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Cytoreduction surgery

Cindy Alcarraz, Johana Muñiz, Luis Mas, Mivael Olivera, Zaida Morante, Manuel Alvarez, Raul Mantilla, Jhajaira Araujo, Joseph Pinto
To determine the rate of optimal cytoreduction in patients with advanced ovarian cancer who received neoadjuvant chemotherapy with dose-dense carboplatin and paclitaxel followed by interval debulking surgery (IDS). A retrospective study of a series of cases of Peruvian women treated with neoadjuvant chemotherapy with carboplatin (6 AUC mg/mL/min) and paclitaxel (80 mg/m2 weekly) followed by IDS, at the National Institute of Neoplastic Diseases during the 2010-2014 period. The 41 patients who made it to the interval surgery had a median age of 59 years (range: 47-73 years)...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
Alyssa M Wield, Christine S Walsh, B J Rimel, Ilana Cass, Beth Y Karlan, Andrew J Li
Data from colon, breast and prostate cancers suggest that aspirin users have reduced mortality. While the direct mechanism remains uncertain, aspirin can suppress the COX-dependent and independent pathways involved in tumor progression. We hypothesized that aspirin users with clear cell ovarian cancer would have improved survival outcomes. We performed a retrospective review of patients with clear cell ovarian cancer diagnosed between 1995 and 2010, and followed outcomes through 2016. Patients underwent primary cytoreductive surgery followed by platinum-based chemotherapy...
August 2018: Gynecologic Oncology Reports
Rebecca Fish, Andrew G Renehan, Grant Punnett, Omer Aziz, Paul Fulford, Chelliah Selvasekar, Malcolm Wilson, Rebecca Halstead, Sarah T O'Dwyer
AIM: Pseudomyxoma peritonei (PMP) is a rare neoplasm of the appendix, which if untreated disseminates throughout the abdominal cavity and generates considerable morbidity. Since 2002 in the UK, patients with PMP have been managed via two nationally commissioned centres. We evaluated referrals and treatment pathways over time at the Manchester centre. METHOD: Data from all patients referred with suspected PMP were prospectively collected (2002-2015). Definitive treatment was cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC)...
June 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Christina N Cordeiro Mitchell, Tricia Murdock, Amanda N Fader, Rebecca L Stone
•Abnormal cell free DNA results may indicate occult maternal malignancy.•Cesarean-cytoreductive surgery is feasible even with significant disease burden.•Carboplatin/paclitaxel is first line for epithelial ovarian cancer in pregnancy.
May 2018: Gynecologic Oncology Reports
Bharat Panuganti, Ea-Sle Chang, Cyril W Helm, Theresa Schwartz, Eddy C Hsueh, Jinhua Piao, Jinping Lai, Jula Veerapong
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are combined to treat peritoneal surface malignancies (PSM). The objective of cytoreduction is to eradicate macroscopic disease, while HIPEC addresses residual microscopic disease. Currently, there are no protocols guiding treatment of cirrhotic patients with PSM. We report the case of a cirrhotic patient with signet ring cell (SRC) appendiceal adenocarcinoma who underwent normothermic, as opposed to hyperthermic intraperitoneal chemotherapy (IPC)...
June 2018: Gastroenterology Research
Lu Qin, Huming Huang, Mengjie Chen, Yuejuan Liang, He Wang
BACKGROUND: The treatment of newly diagnosed advanced epithelial ovarian cancer (EOC) was predicted by an ovarian cancer computed tomography (CT) evaluation model combined with serum CA125. METHODS: Clinical data for 194 patients with advanced EOC treated with neoadjuvant chemotherapy (NACT) combined with interval debulking surgery (IDS) or primary debulking surgery (PDS) were retrospectively analyzed, and the appropriate treatment was predicted by comparing the subgroup differences in intraoperative situations, postoperative situations and survival rates...
June 18, 2018: Journal of Ovarian Research
Isabella Cadena, Victoria P Werth, Pascale Levine, Annie Yang, Andrea Downey, John Curtin, Franco Muggia
Could hydroxychloroquine and quinacrine antimalarial therapy for dermatomyositis later attributed to a paraneoplasic manifestation of an ovarian cancer enhance its subsequent response to chemotherapy? Five months after being diagnosed with dermatomyositis, while somewhat improved with hydroxychloroquine, quinacrine and methotrexate, this 63-year-old woman presented with an advanced intra-abdominal epithelial ovarian cancer documented (but not resected) at laparotomy. Neoadjuvant carboplatin/paclitaxel resulted in remarkable improvement of symptoms, tumour markers and imaging findings leading to thorough cytoreductive surgery at completion of five cycles...
