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https://www.readbyqxmd.com/read/29739635/cystadenoma-of-the-mandible-a-rare-presentation
#1
H Mahmood, C Murphy, V Oktselglou
To our knowledge this is only the second reported case of a cystadenoma that arose in the mandible. These are rare benign epithelial neoplasms of the salivary gland that comprise 0.8%-6.3% of all minor tumours of the salivary gland. Because cystadenoma of the mandible is so rare, there is little evidence or guidance about management, and enucleation remains the recommended treatment. Careful histological diagnosis is important for differentiation from other morphologically similar salivary gland tumours such as a mucoepidermoid carcinoma...
May 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29715110/human-polyomaviruses-are-not-frequently-present-in-cancer-of-the-salivary-glands
#2
Torbjörn Ramqvist, Ramona Gabriela Ursu, Linnea Haeggblom, Leila Mirzaie, Caroline Gahm, Lalle Hammarstedt-Nordenvall, Tina Dalianis, Anders Näsman
BACKGROUND/AIM: Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor subtypes was examined. MATERIALS AND METHODS: Ninety-one primary tumors, including 12 subtypes and eight corresponding metastases, were analyzed for the presence of DNA of 10 different human PyV species by a bead-based multiplex assay using polymerase chain reaction and Luminex analyses...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29691554/-retrospective-analysis-of-896-cases-of-parotid-gland-tumor
#3
Zhi-Guo Zhao, Dan Gao, Jin Wang, Li-Ping Zhang
PURPOSE: To review the clinical data of patients undergoing operation, in order to summarize the incidence, proportion, clinical examination and diagnostic methods of parotid tumors. METHODS: Eight hundred and ninty-six cases of parotid gland tumors were collected from 2008 January to 2015 July from department of oral and maxillofacial surgery in Shengjing Hospital of China Medical University. A retrospective study of the clinical data was carried out, including age, gender, tumor location, diagnostic methods and pathological results...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29688836/pediatric-salivary-cancer-epidemiology-treatment-trends-and-association-of-treatment-modality-with-survival
#4
Elliot Morse, Rance J T Fujiwara, Zain Husain, Benjamin Judson, Saral Mehra
Objective To characterize the epidemiology of pediatric salivary cancer and associate patient, tumor, and treatment factors with treatment modality and survival. Study Design Cross-sectional analysis. Setting US national database. Subjects and Methods We identified 588 patients 19 years or younger diagnosed with salivary cancer in the National Cancer Database 2004-2013. We characterized patient, tumor, and treatment factors as proportions and associated these factors with treatment modality and overall survival via multivariable logistic regression and multivariable Cox proportional hazards regression, respectively...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29676367/sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-of-thyroid-gland-not-so-indolent-a-neoplasm
#5
Anila Kunjulekshmi Amma Raveendran Nair, Nebu A George, Rejnish Kumar, A Sreekumar, K Jayasree
A 58-year-old female, a known diabetic and hypertensive, presented with left-sided swelling on the anterior aspect of the neck of 1-year duration, which was rapidly increasing in size for the past 6 months. She was on Eltroxin for hypothyroidism for the past 1 year. Computed tomography study of the neck showed a nodule in the left lobe of thyroid which on fine-needle aspiration was suspicious for malignancy. Total thyroidectomy with left posterolateral lymph node dissection was done. Histopathological examination showed sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland with lymph node metastasis...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675367/mucoepidermoid-carcinoma-of-the-trachea
#6
Moh'd Al-Halawani, Yazan Abdeen
No abstract text is available yet for this article.
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#7
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#8
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29658113/has-the-management-of-pediatric-mucoepidermoid-carcinoma-of-the-parotid-gland-changed
#9
Tyler A Janz, P Ryan Camilon, Shaun A Nguyen, Jessica R Levi, Eric J Lentsch
OBJECTIVES/HYPOTHESIS: To examine the evolving changes in management of pediatric mucoepidermoid carcinoma of the parotid gland. STUDY DESIGN: Retrospective analysis of a large population database. METHODS: Pediatric patients in the Surveillance, Epidemiology, and End Results database were included from 1973 to 2014 based on a diagnosis of mucoepidermoid carcinoma of the parotid gland using the International Classification of Diseases for Oncology, Third Edition codes: C07...
