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https://www.readbyqxmd.com/read/29165364/the-rosiglitazone-like-effects-of-vitexilactone-a-constituent-from-vitex-trifolia-l-in-3t3-l1-preadipocytes
#1
Atsuyoshi Nishina, Masaya Itagaki, Daisuke Sato, Hirokazu Kimura, Yasuaki Hirai, Nyunt Phay, Makoto Makishima
The increased number of patients with type 2 diabetes (T2D) has become a worldwide problem, and insulin sensitizers such as thiazolidinediones (TZDs) are used as therapeutic agents. We found that extracts of Vitex trifolia L. (V. trifolia), a medicinal plant from Myanmar, induced adipogenesis similar to rosiglitazone (ROS), which is a TZD, in 3T3-L1 preadipocytes. In the present study, we attempted to isolate from V. trifolia those compounds that showed ROS-like effects. Among the extracts of hexane, ethyl acetate, and methanol obtained from V...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29043349/comparative-suppressing-effects-of-black-and-green-teas-on-the-formation-of-advanced-glycation-end-products-ages-and-age-induced-oxidative-stress
#2
P Ramlagan, P Rondeau, C Planesse, V S Neergheen-Bhujun, E Bourdon, T Bahorun
This study aimed at investigating and comparing the anti-diabetic potential of black and green teas. Biochemical analyses indicate higher antioxidant potency, significantly correlated with the phytochemicals present, in green teas compared to black teas. Both extracts afforded a similar level of protection to erythrocytes against peroxyl radical-induced lysis. Non-cytotoxic concentration of green and black tea extracts significantly reduced the reactive oxygen species (ROS) production (P < 0.01), lowered the oxidation of proteins (P < 0...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/28966078/change-in-circulating-microrna-profile-of-obese-children-indicates-future-risk-of-adult-diabetes
#3
Xianwei Cui, Lianghui You, Lijun Zhu, Xing Wang, Yahui Zhou, Yun Li, Juan Wen, Yankai Xia, Xinru Wang, Chenbo Ji, Xirong Guo
PURPOSE: Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic biomarkers, and they may contribute to the progression toward T2D. Here, we investigated the possibility of predicting the future risk of adult T2D in obese children by using circulating miRNAs. BASIC PROCEDURES: We performed miRNA high-throughput sequencing to screen relevant circulating miRNAs in obese children...
September 28, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28950392/systemic-hypoxia-increases-the-expression-of-dpp4-in-preadipocytes-of-healthy-human-participants
#4
Helena H Chowdhury, Jelena Velebit, Igor B Mekjavic, Ola Eiken, Marko Kreft, Robert Zorec
Dipeptidyl peptidase 4 (DPP4) is a transmembrane glycoprotein involved in protein degradation. Due to its action on incretins, which increase insulin secretion, DPP4 is considered a therapeutic target for type 2 diabetes. Here we have studied the role of single and combined effects of hypoxia and inactivity on the expression of DPP4 in human adipose tissue of 12 adult normal-weight males. Fat biopsies were obtained at baseline and after each of three experimental campaigns. The results revealed that in isolated human preadipocytes the expression of DPP4 was significantly increased by exposure of participants to hypoxia...
