keyword
https://read.qxmd.com/read/38536505/metabolic-changes-contribute-to-maladaptive-right-ventricular-hypertrophy-in-pulmonary-hypertension-beyond-pressure-overload-an-integrative-imaging-and-omics-investigation
#1
JOURNAL ARTICLE
Inés García-Lunar, Inmaculada Jorge, Jorge Sáiz, Núria Solanes, Ana Paula Dantas, Juan José Rodríguez-Arias, María Ascaso, Carlos Galán-Arriola, Francisco Rafael Jiménez, Elena Sandoval, Jorge Nuche, Maria Moran-Garrido, Emilio Camafeita, Montserrat Rigol, Javier Sánchez-Gonzalez, Valentín Fuster, Jesús Vázquez, Coral Barbas, Borja Ibáñez, Daniel Pereda, Ana García-Álvarez
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group...
March 27, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38535113/incremental-value-of-biventricular-strain-in-patients-with-severe-aortic-stenosis
#2
JOURNAL ARTICLE
Camille Sarrazyn, Xavier Galloo, Maria Chiara Meucci, Steele C Butcher, Kensuke Hirsawa, Rinchyenkhand Myagmardorj, Frank van der Kley, Tine De Backer, Jeroen J Bax, Nina Ajmone Marsan
(1) Background: Left ventricular global longitudinal (LVGLS) and right ventricular free wall strain (RVFWS) demonstrated separate prognostic values in patients with severe aortic stenosis (AS). However, studies evaluating the combined assessment of LVGLS and RVFWS have shown contradictory results. This study explored the prognostic value of combining LVGLS and RVFWS in a large group of severe AS patients referred for transcatheter aortic valve implantation. (2) Methods: Patients were classified into three groups: preserved (LVGLS ≥ 15% AND RVFWS > 20%), single-ventricle impaired (LVGLS < 15% OR RVFWS ≤ 20%), or biventricular-impaired strain group (LVGLS < 15% AND RVFWS ≤ 20%)...
March 13, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38512488/predicting-peri-operative-cardiorespiratory-adverse-events-in-children-with-idiopathic-pulmonary-arterial-hypertension-undergoing-cardiac-catheterization-using-echocardiography-a-cohort-study
#3
JOURNAL ARTICLE
Timothy J W Dawes, Valentine Woodham, Emma Sharkey, Angus McEwan, Graham Derrick, Vivek Muthurangu, Shahin Moledina, Lucy Hepburn
General anesthesia in children with idiopathic pulmonary arterial hypertension (PAH) carries an increased risk of peri-operative cardiorespiratory complications though risk stratifying individual children pre-operatively remains difficult. We report the incidence and echocardiographic risk factors for adverse events in children with PAH undergoing general anesthesia for cardiac catheterization. Echocardiographic, hemodynamic, and adverse event data from consecutive PAH patients are reported. A multivariable predictive model was developed from echocardiographic variables identified by Bayesian univariable logistic regression...
March 21, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38507938/atypical-teratoid-rhabdoid-tumor-of-the-central-nervous-system-clinicopathological-features-of-two-challenging-cases
#4
Sawsan Ismail, Lina Ghanem, Leen Ibrahim, Mohammed Abdulrahman, Zuheir Alshehabi, Rana Issa
INTRODUCTION: Atypical Teratoid/Rhabdoid Tumor (AT/RT) is a rare aggressive neoplasm that mainly affects the pediatric population with a peak incidence in the first two years of life and a slight male predominance, whereas presentation of this neoplasm in older ages is extremely rare. CASE PRESENTATION: Herein, we present two cases of AT/RT. In the first case, a 9-year-old female presented with diplopia, dizziness, headache, and morning vomiting. CT Scan of the head demonstrated a heterogeneous mass in the left frontal-parietal region with vasogenic edema and midline deviation...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38507153/myocardial-work-of-the-systemic-right-ventricle-and-its-association-with-outcomes
#5
JOURNAL ARTICLE
Elena Surkova, Bálint Károly Lakatos, Alexandra Fábián, Attila Kovács, Roxy Senior, Wei Li
We aimed to evaluate clinical and prognostic significance of myocardial work parameters of the systemic right ventricle (SRV). Thirty-eight patients with the SRV underwent echocardiographic assessment of the SRV systolic function including 3D-echocardiography derived ejection fraction, 2D longitudinal strain and myocardial work analysis. The study endpoint was the combination of all-cause mortality and heart transplantation. Global constructive work (GCW) and global work index (GWI) demonstrated moderate correlation with the 3DE-derived SRV ejection fraction (EF) (Rho 0...
