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https://www.readbyqxmd.com/read/28927320/stress-and-cortisol-responses-in-men-differences-according-to-facial-symmetry
#1
Javier I Borráz-León, Ana Lilia Cerda-Molina, Lilian Mayagoitia-Novales
Stress response is associated with increased activity in the hypothalamic-pituitary-adrenocortical axis. Chronic stress-induced elevation in cortisol may alter its own negative regulation with multiple long-term consequences for physical and psychological health. One of the most reliable physical traits associated with mental, apparent physical health, and competitiveness is the degree of facial fluctuating asymmetry. However, to our knowledge there are no studies regarding the relationship between cortisol levels, facial symmetry and male competitiveness, and how cortisol changes after a stressful test depending on these traits...
September 19, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28926562/generics-for-the-treatment-of-hepatitis-c-in-monoinfected-and-hiv-coinfected-patients-pros-and-cons
#2
Dario Cattaneo, Alessandro Fossati, Chiara Resnati, Massimo Galli, Cristina Gervasoni
The treatment of hepatitis C virus in monoinfected and HIV-coinfected patients has greatly changed over recent years as a result of the introduction of direct-acting antiviral agents (DAAs), which have revolutionized clinical outcomes and led to sustained virological response rates above 90-95%. The discovery of new molecules and the subsequent competition between pharmaceutical companies, together with the negotiated price policies pursued by many national health systems, have led to a gradual reduction in the cost of DAAs, and expand their use to an increasing number of patients, including those with mild liver damage...
September 19, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28922647/the-self-survives-extinction-self-association-biases-attention-in-patients-with-visual-extinction
#3
Jie Sui, Glyn W Humphreys
People show biases to self-related information on a range of tasks. Key but controversial questions are whether self-related information is processed without attention, and whether self-related information determines what is attended. We examined this using patients showing visual extinction. We had patients associated shapes with themselves or their best friend prior to carrying out a shape identification task. We demonstrate that extinction was modulated by whether patients associated stimuli with themselves or their best friend...
August 16, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28921784/the-evolution-of-gonad-expenditure-and-gonadosomatic-index-gsi-in-male-and-female-broadcast-spawning-invertebrates
#4
Geoff A Parker, Steven A Ramm, Jussi Lehtonen, Jonathan M Henshaw
Sedentary broadcast-spawning marine invertebrates, which release both eggs and sperm into the water for fertilization, are of special interest for sexual selection studies. They provide unique insight into the early stages of the evolutionary succession leading to the often-intense operation of both pre- and post-mating sexual selection in mobile gonochorists. Since they are sessile or only weakly mobile, adults can interact only to a limited extent with other adults and with their own fertilized offspring...
September 18, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28914222/process-measures-or-patient-reported-experience-measures-prems-for-comparing-performance-across-providers-a-study-of-measures-related-to-access-and-continuity-in-swedish-primary-care
#5
Anna H Glenngård, Anders Anell
Aim To study (a) the covariation between patient reported experience measures (PREMs) and registered process measures of access and continuity when ranking providers in a primary care setting, and (b) whether registered process measures or PREMs provided more or less information about potential linkages between levels of access and continuity and explaining variables. BACKGROUND: Access and continuity are important objectives in primary care. They can be measured through registered process measures or PREMs...
September 15, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28914172/effects-of-pharmacological-inhibition-of-plasminogen-binding-on-liver-regeneration-in-rats
#6
Atsushi Miura, Kyoko Ishiguro, Kouta Koizumi, Yuki Yaita, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki
The fibrinolysis system is thought to play an important role in liver regeneration. We previously found that plasminogen (Plg) is localized to the cell surface of regenerating liver tissue as well as proliferating hepatocytes in vitro. Here, we investigated the significance of Plg binding to the cell surface during liver regeneration. Pre-administration of tranexamic acid (TXA), which is a competitive inhibitor of Plg binding, to hepatectomized rats mildly delayed restoration of liver weight in vivo. Although binding of Plg to the cell membrane decreased following TXA administration, TXA showed little effect on hepatocyte proliferation in rats...
