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Cardiovascular imaging

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https://www.readbyqxmd.com/read/29242239/defining-quality-in-cardiovascular-imaging-a-scientific-statement-from-the-american-heart-association
#1
REVIEW
Leslee J Shaw, Ron Blankstein, Jill E Jacobs, Jonathon A Leipsic, Raymond Y Kwong, Viviany R Taqueti, Rob S B Beanlands, Jennifer H Mieres, Scott D Flamm, Thomas C Gerber, John Spertus, Marcelo F Di Carli
The aims of the current statement are to refine the definition of quality in cardiovascular imaging and to propose novel methodological approaches to inform the demonstration of quality in imaging in future clinical trials and registries. We propose defining quality in cardiovascular imaging using an analytical framework put forth by the Institute of Medicine whereby quality was defined as testing being safe, effective, patient-centered, timely, equitable, and efficient. The implications of each of these components of quality health care are as essential for cardiovascular imaging as they are for other areas within health care...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29241460/fractal-analysis-of-left-ventricular-trabeculations-is-associated-with-impaired-myocardial-deformation-in-healthy-chinese
#2
Jiashen Cai, Jennifer Ann Bryant, Thu-Thao Le, Boyang Su, Antonio de Marvao, Declan P O'Regan, Stuart A Cook, Calvin Woon-Loong Chin
BACKGROUND: Left ventricular (LV) non-compaction (LVNC) is defined by extreme LV trabeculation, but is measured variably. Here we examined the relationship between quantitative measurement in LV trabeculation and myocardial deformation in health and disease and determined the clinical utility of semi-automated assessment of LV trabeculations. METHODS: Cardiovascular magnetic resonance (CMR) was performed in 180 healthy Singaporean Chinese (age 20-69 years; males, n = 91), using balanced steady state free precession cine imaging at 3T...
December 14, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29239886/acute-coronary-artery-dissection-a-review-of-the-literature-and-current-evidence
#3
Syed Raza Shah, Richard Alweis
Acute coronary artery dissection is a rare, complex disease occurring particularly in young women without traditional cardiovascular risk factors. The pathophysiology and treatment are different from acute coronary syndrome caused by plaque rupture or erosion. Its clinical presentation may vary from unstable angina to sudden cardiac death. Hence, early detection is crucial to manage the dissection and reduce the mortality and morbidity rates. Most coronary dissections will heal spontaneously, and conservative treatment is recommended for uncomplicated cases...
December 12, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29239351/association-of-serum-uric-acid-levels-with-osteoporosis-and-bone-turnover-markers-in-a-chinese-population
#4
Dan-Dan Yan, Jie Wang, Xu-Hong Hou, Yu-Qian Bao, Zhen-Lin Zhang, Cheng Hu, Wei-Ping Jia
Recent evidence shows that uric acid is protective against some neurological diseases, but can be detrimental in many metabolic and cardiovascular disorders. In this study, we examined the association between serum uric acid levels and bone metabolism in Chinese males and postmenopausal females. A total of 943 males and 4256 postmenopausal females were recruited in Shanghai. The levels of serum uric acid and bone turnover markers (BTMs) were detected along with other biochemical traits. In addition, the fat distribution was calculated through MRI and image analysis software, and bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29239331/ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-are-risk-factors-for-ischemic-stroke-in-patients-with-type-2-diabetes
#5
Ting Li, Xiu-Juan Wu, Xiao-Min Chen, Si-Bo Wang, Kang-Ding Liu, Ying-Qi Xing
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity (BaPWV) and ankle-brachial index (ABI) are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group (n = 55) and a diabetes and ischemic stroke group (n = 62)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239134/recent-advances-in-managing-atherosclerosis-via-nanomedicine
