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Cytoreduction surgery

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https://www.readbyqxmd.com/read/29452599/feasibility-and-acceptability-of-pre-operative-physical-activity-to-improve-patient-outcomes-after-major-cancer-surgery-study-protocol-for-a-pilot-randomised-controlled-trial-pepa-trial
#1
Daniel Steffens, Jane Young, Paula R Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger, Michael Solomon
BACKGROUND: There is a need for evidence of the effectiveness of pre-operative exercise for patients undergoing major cancer surgery; however, recruitment to such trials can be challenging. The PrE-operative Physical Activity (PEPA) Trial will establish the feasibility and acceptability of a pre-operative exercise programme aimed to improve patient outcomes after cytoreductive surgery and pelvic exenteration. The secondary aim is to obtain pilot data on the likely difference in key outcomes (post-operative complications, length of hospital stay, post-operative functional capacity and quality of life) to inform the sample size calculation for the substantive randomised clinical trial...
February 17, 2018: Trials
https://www.readbyqxmd.com/read/29431036/outcomes-of-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-mesothelioma-and-predictors-of-survival
#2
Syeda Nadia Shah Gilani, Akash Mehta, Alfonso Garcia-Fadrique, Babatunde Rowaiye, Veronika Jenei, Sanjeev Dayal, Kandiah Chandrakumaran, Norman Carr, Faheez Mohamed, Tom Cecil, Brendan Moran
BACKGROUND: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) benefits selected patients with peritoneal mesothelioma. We present the outcomes of this treatment strategy in a UK peritoneal malignancy national referral centre. METHODS: Observational retrospective analysis of data prospectively collected in a dedicated peritoneal malignancy database between March 1998 and January 2016. RESULTS: Of 1586 patients treated for peritoneal malignancy, 76 (4...
February 12, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29429947/hospital-readmission-rates-and-risk-factors-for-readmission-following-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-for-peritoneal-surface-malignancies
#3
Yael Dreznik, Aviad Hoffman, Tamar Hamburger, Almog Ben-Yaacov, Yossi Dux, Harel Jacoby, Yaniv Berger, Aviram Nissan, Mordechai Gutman
BACKGROUND: Cytoreductive surgery and Hyperthermic intra-peritoneal chemotherapy (CRS/HIPEC) for peritoneal surface malignancies is associated with high morbidity. The increased numbers of patients undergoing CRS/HIPEC in recent years mandates risk analysis and quality assurance. However, only scarce data exist regarding causative parameters for readmission. The aim of this study was to assess readmission rates and risk factors associated with readmission. METHODS: A retrospective-cohort study including patients from two high-volume centers who underwent CRS/HIPEC surgery between the years 2007-2016 was performed...
February 8, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29429054/incidence-of-leukopenia-and-thrombocytopenia-with-cisplatin-plus-mitomycin-c-versus-melphalan-in-patients-undergoing-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#4
Hakeam A Hakeam, Amal Arab, Ayman Azzam, Zyad Alyahya, Abdelmoneim M Eldali, Tarek Amin
INTRODUCTION: Cytopenia after hyperthermic intraperitoneal chemotherapy (HIPEC) with cytoreductive surgery (CRS) has been reported in non-comparative studies with various chemotherapeutic regimens. This study compared the incidence of leukopenia and thrombocytopenia in patients who underwent CRS/HIPEC and received melphalan or cisplatin plus mitomycin-c (CIS + MMC). METHODS: This retrospective study included patients who underwent CRS/HIPEC at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia from March 2011 to March 2017 and received melphalan 60 mg/m2 or CIS 100 mg/m2 combined with MMC 30 mg/m2...
