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https://www.readbyqxmd.com/read/29604189/risk-timing-and-predictors-of-disease-flare-after-discontinuation-of-anti-tumor-necrosis-factor-tnf-therapy-in-children-with-polyarticular-forms-of-juvenile-idiopathic-arthritis-jia-in-clinical-inactive-disease
#1
Daniel J Lovell, Anne L Johnson, Bin Huang, Beth S Gottlieb, Paula W Morris, Yukiko Kimura, Karen Onel, Suzanne C Li, Alexei A Grom, Janalee Taylor, Hermine I Brunner, Jennifer L Huggins, James J Nocton, Kathleen A Haines, Barbara S Edelheit, Michael Shishov, Lawrence K Jung, Calvin B Williams, Melissa S Tesher, Denise M Costanzo, Lawrence S Zemel, Jason A Dare, Murray H Passo, Kaleo C Ede, Judyann C Olson, Elaine A Cassidy, Thomas A Griffin, Linda Wagner-Weiner, Jennifer E Weiss, Larry B Vogler, Kelly A Rouster-Stevens, Timothy Beukelman, Randy Q Cron, Daniel Kietz, Kenneth Schikler, Jay Mehta, Tracy V Ting, James W Verbsky, B Anne Eberhard, Steven Spalding, Chen Chen, Edward H Giannini
OBJECTIVE: Determine the frequency, time-to-flare, and predictors of disease flare upon withdrawal of anti-tumor necrosis factor (TNF) therapy in children with polyarticular forms of juvenile idiopathic arthritis (PF-JIA) who demonstrated ≥ 6 continuous months of clinical inactive disease (CID). METHODS: In 16 centers 137 patients with PF-JIA in CID on anti-TNF therapy (42% of whom were also on methotrexate [MTX]) were prospectively followed. If CID was maintained for the initial 6 months on study anti-TNF was stopped and patients assessed for flare at 1, 2, 3, 4, 6, and 8 months...
March 31, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29287303/high-levels-of-dek-autoantibodies-in-sera-of-patients-with-polyarticular-juvenile-idiopathic-arthritis-and-with-early-disease-flares-following-cessation-of-anti-tumor-necrosis-factor-therapy
#2
Nirit Mor-Vaknin, Miguel Rivas, Maureen Legendre, Smriti Mohan, Ye Yuanfan, Theresa Mau, Anne Johnson, Bin Huang, Lili Zhao, Yukiko Kimura, Steven J Spalding, Paula W Morris, Beth S Gottlieb, Karen Onel, Judyann C Olson, Barbara S Edelheit, Michael Shishov, Lawrence K Jung, Elaine A Cassidy, Sampath Prahalad, Murray H Passo, Timothy Beukelman, Jay Mehta, Edward H Giannini, Barbara S Adams, Daniel J Lovell, David M Markovitz
OBJECTIVE: The nuclear oncoprotein DEK is an autoantigen associated with juvenile idiopathic arthritis (JIA), especially the oligoarticular subtype. DEK is a secreted chemotactic factor. Abundant levels of DEK and DEK autoantibodies are found in inflamed synovium in JIA. We undertook this study to further characterize the nature of DEK autoantibodies in screening serum samples from 2 different cohorts that consisted mostly of patients with JIA. METHODS: DEK autoantibody levels were analyzed in sera from 33 JIA patients, 13 patients with other inflammatory conditions, and 11 healthy controls, as well as in 89 serum samples from JIA patients receiving anti-tumor necrosis factor (anti-TNF) therapy...
April 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27390129/methods-for-developing-the-american-college-of-rheumatology-s-electronic-clinical-quality-measures
#3
Jinoos Yazdany, Rachel Myslinski, Amy Miller, Melissa Francisco, Sonali Desai, Gabriela Schmajuk, Diane Lacaille, Claire E Barber, Catalina Orozco, Matthew Bunyard, Martin J Bergman, Murray Passo, Eric L Matteson, Richard Olson, Stuart Silverman, Robert Warren, Kamala Nola, Mark Robbins
No abstract text is available yet for this article.
