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Cardiovascular imaging

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https://www.readbyqxmd.com/read/29908471/searching-for-synergistic-calcium-antagonists-and-novel-therapeutic-regimens-for-coronary-heart-disease-therapy-from-a-traditional-chinese-medicine-suxiao-jiuxin-pill
#1
Wei Lei, Jianan Ni, Xueting Xia, Min Jiang, Gang Bai
Coronary heart disease is a vital cause of morbidity and mortality worldwide, and calcium channel blockers (CCBs) are important drugs that can be used to treat cardiovascular diseases. Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, is widely used as an emergency drug for coronary heart disease therapy. However, understanding its potential mechanism in intracellular calcium concentration ([Ca2+ ]i ) modulation remains a challenge. To identify the active pharmacological ingredients (APIs) and reveal a novel combination therapy for ameliorating cardiovascular diseases, the ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) combined with a dual-luciferase reporter [Ca2+ ]i assay system was applied...
June 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29907089/temporarily-increased-stroke-rate-after-takotsubo-syndrome-need-for-an-anticoagulation
#2
Nadine Abanador-Kamper, Lars Kamper, Judith Wolfertz, Marc Vorpahl, Patrick Haage, Melchior Seyfarth
BACKGROUND: Previous studies have reported slightly higher stroke rates in Takotsubo Syndrome compared to acute myocardial infarction. Our goal was to evaluate the temporal course of stroke rates and left ventricular recovery in patients with Takotsubo Syndrome. METHODS: We retrospectively examined the clinical and imaging data of 72 patients with Takotsubo Syndrome. The data collected came from January 2005 to March 2017. Left ventricular performance was evaluated by cardiovascular magnetic resonance imaging (MRI) in all patients during the acute phase of Takotsubo Syndrome and in a follow-up scan 2 months later...
June 15, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29905776/criteria-for-recommendation-expert-consensus-and-appropriateness-criteria-papers-update-from-the-european-association-of-cardiovascular-imaging-scientific-documents-committee
#3
Victoria Delgado, Nuno Cardim, Bernard Cosyns, Erwan Donal, Frank Flachskampf, Maurizio Galderisi, Bernhard Gerber, Alessia Gimelli, Kristina H Haugaa, Philipp A Kaufmann, Patrizio Lancellotti, Julien Magne, Pier Giorgio Masci, Denisa Muraru, Gilbert Habib, Thor Edvardsen, Bogdan A Popescu
No abstract text is available yet for this article.
June 13, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29903689/interplay-between-epicardial-adipose-tissue-metabolic-and-cardiovascular-diseases
#4
Olga Bornachea, Angela Vea, Vicenta Llorente-Cortes
Cardiovascular disease is the primary cause of death in obese and diabetic patients. In these groups of patients, the alterations of epicardial adipose tissue (EAT) contribute to both vascular and myocardial dysfunction. Therefore, it is of clinical interest to determine the mechanisms by which EAT influences cardiovascular disease. Two key factors contribute to the tight intercommunication among EAT, coronary arteries and myocardium. One is the close anatomical proximity between these tissues. The other is the capacity of EAT to secrete cytokines and other molecules with paracrine and vasocrine effects on the cardiovascular system...
June 11, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29902554/resource-use-during-the-last-6-months-of-life-among-copd-patients-a-population-level-study
#5
Kristof Faes, Joachim Cohen, Lieven Annemans
CONTEXT: Chronic obstructive pulmonary disease (COPD) patients often have several comorbidities, such as cardiovascular diseases (CVD) or lung cancer (LC), which might influence resource use in the final months of life. However, no previous studies documented resource use in end-of-life COPD patients at a population level, thereby differentiating whether COPD patients die of their COPD, CVD or LC. AIM: To describe end-of-life resource use in people diagnosed with COPD and compare this resource use between those dying of COPD, CVD and LC...
