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https://www.readbyqxmd.com/read/28101259/the-science-teaching-fellows-program-a-model-for-online-faculty-development-of-early-career-scientists-interested-in-teaching
#1
Loretta Brancaccio-Taras, Kelly A Gull, Claudia Ratti
The American Society for Microbiology (ASM) has a history of providing a wide range of faculty development opportunities. Recently, ASM developed the Science Teaching Fellows Program (STF) for early career biologists and postdoctoral students to explore student-centered teaching and develop the skills needed to succeed in positions that have a significant teaching component. Participants were selected to STF through a competitive application process. The STF program consisted of a series of six webinars. In preparation for each webinar, participants completed a pre-webinar assignment...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28098849/no-evidence-for-mhc-class-ii-based-non-random-mating-at-the-gametic-haplotype-in-atlantic-salmon
#2
M Promerová, G Alavioon, S Tusso, R Burri, S Immler
Genes of the major histocompatibility complex (MHC) are a likely target of mate choice because of their role in inbreeding avoidance and potential benefits for offspring immunocompetence. Evidence for female choice for complementary MHC alleles among competing males exists both for the pre- and the postmating stages. However, it remains unclear whether the latter may involve non-random fusion of gametes depending on gametic haplotypes resulting in transmission ratio distortion or non-random sequence divergence among fused gametes...
January 18, 2017: Heredity
https://www.readbyqxmd.com/read/28095061/methods-of-monitoring-training-load-and-their-relationships-to-changes-in-fitness-and-performance-in-competitive-road-cyclists
#3
Dajo Sanders, Grant Abt, Matthijs K Hesselink, Tony Myers, Ibrahim Akubat
PURPOSE: The aim of this study was to assess the dose-response relationships between different training load methods and aerobic fitness and performance in competitive road cyclists. METHOD: Training data from 15 well-trained competitive cyclists were collected during a 10-week (December - March) pre-season training period. Before and after the training period, participants underwent a laboratory incremental exercise test with gas exchange and lactate measures and a performance assessment using an 8-min time trial (8MT)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28088686/immune-history-and-influenza-virus-susceptibility
#4
REVIEW
Sarah Cobey, Scott E Hensley
Antibody responses to influenza viruses are critical for protection, but the ways in which repeated viral exposures shape antibody evolution and effectiveness over time remain controversial. Early observations demonstrated that viral exposure history has a profound effect on the specificity and magnitude of antibody responses to a new viral strain, a phenomenon called 'original antigenic sin.' Although 'sin' might suppress some aspects of the immune response, so far there is little indication that hosts with pre-existing immunity are more susceptible to viral infections compared to naïve hosts...
January 12, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28088107/gaas-laser-therapy-reestablishes-the-morphology-of-the-nmj-and-nachrs-after-injury-due-to-bupivacaine
#5
Cristiane Neves Alessi Pissulin, Paula Aiello Tomé de Souza Castro, Flávio Codina, Carina Guidi Pinto, Ivan Jose Vechetti-Junior, Selma Maria Michelin Matheus
BACKGROUND: Local anesthetics are used to relieve pre- and postoperative pain, acting on both sodium channels and nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction (NMJ). Bupivacaine acts as a non-competitive antagonist and has limitations, such as myotoxicity, neurotoxicity, and inflammation. Low-level laser therapy (LLLT) has anti-inflammatory, regenerative, and analgesic effects. The aim of the present study was to evaluate the effects of a gallium arsenide laser (GaAs) on the morphology of the NMJ and nAChRs after application of bupivacaine in the sternomastoid muscle...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28080204/identification-of-hur-target-circular-rnas-uncovers-suppression-of-pabpn1-translation-by-circpabpn1
#6
Kotb Abdelmohsen, Amaresh C Panda, Rachel Munk, Ioannis Grammatikakis, Dawood B Dudekula, Supriyo De, Jiyoung Kim, Ji Heon Noh, Kyoung Mi Kim, Jennifer L Martindale, Myriam Gorospe
HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular RNAs (circRNAs) and impacts on their function is unknown. Here, we have identified en masse circRNAs binding HuR in human cervical carcinoma HeLa cells. One of the most prominent HuR target circRNAs was hsa_circ_0031288, renamed CircPABPN1 as it arises from the PABPN1 pre-mRNA. Further analyses revealed that HuR did not influence CircPABPN1 abundance; interestingly, however, high levels of CircPABPN1 suppressed HuR binding to PABPN1 mRNA...
January 12, 2017: RNA Biology
https://www.readbyqxmd.com/read/28073062/effects-of-payment-reform-in-more-versus-less-competitive-markets
#7
Neeraj Sood, Abby Alpert, Kayleigh Barnes, Peter Huckfeldt, José J Escarce
Policymakers are increasingly interested in reducing healthcare costs and inefficiencies through innovative payment strategies. These strategies may have heterogeneous impacts across geographic areas, potentially reducing or exacerbating geographic variation in healthcare spending. In this paper, we exploit a major payment reform for home health care to examine whether reductions in reimbursement lead to differential changes in treatment intensity and provider costs depending on the level of competition in a market...
