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https://www.readbyqxmd.com/read/28643904/pth-1-34-induced-alterations-predispose-the-mandibular-condylar-cartilage-to-mineralization
#1
E H Dutra, M H O'Brien, T Gutierrez, A Lima, R Nanda, S Yadav
OBJECTIVE: To study the effects of intermittent parathyroid hormone (PTH [1-34]) on the mandibular condylar cartilage (MCC) and subchondral bone in adult female mice. MATERIALS AND METHODS: Twenty-two, 20-week-old female mice were used for in vivo experiments. The experimental mice (n=11) received daily intraperitoneal injections of PTH [1-34] for 3 weeks, while control mice (n=11) received intraperitoneal injections of 0.9% saline solution. Mice were euthanized and then micro-computed tomography (micro-CT); histology and immunostaining were carried out to assess the response...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643272/prevalence-and-risk-factors-for-low-bone-mineral-density-in-ulcerative-colitis
#2
Ram Pratap Singh Bundela, Prachis Ashdhir, Kumar Shwetanshu Narayan, Mukesh Jain, Rupesh Kumar Pokharna, Sandeep Nijhawan
BACKGROUND: Inflammatory bowel disease (IBD) has been associated with increased risk of osteopenia and osteoporosis. Several risk factors contribute to this; however, studies evaluating their association have conflicting results. METHODS: We conducted a cross-sectional study with prospective enrollment of adult ulcerative colitis patients attending the Gastroenterology Department of Sawai Man Singh Hospital, Jaipur Rajasthan between June 2015 and December 2015. Demographic data including age, gender, body mass index (BMI), disease duration, type of disease, prior steroid use and vitamin D levels were recorded and compared with bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA)...
June 23, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28643220/denosumab-an-emerging-therapy-in-pediatric-bone-disorders
#3
REVIEW
Alison M Boyce
PURPOSE OF REVIEW: Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS: Considerable safety and efficacy data exists for denosumab treatment of adults with osteoporosis, bone metastases, and giant cell tumors. Pediatric data is limited; however, evidence suggests denosumab may be beneficial in decreasing bone turnover, increasing bone density, and preventing growth of certain skeletal neoplasms in children...
June 22, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28642974/abdominal-aortic-calcification-and-the-risk-of-bone-fractures-a-meta-analysis-of-prospective-cohort-studies
#4
Dailin Wei, Guanlin Zheng, Yun Gao, Jinying Guo, Tie Zhang
The relationship between abdominal aortic calcification (AAC) and bone fracture has been examined by some observational studies, but the results remain discordant. Therefore, we aimed to assess the link between them by conducting a meta-analysis of prospective studies. Relevant studies were identified by searching PubMed and EMBASE databases until the end of December 2016. Summary relative risks (RRs) and 95% confidence intervals (CIs) for associations between AAC and fracture risk were estimated with fixed- or random- effects models...
