Yangqian Jiang, Yiqun Xu, Shuxin Xiao, Xianxian Zhu, Hong Lv, Lu Zang, Shuifang Lei, Xin Xu, Bo Xu, Xiumei Han, Jin Zhu, Jiangbo Du, Hongxia Ma, Zhibin Hu, Xiufeng Ling, Jiayin Dai, Yuan Lin
Phthalate exposure can adversely impact ovarian reserve, yet investigation on the influence of its alternative substance, the non-phthalate plasticizer diisononyl-cyclohexane-1,2-dicarboxylate (DINCH), on ovarian reserve is very sparce. We aimed to investigate the associations of phthalate and DINCH exposure as well as their combined mixture with ovarian reserve. This present study included 657 women seeking infertility care in Jiangsu, China (2015-2018). Urine samples during enrollment prior to infertility treatment were analyzed using high-performance liquid chromatography-isotope dilution tandem mass spectrometry (UPLC-MS/MS) to quantify 17 phthalate metabolites and 3 DINCH metabolites...
April 2, 2024: Science of the Total Environment