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https://www.readbyqxmd.com/read/27920851/zinner-syndrome-a-rare-developmental-anomaly-of-the-mesonephric-duct-diagnosed-on-magnetic-resonance-imaging
#1
Shibani Mehra, Rajeev Ranjan, Umesh Chandra Garga
Developmental anomalies of the urogenital tract are rare but often encountered. Zinner's syndrome is a rare congenital abnormality of mesonephric (Wolffian) duct consisting of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction due to developmental arrest in early embryogenesis affecting the caudal end of Mullerian duct and only approximately a 100 cases have been reported so far. Radiologic modalities such as intravenous pyelography, ultrasonography, vasovesiculography, contrast enhanced computed tomography, and magnetic resonance imaging are all helpful in diagnosis of this unusual entity...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920841/wolffian-origin-of-vagina-unfolds-the-embryopathogenesis-of-ohvira-obstructed-hemivagina-and-ipsilateral-renal-anomaly-syndrome-and-places-ohvira-as-a-female-counterpart-of-zinner-syndrome-in-males
#2
Yashant Aswani, Ravi Varma, Pradeep Choudhary, Reeta B Gupta
BACKGROUND: The classical theory of Müllerian origin of upper vagina fails to explain complex urogenital malformations like OHVIRA syndrome; the Acien's hypothesis, however, unravels the hidden embryopathogenesis. As per Acien, Wolffian (mesonephric) ducts instead of Müllerian ducts and sinovaginal bulbs, give rise to the vagina. The new hypothesis, however, retains the concept of origin of the ureters (with ureters inducing renal development) by the former and the uterus by Müllerian ducts...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27918066/anti-m%C3%A3-llerian-hormone-and-polycystic-ovary-syndrome
#3
Agnieszka Łebkowska, Irina Kowalska
Anti-Müllerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor β family, reflecting the number of ovarian antral follicles. Polycystic ovary syndrome (PCOS) is a common endocrinopathy predisposing to infertility, metabolic and cardiovascular complications. In our review, we discuss the role of AMH in PCOS pathophysiology and its clinical applications according to the published studies. Improvement of AMH assay validity will allow to widen the clinical utility of this valuable biomarker...
December 5, 2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27911779/retinoic-acid-signaling-determines-the-fate-of-uterine-stroma-in-the-mouse-m%C3%A3-llerian-duct
#4
Tadaaki Nakajima, Taisen Iguchi, Tomomi Sato
The Müllerian duct develops into the oviduct, uterus, and vagina, all of which are quite distinct in their morphology and function. The epithelial fate of these female reproductive organs in developing mice is determined by factors secreted from the stroma; however, how stromal differentiation occurs in the female reproductive organs derived from the Müllerian duct is still unclear. In the present study, roles of retinoic acid (RA) signaling in developing female reproductive tracts were investigated. Retinol dehydrogenase 10 (RDH10) and aldehyde dehydrogenase family 1 subfamily A2 (ALDH1A2) mRNAs and proteins and transactivation activity of endogenous RA were found in the stroma of proximal Müllerian ducts and gradually decreased from the proximal to caudal regions in fetal mice...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27910705/left-right-differences-in-ovarian-volume-and-antral-follicle-count-in-1423-women-of-reproductive-age
#5
Anne-Sofie Korsholm, Helene Westring Hvidman, Janne Gasseholm Bentzen, Anders Nyboe Andersen, Kathrine Birch Petersen
The aim of this cross-sectional study was to investigate side differences in antral follicle count (AFC) and ovarian volume in left versus right ovaries in relation to chronological and "biological" age, the latter estimated by anti-Müllerian hormone (AMH) levels. The cohort comprised 1423 women: 1014 fertile and 409 infertile. All were examined by transvaginal sonography and serum AMH. Overall the right ovary contained 8.1% more antral follicles (p = 0.002) and had 10.7% larger volume compared with the left (p < 0...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27907901/serum-amh-levels-in-healthy-women-from-brca1-2-mutated-families-are-they-reduced
