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Larynx reflux

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https://www.readbyqxmd.com/read/28620964/does-gene-expression-in-laryngeal-sub-sites-differ-between-patients-with-laryngopharyngeal-reflux-and-controls
#1
John M Wood, Damian J Hussey, Charmaine M Woods, David Astill, David I Watson, Bernard Lee, A Simon Carney
OBJECTIVE: to identify laryngeal mRNA gene changes in patients with laryngopharyngeal reflux (LPR). METHOD: Laryngeal biopsies from non-smoking LPR patients (n=10; Reflux Symptom Index (RSI) >12 and a Reflux Finding Score (RFS) >6) and controls (n=9; RSI <12 and RFS <6) were collected from 4 sub-sites (true vocal cord, false vocal cord, medial arytenoid, posterior commissure) of the larynx. qRT-PCR analyses were conducted on 20 reflux and inflammation related genes, including interleukin 6 and 8, cytokeratin 8 and 14, mucin genes MUC 1, 2, 3B, 4, 5B, 6 & 7, and carbonic anhydrase III...
June 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28600380/cohort-profile-the-nordic-antireflux-surgery-cohort-nordasco
#2
John Maret-Ouda, Karl Wahlin, Miia Artama, Nele Brusselaers, Martti Färkkilä, Elsebeth Lynge, Fredrik Mattsson, Eero Pukkala, Pål Romundstad, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren
PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. PARTICIPANTS: Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries)...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28412967/factors-associated-with-lingual-tonsil-hypertrophy-in-canadian-adults
#3
Matthew S Harris, Brian W Rotenberg, Kathryn Roth, Leigh J Sowerby
BACKGROUND: Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adult patient is unclear and likely multifactorial. Previous studies have suggested that the lingual tonsils may undergo compensatory hyperplasia post-tonsillectomy in children, although it is unknown if this occurs or persists into adulthood. The purpose of this study was to determine what factors are associated with LTH in a population of Canadian adults...
April 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28266945/allergic-laryngitis-unraveling-the-myths
#4
Robert J Stachler, James P Dworkin-Valenti
PURPOSE OF REVIEW: This article provides a thorough review of the literature highlighting the articles that have advanced our knowledge about the sensitivity of the larynx to allergens in the air or ones consumed. This area of inquiry requires continued interest and investigation. As the field of clinical laryngology changes, and more information is discovered about the possible causal association between allergy and vocal pathologies, practicing otolaryngologists, allergists, and other medical professionals may discover more comprehensive methods to evaluate and treat their allergic patients, particularly those who present with complaints of dysphonia, dysphagia, laryngopharyngeal reflux (LPR), and/or dyspnea...
June 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28225537/laryngeal-sensitivity-testing-in-youth-with-exercise-inducible-laryngeal-obstruction
#5
Irena Hočevar-Boltežar, Uroš Krivec, Maja Šereg-Bahar
Exercise-inducible laryngeal obstruction (EILO) has been recognized as a not rare respiratory problem in youth practicing sports. The aim of the study was to test the mechanosensitivity of the larynx, and to identify the factors affecting it in a group of youth with proven EILO. Laryngeal sensory testing was performed in 54 adolescents and young adults with EILO. Laryngeal mucosal alterations were assessed according to the Reflux Finding Score (RFS). The data concerning diseases possibly affecting the upper airway, findings of previously performed flexible videolaryngoscopy during exercise, and RFS score were compared between the participants with laryngeal hyposensitivity and those with normal sensitivity...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28098054/long-term-esophageal-motility-changes-after-thyroidectomy-associations-with-aerodigestive-disorders
#6
G Scerrino, A Inviati, S Di Giovanni, N C Paladino, S Di Giovanni, N C Paladino, V Di Paola, C Raspanti, G I Melfa, F Cupido, S Mazzola, C Porrello, S Bonventre, G Gullotta
BACKGROUND: Patients undergoing thyroidectomy often complain aerodigestive disorders. In a previous study we showed the associations between voice impairment and proximal acid reflux, swallowing impairment and Upper Esophageal Sphyncter (UES) incoordination and the decrease in UES pressure in thirty-six patients observed before and soon afterwards uncomplicated thyroidectomy. This study investigated the state of post-thyroidectomy esophageal motility changes and its associations with these disorders after 18-24 months...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28004504/association-between-24-hour-combined-multichannel-intraluminal-impedance-ph-monitoring-and-symptoms-or-quality-of-life-in-patients-with-laryngopharyngeal-reflux
#7
S I Kim, O E Kwon, S Y Na, Y C Lee, J M Park, Y G Eun
OBJECTIVE: To evaluate the association between the parameters of 24-hour multichannel intraluminal impedance (MII)-pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (LPR) patients. DESIGN: Prospective cohort study without controls. SETTING: University teaching hospital. METHODS: Forty-five LPR patients were selected from subjects who underwent 24-hour MII-pH monitoring and were diagnosed with LPR from September 2014 to May 2015...
