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https://www.readbyqxmd.com/read/28422546/competition-sleep-is-not-compromised-compared-to-habitual-in-elite-australian-footballers
#1
Benita J Lalor, Shona L Halson, Jacquie Tran, Justin G Kemp, Stuart J Cormack
PURPOSE: To assess the impact of match start time and days relative to match compared to the habitual sleep characteristics of elite Australian Football (AF) players. METHODS: 45 elite male AF players were assessed during the pre-season (habitual) and across four home matches during the season. Players wore an activity monitor the night before (-1), night of (0), one night after (+1), and two nights (+2) after each match and completed a self-reported rating of sleep quality...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28422530/physiological-changes-following-competition-in-male-and-female-physique-athletes-a-pilot-study
#2
Eric T Trexler, Katie R Hirsch, Bill I Campbell, Abbie E Smith-Ryan
The purpose of the current study was to evaluate changes in body composition, metabolic rate, and hormones during post-competition recovery. Data were collected from natural physique athletes (7 male/8 female) within one week before (T1) competition, within one week after (T2), and 4-6 weeks after (T3) competition. Measures included body composition (fat mass [FM] and lean mass [LM] from ultrasongraphy), resting metabolic rate (RMR; indirect calorimetry), and salivary leptin, testosterone, cortisol, ghrelin, and insulin...
April 19, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28421004/neurosensory-and-cognitive-modifications-in-europe-s-toughest-randoraid-competition-the-transpyr%C3%A3-n%C3%A3-a-extreme-study
#3
Alessandro Tonacci, Simona Mrakic-Sposta, Kristian Ujka, Francesco Sansone, Alice Ferrisi, Guido Giardini, Raffaele Conte, Lorenza Pratali
Introduction: Given the wide proliferation of ultra-long endurance races, it is important to understand the physiological response of the athletes to improve their safety. We evaluated the cognitive and neurosensory effects on ultra-endurance athletes during the Transpyrénéa (866 Km, 65,000 m positive slope), held on the French Pyrenees. Materials and Methods: 40 athletes were enrolled (age 43.8 ± 8.8 years; 36 males). Olfactory and cognitive tests were performed before the race (T0, n = 40), at 166 kms (T1, n = 28), at 418 kms (T2, n = 20), and after the race (T3, 866 kms, n = 13)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28414203/self-assembled-nanocomplex-between-polymerized-phenylboronic-acid-and-doxorubicin-for-efficient-tumor-targeted-chemotherapy
#4
Junseok Lee, Jinhwan Kim, Yeong Mi Lee, Dongsik Park, Sooseok Im, Eun Ho Song, Hansoo Park, Won Jong Kim
Since the discovery that nano-scaled particulates can easily be incorporated into tumors via the enhanced permeability and retention (EPR) effect, such nanostructures have been exploited as therapeutic small molecule delivery systems. However, the convoluted synthetic process of conventional nanostructures has impeded their feasibility and reproducibility in clinical applications. Herein, we report an easily prepared formulation of self-assembled nanostructures for systemic delivery of the anti-cancer drug doxorubicin (DOX)...
April 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28410420/comparison-of-cell-based-assays-for-the-identification-and-evaluation-of-competitive-cxcr4-inhibitors
#5
Anneleen Van Hout, Thomas D'huys, Merel Oeyen, Dominique Schols, Tom Van Loy
The chemokine receptor CXCR4 is activated by its unique chemokine ligand CXCL12 and regulates many physiological and developmental processes such as hematopoietic cell trafficking. CXCR4 is also one of the main co-receptors for human immunodeficiency virus (HIV) entry. Dysfunction of the CXCL12/CXCR4 axis contributes to several human pathologies, including cancer and inflammatory diseases. Consequently, inhibition of CXCR4 activation is recognized as an attractive target for therapeutic intervention. In this regard, numerous agents modifying CXCR4 activity have been evaluated in in vitro experimental studies and pre-clinical models...
