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https://www.readbyqxmd.com/read/29242018/current-practice-in-cytoreductive-surgery-and-hipec-for-metastatic-peritoneal-disease-spanish-multicentric-survey
#1
Rafael Morales-Soriano, Neus Esteve-Pérez, Juan José Segura-Sampedro, Pedro Cascales-Campos, Pedro Barrios
INTRODUCTION: Radical Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), has been proposed as the current standard of treatment for metastatic peritoneal disease by several tumors. Despite its widely utilization, there seems to be a great variability in their organization, clinical practice, and safety among centers. AIM OF THE STUDY: To obtain updated information on clinical practice in different perioperative areas of the CRS-HIPEC...
December 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29240601/efficacy-of-transanal-drainage-tube-placement-after-modified-posterior-pelvic-exenteration-for-primary-ovarian-cancer
#2
Kazuyoshi Kato, Kohei Omatsu, Maki Matoda, Hidetaka Nomura, Sanshiro Okamoto, Hiroyuki Kanao, Kuniko Utsugi, Nobuhiro Takeshima
OBJECTIVE: The aim of this study was to investigate the clinical usefulness of the placement of a transanal drainage tube (TDT) to prevent anastomotic leakage after a modified posterior pelvic exenteration (MPPE) for the treatment of primary ovarian cancer. METHODS: We performed a retrospective review of all the consecutive patients who had undergone an MPPE for primary ovarian, tubal, or peritoneal cancer between October 2012 and November 2016 at our institution...
December 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29238881/peritoneal-carcinomatosis-of-urachus-origin-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-an-international-registry-of-36-patients
#3
Frederic Mercier, Guillaume Passot, Laurent Villeneuve, Edward A Levine, Yutaka Yonemura, Diane Goéré, Paul H Sugarbaker, Christelle Marolho, David L Bartlett, Olivier Glehen
PURPOSE: Peritoneal carcinomatosis or pseudomyxoma peritonei from urachus is a rare form of presentation, often diagnosed at an advanced state of tumor burden. Because of its rarity, little is known about its natural history, prognosis, or optimal treatment. We searched a large international multicenter database of peritoneal surface disease to identify cases of peritoneal carcinomatosis of urachus that were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at expert centers...
December 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29232471/cytoreductive-surgery-for-ovarian-cancer-quality-assessment
#4
A H Brand, P A DiSilvestro, J Sehouli, J S Berek
Surgery is the cornerstone of treatment of ovarian cancer. Given the importance of achieving no or minimal macroscopic residual disease at primary surgery, performing an assessment of the quality of ovarian cancer surgery is crucial. Assessing the quality of care and surgical outcome allows us to establish baseline information, set standards of care and clear priorities, enable benchmarking against peers, and sustain quality improvement. We know that suboptimal care exists and variation in outcomes results...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29229138/abdominal-wall-reconstruction-after-cytoreduction-surgery-hyperthermic-intraperitoneal-chemotherapy
#5
Anthony J Scholer, Joseph B Oliver, Jesus Rosado, Jimmy S Patel, Lindsay J Lynch, Kevin M Spiegler, Karen Houck, Ravi J Chokshi
BACKGROUND: Cytoreduction surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival and decrease recurrence of peritoneal metastasis in a select population of patients. Abdominal wall resection is often needed to achieve complete CRS and the extent of abdominal wall resection may necessitate abdominal wall reconstruction (AWR). We sought to investigate if postoperative morbidity and mortality was increased in patients who underwent AWR with CRS-HIPEC (AWR group) compared to CRS-HIPEC without AWR (non-AWR group) and to identify if patient, tumor, and operative risk factors were associated with poor outcomes following AWR...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29222269/current-treatment-of-double-hit-and-double-expressor-lymphoma
#6
REVIEW
Patrick M Reagan, Andrew Davies
