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https://www.readbyqxmd.com/read/29665846/correlation-of-serum-levels-of-fibroblast-growth-factor-23-and-klotho-protein-levels-with-bone-mineral-density-in-maintenance-hemodialysis-patients
#1
Shubei Zheng, Yan Chen, Yu Zheng, Zhihong Zhou, Zhanyuan Li
OBJECTIVE: The correlation of serum fibroblast growth factor 23 (FGF-23) and Klotho protein levels with bone mineral density (BMD) in maintenance hemodialysis (MHD) patients was analyzed. METHODS: Between January 2015 and November 2015, 125 MHD patients in our hospital were enrolled. Dual-energy X-ray absorptiometry was used to examine the BMD in the femoral neck and lumbar spine of MHD patients. The patients were divided into three groups: a normal bone mass group, an osteopenia group, and an osteoporosis group...
April 17, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29665087/25-hydroxyvitamin-d-threshold-for-the-effects-of-vitamin-d-supplements-on-bone-density-secondary-analysis-of-a-randomized-controlled-trial
#2
Helen M Macdonald, Ian R Reid, Gregory D Gamble, William D Fraser, Jonathan C Tang, Adrian D Wood
Most trials of vitamin D supplementation have shown no benefits on bone density (BMD), though severe vitamin D deficiency causes osteomalacia which is associated with profound BMD deficits. Recently, the ViDA-BMD study from New Zealand demonstrated a threshold of baseline 25-hydroxyvitamin D (30 nmol/L) below which vitamin D supplementation did benefit BMD. We have now re-examined data from a similar trial in Aberdeen to determine whether a baseline 25-hydroxyvitamin D threshold of 30 nmol/L is also observed in that database...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29665068/osteoporosis-and-hip-fracture-risk-from-routine-computed-tomography-scans-the-fracture-osteoporosis-and-ct-utilization-study-focus
#3
Annette L Adams, Heidi Fischer, David L Kopperdahl, David C Lee, Dennis M Black, Mary L Bouxsein, Shireen Fatemi, Sundeep Khosla, Eric S Orwoll, Ethel S Siris, Tony M Keaveny
Methods now exist for analyzing previously taken clinical computed tomography (CT) scans to measure a dual-energy X-ray absorptiometry (DXA)-equivalent bone mineral density (BMD) at the hip and a finite element analysis-derived femoral strength. We assessed the efficacy of this "biomechanical CT" (BCT) approach for identifying patients at high risk of incident hip fracture in a large clinical setting. Using a case-cohort design sampled from 111,694 women and men aged 65 or older who had a prior hip CT scan, a DXA within 3 years of the CT, and no prior hip fracture, we compared those with subsequent hip fracture (n = 1959) with randomly selected sex-stratified controls (n = 1979) and analyzed their CT scans blinded to all other data...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29663382/effects-of-interleukin-7-interleukin-7-receptor-on-rankl-mediated-osteoclast-differentiation-and-ovariectomy-induced-bone-loss-by-regulating-c-fos-c-jun-pathway
#4
Ji-Jun Zhao, Zhao-Feng Wu, Ying-Hao Yu, Ling Wang, Li Cheng
To explore the effects of IL-7/IL-7R on the RANKL-mediated osteoclast differentiation in vitro and OVX-induced bone loss in vivo. BMMs and RAW264.7 were transfected with IL-7, IL-7R siRNA, c-Fos siRNA, and c-jun siRNA and later stimulated by RANKL. TRAP and toluidine blue staining were used to observe osteoclast formation and bone resorption, respectively. HE and TRAP staining were used to detect trabecular bone microstructure and osteoclasts of mice, respectively. qRT-PCR and Western blot analysis were used to examine expression...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663307/genome-wide-association-study-of-lncrna-polymorphisms-with-bone-mineral-density
#5
Qin Zeng, Ke-Hao Wu, Kun Liu, Yuan Hu, Xiang-Ding Chen, Lei Zhang, Hui Shen, Qin Tian, Lan-Juan Zhao, Hong-Wen Deng, Li-Jun Tan
Recent studies suggested that long noncoding RNAs (lncRNAs) were widely transcribed in the genome, but their potential roles in the genetic complexity of human disorders required further exploration. The purpose of the present study was to explore genetic polymorphisms of lncRNAs associated with bone mineral density (BMD) and its potential value. Based on the lncRNASNP database, 55,906 lncSNPs were selected to conduct a genome-wide association study meta-analysis among 11,140 individuals of seven independent studies for BMDs at femoral neck (FN), lumbar spine, and total hip (HIP)...