2017: PloS One
https://www.readbyqxmd.com/read/28406451/an-on-site-ultra-sensitive-quantitative-sensing-method-for-the-determination-of-total-aflatoxin-in-peanut-and-rice-based-on-quantum-dot-nanobeads-strip
#6
Suiyan Ouyang, Zhaowei Zhang, Ting He, Peiwu Li, Qi Zhang, Xiaomei Chen, Du Wang, Hui Li, Xiaoqian Tang, Wen Zhang
An on-site, ultra-sensitive, and quantitative sensing method was developed based on quantum dot nanobeads (QDNBs) and a test strip for the determination of total aflatoxins (AFTs) in rice and peanuts. The monoclonal antibody against AFT (mAbAFT) was homemade and labeled with QDNB. After the pre-coating of the AFT antigen on the test line (T line), the competitive immunoreactions were conducted between AFT and AFT antigen on the T line with QDNBs-mAbAFT. Under optimal conditions, this approach allowed a rapid response towards AFT with a considerable sensitivity of 1...
April 13, 2017: Toxins
https://www.readbyqxmd.com/read/28405282/ecological-application-of-biotic-resistance-to-control-the-invasion-of-an-invasive-plant-ageratina-altissima
#7
Chaeho Byun, Eun Ju Lee
Biotic resistance is the ability of species in a community to limit the invasion of other species. However, biotic resistance is not widely used to control invasive plants. Experimental, functional, and modeling approaches were combined to investigate the processes of invasion by Ageratina altissima (white snakeroot), a model invasive species in South Korea. We hypothesized that (1) functional group identity would be a good predictor of biotic resistance to A. altissima, whereas a species identity effect would be redundant within a functional group, and (2) mixtures of species would be more resistant to invasion than monocultures...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28403685/salivary-cortisol-responses-and-session-ratings-of-perceived-exertion-to-a-rugby-match-and-fatigue-test
#8
P C Caetano Júnior, M L Castilho, L Raniero
This study compared the effect of an official rugby match and a fatigue test on the salivary cortisol response of 13 rugby players. We also examined the relationship between this cortisol response and session ratings of perceived exertion (session-RPE). We collected saliva before and after the match and fatigue test and assessed physical effort intensity via session-RPE using a CR-10 scale. We measured cortisol concentration by enzyme-linked immunosorbent assays. Results were greater session-RPE and cortisol concentrations for the rugby match, compared with the fatigue test...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28398580/how-did-market-competition-affect-outpatient-utilization-under-the-diagnosis-related-group-based-payment-system
#9
Seung Ju Kim, Eun-Cheol Park, Sun Jung Kim, Kyu-Tae Han, Sung-In Jang
Objective: Although competition is known to affect quality of care, less is known about the effects of competition on outpatient health service utilization under the diagnosis-related group payment system. This study aimed to evaluate these effects and assess differences before and after hospitalization in South Korea. Design: Population-based retrospective observational study. Setting: We used two data set including outpatient data and hospitalization data from National Health Claim data from 2011 to 2014...
April 7, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28394834/changes-in-creatine-kinase-and-hormones-over-the-course-of-an-american-football-season
#10
J D Stone, A Kreutzer, J D Mata, M G Nystrom, A R Jagim, M T Jones, J M Oliver
The purpose of this study was to examine changes in creatine kinase and hormones over the course of an entire season of American football. A secondary purpose was to determine differences between starters and non-starters. Fasting blood samples were obtained from nineteen National Collegiate Athletic Association Division I (n = 19; 20 ± 1 years) football athletes over the course of a season beginning prior to the start of summer off-season conditioning (T1), before (T2) and after pre-season (T3) football camp, with remaining samples taken throughout the competitive season (T4-T8)...
April 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28394412/population-density-and-structure-drive-differential-investment-in-pre-and-postmating-sexual-traits-in-frogs
#11
Stefan Lüpold, Long Jin, Wen Bo Liao
Sexual selection theory predicts a trade-off between premating (ornaments and armaments) and postmating (testes and ejaculates) sexual traits, assuming that growing and maintaining these traits is costly and that total reproductive investments are limited. The number of males in competition, the reproductive gains from investing in premating sexual traits, and the level of sperm competition are all predicted to influence how males allocate their finite resources to these traits. Yet, empirical examination of these predictions is currently scarce...