February 10, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29428475/peritoneal-metastases-invading-the-seminal-vesicles-radiologic-appearance-and-outcome-of-treatment
#5
Paul H Sugarbaker
BACKGROUND: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) may be of greatest benefit if all visible evidence of disease is resected. In some male patients the peritoneal metastases within the pelvis are invasive into the seminal vesicles and complete cytoreduction requires resection of these structures. PATIENTS AND METHODS: From a prospective database of colorectal and appendiceal cancer patients who had CT evidence of seminal vesicle involvement and then had cytoreduction including resection of the seminal vesicles were reviewed...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29426779/complete-cytoreduction-after-five-or-more-cycles-of-neo-adjuvant-chemotherapy-confers-a-survival-benefit-in-advanced-ovarian-cancer
#6
Andrew Phillips, Sudha Sundar, Kavita Singh, James Nevin, Ahmed Elattar, Sean Kehoe, Janos Balega
OBJECTIVES: To assess the impact of 5 or more cycles of neoadjuvant chemotherapy (NACT) and cytoreductive outcomes on overall survival (OS) in patients undergoing interval debulking surgery (IDS) for advanced ovarian cancer. METHODS: A retrospective review of patients receiving NACT followed by IDS between 2007 and 2017. Patients were analysed according to number of NACT cycles received: group 1 consisted of patients receiving ≤4 cycles and group 2 consisted of those receiving ≥5 cycles...
January 31, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29420428/prior-surgical-score-an-analysis-of-the-prognostic-significance-of-an-initial-nondefinitive-surgical-intervention-in-patients-with-peritoneal-carcinomatosis-of-a-colorectal-origin-undergoing-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#7
Bikram K Paul, Chukwuemeka Ihemelandu, Paul H Sugarbaker
BACKGROUND: The prior surgical score estimates the extent of previous surgical intervention by quantitating surgical dissection within 9 abdominopelvic regions. OBJECTIVE: Our aim was to analyze the prognostic significance of the prior surgical score in our cohort of patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of a colorectal origin. DESIGN: This was a retrospective analysis of a prospectively maintained database for all patients treated for peritoneal carcinomatosis of a colorectal origin...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29416655/folate-receptor-%C3%AE-targeted-near-infrared-fluorescence-imaging-in-high-risk-endometrial-cancer-patients-a-tissue-microarray-and-clinical-feasibility-study
#8
Leonora S F Boogerd, Charlotte E S Hoogstins, Katja N Gaarenstroom, Cornelis D de Kroon, Jogchum J Beltman, Tjalling Bosse, Ellen Stelloo, Jaap Vuyk, Philip S Low, Jacobus Burggraaf, Alexander L Vahrmeijer
Objective: Detection and resection of all malignant lesions is pivotal in staging and cytoreductive surgery (CRS) of endometrial cancer (EC). Intraoperative EC detection could be enhanced using OTL-38, a fluorescent-labelled folate receptor-α (FRα) targeted imaging agent. The objectives of this study were to investigate which subgroups of high-risk EC patients express FRα and assess feasibility of intraoperative EC detection using OTL-38. Results: FRα expression on TMA was significantly correlated with tumor type (p < 0...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29412465/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-of-appendicular-and-extra-appendicular-origin
#9
J-B Delhorme, F Severac, G Averous, O Glehen, G Passot, N Bakrin, F Marchal, M Pocard, R Lo Dico, C Eveno, S Carrere, O Sgarbura, F Quenet, G Ferron, D Goéré, C Brigand
BACKGROUND: The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database...
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29409111/pre-operative-core-muscle-index-in-combination-with-hypoalbuminemia-is-associated-with-poor-prognosis-in-advanced-ovarian-cancer
#10
Lesley B Conrad, Haitham Awdeh, Stefany Acosta-Torres, Steven A Conrad, April A Bailey, David S Miller, Jayanthi S Lea
BACKGROUND AND OBJECTIVES: Age and frailty have been correlated with poor clinical outcomes in cancer. Core muscle index (CMI) and nutritional status are integral in assessing frailty. We explored the effect of pre-operative serum albumin and body composition on clinical outcomes in patients with epithelial ovarian cancer (EOC). METHODS: We identified stage III-IV EOC patients undergoing primary cytoreductive surgery from 2007 to 2015. Data were abstracted from medical records...
