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https://www.readbyqxmd.com/read/29748623/plasma-microrna-panel-is-a-novel-biomarker-for-focal-segmental-glomerulosclerosis-and-associated-with-podocyte-apoptosis
#1
Bin Xiao, Li-Na Wang, Wei Li, Li Gong, Ting Yu, Qian-Fei Zuo, Hong-Wen Zhao, Quan-Ming Zou
Focal segmental glomerulosclerosis (FSGS) is a frequent glomerular disease, and is the common cause of nephrotic syndrome. However, there is no validated diagnostic blood biomarker for FSGS. Here, we performed a real-time PCR-based high-throughput miRNA profiling to identify the plasma signature for FSGS. We found four miRNAs (miR-17, miR-451, miR-106a, and miR-19b) were significantly downregulated in the plasma of FSGS patients (n = 97) compared with healthy controls (n = 124) in the training, validation, and blinded-test phases...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29655792/long-non-coding-rna-uca1-mir-182-pfkfb2-axis-modulates-glioblastoma-associated-stromal-cells-mediated-glycolysis-and-invasion-of-glioma-cells
#2
Zongze He, Chao You, Dongdong Zhao
Glioblastoma (GB) is the most common and deadliest malignant primary brain tumor with a high recurrence. In this study, lncRNA UCA1/miR-182 axis has been regarded as a nodal driver of glioma invasion mediated by GB-associated stromal cells (GASCs) and GASC-secreted chemokine CXCL14. In clinical specimens, CXCL14 upregulation in GASCs also correlated with poor prognosis. Notably, CXCL14-high GASCs mediated lncRNA UCA1 upregulation and miR-182 downregulation in glioma cells. Moreover, miR-182 directly bound to the fructose-2,6-biphosphatase PFKFB2; UCA1/miR-182 axis thereby modulated GASC-induced glycolysis in glioma cells...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29624878/elastographic-ultrasound-an-additional-image-tool-in-sj%C3%A3-gren-s-syndrome
#3
Eric Kimura-Hayama, Sergio Criales-Vera, Luis Azpeitia-Espinosa, Carlos Pacheco-Molina, Edgardo Reyes, Guadalupe Lima, Diego Hernandez-Ramirez, Luis Llorente, Gabriela Hernandez-Molina
AIM: To evaluate the stiffness of parotid and submandibular glands using elastography ultrasound and to correlate it with B-mode ultrasonographical, clinical and serological features, salivary profibrotic and inflammatory chemokines, and salivary gland fibrosis. METHODS: We performed B-mode and elastography ultrasound of major salivary glands of 26 patients with primary Sjögren's syndrome. We registered the shear wave velocity (SWV) and correlated it with the morphologic ultrasonographic changes assessed by the Hocevar scale...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29616282/a-large-lung-gene-expression-study-identifying-il1b-as-a-novel-player-in-airway-inflammation-in-copd-airway-epithelial-cells
#4
Gao Yi, Min Liang, Ming Li, Xiangming Fang, Jifang Liu, Yuxiong Lai, Jitao Chen, Wenxia Yao, Xiao Feng, La Hu, Chunyi Lin, Xinke Zhou, Zhaoyu Liu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive lung disease characterized by a mixture of small airway disease and lung tissue parenchymal destruction. Abnormal inflammatory responses to cigarette smoking and other noxious particles are generally thought to be responsible for causing of COPD. Since airway inflammation is a key factor in COPD progress, it is crucial to unravel its underlying molecular mechanisms. Unbiased analysis of genome-wide gene expression profiles in lung small airway epithelial cells provides a powerful tool to investigate this...
