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https://www.readbyqxmd.com/read/27866791/mesenchymal-stem-cells-the-roles-and-functions-in-cutaneous-wound-healing-and-tumor-growth
#1
REVIEW
Sei-Ichiro Motegi, Osamu Ishikawa
Mesenchymal stem cells (MSCs) are bone marrow-derived non-hematopoietic progenitor cells. MSCs are able to differentiate into various types of cells, including chondrocytes, adipocytes, osteocytes, myocytes, endothelial cells, and keratinocytes. There is increasing evidence that MSCs might be located external to the vasculature, and that perivascular cells in the skin, generally called as "pericytes", might include MSCs. It has been suggested that MSCs localized around blood vessels might migrate into wounds and contribute to the restoration of injured tissues...
November 11, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27808477/the-roles-of-p300-and-creb-in-high-glucose-induced-hif-1%C3%AE-inactivation-under-hypoxia-condition
#2
Lingtao Ding, Minlie Yang, Tianlan Zhao, Guozhong Lv
INTRODUCTION: Given the high prevalence of diabetes and burning injury worldwide, it is essential to dissect the underlying mechanism of delayed burn wound healing in diabetic subjects, especially the high glucose induced HIF-1-mediated transcription defects. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were cultured with low or high concentrations of glucose. HIF-1α induced VEGF transcription was measured via luciferase assay. Immunofluorescence staining was performed to visualize CREB localization...
November 3, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27777549/burn-injuries-and-soft-tissue-traumas-complicated-by-mucormycosis-infection-a-report-of-six-cases-and-review-of-the-literature
#3
E J Kyriopoulos, A Kyriakopoulos, A Karonidis, A Gravvanis, I Gamatsi, C Tsironis, D Tsoutsos
Mucor fungus infection is a rare opportunistic infection, rapidly progressive and often fatal in immunocompromised patients, or in patients with chronic debilitating diseases. We report six cases of trauma patients with mucormycosis. Three had severe thermal burns, one of them with a medical history of diabetes mellitus. The other three patients suffered from severe soft tissue injuries caused by traffic accidents. In all cases there had been spontaneous exposure and contact of the wounds with soil. During hospitalization, fungi cultures and/or biopsies of all wounds were performed and all resulted positive...
December 31, 2015: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27770896/light-induced-antibacterial-activity-of-electrospun-chitosan-based-material-containing-photosensitizer
#4
A N Severyukhina, N V Petrova, A M Yashchenok, D N Bratashov, K Smuda, I A Mamonova, N A Yurasov, D M Puchinyan, R Georgieva, H Bäumler, A Lapanje, D A Gorin
Increasing antimicrobial resistance requires the development of novel materials and approaches for treatment of various infections. Utilization of photodynamic therapy represents an advanced alternative to antibiotics and metal-based agents. Here, we report the fabrication of electrospun material that possesses benefits of both topical antimicrobial and photodynamic therapies. This material combines chitosan, as a biocompatible polymer, and a second generation photosensitizer. The incorporation of photosensitizer doesn't affect the material morphology and its nearly uniform distribution in fibers structure was observed by confocal Raman microscopy...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27765087/-wound-healing-is-still-a-game-of-blind-men-and-an-elephant
#5
C M Han
The wound healing includes non-healing and overhealing of the wounds. The results of wound healing are well known by people such as non-healing of the diabetic ulcer or hypertrophic scar after deep burn. In this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase B/mammalian target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-healing wound...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27695634/phenol-rich-compounds-sweet-gel-a-statistically-more-effective-antibiotic-than-cloxacillin-against-pseudomonas-aeruginosa
#6
Mehrab Dashtdar, Mohammad Reza Dashtdar, Babak Dashtdar, Gazala Afreen Khan, Karima Kardi
OBJECTIVES: The purpose of this study was to obtain a natural antibiotic from Phenol-rich compounds; for the dressing and the treatment of chronic wounds. METHODS: The Phenol-rich compound sweet gel was prepared by blending four natural herbal extracts, Acacia catechu (L.F.), Momia (Shilajit), Castanea sativa, and Ephedra sinica stapf, with combination of a sweet gel medium, including honey, maple saps, Phoenix dactylifera L. (date), pomegranate extract and Azadirachta indica gum as a stabilizer...
September 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/27663454/mice-engrafted-with-human-hematopoietic-stem-cells-support-a-human-myeloid-cell-inflammatory-response-in-vivo
#7
Andrew Baird, Chenliang Deng, Matthew H Eliceiri, Fatima Haghi, Xitong Dang, Raul Coimbra, Todd W Costantini, Bruce E Torbett, Brian P Eliceiri
Mice engrafted with human CD34(+) hematopoietic stem and progenitor cells (CD34(+) -HSPCs) have been used to study human infection, diabetes, sepsis, and burn, suggesting that they could be highly amenable to characterizing the human inflammatory response to injury. To this end, human leukocytes infiltrating subcutaneous implants of polyvinyl alcohol (PVA) sponges were analyzed in immunodeficient NSG mice reconstituted with CD34(+) -HSPCs. It was reported that human CD45(+) (hCD45(+) ) leukocytes were present in PVA sponges 3 and 7 days postimplantation and could be localized within the sponges by immunohistochemistry...
