy/autophagy impairment has been implicated in their pathogenesis. Therefore, identifying and developing treatment strategies capable of normalizing epidermis-specific macroautophagy/autophagy could facilitate diabetic wound healing. The study aims to investigate the potential of bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) from hypoxic conditions as a treatment to normalize epidermis-specific autophagy for diabetic wound healing...
2024: Burns and Trauma
https://read.qxmd.com/read/38236154/effects-of-nanoparticle-mediated-dihydromyricelin-to-diabetic-wounds-an-in-vivo-study
#14
JOURNAL ARTICLE
Zhao-Nan Wang, Jiu-Cheng Ma, Ming-Fan Xi, Dong Yin, L I-Fan Jiang, Jun Qi
Diabetic wound is one of the serious complications of diabetes, and the wound is persistent and easily recurring, which seriously endangers the health and life of patients. How to effectively promote the healing of diabetic wounds has been a hot spot and difficult area of clinical research. Some previous studies have shown that dihydromyricetin has the effects of regulating blood glucose, controlling the severity and inhibiting scarring. In the present study, we used PLGA nanoparticles as a carrier to load dihydromyricetin to make drug-loaded nanoparticles and applied them dropwise (200 µL) to diabetic mice wounds by topical application to observe the healing and scar formation of diabetic wounds...
January 17, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/38198289/smart-nanofibrous-hydrogel-wound-dressings-for-dynamic-infection-diagnosis-and-control-soft-but-functionally-rigid
#15
JOURNAL ARTICLE
Raj Kumar Sen, Priyanka Prabhakar, Shruti, Priya Verma, Apeksha Vikram, Aradhana Mishra, Ashish Dwivedi, Vijay Sorna Gowri, Jamuna Prasad Chaurasia, Dehi Pada Mondal, Avanish Kumar Srivastava, Neeraj Dwivedi, Chetna Dhand
Chronic wounds, such as burns and diabetic foot ulcers, pose significant challenges to global healthcare systems due to prolonged hospitalization and increased costs attributed to susceptibility to bacterial infections. The conventional use of antibiotic-loaded and metal-impregnated dressings exacerbates concerns related to multidrug resistance and skin argyrosis. In response to these challenges, our research introduces a unique approach utilizing antibiotic-free smart hydrogel wound dressings with integrated infection eradication and diagnostic capabilities...
January 10, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38181905/a-novel-designed-nanofibrous-mat-based-on-hydroxypropyl-methyl-cellulose-incorporating-mango-peel-extract-for-potential-use-in-wound-care-system
#16
JOURNAL ARTICLE
Hanan Adnan Shaker Al-Naymi, Elham Mahmoudi, Marwa M Kamil, Yasir Q Almajidi, Mastafa H Al-Musawi, Vahid Mohammadzadeh, Marjan Ghorbani, Fatemeh Mortazavi Moghadam
Skin tissue is damaged by factors such as burns, physical injuries and diseases namely diabetes. Infection and non-healing of burn wounds and lack of angiogenesis in diabetic wounds lead to extensive injuries and death. Therefore, the design of wound dressings with antibacterial and restorative capabilities is very important. In this study, nanofibers (NFs) including polyurethane (PU) and hydroxypropyl methyl cellulose (HPMC) were prepared with different ratios and Mango peel extract (MPE) loaded into NFs by electrospinning method...
January 3, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38161006/pharmaceutical-applications-of-chitosan-in-skin-regeneration-a-review
#17
REVIEW
Jie Wang, Xunxin Duan, Donghuo Zhong, Mengqi Zhang, Jianying Li, Zhijian Hu, Feng Han
Skin regeneration is the process that restores damaged tissues. When the body experiences trauma or surgical incisions, the skin and tissues on the wound surface become damaged. The body repairs this damage through complex physiological processes to restore the original structural and functional states of the affected tissues. Chitosan, a degradable natural bioactive polysaccharide, has attracted widespread attention partly owing to its excellent biocompatibility and antimicrobial properties; additionally, a modified form of this compound has been shown to promote skin regeneration...
December 29, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38143148/the-hidden-impact-of-neuropathic-pain-after-surgical-fixation-of-wrist-hip-and-ankle-fractures-a-cross-sectional-retrospective-study-evaluating-its-prevalence-and-risk-factors
#18
JOURNAL ARTICLE
Gustavo Waldolato, Janaine Cunha Polese, Robinson Esteves Pires, Felipe Camargos, Rian Portilho, Rafael Waldolato, Amanda A O Leopoldino
BACKGROUND: Dysesthesia, electrical and burning sensations, in addition to allodynia are frequent symptoms of neuropathic pain. Despite the high frequency, scientific data on the development of neuropathic pain after surgery for fracture fixation are scarce. The goal of the present study was to determine the prevalence, risk factors, and evaluate potential associations among neuropathic pain, pain intensity, sociodemographic, and clinical variables after wrist, hip, and ankle fracture fixation...
November 2023: Injury
https://read.qxmd.com/read/38129302/-clinical-efficacy-of-antibiotic-bone-cement-combined-with-vacuum-sealing-drainage-in-treating-diabetes-mellitus-complicated-with-necrotizing-fasciitis
#19
JOURNAL ARTICLE
X F Guo, Z C Jin, X X Deng, Z H Huang, M Y Xue, F Y Bu
Objective: To explore the clinical efficacy of antibiotic bone cement combined with vacuum sealing drainage (VSD) in treating diabetes mellitus complicated with necrotizing fasciitis. Methods: The retrospective observational study approach was used. From January 2020 to March 2022, 12 patients with type 2 diabetes complicated with necrotizing fasciitis who met the inclusion criteria were admitted to Wuxi Ninth People's Hospital, including 7 males and 5 females, aged 27 to 76 years. The initial diagnosis of lesions was in the lower limbs...
December 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/38089434/multifunctional-adm-hydrogel-containing-endothelial-cell-exosomes-for-diabetic-wound-healing
#20
JOURNAL ARTICLE
Kaituo Xiang, Jing Chen, Jiahe Guo, Gongchi Li, Yu Kang, Cheng Wang, Tao Jiang, Maojie Zhang, Guoyong Jiang, Meng Yuan, Xuejiao Xiang, Yingpeng Xu, Sen Ren, Hewei Xiong, Xiang Xu, Wenqing Li, Xiaofan Yang, Zhenbing Chen
Non-healing wound, with limited treatment options, remains a prevalent complication of diabetes mellitus. The underlying causes wherein include oxidative stress injury, bacterial infection, cellular dysfunction, and persistent inflammation. Acellular Dermal Matrix (ADM), a wound dressing composed of natural extracellular matrix and abundant bioactive factors, has been successfully developed to treat various wounds, including burns and diabetic ulcers. Protocatechualdehyde (PA) & trivalent iron ion (Fe3+ ) complex (Fe3+ @PA) exhibits potential antioxidant and antibacterial properties...
December 2023: Materials today. Bio
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