#6
Theodora C van Tilborg, Inge A P Derks-Smeets, Anna M E Bos, Jan C Oosterwijk, Ron J van Golde, Christine E de Die-Smulders, Lizet E van der Kolk, Wendy A G van Zelst-Stams, Maria E Velthuizen, Annemieke Hoek, Marinus J C Eijkemans, Joop S E Laven, Margreet G E M Ausems, Frank J M Broekmans
STUDY QUESTION: Do BRCA1/2 mutation carriers have a compromised ovarian reserve compared to proven non-carriers, based on serum anti-Müllerian hormone (AMH) levels? SUMMARY ANSWER: BRCA1/2 mutation carriers do not show a lower serum AMH level in comparison to proven non-carriers, after adjustment for potential confounders. WHAT IS KNOWN ALREADY: It has been suggested that the BRCA genes play a role in the process of ovarian reserve depletion, although previous studies have shown inconsistent results regarding the association between serum AMH levels and BRCA mutation status...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27906711/polycystic-ovary-syndrome-in-adolescent-girls
#7
Natalie Hecht Baldauff, Selma Feldman Witchel
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder that appears to have its origins during the peripubertal years. The diagnostic conundrum is that the typical clinical features, irregular menses and acne, occur during normal female puberty. Understanding the physiologic origins and molecular basis of the dysregulated hypothalamic-pituitary-gonadal axis in PCOS is fundamental to interrupting the distinctive vicious cycle of hyperandrogenism and chronic anovulation...
November 30, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27906603/utility-of-ovarian-reserve-screening-with-anti-m%C3%A3-llerian-hormone-for-reproductive-age-women-deferring-pregnancy
#8
Lisa C Grossman, Lauren Zakarin Safier, Melissa D Kline, Cariann W Chan, Rogerio A Lobo, Mark V Sauer, Nataki C Douglas
BACKGROUND: Ovarian reserve (OR) testing with serum anti-Müllerian hormone (AMH) can provide information about a woman's fertility potential. The aim of this study was to assess interest and knowledge about OR testing and investigate the utility of measuring AMH in women of reproductive age deferring pregnancy. METHODS: Women ages 27-37 years currently delaying childbearing were invited to take a survey regarding attitudes and knowledge about OR testing before and after an AMH measurement with explanation of their results...
December 1, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27905042/preventive-salpingectomy-and-ovarian-reserve-experimental-study
#9
I A Petrov, O A Tikhonovskaya, A O Okorokov, I I Kupriyanova, M S Petrova, S V Logvinov
The levels of anti-Müllerian hormone, follicle-stimulating hormone, and testosterone were studied in rats after removal of the uterine horns, oviducts, or combined surgery. The effects of preventive salpingectomy on ovarian reserve were studied. After preventive salpingectomy, the level of anti-Müllerian hormone was low throughout the experiment, follicle-stimulating hormone increased only by the end of observation (on day 40), and testosterone level decreased only on day 10. Hysterectomy alone caused no changes in the concentrations of the studied hormones on day 10 after surgery...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27900396/-persistent-mullerian-duct-syndrome-rare-incidental-finding-during-treatment-of-pediatric-inguinal-hernia
#10
P Sperling, T Meyer
BACKGROUND: Persistent mullerian duct syndrome (PMDS) is a rare, autosomal recessive disorder. It is a form of male disorder of sexual differentiation in which mullerian duct structures are present in male phenotypes and 46XY karyotypes. In affected individuals, uterus, fallopian tubes, cervix and vagina are present. METHODS: A 2-month-old boy was admitted to hospital with a right-sided inguinal hernia. The physical examination showed a phenotypically normal boy with a right sided indirect inguinal hernia and impalpable testis...