June 22, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28642856/longitudinal-change-in-trabecular-bone-score-during-and-after-treatment-of-osteoporosis-in-postmenopausal-korean-women
#5
Mi-Seon Shin, Eun-Hee Cho, Ha Young Kim
BACKGROUND: The aim of this study was to evaluate the longitudinal changes of trabecular bone score (TBS) during and after bisphosphonate (BP) treatment in postmenopausal Korean women with osteoporosis. METHODS: We analyzed 191 patients who took BP and underwent bone mineral density (BMD) test for the period from January 2010 to December 2015. The mean follow up period during treatment and after treatment was 22.8 months and 18 months, respectively. The TBS and BMD values were evaluated by the percent changes relative to the baseline...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642854/measurement-uncertainty-in-spine-bone-mineral-density-by-dual-energy-x-ray-absorptiometry
#6
Ae-Ja Park, Jun-Il Yoo, Jee-Hye Choi, Kyun Shik Chae, Chang Geun Kim, Dal Sik Kim
BACKGROUND: The purpose of this study was to calculate the measurement uncertainty of the process of bone mineral density (BMD) analysis using dual energy X-ray absorptiometry with traceability. METHODS: Between March 2015 and October 2016, among healthy participants in their 20s and 30s, the study included those who had not taken calcium, vitamin D supplements and steroids and were without a history of osteoporosis, osteopenia and diseases related to osteoporosis...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642852/fracture-preventing-effects-of-maxmarvil%C3%A2-tablets-alendronate-5-mg-calcitriol-0-5-%C3%A2%C2%B5g-in-patients-with-osteoporosis
#7
Jun-Il Yoo, Yong-Chan Ha, Ye-Yeon Won, Kyu-Hyun Yang, Sang-Bum Kim, Ju-Hyung Yoo, Dong-Soo Kim
BACKGROUND: The purpose of this prospective, open-label, observational study was to assess the fracture preventing effect of Maxmarvil® tablets (alendronate 5 mg + calcitriol 0.5 µg) in patients with osteoporosis and to evaluate the change in bone mineral density (BMD) at the minimum 1-year follow-up. METHODS: In this multicenter observational study, 691 patients with osteoporosis (aged 50 years or older) were treated with alendronate 5 mg + calcitriol 0.5 µg/day during their normal course of care...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642655/the-influence-of-passive-tobacco-exposure-and-physical-exercise-on-bone-tissue-of-young-rats
#8
Regina Celi Trindade Camargo, Regiane Rocha Costalonga, Mário Jefferson Quirino Louzada, Rômulo Araújo Fernandes, José Carlos Silva Camargo, Jacqueline Bexiga Urban
OBJECTIVE: The objective of this study is to investigate the effect of passive smoking during pregnancy and associated with swimming on bone area growth, bone mineral density (BMD), and bone mineral content (BMC). METHODS: The offspring was grouped by control matrices (G1) and passive smokers (G2). The offspring was regrouped in eight subgroups, with exposure to smoking (2x/day) and physical exercise (1 session/day), respecting the group of matrices in: sedentary control (G1CS and G2CS), swimming control (G1CN and G2CN), sedentary passive smoker (G1FS and G2FS), and passive smoker swimmer (G1FN and G2FN)...
March 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642237/mediator-1-is-atherosclerosis-protective-by-regulating-macrophage-polarization
#9
Liang Bai, Zhao Li, Qianwei Li, Hua Guan, Sihai Zhao, Ruihan Liu, Rong Wang, Jin Zhang, Yuzhi Jia, Jianglin Fan, Nanping Wang, Janardan K Reddy, John Y-J Shyy, Enqi Liu
OBJECTIVE: MED1 (mediator 1) interacts with transcription factors to regulate transcriptional machinery. The role of MED1 in macrophage biology and the relevant disease state remains to be investigated. APPROACH AND RESULTS: To study the molecular mechanism by which MED1 regulates the M1/M2 phenotype switch of macrophage and the effect on atherosclerosis, we generated MED1/apolipoprotein E (ApoE) double-deficient (MED1(ΔMac)/ApoE(-)(/-)) mice and found that atherosclerosis was greater in MED1(ΔMac)/ApoE(-/-) mice than in MED1(fl/fl)/ApoE(-/-) littermates...
June 22, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28642196/gdf5-significantly-augments-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#10
Matthias Bungartz, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Francesca Gunnella, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann
BACKGROUND CONTEXT: Biodegradable calcium phosphate cement (CPC) represents a promising option for the surgical treatment of osteoporotic vertebral fractures. Due to augmented local bone catabolism, however, additional targeted delivery of bone morphogenetic proteins with the CPC may be needed to promote rapid and complete bone regeneration. PURPOSE: In the present study, an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing the bone morphogenetic protein GDF5 was tested in a sheep lumbar osteopenia model...