March 20, 2024: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/38506050/detection-of-occult-thrombosis-in-individuals-with-fontan-circulation-by-cardiac-mri
#6
JOURNAL ARTICLE
Samantha F Curtis, Mariah Cicioni, Alexandria Mullikin, Jason Williams, J Michael Campbell, Piers C A Barker, Andrew W McCrary
OBJECTIVE: Identifying thrombus formation in Fontan circulation has been highly variable, with reports between 17 and 33%. Initially, thrombus detection was mainly done through echocardiograms. Delayed-enhancement cardiac MRI is emerging as a more effective imaging technique for thrombus identification. This study aims to determine the prevalence of occult cardiac thrombosis in patients undergoing clinically indicated cardiac MRI. METHODS: A retrospective chart review of children and adults in the Duke University Hospital Fontan registry who underwent delayed-enhancement cardiac MRI...
March 20, 2024: Cardiology in the Young
https://read.qxmd.com/read/38503338/a-hybrid-neural-ordinary-differential-equation-model-of-the-cardiovascular-system
#7
JOURNAL ARTICLE
Gevik Grigorian, Sandip V George, Sam Lishak, Rebecca J Shipley, Simon Arridge
In the human cardiovascular system (CVS), the interaction between the left and right ventricles of the heart is influenced by the septum and the pericardium. Computational models of the CVS can capture this interaction, but this often involves approximating solutions to complex nonlinear equations numerically. As a result, numerous models have been proposed, where these nonlinear equations are either simplified, or ventricular interaction is ignored. In this work, we propose an alternative approach to modelling ventricular interaction, using a hybrid neural ordinary differential equation (ODE) structure...
March 2024: Journal of the Royal Society, Interface
https://read.qxmd.com/read/38495662/high-risk-congenital-heart-disease-in-pregnancy
#8
REVIEW
Saurabh Rajpal, Carla P Rodriguez
High-risk congenital heart disease (CHD) in pregnancy presents a complex clinical challenge. With improved medical care and increased survival rates, a growing population of adults with complex CHD are surviving to adulthood, including women of reproductive age. This chapter focuses on risk stratification and management of pregnant women with high-risk CHD, emphasizing the importance of considering both anatomical and physiological complexity. Maternal physiological changes, such as blood volume increase, cardiac output changes, and alterations in vascular resistance, can significantly impact high-risk CHD patients...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38493466/spontaneous-closure-of-iatrogenic-epicardial-coronary-pseudoaneurysm-with-fistula-to-right-ventricle-following-post-stenting-perforation
#9
JOURNAL ARTICLE
Wojciech Jan Skorupski, Marta Kałużna-Oleksy, Grzegorz Krupka, Włodzimierz Skorupski, Marek Grygier, Maciej Lesiak
No abstract text is available yet for this article.
March 17, 2024: Kardiologia Polska
https://read.qxmd.com/read/38489091/aspirin-responsiveness-in-a-cohort-of-pediatric-patients-with-right-ventricle-to-pulmonary-artery-conduits-and-transcatheter-valve-replacement-systems
#10
JOURNAL ARTICLE
Sean T Kelleher, Irene E Regan, Dermot Cox, Kathryn Shaw, Orla Franklin, Damien P Kenny, Kevin P Walsh, Colin J McMahon
The aim of this study was to determine the rate of aspirin responsiveness in a cohort of pediatric patients with in situ xenograft valved right ventricle to pulmonary artery (RV-PA) conduits and/or transcatheter valve replacements (TVR). Aspirin is routinely prescribed to these patients. Optimizing anti-platelet therapy could promote valve longevity and reduce the risk of infective endocarditis in this at-risk group. This was a prospective, observational study. Patients were recruited from both ward and outpatient settings...