April 3, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29517684/cxcl14-and-nos1-expression-in-specimens-from-patients-with-stage-i-iiia-nonsmall-cell-lung-cancer-after-curative-resection
#5
Xiaoqin Ji, Zetian Shen, Benxin Zhao, Xi Yuan, Xixu Zhu
Many studies show that CXC chemokine ligand 14 (CXCL14) is highly expressed in tumor-associated stromal cells, promoting tumor cell growth, and invasion. Because of its unclear receptors, CXCL14-initiated intracellular signal cascades remain largely unknown. However, CXCL14 can regulate nitric oxide synthase 1 (NOS1) as its intracellular molecular target. In this paper, we investigated the expression of CXCL14 and NOS1 in specimens from patients with stage I-IIIA nonsmall cell lung cancer (NSCLC) after curative resection, and evaluated the prognostic significance of this gene expression in stromal fibroblasts and cancer cells...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29507348/global-gene-expression-analysis-in-an-in-vitro-fibroblast-model-of-idiopathic-pulmonary-fibrosis-reveals-potential-role-for-cxcl14-cxcr4
#6
Luis R Rodriguez, Margaret Emblom-Callahan, Mantej Chhina, Sarah Bui, Bilal Aljeburry, Luc H Tran, Rebecca Novak, Merte Lemma, Steven D Nathan, Geraldine M Grant
Idiopathic Pulmonary Fibrosis (IPF) is a progressive disorder that is marked by an over accumulation of activated fibroblast populations. Despite the improved understanding of many mechanisms within this disease, global gene expression analysis has few focused studies on the fibroblast, the central effector cell of progressive fibrosis. We present a unique analysis of IPF pulmonary fibroblasts as they transition through cell culture and identify in vitro altered cellular processes. Fibroblasts were isolated from diseased (n = 8) and non-diseased (n = 4) lungs...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29504253/interplay-between-porphyromonas-gingivalis-and-egf-signalling-in-the-regulation-of-cxcl14
#7
Jiamin Aw, Glen M Scholz, Noorjahan Laila Huq, Jennifer Huynh, Neil M O'Brien-Simpson, Eric C Reynolds
Porphyromonas gingivalis is a keystone pathogen in chronic periodontitis. Its expression of gingipain proteases (Kgp and RgpA/B) is central to the stimulation of chronic inflammation. In this study, we investigated the inflammatory response of oral epithelial cells to P. gingivalis. The cells responded by upregulating the expression of the orphan chemokine CXCL14. The stimulation of CXCL14 expression was largely triggered by the gingipain proteases and was dependent on the host protease-activated receptor PAR-3...
March 5, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29343878/cxcl14-like-immunoreactivity-exists-in-somatostatin-containing-endocrine-cells-and-in-the-lamina-propria-and-submucosal-somatostatinergic-nervous-system-of-mouse-alimentary-tract
#8
Hirohumi Suzuki, Kentaro Yamada, Yasuhiro Matsuda, Minoru Onozuka, Toshiharu Yamamoto
In the present study, we investigated the distribution of CXCL14 immunoreactive endocrine cells and neurons in mouse alimentary tract by immunohistochemistry. CXCL14 immunoreactive endocrine cells were found as closed-type cells in the stomach and open-type cells in the small intestine. The immunostaining of these endocrine cells corresponded with that of the somatostatin-containing endocrine cells. Only a few CXCL14 immunoreactive endocrine cells were seen in the large intestine. CXCL14 immunoreactive fibers were observed in the muscular layer from the stomach to the rectum with most abundance in the rectum...
December 26, 2017: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/29222527/the-chemokines-cxcl12-and-cxcl14-differentially-regulate-connective-tissue-markers-during-limb-development
#9
Sonya Nassari, Cédrine Blavet, Marie-Ange Bonnin, Sigmar Stricker, Delphine Duprez, Claire Fournier-Thibault
Connective tissues (CT) support and connect organs together. Understanding the formation of CT is important, as CT deregulation leads to fibrosis. The identification of CT specific markers has contributed to a better understanding of CT function during development. In developing limbs, Osr1 transcription factor is involved in the differentiation of irregular CT while the transcription factor Scx labels tendon. In this study, we show that the CXCL12 and CXCL14 chemokines display distinct expression pattern in limb CT during chick development...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29074725/adipose-tissue-macrophages-induce-hepatic-neutrophil-recruitment-and-macrophage-accumulation-in-mice
#10
Mitchell Bijnen, Tatjana Josefs, Ilona Cuijpers, Constantijn J Maalsen, José van de Gaar, Maria Vroomen, Erwin Wijnands, Sander S Rensen, Jan Willem M Greve, Marten H Hofker, Erik A L Biessen, Coen D A Stehouwer, Casper G Schalkwijk, Kristiaan Wouters
OBJECTIVE: Obesity is a risk factor for non-alcoholic steatohepatitis (NASH). This risk has been attributed to visceral adipose tissue (vAT) expansion associated with increased proinflammatory mediators. Accumulation of CD11c+ proinflammatory adipose tissue macrophages (ATM) is an important driver of vAT inflammation. We investigated the role of ATMs in hepatic inflammation during NASH development. DESIGN: vAT isolated from lean, obese or ATM-depleted (using clodronate liposomes) obese mice was transplanted to lean ldlr-/- acceptor mice...