September 15, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28912697/brains-in-competition-improved-cognitive-performance-and-inter-brain-coupling-by-hyperscanning-paradigm-with-functional-near-infrared-spectroscopy
#7
Michela Balconi, Maria E Vanutelli
Hyperscanning brain paradigm was applied to competitive task for couples of subjects. Functional Near-Infrared Spectroscopy (fNIRS) and cognitive performance were considered to test inter-brain and cognitive strategy similarities between subjects (14 couples) during a joint-action. We supposed increased brain-to-brain coupling and improved cognitive outcomes due to joint-action and the competition. As supposed, the direct interaction between the subjects and the observed external feedback of their performance (an experimentally induced fictitious feedback) affected the cognitive performance with decreased Error Rates (ERs), and Response Times (RTs)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28904013/integrative-analysis-of-rna-polymerase-ii-and-transcriptional-dynamics-upon-myc-activation
#8
Stefano de Pretis, Theresia R Kress, Marco J Morelli, Arianna Sabò, Chiara Locarno, Alessandro Verrecchia, Mirko Doni, Stefano Campaner, Bruno Amati, Mattia Pelizzola
Overexpression of the MYC transcription factor causes its widespread interaction with regulatory elements in the genome but leads to the up- and down-regulation of discrete sets of genes. The molecular determinants of these selective transcriptional responses remain elusive. Here, we present an integrated time-course analysis of transcription and mRNA dynamics following MYC activation in proliferating mouse fibroblasts, based on chromatin immunoprecipitation, metabolic labeling of newly synthesized RNA, extensive sequencing, and mathematical modeling...
September 13, 2017: Genome Research
https://www.readbyqxmd.com/read/28903911/a-visual-multiplex-pcr-microchip-with-easy-sample-loading
#9
Jian-Wei Chen, Ning Shao, Yuchen Zhang, Yuanshou Zhu, Litao Yang, Sheng-Ce Tao
There is an urgent demand for affordable, rapid and easy-to-use technology to simultaneously detect many different DNA targets within one reaction. Conventional multiplex PCR is an effective methodology to simultaneously amplify different DNA targets. However, its multiplicity is limited due to the intrinsic interference and competition among primer pairs within one tube. Here, we present an easy multiplex PCR microchip system, which can simultaneously detect 54 targets. The design of the microchip is quite simple...
June 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28902112/the-efficacy-of-repeated-cold-water-immersion-on-recovery-following-a-simulated-rugby-union-protocol
#10
Sean Barber, Pattison John, Freddy Brown, Jessica Hill
Training and athletic competition frequently results in exercise induced muscle damage (EIMD). The purpose of this study was to investigate the efficacy of repeated cold water immersion (CWI) on recovery following a simulated rugby union match. Sixteen male, club level rugby players were matched for body mass and randomly assigned to either a CWI group or control (CON) group. Following the simulated rugby match the CWI group underwent 2 x 5 min immersions at a temperature of 10°C separated by 2.5 min seated at room temperature, whilst the CON group remained seated for 15 min...
September 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28899371/simultaneous-detection-of-%C3%AE-lactoalbumin-%C3%AE-lactoglobulin-and-lactoferrin-in-milk-by-visualized-microarray
#11
Zhoumin Li, Fang Wen, Zhonghui Li, Nan Zheng, Jindou Jiang, Danke Xu
BACKGROUND: α-Lactalbumin (a-LA), β-lactoglobulin (β-LG) and lactoferrin (LF) are of high nutritional value which have made ingredients of choice in the formulation of modern foods and beverages. There remains an urgent need to develop novel biosensing methods for quantification featuring reduced cost, improved sensitivity, selectivity and more rapid response, especially for simultaneous detection of multiple whey proteins. RESULTS: A novel visualized microarray method was developed for the determination of a-LA, β-LG and LF in milk samples without the need for complex or time-consuming pre-treatment steps...