2018: Ecancermedicalscience
Qian Qin, Veronica B Ajewole, Tiffany G Sheu, Rachel Donohue, Monisha Singh
Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly undifferentiated, aggressive malignancy that primarily affects young women. Due to its early onset, unclear familial history and vague presenting symptoms, most SCCOHT patients present late with advanced disease. The prognosis is extremely poor, with <10% disease-free survival for advanced stages. Although several therapeutic regimens have been proposed, to date there is no consensus on the optimal strategy. Here, we describe a successful case of advanced-stage SCCOHT of the left ovary treated with cytoreductive surgery, semi-intense chemotherapy, high-dose consolidative chemotherapy, autologous hematopoietic stem cell transplantation and pelvic radiation with long-term survival...
2018: Ecancermedicalscience
Audrey Tieko Tsunoda, Reitan Ribeiro, Rosilene Jara Reis, Carlos Eduardo Mattos da Cunha Andrade, Renato Moretti Marques, Glauco Baiocchi, Fabio Fin, Paulo Henrique Zanvettor, Deraldo Falcao, Thales Paulo Batista, Bruno Roberto Braga Azevedo, Gustavo Guitmann, Suzana Arenhart Pessini, João Soares Nunes, Leonardo Martins Campbell, José Clemente Linhares, Felipe José Fernandez Coimbra
Surgical management in epithelial ovarian cancer (EOC) has a significant impact in overall survival (OS) and progression free survival (PFS). Brazilian Society of Surgical Oncology (BSSO) supported a taskforce with experts for consensus: experienced and specialized trained surgeons, in cancer centers, provide the best EOC surgery. Laparoscopic and/or radiological staging prognosticate the possibility of complete cytoreduction (CC0) and help to reduce unnecessary laparotomies. Surgical techniques were reviewed...
June 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Tingyan Shi, Rong Jiang, Jinjin Yu, Huijuan Yang, Dongsheng Tu, Zhiyuan Dai, Yang Shen, Yuqin Zhang, Xi Cheng, Huixun Jia, Ruiqin Tu, Huaying Wang, Jie Tang, Yuting Luan, Shumo Cai, Rongyu Zang
BACKGROUND: We assessed the efficacy of adding intraperitoneal (IP) chemotherapy to standard first-line intravenous (IV) chemotherapy in epithelial ovarian cancer (EOC) patients. METHODS: Patients with stage IIIC-IV EOC who underwent optimal debulking surgery were randomly assigned to four cycles of weekly IP chemotherapy with cisplatin (50 mg/m2 ) and etoposide (100 mg/m2 ) followed by six cycles of IV chemotherapy every 3 weeks (IP/IV arm), or were administered IV chemotherapy alone (IV arm)...
June 14, 2018: British Journal of Cancer
Tayfun Toptas, Elif Pestereli, Tayup Simsek, Selen Bozkurt, Gulgun Erdogan, Seyda Karaveli
Aims: To investigate whether the presence of serous tubal intraepithelial carcinoma (STIC) is associated with clinical outcomes in a nonselected (unknown BRCA status) cohort of patients with a high-grade serous carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. Settings and Design: A prospective case-series with planned data collection. Subjects and Methods: The study was conducted in a total of 131 patients, who underwent primary cytoreductive surgery between 2007 and 2012...
April 2018: Journal of Cancer Research and Therapeutics
Audrius Dulskas, Tomas Poskus, Eligijus Poskus, Kestutis Strupas
Background: Appendiceal mucinous tumour (AMT) is a very uncommon disease. We aimed to evaluate preoperative and postoperative characteristics as well as long-term outcomes of patients with appendiceal mucinous adenomas and peritoneal pseudomyxoma (PMP). Methods: A consecutive cohort of patients diagnosed with AMT were included in the study. Tumour recurrence and the development of PMP was diagnosed based on the patients' complaints, physical examination, imaging studies, and biopsy results...
April 2018: Visceral Medicine
Sanket Mehta, Lilian Schwarz, John Spiliotis, Mao-Chih Hsieh, Eduardo H Akaishi, Diane Goere, Paul H Sugarbaker, Dario Baratti, François Quenet, David L Bartlett, Laurent Villeneuve, Vahan Kepenekian
INTRODUCTION: Peritoneal metastasis (PM) of hepatocellular carcinoma (HCC) without distant spread are rare. The related prognosis is poor without standard treatment available. The role of cytoreduction surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is poorly documented. METHODS: An international multicentric cohort was constituted by retrospective analysis of 21 patients undergoing CRS/HIPEC for PM of HCC between 1992 and 2016 from 10 reference centers of PSOGI...