June 19, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28642011/comparison-of-indian-council-for-medical-research-and-lunar-databases-for-categorization-of-male-bone-mineral-density
#11
Surya K Singh, Vivek Patel, Balram Gupta
The mainstay of diagnosis of osteoporosis is dual-energy X-ray absorptiometry (DXA) scan measuring areal bone mineral density (BMD) (g/cm(2)). The aim of the present study was to compare the Indian Council of Medical Research database (ICMRD) and the Lunar ethnic reference database of DXA scans in the diagnosis of osteoporosis in male patients. In this retrospective study, all male patients who underwent a DXA scan were included. The areal BMD (g/cm(2)) was measured at either the lumbar spine (L1-L4) or the total hip using the Lunar DXA machine (software version 8...
June 19, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28641972/equal-primary-fixation-of-resurfacing-stem-but-inferior-cup-fixation%C3%A2-with-anterolateral-vs-posterior-surgical-approach-a-2-year-blinded-randomized-radiostereometric-and-dual-energy-x-ray-absorptiometry-study-of-metal-on-metal-hip-resurfacing-arthroplasty
#12
Mette H Hjorth, Nina D Lorenzen, Kjeld Søballe, Stig S Jakobsen, Maiken Stilling
BACKGROUND: The anterolateral (AntLat) surgical approach may spare the blood supply to the femoral head and improve the accuracy of cup positioning in metal-on-metal hip resurfacing arthroplasty. Thereby, potentially lessen complications such as avascular head necrosis, femoral neck narrowing and fracture, improve implant fixation, and lessen periprosthetic bone mineral density (BMD) loss. METHODS: Between November 2008 and January 2012, a randomized clinical trial was performed at Aarhus University Hospital...
May 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28640843/metabolic-milieu-associates-with-impaired-skeletal-characteristics-in-obesity
#13
Heli T Viljakainen, Heikki A Koistinen, Taina Tervahartiala, Timo Sorsa, Sture Andersson, Outi Mäkitie
High leptin concentration, low-grade inflammation, and insulin resistance often coexist in obese subjects; this adverse metabolic milieu may be the main culprit for increased fracture risk and impaired bone quality seen in patients with type 2 diabetes. We examined the associations of leptin, hs (high sensitivity)- CRP and insulin resistance with bone turnover markers (BTMs) and bone characteristics in 55 young obese adults (median BMI 40 kg/m2) and 65 non-obese controls. Mean age of the subjects was 19.5 ± 2...
2017: PloS One
https://www.readbyqxmd.com/read/28640230/total-flavonoids-of-drynariae-rhizoma-prevent-bone-loss-induced-by-hindlimb-unloading-in-rats
#14
Shuanghong Song, Ziyang Gao, Xujun Lei, Yinbo Niu, Yuan Zhang, Cuiqin Li, Yi Lu, Zhezhi Wang, Peng Shang
Drynariae Rhizoma is a kidney-tonifying herb that has a long history in clinical practice for the treatment of bone fractures and joint diseases in China. Flavonoids are considered to be its major active ingredients and are reported to ease bone loss in ovariectomized rats. However, the beneficial effects of the total flavonoids of Drynariae Rhizoma on osteoporosis caused by microgravity or mechanical inactivity remain unknown. This study assessed the effects of total Drynariae Rhizoma flavonoids (DRTF, Qihuang, Beijing, China, national medicine permit No...
June 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28639995/recovery-of-bone-mineral-density-following-discontinuation-of-tenofovir-based-hiv-pre-exposure-prophylaxis
#15
David V Glidden, Kathleen Mulligan, Vanessa McMahan, Peter L Anderson, Juan Guanira, Suwat Chariyalertsak, Susan P Buchbinder, Linda Gail Bekker, Mauro Schechter, Beatriz Grinsztejn, Robert M Grant
BACKGROUND: Oral tenofovir disoproxil fumarate (TDF) for HIV prevention and treatment is associated with decreases in bone mineral density (BMD). Previous reports suggest that these changes may be reversible after discontinuation of TDF. SETTING: A metabolic substudy of 498 participants in a randomized, placebo-controlled HIV prevention trial of oral co-formulated TDF with emtricitabine (TDF/FTC, Truvada®) for HIV preexposure prophylaxis (PrEP) enrolling a global sample of men who have sex with men and trans women...