September 12, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28895063/considerations-in-the-use-of-body-mass-change-to-estimate-change-in-hydration-status-during-a-161-kilometer-ultramarathon-running-competition
#12
Martin D Hoffman, Eric D B Goulet, Ronald J Maughan
Hydration guidelines found in the scientific and popular literature typically advise that body mass losses beyond 2% should be avoided during exercise. In this work, we demonstrate that these guidelines are not applicable to prolonged exercise of several hours where body mass loss does not reflect an equivalent loss of body water due to the effects of body mass change from substrate use, release of water bound with muscle and liver glycogen, and production of water during substrate metabolism. These effects on the body mass loss required to maintain body water balance are shown for a 161-km mountain ultramarathon running competition participant utilizing published data for the total energy cost, exogenous energy consumption and percentage from each fuel source, average participant body mass, and the extent of soft tissue fluid accumulation during an ultramarathon...
September 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28893776/mycobacterium-tuberculosis-subculture-results-in-loss-of-potentially-clinically-relevant-heteroresistance
#13
John Z Metcalfe, Elizabeth Streicher, Grant Theron, Rebecca E Colman, Renee Penaloza, Christopher Allender, Darrin Lemmer, Robin M Warren, David M Engelthaler
Multidrug-resistant tuberculosis is a major public health dilemma. Heteroresistance, the co-existence of drug-resistant and drug-susceptible strains, or multiple drug-resistant strains with discrete haplotypes, may affect accurate diagnosis and institution of effective treatment. Subculture, or passage of cells onto fresh growth medium, is utilized to preserve M. tuberculosis cell lines and is universally employed in TB diagnostics. The impact of such passages, typically performed in the absence of drug, on drug-resistant subpopulations is hypothesized to vary according to the competitive costs of genotypic resistance-associated variants...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28892738/independent-operation-of-implicit-working-memory-under-cognitive-load
#14
Eunhee Ji, Kyung Min Lee, Min-Shik Kim
Implicit working memory (WM) has been known to operate non-consciously and unintentionally. The current study investigated whether implicit WM is a discrete mechanism from explicit WM in terms of cognitive resource. To induce cognitive resource competition, we used a conjunction search task (Experiment 1) and imposed spatial WM load (Experiment 2a and 2b). Each trial was composed of a set of five consecutive search displays. The location of the first four displays appeared as per pre-determined patterns, but the fifth display could follow the same pattern or not...
September 7, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28892240/phylogenetic-evidence-for-miocene-origin-of-mediterranean-lineages-species-diversity-reproductive-traits-and-geography
#15
Pablo Vargas, Mario Fernández-Mazuecos, Ruben Heleno
A review of 27 species-rich and species-poor plant clades (26 genera) of angiosperms of the Mediterranean floristic region was performed considering phylogenetic and biological data. The emergent pattern is that a majority of the Mediterranean plant clades split from their sister groups between the Miocene (23-5 Ma) and the Oligocene (40-23 Ma), far earlier than the historically proposed onset of the Mediterranean climate (c. 3.2 Ma). In addition, 12 clades of the species-poor group (14 clades) have stem ages inferred for each clade in the Miocene or older, and six clades within the species-rich group (13 clades) show divergence of each stem clade within the Oligocene and/or Miocene...
September 11, 2017: Plant Biology
https://www.readbyqxmd.com/read/28889807/no-nutritional-benefits-of-egg-cannibalism-for-coleomegilla-maculata-coleoptera-coccinellidae-on-a-high-quality-diet
#16
A H Abdelwahab, J P Michaud, M H Bayoumy, S S Awadalla, M El-Gendy
Egg cannibalism serves various functions in the Coccinellidae. Here we examined the fitness consequences of egg cannibalism by neonates, fourth instar larvae, and prereproductive adults of Coleomegilla maculata DeGeer, with beetles fed a diet of Ephestia kuehniella Zeller eggs. Cannibalism of two eggs by neonates had no effect on development, and cannibalism of five eggs by fourth instars did not benefit any aspect of reproduction, but delayed pupation slightly. Cannibalism of eggs by pre-reproductive adults had no effect on reproductive success in any combination of reciprocal crosses of cannibals and non-cannibals...