October 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/24677999/a68-the-role-of-serum-s100a12-protein-levels-in-maintaining-inactive-disease-on-anti-tumor-necrosis-factor-therapy-in-polyarticular-forms-of-juvenile-idiopathic-arthritis
#4
Claas Hinze, Dirk Foell, Anne Johnson, Yukiko Kimura, Steven J Spalding, Paula W Morris, Beth Gottlieb, Karen Onel, Judyann C Olson, Barbara Edelheit, Michael Shishov, Lawrence Jung, Elaine Cassidy, Sampath Prahalad, Murray H Passo, Timothy Beukelman, Jay Mehta, Kara M Schmidt, Edward H Giannini, Daniel J Lovell
BACKGROUND/PURPOSE: Treatment with anti-TNF therapies for polyarticular forms (extended oligoarthritis, rheumatoid factor [RF] +/- polyarthritis) of JIA (PF-JIA) results in up to 50% of patients (pts) demonstrating clinically inactive disease (CID). Serum S100A12 protein levels have been demonstrated to predict failure to maintain CID after withdrawal of methotrexate (MTX). This study determined the pattern of baseline serum S100A12 levels during CID on anti-TNF therapy. METHODS: In 16 centers, 137 pts with PF-JIA in CID on anti-TNF therapy were enrolled...
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24677973/a44-high-levels-of-dek-autoantibodies-may-predict-early-flare-following-cessation-of-anti-tnf-therapy
#5
Nirit Mor-Vaknin, Miguel Rivas, Maureen Legendre, Cynthia Yuanfan Ye, Anne Johnson, Bin Huang, Lili Zhao, Yuki Kimura, Steven J Spalding, Paula Morris, Beth Gottlieb, Karen Onel, Judyann C Olson, Barbara Edelheit, Michael Shishov, Lawrence K Jung, Elaine Cassidy, Sampath Prahalad, Murray H Passo, Timothy Beukelman, Jay Mehta, Kara M Schmidt, Edward H Giannini, Daniel J Lovell, David Markovitz
BACKGROUND/PURPOSE: The nuclear oncoprotein DEK is a biochemically distinct protein, modulating heterochromatin integrity, chemoattractant of neutrophils and T-cells and vital for the formation of neutrophil extracellular traps (NETs). NETs are important for resolution of inflammation suggesting that DEK contributes to the development of autoimmune diseases. High levels of DEK autoantibodies have been found in several autoimmune diseases including juvenile idiopathic arthritis (JIA) but their role in disease pathogenesis is not clear...
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24677947/a20-understanding-the-use-and-biology-of-tnf-therapy-in-jia-clinical-outcomes
#6
Daniel J Lovell, Anne Johnson, Yuki Kimura, Steven J Spalding, Paula W Morris, Beth S Gottlieb, Karen Onel, Judyann C Olson, Barbara Edelheit, Michael Shishov, Lawrence Jung, Elaine Cassidy, Sampath Prahalad, Murray H Passo, Timothy Beukelman, Jay Mehta, Kara M Schmidt, Dirk Foell, Bin Huang, Edward H Giannini
BACKGROUND/PURPOSE: Treatment with anti-TNF therapies (anti-TNF) for polyarticular forms (extended oligo, Poly RF +/-) of JIA (PF-JIA) results in >50% demonstrating clinically inactive disease (CID). The aims of this study were to determine the frequency, timing and predictors of flare upon withdrawal of anti-TNF in PF-JIA in CID. METHODS: In 16 centers 137 children with PF-JIA in CID on anti-TNF were enrolled and followed for ≥14 mos. If CID was maintained for the first 6 study mos, then anti-TNF was stopped...
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24677937/a180-a-population-management-tool-for-proactive-care-of-juvenile-idiopathic-arthritis-in-the-pediatric-rheumatology-care-and-outcomes-improvement-network
#7
Stacy P Ardoin, C April Bingham, Beth S Gottlieb, Ronald M Laxer, Murray H Passo, Daniel Lovell, Jennifer E Weiss, Sheetal S Vora, Tzielan C Lee, Nancy Griffith, Esi Morgan Dewitt
BACKGROUND/PURPOSE: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a multi-center, quality-improvement-focused learning network with a mission of improving outcomes for children and adolescents with juvenile idiopathic arthritis (JIA). PR-COIN has developed a population management tool which facilitates pro-active, coordinated health care communications and interventions that can be used in managing JIA patient populations. METHODS: The population management tool was developed with information technology expertise to link seamlessly to the PR-COIN longitudinal registry...
