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https://www.readbyqxmd.com/read/29040721/ratio-of-endogenous-secretory-receptor-for-advanced-glycation-end-products-to-pentosidine-predicts-fractures-in-men
#1
Junko Tamaki, Katsuyasu Kouda, Yuki Fujita, Masayuki Iki, Akiko Yura, Masakazu Miura, Yuho Sato, Nozomi Okamoto, Norio Kurumatani
Context: Although the endogenous secretory receptor for advanced glycation end products (esRAGE) has been associated with reduced activity of pentosidine (PEN), the association between PEN, esRAGE, and fracture is poorly understood. Objectives: To evaluate the ability of serum PEN and esRAGE levels to predict fragility fractures. Methods: A cohort of 1,285 Japanese men aged ≥65 years old participated in a 2007-2008 FORMEN Study baseline survey, as part of the Fujiwara-kyo prospective cohort study...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29035723/raloxifene-reduces-the-risk-of-local-alveolar-bone-destruction-in-a-mouse-model-of-periodontitis-combined-with-systemic-postmenopausal-osteoporosis
#2
Ryota Ichimaru, Tsukasa Tominari, Shosei Yoshinouchi, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Yukihiro Numabe, Gillian Murphy, Hideaki Nagase, Chisato Miyaura, Masaki Inada
OBJECTIVE: Periodontitis is characterized by local inflammation leading to tooth loss and severe destruction of alveolar bone. Raloxifene is a selective estrogen receptor modulator (SERM) that halts estrogen deficiency-induced systemic bone loss in postmenopausal osteoporosis without the side effects of cancer in breast and uterus. In this study, we examined the effects of raloxifene on alveolar bone mass in a mouse model with estrogen deficiency-induced periodontitis. METHODS: Periodontitis was induced by the injection of lipopolysaccharide (LPS) into the lower gingiva in ovariectomized (OVX) mice, and the alveolar bone and femur bone mineral density (BMD) were analyzed by dual-energy X-ray absorptiometry...
September 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29034571/association-between-subclinical-thyroid-dysfunction-and-change-in-bone-mineral-density-in-prospective-cohorts
#3
D Segna, D C Bauer, M Feller, C Schneider, H A Fink, C E Aubert, T-H Collet, B R da Costa, K Fischer, R P Peeters, A R Cappola, M R Blum, H A van Dorland, J Robbins, K Naylor, R Eastell, A G Uitterlinden, F Rivadeneira Ramirez, A Gogakos, J Gussekloo, G R Williams, A Schwartz, J A Cauley, D A Aujesky, H A Bischoff-Ferrari, N Rodondi
BACKGROUND: Subclinical hyperthyroidism (SHyper) has been associated with increased risk of hip and other fractures, but the linking mechanisms remain unclear. OBJECTIVE: To investigate the association between subclinical thyroid dysfunction and bone loss. METHODS: Individual participant data analysis was performed after a systematic literature search in MEDLINE/EMBASE (1946-2016). Two reviewers independently screened and selected prospective cohorts providing baseline thyroid status and serial bone mineral density (BMD) measurements...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29034241/bone-mineral-density-after-weight-gain-in-160-patients-with-anorexia-nervosa
#4
Najate Achamrah, Moïse Coëffier, Pierre Jésus, Jocelyne Charles, Agnès Rimbert, Pierre Déchelotte, Sébastien Grigioni
Low bone mineral density (BMD) is a frequent complication in anorexia nervosa (AN). There are controversial points of views regarding the restoration of bone mineralization after recovery in AN. We aimed to assess changes of BMD at 3 years in patients with AN and to explore the relationships between body composition, physical activity, and BMD. Patients with AN were included from 2009 to 2011 in a first visit (T0) with evaluation of weight, height, body mass index (BMI), body composition [fat mass (FM) and fat-free mass], and BMD...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29033393/new-bioactive-glass-scaffolds-with-exceptional-qualities-for-bone-tissue-regeneration-response-of-osteoblasts-and-osteoclasts
#5
Tia Kowal, Natalie C Hahn, Stephanie Eider, Jutta Marzillier, Daniella Marie Fodera, Ukrit Thamma, Himanshu Jain, Matthias M Falk
Tissue regeneration is a significantly improved alternative to tissue replacement by implants. It requires porous bioscaffolds for the restoration of natural tissue rather than relying on bio-inactive, often metallic implants. Recently, we developed technology for fabricating novel, nano-macroporous bioactive 'Tailored Amorphous Multi-Porous (TAMP)' hard tissue scaffolds using a 70 mol% SiO2-30 mol% CaO model composition. The TAMP silicate scaffolds, fabricated by a modified sol-gel process, have shown excellent biocompatibility via the rapid formation of hydroxyapatite in biological fluids as well as in early tests with bone forming cells...
