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https://www.readbyqxmd.com/read/27861181/genetic-risk-for-inflammatory-bowel-disease-is-a-determinant-of-crohn-s-disease-development-in-chronic-granulomatous-disease
#1
Chengrui Huang, Suk See De Ravin, Adam R Paul, Theo Heller, Nancy Ho, Lisa Wu Datta, Christa S Zerbe, Beatriz E Marciano, Douglas B Kuhns, Howard A Kader, Steven M Holland, Harry L Malech, Steven R Brant
BACKGROUND: Approximately, one-third to one-half of children with chronic granulomatous disease (CGD) develop gastrointestinal inflammation characteristic of idiopathic inflammatory bowel disease (IBD), usually Crohn's disease. We hypothesized that the overall IBD genetic risk, determined by IBD genetic risk score (GRS), might in part determine IBD development in CGD. METHODS: We reviewed medical records to establish IBD diagnoses in CGD subjects seen at NIAID. IBD risk single nucleotide polymorphism genotypes were determined using the Immunochip, and GRS were estimated by Mangrove...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27824647/genetic-risk-for-inflammatory-bowel-disease-is-a-determinant-of-crohn-s-disease-development-in-chronic-granulomatous-disease
#2
Chengrui Huang, Suk S De Ravin, Adam R Paul, Theo Heller, Nancy Ho, Lisa Wu Datta, Christa S Zerbe, Beatriz E Marciano, Douglas B Kuhns, Howard A Kader, Steven M Holland, Harry L Malech, Steven R Brant
BACKGROUND: Approximately, one-third to one-half of children with chronic granulomatous disease (CGD) develop gastrointestinal inflammation characteristic of idiopathic inflammatory bowel disease (IBD), usually Crohn's disease. We hypothesized that the overall IBD genetic risk, determined by IBD genetic risk score (GRS), might in part determine IBD development in CGD. METHODS: We reviewed medical records to establish IBD diagnoses in CGD subjects seen at NIAID. IBD risk single nucleotide polymorphism genotypes were determined using the Immunochip, and GRS were estimated by Mangrove...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27787597/stromal-factors-involved-in-human-prostate-cancer-development-progression-and-castration-resistance
#3
Noemi Eiro, Jesus Fernandez-Gomez, Raquel Sacristán, Belen Fernandez-Garcia, Beatriz Lobo, Jorge Gonzalez-Suarez, Alejandro Quintas, Safwan Escaf, Francisco J Vizoso
PURPOSE: To detect new predictive markers from the prostate cancer tissue, to study the expression by cultured cancer-associated fibroblasts (CAFs) of stromal factors implicated in prostate carcinogenesis, and to compare their expressions in localized, metastatic, castration-sensitive (CSCP), castration-resistant prostate tumors (CRCP) as well as in fibroblasts from benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: The genomic expression of 20 stroma-derived factors, including the androgen receptor (AR), growth factors (FGF2, FGF7, FGF10, HGF, TGFβ, PDGFB), protein implicated in invasion (MMP-2, MMP-9 and MMP-11), inflammation (IL-6, IL-17, STAT-3 and NFκB), stroma/epithelium interaction (CDH11, FAP, CXCL12 and CXCL14) and chaperones (HPA1A and HSF1), was evaluated in cultured fibroblasts both from BHP and prostate carcinomas (PCa)...
October 27, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27769059/microarray-analysis-on-the-lncrna-expression-profile-in-male-hepatocelluar-carcinoma-patients-with-chronic-hepatitis-b-virus-infection
#4
Jianjun Niu, Yong Lin, Pingguo Liu, Yiwen Yu, Chenghao Su, Xiaomin Wang
Long non-coding RNAs are involved with development and progression of cancer, and the advance of microarray technology allows the researchers to investigate the complete expression profile of lncRNA in various kinds of sample. We enrolled 5 male primary HCC cases with chronic HBV infection and the HCC and normal tissues have been obtained during the resection surgery. After total RNA extraction, the lncRNA microarray analysis was conducted to determine the lncRNA and mRNA expression signals. 612 lncRNAs and 1,064 mRNAs were significantly up-regulated in HCC tissue while 656 lncRNAs and 1,532 mRNAs were down-regulated in HCC tissues...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27466507/chemokine-and-chemokine-receptor-profiles-in-metastatic-salivary-adenoid-cystic-carcinoma
#5
Ashley C Mays, Xin Feng, James D Browne, Christopher A Sullivan
AIM: To characterize the chemokine pattern in metastatic salivary adenoid cystic carcinoma (SACC). MATERIALS AND METHODS: Real-time polymerase chain reaction (RT-PCR) was used to compare chemokine and chemokine receptor gene expression in two SACC cell lines: SACC-83 and SACC-LM (lung metastasis). Chemokines and receptor genes were then screened and their expression pattern characterized in human tissue samples of non-recurrent SACC and recurrent SACC with perineural invasion...