December 30, 2016: Journal of Health Economics
https://www.readbyqxmd.com/read/28063048/monitoring-and-modulation-of-inducible-foxp3-regulatory-t-cell-differentiation-in-the-lymph-nodes-draining-the-small-intestine-and-colon
#8
S Veenbergen, L A van Berkel, M F du Pré, A E Kozijn, Janneke N Samsom
The mucosa-draining lymphoid tissue favors differentiation of inducible Foxp3(+) regulatory T cells. Adoptive transfer of T-cell receptor (TCR) transgenic (Tg) T cells is a powerful tool to study antigen-specific regulatory T-cell differentiation in lymphoid tissues in vivo. The kinetics and nature of the T-cell response largely depend on the route of antigen administration and degree of clonal competition. Here, we describe that adoptive transfer of CD4(+) DO11.10 TCR Tg T cells can be used for monitoring Foxp3(+) regulatory T-cell differentiation in the gut-draining lymph nodes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28062529/a-mixed-reality-simulator-concept-for-future-medical-emergency-response-team-training
#9
Robert J Stone, R Guest, P Mahoney, D Lamb, C Gibson
The UK Defence Medical Service's Pre-Hospital Emergency Care (PHEC) capability includes rapid-deployment Medical Emergency Response Teams (MERTs) comprising tri-service trauma consultants, paramedics and specialised nurses, all of whom are qualified to administer emergency care under extreme conditions to improve the survival prospects of combat casualties. The pre-deployment training of MERT personnel is designed to foster individual knowledge, skills and abilities in PHEC and in small team performance and cohesion in 'mission-specific' contexts...
January 6, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28060567/correlation-of-head-impacts-to-change-in-balance-error-scoring-system-scores-in-division-i-men-s-lacrosse-players
#10
Theresa L Miyashita, Eleni Diakogeorgiou, Kaitlyn Marrie
BACKGROUND: Investigation into the effect of cumulative subconcussive head impacts has yielded various results in the literature, with many supporting a link to neurological deficits. Little research has been conducted on men's lacrosse and associated balance deficits from head impacts. HYPOTHESES: (1) Athletes will commit more errors on the postseason Balance Error Scoring System (BESS) test. (2) There will be a positive correlation to change in BESS scores and head impact exposure data...
January 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28057857/a-central-role-of-cwc25-in-spliceosome-dynamics-during-catalytic-phase-of-pre-mrna-splicing
#11
Chi-Kang Tseng, Che-Sheng Chung, Hsin-Chou Chen, Soo-Chen Cheng
Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several proteins. Despite the energy requirement in the catalytic phase, incubation of the purified spliceosome under proper ionic conditions can elicit competitive reversible transesterification, debranching and spliced-exon-reopening reactions without necessity for ATP or other factors, suggesting that small changes in the conformational state of the spliceosome can lead to disparate chemical consequences for the substrate...
January 5, 2017: RNA
https://www.readbyqxmd.com/read/28052510/plant-diversity-enhances-moth-diversity-in-an-intensive-forest-management-experiment
#12
Heather T Root, Jake Verschuyl, Thomas Stokely, Paul Hammond, Melissa A Scherr, Matthew G Betts
Intensive forest management (IFM) promises to help satisfy increasing global demand for wood but may come at the cost of local reductions to forest biodiversity. IFM often reduces early seral plant diversity as a result of efforts to eliminate plant competition with crop trees. If diversity is a function of bottom-up drivers, theory predicts that specialists at lower trophic levels (e.g., insect herbivores) should be particularly sensitive to reductions in plant diversity. We conducted a stand-level experiment to test bottom-up controls on moth community structure, as mediated by degrees of forest management intensity...
January 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28051102/rna-synthesis-is-associated-with-multiple-tbp-chromatin-binding-events
#13
Hussain A Zaidi, David T Auble, Stefan Bekiranov
Competition ChIP is an experimental method that allows transcription factor (TF) chromatin turnover dynamics to be measured across a genome. We develop and apply a physical model of TF-chromatin competitive binding using chemical reaction rate theory and are able to derive the physical half-life or residence time for TATA-binding protein (TBP) across the yeast genome from competition ChIP data. Using our physical modeling approach where we explicitly include the induction profile of the competitor in the model, we are able to estimate yeast TBP-chromatin residence times as short as 1...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049295/-64-cu-labeled-trastuzumab-fab-peg24-egf-radioimmunoconjugates-bispecific-for-her2-and-egfr-pharmacokinetics-biodistribution-and-tumor-imaging-by-pet-in-comparison-to-monospecific-agents
#14
Luke Yongkyu Kwon, Deborah A Scollard, Raymond M Reilly
Heterodimerization of EGFR with HER2 coexpressed in breast cancer (BC) promotes tumor growth, and increased EGFR expression is associated with trastuzumab resistance. Our aim was to construct (64)Cu-labeled bispecific radioimmunoconjugates (bsRIC) composed of trastuzumab Fab, which binds HER2 linked through a polyethylene glycol (PEG24) spacer to EGF, and to compare their pharmacokinetic, biodistribution, and tumor imaging characteristics by positron-emission tomography (PET). bsRICs were generated by linking maleimide modified trastuzumab Fab with thiolated EGF through a thioether bond...
