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https://www.readbyqxmd.com/read/29475208/resistance-training-threshold-for-elevating-bone-mineral-density-in-growing-female-rats
#1
Azriel D Dror, Katie Virk, Kassandra Lee, Aaron Gerston, Anuradha Prakash, Marcia J Abbott, S Victoria Jaque, Ken D Sumida
The purpose of this study was to determine the minimum amount of resistance exercise that would stimulate bone formation yielding an elevation in bone mineral density (BMD) during the growth period in female rats. Female rats were randomly divided into: Control (Con, n=8), 3 ladder climb resistance-trained group (3LC, n=8), 4 ladder climb resistance-trained group (4LC, n=8), 5 ladder climb resistance-trained group (5LC, n=8), and 6 ladder climb resistance-trained group (6LC, n=8). All exercised groups were conditioned to climb a vertical ladder with weights appended to their tail 3 days/wk for a total of 6 wks...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29474360/animal-versus-plant-protein-and-adult-bone-health-a-systematic-review-and-meta-analysis-from-the-national-osteoporosis-foundation
#2
Marissa M Shams-White, Mei Chung, Zhuxuan Fu, Karl L Insogna, Micaela C Karlsen, Meryl S LeBoff, Sue A Shapses, Joachim Sackey, Jian Shi, Taylor C Wallace, Connie M Weaver
BACKGROUND: Protein may have both beneficial and detrimental effects on bone health depending on a variety of factors, including protein source. OBJECTIVE: The aim was to conduct a systematic review and meta-analysis evaluating the effects of animal versus plant protein intake on bone mineral density (BMD), bone mineral content (BMC) and select bone biomarkers in healthy adults. METHODS: Searches across five databases were conducted through 10/31/16 for randomized controlled trials (RCTs) and prospective cohort studies in healthy adults that examined the effects of animal versus plant protein intake on 1) total body (TB), total hip (TH), lumbar spine (LS) or femoral neck (FN) BMD or TB BMC for at least one year, or 2) select bone formation and resorption biomarkers for at least six months...
2018: PloS One
https://www.readbyqxmd.com/read/29473973/expression-quantitative-trait-locus-study-of-bone-mineral-density-gwas-variants-in-human-osteoclasts
#3
Benjamin H Mullin, Kun Zhu, Jiake Xu, Suzanne J Brown, Shelby Mullin, Jennifer Tickner, Nathan J Pavlos, Frank Dudbridge, John P Walsh, Scott G Wilson
Osteoporosis is a complex disease with a strong genetic component. Genome-wide association studies (GWAS) have been very successful at identifying common genetic variants associated with bone parameters. A recently published study documented the results of the largest GWAS for bone mineral density (BMD) performed to date (n = 142,487), identifying 307 conditionally independent single-nucleotide polymorphisms (SNPs) as associated with estimated BMD (eBMD) at the genome-wide significance level. The vast majority of these variants are non-coding SNPs...
February 23, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29472917/senescent-t-cells-promote-bone-loss-in-rheumatoid-arthritis
#4
Johannes Fessler, Rusmir Husic, Verena Schwetz, Elisabeth Lerchbaum, Felix Aberer, Patrizia Fasching, Anja Ficjan, Barbara Obermayer-Pietsch, Christina Duftner, Winfried Graninger, Martin Helmut Stradner, Christian Dejaco
Objective: T-cells are critical players in the pathogenesis of osteoporosis in patients with rheumatoid arthritis (RA). Premature senescence of lymphocytes including the accumulation of senescent CD4+ T-cells is a hallmark feature of RA. Whether T-cell senescence is associated with bone loss in RA patients is elusive so far. Methods: This includes a prospective study of consecutive patients with RA ( n  = 107), patients with primary osteopenia/-porosis ( n  = 75), and healthy individuals ( n  = 38)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29471485/trabecular-bone-score-as-an-assessment-tool-to-identify-the-risk-of-osteoporosis-in-axial-spondyloarthritis-a-case-control-study
#5
Kwi Young Kang, Hye Yeon Goo, Sung-Hwan Park, Yeon Sik Hong
Objectives: To compare the trabecular bone score (TBS) between patients with axial spondyloarthritis (axSpA) and matched normal controls and identify risk factors associated with a low TBS. Methods: TBS and BMD were assessed in the two groups (axSpA and control) using DXA. Osteoporosis risk factors and inflammatory markers were also assessed. Disease activity and radiographic progression in the sacroiliac joint and spine were evaluated in the axSpA group. Multivariate linear regression analysis was performed to identify risk factors associated with TBS...