October 26, 2017: Gut
https://www.readbyqxmd.com/read/28958187/nano-sized-zinc-oxide-and-silver-but-not-titanium-dioxide-induce-innate-and-adaptive-immunity-and-antiviral-response-in-differentiated-thp-1-cells
#11
Wing-Lam Poon, Harri Alenius, Joseph Ndika, Vittorio Fortino, Vesa Kolhinen, Arūnas Meščeriakovas, Mingfu Wang, Dario Greco, Anna Lähde, Jorma Jokiniemi, Jetty Chung-Yung Lee, Hani El-Nezami, Piia Karisola
Nano-sized metal oxides are currently the most manufactured nanomaterials (NMs), and are increasingly used in consumer products. Recent exposure data reveal a genuine potential for adverse health outcomes for a vast array of NMs, however the underlying mechanisms are not fully understood. To elucidate size-related molecular effects, differentiated THP-1 cells were exposed to nano-sized materials (n-TiO2, n-ZnO and n-Ag), or their bulk-sized (b-ZnO and b-TiO2 ) or ionic (i-Ag) counterparts, and genome-wide gene expression changes were studied at low-toxic concentrations (<15% cytotoxicity)...
September 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28928893/the-epigenetic-regulation-of-cxcl14-plays-a-role-in-the-pathobiology-of-oral-cancers
#12
Ryuji Nakayama, Kazumune Arikawa, Ujjal K Bhawal
Background: Chemokines selectively attract and activate leukocytes and play roles in a variety of homeostatic and disease processes. Explore the biological properties of CXCL14 seems complicated due to unknown functional characteristics of CXCL14 in cancer. Methods: To study the multistep process of oral cancer development, we analyzed oral samples spanning normalcy, dysplasia and cancer from multiple perspectives, revealing a cascade of progressive changes. Results: CXCL14 protein was expressed in the cytoplasm adjacent to tumors...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928016/cxcl14-acts-as-a-specific-carrier-of-cpg-dna-into-dendritic-cells-and-activates-toll-like-receptor-9-mediated-adaptive-immunity
#13
Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Rina Iwase, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka, Takahiko Hara
CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various types of CpG oligodeoxynucleotide (ODN) into the endosomes and lysosomes of bone marrow-derived dendritic cells (DCs), thereby activating Toll-like receptor 9 (TLR9). A combination of CpG ODN (ODN2395) plus CXCL14 induced robust production of IL-12 p40 by wild-type, but not Tlr9-knockout, DCs...
October 2017: EBioMedicine
https://www.readbyqxmd.com/read/28866083/the-developmental-transcriptome-landscape-of-receptive-endometrium-during-embryo-implantation-in-dairy-goats
#14
Lei Zhang, XiaoRui Liu, JunZe Liu, Li Ma, ZhanQin Zhou, YuXuan Song, BinYun Cao
Under natural conditions, some embryos cannot implant successfully because of the dysfunction of receptive endometrium (RE). Thus, it is imperative for us to study the molecular mechanisms involved in the formation of the RE from pre-receptive endometrium (PE). In this study, the endometrium from gestational day 5 (D5, PE) and gestational day 15 (D15, RE) dairy goats were selected to systematically analyze the transcriptome using strand-specific Ribo-Zero RNA-Seq, >120 million high-quality paired-end reads were generated and 47,616 transcripts were identified in the endometrium of dairy goats...
October 30, 2017: Gene
https://www.readbyqxmd.com/read/28634007/gene-expression-differences-between-ductal-carcinoma-in-situ-with-and-without-progression-to-invasive-breast-cancer
#15
Shusma C Doebar, Anieta M Sieuwerts, Vanja de Weerd, Hans Stoop, John W M Martens, Carolien H M van Deurzen
To understand the molecular alterations driving the progression of ductal carcinoma in situ (DCIS), we compared patients with pure DCIS and patients with DCIS and synchronous invasive breast cancer (IBC). Twelve patients with extensive pure DCIS were included as a representation of indolent lesions with limited invasive capacity. These cases were matched with 12 patients with a limited DCIS component and IBC, representing lesions with a high invasive potential. Matching included age and surrogate DCIS subtypes...