April 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29622120/imaging-of-minor-salivary-glands
#10
REVIEW
Ahmed Abdel Khalek Abdel Razek, Suresh K Mukherji
Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. The most common malignant tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, and the most common benign tumor is pleomorphic adenoma. Non-neoplastic lesions may involve minor salivary glands such as Sjogrene disease, immunoglobulin G4-related disease, necrotizing sialometaplasia, and subacute necrotizing sialadenitis...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29608903/the-efficacy-of-touch-smear-cytology-in-the-diagnosis-of-salivary-gland-cancers
#11
Seiji Hosokawa, Satoru Takebayashi, Yutaka Sasaki, Hiroyuki Mineta
PURPOSE: Methods for cytologic diagnosis, such as fine-needle aspiration (FNA) and touch smear (TS) cytology, have been frequently used for malignant tumor screening; however, false-negative cases often result in misdiagnosis. The purpose of this study was to investigate the causes of false-negative cases and methods to decrease the false-negative rate in salivary gland tumor TS cytology. MATERIALS AND METHODS: In this cross-sectional study, the authors examined pathologically confirmed salivary gland tumors in 127 cases in which FNA and TS cytology were performed before the operation or open biopsy at Numazu City Hospital (Numazu, Japan) from 2002 to 2016...
March 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29600360/histopathological-assessment-for-esophageal-adenocarcinoma
#12
Alfred K Lam
In the World Health Organization (WHO) classification, adenocarcinoma of esophagus comprises preinvasive type (dysplasia), adenocarcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, and mucoepidermoid carcinoma. For adenocarcinoma, it is important to determine the grading of the cancer and histological variants such as signet ring adenocarcinoma. In the current day management of esophageal adenocarcinoma by neoadjuvant therapy, the histology of the cancer and the lymph nodal status may change after the therapy...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29575399/unique-application-of-awake-tracheoscopy-and-endobronchial-ultrasound-in-the-management-of-tracheal-mucoepidermoid-carcinoma
#13
Saad Rehman, Harold N Lovvorn, Otis B Rickman, Christopher T Wootten, Sivakumar Chinnadurai
BACKGROUND: Mucoepidermoid carcinoma of the trachea is a rare pediatric malignancy that presents unique challenges in diagnosis, operative management, and surveillance. METHODS AND RESULTS: We present a 17-year-old girl with primary tracheal mucoepidermoid carcinoma presenting in acute respiratory distress due to near-total occlusion of the tracheal airway. An algorithmic approach to preoperative planning was developed to evaluate and remove the tumor endoscopically without compromising oxygenation...
March 25, 2018: Head & Neck
https://www.readbyqxmd.com/read/29559174/mucoepidermoid-carcinoma-of-the-parotid-gland-a-national-cancer-database-study
#14
Karthik Rajasekaran, Vanessa Stubbs, Jinbo Chen, Pratyusha Yalamanchi, Steven Cannady, Jason Brant, Jason Newman
OBJECTIVE: To describe the demographics, tumor characteristics, and prognostic features of mucoepidermoid carcinoma of the parotid gland. MATERIALS AND METHODS: A retrospective study of the National Cancer Database was reviewed for all mucoepidermoid carcinomas of the parotid gland between 2004 and 2012). Patient demographics and tumor characteristics were abstracted and analyzed. Univariate and multivariate Cox multivariate regression models were used to identify predictors of survival...
