keyword
MENU ▼
Read by QxMD icon Read
search

Mucoepidermoid carcinoma

keyword
https://www.readbyqxmd.com/read/28438292/correlation-of-crtc1-3-maml2-fusion-status-grade-and-survival-in-mucoepidermoid-carcinoma
#1
Andrew C Birkeland, Susan K Foltin, Nicole L Michmerhuizen, Rebecca C Hoesli, Andrew J Rosko, Serena Byrd, Megan Yanik, Jacques E Nor, Carol R Bradford, Mark E Prince, Thomas E Carey, Jonathan B McHugh, Matthew E Spector, J Chad Brenner
OBJECTIVE: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Tumor stage and grade have historically been important predictors of survival. An oncogenic CRTC1- or CRTC3-MAML2 gene fusion has been identified in a number of MECs. Historically, these gene fusions have been associated with lower grade tumors and better survival. However, reported gene fusion rates and prognosis varies widely across studies, and have not controlled for tumor grade. We sought to identify gene fusion rates and outcomes in our cohort of MEC patients...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28412212/mucoepidermoid-carcinoma-with-extensive-spindled-morphology-and-melanocytic-marker-expression
#2
Takashi Oide, Kenzo Hiroshima, Yoko Takahashi, Kazunori Fugo, Masanobu Yamatoji, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Masashi Shiiba, Katsuhiro Uzawa, Hideki Tanzawa, Toshitaka Nagao, Yukio Nakatani
Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland. Albeit common, histological variants have rarely been noted in MEC. Here, we report a 49-year-old man with a sublingual gland tumor. Histologically, the tumor was composed of spindle cells arranged in interlacing fascicules or globular nests. A few bland small glands containing mucous cells were also scattered. The spindle tumor cells completely lacked immunoreactivity for cytokeratin, and exhibited immunoreactivity for vimentin, S-100, HMB-45, Melan A, and SOX10...
April 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28411376/nodular-oncocytic-hyperplasia-can-cytomorphology-allow-for-the-preoperative-diagnosis-of-a-nonneoplastic-salivary-disease
#3
Lisa M Rooper, Mine Onenerk, Momin T Siddiqui, William C Faquin, Justin A Bishop, Syed Z Ali
BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases...
April 14, 2017: Cancer
https://www.readbyqxmd.com/read/28408701/low-grade-mucoepidermoid-tumor-of-parotid-gland-presenting-as-focal-asymmetry-in-the-follow-up-radioiodine-scan-in-a-patient-of-differentiated-papillary-carcinoma-of-thyroid
#4
Chinna Naik, Sandip Basu
Low grade mucoepidermoid tumor of the right parotid gland presenting as focal uptake in the follow-up whole body iodine scan in a patient of differentiated papillary carcinoma of thyroid 1 year after successful ablation is presented in this report. Following surgical excision, the histopathology was proven. The illustrated case represents false positive focal accumulation of (131)I in low grade mucoepidermoid carcinoma of the salivary gland that arose early in the follow-up course in differentiated thyroid carcinoma post-radioiodine (RAI)...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28401485/silymarin-and-its-active-component-silibinin-act-as-novel-therapeutic-alternatives-for-salivary-gland-cancer-by-targeting-the-erk1-2-bim-signaling-cascade
#5
Eun-Sun Choi, Sejun Oh, Boonsil Jang, Hyun-Ju Yu, Ji-Ae Shin, Nam-Pyo Cho, In-Hyoung Yang, Dong-Hoon Won, Hye-Jeong Kwon, Seong Doo Hong, Sung-Dae Cho
PURPOSE: Approximately 20% of all salivary gland cancer patients who are treated with current treatment modalities will ultimately develop metastases. Its most common form, mucoepidermoid carcinoma (MEC) is a highly aggressive tumor with an overall 5-year survival rate of ~30%. Until now, several chemotherapeutic drugs have been tested for the treatment of salivary gland tumors, but the results have been disappointing and the drugs often cause unwanted side effects. Therefore, several recent studies have focused on the potential of alternative and/or complementary therapeutic options, including the use of silymarin...
April 11, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28397345/primary-mucoepidermoid-carcinoma-of-the-breast
#6
Santiago Sherwell-Cabello, Antonio Maffuz-Aziz, Nina Paola Ríos-Luna, Mariela Pozo-Romero, Patricia Verónica López-Jiménez, Sergio Rodriguez-Cuevas
No abstract text is available yet for this article.
April 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28388900/surface-enhanced-raman-spectroscopy-of-blood-serum-based-on-gold-nanoparticles-for-the-diagnosis-of-the-oral-squamous-cell-carcinoma
#7
Yingyun Tan, Bing Yan, Lili Xue, Yi Li, Xianyang Luo, Ping Ji
BACKGROUND: Oral squamous cell carcinoma (OSCC) is becoming more common across the globe. The prognosis of OSCC is largely dependent on the early detection. But the routine oral cavity examination may delay the diagnosis because the early oral malignant lesions may be clinically indistinguishable from benign or inflammatory diseases. In this study, the new diagnostic method is developed by using the surface enhanced Raman spectroscopy (SERS) to detect the serum samples from the cancer patients...