January 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28034741/identification-of-novel-small-molecule-inhibitors-against-ns2b-ns3-serine-protease-from-zika-virus
#15
Hyun Lee, Jinhong Ren, Salvatore Nocadello, Amy J Rice, Isabel Ojeda, Samuel Light, George Minasov, Jason Vargas, Dhanapalan Nagarathnam, Wayne F Anderson, Michael E Johnson
Zika flavivirus infection during pregnancy appears to produce higher risk of microcephaly, and also causes multiple neurological problems such as Guillain-Barré syndrome. The Zika virus is now widespread in Central and South America, and is anticipated to become an increasing risk in the southern United States. With continuing global travel and the spread of the mosquito vector, the exposure is expected to accelerate, but there are no currently approved treatments against the Zika virus. The Zika NS2B/NS3 protease is an attractive drug target due to its essential role in viral replication...
December 26, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28031765/physical-performance-during-water-polo-matches-the-effect-of-the-players-competitive-level
#16
Petros G Botonis, Argyris G Toubekis, Theodoros I Platanou
The purpose of the study was to compare playing intensity and performance changes within a water-polo match in players of different competitive levels. High-level (n = 7) and lower-level (n = 7) players performed a progressively increasing speed test of 5 x 200 m swimming and speed corresponding to lactate concentration of 4.0, 5.0 and 10.0 mmol•l-1 was calculated. Repeated sprint ability (8 x 20 m) was tested at pre-, the middle and post-match and a 400 m swimming test was completed at pre and post in five water-polo matches...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28030458/interorganizational-collaboration-in-emergency-cardiovascular-care
#17
James R Langabeer, Tiffany Champagne-Langabeer, Jeffrey R Helton, Wendy Segrest, Bita Kash, Jami DelliFraine, Raymond Fowler
BACKGROUND: Interorganizational collaboration management theory contends that cooperation between distinct but related organizations can yield innovation and competitive advantage to the participating organization. Yet, it is unclear if a multi-institutional collaborative can improve quality outcomes across communities. METHODS: We developed a large regional collaborative network of 15 hospitals and 24 emergency medical service agencies surrounding Dallas, Texas, and collected patient-level data on treatment times for acute myocardial infarctions...
January 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28028569/functional-testing-and-return-to-sport-following-stabilization-surgery-for-recurrent-lateral-patellar-instability-in-competitive-athletes
#18
Aaron J Krych, Michael P O'Malley, Nick R Johnson, Rohith Mohan, Timothy E Hewett, Michael J Stuart, Diane L Dahm
PURPOSE: Medial patellofemoral ligament (MPFL) reconstruction and tibial tubercle osteotomy are commonly used to treat recurrent lateral patellar instability, yet there are limited available data on return to sport (RTS) following these procedures. The purpose of this study is to evaluate patient factors associated with excellent functional outcomes, including successful RTS, following surgical stabilization including MPFL reconstruction in competitive athletes with recurrent lateral patellar instability...
December 27, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28008129/nesting-behavior-of-hy-line-hens-in-modified-enriched-colony-cages
#19
Michelle E Hunniford, Caitlin Woolcott, Janice Siegford, Tina M Widowski
Hens are motivated to seek out an enclosed nest site, but it is unclear whether the single communal nest in enriched colony cages (EC) adequately supports nesting. One method to investigate this is to provide an "alternative nest site" and determine the effects on laying location, timing of oviposition, and pre-laying behavior. The objective of this experiment was to determine whether increasing the degree of enclosure in the scratch area would influence egg laying location, time of oviposition, and pre-laying behavior...
December 22, 2016: Poultry Science
https://www.readbyqxmd.com/read/28005953/pathophysiological-consequences-of-a-break-in-s1p1-dependent-homeostasis-of-vascular-permeability-revealed-by-s1p1-competitive-antagonism
#20
Marc Bigaud, Zuhal Dincer, Birgit Bollbuck, Janet Dawson, Nicolau Beckmann, Christian Beerli, Gina Fishli-Cavelti, Michaela Nahler, Daniela Angst, Philipp Janser, Heike Otto, Elisabeth Rosner, Rene Hersperger, Christian Bruns, Jean Quancard
RATIONAL: Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known to reduce vascular barrier integrity with still unclear pathophysiological consequences. This was explored in the present study using NIBR-0213, a potent and selective S1P1 competitive antagonist. RESULTS: NIBR-0213 was tolerated at the efficacious oral dose of 30 mg/kg BID in the rat adjuvant-induced arthritis (AiA) model, with no sign of labored breathing...
2016: PloS One
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