#6
REVIEW
Cecilia Ka Wing Chan, Lei Zhang, Chak Kwong Cheng, Hongrong Yang, Yu Huang, Xiao Yu Tian, Chung Hang Jonathan Choi
Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the blood vessel wall, underpins many cardiovascular diseases with high mortality rates globally, such as stroke and ischemic heart disease. Engineered bio-nanomaterials are now under active investigation as carriers of therapeutic and/or imaging agents to atherosclerotic plaques. This Review summarizes the latest bio-nanomaterial-based strategies for managing atherosclerosis published over the past five years, a period marked by a rapid surge in preclinical applications of bio-nanomaterials for imaging and/or treating atherosclerosis...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29238826/a-re-engineered-software-interface-and-workflow-for-the-open-source-simvascular-cardiovascular-modeling-package
#7
Hongzhi Lan, Adam Updegrove, Nathan Wilson, Gabriel D Maher, Shawn C Shadden, Alison Marsden
Patient-specific simulation plays an important role in cardiovascular disease research, diagnosis, surgical planning and medical device design, as well as education in cardiovascular biomechanics. SimVascular is an open-source software package encompassing an entire cardiovascular modeling and simulation pipeline from image segmentation, 3D solid modeling, and mesh generation, to patient-specific simulation and analysis. SimVascular is widely used for cardiovascular basic science and clinical research as well as education, following increased adoption by users and development of a GATEWAY web portal to facilitate educational access...
December 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29238728/retinal-photoreceptors-and-microvascular-changes-in-prediabetes-measured-with-adaptive-optics-rtx1%C3%A2-a-case-control-study
#8
Anna Zaleska-Żmijewska, Paweł Piątkiewicz, Barbara Śmigielska, Anna Sokołowska-Oracz, Zbigniew M Wawrzyniak, Dorota Romaniuk, Jerzy Szaflik, Jacek P Szaflik
Background: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. Objective: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29237609/diagnosis-and-prognosis-in-sudden-cardiac-arrest-survivors-without-coronary-artery-disease-utility-of-a-clinical-approach-using-cardiac-magnetic-resonance-imaging
#9
Patricia Rodrigues, Abhishek Joshi, Howell Williams, Mark Westwood, Steffen E Petersen, Filip Zemrak, Richard J Schilling, Claire Kirkby, Andrew Wragg, Charlotte Manisty, Saidi Mohiddin
BACKGROUND: Determining the pathogenesis of sudden cardiac arrest or periarrest without significant coronary artery disease is crucial for management and prognosis. Cardiovascular magnetic resonance (CMR) can detect morphological, functional, or tissue abnormalities, and we sought to evaluate the role of CMR in determining sudden cardiac arrest pathogenesis and prognosis in survivors. METHODS AND RESULTS: We retrospectively reviewed cardiac investigations and clinical outcomes in consecutive survivors of potentially fatal arrhythmias without coronary artery disease admitted to our institutions from 2008 to 2014...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29237156/potential-involvement-of-mir-30e-3p-in-myocardial-injury-induced-by-coronary-microembolization-via-autophagy-activation
#10
Xian-Tao Wang, Xiao-Dan Wu, Yuan-Xi Lu, Yu-Han Sun, Han-Hua Zhu, Jia-Bao Liang, Wen-Kai He, Zhi-Yu Zeng, Lang Li
BACKGROUND/AIMS: Coronary microembolization (CME) can lead to no-reflow or slow reflow, which is one of the important reasons for loss of clinical benefit from myocardial reperfusion therapy. MicroRNAs and autophagy are heavily implicated in the occurrence and development of almost all cardiovascular diseases. Therefore, the present study was designed to investigate the role of miR-30e-3p and autophagy in CME-induced myocardial injury rat model. METHODS: Sixty rats were randomly divided into six groups: sham, CME 1h,3h,6h,9h, and 12h (n = 10 per group)...
