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Burns, wounds, diabetic wounds

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https://www.readbyqxmd.com/read/29691339/outbreak-of-invasive-wound-mucormycosis-in-a-burn-unit-due-to-multiple-strains-of-mucor-circinelloides-f-circinelloides-resolved-by-whole-genome-sequencing
#1
Dea Garcia-Hermoso, Alexis Criscuolo, Soo Chan Lee, Matthieu Legrand, Marc Chaouat, Blandine Denis, Matthieu Lafaurie, Martine Rouveau, Charles Soler, Jean-Vivien Schaal, Maurice Mimoun, Alexandre Mebazaa, Joseph Heitman, Françoise Dromer, Sylvain Brisse, Stéphane Bretagne, Alexandre Alanio
Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015)...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#2
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29664823/incidence-of-cellulitis-in-lower-extremity-burns-6-year-analysis
#3
Joseph N Batac, Roger L Simpson, Catherine J Sinnott, Michael P Catanzaro, Laurence T Glickman
INTRODUCTION: Patients with burn wounds of the lower extremities are at increased risk of developing cellulitis. The probability of developing burn-associated cellulitis is presumed to be correlated with a medical history of diabetes, the etiology of the burn, delay in hospitalization of the patient during their initial presentation, and depth of the burn itself. This study aims to identify factors that place patients at increased risk for developing lower extremity burn wound cellulitis...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29618862/acetic-acid-dressings-finding-the-holy-grail-for-infected-wound-management
#4
Kapil S Agrawal, Anup Vidyadhar Sarda, Raghav Shrotriya, Manoj Bachhav, Vinita Puri, Gita Nataraj
Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. In this study, we have evaluated the use of acetic acid for topical application in the treatment of infected wounds...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29592981/burn-aggravated-infected-wart-in-a-patient-with-type-2-diabetes-a-medical-challenge
#5
Tahseen Ahmed Khan, Mahmood Sheikh, Iqbal Azher, Abdul Khaliq Sheikh
An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Patient then travelled to Saudi Arabia for pilgrimage 3 days later with growth of Staphylococcus aureus and Proteus species in culture and sensitivity report; during his travel, he walked barefoot and the infected wart aggravated with severe burn...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29574036/prognostic-scoring-system-for-patients-undergoing-reconstructive-foot-and-ankle-surgery-for-charcot-neuroarthropathy-the-charcot-reconstruction-preoperative-prognostic-score
#6
David Rettedal, Alissa Parker, Adam Popchak, Patrick R Burns
Charcot neuroarthropathy is a destructive process that occurs in patients with peripheral neuropathy, often due to poorly controlled diabetes mellitus. Surgical reconstruction can be necessary to provide a plantigrade foot that is wound free. A risk of major amputation exists after a Charcot event and after attempted reconstruction. We retrospectively reviewed the data from 34 patients (36 reconstructions) who had undergone reconstructive surgery for Charcot neuroarthropathy. The mean patient age was 56.44 years...
March 21, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29489530/use-of-flir-one-smartphone-thermography-in-burn-wound-assessment
#7
Erica Y Xue, Laurel K Chandler, Stephen L Viviano, Jonathan D Keith
OBJECTIVE: Forward-looking infrared (FLIR) thermography technology uses a handheld camera that measures skin infrared emissivity, captures photographs, and can be analyzed through specialized software. Forward-looking infrared images can be used to analyze and correlate burn wound temperature with burn depth, burn progression, and the number of days needed for healing. FLIR ONE is a miniature, smartphone-compatible thermal imaging camera that has been used to assess inflammation in diabetic foot ulcers, as well as locating perforators in flap surgery...
February 28, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29419365/meek-micrografting-history-indications-technique-physiology-and-experience-a-review-article
#8
Eduardo Camacho Quintero, Jesús Francisco Escrivá Machado, Roger Andres Damian Robles
AIMS: Traumatic loss of skin, particularly in major burns, requires skin grafting to repair the tissue. For a large burn, where donor sites are limited, the skin graft may need to be expanded. In addition, rapid wound closure is a large factor in successful recovery and is usually achieved by debridement and skin grafting. Micrografting was introduced by Meek and involved dividing the skin into small pieces, allowing for up to a tenfold skin expansion. METHODS: We conducted a review of the literature, searched via Medline, Pubmed and Embase (from 1958 to June 2017), searching to identify studies and reports of micrografting...