A 60-year-old female presented with abdominal pain and distension. Following computed tomography scans of the abdomen and pelvis, she was taken urgently to the operating room, with the belief that she had appendicitis with perforation. At laparotomy, the findings were consistent with an ovarian carcinoma; there was extensive infiltration of the ovary, bowel, and omental deposits. Cytoreductive surgery was performed including total abdominal hysterectomy and bilateral salpingo-oophorectomy. The final pathology, however, revealed infiltration with medium-sized atypical lymphoid cells positive for CD20, CD10, MYC, BLC2, and BCL6 by immunohistochemistry...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29218669/laparoscopy-as-a-useful-selection-tool-for-patients-with-prior-surgery-and-peritoneal-metastases-suitable-for-multimodality-treatment-strategies
#7
Philipp von Breitenbuch, Thomas Boerner, Tonia Jeiter, Pompiliu Piso, Hans J Schlitt
BACKGROUND: Complete macroscopic cytoreduction in patients with peritoneal carcinomatosis (PC) is the basic requirement for long-term survival. Diagnostic laparoscopy (DL) can be difficult and of limited clinical value secondary to postoperative or tumor-induced adhesions. The aim of this study was to evaluate the role of DL in patients with prior surgery and PC. METHODS: The database of the surgical department of the University Medical Center of Regensburg was reviewed (9/2010-10/2014) selecting for DL in patients with PC...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29214450/effects-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-in-the-treatment-of-goblet-cell-carcinoma-a-prospective-cohort-study
#8
Anders Husted Madsen, Morten Ladekarl, Gerda Elisabeth Villadsen, Henning Grønbæk, Mette Møller Sørensen, Katrine Stribolt, Vic Jilbert Verwaal, Lene Hjerrild Iversen
BACKGROUND: Goblet cell carcinoma (GCC) of the appendix is a rare disease. Treatment options vary according to disease staging. Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) may improve survival in patients with peritoneal spreading. OBJECTIVE: The aim of this study was to examine the prognosis of patients with appendiceal GCC treated per protocol, and to evaluate the results of CRS+HIPEC in cases of peritoneal spreading...
December 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29203996/metachronous-synchronous-sternal-and-colonic-metastasis-with-asymptomatic-colo-colic-fistula-from-carcinoma-ovary-rare-presentation-of-ovarian-cancer
#9
Srinivas K G, Abid Ali Mirza, Shivananda Swamy, Amarendra S, Gopinath Ks
Ovarian cancer is one of the most common gynecological cancers worldwide. It is the third leading cause of cancer among women in India. Metastatic disease to the visceral organs from ovarian cancer occurs as a terminal event in the natural history of the disease. In particular, spread to the bone and large bowel is infrequently described. The risk of distant metastasis increases in a recurrent setting. We describe a case of a 77-year-old lady, who was diagnosed for ovarian carcinoma in 2007 and underwent primary cytoreductive surgery, stage IIIc...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203987/ovarian-cancer-in-young-women
#10
Eileen Lalrinpuii, Pallipuram Seshadrinathan Bhageerathy, Ajit Sebastian, Lakshmanan Jeyaseelan, VinothaThomas, Anitha Thomas, Rachel Chandy, Abraham Peedicayil
It is not clear how often epithelial tumours affect young women. This study aimed to evaluate the clinico-pathological pattern and survival outcome of women, 40 years and younger, with cancer ovary. Women 40 years and younger, operated between 2008 and 2012 for ovarian cancer, were retrospectively recruited and followed up. The study design was descriptive as well as a survival analysis. A hybrid of retrospective and prospective cohort design was used for risk factor analysis. Of the 115 women less than 40 years being operated for probable ovarian cancer, 22 were excluded for various reasons...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203986/crs-and-hipec-for-pmp-use-of-the-lc-cusum-to-determine-the-number-of-procedures-required-to-attain-a-minimal-level-of-proficiency-in-delivering-the-combined-modality-treatment
#11
Aditi Bhatt, Antony George, Sanket Mehta