June 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27988066/laryngeal-mucosal-reaction-during-bronchial-histamine-challenge-test-visualized-by-videolaryngostroboscopy
#8
Maaria Ansaranta, Ahmed Geneid, Paula Kauppi, Leo Pekka Malmberg, Erkki Vilkman
OBJECTIVES/HYPOTHESIS: To examine the changes in the larynx, as well as self-reported voice and throat symptoms, among patients undergoing a histamine challenge test. Thus, to understand the possible clinical effects of histamine on the larynx. STUDY DESIGN: Controlled, open prospective study. METHODS: Thirty adult patients with prolonged cough and suspicion of bronchial asthma underwent a histamine challenge test. Videolaryngostroboscopy was performed immediately before and after the challenge...
December 14, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27928446/gastrostomy-with-peritoneal-collar-versus-percutaneous-endoscopic-gastrostomy
#9
COMPARATIVE STUDY
C Tudor, C Branescu, C Savlovschi, A El-Khatib, H Pantu, A Nica, A M Dascalu, B Masoumeh, A S Tudor, S M Oprescu, D Serban
Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted for a surgical solution for feeding. The indications, preoperative preparation, surgical techniques, and postoperative outcomes were analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27742492/accuracy-of-acoustic-analysis-measurements-in-the-evaluation-of-patients-with-different-laryngeal-diagnoses
#10
Leonardo Wanderley Lopes, Layssa Batista Simões, Jocélio Delfino da Silva, Deyverson da Silva Evangelista, Ana Celiane da Nóbrega E Ugulino, Priscila Oliveira Costa Silva, Vinícius Jefferson Dias Vieira
OBJECTIVE: This study aims to investigate the accuracy of acoustic measures in discriminating between patients with different laryngeal diagnoses. STUDY DESIGN: The study design is descriptive, cross-sectional, and retrospective. METHODS: A total of 279 female patients participated in the research. Acoustic measures of the mean and standard deviation (SD) values of the fundamental frequency (F0), jitter, shimmer, and glottal to noise excitation (GNE) were extracted from the emission of the vowel /ε/...
October 11, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27634013/characterization-and-mechanisms-of-the-pharyngeal-swallow-activated-by-stimulation-of-the-esophagus
#11
Ivan M Lang, Bidyut K Medda, Sudarshan R Jadcherla, Reza Shaker
Stimulation of the esophagus activates the pharyngeal swallow response (EPSR) in human infants and animals. The aims of this study were to characterize the stimulus and response of the EPSR and to determine the function and mechanisms generating the EPSR. Studies were conducted in 46 decerebrate cats in which pharyngeal, laryngeal, and esophageal motility was monitored using EMG, strain gauges, or manometry. The esophagus was stimulated by balloon distension or luminal fluid infusion. We found that esophageal distension increased the chance of occurrence of the EPSR, but the delay was variable...
November 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27500580/-differential-diagnostics-of-the-causes-responsible-for-a-cough-in-the-pregnant-women
#12
M A Ryabova, N A Shumilova, O V Lavrova, L V Pestakova, Yu S Fedotova
The objective of the present study was to elucidate the causes responsible for a cough in the pregnant women. It involved 92 patients including 23 ones presenting with bronchial asthma and 69 having no manifestations of asthma in their medical histories but suffering from dry cough that started after the beginning of pregnancy. All the patients were given counseling by the otorhinolaryngology and pulmonology specialists. The degree of endoscopic manifestations of gastroesophageal reflux was estimated based on a scoring scale...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27386809/velopharyngeal-incoordination-caused-by-phenytoin-induced-toxicity
#13
Chang Ho Hwang
Phenytoin induces lymphoid proliferation, resulting in complications that can range from tissue hyperplasia to lymphoma. Some of the complications resolve spontaneously after drug discontinuation. This report describes for the first time a case of dysphagia with lack of velopharyngeal coordination and nasopharyngeal reflux combined with massive palatine tonsillar hypertrophy. The condition did not develop before phenytoin administration, was induced by phenytoin, and spontaneously resolved upon drug discontinuation...
February 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27137439/unmet-needs-in-treating-laryngo-pharyngeal-reflux-disease-where-do-we-go-from-here
#14
REVIEW
Meera R Wright, Rohit Sharda, Michael F Vaezi
INTRODUCTION: Many patients experience ear, nose and throat symptoms associated with their gastroesophageal reflux disease. These symptoms are purportedly caused by reflux of gastroduodenal contents into the larynx, which leads to laryngopharyngeal reflux (LPR). Various modalities are used to diagnose LPR, including ambulatory pH monitoring, laryngoscopy, and esophagogastroduodenoscopy, as well as a few new emerging diagnostic tests. However, there are still no established diagnostic criteria or gold standard methodologies that can reliably distinguish LPR from other conditions...