September 24, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27632443/novel-multivalent-wound-healing-ointment-provides-bioburden-control-and-moisture-management-a-retrospective-registry-data-analysis
#8
Thomas Serena, Heather Connell, Sharon McConnell, Keyur Patel, Bryan Doner, Matthew Sabo, Michael Miller, Laura Serena, Lam T Le, David Goldsmith, Jane Chung
OBJECTIVE: The purpose of this retrospective registry data analysis was to explore the effectiveness of a novel multivalent topical ointment (Terrasil Infection Control Wound Care Ointment; Aspiera Medical, Woonsocket, Rhode Island), containing a patented mineral complex and 0.2% benzethonium chloride in the treatment of nonhealing acute and chronic wounds. DESIGN: Aspiera Medical designed a registry to capture physician experiences and treatment results with Terrasil Infection Control Wound Care Ointment...
October 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27617406/burn-wound-mucormycosis-a-case-study-on-poor-wound-healing
#9
Bryan Stanistreet, Derek Bell
Mucormycosis is a rare, rapidly progressive and often fatal fungal infection. The rarity of the condition lends itself to unfamiliarity, delayed treatment, and poor outcomes. Diagnosis of fungal infections early enough to enable appropriate treatment occurs in less than half of affected patients. A 56-year-old male with a history of diabetes mellitus II, hepatitis C, and intravenous drug abuse was involved in a rollover motor vehicle accident. He sustained circumferential partial and full-thickness burns to his lower extremities with 20% BSA burns...
September 9, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27612890/antimicrobial-susceptibility-pattern-of-methicillin-resistance-staphylococcus-aureus-from-different-tertiary-care-hospitals-including-mymensingh-medical-college-hospital
#10
S Roy, M A Hossain, S K Paul, N Haque, T K Barman, S Ahmed, S A Nasreen, M S Hossain, F Ahmed, P Biswas, F Nahar, H Begum, M S Islam
The aim of this study was to detect antimicrobial susceptibilities and the presence of drug resistance genes of MRSA from tertiary care hospitals. This study was carried out in the Department of Microbiology, Mymensingh Medical College during the period from Jan, 2015 to Dec, 2015. Clinical samples, including wound swab, pus, exudates from diabetic ulcer and burn ulcer, aural swab, blood and urine were collected. Standard microbiological procedure & biochemical tests were carried out to detect S. aureus. Oxacillin disk diffusion test was done by Kirby-Bauer disk diffusion method...
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27602254/critical-review-of-noninvasive-optical-technologies-for-wound-imaging
#11
Maanasa Jayachandran, Suset Rodriguez, Elizabeth Solis, Jiali Lei, Anuradha Godavarty
Significance: Noninvasive imaging approaches can provide greater information about a wound than visual inspection during the wound healing and treatment process. This review article focuses on various optical imaging techniques developed to image different wound types (more specifically ulcers). Recent Advances: The noninvasive optical imaging approaches in this review include hyperspectral imaging, multispectral imaging, near-infrared spectroscopy (NIRS), diffuse reflectance spectroscopy, optical coherence tomography, laser Doppler imaging, laser speckle imaging, spatial frequency domain imaging, and fluorescence imaging...
August 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27595452/systematic-review-of-complications-and-outcomes-of-diabetic-patients-with-burn-trauma
#12
A A Sayampanathan
OBJECTIVES: We aimed to understand the effect diabetes plays on the extent of complications and patient outcomes in burn trauma. METHODOLOGY: We searched MEDLINE, Science Direct and the Cochrane Review Database for 571 articles. Through our selection criteria, 12 articles were selected for systematic review and meta-analysis. Data was analysed via Review Manager 5.3, using Mantel-Haenszel statistics and random effect models. RESULTS: The odds of a diabetic patient sustaining a wound or local infection was 2...
August 29, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27564437/posterior-thigh-flap-pedicled-on-the-cutaneous-vessels-arising-from-the-popliteo-posterior-intermediate-artery-a-report-of-5-cases
#13
Xi-Guang Sun, Xu Gong, Liang-Song Song, Jian-Li Cui, Xin Yu, Bin Liu, Lai-Jin Lu
Surgical repair of soft tissue defects of the knee and leg remains challenging. Using a case study approach, the anatomy of the popliteo-posterior intermediate cutaneous artery was examined, and a reverse island flap method was developed and implemented. After obtaining informed consent, 5 patients (1 woman, 4 men, age range 31 to 57 years) underwent the experimental use of a reverse island flap with a posterior thigh flap pedicled on the cutaneous vessels arising from the popliteo-posterior intermediate artery to repair soft-tissue defects of the knee and leg...