November 29, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27899818/bnc2-is-a-putative-tumor-suppressor-gene-in-high-grade-serous-ovarian-carcinoma-and-impacts-cell-survival-after-oxidative-stress
#11
Laura Cesaratto, Eleonora Grisard, Michela Coan, Luigi Zandonà, Elena De Mattia, Elena Poletto, Erika Cecchin, Fabio Puglisi, Vincenzo Canzonieri, Maria Teresa Mucignat, Antonella Zucchetto, Gabriele Stocco, Alfonso Colombatti, Milena S Nicoloso, Riccardo Spizzo
Rs3814113 is the single-nucleotide polymorphism (SNP) showing the strongest association with high-grade serous ovarian carcinoma (HGSOC) incidence and is located in an intergenic region about 44 kb downstream of basonuclin 2 (BNC2) gene. Lifetime number of ovulations is associated with increased risk to develop HGSOC, probably because of cell damage of extrauterine Müllerian epithelium by ovulation-induced oxidative stress. However, the impact of low-penetrance HGSOC risk alleles (e.g. rs3814113) on the damage induced by oxidative stress remains unclear...
September 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27899014/differentiation-between-polycystic-ovary-syndrome-and-polycystic-ovarian-morphology-by-means-of-an-anti-m%C3%A3-llerian-hormone-cutoff-value
#12
Do Kyeong Song, Jee-Young Oh, Hyejin Lee, Yeon-Ah Sung
Background/Aims: Although increased serum anti-Müllerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic value has not been determined. We aimed to observe the relationship between the AMH level and PCOS phenotypes and to determine the optimal cutoff value of AMH for the diagnosis of PCOS in young Korean women. Methods: We recruited 207 women with PCOS (120 with PCOM and 87 without PCOM) and 220 regular cycling women with normoandrogenemia (100 with PCOM and 120 without PCOM)...
November 30, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27895452/laparoscopically-assisted-treatment-of-transverse-testicular-ectopia-with-persistent-m%C3%A3-llerian-duct-syndrome-a-case-report-and-review-of-the-literature
#13
I Valioulis, V Simaioforidis, K Syllas
BACKGROUND: Transverse testicular ectopia coexisting with persistent Müllerian duct syndrome is a rare malformation and evidence regarding the optimal treatment of these patients is still unclear. Description of the case: We present the case of a 4-month-old boy in whom laparoscopy was utilized for the surgical correction of transverse testicular ectopia and excision of Müllerian remnants. CONCLUSION: Based on current literature and the presented case, we support that laparoscopy is a feasible and safe procedure in patients with transverse testicular ectopia and persistent Müllerian duct syndrome...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27894151/value-of-the-ultrasound-in-the-study-of-ovarian-reserve-for-prediction-of-oocyte-recovery
#14
Meire Spressão, Antonio Hélio Oliani, Denise Cristina Mós Vaz Oliani
Purpose To identify which methods used in the assessment of the ovarian reserve are exclusive or complementary to identify the best response to follicle development. Methods Retrospective cohort study, involving patients undergoing assisted reproduction treatment at the Instituto de Medicina Reprodutiva e Fetal, from April 2009 to July 2014. Age, biochemical tests, and ultrasound were assessed. The data were analyzed to predict the follicular development and the relation between them, using, for statistical analysis, Statistical Package for Social Sciences software...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27882049/different-effects-of-myoinositol-plus-folic-acid-versus-combined-oral-treatment-on-androgen-levels-in-pcos-women
#15
Ali Cenk Ozay, Ozlen Emekci Ozay, Recep Emre Okyay, Erkan Cagliyan, Tuncay Kume, Bulent Gulekli
Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC). We aimed to examine myo-ins effects on anti-Mullerian hormone (AMH) levels and compare them with those ones obtained administering COC. In this prospective study, 137 PCOS patients, diagnosed according to Rotterdam criteria and admitted to the Reproductive Endocrinology and Infertility Outpatient Clinic at Dokuz Eylul University (Izmir, Turkey), were included...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27880944/opportunistic-salpingectomy-does-not-affect-ovarian-reserve-or-surgical-outcomes-in-patients-undergoing-laparoscopic-myomectomy
#16
Taejong Song, San-Hui Lee, Woo Young Kim, Eun Jin Heo, Tae-Joong Kim
OBJECTIVE: To determine whether opportunistic salpingectomy in patients undergoing laparoscopic myomectomy has any deleterious effects on ovarian reserve and surgical risk. STUDY DESIGN: We performed a retrospective review of patients who had no desire for future child bearing and who were undergoing laparoscopic myomectomy for symptomatic myomas at 4 institutions. Among them, 41 patients concurrently underwent opportunistic salpingectomy (the opportunistic salpingectomy group) and 65 patients did not undergo salpingectomy at the time of laparoscopic myomectomy (the no-salpingectomy group)...