July 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28623356/high-risk-human-papillomavirus-e7-alters-host-dna-methylome-and-represses-hla-e-expression-in-human-keratinocytes
#16
Louis Cicchini, Rachel Z Blumhagen, Joseph A Westrich, Mallory E Myers, Cody J Warren, Charlotte Siska, David Raben, Katerina J Kechris, Dohun Pyeon
Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer. We have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression of antitumor immune responses. To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analyzed parallel global gene expression and DNA methylation using normal immortalized keratinocyte lines, NIKS, NIKS-16, NIKS-18, and NIKS-16∆E7...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28532450/lps-induced-systemic-inflammation-reveals-an-immunomodulatory-role-for-the-prion-protein-at-the-blood-brain-interface
#17
Ø Salvesen, M R Reiten, A Espenes, M K Bakkebø, M A Tranulis, C Ersdal
BACKGROUND: The cellular prion protein (PrP(C)) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrP(C) (PRNP (Ter/Ter)) provides a novel model for studying PrP(C) physiology. METHODS: In order to explore putative roles for PrP(C) in acute inflammatory responses, we performed a lipopolysaccharide (LPS, Escherichia coli O26:B6) challenge of 16 goats (8 PRNP (+/+) and 8 PRNP (Ter/Ter)) and included 10 saline-treated controls (5 of each PRNP genotype)...
May 22, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28465475/down-regulation-of-mir-29b-in-carcinoma-associated-fibroblasts-promotes-cell-growth-and-metastasis-of-breast-cancer
#18
Yonglei Liu, Jingling Zhang, Xiangjun Sun, Quanping Su, Cuiping You
Carcinoma associated fibroblasts (CAFs) play important roles in breast cancer development and progression. Recent studies show that microRNAs (miRNAs) are the main regulators in CAFs. MiR-29b is one of the significant down-regulated miRNAs in CAFs from the miRNA screening. The role of miR-29b in the interaction between CAFs and breast cancer is still unclear. In the present study, we investigated the effects of CAFs on breast cancer cell proliferation and metastasis regulated by miR-29b. We found that fibroblasts activated by co-cultured breast cancer cells produced higher levels of some chemokines like CCL11, CXCL14, which accelerated breast cancer cell growth and induced drug resistance and metastasis...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386116/cancer-associated-noncoding-mutations-affect-rna-g-quadruplex-mediated-regulation-of-gene-expression
#19
Mahdi Zeraati, Aaron L Moye, Jason W H Wong, Dilmi Perera, Mark J Cowley, Daniel U Christ, Tracy M Bryan, Marcel E Dinger
Cancer is a multifactorial disease driven by a combination of genetic and environmental factors. Many cancer driver mutations have been characterised in protein-coding regions of the genome. However, mutations in noncoding regions associated with cancer have been less investigated. G-quadruplex (G4) nucleic acids are four-stranded secondary structures formed in guanine-rich sequences and prevalent in the regulatory regions. In this study, we used published whole cancer genome sequence data to find mutations in cancer patients that overlap potential RNA G4-forming sequences in 5' UTRs...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28382159/a-crucial-role-of-cxcl14-for-promoting-regulatory-t-cells-activation-in-stroke
#20
Hsu-Tung Lee, Shih-Ping Liu, Chen-Huan Lin, Sophie Wei Lee, Chung Y Hsu, Huey-Kang Sytwu, Chia-Hung Hsieh, Woei-Cherng Shyu
Inflammatory processes have a detrimental role in the pathophysiology of ischemic stroke. However, little is known about the endogenous anti-inflammatory mechanisms in ischemic brain. Here, we identify CXCL14 as a critical mediator of these mechanisms. CXCL14 levels were upregulated in the ischemic brains of humans and rodents. Moreover, hypoxia inducible factor-1α (HIF-1α) drives hypoxia- or cerebral ischemia (CI)-dependent CXCL14 expression via directly binding to the CXCL14 promoter. Depletion of CXCL14 inhibited the accumulation of immature dendritic cells (iDC) or regulatory T cells (Treg) and increased the infarct volume, whereas the supplementation of CXCL14 had the opposite effects...
2017: Theranostics
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