September 26, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28920418/myogenic-satellite-cells-differentiation-with-linolenic-and-retinoic-and-thiazolidenediones-from-prepubertal-korean-black-goat
#5
Sugathan Subi, Sungjin Lee, Supriya Shiwani, Naresh Kumar Singh
Objective: Myogenic satellite cells were isolated from semitendinosus muscle of prepubertal Korean black goat to observe the differential effect of linolenic and retinoic acid in thepresence of thiazolidinediones and also to observe the production insulin sensitive preadipocyte. Methods: Cells were characterized for its stemness with CD 34, CD 13, CD 106, CD44, Vimentin surface markers using flow cytometry. Cells characterized themselves to possess significant (p<0...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28901460/tumor-necrosis-factor%C3%A2-%C3%AE-and-interleukin%C3%A2-6-suppress-microrna%C3%A2-1275-transcription-in-human-adipocytes-through-nuclear-factor%C3%A2-%C3%AE%C2%BAb
#6
Yu-Feng Zhou, Zi-Yi Fu, Xiao-Hui Chen, Yan Cui, Chen-Bo Ji, Xi-Rong Guo
Obesity is a confirmed risk factor for hyperlipidemia, type‑II diabetes, hypertension, and cardiovascular disease. MicroRNAs (miRs) have emerged as an important field of study within energy metabolism and obesity. A previous study demonstrated miR‑1275 to be markedly down‑regulated during maturation of human preadipocytes. It has been reported that miR‑1275 dysregulates expression in several types of cancer and infections. Little is currently known about the regulation of miR‑1275 transcription. The aim of the current study was to explore the mechanism underlying the expression of miR‑1275 in mature human adipocytes...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28868898/the-tumour-suppressor-cdkn2a-p16-ink4a-regulates-adipogenesis-and-bone-marrow-dependent-development-of-perivascular-adipose-tissue
#7
Kristiaan Wouters, Yann Deleye, Sarah A Hannou, Jonathan Vanhoutte, Xavier Maréchal, Augustin Coisne, Madjid Tagzirt, Bruno Derudas, Emmanuel Bouchaert, Christian Duhem, Emmanuelle Vallez, Casper G Schalkwijk, François Pattou, David Montaigne, Bart Staels, Réjane Paumelle
The genomic CDKN2A/B locus, encoding p16(INK4a) among others, is linked to an increased risk for cardiovascular disease and type 2 diabetes. Obesity is a risk factor for both cardiovascular disease and type 2 diabetes. p16(INK4a) is a cell cycle regulator and tumour suppressor. Whether it plays a role in adipose tissue formation is unknown. p16(INK4a) knock-down in 3T3/L1 preadipocytes or p16(INK4a) deficiency in mouse embryonic fibroblasts enhanced adipogenesis, suggesting a role for p16(INK4a) in adipose tissue formation...
November 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28822994/glucagon-like-peptide-1-receptor-agonist-stimulates-mitochondrial-bioenergetics-in-human-adipocytes
#8
Joanna Góralska, Agnieszka Śliwa, Anna Gruca, Urszula Raźny, Monika Chojnacka, Anna Polus, Bogdan Solnica, Małgorzata Malczewska-Malec
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are relatively new pharmacological agents used to normalize glucose level in type 2 diabetes. Recently, GLP-1RAs have been approved for the treatment of obesity to reduce body weight in non-diabetic patients. The extra-pancre-atic effects of GLP-1RAs, as well as their molecular mechanism of action, are still poorly understood. Thus this study was aimed to verify the hypothesis that the mechanism of action of the GLP-1RAs involves mitochondria and that GLP-1RAs administration can improve mitochondrial functions...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28808402/role-of-adiantum-philippense-l-on-glucose-uptake-in-isolated-pancreatic-cells-and-inhibition-of-adipocyte-differentiation-in-3t3-l1-cell-line
#9
Tania Paul, Kishori G Apte, Pradeep B Parab, Biswadeep Das
BACKGROUND: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. OBJECTIVE: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28747725/echinomycin-inhibits-adipogenesis-in-3t3-l1-cells-in-a-hif-independent-manner
#10
Junna Yamaguchi, Tetsuhiro Tanaka, Hisako Saito, Seitaro Nomura, Hiroyuki Aburatani, Hironori Waki, Takashi Kadowaki, Masaomi Nangaku
Obesity is a risk factor for many diseases including diabetes, cancer, cardiovascular disease, and chronic kidney disease. Obesity is characterized by the expansion of white adipose tissue (WAT). Hypertrophy and hyperplasia of adipocytes cause tissue hypoxia followed by inflammation and fibrosis. Its trigger, preadipocyte differentiation into mature adipocytes, is finely regulated by transcription factors, signal molecules, and cofactors. We found that echinomycin, a potent HIF-1 inhibitor, completely inhibited adipogenesis in 3T3-L1 WAT preadipocytes by affecting the early phase of mitotic clonal expansion...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716822/dock2-deficiency-mitigates-hfd-induced-obesity-by-reducing-adipose-tissue-inflammation-and-increasing-energy-expenditure
#11
Xia Guo, Feifei Li, Zaiyan Xu, Amelia Yin, Hang Yin, Chenxiao Li, Shi-You Chen
Obesity is the major risk factor for type 2 diabetes, cardiovascular disorders, and many other diseases. Adipose tissue inflammation is frequently associated with obesity and contributes to the morbidity and mortality. Dedicator of cytokinesis 2 (DOCK2) is involved in several inflammatory diseases, but its role in obesity remains unknown. To explore the function of DOCK2 in obesity and insulin resistance, WT and DOCK2-deficient (DOCK2(-/-)) mice were given chow or high-fat diet (HFD) for 12 weeks followed by metabolic, biochemical, and histologic analyses...