March 15, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38488184/novel-application-of-the-diabolo-technique-to-restrict-pulmonary-blood-flow-in-a-single-ventricle-patient-with-a-right-ventricle-to-pulmonary-artery-conduit
#11
Helen M Stanley, Ryan Callahan
Balancing pulmonary and systemic circulations in single ventricle patients with a conduit after Stage 1 palliation is challenging. A transcatheter intervention for excessive pulmonary blood flow would provide benefit. We report a case of a critically ill single ventricle patient with symptoms of excessive pulmonary blood flow after Stage 1 despite maximal medical therapy. The patient underwent percutaneous intraluminal downsizing of the right ventricle to pulmonary artery conduit using a novel application of the Diabolo-covered stent technique, with subsequent clinical improvement...
March 15, 2024: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/38485103/sudden-unexpected-intrapartum-death-and-left-ventricular-noncompaction-involving-the-right-ventricle
#12
Giulia Ottaviani, Tobia Tomasello, Francesca Boggio, Letterio Runza, Alessandro Del Gobbo, L Maximilian Buja
Left ventricular noncompaction (LVNC), involving mainly the right ventricle, is a rare form of congenital heart disorder characterized by a developmental arrest in myocardial compaction, resulting in a spongy appearance of the myocardium, mainly of the right ventricle, rarely detected in fetuses. We report the case of a female fetus with a gestational age of 41+4 weeks who came to our attention for intrapartum sudden unexpected death, resulting in stillbirth. The ventricular walls, particularly the right ventricular wall, appeared thick, hypertrabeculated and spongy, leading to the diagnosis of LVNC involving mainly the right ventricle...
March 12, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38476992/correlation-between-transcranial-ultrasound-and-ct-head-to-detect-clinically-significant-conditions-in-post-craniectomy-patients-performed-by-emergency-physician-a-pilot-study
#13
JOURNAL ARTICLE
Rahul Chouhan, Tej P Sinha, Sanjeev Bhoi, Atin Kumar, Deepak Agrawal, Jamshed Nayer, Ravindra M Pandey, Praveen Aggarwal, Meera Ekka, Prakash R Mishra, Akshay Kumar, Divya C Chouhan
BACKGROUND: The main objective is to detect clinically significant conditions by transcranial ultrasound (TCS) in post-decompressive craniectomy (DC) patients who come to the emergency department. MATERIALS AND METHODS: This was a cross-sectional observational study. We studied 40 post-DC patients. After primary stabilization, TCS was done. Computer tomography of head was done within 2 hours of performing TCS. The correlation between both modalities were assessed by the measurement of lateral ventricle (LV) (Bland-Altman plot), Midline shift and mass lesion...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38473855/behavior-of-hypertrophied-right-ventricle-during-the-development-of-left-ventricular-failure-due-to-myocardial-infarction
#14
REVIEW
Naranjan S Dhalla, Karina Oliveira Mota, Carla Maria Lins de Vasconcelos, Adriana Adameova
In order to determine the behavior of the right ventricle, we have reviewed the existing literature in the area of cardiac remodeling, signal transduction pathways, subcellular mechanisms, β-adrenoreceptor-adenylyl cyclase system and myocardial catecholamine content during the development of left ventricular failure due to myocardial infarction. The right ventricle exhibited adaptive cardiac hypertrophy due to increases in different signal transduction pathways involving the activation of protein kinase C, phospholipase C and protein kinase A systems by elevated levels of vasoactive hormones such as catecholamines and angiotensin II in the circulation at early and moderate stages of heart failure...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468114/establishment-of-a-biaxial-testing-system-for-characterization-of-right-ventricle-viscoelasticity-under-physiological-loadings
#15
JOURNAL ARTICLE
Kellan Roth, Wenqiang Liu, Kristen LeBar, Matt Ahern, Zhijie Wang
PURPOSE: Prior studies have indicated an impact of cardiac muscle viscoelasticity on systolic and diastolic functions. However, the studies of ventricular free wall viscoelasticity, particularly for that of right ventricles (RV), are limited. Moreover, investigations on ventricular passive viscoelasticity have been restricted to large animals and there is a lack of data on rodent species. To fill this knowledge gap, this study aims to develop a biaxial tester that induces high-speed physiological deformations to characterize the passive viscoelasticity of rat RVs...