February 6, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29402501/hoxa4-hoxb3-gene-expression-signature-as-a-biomarker-of-recurrence-in-patients-with-high-grade-serous-ovarian-cancer-following-primary-cytoreductive-surgery-and-first-line-adjuvant-chemotherapy
#11
Katherine R Miller, Jai N Patel, Qing Zhang, Eric J Norris, James Symanowski, Chad Michener, Jalid Sehouli, Ioana Braicu, Darla D Destephanis, Ashley P Sutker, Wendell Jones, Chad A Livasy, Charles Biscotti, Ram N Ganapathi, David L Tait, Mahrukh K Ganapathi
OBJECTIVES: Aberrant homeobox (HOX) gene expression is reported in high-grade serous ovarian carcinoma (HGSOC), however, its prognostic significance remains unclear. METHODS: HOX genes associated with progression-free survival (PFS) in a discovery cohort of primary HGSOC samples with RNA sequencing data, and those previously reported to be associated with clinical outcomes, were selected for qPCR testing in an independent training cohort of primary HGSOC samples (n=71)...
February 2, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29399355/radiation-induced-angiosarcoma-of-the-omentum-diagnosed-by-laparoscopy-a-case-report
#12
Haruko Kunitomi, Kouji Banno, Hayato Iseki, Asako Sera, Azumi Miyauchi, Yusuke Kobayashi, Shigenori Hayashi, Eiichiro Tominaga, Aya Sasaki, Miho Kawaida, Kaori Kameyama, Daisuke Aoki
Angiosarcoma is a rare malignant tumor with an aggressive clinical course and a poor prognosis. Intraperitoneal angiosarcoma, especially originating from the omentum, is extremely rare. We report a case of radiation-induced angiosarcoma of the omentum that arose in a 38-year-old female seven years after concurrent chemoradiotherapy for cervical cancer. The primary tumor was unknown until diagnostic laparoscopy revealed an unresectable omental mass. Pathological examination revealed high-grade malignant cells positive for endothelial markers...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29397879/systematic-second-look-surgery-plus-hipec-in-patients-without-evidence-of-recurrence-at-high-risk-of-carcinomatosis-after-colorectal-cancer-resection
#13
Ángel Serrano Del Moral, Estibalitz Pérez Viejo, Israel Manzanedo Romero, Gil Rodríguez Caravaca, Fernando Pereira Pérez
INTRODUCTION: To analyze the impact of systematic second-look surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC) performed 1 year after resection of the primary tumor, in asymptomatic patients at high risk of developing peritoneal carcinomatosis (PC). METHODS: Between 2012-2016, 33 patients without any sign of peritoneal recurrence on imaging studies were prospectively included in the study and underwent second-look surgery aimed at treating limited PC earlier and were prospectively recorded...
February 2, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29397633/analysis-of-patient-selection-policy-and-pattern-of-recurrence-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-carcinomatosis
#14
Manuela Robella, Marco Vaira, Alice Borsano, Michele DE Simone
BACKGROUND: Actual cure rate and patterns of recurrence after cytoreductive surgery (CRS) associated to hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with colorectal peritoneal carcinomatosis (PC) are not yet well explored. Moreover, the selection policy to this resource-consuming treatment is still a matter of debate. METHODS: From a dataset of 400 CRS+HIPEC performed between October 1996 and December 2015, we selected 54 consecutive patients with colorectal PC...
February 1, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29395315/patterns-of-palliative-care-referral-in-ovarian-cancer-a-single-institution-5%C3%A2-year-retrospective-analysis
#15
Roni Nitecki, Elisabeth J Diver, Mihir M Kamdar, David M Boruta, Marcela C Del Carmen, Rachel M Clark, Annekathryn Goodman, John O Schorge, Whitfield B Growdon
BACKGROUND: The American Society of Clinical Oncology recommends that patients with advanced cancer receive dedicated palliative care services early in their disease course. This investigation serves to understand how palliative care services are utilized for ovarian cancer patients in a tertiary referral center. METHODS: We conducted a retrospective review of women treated for ovarian cancer at our institution from 2010 through 2015. Clinical variables included presence and timing of palliative care referral...