April 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28383603/mucoepidermoid-carcinoma-of-the-salivary-glands-a-retrospective-study-of-51-cases-and-review-of-the-literature
#8
Janet O Guevara-Canales, Rafael Morales-Vadillo, Guillermo Guzmán-Arias, Carlos E Cava-Vergiú, Henry Guerra-Miller, Jaime E Montes-Gil
The aim of this study is to present the casuistic of mucoepidermoid carcinoma of salivary glands in patients diagnosed at "Dr. Eduardo Cáceres Graziani" National Institute for Neoplastic Diseases, Lima, Perú. From January 2002 to December 2012, 51 cases were diagnosed as mucoepidermoid carcinoma. The number of female patients was higher, with 28 cases (54.9%), and regarding age distribution, 33.3% of the patients were under 30 years old. Pain was one of the main symptoms, and 74.5% of the mucoepidermoid carcinomas were located in the parotid gland...
December 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28356700/indolent-palatal-swelling-catch-22
#9
Preeti Sharma, Vijay Wadhwan, K V Arun Kumar, Arvind Venkatesh, Timsy Thapa
We present an interesting but intriguing case of an indolent palatal swelling. The lesion was asymptomatic causing little discomfort to the patient and thus was an incidental clinical finding. Provisional diagnosis was a benign, minor salivary gland tumor. Clinical differential diagnoses included benign lymphoepithelial lesion or mucus extravasation phenomenon. Nevertheless, we also considered malignancies such as mucoepidermoid carcinoma, lymphoma, and neoplasm of the maxillary sinus. However, the histopathology revealed a rare clinicopathologic entity prompting immediate treatment of the lesion...
July 2016: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28351791/a-rare-cause-of-duodenal-obstruction-metastatic-parotid-mucoepidermoid-carcinoma
#10
Dominique Kasindi, Rajeev Jain
No abstract text is available yet for this article.
March 25, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28347886/immunohistochemical-expression-of-epithelial-cell-adhesion-molecule-epcam-in-mucoepidermoid-carcinoma-compared-to-normal-salivary-gland-tissues
#11
Noura M Kamal, Hend M Salem, Heba M Dahmoush
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor which displays biological, histological and clinical diversity thus representing a challenge for its diagnosis and management. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein identified as a tumor specific antigen due to its frequent overexpression in the majority of epithelial carcinomas and its correlation with prognosis. It is considered to be a promising biomarker used as a therapeutic target already in ongoing clinical trials...
March 21, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28346650/submandibular-salivary-gland-tumors-clinical-course-and-outcome-of-a-20-year-multicenter-study
#12
Aviram Mizrachi, Gideon Bachar, Yaron Unger, Ohad Hilly, Dan M Fliss, Thomas Shpitzer
The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. One hundred ninety-three patients were identified, of whom 108 (56%) had non-neoplastic disorders (sialolithiasis and sialadenitis)...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28343305/clinicopathologic-and-genetic-features-of-primary-bronchopulmonary-mucoepidermoid-carcinoma-the-md-anderson-cancer-center-experience-and-comprehensive-review-of-the-literature
#13
Alireza Salem, Diana Bell, Boris Sepesi, Vassiliki Papadimitrakopoulou, Adel El-Naggar, Cesar A Moran, Neda Kalhor
Primary bronchopulmonary mucoepidermoid carcinoma (BPMEC) is a rare tumor. The fusion protein MECT1-MAML2 has been implicated as a causative genetic event in salivary and BPMECs. Several studies have shown the impact of MECT1-MAML2 on the diagnosis and prognosis of salivary gland mucoepidermoid carcinoma; however, few studies have been published regarding MECT1-MAML2 in the context of primary BPMEC. We describe the clinicopathologic, genetic, and outcome data of 16 patients with BPMEC. Clinicopathologic features were recorded from the electronic medical records...
March 25, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28337465/inflammatory-response-and-barrier-dysfunction-by-different-e-cigarette-flavoring-chemicals-identified-by-gas-chromatography-mass-spectrometry-in-e-liquids-and-e-vapors-on-human-lung-epithelial-cells-and-fibroblasts
#14
Janice Gerloff, Isaac K Sundar, Robert Freter, Emily R Sekera, Alan E Friedman, Risa Robinson, Todd Pagano, Irfan Rahman
Recent studies suggest that electronic cigarette (e-cig) flavors can be harmful to lung tissue by imposing oxidative stress and inflammatory responses. The potential inflammatory response by lung epithelial cells and fibroblasts exposed to e-cig flavoring chemicals in addition to other risk-anticipated flavor enhancers inhaled by e-cig users is not known. The goal of this study was to evaluate the release of the proinflammatory cytokine (interleukin-8 [IL-8]) and epithelial barrier function in response to different e-cig flavoring chemicals identified in various e-cig e-liquid flavorings and vapors by chemical characterization using gas chromatography-mass spectrometry analysis...