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24677906/a151-pediatric-rheumatology-care-and-outcomes-improvement-network-demonstrates-performance-improvement-on-juvenile-idiopathic-arthritis-quality-measures
#8
Julia G Harris, Esi Morgan Dewitt, Ronald M Laxer, Stacy P Ardoin, Beth S Gottlieb, Judyann C Olson, Murray H Passo, Jennifer E Weiss, Daniel J Lovell, Tzielan C Lee, Sheetal S Vora, Nancy Griffin, Jason A Stock, Lynn M Darbie, Catherine A Bingham
BACKGROUND/PURPOSE: Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a multi-site learning network designed to improve outcomes of juvenile idiopathic arthritis (JIA) care. Teams collect point of care data on measures of process of care and outcomes of care for the purposes of analysis to guide improvement activities. Eleven North American pediatric rheumatology centers participate. This report illustrates our improvement in several JIA process quality measures (QMs)...
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24677901/a12-the-role-of-serum-s100a12-protein-levels-in-disease-flare-after-withdrawal-of-anti-tumor-necrosis-factor-therapy-in-polyarticular-forms-of-juvenile-idiopathic-arthritis
#9
Claas Hinze, Dirk Foell, Anne Johnson, Yukiko Kimura, Steven J Spalding, Paula W Morris, Beth Gottlieb, Karen Onel, Judyann C Olson, Barbara Edelheit, Michael Shishov, Lawrence Jung, Elaine Cassidy, Sampath Prahalad, Murray H Passo, Timothy Beukelman, Jay Mehta, Kara M Schmidt, Edward H Giannini, Daniel J Lovell
BACKGROUND/PURPOSE: Anti-TNF therapy for polyarticular forms (extended oligo-, rheumatoid factor +/- polyarthritis) of JIA (PF-JIA) results in up to 50% of patients (pts) demonstrating clinically inactive disease (CID). This study determined the pattern of serum S100A12 levels at the time of withdrawal of anti-TNF therapy. METHODS: In 16 centers, 137 pts with PF-JIA in CID on anti-TNF therapy were enrolled and followed for at least 14 months (mos). During the first 6 study mos pts were maintained on anti-TNF therapy and if CID was maintained, then anti-TNF therapy was stopped...
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24677816/abstracts-from-the-2014-pediatric-rheumatology-symposium-april-3-6-2014-orlando-fl
#10
(no author information available yet)
No abstract text is available yet for this article.
March 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24650858/identifying-treatment-responders-and-predictors-of-improvement-after-cognitive-behavioral-therapy-for-juvenile-fibromyalgia
#11
RANDOMIZED CONTROLLED TRIAL
Soumitri Sil, Lesley M Arnold, Anne Lynch-Jordan, Tracy V Ting, James Peugh, Natoshia Cunningham, Scott W Powers, Daniel J Lovell, Philip J Hashkes, Murray Passo, Kenneth N Schikler, Susmita Kashikar-Zuck
The primary objective of this study was to estimate a clinically significant and quantifiable change in functional disability to identify treatment responders in a clinical trial of cognitive-behavioral therapy (CBT) for youth with juvenile fibromyalgia (JFM). The second objective was to examine whether baseline functional disability (Functional Disability Inventory), pain intensity, depressive symptoms (Children's Depression Inventory), coping self-efficacy (Pain Coping Questionnaire), and parental pain history predicted treatment response in disability at 6-month follow-up...