September 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28699004/a-delayed-proinflammatory-response-of-human-preadipocytes-to-pcb126-is-dependent-on-the-aryl-hydrocarbon-receptor
#12
Francoise A Gourronc, Larry W Robertson, Aloysius J Klingelhutz
Inflammation in adipose tissue is recognized as a causative factor in the development of type II diabetes. Adipocyte hypertrophy as well as bacterial and environmental factors have been implicated in causing inflammation in mature adipocytes. Exposure to persistent organic pollutants such as polychlorinated biphenyls (PCBs) has been associated with the development of type II diabetes. We show here that PCB126, a dioxin-like PCB, activates a robust proinflammatory state in fat cell precursors (preadipocytes)...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28607454/insulin-sparing-and-fungible-effects-of-e4orf1-combined-with-an-adipocyte-targeting-sequence-in-mouse-models-of-type-1-and-type-2-diabetes
#13
I-S Yoon, S Park, R-H Kim, H L Ko, J-H Nam
Obesity impairs glycemic control and causes insulin resistance and type 2 diabetes. Adenovirus 36 (Ad36) infection can increase the uptake of excess glucose from blood into adipocytes by increasing GLUT4 translocation through the Ras-Akt signaling pathway, which bypasses PI3K-Akt-mediated insulin receptor signaling. E4orf1, a viral gene expressed early during Ad36 infection, is responsible for this insulin-sparing effect and may be an alternative target for improving insulin resistance. To deliver the gene to adipocytes only, we connected the adipocyte-targeting sequence (ATS) to the 5' end of E4orf1 (ATS-E4orf1)...
October 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28543688/glycated-human-albumin-alters-mitochondrial-respiration-in-preadipocyte-3t3-l1-cells
#14
Pascal Baret, Fanny Le Sage, Cynthia Planesse, Olivier Meilhac, Anne Devin, Emmanuel Bourdon, Philippe Rondeau
Diabetes and obesity are strongly associated with increased levels of circulating advanced glycation end products (AGEs) and reactive oxygen species (ROS). These two molecular phenomena affect the physiology of adipose tissue, a biological driver of the metabolic syndrome, leading to an inflammatory profile and insulin resistance, which could contribute to obesity/diabetes-associated complications, such as cardiovascular diseases. Herein, we investigated the impact of AGEs on mitochondrial bioenergetics in murine preadipocyte cells (3T3-L1) and cellular redox homeostasis...