The learning curve for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP) which peaks at 90 procedures for the surgeon may take several years to reach. The cumulative summation (CUSUM) test of the learning curve (LC-CUSUM) was used to assess the safety of the procedure (minimal level of proficiency for the surgeon) in terms of morbidity, mortality, and completeness of cytoreduction and early oncological failure before the peak of the learning curve had been reached...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203984/ovarian-metastases-of-colorectal-origin-treatment-patterns-and-factors-affecting-outcomes
#12
Praveen S Kammar, Reena Engineer, Prachi S Patil, Vikas Ostwal, T S Shylasree, Avanish P Saklani
The purpose of this study is to evaluate the patterns of treatment and factors affecting outcomes in ovarian metastases of colorectal origins treated at our institution and to assess the response of ovarian metastases to chemotherapy. Survival in R0 and R+ resections and patients receiving only chemotherapy is also analyzed. This is a retrospective study of 25 patients registered between January 2012 and December 2015. Patient's age, disease status, mode of presentation, disease spread, mode of treatment, response to chemotherapy, completeness of resection, histology, and outcomes were considered as variables for analysis...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29195926/clinicopathologic-characteristics-associated-with-long-term-survival-in-advanced-epithelial-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-data-study
#13
C A Hamilton, A Miller, Y Casablanca, N S Horowitz, B Rungruang, T C Krivak, S D Richard, N Rodriguez, M J Birrer, F J Backes, M A Geller, M Quinn, M J Goodheart, D G Mutch, J J Kavanagh, G L Maxwell, M A Bookman
OBJECTIVE: To identify clinicopathologic factors associated with 10-year overall survival in epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC), and to develop a predictive model identifying long-term survivors. METHODS: Demographic, surgical, and clinicopathologic data were abstracted from GOG 182 records. The association between clinical variables and long-term survival (LTS) (>10years) was assessed using multivariable regression analysis. Bootstrap methods were used to develop predictive models from known prognostic clinical factors and predictive accuracy was quantified using optimism-adjusted area under the receiver operating characteristic curve (AUC)...
November 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29193085/elevated-brain-natriuretic-peptide-bnp-is-an-early-marker-for-patients-at-risk-for-complications-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs%C3%A2-%C3%A2-hipec
#14
Sarah B Fisher, Safia Rafeeq, Ken Hess, Travis E Grotz, Paul Mansfield, Richard Royal, Brian Badgwell, Jason Fleming, Keith Fournier, Gary N Mann
BACKGROUND: Elevated BNP is associated with adverse cardiac outcomes after noncardiac surgery. We assessed BNP values as markers of perioperative fluid status and their correlation with major/cardiopulmonary (CP) complications following CRS + HIPEC. METHODS: Fluid balance, BNP levels, and morbidity data were collected for all patients undergoing CRS + HIPEC between 6/2014 and 2/2016. RESULTS: One hundred and twenty-nine patients underwent CRS + HIPEC for appendiceal adenocarcinoma (n = 99), mesothelioma (n = 16), and colon cancer (n = 14)...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29192741/taribo-trial-targeted-therapy-with-or-without-nephrectomy-in-metastatic-renal-cell-carcinoma-liquid-biopsy-for-biomarkers-discovery
#15
Elena Verzoni, Raffaele Ratta, Paolo Grassi, Roberto Salvioni, Silvia Stagni, Rosanna Montone, Giovanni Fucà, Vera Cappelletti, Carolina Reduzzi, Ugo De Giorgi, Giuseppe Procopio
PURPOSE: Two randomized trials in the cytokine era showed that cytoreductive nephrectomy (CN) had a role in metastatic renal cell carcinoma (mRCC), increasing life expectancy. The survival benefit of tyrosine kinase inhibitors (TKIs), including first-line sunitinib and pazopanib, in mRCC has been demonstrated, but the majority of patients enrolled in the pivotal phase III studies had undergone nephrectomy. Therefore it is unknown if similar survival benefit with targeted agents could be achieved without CN...