August 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/27556755/the-role-of-dermal-matrices-in-treating-inflammatory-and-diabetic-wounds
#14
Mihail Climov, Lauren R Bayer, Andrea V Moscoso, Hajime Matsumine, Dennis P Orgill
BACKGROUND: Dermal matrices are used to improve healing in both acute and chronic wounds including diabetic and lower extremity wounds, burns, trauma, and surgical reconstruction. The use of dermal matrices for the closure of inflammatory ulcerations is less frequent but growing. Currently available products include decellularized dermis and semisynthetic matrices. METHODS: A review of the published literature was performed to identify reports that use acellular dermal matrices in diabetic and inflammatory wounds...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27556754/a-review-of-cellular-and-acellular-matrix-products-indications-techniques-and-outcomes
#15
Olivia B Hughes, Adele Rakosi, Flor Macquhae, Ingrid Herskovitz, Joshua D Fox, Robert S Kirsner
BACKGROUND: Wound healing is a dynamic process whereby cells, growth factors (GFs), and the extracellular matrix (ECM) interact to restore the architecture of damaged tissue. Chronic wounds can be difficult to treat due to the increased presence of inflammatory cells that degrade the ECM, GF, and cells necessary for wound healing to occur. Cellular and acellular matrix products can be used in the management of a variety of chronic wounds including venous, diabetic, and pressure ulcers and other conditions such as burns, epidermolysis bullosa, pyoderma gangrenosum, and surgical wounds...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27549663/mesenchymal-stromal-cells-properties-and-role-in-management-of-cutaneous-diseases
#16
Kevin Kim, Gonzalo Blasco-Morente, Natividad Cuende, Salvador Arias-Santiago
This review describes the current understanding and the potential use of mesenchymal stromal cells (MSCs) in cell-based therapies for clinical management of difficult wounds and other dermatoses. MSCs have been shown to possess many advantageous properties that make them a promising therapeutic modality in dermatology still under investigation. In fact, MSCs' ability to promote wound healing through its paracrine function and pro-angiogenic properties have generated increasing interest for treating acute and chronic wounds...
August 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27493928/health-technology-assessment-on-super-oxidized-water-for-treatment-of-chronic-wounds
#17
Fereshteh Eftekharizadeh, Reza Dehnavieh, Somayeh Noori Hekmat, Mohammad Hossein Mehrolhassani
BACKGROUND: Super oxidized water (SOW), as a novel antiseptic solution, is used with claims of effectiveness and cost effectiveness in healing chronic wounds such as diabetic foot, infectious postoperative ulcers and burn ulcers. We conducted a health technology assessment to evaluate the clinical evidence from clinical and randomized trials for this disinfection. This study aims to evaluate the safety, effectiveness and cost-effectiveness of this technology in Iran, for using as a wound disinfectant...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27487281/low-intensity-ultrasound-therapy-induces-angiogenesis-and-persistent-inflammation-in-the-chronic-phase-of-the-healing-process-of-third-degree-burn-wounds-experimentally-induced-in-diabetic-and-non-diabetic-rats
#18
Marcelo Silva Fantinati, Diego Eterno Oliveira Mendonça, Adriana Márcia Monteiro Fantinati, Bruno Flamarion Dos Santos, Juliana Cristina Oliveira Reis, Cristina Lopes Afonso, Marina Clare Vinaud, Ruy de Souza Lino
PURPOSE: To evaluate the effects of low intensity ultrasound on the healing process of third degree burn wounds in experimentally induced diabetic Wistar rats. METHODS: One hundred rats were divided into: control group; non-diabetic treated group; diabetic control group; diabetic treated group. The therapy was performed with a 3MHz ultrasound application, pulsed emission at 100Hz frequency, modulated at 20% with a dosage of 0.5W/cm2 during three minutes throughout 30 days...
July 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27484929/gastroprotective-potential-of-hydro-alcoholic-extract-of-pattanga-caesalpinia-sappan-linn
#19
David Raj Chellappan, Arun K Purushothaman, Brindha Pemiah
ETHANO-PHARMACOLOGICAL RELEVANCE: Pattanga is botanically equated as Caesalpinia sappan Linn. (Family: Caesalpiniaceae) and is used in Ayurveda system of medicine since ages. According to Ayurveda, useful part is Heartwood, which is bitter, astringent and acrid and is useful in vitiated conditions of vata and pitta, burning sensation, wounds, ulcers, leprosy, skin diseases, menorrhagia, leucorrhea, and diabetes. It is used as a major ingredient in Ayurvedic formulations and preparations like Patrangasava, Chandanadya Thalia, and Karpuradyarka...
July 30, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27450738/thymosin-%C3%AE-4-promotes-dermal-healing
#20
H K Kleinman, G Sosne
No agent has been identified that significantly accelerates the repair of chronic dermal wounds in humans. Thymosin beta 4 (Tβ4) is a small, abundant, naturally occurring regenerative protein that is found in body fluids and inside cells. It was found to have angiogenic and antiinflammatory activity and to be high in platelets that aggregate at the wound site. Thus we used Tβ4 initially in dermal healing. It has since been shown to have many activities important in tissue protection, repair, and regeneration...
2016: Vitamins and Hormones
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