August 2016: Anticancer Research
https://www.readbyqxmd.com/read/27405415/gene-expression-in-term-placentas-is-regulated-more-by-spinal-or-epidural-anesthesia-than-by-late-onset-preeclampsia-or-gestational-diabetes-mellitus
#6
Tove Lekva, Robert Lyle, Marie Cecilie Paasche Roland, Camilla Friis, Diana W Bianchi, Iris Z Jaffe, Errol R Norwitz, Jens Bollerslev, Tore Henriksen, Thor Ueland
Pre-eclampsia (PE) and gestational diabetes mellitus (GDM) are common complications of pregnancy, but the mechanisms underlying these disorders remain unclear. The aim was to identify the extent of altered gene expression in term placentas from pregnant women with late-onset PE and GDM compared to controls. RNAseq identified few significantly differentially regulated genes in placental biopsies between PE, GDM, or uncomplicated pregnancy (n = 10 each group). Five genes were altered in placentas from PE including 4 non-coding genes and Angiopoietin 2 (ANGPT2)...
July 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27401218/comprehensive-site-specific-whole-genome-profiling-of-stromal-and-epithelial-colonic-gene-signatures-in-human-sigmoid-colon-and-rectal-tissue
#7
Jason M Knight, Eunji Kim, Ivan Ivanov, Laurie A Davidson, Jennifer S Goldsby, Meredith A J Hullar, Timothy W Randolph, Andrew M Kaz, Lisa Levy, Johanna W Lampe, Robert S Chapkin
The strength of associations between various exposures (e.g., diet, tobacco, chemopreventive agents) and colorectal cancer risk may partially depend on the complex interaction between epithelium and stroma across anatomic subsites. Currently, baseline data describing genome-wide coding and long noncoding gene expression profiles in the healthy colon specific to tissue type and location are lacking. Therefore, colonic mucosal biopsies from 10 healthy participants who were enrolled in a clinical study to evaluate effects of lignan supplementation on gut resiliency were used to characterize the site-specific global gene expression signatures associated with stromal vs...
September 1, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27399917/expression-of-the-chemokine-cxcl14-and-cetuximab-dependent-tumour-suppression-in-head-and-neck-squamous-cell-carcinoma
#8
T Kondo, S Ozawa, T Ikoma, X-Y Yang, K Kanamori, K Suzuki, H Iwabuchi, Y Maehata, C Miyamoto, T Taguchi, T Kiyono, E Kubota, R-I Hata
Cetuximab, a monoclonal antibody against the epidermal growth factor receptor (EGFR), has been successfully used to treat some patients with colorectal cancer and those with head and neck squamous cell carcinoma (HNSCC). For the effective treatment, it is essential to first identify cetuximab-responsive patients. The level of EGFR expression and/or the presence of mutations in signalling molecules downstream of the EGFR pathway have been reported to be determining factors for cetuximab responsiveness in colorectal cancer patients; however, limited data have been reported for HNSCC patients...
2016: Oncogenesis
https://www.readbyqxmd.com/read/27349386/erratum-to-cxcl14-and-mcp1-are-potent-trophic-factors-associated-with-cell-migration-and-angiogenesis-leading-to-higher-regenerative-potential-of-dental-pulp-side-population-cells
#9
Yuki Hayashi, Masashi Murakami, Rei Kawamura, Ryo Ishizaka, Osamu Fukuta, Misako Nakashima
No abstract text is available yet for this article.