May 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29555661/salivary-gland-cancer-patient-derived-xenografts-enable-characterization-of-cancer-stem-cells-and-new-gene-events-associated-with-tumor-progression
#15
Stephen B Keysar, Justin R Eagles, Bettina Miller, Brian C Jackson, Farshad N Chowdhury, Julie Reisinger, Tugs-Saikhan Chimed, Phuong N Le, John J Morton, Hilary L Somerset, Marileila Varella-Garcia, Aik-Choon Tan, John I Song, Daniel W Bowles, Mary E Reyland, Antonio Jimeno
Purpose: Salivary gland cancers (SGC) frequently present with distant metastases many years after diagnosis, suggesting a cancer stem cell (CSC) subpopulation that initiates late recurrences; however, current models are limited both in their availability and suitability to characterize these rare cells. Experimental Design: Patient-derived xenografts (PDX) were generated by engrafting patient tissue onto nude mice from one acinic cell carcinoma (AciCC), four adenoid cystic carcinoma (ACC), and three mucoepidermoid carcinoma (MEC) cases, which were derived from successive relapses from the same MEC patient...
March 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29538223/you-cannot-miss-it-pancreatic-mucoepidermoid-carcinoma-a-case-report-and-literature-review
#16
Hai-Jie Hu, Rong-Xing Zhou, Fei Liu, Jun-Ke Wang, Fu-Yu Li
RATIONALE: Pancreatic mucoepidermoid carcinoma (MEC) is a rare disease with no more than 10 cases reported in literature. The prognosis is poor and few patients can survival more than 1 year. PATIENT CONCERNS: We presented a case of patient manifested as left upper abdominal pain. Computed tomography demonstrated a low-density shadow measuring 2.1 × 2.4 cm situated at the transition area of neck and body of the pancreas with obscure boundary and irregular enhancement...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29494398/rank-and-rank-ligand-expression-in-parotid-gland-carcinomas
#17
Alessandro Franchi, Cecilia Taverna, Antonella Simoni, Monica Pepi, Giuditta Mannelli, Martina Fasolati, Oreste Gallo
Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic parameters. Formalin-fixed paraffin-embedded tumor samples from 46 consecutive cases of parotid gland carcinoma were selected for this study. For comparison, we examined a group of 40 randomly chosen parotid gland adenomas, including 20 pleomorphic adenomas, 10 myoepitheliomas, and 10 Warthin tumors...
February 28, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29493851/a-retrospective-multicenter-study-of-carbon-ion-radiotherapy-for-major-salivary-gland-carcinomas-subanalysis-of-j-cros-1402-hn
#18
Kazuhiko Hayashi, Masashi Koto, Yusuke Demizu, Jun-Ichi Saitoh, Hiroaki Suefuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Ryo Takagi, Hiroaki Ikawa, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
A retrospective multicenter study was carried out to assess the clinical outcomes of carbon-ion radiotherapy for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We evaluated the safety and efficacy of carbon-ion radiotherapy in patients with major salivary gland carcinoma. Sixty-nine patients treated with carbon-ion radiotherapy at four Japanese institutions were analyzed. Thirty-three patients (48%) had adenoid cystic carcinomas, 10 (14%) had mucoepidermoid carcinomas, and 26 (38%) had other disease types...
March 1, 2018: Cancer Science
https://www.readbyqxmd.com/read/29492469/genomics-of-mucoepidermoid-and-adenoid-cystic-carcinomas
#19
REVIEW
Kenneth Yan, Jessica Yesensky, Rifat Hasina, Nishant Agrawal
Objective: To report on the current state of the literature on the genetics of mucoepidermoid and adenoid cystic carcinomas of the salivary glands with a focus on genomic screens and recently discovered genetic translocations. Methods: A PubMed based literature review was performed to query for genetics related basic science and preclinical studies about mucoepidermoid and adenoid cystic carcinomas of the salivary glands. Results and conclusions: Genetic translocations between CRTC1 and MAML2 in mucoepidermoid carcinoma and between MYB and NFIB in adenoid cystic carcinoma have been recently discovered and have therapeutic implications...
February 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29491610/keratinizing-pleomorphic-adenoma-an-unusual-case-report
#20
Aanchal Tandon, Rohit Jaiswal, Safia Siddiqui, Bharadwaj Bordoloi
Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we report a case of slowly enlarging PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland in hard palate and discuss its microscopic features...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
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