November 24, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27879453/effects-of-supplementation-of-human-endometriotic-fluids-on-in-vitro-mouse-preantral-follicle-culture
#17
Seul Ki Kim, Byung Chul Jee, Seok Hyun Kim
This study aimed to investigate the potential detrimental effect of human endometriotic fluids (EFs) on in vitro growth of mouse preantral follicles. Preantral follicles (isolated from ovaries of 7- to 8-week-old mice) were cultured in growth medium for 10 days and then in maturation medium for 2 days. During in vitro culture, EF supernatants (0%, 2.5%, 5%, and 10%) were supplemented. Meiotic spindle integrity of metaphase II (MII) oocytes was analyzed. Hormone (17β-estradiol and anti-Müllerian hormone [AMH]) levels in the final spent media were measured by enzyme-linked immunosorbent assay...
November 21, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27871721/roles-of-human-epididymis-protein-4-carbohydrate-antigen-125-inhibin-b-and-anti-m%C3%A3-llerian-hormone-in-the-differential-diagnosis-and-follow-up-of-ovarian-granulosa-cell-tumors
#18
Ulla-Maija Haltia, Marianne Hallamaa, Johanna Tapper, Johanna Hynninen, Henrik Alfthan, Bhanu Kalra, Olli Ritvos, Markku Heikinheimo, Leila Unkila-Kallio, Antti Perheentupa, Anniina Färkkilä
OBJECTIVE: Evaluation of circulating tumor markers in ovarian cancer is crucial for optimal patient care. The goal of this study was to verify the most accurate circulating tumor markers for the diagnosis and follow-up of adult-type granulosa cell tumors (AGCTs). METHODS: The levels of circulating human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125), together with AGCT markers inhibin B and anti-Müllerian hormone (AMH), were measured in 135 samples from AGCT patients, 37 epithelial ovarian carcinoma (EOC) patients, and 40 endometrioma (ENDO) patients...
November 18, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27870902/sleep-duration-exercise-shift-work-and-polycystic-ovarian-syndrome-related-outcomes-in-a-healthy-population-a-cross-sectional-study
#19
Audrey J R Lim, Zhongwei Huang, Seok Eng Chua, Michael S Kramer, Eu-Leong Yong
CONTEXT: Few studies have examined the associations between sleep duration, shiftwork, and exercise to the infrequent menstruation, hyperandrogenism, and ovarian morphological changes observed in women with polycystic ovarian syndrome (PCOS). OBJECTIVE: To examine whether lifestyle factors, including short sleep duration, insufficient exercise, and shiftwork, alone or in combination, are associated with the reproductive and metabolic abnormalities typical of PCOS in a healthy population...
2016: PloS One
https://www.readbyqxmd.com/read/27867926/a-case-of-solitary-brain-metastasis-from-uterine-mullerian-adenosarcoma-with-sarcomatous-overgrowth
#20
Suk Bo Hong, Min Jung Kim, Ji Yeon Kwon, Seok Jin Choi, Eun Young Kim, Joohan Lim
Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment...
October 2016: Brain Tumor Research and Treatment
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