March 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29470854/the-cost-effectiveness-of-screening-in-the-community-to-reduce-osteoporotic-fractures-in-older-women-in-the-uk-economic-evaluation-of-the-scoop-study
#6
David A Turner, Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C Harvey, Richard Holland, Amanda Howe, Eugene McCloskey, Terence W O'Neill, David Torgerson, Richard Fordham
The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470841/disease-duration-and-stage-influence-bone-microstructure-in-patients-with-primary-biliary-cholangitis
#7
Tobias Schmidt, Constantin Schmidt, Felix N Schmidt, Sebastian Butscheidt, Haider Mussawy, Jan Hubert, Thelonius Hawellek, Nicola Oehler, Florian Barvencik, Ansgar W Lohse, Thorsten Schinke, Christoph Schramm, Michael Amling, Tim Rolvien
Primary biliary cholangitis (PBC) is known to be a major risk factor for osteoporosis reflected by a reduction of bone mineral density (BMD). However, both the extent of the macro- and microstructural alterations of bone as well as the causative factors are unknown. We have retrospectively analyzed a total of 96 patients with PBC and 53 healthy controls matched for age, sex and body mass index. In addition to dual-energy X-ray absorptiometry (DXA) measurements at the lumbar spine and hip, high-resolution peripheral quantitative computed tomography (HR-pQCT) was used to assess the geometric, volumetric and microstructural changes of bone at the distal radius and tibia...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470364/resistance-training-is-associated-with-higher-bone-mineral-density-among-young-adult-male-distance-runners-independent-of-physiological-factors
#8
Anthony A Duplanty, Danielle E Levitt, David W Hill, Brian K McFarlin, Nancy M DiMarco, Jakob L Vingren
Low bone mineral density (BMD) in male distance runners is common and could be modulated by a host of biomarkers involved in the dynamic balance of bone tissue. In contrast, resistance training can increase BMD; however, the efficacy of resistance training in protecting BMD in distance runners has not been elucidated. OBJECTIVE: To investigate the relationship between resistance training, testosterone and bone metabolism biomarker concentrations, and BMD in young adult male distance runners...
February 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29469187/the-prediction-of-cyclic-proximal-humerus-fracture-fixation-failure-by-various-bone-density-measures
#9
Peter Varga, Leonard Grünwald, Markus Windolf
Fixation of osteoporotic proximal humerus fractures has remained challenging, but may be improved by careful pre-operative planning. The aim of this study was to investigate how well the failure of locking plate fixation of osteoporotic proximal humerus fractures can be predicted by bone density measures assessed with currently available clinical imaging (realistic case) and a higher resolution and quality modality (theoretical best-case). Various density measures were correlated to experimentally assessed number of cycles to construct failure of plated unstable low-density proximal humerus fractures (N = 18)...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29469014/effect-of-mineral-status-and-glucocorticoid-use-on-bone-mineral-density-in-patients-with-crohn-s-disease
#10
Nayane R Pierote, Amanda F Braz, Susy L Barros, José M Moita Neto, José Miguel L Parente, Maria da Cruz M Silva, Mayara S Beserra, Nina Rosa M Soares, Dilina N Marreiro, Nadir do Noscimento Nogueira
OBJECTIVES: Crohn's disease (CD) is a condition that is characterized by chronic inflammation. The presence of multifactorial pathogenesis that results from inflammation is associated with low micronutrient consumption and glucocorticoid use, which may be related to bone health. This study aimed to evaluate the relationship between dietary mineral intake and glucocorticoid use in bone mineral density (BMD) in patients with CD. METHODS: A cross-sectional study of 62 patients with CD ages 20 y to 40 y measured their macro- and micronutrient intake with a 3-d food record...