October 16, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29032815/effects-of-rosiglitazone-on-the-outcome-of-experimental-periapical-lesions-in-mice
#6
Katharina Morant H de Oliveira, Gustavo P Garlet, Andiara De Rossi, Driely Barreiros, Alexandra M Queiroz, Lea Assed Bezerra da Silva, Paulo Nelson-Filho, Raquel Assed Bezerra da Silva
INTRODUCTION: The purpose of this study was to evaluate a protocol for systemic administration of rosiglitazone in mice in order to stimulate apoptosis of osteocytes in the jaws and to evaluate the effect of osteocyte apoptosis induced by rosiglitazone in the progression of periapical lesions in mice at 7, 21, and 42 days. METHODS: C57BL/6 mice at 4-5 weeks of age were used. In phase 1, mice (n = 24) were treated with rosiglitazone (gavage, 10 mg/kg dose) or without (phosphate-buffered saline + 10% dimethyl sulfoxide) for 1, 2, or 3 weeks...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29031689/oral-administration-of-kaempferol-inhibits-bone-loss-in-rat-model-of-ovariectomy-induced-osteopenia
#7
Beata Nowak, Agnieszka Matuszewska, Anna Nikodem, Jarosław Filipiak, Marcin Landwójtowicz, Ewa Sadanowicz, Diana Jędrzejuk, Marta Rzeszutko, Krzysztof Zduniak, Tomasz Piasecki, Przemysław Kowalski, Wojciech Dziewiszek, Anna Merwid-Ląd, Małgorzata Trocha, Tomasz Sozański, Joanna Kwiatkowska, Marek Bolanowski, Adam Szeląg
BACKGROUND: Postmenopausal osteoporosis and osteoporotic fractures constitute an increasing problem in developing countries. Kaempferol, isolated from seeds of Cuscuta chinensis, is an active flavonoid inhibiting in vitro osteoclast activity. The aim of the presented research was an assessment of kaempferol effect on estrogen-deficiency-induced bone structure disturbances in rats. METHODS: The study was performed on 24 Wistar female rats divided into 3 groups: SHAM - rats undergoing a "sham" surgery, OVX-C - control group of animals that underwent ovariectomy, OVX-K - rats undergoing ovariectomy and receiving kaempferol for 8 weeks (from day 56 to day 112)...
May 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29031686/oestrogen-receptor-%C3%AE-er%C3%AE-regulates-osteogenic-differentiation-of-human-dental-pulp-cells
#8
Aishah Alhodhodi, Hanaa Alkharobi, Matthew Humphries, Hasanain Alkhafaji, Reem El-Gendy, Georg Feichtinger, Valerie Speirs, James Beattie
Estradiol (E2) has many important actions in the tissues of the oral cavity. Disruption of E2 metabolism or alterations in systemic E2 concentrations have been associated with compromised periodontal health. In many instances such changes occur secondarily to the well characterised effects of E2 on bone physiology -especially maintenance of bone mineral density (BMD). Despite these important epidemiological findings, little is known about the mechanism of action of E2 in oral tissues or the expression and function of oestrogen receptor (ER) isoforms in these tissues...