2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27340388/differential-chemokine-signature-between-human-preadipocytes-and-adipocytes
#10
Rosa Mistica C Ignacio, Carla R Gibbs, Eun-Sook Lee, Deok-Soo Son
Obesity is characterized as an accumulation of adipose tissue mass represented by chronic, low-grade inflammation. Obesity-derived inflammation involves chemokines as important regulators contributing to the pathophysiology of obesity-related diseases such as cardiovascular disease, diabetes and some cancers. The obesity-driven chemokine network is poorly understood. Here, we identified the profiles of chemokine signature between human preadipocytes and adipocytes, using PCR arrays and qRT-PCR. Both preadipocytes and adipocytes showed absent or low levels in chemokine receptors in spite of some changes...
June 2016: Immune Network
https://www.readbyqxmd.com/read/27259322/the-expression-of-hspd1-scube3-cxcl14-and-its-relations-with-the-prognosis-in-osteosarcoma
#11
Wenqing Liang, Chengwei Yang, Jiahao Peng, Yu Qian, Zirui Wang
The aim of the study was to explore the expression of three genes, HSPD1, SCUBE3, and CXCL14, in osteosarcoma cells and tissue, as well as their association with the prognosis of patients with osteosarcoma. The expression of HSPD1, SCUBE3, and CXCL14 in osteosarcoma cells was detected by using Western blotting method. siRNA was used to knockdown the expression of the three genes. CCK8 cell proliferation assay was used to observe the effect of siRNA interference on U2OS cell proliferation. The expression of the three genes in osteosarcoma tissue was detected employing immunohistochemical method...
December 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27143385/suppression-of-antitumor-immune-responses-by-human-papillomavirus-through-epigenetic-downregulation-of-cxcl14
#12
Louis Cicchini, Joseph A Westrich, Tao Xu, Daniel W Vermeer, Jennifer N Berger, Eric T Clambey, Denis Lee, John I Song, Paul F Lambert, Robert O Greer, John H Lee, Dohun Pyeon
UNLABELLED: High-risk human papillomaviruses (HPVs) are causally associated with multiple human cancers. Previous studies have shown that the HPV oncoprotein E7 induces immune suppression; however, the underlying mechanisms remain unknown. To understand the mechanisms by which HPV deregulates host immune responses in the tumor microenvironment, we analyzed gene expression changes of all known chemokines and their receptors using our global gene expression data sets from human HPV-positive and -negative head/neck cancer and cervical tissue specimens in different disease stages...
2016: MBio
https://www.readbyqxmd.com/read/27115465/expression-of-the-chemokine-cxcl14-in-the-tumour-stroma-is-an-independent-marker-of-survival-in-breast-cancer
#13
Elin Sjöberg, Martin Augsten, Jonas Bergh, Karin Jirström, Arne Östman
BACKGROUND: Expression of the chemokine CXCL14 has previously been shown to be elevated in the tumour stroma of, for example, prostate and breast cancer. Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. However, the prognostic significance of compartment-specific expression of CXCL14 has not been studied. METHODS: CXCL14 mRNA expression was analysed in a breast cancer tissue microarray (TMA) of formalin-fixed, paraffin-embedded tumours by the RNAscope 2...
May 10, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27055235/the-host-response-to-a-clinical-mdr-mycobacterial-strain-cultured-in-a-detergent-free-environment-a-global-transcriptomics-approach
#14
COMPARATIVE STUDY
Gina Leisching, Ray-Dean Pietersen, Vuyiseka Mpongoshe, Carel van Heerden, Paul van Helden, Ian Wiid, Bienyameen Baker
During Mycobacterium tuberculosis (M.tb) infection, the initial interactions between the pathogen and the host cell determines internalization and innate immune response events. It is established that detergents such as Tween alter the mycobacterial cell wall and solubilize various lipids and proteins. The implication of this is significant since induced changes on the cell wall affect macrophage uptake and the immune response to M.tb. Importantly, during transmission between hosts, aerosolized M.tb enters the host in its native form, i...
2016: PloS One
https://www.readbyqxmd.com/read/27004801/analysis-of-gene-expression-in-the-endocervical-epithelium-of-women-with-deep-endometriosis
#15
Alexander Kopelman, Manoel J B C Girão, Tatiana C S Bonetti, Cristina V Carvalho, Ismael Dale Cotrim Guerreiro da Silva, Eduardo Schor
Endometriosis affects approximately 12% of reproductive-age women and is currently diagnosed using invasive laparoscopic surgery. Differences in gene expression in the eutopic endometrium between women with and without endometriosis have been reported, and determining the reproducibility of these genetic differences in the endocervical epithelium would represent an important step toward developing novel diagnostic strategies. In this study, we analyzed gene expression in the endocervical epithelium in women with and without moderate or severe endometriosis...