February 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29406300/a-retrospective-cost-minimization-analysis-of-disposable-and-traditional-negative-pressure-wound-therapy-medicare-paid-claims
#9
Gary Delhougne, Christopher Hogan, Kim Tarka, Sunitha Nair
Traditional negative pressure wound therapy (NPWT) systems are considered durable. The pump is designed for use by numerous patients over a period of several years. Recently developed smaller, disposable devices are designed for single-patient use. A retrospective analysis of 2012-2014 national Medicare claims data was used to examine payments associated with the use of traditional and disposable NPWT systems. Data extracted included NPWT episodes from the Limited Data Set Standard Analytic Files including the 5% sample for traditional NPWT and 100% sample for disposable NPWT...
January 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29394972/extended-islanded-reverse-sural-artery-flap-for-staged-reconstruction-of-foot-defects-proximal-to-toes
#10
Muhammad Amin Yousaf, Zain Ul Abidin, Kamran Khalid, Ata Ul Haq, Farrukh Aslam Khalid, Faraz Ahmad Tarar, Muhammad Umar Asif, Moazzam Nazeer Tarar
Obective:To assess the outcome of extended delayed reverse sural artery flap for reconstruction of foot defects proximal to toes in terms of flap survival, complication and extended area. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from February 2015 to April 2017. METHODOLOGY: Cases who underwent delayed sural artery flap were inducted. Preoperative hand-held doppler was done to confirm the location of perforator...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29368069/effect-of-low-level-laser-therapy-on-the-healing-process-of-donor-site-in-patients-with-grade-3-burn-ulcer-after-skin-graft-surgery-a-randomized-clinical-trial
#11
Reza Vaghardoost, Mahnoush Momeni, Nooshafarin Kazemikhoo, Soheila Mokmeli, Mostafa Dahmardehei, Fereshteh Ansari, Mohammad Ali Nilforoushzadeh, Parisa Sabr Joo, Sara Mey Abadi, Soheila Naderi Gharagheshlagh, Saeed Sassani
Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients...
January 24, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29367872/photoletter-to-the-editor-atypical-primary-cutaneous-mucormycosis-of-the-scalp
#12
Ricardo García-Sepúlveda, Josefina Navarrete-Solís, Hiram Villanueva-Lozano, Rogelio de J Treviño-Rangel, Gloria M González, Jorge Enríquez-Rojas, Javier Molina-Durazo, Roberto Arenas-Guzmán
Mucormycosis of the scalp is a rare cutaneous presentation of the disease. It is also an unusual infection in children. We present the case of a 4-year-old girl with acute lymphoblastic leukemia, who presented with atypical cutaneous mucormycosis simulating an ecthyma gangrenosum lesion. Risk factors for the infection are diabetes, neoplastic diseases, immunosuppression in organ transplant recipients, and neutropenia. The cutaneos forms have been associated with trauma, burns and surgical wounds. First line treatment is amphotericin B...
December 1, 2017: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/29336231/a-new-and-universal-classification-system-of-skin-substitutes-inspired-by-factorial-design
#13
Evan Davison-Kotler, Vaibhav Sharma, Norbert Venantius Kang, Elena García-Gareta
The complexity of the dermal layer of skin means that damage to this section can result in permanent impairment of function. Partial or total dermal loss is a feature of deep burns and chronic wounds such as pressure sores or diabetic ulcers. The issues posed by traditional skin grafts have led to substantial research being carried out in the fields of tissue engineering and biomaterials science to develop a vast array of alternative skin substitutes. Given the large number of different materials, manufacturing methods, and techniques for implementation described for artificial skin substitutes, many classification systems have been created to simplify their categorization...
February 12, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29295546/zinc-in-wound-healing-modulation
#14
REVIEW
Pei-Hui Lin, Matthew Sermersheim, Haichang Li, Peter H U Lee, Steven M Steinberg, Jianjie Ma
Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with current therapies largely focused on supportive care measures. Successful wound repair requires a series of tightly coordinated steps including coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodelling. Zinc is an essential trace element (micronutrient) which plays important roles in human physiology...