June 11, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29902198/intimal-and-medial-arterial-changes-defined-by-ultra-high-frequency-ultrasound-response-to-changing-risk-factors-in-children-with-chronic-kidney-disease
#6
Frida Dangardt, Marietta Charakida, Scott Chiesa, Devina Bhowruth, Alicja Rapala, Daniela Thurn, Franz Schaefer, John Deanfield, Rukshana Shroff
BACKGROUND: Patients with chronic kidney disease (CKD) are exposed to both traditional 'Framingham' and uremia related cardiovascular risk factors that drive atherosclerotic and arteriosclerotic disease, but these cannot be differentiated using conventional ultrasound. We used ultra-high-frequency ultrasound (UHFUS) to differentiate medial thickness (MT) from intimal thickness (IT) in CKD patients, identify their determinants and monitor their progression. METHODS: Fifty-four children and adolescents with CKD and 12 healthy controls underwent UHFUS measurements using 55-70MHz transducers in common carotid and dorsal pedal arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29901448/additional-value-of-three-dimensional-rotational-angiography-in-the-diagnostic-evaluation-and-percutaneous-treatment-of-children-with-univentricular-hearts
#7
Femke van der Stelt, Gregor J Krings, Mirella C Molenschot, Johannes M Breur
AIMS: Complex single ventricle topography, changes in vessel geometry after surgical steps and subsequent stenoses are difficult to visualise with biplane conventional angiography (CA). This study investigated the additional value of three-dimensional rotational angiography (3DRA) compared to CA for diagnostic and interventional purposes in children with univentricular hearts. METHODS AND RESULTS: Demographic data, clinical data and catheterisation details of both imaging techniques were collected retrospectively...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29899591/3d-printed-cardiovascular-patient-specific-phantoms-used-for-clinical-validation-of-a-ct-derived-ffr-diagnostic-software
#8
Kelsey N Sommer, Lauren Shepard, Nitant Vivek Karkhanis, Vijay Iyer, Erin Angel, Michael F Wilson, Frank J Rybicki, Dimitrios Mitsouras, Stephen Rudin, Ciprian N Ionita
Purpose: 3D printed patient specific vascular models provide the ability to perform precise and repeatable benchtop experiments with simulated physiological blood flow conditions. This approach can be applied to CT-derived patient geometries to determine coronary flow related parameters such as Fractional Flow Reserve (FFR). To demonstrate the utility of this approach we compared bench-top results with non-invasive CT-derived FFR software based on a computational fluid dynamics algorithm and catheter based FFR measurements...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29898740/prognostic-value-of-myocardial-strain-and-late-gadolinium-enhancement-on-cardiovascular-magnetic-resonance-imaging-in-patients-with-idiopathic-dilated-cardiomyopathy-with-moderate-to-severely-reduced-ejection-fraction
#9
Seung-Hoon Pi, Sung Mok Kim, Jin-Oh Choi, Eun Kyoung Kim, Sung-A Chang, Yeon Hyeon Choe, Sang-Chol Lee, Eun-Seok Jeon
BACKGROUND: It has been reported that left ventricular (LV) myocardial strain and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging have prognostic value in patients with heart failure (HF). However, previous studies included patients with various systolic functions. This study aimed to investigate the prognostic value of LV myocardial strain and LGE on CMR imaging in patients with idiopathic dilated cardiomyopathy (DCM) with reduced ejection fraction (EF < 40%)...
June 14, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29898736/3d-whole-brain-vessel-wall-cardiovascular-magnetic-resonance-imaging-a-study-on-the-reliability-in-the-quantification-of-intracranial-vessel-dimensions
#10
Na Zhang, Fan Zhang, Zixin Deng, Qi Yang, Marcio A Diniz, Shlee S Song, Konrad H Schlick, M Marcel Maya, Nestor Gonzalez, Debiao Li, Hairong Zheng, Xin Liu, Zhaoyang Fan
BACKGROUND: One of the potentially important applications of three-dimensional (3D) intracranial vessel wall (IVW) cardiovascular magnetic resonance (CMR) is to monitor disease progression and regression via quantitative measurement of IVW morphology during medical management or drug development. However, a prerequisite for this application is to validate that IVW morphologic measurements based on the modality are reliable. In this study we performed comprehensive reliability analysis for the recently proposed whole-brain IVW CMR technique...
June 14, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29897880/cardiovascular-assessment-by-imaging-photoplethysmography-a-review
#11
Sebastian Zaunseder, Alexander Trumpp, Daniel Wedekind, Hagen Malberg
Over the last few years, the contactless acquisition of cardiovascular parameters using cameras has gained immense attention. The technique provides an optical means to acquire cardiovascular information in a very convenient way. This review provides an overview on the technique's background and current realizations. Besides giving detailed information on the most widespread application of the technique, namely the contactless acquisition of heart rate, we outline further concepts and we critically discuss the current state...
June 13, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29896711/hemodynamic-studies-for-analyzing-the-teratogenic-effects-of-drugs-in-the-zebrafish-embryo
#12
Huseyin C Yalcin
Investigations of teratogenic effects of drugs generally involve testing the drug on animals and zebrafish embryo is a commonly used animal model for that purpose. In these studies, cardiovascular function of the animals needs to be evaluated to reveal the influence of exposure on the development of the cardiovascular system as well as on the growth of the whole animal. Here, relevant microscopy imaging and analysis protocols are described to calculate a variety of hemodynamic parameters for zebrafish embryos exposed to clinical drugs...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29895299/association-between-abdominal-adiposity-and-subclinical-measures-of-left-ventricular-remodeling-in-diabetics-prediabetics-and-normal-controls-without-history-of-cardiovascular-disease-as-measured-by-magnetic-resonance-imaging-results-from-the-kora-ff4-study
#13
Christopher L Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, Jürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters, Fabian Bamberg
OBJECTIVES: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states. METHODS: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29894585/radiation-safety-with-dose-reduction-technology-the-buck-stops-at-zero-dose
#14
EDITORIAL
Vigyan V Bang, Michael S Levy
Exposure to ionizing radiation in cardiovascular imaging and its adverse impact on health is a growing concern. Cath lab imaging dose-reduction technology is an effective way to reduce patient and operator radiation dose. More clinical trials and studies such as this one are needed to assess the short-and long-term impact of this important technology.