October 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29030774/effects-of-growth-hormone-therapy-on-bone-density-and-fracture-risk-in-age-related-osteoporosis-in-the-absence-of-growth-hormone-deficiency-a-systematic-review-and-meta-analysis
#9
Maya Barake, Asma Arabi, Nancy Nakhoul, Ghada El-Hajj Fuleihan, Sarah El Ghandour, Anne Klibanski, Nicholas A Tritos
PURPOSE: In adults, growth hormone deficiency (GHD) has been associated with low bone mineral density (BMD), an effect counteracted by growth hormone (GH) replacement. Whether GH is beneficial in adults with age-related bone loss and without hypopituitarism is unclear. METHODS: We conducted a systematic literature search using Medline, Embase and the Cochrane Register of Controlled Trials. We extracted and analyzed data according to the bone outcome included [bone mineral content (BMC), BMD, and bone biomarker, fracture risk]...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29029190/pharmacokinetics-of-igf-i-in-papp-a2-deficient-patients-growth-response-and-effects-on-glucose-and-bone-density
#10
Catalina Cabrera-Salcedo, Tomoyuki Mizuno, Leah Tyzinski, Melissa Andrew, Alexander A Vinks, Jan Frystyk, Halley Wasserman, Catherine M Gordon, Vivian Hwa, Philippe Backeljauw, Andrew Dauber
Context: PAPP-A2 cleaves IGFBP-3 and -5 releasing free IGF-I. Homozygous mutations in PAPP-A2 result in growth failure with elevated total but low free IGF-I. Objective: To determine the 24-hour pharmacokinetic profile of free and total IGF-I after a dose of rhIGF-I. We describe the growth response and effects on glucose metabolism and bone mineral density (BMD) after one year of rhIGF-I therapy. Design and patients: Three affected siblings, their heterozygous parents, and two healthy controls participated...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028685/use-of-genetic-algorithm-combinational-single-nucleotide-polymorphisms-could-modify-the-association-of-blood-lead-levels-and-bone-matrix-density
#11
Chien-Juan Chen, Hsueh-Wei Chang, Cheng-Hong Yang, Hung-Yi Chuang, Hsin-Su Yu
BACKGROUND: Previous studies have not explored the relationship between a single gene and a single disease. Our study aims to investigate the association of multiple genotypes with blood lead levels and bone matrix density (BMD) by using genetic algorithms. METHODS: Our research focused on 506 employees (245 males and 261 females) of a lead battery factory in Taiwan. We collected data on their BMD, blood lead level, and 6 SNPs (ACE, alpha-adducin, Bsm, Tag, Apa, and ALAD); these factors were analyzed using discrete binary particle swarm optimization (DBPSO) and logistic regression analysis...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028271/influence-of-adipose-tissue-mass-on-bone-mass-in-an-overweight-or-obese-population-systematic-review-and-meta-analysis
#12
Eimear Dolan, Paul A Swinton, Craig Sale, Aoife Healy, John O'Reilly
The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations. The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations. Three databases were searched electronically. In addition, reference lists of relevant articles were screened. A total of 16 studies, comprising 2587 participants and 75 correlation coefficients were selected for inclusion in the review...
October 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29027045/characteristics-of-patients-with-fragility-hip-fractures-in-the-northern-kyushu-district-in-japan-a-multicenter-prospective-registry-based-on-an-electronic-data-capture-system
#13
Akiko Oyamada, Yoshihiro Matsumoto, Yoshifumi Wakata, Atsushi Kimura, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Hirokazu Shiraishi, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Riku Sakimura, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Shoji Tokunaga, Naoki Nakashima, Yukihide Iwamoto, Yasuharu Nakashima
Osteoporosis has become a worldwide public health problem, in part due to the fact that it increases the risk of fragility hip fractures (FHFs). The epidemiological assessment of FHFs is critical for their prevention; however, datasets for FHFs in Japan remain scarce. This was a multicenter, prospective, observational study in the northern district of Kyushu Island. Inclusion criteria were age > 60 years with a diagnosis of FHF and acquisition of clinical data by an electronic data capture system. Of 1294 registered patients, 1146 enrolled in the study...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29024249/bone-strength-in-girls-and-boys-following-a-distal-radius-fracture-a-2-year-hr-pqct-double-cohort-study
#14
Heather M Macdonald, Mikko Määttä, Leigh Gabel, Kishore Mulpuri, Heather A McKay
PURPOSE: We recently reported impaired bone strength in girls with low- to moderate-energy distal radius fractures (Fx) compared with girls with no history of forearm fractures (Non-Fx). We aimed to determine whether bone strength deficits observed at baseline were still present after two years. METHODS: We assessed bone strength, microarchitecture and BMD of the non-fractured (Fx) and non-dominant (Non-Fx) distal radius (7% site) at baseline, 12- and 24-months using high-resolution pQCT (Scanco Medical) in 104 girls (11...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29024045/association-between-dietary-fiber-intake-and-bone-loss-in-the-framingham-offspring-study
#15
Zhaoli Dai, Yuqing Zhang, Na Lu, David T Felson, Douglas P Kiel, Shivani Sahni
Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between genders. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts and legumes) and bone loss at the femoral neck, trochanter and lumbar spine (L2-4) in older men and women. In the Framingham Offspring Study, at baseline (1996-2001), diet was assessed using the Willett food frequency questionnaire and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023918/scrutinizing-the-genetic-underpinnings-of-bone-strength
#16
Fernando Rivadeneira, Andre G Uitterlinden
Every year osteoporosis causes millions of fractures worldwide, with the lifetime risk of suffering a wrist, hip or vertebral fracture estimated to be about 30% in developed countries [1]. Osteoporosis has been operationally defined for diagnostic and treatment purposes on the basis of the bone mineral density (BMD) assessment performed at the skeletal sites where fracture is most common. Nevertheless, BMD measurement alone is not optimal for the detection of individuals at high risk of fracture.