September 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26911702/bisphenol-a-bpa-exposure-in-utero-leads-to-immunoregulatory-cytokine-dysregulation-in-the-mouse-mammary-gland-a-potential-mechanism-programming-breast-cancer-risk
#16
Catha Fischer, Ramanaiah Mamillapalli, Laura G Goetz, Elisa Jorgenson, Ysabel Ilagan, Hugh S Taylor
Bisphenol-A (BPA) is a ubiquitous estrogen-like endocrine disrupting compound (EDC). BPA exposure in utero has been linked to breast cancer and abnormal mammary gland development in mice. The recent rise in incidence of human breast cancer and decreased age of first detection suggests a possible environmental etiology. We hypothesized that developmental programming of carcinogenesis may involve an aberrant immune response. Both innate and adaptive immunity play a role in tumor suppression through cytolytic CD8, NK, and Th1 T-cells...
August 2016: Hormones & Cancer
https://www.readbyqxmd.com/read/26893359/transcriptomic-analysis-of-stage-1-versus-advanced-adult-granulosa-cell-tumors
#17
Maria Alexiadis, Simon Chu, Dilys Leung, Jodee A Gould, Tom Jobling, Peter J Fuller
Ovarian granulosa cell tumors (GCT) are hormonally-active neoplasms characterized, in the adult-subtype, by a mutation in the FOXL2 gene (C134W). They exhibit an indolent course with an unexplained propensity for late recurrence; ~80% of patients with aggressive, advanced stage tumors die from their disease; aside from surgery, therapeutic options are limited. To identify the molecular basis of advanced stage disease we have used whole transcriptome analysis of FOXL2 C134W mutation positive adult (a)GCT to identify genes that are differentially expressed between early (stage 1) and advanced (stage 3) aGCT...
March 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/26888271/-relationship-between-the-levels-and-variation-of-cxcl12-pdgf-cxcl14-in-cerebrospinal-fluid-of-optic-neuritis-and-neuromyelitis-optica
#18
Zhaocai Jiang, Shihui Wei, Zihao Liu, Hongyang Li, Tingjun Chen
OBJECTIVE: To explore the predictive value of the prognosis and outcome for optic neuritis (ON) and neuromyelitis optica (NMO) by investigating the levels and variation of CXCL12, PDGF and CXCL14 in CSF of patients with ON and NMO. METHODS: Retrospective study. Thirty-five patients with ON, 10 patients with NMO and 10 patients with cerebral venous sinus thrombosis (CVST) were scheduled in the research unit from September 2012 to September 2013 in Neuro-Ophthalmology Department of PLA General Hospital...
December 2015: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/26855449/cxcl14-like-immunoreactivity-exists-in-somatostatin-containing-cells-of-mouse-pancreas
#19
Hirohumi Suzuki, Toshiharu Yamamoto
Immunohistochemical techniques were employed to investigate the distribution of the chemokine CXCL14, in the mouse pancreas. CXCL14-immunoreactive cells were detected in the peripheral region of the pancreatic islets and were immunoreactive for somatostatin, but not for glucagon, insulin, and pancreatic polypeptide. Immunoelectron microscopy indicated that the CXCL14-like peptide and somatostatin co-existed in the secretory granules. CXCL14, secreted from somatostatin-containing cells, may modulate insulin secretion in a paracrine fashion, and play a novel role in glucose homeostasis in addition to its well-known chemotactic activities...
December 25, 2015: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/26733763/cxcl14-as-an-emerging-immune-and-inflammatory-modulator
#20
REVIEW
Jing Lu, Mita Chatterjee, Hannes Schmid, Sandra Beck, Meinrad Gawaz
CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity. The identity of the receptor for CXCL14 still remains obscure and therefore the intracellular signaling pathway is not entirely delineated. The present review summarizes the contribution of CXCL14 in these two aspects and discusses the biological mechanisms regulating CXCL14 expression and potential CXCL14 mediated functional implications in a variety of cells...
2016: Journal of Inflammation
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