January 27, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29394827/comprehensive-treatment-using-cytoreductive-surgery-combined-with-perioperative-chemotherapy-improved-outcome-of-colorectal-cancer-patients-with-metachronous-peritoneal-metastasis
#16
Yutaka Yonemura, Emel Canbay, Shouzou Sako, Satoshi Wakama, Haruaki Ishibashi, Masamitsu Hirano, Akiyoshi Mizumoto, Nobuyuki Takao, Masumi Ichinose, Kousuke Noguchi, Shunsuke Motoi, Yang Liu, Yan Li, Keizou Taniguchi
To analyze the role of cytoreductive surgery(CRS)plus perioperative chemotherapy on the survival of colorectal cancer(CRC)patients with metachronous peritoneal metastasis(PM). A comprehensive treatment consisting of neoadjuvant chemotherapy plus CRS was performed in 291 CRC patients. Among the 291, 142 and 149 patients had synchronous and metachronous PM, respectively. The results showed no survival difference between the 2 groups. Median survival time(MST)of patients with metachronous PM with complete cytoreduction(CCR-0), small bowel(SB)-PCIC2, PCIC14 and differentiated histologic type ranged from 3...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394743/-a-case-of-duodenum-neuroendocrine-tumor-with-multiple-liver-metastasis-treated-with-multimodal-therapy
#17
Hirotomo Murakami, Naoki Hama, Sakae Maeda, Atsushi Miyamoto, Takuya Hamakawa, Mamoru Uemura, Masakazu Miyake, Kazuhiro Nishikawa, Hideyasu Omiya, Michihiko Miyazaki, Masataka Ikeda, Motohiro Hirao, Koji Takami, Mitsugu Sekimoto, Shoji Nakamori
The patient is a 65-year-old woman with anemia. The multiple liver tumors detected by ultrasonography, it was diagnosed as neuroendocrine tumor(NET), G2 by biopsy. There was an ulcer at the bulb of the duodenum, so we diagnosed liver metastasis of duodenum NET. Because the liver tumors spreaded to both right and left lobes, we carrying out a transcatheter arterial embolization(TAE)twice to liver metastasis, and chemotherapy by octreotide was performed. 20 months after the beginning of treatment, a 4 cm tumor was remained in the left lobe but others were not detected by computed tomography, so we performed cytoreductive surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394701/-experience-of-ramucirumab-plus-folfiri-as-second-line-treatment-for-metastatic-colorectal-cancer-in-our-hospital
#18
Shigeta Hagino, Takashi Miyata, Koya Sakamoto
We experienced 2 cases in which ramucirumab plus FOLFIRI as second-line treatment was beneficial. Case 1 was a 67-yearold man, underwent panitumumab plus mFOLFOX6 as first-line treatment for unresectable rectal cancer with ureteral invasion and multiple liver metastases, but the disease became worse at 9.3 months. We changed to ramucirumab plus FOLFIRI as second-line treatment. After 2 courses, a grade 3 febrile neutropenia was observed, but treatment was beneficial and continued administration for 9 months or more...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393032/-treatment-of-primary-and-recurrent-ovarian-cancer
#19
Mikkel Rosendahl, Berit Jul Mosgaard, Karina Dahl Steffesen
With 550 new cases/year ovarian cancer constitutes 3% of all cancers among women. The unspecific symptoms cause delayed diagnosis and hence poor survival rates. Screening initiatives have been disappointing. In order to accelerate diagnosis and correct surgical management, patients are referred to centralized, specialized units. The primary treatment comprises surgical total cytoreduction followed by platinum-based chemotherapy. Newer biological agents are added when randomized trials have shown a benefit. Recurrence is managed by chemotherapy alone or repeated radical surgery followed by chemotherapy...
January 22, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29388121/techniques-for-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#20
Rebecca M Dodson, Michael Kuncewitch, Konstantinos I Votanopoulos, Perry Shen, Edward A Levine
No abstract text is available yet for this article.
January 31, 2018: Annals of Surgical Oncology
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