November 27, 2017: Nutrition
https://www.readbyqxmd.com/read/29468478/does-trabecular-bone-score-tbs-improve-the-predictive-ability-of-frax-%C3%A2-for-major-osteoporotic-fractures-according-to-the-japanese-population-based-osteoporosis-jpos-cohort-study
#11
Junko Tamaki, Masayuki Iki, Yuho Sato, Renaud Winzenrieth, Etsuko Kajita, Sadanobu Kagamimori
This study examined whether bone microarchitecture determined by Trabecular Bone Score (TBS) is associated with the risk of major osteoporotic fractures independent of FRAX® in Japanese women. Participants included 1541 women aged ≥ 40 at baseline. Major osteoporotic fractures during a 10-year follow-up period were documented by the Japanese Population-based Osteoporosis Cohort Study. TBS and areal bone mineral density (aBMD) were calculated for the same spinal regions at baseline. To compare the predictive ability of FRAX® model when used alone versus in combination with TBS, Akaike information criterion (AIC), the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated...
February 21, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29468105/smaller-radius-width-in-women-with-distal-radius-fractures-compared-to-women-without-fractures
#12
Gary Kiebzak, Walter R Sassard
Introduction Bone mineral density (BMD) measured using dual-energy x-ray absorptiometry (DXA) is typically used to assess fracture risk. However, other factors such as bone size and the forward momentum of a fall (a function of body size) can also potentially influence fracture risk, but are understudied. This report describes the characteristics of a cohort of Caucasian pre- and postmenopausal women with distal radius fractures (DRF) after falling onto an outstretched hand. Methods The fracture cohort comprised entries in an institutional review board-approved registry of study patients who had had DXA scans...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29466196/-issues-of-adipokine-regulation-in-idiopathic-pulmonary-arterial-hypertension-and-systemic-osteopenia
#13
E A Kochetkova, V A Nevsorova, L G Ugay, Y V Maystrovskaya, T A Brodskaya
PURPOSE: to determine the role of adipokines and vascular remodeling in formation of osteoporosis in idiopathic pulmonary arterial hypertension (IPAH). MATERIALS AND METHODS: Functional and hemodynamic parameters, bone mineral density (BMD) T-score in lumbar spine (LS) and femoral neck (FN), blood serum levels of leptin, adiponectin, visfatin and endothelin-1 were measured in 27 patients with severe IPAH and 30 healthy volunteers. RESULTS: Half of IPAH patients had osteoporosis...
February 2018: Kardiologiia
https://www.readbyqxmd.com/read/29466058/consensus-statement-by-the-american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-on-the-quality-of-dxa-scans-and-reports
#14
Angelo A Licata, Neil Binkley, Steven M Petak, Pauline M Camacho
OBJECTIVE: High-quality dual-energy X-ray absorptiometry (DXA) scans are necessary for accurate diagnosis of osteoporosis and monitoring of therapy; however, DXA scan reports may contain errors that cause confusion about diagnosis and treatment. This American Association of Clinical Endocrinologists/American College of Endocrinology consensus statement was generated to draw attention to many common technical problems affecting DXA report conclusions and provide guidance on how to address them to ensure that patients receive appropriate osteoporosis care...
February 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29466057/zoledronic-acid-versus-alendronate-in-the-treatment-of-children-with-osteogenesis-imperfecta-a-2-year-clinical-study
#15
Fang Lv, Yi Liu, Xiaojie Xu, Yuwen Song, Lujiao Li, Yan Jiang, Ou Wang, Weibo Xia, Xiaoping Xing
OBJECTIVE: Bisphosphonates have been demonstrated to increase the bone mineral density (BMD) of osteogenesis imperfecta (OI) patients. We aimed to compare the efficacy and safety of intravenous zoledronic acid and oral alendronate in patients with OI. METHODS: A total of 161 patients with OI ranging from 2 to 16 years old were included and randomized at a 2:1 ratio to receive either weekly oral alendronate (ALN) 70 mg or a once-yearly infusion of zoledronic acid (ZOL) for 2 years...
