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https://www.readbyqxmd.com/read/28328853/updated-association-of-tea-consumption-and-bone-mineral-density-a-meta-analysis
#1
Zhao-Fei Zhang, Jun-Long Yang, Huan-Chang Jiang, Zheng Lai, Feng Wu, Zhi-Xiang Liu
BACKGROUND: Current studies evaluating the association of tea consumption and bone mineral density (BMD) have yielded inconsistent findings. Therefore, we conducted a meta-analysis to assess the relationship between tea consumption and BMD. METHODS: The PubMed, Embase, and Cochrane Library databases were comprehensively searched, and a meta-analysis performed of all observational studies assessing the association of tea consumption and BMD. Forest plots were used to illustrate the results graphically...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327171/the-association-of-time-and-medications-with-changes-in-bone-mineral-density-in-the-2%C3%A2-years-after-critical-illness
#2
Neil R Orford, Michael Bailey, Rinaldo Bellomo, Julie A Pasco, Claire Cattigan, Tania Elderkin, Sharon L Brennan-Olsen, David J Cooper, Mark A Kotowicz
BACKGROUND: Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and time remain unexplored. The objective of this study was to describe the association of time after ICU admission, and post-ICU administration of bone anti-fracture therapy or glucocorticoids after critical illness, with change in BMD. METHODS: In this prospective observational study, conducted in a tertiary hospital ICU, we studied adult patients requiring mechanical ventilation for at least 24 hours and measured BMD annually for 2 years after ICU discharge...
March 21, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28326606/physical-activity-sedentary-time-and-bone-strength-from-childhood-to-early-adulthood-a-mixed-longitudinal-hr-pqct-study
#3
Leigh Gabel, Heather M Macdonald, Lindsay Nettlefold, Heather A McKay
Bone strength is influenced by bone geometry, density, and bone microarchitecture, which adapt to increased mechanical loads during growth. Physical activity (PA) is essential for optimal bone strength accrual; however, less is known about how sedentary time influences bone strength and its determinants. Thus, our aim was to investigate the prospective associations between PA, sedentary time, and bone strength and its determinants during adolescence. We used HR-pQCT at distal tibia (8% site) and radius (7% site) in 173 girls and 136 boys (aged 9 to 20 years at baseline)...
March 22, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28326353/in-vitro-osteogenic-capacity-of-bone-marrow-mscs-from-postmenopausal-women-reflect-the-osseointegration-of-their-cementless-hip-stems
#4
Jessica J Alm, Niko Moritz, Hannu T Aro
Age-related dysfunction of mesenchymal stromal cells (MSCs) is suggested as a main cause of altered bone repair with aging. We recently showed that in postmenopausal women undergoing cementless total hip arthroplasty (THA) aging, low bone mineral density (BMD) and age-related geometric changes of the proximal femur are risk factors for increased early migration and delayed osseointegration of the femoral stems. Extending these analyses, we have here explored how the in vitro osteogenic capacity of bone marrow MSCs from these patients reflects implant osseointegration, representing the patient's in vivo bone healing capacity...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28326352/aging-lifestyle-factors-hormones-and-bone-health-in-singaporean-men
#5
Victor Hng Hang Goh, William George Hart
PURPOSE: The present study examined how age, bodyweight, body fat, regular exercise and some endocrine factors are associated with osteoporosis, spine bone mineral density (Sbmd) and femoral neck bone mineral density (Fnbmd) in Singaporean men. METHODS: Body composition and bone scans of lumbar spine at L2-L4 and hip were carried out with duel-energy X-ray absorptiometry (DXA). Anthropometric parameters were measured and demographic data, medical history and exercise schedule were collected via a questionnaire...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28326339/glucose-dependent-insulinotropic-polypeptide-gip-and-gip-receptor-gipr-genes-an-association-analysis-of-polymorphisms-and-bone-in-young-and-elderly-women
#6
Gaurav Garg, Fiona E McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, Kristina Akesson
INTRODUCTION: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. METHODS: Association between GIP (rs2291725) and GIPR (rs10423928) and BMD, bone mineral content (BMC), bone microarchitecture, fracture and body composition was analyzed in the OPRA (75y, n = 1044) and PEAK-25 (25y; n = 1061) cohorts and serum-GIP in OPRA...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28326338/predictors-of-teriparatide-treatment-failure-in-patients-with-low-bone-mass
#7
Tarig Elraiyah, Adil H Ahmed, Zhen Wang, Joshua N Farr, Mohammad H Murad, Matthew T Drake
INTRODUCTION: While teriparatide is the only skeletal anabolic agent approved in the United States, treatment failure is a major concern which complicates its clinical utility. We sought to identify factors that predict response failure in patients with low bone mass. METHOD: We performed a retrospective study of adults with osteopenia or osteoporosis (T-scores < - 1.0 and - 2.5 SD below normal, respectively, at the total hip or lumbar spine) treated with teriparatide at the Mayo Clinic (Rochester, Minnesota) between November 2002-December 2012...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28326299/the-association-between-dehydroepiandrosterone-sulfate-dhea-s-and-bone-mineral-density-in-korean-men-and-women
#8
Seung-Gun Park, Sena Hwang, Jong-Suk Kim, Kyung-Chae Park, Yuri Kwon, Kyong-Chol Kim
BACKGROUND: The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In this study, we investigated the relationship between serum DHEA-S and BMD in both men and women. METHODS: This cross-sectional study evaluated a total of 294 healthy Korean participants through a medical examination program. And a subgroup of 154 participants was subjected to a longitudinal analysis...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28324752/vertical-ground-reaction-force-during-standing-and-walking-are-they-related-to-bone-mineral-density-left-right-asymmetries
#9
Marina Brozgol, Mira Arbiv, Anat Mirelman, Talia Herman, Jeffrey M Hausdorff, Nachum Vaisman
Osteoporosis is a systemic skeletal disease that is characterized by reduced bone mass, deterioration of bone tissue and skeletal fragility. The purpose of the current study was to determine whether asymmetrical femur bone mineral density (BMD) is associated with asymmetrical gait and standing. We compared measures of gait and standing asymmetry in subjects with (n=38) and without (n=11) significant left-right differences in BMD. Participants walked for 72m at their comfortable speed and stood quietly for 60s while outfitted with pressure-sensitive insoles...