March 11, 2024: Cardiovascular Engineering and Technology
https://read.qxmd.com/read/38464466/in-situ-myocardial-regeneration-with-tissue-engineered-cardiac-patch-using-spheroid-based-3-dimensional-tissue
#16
JOURNAL ARTICLE
Yojiro Koda, Tatsuya Watanabe, Keigo Kawaji, Fei Mo, Andrew D Beaser, Marcella Vaicik, Narutoshi Hibino, Takeyoshi Ota
BACKGROUND: We have developed a tissue engineered cardiac patch derived from a 3-dimensional (3D) myocardial tissue reinforced with extracellular matrix in an effort to enhance in situ myocardial regeneration. The feasibility of the patch was evaluated in a porcine model by various modalities to assess both the constructive and functional aspects of regeneration. METHODS: A spheroid-based 3D multicellular tissue was created using a 3D net mold system that incorporated cardiomyocytes and embryonic fibroblast cells...
March 2024: Ann Thorac Surg Short Rep
https://read.qxmd.com/read/38462324/surgical-considerations-in-adult-congenital-heart-disease-heart-failure
#17
REVIEW
William H Marshall V, Patrick McConnell
Surgical intervention is often used in the management of heart failure in patients with adult congenital heart disease. This review addresses anatomic variations and complications due to prior surgical interventions, including sternal reentry, collateral vessels, and the neo-aortic root after the Damus-Kaye-Stansel procedure. Surgical considerations for systemic atrioventricular valvular surgery, Fontan revision, and advanced heart failure therapies including ventricular assist devices, heart transplant, and combined heart-liver transplant are discussed, with a focus on unique patient populations including those with systemic right ventricles and those with Fontan circulation...
April 2024: Heart Failure Clinics
https://read.qxmd.com/read/38462320/special-considerations-for-mechanical-circulatory-support-or-device-therapy-in-adult-congenital-heart-disease-heart-failure
#18
REVIEW
Rafael Alonso-Gonzalez, Guillermo Agorrody
Heart failure has become the leading cause of mortality in adult congenital heart disease (ACHD) patients after the fifth decade of life. There is scanty evidence supporting the use of guideline-directed medical therapy in ACHD, especially in systemic right ventricle or single ventricle physiology. In complex patients, diagnosing heart failure and timely referral for advanced therapies are challenging. Mechanical circulatory support has been significantly developed over the past decade and has recently emerged as a feasible therapeutic option for these patients...
April 2024: Heart Failure Clinics
https://read.qxmd.com/read/38462318/medical-therapy-and-monitoring-in-adult-congenital-heart-disease-heart-failure
#19
REVIEW
Jeremy Nicolarsen, James Mudd, Andrew Coletti
Heart failure (HF) in adult congenital heart disease (ACHD) is an increasingly common problem facing ACHD and advanced heart disease and transplant providers. Patients are highly nuanced, and therapies are poorly studied. Standard HF medications are often used in patients who are not targets of large clinical trials. HF management in this data-free zone requires focused, comprehensive team-based care and close follow-up and communication with patients.
April 2024: Heart Failure Clinics
https://read.qxmd.com/read/38461202/right-ventricular-dyssynchrony-for-the-prediction-of-prognosis-in-patients-with-systemic-lupus-erythematosus-aaociated-pulmonary-arterial-hypertension-a-study-with-two-dimensional-speckle-tracking
#20
JOURNAL ARTICLE
Xiao-Lan Tan, Yan Deng, Wei-Fang Lan, Ping Dai, Jie Hu, Jing Lan
Pulmonary arterial hypertension (PAH) is a common complication of systemic lupus erythematosus (SLE), and PAH can cause right ventricle (RV) remodel and dyssynchrony. The aim of this study was to explore the value of RV dyssynchrony in predicting adverse clinical events in patients with systemic lupus erythematosus-aaociated pulmonary arterial hypertension (SLE-PAH) using two-dimensional speckle tracking echocardiography (2D-STE). A total of 53 patients with SLE-PAH were enrolled in this study. The dyssynchrony of the RV (RV-SD6) was evaluated by 2D-STE...
March 9, 2024: International Journal of Cardiovascular Imaging
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