March 1, 2017: Applied in Vitro Toxicology
https://www.readbyqxmd.com/read/28332304/sclerosing-polycystic-adenosis-a-rare-tumor-misdiagnosed-as-retention-cyst-on-fine-needle-aspiration-cytology
#15
Shilpi, Fuzail Ahmad Ansari, Shalini Bahadur, Akshi Katyal, Aastha Narula, Namrata Nargotra, Sompal Singh
Sclerosing polycystic adenosis (SPA) is a rare benign neoplasm of the salivary gland which resembles the fibrocystic disease of the breast clinically as well as morphologically. This entity has varied morphological presentation on fine needle aspiration. Only a few case reports and occasional case series are found in the literature describing its cytology. Here we are presenting a case of SPA in the parotid gland in a 13-year-old male patient who presented with a slow growing infra-auricular mass since one year without any other symptoms...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28330594/sclerosing-mucoepidermoid-carcinoma-of-the-sublingual-gland
#16
D H Lee, J H Kim, J K Lee, S C Lim
INTRODUCTION: Sclerosing mucoepidermoid carcinoma of the salivary gland is a rare subtype of mucoepidermoid carcinoma. The most common site of sclerosing mucoepidermoid carcinoma of the salivary glands is the parotid gland, followed by the submandibular gland, and the minor salivary glands. OBSERVATION: Here we report the first case of sclerosing mucoepidermoid carcinoma of the sublingual gland. DISCUSSION: Clinicians should consider sclerosing mucoepidermoid carcinoma in the differential diagnosis of salivary gland neoplasm...
March 16, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28327999/comprehensive-genomic-profiling-of-salivary-mucoepidermoid-carcinomas-reveals-frequent-bap1-pik3ca-and-other-actionable-genomic-alterations
#17
K Wang, J D McDermott, A B Schrock, J A Elvin, L Gay, S D Karam, D Raben, H Somerset, S M Ali, J S Ross, D W Bowles
Background: We sought to identify genomic alterations (GAs) in salivary mucoepidermoid carcinomas. Patients and methods: DNA was extracted from 48 mucoepidermoid carcinomas. Comprehensive genomic profiling (CGP) including the calculation to tumor mutational burden (TMB) was performed on hybridization-captured adaptor ligation-based libraries of 315 cancer-related genes plus introns from 28 genes frequently rearranged for cancer and evaluated for all classes of GAs...
April 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28302219/-mucoepidermoid-carcinoma-of-the-lung-report-of-29-cases
#18
Jingjing Hou, Huijuan Wang, Guowei Zhang, Yanyang Huang, Zhiyong Ma
BACKGROUND: Pulmonary mucoepidermoid carcinoma (MEC) is an extremely rare pulmonary malignant tumor, its clinical features and conditions of prognosis is not entirely clear. The aim of this study is to discuss clinical features, diagnostic and therapeutic methods, and prognosis of pulmonary MEC. METHODS: We retrospectively studied 29 pulmonary MEC patients who diagnosed from January 2006 to December 2015 in Affiliated Hospital of Zhengzhou University. The clinical features, prognosis, diagnostic and therapeutic methods were analyzed...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28299426/immunoexpression-of-glut-1-and-angiogenic-index-in-pleomorphic-adenomas-adenoid-cystic-carcinomas-and-mucoepidermoid-carcinomas-of-the-salivary-glands
#19
Lélia Batista de Souza, Lucileide Castro de Oliveira, Cassiano Francisco Weege Nonaka, Maria Luiza Diniz de Sousa Lopes, Leão Pereira Pinto, Lélia Maria Guedes Queiroz
This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody...
March 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28292512/clinicopathological-and-multisection-ct-features-of-primary-pulmonary-mucoepidermoid-carcinoma
#20
D-L Cheng, Y-X Hu, P-Q Hu, G Wen, K Liu
AIM: To delineate the multisection computed tomography (MSCT) features and the clinical characteristics of primary pulmonary mucoepidermoid carcinoma (PMEC). Prognostic factors were also analysed. MATERIALS AND METHODS: A retrospective study was undertaken to investigate the medical records and MSCT performance of histopathologically confirmed PMECs from 2007 to 2015. RESULTS: A total of 83.3% of patients with high-grade PMECs were aged >40 years, whereas there were 1...
March 11, 2017: Clinical Radiology
keyword
keyword
25953
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"