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29022646/low-skeletal-mass-is-an-important-predictor-of-osteoporosis-in-hiv-infected-men-in-india
#17
Deep Dutta, Meha Sharma, Rahul Bansal, Neera Sharma, Umesh Chandra Garga, Atul Anand, Kumar Gaurav
INTRODUCTION: This study evaluated prevalence and predictors of osteoporosis and sarcopenia in men with HIV. MATERIAL AND METHODS: 220 men with HIV were screened, of which 115 men, 30-50 years-age, having at least 1-year follow-up, underwent hormonal and DEXA analysis. 40 controls were also evaluated. RESULTS: Males with HIV had significantly lower BMD and Z-scores at all sites. Osteoporosis was diagnosed in 64.35%; commonest site being radius total (49...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29021920/vitamin-d-and-calcium-are-required-at-the-time-of-denosumab-administration-during-osteoporosis-treatment
#18
Yukio Nakamura, Takako Suzuki, Mikio Kamimura, Kohei Murakami, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group (18 cases) or a denosumab plus vitamin D supplementation group (combination group; 23 cases). We measured serum bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase (TRACP)-5b and urinary N-terminal telopeptide of type-I collagen (NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months...
2017: Bone Research
https://www.readbyqxmd.com/read/29020329/vitamin-d3-supplementation-increases-spine-bone-mineral-density-in-adolescents-and-young-adults-with-hiv-infection-being-treated-with-tenofovir-disoproxil-fumarate-a-randomized-placebo-controlled-trial
#19
Peter L Havens, Charles B Stephensen, Marta D Van Loan, Gertrud U Schuster, Leslie R Woodhouse, Patricia M Flynn, Catherine M Gordon, Cynthia G Pan, Brandy Rutledge, D Robert Harris, Georgine Price, Alyne Baker, William A Meyer, Craig M Wilson, Rohan Hazra, Bill G Kapogiannis, Kathleen Mulligan
Background: Tenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized vitamin D3 (VITD3) would increase BMD in youth receiving TDF. Methods: Randomized double-blind placebo-controlled trial of directly observed VITD3 vs. placebo every 4 weeks for 48 weeks in youth ages 16-24 years with HIV, viral load <200 copies/mL, taking TDF-containing combination antiretroviral therapy (TDF-cART) for ≥180 days. Participants (N=214) received a daily multivitamin containing VITD3 400 IU and calcium 162 mg, plus monthly randomized VITD3 50,000 IU (N=109) or placebo (N=105)...
August 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019883/bone-mineral-density-changes-of-lumbar-spine-and-femur-in-osteoporotic-patient-treated-with-bisphosphonates-and-beta-hydroxy-beta-methylbutyrate-hmb-case-report
#20
Marcin R Tatara, Witold Krupski, Barbara Majer-Dziedzic
RATIONALE: Currently available approaches to osteoporosis treatment include application of antiresorptive and anabolic agents influencing bone tissue metabolism. The aim of the study was to present bone mineral density (BMD) changes of lumbar spine in osteoporotic patient treated with bisphosphonates such as ibandronic acid and pamidronic acid, and beta-hydroxy-beta-methylbutyrate (HMB). PATIENT CONCERNS: BMD and volumetric BMD (vBMD) of lumbar spine were measured during the 6 year observation period with the use of dual-energy X-ray absorptiometry (DEXA) and quantitative computed tomography (QCT)...
October 2017: Medicine (Baltimore)
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