September 11, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28886935/examination-of-nondesignated-preliminary-surgery-residents-recruited-since-the-inception-of-supplementary-offer-and-acceptance-program-lessons-learned-from-a-large-academic-program
#17
Maria Albuja-Cruz, Claire Travis, Michael Benge, Barbara Caufield, Mark Nehler
PURPOSE: The majority of surgery programs roster non-designated preliminary (NDP) residents. We and others have reported on the success of NDP resident mentoring with regard to categorical position placement. Lacking is a focus on the candidates themselves and differences based on initial career of choice. METHODS: NDP residents' files since the institution of SOAP were reviewed for demographics, initial career choice, financial burden, region of medical school of origin, application and interview history, and pre-screen interview candidate score (high score of 22 - data includes USMLE scores, major clerkship grades, and AOA) used for categorical recruitment...
September 5, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28884847/how-does-the-exosite-of-rhomboid-protease-affect-substrate-processing-and-inhibition
#18
Michael Shokhen, Amnon Albeck
Rhomboid proteases constitute a family of intramembrane serine proteases ubiquitous in all forms of life. They differ in many aspects from their soluble counterparts. We applied molecular dynamics (MD) computational approach to address several challenging issues regarding their catalytic mechanism: How does the exosite of GlpG rhomboid protease control the kinetics efficiency of substrate hydrolysis? What is the mechanism of inhibition by the non-competitive peptidyl aldehyde inhibitors bound to the GlpG rhomboid active site (AS)? What is the underlying mechanism that explains the hypothesis that GlpG rhomboid protease is not adopted for the hydrolysis of short peptides that do not contain a transmembrane domain (TMD)? Two fundamental features of rhomboid catalysis, the enzyme recognition and discrimination of substrates by TMD interactions in the exosite, and the concerted mechanism of non-covalent pre-catalytic complex to covalent tetrahedral complex (TC) conversion, provide answers to these mechanistic questions...
September 8, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28882889/the-rho-adp-ribosylating-c3-exoenzyme-binds-cells-via-an-arg-gly-asp-motif
#19
Astrid Rohrbeck, Markus Höltje, Andrej Adolf, Elisabeth Oms, Sandra Hagemann, Gudrun Ahnert-Hilger, Ingo Just
The Rho ADP-ribosylating C3 exoenzyme (C3bot) is a bacterial protein toxin devoid of a cell-binding or -translocation domain. Nevertheless, C3 can efficiently enter intact cells, including neurons, but the mechanism of C3 binding and uptake is not yet understood. Previously, we identified the intermediate filament vimentin as an extracellular membranous interaction partner of C3. However, uptake of C3 into cells still occurs (although reduced) in the absence of vimentin, indicating involvement of an additional host cell receptor...
September 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28878457/effects-of-chronic-ankle-instability-and-induced-mediolateral-muscular-fatigue-of-the-ankle-on-competitive-taekwondo-athletes
#20
Myeounggon Lee, Changhong Youm, Minji Son, Jinhee Kim, Youkyung Kim
[Purpose] The purpose of this study was to investigate the effects of chronic ankle instability and induced mediolateral muscular fatigue of the ankle on competitive Taekwondo athletes during single-leg drop landing. [Subjects and Methods] Fourteen competitive taekwondo athletes with chronic ankle instability and 14 healthy adults participated, and they performed three single-leg drop landings from a 40-cm height before and after induced fatigue. Ankle angular position, peak vertical ground reaction force, loading rate, eccentric work, and contribution were calculated and analyzed...
August 2017: Journal of Physical Therapy Science
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