September 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26945412/risk-of-esophageal-cancer-following-percutaneous-endoscopic-gastrostomy-in-head-and-neck-cancer-patients-a-nationwide-population-based-cohort-study-in-taiwan
#15
Kuen-Tze Lin, Chun-Shu Lin, Shih-Yu Lee, Wen-Yen Huang, Wei-Kuo Chang
Esophageal cancers account for majority of synchronous or metachronous head and neck cancers. This study examined the risk of esophageal cancer following percutaneous endoscopic gastrostomy (PEG) in head and neck cancer patients using the Taiwan National Health Insurance Research Database. From 1997 to 2010, we identified and analyzed 1851 PEG patients and 3702 sex-, age-, and index date-matched controls. After adjusting for esophagitis, esophagus stricture, esophageal reflux, and primary sites, the PEG cohort had a higher adjusted hazard ratio (2...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26687670/chronic-cough-as-a-symptom-of-laryngopharyngeal-reflux-two-case-reports
#16
Monika Kopka, Milena Małecka, Iwona Stelmach
Laryngopharyngeal reflux (LPR) is a complex of symptoms caused by the backflow of gastric contents into the larynx, pharynx, nasopharynx, sinuses and even to the middle ear space.The symptomatology of LPR includes: chronic cough, hoarseness, throat clearing, laryngitis,"globus pharyngeus", swallowing disturbances, postnasal drip, "fetor ex ore".In the article, the authors present two boys with chronic cough, in one of them the asthma was suspected and antiasthmatic treatment was administrated; in our patients according to the 24-hour pharyngeal pH-metry LPR was diagnosed...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/26673904/anatomic-and-physiopathologic-changes-affecting-the-airway-of-the-elderly-patient-implications-for-geriatric-focused-airway-management
#17
REVIEW
Kathleen N Johnson, Daniel B Botros, Leanne Groban, Yvon F Bryan
There are many anatomical, physiopathological, and cognitive changes that occur in the elderly that affect different components of airway management: intubation, ventilation, oxygenation, and risk of aspiration. Anatomical changes occur in different areas of the airway from the oral cavity to the larynx. Common changes to the airway include tooth decay, oropharyngeal tumors, and significant decreases in neck range of motion. These changes may make intubation challenging by making it difficult to visualize the vocal cords and/or place the endotracheal tube...
2015: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26509938/evaluation-of-pharyngeal-function-in-dogs-with-laryngeal-paralysis-before-and-after-unilateral-arytenoid-lateralization
#18
Natalia Andrade, Marc Kent, Elizabeth W Howerth, MaryAnn G Radlinsky
OBJECTIVE: To evaluate pharyngeal and laryngeal function using esophagography, topical pharyngeal/laryngeal sensitivity testing, and electromyography (EMG) in normal and dogs with idiopathic laryngeal paralysis (ILP) before and after unilateral arytenoid lateralization. STUDY: Prospective controlled cohort study. ANIMALS: Dogs with laryngeal paralysis (ILP; n = 8) and age/breed-matched (AB, n = 8) and young breed-matched dogs (B, n = 8) were recruited...
November 2015: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/26488535/adult-obstructive-sleep-apnoea-and-the-larynx
#19
REVIEW
Daniel Novakovic, Stuart MacKay
PURPOSE OF REVIEW: The review examines current evidence and thinking regarding the relationship between the larynx and obstructive sleep apnoea (OSA) in adults. RECENT FINDINGS: Drug-induced sleep endoscopy has an emerging role in the identification of laryngeal obstruction associated with sleep apnoea and may be adjunctive to awake dynamic assessment in specific cases. Nocturnal stridor and OSA is a common and treatable finding in patients with multiple system atrophy...
December 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/26439546/op-5-interobserver-validity-of-the-reflux-finding-score-for-infants-rfs-i-in-flexible-versus-rigid-laryngoscopy
#20
Mmj Singendonk, B Pullens, Jaa van Heteren, Hhw de Gier, H J Hoeve, A M König-Jung, M P van der Schroeff, Cel Hoekstra, L L Veder, R J van der Pol, M A Benninga, M P van Wijk
BACKGROUND: The Reflux Finding Score for Infants (RFS-I) was developed to objectively assess signs of laryngopharyngeal reflux (LPR). Based on review of flexible laryngoscopic videos, only moderate inter- and highly variable intraobserver reliability was found. We hypothesized that examination of the infant larynx with rigid laryngoscopy would provide better agreement. AIM: to assess the validity of the RFS-I in the detection of LPR-related findings using flexible versus rigid laryngoscopy...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
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