June 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29893297/18f-fluorodeoxyglucose-positron-emission-tomography-based-evaluation-of-systemic-and-vascular-inflammation-and-assessment-of-the-effect-of-systemic-treatment-on-inflammation-in-patients-with-moderate-to-severe-psoriasis-a-randomized-placebo-controlled-pilot
#15
Sharonjeet Kaur, Nusrat Shafiq, Sunil Dogra, B R Mittal, Savita Verma Attri, Ajay Bahl, Tarun Narang, Keshavamurthy Vinay, Sujit Rajagopalan, Samir Malhotra
Background: Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Objective: To evaluate the utility of [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography in identifying vascular and systemic inflammation in psoriasis patients with moderate-to-severe disease and to analyze its usefulness in assessing the effect of systemic treatment. Methods: This was a randomized, double-blind pilot study conducted in a tertiary care center...
June 8, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29891737/reduced-myocardial-flow-reserve-by-positron-emission-tomography-predicts-cardiovascular-events-after-cardiac-transplantation
#16
Matthew C Konerman, John J Lazarus, Richard L Weinberg, Ravi V Shah, Michael Ghannam, Scott L Hummel, James R Corbett, Edward P Ficaro, Keith D Aaronson, Monica M Colvin, Todd M Koelling, Venkatesh L Murthy
BACKGROUND: We evaluated the diagnostic and prognostic value of quantification of myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart transplant patients. METHODS AND RESULTS: We retrospectively identified orthotopic heart transplant patients who underwent rubidium-82 cardiac PET imaging. The primary outcome was the composite of cardiovascular death, acute coronary syndrome, coronary revascularization, and heart failure hospitalization...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29890445/evidence-of-aortic-dissection-and-marfan-syndrome-in-a-mummy-from-the-capuchin-catacombs-of-palermo-sicily
#17
Stephanie Panzer, Randall C Thompson, Klaus Hergan, Albert R Zink, Dario Piombino-Mascali
The authors report on the assessment of an anthropogenic mummy of a young man from the Capuchin Catacombs of Palermo, Sicily, tentatively dated from the mid- to late 19th century AD. The mummy was investigated by full-body CT examination. CT images clearly showed aortic dissection classified as Stanford-A. Due to the relation of aortic dissection to inherited connective tissue diseases in young people, such as Marfan syndrome, conspicuous and pathological findings possibly indicating the presence of underlying Marfan syndrome were assessed...
June 8, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29889193/metabolic-mapping-quantitative-enzyme-cytochemistry-and-histochemistry-to-determine-the-activity-of-dehydrogenases-in-cells-and-tissues
#18
Remco J Molenaar, Mohammed Khurshed, Vashendriya V V Hira, Cornelis J F Van Noorden
Altered cellular metabolism is a hallmark of many diseases, including cancer, cardiovascular diseases and infection. The metabolic motor units of cells are enzymes and their activity is heavily regulated at many levels, including the transcriptional, mRNA stability, translational, post-translational and functional level. This complex regulation means that conventional quantitative or imaging assays, such as quantitative mRNA experiments, Western Blots and immunohistochemistry, yield incomplete information regarding the ultimate activity of enzymes, their function and/or their subcellular localization...
May 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29888621/the-relationship-between-aspirin-resistance-and-carotid-imaging-in-young-patients-with-st-segment-elevated-myocardial-infarction-a-cross-sectional-study
#19
Mustafa Umut Somuncu, Ali Riza Demir, Huseyin Karakurt, Nail Guven Serbest, Belma Kalayci, Umit Bulut, Seda Tukenmez Karakurt
The presence of carotid atherosclerosis accompanied by coronary artery disease is associated with poor prognosis. A subset of patients who take aspirin continue to have recurrent cardiovascular events, which may be due to aspirin resistance (AR). Also, carotid plaques may cause turbulent flow which in turn may lead to platelet activation and poor antiplatelet response. In our study, we aimed to show the prevalence of AR and its relationship between high-risk carotid images in young patients with ST-segment elevated myocardial infarction (STEMI)...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29886750/can-incidental-vascular-calcifications-at-mammography-be-used-as-a-screening-biomarker-for-heart-and-kidney-disease
#20
Damla Erbil, Emine M Onal, Cagri Demirel, Alan A Sag, Tuncay Dagel, Baris Afsar, Adrian Covic, Mehmet Kanbay
Mammography is a screening test with extensive international application and financial infrastructure promoting accessibility and affordability. Designed specifically to detect microcalcifications, mammography is powered to detect calcifications in vessel walls. Breast arterial calcifications (BAC) are one of the most common incidental findings documented by mammography. This review considers the literature regarding BAC in relation to cardiovascular disease (CVD) and its risk factors. The aim is to assess the possibility of using BAC as an early surrogate imaging biomarker of CVD...
January 1, 2018: Angiology
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