Yanyang Xu, Chuangzhong Deng, Hongmin Chen, YiJiang Song, Huaiyuan Xu, Guohui Song, Xinliang Wang, Tianqi Luo, Weiqing Chen, Jiahui Ma, Anyu Zeng, Shujing Huang, Zhihao Chen, Jianchang Fu, Ming Gong, Yi Tai, Anfei Huang, Huixiong Feng, Jinxin Hu, Xiaojun Zhu, Qinglian Tang, Jinchang Lu, Jin Wang
Cooperation between primary malignant cells and stromal cells can mediate the establishment of lung metastatic niches. Here, we characterized the landscape of cell populations in the tumor microenvironment in treatment-naïve osteosarcoma using single cell RNA-sequencing and identified a stem cell-like cluster with tumor cell-initiating properties and pro-metastatic traits. CXCL14 was specifically enriched in the stem cell-like cluster and was also significantly upregulated in lung metastases compared to primary tumors...
January 31, 2024: Cancer Research