March 7, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28324131/case-report-fast-reversal-of-severe-osteoporosis-after-correction-of-excessive-levothyroxine-treatment-and-long-term-follow-up
#10
C M Laine, K Landin-Wilhelmsen
This case report describes a 38-year-old woman, who presented with bilateral femoral stress fractures and osteoporosis after years of excessive levothyroxine treatment. Her bone health was restored rapidly and long-lasting with the reduction of levothyroxine dosage. No bone-active treatment was warranted. INTRODUCTION: Hyperthyroidism is a known risk factor for osteoporosis and fractures. Recent studies on patients with serum thyrotropin-suppressive therapy have not, however, indicated adverse effects on bone during long-term follow-up...
March 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28324062/gene-hormone-therapy-interaction-and-fracture-risk-in-postmenopausal-women
#11
Youjin Wang, Jean Wactawski-Wende, Lara E Sucheston-Campbell, Leah Preus, Kathleen M Hovey, Jing Nie, Rebecca D Jackson, Samuel K Handelman, Rami Nassir, Carolyn J Crandall, Heather M Ochs-Balcom
Context: Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored. Objective: The objective was to test an interaction between genetic susceptibility and HT on fracture risk. Design: We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated variants (Fx-GRS) and 50 bone mineral density (BMD) variants (BMD-GRS)...
March 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28324004/bone-turnover-is-suppressed-in-insulin-resistance-independent-of-adiposity
#12
K T Tonks, C P White, J R Center, D Samocha-Bonet, J R Greenfield
Context: The contribution of insulin resistance vs. adiposity to bone mineral density (BMD), bone turnover and fractures in humans remains unclear. Objective: Evaluate BMD and bone turnover markers (BTM) in lean (n=18) and overweight/obese individuals with (n=17) and without type 2 diabetes (n=34, deemed insulin-sensitive [Obsensitive, n=15] or insulin-resistant [Obresistant, n=19] by HOMA-IR). Design: Observational study. Outcome measures: Insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp; whole body BMD and fat mass (FM) by DXA; and BTM (osteocalcin [OC], procollagen type-1 propeptide [P1NP] and collagen type-1 cross-linked C-telopeptide [CTx]) fasting and during clamp hyperinsulinemia...
January 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323913/accrual-of-bone-mass-in-children-and-adolescents-with-cystic-fibrosis
#13
Sonakshi Sharma, Mirjana Jaksic, Sheryl Fenwick, Catherine Byrnes, Tim Cundy
Context: Low bone density is a recognised complication of cystic fibrosis (CF). Hypothesis: Accrual of bone mass is most impaired in the sickest children, as judged by nutritional status and pulmonary function. Design: Retrospective analysis of correlation between lumbar spine BMD, BMI and FEV1 z-score in children and adolescents with CF. Setting: Specialist CF service at a pediatric hospital. Patients: 60 participants aged 5...
February 22, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323146/hypogonadal-men-with-type-2-diabetes-mellitus-have-smaller-bone-size-and-lower-bone-turnover
#14
Georgia Colleluori, Lina Aguirre, Richard Dorin, David Robbins, Dean Blevins, Yoann Barnouin, Rui Chen, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal
INTRODUCTION: Both hypogonadism and type 2 diabetes mellitus (T2D) are associated with increased fracture risk. Emerging data support the negative effect of low testosterone on glucose metabolism, however, there is little information on the bone health of hypogonadal men with diabetes. We evaluated the bone mineral density (BMD), bone geometry and bone turnover of hypogonadal men with T2D compared to hypogonadal men without diabetes. MATERIALS AND METHODS: Cross-sectional study, men 40-74years old, with average morning testosterone (done twice) of<300ng/dl...