May 22, 2017: BioFactors
https://www.readbyqxmd.com/read/28539724/anti-differentiation-effect-of-b-d-seco-limonoids-of-swietenia-mahogani
#15
Heejung Yang, Mina Choi, Dong Young Lee, Sang Hyun Sung
BACKGROUND: Obesity is a pathological state caused by abnormal or excessive accumulation of fat. Swietenia mahogani JACQ., known as West Indian mahogany, is a medium-sized semi-evergreen tree belonging to Meliaceae. Their seeds are used in Indonesian folk medicine as a treatment for hypertension, diabetes, malaria, and it also has anti-feedant activities. The major components of S. mahogani are B, D-seco limonoids, a type of irregular triterpenes are well known. OBJECTIVE: We tried to find the bioactive components, which have the inhibitory activity on adipocyte differentiation from the seeds of S...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28526415/lnk-deficiency-aggravates-palmitate-induced-preadipocyte-apoptosis
#16
Jie-Yi Du, Chen-Chen Jin, Guo-Hao Wang, Xiong-Qing Huang, Jian-Ding Cheng, Xue-Jun Wen, Xiao-Miao Zhao, Guan-Lei Wang
LNK (SH2B3) is an intracellular adaptor protein that negatively regulates cellular proliferation or self-renewal of hematopoietic stem cells and some other progenitor cells. LNK is also recognized as a key regulator of insulin resistance and inflammatory responses in several tissues and organs. The function of LNK in adipose tissue is unknown. We previously demonstrated that type 2 diabetes mellitus (T2DM) mouse model had elevated serum free fatty acids (FFAs) levels and increased preadipocyte apoptosis in visceral fat tissue, showing the occurrence of lipotoxicity...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28515350/fam3a-enhances-adipogenesis-of-3t3-l1-preadipocytes-via-activation-of-atp-p2-receptor-akt-signaling-pathway
#17
Yujing Chi, Jing Li, Na Li, Zhenzhen Chen, Liping Ma, Weikang Peng, Xiuying Pan, Mei Li, Weidong Yu, Xiangjun He, Bin Geng, Qinghua Cui, Yulan Liu, Jichun Yang
FAM3A plays important roles in regulating hepatic glucose/lipid metabolism and the proliferation of VSMCs. This study determined the role and mechanism of FAM3A in the adipogenesis of 3T3-L1 preadipocytes. During the adipogenesis of 3T3-L1 preadipocytes, FAM3A expression was significantly increased. FAM3A overexpression enhanced 3T3-L1 preadipocyte adipogenesis with increased phosphorylated Akt (pAkt) level, whereas FAM3A silencing inhibited 3T3-L1 preadipocyte adipogenesis with reduced pAkt level. Moreover, FAM3A silencing reduced the expression and secretion of adipokines in 3T3-L1 cells...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28469146/optical-visualisation-of-thermogenesis-in-stimulated-single-cell-brown-adipocytes
#18
Rókus Kriszt, Satoshi Arai, Hideki Itoh, Michelle H Lee, Anna G Goralczyk, Xiu Min Ang, Aaron M Cypess, Andrew P White, Farnaz Shamsi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou, Tetsuya Kitaguchi, Thankiah Sudhaharan, Shin'ichi Ishiwata, E Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng, Madoka Suzuki, Michael Raghunath
The identification of brown adipose deposits in adults has led to significant interest in targeting this metabolically active tissue for treatment of obesity and diabetes. Improved methods for the direct measurement of heat production as the signature function of brown adipocytes (BAs), particularly at the single cell level, would be of substantial benefit to these ongoing efforts. Here, we report the first application of a small molecule-type thermosensitive fluorescent dye, ERthermAC, to monitor thermogenesis in BAs derived from murine brown fat precursors and in human brown fat cells differentiated from human neck brown preadipocytes...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28466023/adipose-tissue-specialized-immunologic-features-might-be-the-potential-therapeutic-target-of-prospective-medicines-for-obesity
#19
REVIEW
Fan Yao, Ming Zhang, Li Chen
Excessive lipid accumulation in adipose tissue is either the source of obesity or the cause and result of chronic local inflammation, and recent studies indicate that the accumulation may induce many other specialized immunologic features with macrophages and epidemic diseases. We analyze the effective stages of immune cells in adipose tissue, including macrophage recruitment, macrophage polarization, and macrophage-like phenotype preadipocyte possession to find optimal sites as drug targets. Subsequently, some main signaling pathways are summarized in this review, including the AMP-activated protein kinase (AMPK) pathway, the JNK signaling pathway, and a novel one, the Notch signaling pathway...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28425841/adipocyte-hypertrophy-hyperplasia-balance-contributes-to-weight-loss-after-bariatric-surgery
#20
Lindsey A Muir, Nicki A Baker, Alexandra R Washabaugh, Christopher K Neeley, Carmen G Flesher, Jennifer B DelProposto, Lynn M Geletka, Amir A Ghaferi, Jonathan F Finks, Kanakadurga Singer, Oliver A Varban, Carey N Lumeng, Robert W O'Rourke
Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cytometry, immunohistochemistry, and QRTPCR, and results correlated with weight loss outcomes. Age, male sex, and a diagnosis of type 2 diabetes were associated with less weight loss. Adipocyte size was increased and preadipocyte frequency was decreased in visceral adipose tissue from diabetic subjects...
April 3, 2017: Adipocyte
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