November 29, 2017: Tumori
https://www.readbyqxmd.com/read/29192414/outcomes-of-patients-with-advanced-stage-ovarian-cancer-with-intestinal-metastasis
#16
Eyüp Kebapcı, Varol Gülseren, Cem Tuğmen, Mehmet Gökçü, Ulaş Solmaz, İsmail Sert, Mustafa Kocaer, Mehmet Özer, Mustafa Ölmez, Muzaffer Sancı
OBJECTIVES: The aim of this study is to evaluate the results of advanced stage (stage IIIB-IVB) ovarian cancer (OC) patients with intestinal metastasis, and to investigate the factors that affect survival. MATERIAL AND METHODS: Patients who underwent cytoreductive surgery (CS) for FIGO stage IIIB-IVB OC with metastasis in the intestinal system, at Tepecik Research and Treatment Hospital between 2008-2014, were analyzed retrospectively. Patients with borderline ovarian tumor; those who had previously undergone radiation therapy and/or hysterectomy and patients having secondary or tertiary cytoreduction were excluded and 49 patients were included and analyzed in this study...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29192372/prediction-of-resectability-in-pseudomyxoma-peritonei-with-a-new-ct-score
#17
Morgane Bouquot, Anthony Dohan, Etienne Gayat, Maxime Barat, Olivier Glehen, Marc Pocard, Pascal Rousset, Clarisse Eveno
BACKGROUND: Curative treatment of pseudomyxoma peritonei (PMP) is complete cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). OBJECTIVE: The aim of this study was to build and evaluate a preoperative imaging score to predict resectability. PATIENTS AND METHODS: Between 2007 and 2014, all PMP patients in two tertiary reference centers who underwent laparotomy with intent to undergo CRS and HIPEC were included in this study retrospectively...
November 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29191688/diaphragm-and-lung-preserving-surgery-with-hyperthermic-chemotherapy-for-malignant-pleural-mesothelioma-a-10-year-experience
#18
Marcello Carlo Ambrogi, Pietro Bertoglio, Vittorio Aprile, Antonio Chella, Stylianos Korasidis, Gabriella Fontanini, Olivia Fanucchi, Marco Lucchi, Alfredo Mussi
BACKGROUND: The best surgical treatment for malignant pleural mesothelioma is still under a debate, but recent evidence points toward a less-invasive approach to reduce morbidity and mortality. We reported our 10-year experience of a limited surgical approach associated with hyperthermic intrathoracic chemotherapy (HITHOC). MATERIAL AND METHODS: Between 2005 and 2014, patients with epithelioid or biphasic malignant pleural mesothelioma were treated with lung-diaphragm-pericardium-sparing pleurectomy associated with double-drug HITHOC; at least 3 cycles of adjuvant chemotherapy were then administered...
November 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29187468/modeling-ca-125-during-neoadjuvant-chemotherapy-for-predicting-optimal-cytoreduction-and-relapse-risk-in-ovarian-cancer
#19
Simon Ducoulombier, François Golfier, Olivier Colomban, David Benayoun, Pierre-Adrien Bolze, Michel Tod, Benoit You
AIM: To investigate the prognostic value of modeled CA-125 kinetic parameters regarding surgery outcomes and time to second-line chemotherapy in a population of ovarian cancer patients treated with neoadjuvant chemotherapy followed by interval cytoreduction. PATIENTS AND METHODS: This retrospective study included consecutive patients with FIGO stage IIIc/IV ovarian cancer treated between 2006 and 2014. We characterized CA-125 kinetics and identified modeled kinetic parameters...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29187451/cold-atmospheric-plasma-cap-and-cap-stimulated-cell-culture-media-suppress-ovarian-cancer-cell-growth-a-putative-treatment-option-in-ovarian-cancer-therapy
#20
Dominique Koensgen, Ilma Besic, Denis Gümbel, Anne Kaul, Martin Weiss, Karoline Diesing, Axel Kramer, Sander Bekeschus, Alexander Mustea, Matthias B Stope
BACKGROUND/AIM: Ovarian cancer (OC) is a gynecologic tumor with poor prognosis. Despite radical cytoreductive surgery and platinum-based adjuvant systemic treatment, OC will relapse in the majority of the cases. Thus, cold atmospheric plasma (CAP), a highly reactive physical state bearing diverse biological activities being suited for anticancer therapy, may be a promising option in OC therapy. MATERIALS AND METHODS: OC cell lines were exposed either directly to the CAP or to cell culture medium previously exposed to CAP...
December 2017: Anticancer Research
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