July 2014: Pain
https://www.readbyqxmd.com/read/23686969/utility-of-the-pedsql-rheumatology-module-as-an-outcome-measure-in-juvenile-fibromyalgia
#12
RANDOMIZED CONTROLLED TRIAL
Naomi E Joffe, Anne Lynch-Jordan, Tracy V Ting, Lesley M Arnold, Philip J Hashkes, Daniel J Lovell, Murray H Passo, Scott W Powers, Kenneth N Schikler, Susmita Kashikar-Zuck
OBJECTIVE: The PedsQL rheumatology module is currently the only available measure of disease-specific quality of life for children and adolescents with juvenile fibromyalgia (FM), but limited information has been published about the psychometric properties of the instrument, specifically in juvenile FM. The objective of this study was to assess there liability, validity, and sensitivity to change of the 5 scales (pain and hurt, daily activities, treatment, worry, and communication) of the patient and parent proxy versions of the PedsQL rheumatology module in the context of a randomized controlled trial in juvenile FM...
November 2013: Arthritis Care & Research
https://www.readbyqxmd.com/read/23541069/changes-in-pain-coping-catastrophizing-and-coping-efficacy-after-cognitive-behavioral-therapy-in-children-and-adolescents-with-juvenile-fibromyalgia
#13
Susmita Kashikar-Zuck, Soumitri Sil, Anne M Lynch-Jordan, Tracy V Ting, James Peugh, Kenneth N Schikler, Philip J Hashkes, Lesley M Arnold, Murray Passo, Margaret M Richards-Mauze, Scott W Powers, Daniel J Lovell
UNLABELLED: A recent randomized multisite clinical trial found that cognitive-behavioral therapy (CBT) was significantly more effective than fibromyalgia education (FE) in reducing functional disability in adolescents with juvenile fibromyalgia (JFM). The primary objective of this study was to examine the psychological processes of CBT effectiveness by evaluating changes in pain coping, catastrophizing, and coping efficacy and to test these changes as mediators of continued improvements in functional disability and depressive symptoms at 6-month follow-up...
May 2013: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/23139240/pulmonary-hypertension-and-other-potentially-fatal-pulmonary-complications-in-systemic-juvenile-idiopathic-arthritis
#14
Yukiko Kimura, Jennifer E Weiss, Kathryn L Haroldson, Tzielan Lee, Marilynn Punaro, Sheila Oliveira, Egla Rabinovich, Meredith Riebschleger, Jordi Antón, Peter R Blier, Valeria Gerloni, Melissa M Hazen, Elizabeth Kessler, Karen Onel, Murray H Passo, Robert M Rennebohm, Carol A Wallace, Patricia Woo, Nico Wulffraat
OBJECTIVE: Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin-1 (IL-1) and IL-6 inhibitors appear to be effective treatments. Pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), and alveolar proteinosis (AP) have recently been reported with increased frequency in systemic JIA patients. Our aim was to characterize and compare systemic JIA patients with these complications to a larger cohort of systemic JIA patients...
May 2013: Arthritis Care & Research
https://www.readbyqxmd.com/read/22870498/juvenile-idiopathic-arthritis-management-and-therapeutic-options
#15
Natasha M Ruth, Murray H Passo
THE GOALS OF TREATMENT FOR JUVENILE IDIOPATHIC ARTHRITIS (JIA) INCLUDE: suppression of inflammation, achievement of remission, relief of pain, maintenance of function and doing so with minimal toxicity. Important discoveries over the past 10-15 years have led to more targeted treatments for children with JIA. The International League of Associations for Rheumatology (ILAR) classification system for childhood arthritides, better assessment tools for clinical response, improved definitions of remission, new imaging techniques and evidence in gene expression profiling have all contributed to the development of more targeted treatments...
April 2012: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/22108765/cognitive-behavioral-therapy-for-the-treatment-of-juvenile-fibromyalgia-a-multisite-single-blind-randomized-controlled-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Susmita Kashikar-Zuck, Tracy V Ting, Lesley M Arnold, Judy Bean, Scott W Powers, T Brent Graham, Murray H Passo, Kenneth N Schikler, Philip J Hashkes, Steven Spalding, Anne M Lynch-Jordan, Gerard Banez, Margaret M Richards, Daniel J Lovell
OBJECTIVE: Juvenile fibromyalgia syndrome (FMS) is a chronic musculoskeletal pain disorder in children and adolescents for which there are no evidence-based treatments. The objective of this multisite, single-blind, randomized clinical trial was to test whether cognitive-behavioral therapy (CBT) was superior to fibromyalgia (FM) education in reducing functional disability, pain, and symptoms of depression in juvenile FMS. METHODS: Participants were 114 adolescents (ages 11-18 years) with juvenile FMS...