December 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29236978/impact-of-the-2016-ase-eacvi-recommendations-on-the-prevalence-of-diastolic-dysfunction-in-the-general-population
#11
João G Almeida, Ricardo Fontes-Carvalho, Francisco Sampaio, José Ribeiro, Paulo Bettencourt, Frank A Flachskampf, Adelino Leite-Moreira, Ana Azevedo
Aims: Diastolic dysfunction (DD) is frequent in the general population; however, the assessment of diastolic function remains challenging. We aimed to evaluate the impact of the recent 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) recommendations in the prevalence and grades of DD compared with the 2009 guidelines and the Canberra Study Criteria (CSC). Methods and results: Within a population-based cohort, a total of 1000 individuals, aged ≥45 years, were evaluated retrospectively...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236892/joinville-stroke-biobank-study-protocol-and-first-year-s-results
#12
Leslie Ecker Ferreira, Paulo Henrique Condeixa de França, Vivian Nagel, Vanessa Venancio, Juliana Safanelli, Felipe Ibiapina Dos Reis, Luis Furtado, Rui Kleber Martins, Gustavo Weiss, Elder Oda, Iscia Lopes-Cendes, Octavio Pontes-Neto, Norberto Luiz Cabral
Aiming to contribute to studies that use detailed clinical and genomic information of biobanks, we present the initial results of the first Latin American Stroke Biobank. METHODS: Blood samples were collected from patients included in the Joinville Stroke Registry and four Brazilian cities. Demographic socio-economic data, cardiovascular risk factors, Causative Classification System for Ischemic Stroke, Trial of Org 10172 in Acute Stroke Treatment and National Institutes of Health scores, functional stroke status (modified Rankin) and brain images were recorded...
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29236169/current-treatment-of-central-retinal-artery-occlusion-a-national-survey
#13
Teddy S Youn, Patrick Lavin, Morgan Patrylo, Joseph Schindler, Howard Kirshner, David M Greer, Matthew Schrag
BACKGROUND: Central retinal artery occlusion (CRAO) is an ophthalmological emergency, the retinal analog of a stroke. To date there is no consensus or national guidelines on how this disorder should be managed. As academic neurologists and ophthalmologists treat CRAO frequently, we set out to understand how these clinicians approach patients with CRAO with a national survey. METHODS: We identified university-associated teaching hospitals offering vascular neurology, neuro-ophthalmology and/or retina fellowships in the US and asked the directors of the programs to respond to questions in an open response format to profile the acute management of CRAO at their institution...
December 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29235722/alterations-in-ventricular-pumping-in-patients-with-atrial-septal-defect-at-rest-during-dobutamine-stress-and-after-defect-closure
#14
Sigurdur S Stephensen, Ellen Ostenfeld, Katarina Steding-Ehrenborg, Ulf Thilén, Einar Heiberg, Hakan Arheden, Marcus Carlsson
BACKGROUND: Regional ventricular pumping mechanisms in patients with volume-loaded right ventricles (RV) are altered, but the cause is unknown. The aim was to determine whether these changes in ventricular pumping mechanisms are influenced by the RV dilatation itself or the aetiology behind it. METHODS: Seventeen patients with atrial septal defects (ASD) and 10 healthy controls underwent cardiovascular magnetic resonance (CMR) at rest and during dobutamine/atropine stress...
December 13, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29235436/bioprosthetic-aortic-valve-leaflet-thrombosis-detected-by-multidetector-computed-tomography-is-associated-with-adverse-cerebrovascular-events-a-meta-analysis-of-observational-studies
#15
Hashrul N Rashid, Robert P Gooley, Nitesh Nerlekar, Abdul R Ihdayhid, Liam M McCormick, Arthur Nasis, James D Cameron, Adam J Brown
AIMS: Leaflet thrombosis (LT) has become increasingly recognised following transcatheter and surgical aortic ABV replacement and can be reliably identified by MDCT. However, it is ongoing debate whether MDCT-defined LT is associated with adverse cerebrovascular outcomes. We performed a systematic review and meta-analysis to assess the incidence and clinical outcomes associated with multidetector computed tomography (MDCT)-defined leaflet thrombosis following aortic bioprosthetic valve (ABV) replacement...