April 16, 2018: Annals of Human Genetics
https://www.readbyqxmd.com/read/29662781/the-effect-of-chinese-martial-arts-tai-chi-chuan-on-prevention-of-osteoporosis-a-systematic-review
#6
REVIEW
Tsz Ho Chow, Bo Yee Lee, Adrian Bing Fung Ang, Veronica Yi Ki Cheung, Michelle Man Ching Ho, Saori Takemura
Background/Objective: Tai Chi Chuan (TCC) is suggested to have beneficial effects on the musculoskeletal system. The aim of this systematic review is to evaluate the evidence of the effect of TCC on bone mineral density (BMD) and its potential for prevention of osteoporosis. Methods: A literature search was conducted using PubMed, Embase, and Cochrane databases from inception to January 2017. Randomized controlled studies, case-control trials, prospective cohort studies, and cross-sectional studies which evaluated the effect of TCC on BMD were selected without any subject or language restriction...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662773/characteristics-of-bone-biochemical-indices-in-predicting-secondary-osteoporotic-fracture-after-intertrochanteric-fracture-in-elderly-women
#7
Shaofeng Yang, Yanan Liu, Qin Shi, Jun Zou, Huilin Yang
Background: This study aimed to explore the characteristics of bone biochemical indices, including bone mineral density (BMD), metabolic markers in elderly women with osteoporotic intertrochanteric fracture and their relevance in secondary fracture. Methods: The standard for follow-up from 58 elderly women was established to analyse the BMD in the injured hip, healthy hip, and the vertebra at 1 week and 12 months after fracture. The serum levels of total procollagen type N-terminal propeptide (tPINP) and the age-related type I cross linked C-telopeptide (β-CTX) were recorded and compared between those patients with and without secondary fractures within 12 months...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662314/pretreatment-of-daily-teriparatide-enhances-the-increase-of-bone-mineral-density-in-cortical-bones-by-denosumab-therapy
#8
Mikio Kamimura, Akira Taguchi, Yukio Nakamura, Hidefumi Koiwai, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
Background: While it is well known that teriparatide (TPTD) increases bone mineral density (BMD) in osteoporotic patients, it is unknown whether TPTD pretreatment affects BMD after denosumab (DMAb) therapy. Methods: Fifty-seven patients in TPTD-pretreated group and 35 patients in DMAb-alone group had been further analyzed, all of whom were treated by DMAb for 1.5 years. Vitamin D (400 IU) and Ca (600 mg) supplementation was used in all patients. The BMD of lumbar 1-4 vertebrae (L-BMD), bilateral total hips (H-BMD), and bilateral femoral neck (FN-BMD) was quantified at first visit, and at 4, 8, 12, and 18 months after daily TPTD treatment following four times DMAb treatment...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29662267/decrement-in-bone-mineral-density-after-parathyroidectomy-in-a-pediatric-patient-with-primary-hyperparathyroidism
#9
Hidechika Morimoto, Hisakazu Nakajima, Jun Mori, Shota Fukuhara, Keiichi Shigehara, Shinsuke Adachi, Hajime Hosoi
Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Here, we report a case of a 13-yr-old boy with PHT who was referred to our institution for evaluation of hypercalcemia and hyperparathyroidism. Radiological investigation revealed an ectopic parathyroid adenoma below the right thyroid lobe...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29661688/effect-of-positioning-of-the-roi-on-bmd-of-the-forearm-and-its-subregions