March 16, 2017: Bone
https://www.readbyqxmd.com/read/28321531/bone-quality-in-beta-thalassemia-intermedia-relationships-with-bone-quantity-and-endocrine-and-hematologic-variables
#15
Marina Baldini, A Marcon, F M Ulivieri, S Seghezzi, R Cassin, C Messina, M D Cappellini, G Graziadei
We report the first evaluation of bone quality in 70 thalassemia intermedia (TI) patients (37 males, 33 females, age 41 ± 12 years). Thirty-three patients (47%) had been transfused, 34 (49%) had been splenectomized, 39 (56%) were on iron chelation therapy, and 11 (16%) were on hydroxyurea. Mean hemoglobin was 9.2 ± 1.5 g/dl, median ferritin 537 ng/dl (range 14-4893), and mean liver iron concentration 7.6 ± 6.4 mg Fe/g dw. Fifteen patients (21%) had endocrinopathies, and 29 (41%) had vitamin D deficiency...
March 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28321507/the-relationship-between-cumulative-lifetime-ultraviolet-radiation-exposure-bone-mineral-density-falls-risk-and-fractures-in-older-adults
#16
M J W Thompson, D A Aitken, P Otahal, J Cicolini, T M Winzenberg, G Jones
Data linking cumulative lifetime vitamin D status with skeletal outcomes are lacking. We show that increasing cumulative sun exposure was associated with higher bone mineral density in younger males and protective against fractures in females independent of current vitamin D. This supports the concept that cumulative sun exposure is an important contributor to skeletal health. INTRODUCTION: While low 25-hydroxyvitamin D levels are associated with increased fracture risk, this reflects only recent sun exposure...
March 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28321061/effects-of-denosumab-on-bone-metabolic-markers-and-bone-mineral-density-in-patients-treated-with-glucocorticoids
#17
Masato Sawamura, Atsushi Komatsuda, Masaru Togashi, Hideki Wakui, Naoto Takahashi
Objective We performed a prospective study to determine the efficacy and safety of denosumab on bone metabolic indices and bone mineral density (BMD) in 29 patients receiving long-term glucocorticoids (GCs) who had clinical risk factors for fracture. Methods Among these patients, 16 had systemic lupus erythematosus (SLE), 6 RA, 4 other autoimmune diseases, and 3 renal diseases. All patients received donosumab 60 mg at baseline and 6 months. Serum N-terminal cross-linked telopeptide of type I collagen (NTX) and bone-specific alkaline phosphatase (BAP) levels were measured as bone metabolic indices...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28319943/femoral-neck-x-ray-absorptiometry-parameters-and-peripheral-quantitative-computer-tomography-tibial-cortical-density-predict-survival-in-dialysis-patients
#18
Natalie Yap, Phillip Wong, Stella McGinn, Maria-Liza Nery, Jean Doyle, Lynda Wells, Phillip Clifton-Bligh, Roderick J Clifton-Bligh
BACKGROUND: Low bone mineral density (BMD) is a known independent predictor of mortality in the general elderly population. However, studies in patients with end-stage renal disease (ESRD) are limited. The present study evaluated mortality during long-term follow-up in a population of patients having dialysis for ESRD, in whom BMD was also measured. METHODS: Fifty-eight patients with ESRD were recruited consecutively from a dialysis clinic and followed prospectively for 6 years...
March 21, 2017: Nephron
https://www.readbyqxmd.com/read/28319607/reduced-bone-mineral-density-in-children-with-screening-detected-celiac-disease
#19
Sara Björck, Charlotte Brundin, Magnus Karlsson, Daniel Agardh
OBJECTIVES: To assess if bone mass and metabolism are impaired in genetically at risk children with screening-detected celiac disease. METHODS: Included were 71 children with screening-detected celiac disease diagnosed at 10.0 ± 0.7 (mean ± SD) years and 142 matched controls as well as 30 children with screening-detected celiac disease diagnosed at 3.3 ± 0.4 years of age presently on a gluten-free diet for 6.9 ± 1.1 years and 60 matched controls...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28318867/efficacy-of-alendronate-for-the-prevention-of-bone-loss-in-calcar-region-following-total-hip-arthroplasty
#20
Yohei Yukizawa, Yutaka Inaba, Naomi Kobayashi, Hyonmin Choe, So Kubota, Tomoyuki Saito
BACKGROUND: Bone mineral density (BMD) loss around femoral implants, particularly in the proximal femur, is a common outcome after total hip arthroplasty. Previous studies reported the prevention of postsurgical decrease in BMD with the use of osteoporosis drug therapy. This randomized study evaluated the efficacy of alendronate and alfacalcidol for preserving BMD over a long-term follow-up. METHODS: Sixty consecutive patients with hip osteoarthritis who had undergone primary cementless total hip arthroplasty were randomly assigned to an alendronate (n = 20), alfacalcidol (n = 18), or control (n = 22) group...
February 27, 2017: Journal of Arthroplasty
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