February 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29465475/physical-activity-and-bone-accretion-isotemporal-modeling-and-genetic-interactions
#16
Jonathan A Mitchell, Alessandra Chesi, Shana E McCormack, Diana L Cousminer, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Andrea Kelly, Struan F A Grant, Babette S Zemel
PURPOSE: To determine if replacing time spent in high and low impact physical activity (PA) predicts changes in pediatric bone mineral density (BMD) and content (BMC). METHODS: We analyzed data from the longitudinal Bone Mineral Density in Childhood Study (N=2,337 with up to 7 visits). The participants were aged 5-19 years at baseline, 51.2% were female and 80.6% were non-Black. Spine, total hip, and femoral neck areal BMD (aBMD) and total body less head (TBLH) BMC Z-scores were calculated...
February 20, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29464371/risk-factor-analysis-for-re-collapse-of-cemented-vertebrae-after-percutaneous-vertebroplasty-pvp-or-percutaneous-kyphoplasty-pkp
#17
Yong-Xian Li, Dan-Qing Guo, Shun-Cong Zhang, De Liang, Kai Yuan, Guo-Ye Mo, Da-Xing Li, Hui-Zhi Guo, Yongchao Tang, Pei-Jie Luo
PURPOSE: Re-collapse of cemented vertebrae occasionally occurs after percutaneous augmentation. However, the potential risks still remain unclear. Several articles have reported some possible risk factors which were not consistent or comprehensive. This study aimed to make a retrospective review on patients with osteoporotic vertebral compression fracture (OVCF) after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) and to further analyse the risk factors for treated vertebral refracture...
February 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29464357/decreased-bone-mineral-density-in-women-with-sheehan-s-syndrome-and-improvement-following-oestrogen-replacement-and-nutritional-supplementation
#18
Purnima Agarwal, Ramesh Gomez, Eesh Bhatia, Subhash Yadav
Sheehan's syndrome (SS) is an important cause of pan-hypopituitarism in women. There is scanty information on bone mineral density (BMD) in this condition. We determined BMD and the changes in BMD after oestrogen (E2) replacement and nutritional supplementation in women with SS. In a cross-sectional study, BMD was measured by DEXA in 83 patients [age (mean ± SD) 42 ± 9.2 years] and compared with an equal number of matched controls. In a sub-set of 19 patients, we conducted an open-label, prospective study to determine changes in BMD after 1 year of replacement of E2, and calcium and vitamin D3 supplementation...
February 20, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29463015/association-between-bone-mineral-density-of-femoral-neck-and-geriatric-nutritional-risk-index-in-rheumatoid-arthritis-patients-treated-with-biological-disease-modifying-anti-rheumatic-drugs
#19
Hiroto Tokumoto, Hiroyuki Tominaga, Yoshiya Arishima, Go Jokoji, Masaki Akimoto, Hideo Ohtsubo, Eiji Taketomi, Nobuhiko Sunahara, Satoshi Nagano, Yasuhiro Ishidou, Setsuro Komiya, Takao Setoguchi
Treatment of rheumatoid arthritis (RA) with biological disease-modifying anti-rheumatic drugs (bDMARDs) induces rapid remission. However, osteoporosis and its management remains a problem. The Geriatric Nutritional Risk Index (GNRI) evaluates the risk of malnutrition-related complications in elderly patients and has been shown to be a significant predictor of many diseases. We evaluated the correlation between GNRI and RA activity. In addition, risk factors for femoral neck bone loss were evaluated in RA patients treated with bDMARDs...
February 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29462094/effects-of-abaloparatide-on-bone-mineral-density-and-risk-of-fracture-in-postmenopausal-women-aged-80-years-or-older-with-osteoporosis
#20
Michael R McClung, Nicholas C Harvey, Lorraine A Fitzpatrick, Paul D Miller, Gary Hattersley, Yamei Wang, Felicia Cosman
OBJECTIVE: Advanced age is an important risk factor for fracture. The Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) trial showed that subcutaneous abaloparatide increased bone mineral density (BMD) and reduced the risk of vertebral and nonvertebral fractures in postmenopausal women with osteoporosis. This study describes the effects of abaloparatide in the subgroup of women aged 80 or more years in ACTIVE. METHODS: Post hoc analyses of BMD and fracture incidence in this subgroup of women who received abaloparatide or placebo in the 18-month, phase 3, double-blind, randomized controlled ACTIVE trial...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
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