#10
Elizabeth O Rosen, Elizabeth A McNamara, LaTarsha G Whittaker, Alan O Malabanan, Harold N Rosen
Inconsistent positioning of patients and region of interest (ROI) is known to influence the precision of bone mineral density (BMD) measurements in the spine and hip. However, it is unknown whether minor shifts in the positioning of the ROI along the shaft of the radius affect the measurement of forearm BMD and its subregions. The ultradistal (UD-), mid-, one-third, and total radius BMDs of 50 consecutive clinical densitometry patients were acquired. At baseline the distal end of the ROI was placed at the tip of the ulnar styloid as usual, and then the forearm was reanalyzed 10 more times, each time shifting the ROI 1 mm proximally...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29661687/impact-of-weight-loss-with-intragastric-balloon-on-bone-density-and-microstructure-in-obese-adults
#11
Eduardo Madeira, Miguel Madeira, Erika Paniago Guedes, Thiago Thomaz Mafort, Rodrigo Oliveira Moreira, Laura Maria Carvalho de Mendonça, Inayá Correa Barbosa Lima, Leonardo Vieira Neto, Paulo Roberto Alves de Pinho, Agnaldo José Lopes, Maria Lucia Fleiuss Farias
The historical concept that obesity protects against bone fractures has been questioned. Weight loss appears to reduce bone mineral density (BMD); however, the results in young adults are inconsistent, and data on the effects of weight loss on bone microstructure are limited. This study aimed to evaluate the impact of weight loss using an intragastric balloon (IGB) on bone density and microstructure. Forty obese patients with metabolic syndrome (mean age 35.1 ± 7.3 yr) used an IGB continuously for 6 mo...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29661041/prospective-risk-of-osteoporotic-fractures-in-patients-with-advanced-chronic-obstructive-pulmonary-disease
#12
Ayushman Gupta, Neil J Greening, Rachael A Evans, Abigail Samuels, Nicole Toms, Michael C Steiner
Despite the high prevalence of osteoporosis in chronic obstructive pulmonary disease (COPD) patients, the fracture risk prediction tools are not routinely undertaken in the management of COPD. We quantified fracture risk using a validated risk prediction tool (Fracture Risk Assessment (FRAX®)) and determined potential bone-protection treatment needs in patients with advanced COPD. The 10-year probability of major osteoporotic or hip fracture was calculated using the FRAX tool in a cohort of patients attending a hospital complex COPD service...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29660685/evidence-of-wnt-%C3%AE-catenin-alterations-in-brain-and-bone-of-a-tauopathy-mouse-model-of-alzheimer-s-disease
#13
Christine M Dengler-Crish, Hope C Ball, Li Lin, Kimberly M Novak, Lisa Noelle Cooper
Low bone mineral density (BMD) is a significant comorbidity in Alzheimer's disease (AD) and may reflect systemic regulatory pathway dysfunction. Low BMD has been identified in several AD mouse models selective for amyloid-β or tau pathology, but these deficits were attributed to diverse mechanisms. In this study, we identified common pathophysiological mechanisms accounting for bone loss and neurodegeneration in the htau mouse, a tauopathy model with an early low BMD phenotype. We investigated the Wnt/β-catenin pathway-a cellular signaling cascade linked to both bone loss and neuropathology...