May 28, 2018: European Journal of Surgical Oncology
Paul H Sugarbaker
PURPOSE OF REVIEW: Peritoneal metastases may occur from a majority of cancers that occur within the abdomen or pelvis. When cancer spread to the peritoneal surfaces is documented, a decision regarding palliation vs. an aggressive approach using cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy must be made. The perioperative chemotherapy may be hyperthermic intraperitoneal chemotherapy (HIPEC) administered in the operating room or early postoperative intraperitoneal chemotherapy (EPIC) administered in the first 4 or 5 postoperative days...
June 8, 2018: Current Oncology Reports
Armando Sardi, Carlos A Muñoz-Zuluaga, Michelle Sittig, Teresa Diaz-Montes
Peritoneal sarcomatosis from uterine sarcoma is a rare disease with no effective treatment and poor prognosis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has successful results in peritoneal carcinomatosis from gastrointestinal/gynecological origins. We show that CRS/HIPEC is safe, feasible, and may benefit selected patients with peritoneal sarcomatosis from uterine sarcoma.
June 2018: Clinical Case Reports
Oliver S Eng, Mustafa Raoof, Andrew M Blakely, Xian Yu, Stephen J Lee, Ernest S Han, Mark T Wakabayashi, Bertram Yuh, Byrne Lee, Thanh H Dellinger
BACKGROUND AND OBJECTIVES: Cytoreductive surgery with complete macroscopic resection in patients with ovarian cancer is associated with improved survival. Institutional reports of combined upper and lower abdominal cytoreductive surgery for more advanced disease have described multidisciplinary approaches. We sought to investigate outcomes in patients undergoing cytoreductive surgery in patients with upper and lower abdominal disease at our institution. METHODS: Patients who underwent cytoreductive surgery for ovarian malignancies from 2008 to 2015 were retrospectively identified from an institutional database...
June 7, 2018: Journal of Surgical Oncology
Vivek Subbiah, Salah-Eddine Lamhamedi-Cherradi, Branko Cuglievan, Brian A Menegaz, Pamela Camacho, Winston W Huh, Vandhana Ramamoorthy, Peter M Anderson, Raphael E Pollock, Dina Lev, Wei Qiao, Mary Frances McAleer, Robert S Benjamin, Shreyaskumar Patel, Cynthia E Herzog, Najat C Daw, Barry W Feig, Alexander J Lazar, Andrea Hayes-Jordan, Joseph A Ludwig
Purpose Desmoplastic small round cell tumor (DSRCT), which harbors EWSR1-WT1 t(11;22)(p13:q12) chromosomal translocation, is an aggressive malignancy that typically presents as intra-abdominal sarcomatosis in young males. Given its rarity, optimal treatment has not been defined. Experimental Design We conducted a retrospective study of 187 DSRCT patients treated at MD Anderson Cancer Center over two decades. Univariate and multivariate regression analyses were performed. We determined whether chemotherapy, complete cytoreductive surgery (CCS), hyperthermic intraperitoneal cisplatin (HIPEC), and/or whole abdominal radiation (WART) improve overall survival in DSRCT patients...
June 5, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Grace Hwei Ching Tan, Claramae Shulyn Chia, Sze Huey Tan, Khee Chee Soo, Melissa Ching Ching Teo
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are used in the management of selected peritoneal malignancies. While most patients achieve long-term disease-free survival, there remains a group with early recurrence (ER). We aim to investigate the clinical factors associated with ER. METHODS: A retrospective review of a prospectively maintained database of CRS-HIPEC patients treated between April 2001 and Feb 2016 was performed...
June 5, 2018: International Journal of Clinical Oncology
Clemens Tempfer, Urs Giger-Pabst, Ziad Hilal, Askin Dogan, Günther A Rezniczek
BACKGROUND: Systemic chemotherapy is not effective in patients with peritoneal carcinomatosis (PC) and only a minority of affected patients is eligible for cytoreductive surgery. Intraperitoneal chemotherapy may provide a therapy alternative for these patients. METHODS: We performed a systematic review of clinical and experimental evidence on the safety and efficacy of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with PC and provide clinical recommendations based on the available evidence...
June 4, 2018: Archives of Gynecology and Obstetrics
Lindsey Winer, Francisco I Macedo, Abdullah Alfawaz, Antonio Sommariva, Giovanni Cecchetto, Holly L Neville, Mecker G Möller
The management of pediatric abdominopelvic angiosarcoma remains unclear due to limited clinical experience. Herein, we presented the first 2 pediatric patients with abdominal angiosarcoma who were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant therapy. The first patient is alive with recurrent disease at 1-year follow-up and the second patient remains disease free after 1 year. CRS and HIPEC should be considered as a therapeutic option in the management of pediatric abdominal angiosarcomas...
May 31, 2018: Journal of Pediatric Hematology/oncology
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