June 19, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28639983/maxillary-sinus-membrane-elevation-with-simultaneous-installation-of-implants-without-the-use-of-a-graft-material-a-systematic-review
#16
Thomas Starch-Jensen, Søren Schou
OBJECTIVE: To compare implant treatment outcome after maxillary sinus membrane elevation with simultaneous installation of implants with or without the use of graft material applying the lateral window technique. MATERIALS AND METHODS: MEDLINE/PubMed, Cochrane Library, and Embase search in combination with a hand-search of relevant journals was conducted from January 1, 2004 to January 1, 2016. RESULTS: Thirteen studies fulfilled the inclusion criteria...
June 19, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28639518/selective-laser-melting-enabled-electrospinning-introducing-complexity-within-electrospun-membranes
#17
Thomas E Paterson, Selina N Beal, Martin E Santocildes-Romero, Alfred T Sidambe, Paul V Hatton, Ilida Ortega Asencio
Additive manufacturing technologies enable the creation of very precise and well-defined structures that can mimic hierarchical features of natural tissues. In this article, we describe the development of a manufacturing technology platform to produce innovative biodegradable membranes that are enhanced with controlled microenvironments produced via a combination of selective laser melting techniques and conventional electrospinning. This work underpins the manufacture of a new generation of biomaterial devices that have significant potential for use as both basic research tools and components of therapeutic implants...
June 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28639157/exercise-for-improving-bone-health-in-women-treated-for-stages-i-iii-breast-cancer-a-systematic-review-and-meta-analyses
#18
REVIEW
Canan P Fornusek, Sharon L Kilbreath
PURPOSE: The purpose of this study was to evaluate the efficacy of exercise, either alone or in combination with other interventions, compared to a control, for the preservation of bone mineral density (BMD) in early breast cancer (BC) patients. METHODS: A systematic search was conducted to identify randomized or quasi-randomized trials which met inclusion criteria including prescribed exercise for ≥12 months. Ten publications from seven randomized controlled trials (RCTs), involving 1199 participants, were identified...
June 21, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28639046/is-multidetector-ct-based-bone-mineral-density-and-quantitative-bone-microstructure-assessment-at-the-spine-still-feasible-using-ultra-low-tube-current-and-sparse-sampling
#19
Kai Mei, Felix K Kopp, Rolf Bippus, Thomas Köhler, Benedikt J Schwaiger, Alexandra S Gersing, Andreas Fehringer, Andreas Sauter, Daniela Münzel, Franz Pfeiffer, Ernst J Rummeny, Jan S Kirschke, Peter B Noël, Thomas Baum
OBJECTIVE: Osteoporosis diagnosis using multidetector CT (MDCT) is limited to relatively high radiation exposure. We investigated the effect of simulated ultra-low-dose protocols on in-vivo bone mineral density (BMD) and quantitative trabecular bone assessment. MATERIALS AND METHODS: Institutional review board approval was obtained. Twelve subjects with osteoporotic vertebral fractures and 12 age- and gender-matched controls undergoing routine thoracic and abdominal MDCT were included (average effective dose: 10 mSv)...
June 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28638994/adherence-to-mediterranean-diet-in-relation-to-bone-mineral-density-and-risk-of-fracture-a-systematic-review-and-meta-analysis-of-observational-studies
#20
Hanieh Malmir, Parvane Saneei, Bagher Larijani, Ahmad Esmaillzadeh
PURPOSE: We aimed to systematically review available data on the association between adherence to MD and BMD as well as risk of fractures and to summarize this information through a meta-analysis. METHODS: Previous studies in the field of adherence to MD in relation to BMD and risk of fracture were selected through searching PubMed, Scopus, ISI Web of Science and Google Scholar databases prior to June, 2016 using Mesh and non-Mesh relevant keywords. RESULTS: In the meta-analysis of four effect sizes, obtained from three studies, we found that adherence to MD was associated with a 21% reduced risk of hip fracture (overall RR 0...
June 21, 2017: European Journal of Nutrition
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