December 24, 2017: Nutrients
https://www.readbyqxmd.com/read/29240587/reclaiming-autologous-amputated-tissue-for-limb-salvage-of-a-diabetic-foot-burn-with-underlying-critical-limb-ischemia
#15
Catherine N Tchanque-Fossuo, Andrew M Wishy, Kaitlyn I M West, David L Dawson, Sara E Dahle, John G Carson
BACKGROUND: Diabetes mellitus is a worldwide pandemic that impacts more than 387 million people, with 29 million individuals affected in the United States alone. Diabetic patients have a 25% lifetime risk of developing a diabetic foot ulcer (DFU). Having a DFU is associated with a risk of recurrence approaching 70%. In addition, 1 in 6 patients with DFU will have a lower-limb amputation, with an associated increase in mortality ranging from 47% to 70%. Therefore, limb salvage is critical in patients with DFU...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29210638/medical-applications-of-collagen-and-collagen-based-materials
#16
Anatoly Borisovich Shekhter, Alexey Leonidovich Fayzullin, Marina Nikolaevna Vukolova, Tatyana Georgiyevna Rudenko, Varvara Dmitriyevna Osipycheva, Petr Francevich Litvitsky
Collagen and collagen-based materials have been successfully used in medicine for over 50 years. The number of scientific articles about the role of collagen in the construction of scaffolds for tissue engineering has risen precipitously in recent years. The review contains materials about historic and modern applications of collagen in medicine such as soluble collagen injections, solid constructs reconstructed from solution, and decellularized collagen matrices. The analysis of published data proves the efficacy of collagen material in the treatment of chronic wounds, burns, venous and diabetic ulcers, in plastic, reconstructive and general surgery, urology, proctology, gynecology, ophthalmology, otolaryngology, neurosurgery, dentistry, cardiovascular and bone and cartilage surgery, as well as in cosmetology...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29187917/multi-antibiotic-resistant-extended-spectrum-beta-lactamase-producing-bacteria-pose-a-challenge-to-the-effective-treatment-of-wound-and-skin-infections
#17
Angus Nnamdi Oli, Dennis Emeka Eze, Thaddeus Harrison Gugu, Ifeanyi Ezeobi, Ukamaka Nwakaku Maduagwu, Chibueze Peter Ihekwereme
Introduction: The increasing incidence of antibiotic resistant bacteria is a concern both to the clinicians and the patients due to obvious consequences such as treatment failures, prolonged patients' stay in hospital and nosocomial infections. The choice of the first antibiotic therapy in emergency wards in hospitals is usually not based on patient-specific microbial culture and susceptibility test result.This study is aimed at profiling extended-spectrum beta-lactamase (ESBL) producing bacteria associated with wound injuries and highlighting their multi-antibiotic resistance character...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29178052/prospect-of-using-cell-product-for-the-therapy-of-skin-defects-in-diabetes-mellitus
#18
A P Lykov, N A Bondarenko, O V Poveshchenko, T V Miller, A F Poveshchenko, M A Surovtseva, N P Bgatova, V I Konenkov
The effectiveness of autologous cell product in the therapy of skin burn wounds was studied in C57B1/6 male mice against the background of streptozotocin-induced diabetes mellitus. In animals with and without modeled diabetes mellitus, significant decrease in skin defect area was observed after single administration of the cell product (bone marrow multipotent mesenchymal stromal cells, fibroblasts or media conditioned by these cells).
December 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29109666/prevalence-of-pressure-ulcer-and-nutritional-factors-affecting-wound-closure-success-in-thailand
#19
Supakrit Auiwattanakul, Winai Ungpinitpong, Surakrant Yutthakasemsunt, Supawan Buranapin, Kaweesak Chittawatanarat
Introduction: The authors aimed to estimate the prevalence of pressure ulcers and to explore the nutritional effects of the prognostic factors on successful pressure ulcer closure in a public tertiary care hospital in Thailand. Patients and Methods: The study was a retrospective cohort analysis of seven-year census (2008 - 2014) at Surin hospital in Thailand. There were 424 of total 240,826 patients aged over than 15 years admitted to surgery, orthopedics and medicine wards during the study period with documented pressure ulcers (ICD 10TM)...
September 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29056125/quantification-and-further-refinements-of-dorsal-metacarpal-artery-perforator-flap-for-reconstruction-of-wounds-of-fingers-upto-distal-interphalangeal-joints
#20
Muhammad Amin Yousaf, Zain Ul Abidin, Farrukh Aslam Khalid, Kamran Khalid, Muhammad Saleem, Muhammad Jibran Rabbani, Abdul Malik Mujahid, Moazzam Nazeer Tarrar
OBJECTIVE: To assess the outcome of dorsal metacarpal artery perforator flap for coverage of finger defects extending upto distal interphalangeal joint (DIPJ). STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from March 2015 to May 2017. METHODOLOGY: Our study was carried out in two parts. 1st part of study was to measure average flap length in our population...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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