December 12, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29234935/cardiac-and-respiratory-gated-volumetric-murine-ultrasound
#16
Arvin H Soepriatna, Frederick W Damen, Pavlos P Vlachos, Craig J Goergen
Current cardiovascular ultrasound mainly employs planar imaging techniques to assess function and physiology. These techniques rely on geometric assumptions, which are dependent on the imaging plane, susceptible to inter-observer variability, and may be inaccurate when studying complex diseases. Here, we developed a gated volumetric murine ultrasound technique to visualize cardiovascular motion with high spatiotemporal resolution and directly evaluate cardiovascular health. Cardiac and respiratory-gated cine loops, acquired at 1000 frames-per-second from sequential positions, were temporally registered to generate a four-dimensional (4D) dataset...
December 12, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29234351/space-and-time-resolved-detection-of-platelet-activation-and-von-willebrand-factor-conformational-changes-in-deep-suspensions
#17
Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A Gilad, Thomas S Kickler, Tobias Obser, Zaverio M Ruggeri, Joseph Katz
Tracking cells and proteins' phenotypic changes in deep suspensions is critical for the direct imaging of blood-related phenomena in in vitro replica of cardiovascular systems and blood-handling devices. This paper introduces fluorescence imaging techniques for space and time resolved detection of platelet activation, von Willebrand factor (VWF) conformational changes, and VWF-platelet interaction in deep suspensions. Labeled VWF, platelets, and VWF-platelet strands are suspended in deep cuvettes, illuminated, and imaged with a high-sensitivity EM-CCD camera, allowing detection using an exposure time of 1 ms...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/29233624/first-and-second-trimester-screening-for-fetal-structural-anomalies
#18
REVIEW
Lindsay Edwards, Lisa Hui
Fetal structural anomalies are found in up to 3% of all pregnancies and ultrasound-based screening has been an integral part of routine prenatal care for decades. The prenatal detection of fetal anomalies allows for optimal perinatal management, providing expectant parents with opportunities for additional imaging, genetic testing, and the provision of information regarding prognosis and management options. Approximately one-half of all major structural anomalies can now be detected in the first trimester, including acrania/anencephaly, abdominal wall defects, holoprosencephaly and cystic hygromata...
December 9, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29231948/a-tailored-nanosheet-decorated-with-a-metallized-dendrimer-for-angiography-and-magnetic-resonance-imaging-guided-combined-chemotherapy
#19
Guilong Zhang, Ruohong Du, Junchao Qian, Xiaojia Zheng, Xiaohe Tian, Dongqing Cai, Jiacai He, Yiqun Wu, Wei Huang, Yuanyin Wang, Xin Zhang, Kai Zhong, Duohong Zou, Zhengyan Wu
Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising gadolinium conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis and imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide conjugated with a folic acid- and gadolinium-labeled dendrimer (FA-GCGLD) to boost its T1 contrast ability was developed, and doxorubicin (DOX) and colchicine (COLC) were efficiently loaded onto this nanosystem (FA-GCGLD-DOX/COLC)...
December 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/29231290/cardiovascular-magnetic-resonance-imaging-and-clinical-performance-of-somatostatin-receptor-positron-emission-tomography-in-cardiac-sarcoidosis
#20
Carmen Pizarro, Folke Kluenker, Darius Dabir, Daniel Thomas, Florian C Gaertner, Markus Essler, Christian Grohé, Georg Nickenig, Dirk Skowasch
AIMS: Cardiac affection constitutes a major limiting condition in systemic sarcoidosis. The primary objective of this study was to investigate the persistence rate of cardiac sarcoid involvement by cardiovascular magnetic resonance (CMR) imaging in patients diagnosed with cardiac sarcoidosis (CS). Moreover, we examined the additional insights into myocardial damage's characteristics gained by somatostatin receptor scintigraphy. METHODS AND RESULTS: In a pilot study, we had previously identified cardiac involvement-diagnosed by CMR imaging-to be present in 29 of 188 patients (15...
December 12, 2017: ESC Heart Failure
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