January 2012: Arthritis and Rheumatism
https://www.readbyqxmd.com/read/22034112/effectiveness-of-dexamethasone-iontophoresis-for-temporomandibular-joint-involvement-in-juvenile-idiopathic-arthritis
#17
Rina Mina, Paula Melson, Stephanie Powell, Marepalli Rao, Claas Hinze, Murray Passo, T Brent Graham, Hermine I Brunner
OBJECTIVE: Temporomandibular joint (TMJ) involvement is common in juvenile idiopathic arthritis (JIA). Dexamethasone iontophoresis (DIP) uses low-grade electric currents for transdermal dexamethasone delivery into deeper anatomic structures. The purpose of this study was to assess the safety and effectiveness of DIP for the treatment of TMJ involvement in JIA, and to delineate variables that are associated with improvement after DIP. METHODS: Medical records of all JIA patients who underwent DIP for TMJ involvement at a larger tertiary pediatric rheumatology center from 1997-2011 were reviewed...
November 2011: Arthritis Care & Research
https://www.readbyqxmd.com/read/20842714/measuring-process-of-arthritis-care-a-proposed-set-of-quality-measures-for-the-process-of-care-in-juvenile-idiopathic-arthritis
#18
Daniel J Lovell, Murray H Passo, Timothy Beukelman, Suzanne L Bowyer, Beth S Gottlieb, Michael Henrickson, Norman T Ilowite, Yukiko Kimura, Esi Morgan DeWitt, Jill Segerman, Leonard D Stein, Janalee Taylor, Richard K Vehe, Edward H Giannini
OBJECTIVE: The ability to assess quality of care is a necessary component of continuous quality improvement. The assessment typically is accomplished by determination of compliance with a defined set of quality measures (QMs). The objective of this effort was to establish a set of QMs for the assessment of the process of care in juvenile idiopathic arthritis (JIA). METHODS: A 12-member working group composed of representatives from the American College of Rheumatology, American Academy of Pediatrics, American Board of Pediatrics, and Association of Rheumatology Health Professionals was assembled to guide the project...
January 2011: Arthritis Care & Research
https://www.readbyqxmd.com/read/20807363/leukocyte-adhesion-deficiency-type-1-presenting-with-recurrent-pyoderma-gangrenosum-and-flaccid-scarring
#19
Claas H Hinze, Anne W Lucky, Kevin E Bove, Rebecca A Marsh, Jack H Bleesing, Murray H Passo
We report an 11-year-old boy with a longstanding history of recurrent pyoderma gangrenosum and abnormal wound healing who eventually developed a fatal invasive fungal infection. This article emphasizes the importance to consider leukocyte adhesion deficiency type 1 in the differential diagnosis of patients with recurrent skin ulcers.
September 2010: Pediatric Dermatology
https://www.readbyqxmd.com/read/20688804/controlled-follow-up-study-of-physical-and-psychosocial-functioning-of-adolescents-with-juvenile-primary-fibromyalgia-syndrome
#20
Susmita Kashikar-Zuck, Irina S Parkins, Tracy V Ting, Emily Verkamp, Anne Lynch-Jordan, Murray Passo, Thomas Brent Graham
OBJECTIVES: Currently, there are no prospective studies exploring the prognosis of patients with juvenile primary FM syndrome (JPFS) or their physical, emotional and social outcomes as they enter the early adult years. The primary objective of this study was to assess long-term outcomes of a paediatric sample of clinically referred JPFS patients and their matched healthy controls. METHODS: Participants were 48 youths (current mean age = 19 years) diagnosed with JPFS in childhood or adolescence and 43 healthy controls matched in age, gender and race...
November 2010: Rheumatology
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