March 23, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29659886/bone-parameters-in-anorexia-nervosa-and-athletic-amenorrhea-comparison-of-two-hypothalamic-amenorrhea-states
#14
Nurgun Kandemir, Meghan Slattery, Kathryn E Ackerman, Shreya Tulsiani, Amita Bose, Vibha Singhal, Charumathi Baskaran, Seda Ebrahimi, Mark Goldstein, Kamryn Eddy, Anne Klibanski, Madhusmita Misra
Purpose: We have reported low bone mineral density (BMD), impaired bone structure, and increased fracture risk in anorexia nervosa (AN) and normal-weight, oligo-amenorrheic athletes (OA). However, data directly comparing compartment-specific bone parameters in AN, OA and controls are lacking. Methods: 426 females 14-21.9 years old were included; 231 AN, 94 OA and 101 normal-weight eumenorrheic controls. Dual energy x-ray absorptiometry was used to assess areal BMD (aBMD) of the whole body less head (WBLH), spine, and hip...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29658832/the-associations-between-hypovitaminosis-d-higher-pth-levels-with-bone-mineral-densities-and-risk-of-the-10-year-probability-of-major-osteoporotic-fractures-in-chinese-patients-with-t2dm
#15
Xiao-Feng Wang, Jing-Jia Yu, Xiao-Jing Wang, Yi-Xuan Jing, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning, Jian-Min Liu, Hong-Yan Zhao
OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D (25(OH)D) and intact PTH were also quantified...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29658659/-effect-of-resveratrol-on-peak-bone-mass-in-growing-rats
#16
Huirong Xi, Yuhai Gao, Fangfang Yang, Wenyuan Li, Huiping Ma, Keming Chen
<b>Objective:</b> To investigate the effect of resveratrol on peak bone mineral density and bone mass in growing rats. <b>Methods:</b> Thirty-six female healthy Wistar rats were randomly divided into control group, icariin group and resveratrol group with 12 rats in each group. Icariin (25 mg·kg<sup>-1</sup>·d<sup>-1</sup>), resveratrol (8.4 mg·kg<sup>-1</sup>·d<sup>-1</sup>) or equal volume of distilled water were given by gavage to icariin group, resveratrol group and control group, respectively...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29658534/the-influence-of-osteoporotic-bone-structures-of-the-pelvic-hip-complex-on-stress-distribution-under-impact-load
#17
Katarzyna Arkusz, Tomasz Klekiel, Niezgoda Niezgoda, Romuald Będziński
PURPOSE: The aim of this study was to determine the effect of bone mineral density (BMD) on the stress distribution in pelvic-hip complex (PHC) model which included bone structures and soft tissues. Bone mass changes in osteoporosis and osteopenia were considered in this analysis. In addition, the relations between force direction and stress distribution causing PHC fractures were determined. METHODS: This paper presents the development and validation of a detailed 3D finite element model with high anatomical fidelity of the PHC and BMD changes in trabecular and cortical bones, modelled based on CT scans...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29657446/assessment-of-the-risk-of-low-bone-mineral-density-in-premenopausal-japanese-female-patients-with-systemic-lupus-erythematosus
#18
Yu Mori, Kazuyoshi Baba, Atsushi Kogure, Takuya Izumiyama, Michiharu Matsuda, Naoko Mori, Tomonori Ishii, Eiji Itoi
Background: The aim of this study was to assess the relationships between clinical parameters and bone mineral density (BMD) in Japanese female patients with systemic lupus erythematosus (SLE). Methods: A total of female 136 SLE patients without menopause were retrospectively assessed to identify associations between age, disease duration, body mass index (BMI), glucocorticoid usage and disease activity and BMD based on the treatment with or without bisphosphonate...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29657026/muscular-maximal-strength-indices-and-bone-variables-in-a-group-of-elderly-women
#19
Riad Nasr, Nathalie Al Rassy, Eric Watelain, Joseph Matta, Fabienne Frenn, Maroun Rizkallah, Ghassan Maalouf, César El Khoury, Abdel-Jalil Berro, Rawad El Hage
The aim of the present study was to explore the relations between muscular maximal strength indices and bone parameters (bone mineral density [BMD], hip geometry indices, and trabecular bone score [TBS]) in a group of elderly women. This study included 35 healthy elderly women whose ages range between 65 and 75 yr (68.1 ± 3.1 yr). BMD (in gram per square centimeter) was determined for each individual by dual-energy X-ray absorptiometry at the whole body, lumbar spine (L1-L4), total hip (TH), and femoral neck (FN)...
March 22, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29657025/physical-fitness-adiposity-and-diets-as-surrogate-measures-of-bone-health-in-schoolchildren-a-biochemical-and-cross-sectional-survey-analysis
#20
Ahmad H Alghadir, Sami A Gabr, Ashraf A Rizk
This study aimed to investigate the associations between adiposity, muscular fitness (MF), diet, sun exposure, and physical activity profiles as surrogate measures with bone health status in a sample of schoolchildren aged 8-18 yr old. A total of 250 Egyptian schoolchildren aged 8-18 yr were randomly invited to participate in these cross-sectional survey analyses. Calcaneal broadband ultrasound attenuation (c-BUA), bone mineral density (BMD), and bone formation markers (total calcium, serum bone alkaline phosphatase, and osteocalcin) were measured as markers of bone health...
March 21, 2018: Journal of Clinical Densitometry
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