April 10, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28393012/the-effect-of-repetitive-subconcussive-collisions-on-brain-integrity-in-collegiate-football-players-over-a-single-football-season-a-multi-modal-neuroimaging-study
#12
Semyon M Slobounov, Alexa Walter, Hans C Breiter, David C Zhu, Xiaoxiao Bai, Tim Bream, Peter Seidenberg, Xianglun Mao, Brian Johnson, Thomas M Talavage
The cumulative effect of repetitive subconcussive collisions on the structural and functional integrity of the brain remains largely unknown. Athletes in collision sports, like football, experience a large number of impacts across a single season of play. The majority of these impacts, however, are generally overlooked, and their long-term consequences remain poorly understood. This study sought to examine the effects of repetitive collisions across a single competitive season in NCAA Football Bowl Subdivision athletes using advanced neuroimaging approaches...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28391721/validity-and-usefulness-of-the-line-drill-test-for-adolescent-basketball-players-a-bayesian-multilevel-analysis
#13
Humberto M Carvalho, Carlos E Gonçalves, Bernard Grosgeorge, Roberto R Paes
The study examined the validity of the Line Drill test (LD) in male adolescent basketball players (10-15 years). Sensitiveness of the LD to changes in performance across a training and competition season (4 months) was also considered. Age, maturation, body size and LD were measured (n = 57). Sensitiveness of the LD was examined pre- and post-competitive season in a sub-sample (n = 44). The time at each of the four shuttle sprints of the LD (i.e. four stages) was modelled with Bayesian multilevel models...
April 10, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28389630/identification-of-small-molecule-inhibitors-of-the-aurora-a-tpx2-complex
#14
Italia Anna Asteriti, Frederick Daidone, Gianni Colotti, Serena Rinaldo, Patrizia Lavia, Giulia Guarguaglini, Alessandro Paiardini
Aurora kinases are a family of cell division regulators that govern the correct assembly of a bipolar mitotic spindle and the fidelity of chromosome segregation. Their overexpression is associated with genomic instability and aneuploidy, and is frequently observed in cancer. Accordingly, competitive inhibitors targeting Aurora kinase activity at the ATP-binding site are being investigated for therapeutic purposes. Despite promising pre-clinical data, these molecules display moderate effects in clinical trials and incomplete selectivity, either against distinct family members, or other kinases...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387576/dietary-micro-periodization-in-elite-female-and-male-runners-and-race-walkers-during-a-block-of-high-intensity-pre-competition-training
#15
Ida Aliisa Heikura, Louise Mary Burke, Antti A Mero, Arja Leena Tuulia Uusitalo, Trent Stellingwerff
We investigated one week of dietary micro-periodization in elite female (n=23) and male (n=15) runners and race-walkers by examining the frequency of training sessions and recovery periods conducted with recommended carbohydrate (CHO) and protein availability. Food and training diaries were recorded in relation to HARD (intense or >90min sessions; KEY) versus RECOVERY days (other-than KEY sessions; EASY). The targets for amount and timing of CHO and protein around KEY sessions were based on current nutrition recommendations...
April 7, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28387540/n-3-fatty-acid-supplementation-during-4-weeks-of-training-leads-to-improved-anaerobic-endurance-capacity-but-not-maximal-strength-speed-or-power-in-soccer-players
#16
Leyre Gravina, Frankie F Brown, Lee Alexander, James Dick, Gordon Bell, Oliver C Witard, Stuart D R Galloway
Omega-3 fatty acid (n-3 FA) supplementation could promote adaptation to soccer-specific training. We examined the impact of a 4 wk period of n-3 FA supplementation during training on adaptations in 1RM knee extensor strength, 20m sprint speed, vertical jump power, and anaerobic endurance capacity (Yo-Yo test) in competitive soccer players. Twenty six soccer players were randomly assigned to one of two groups: n-3 FA supplementation (n-3 FA; n=13) or placebo (n=13). Both groups performed two experimental trial days...
April 7, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28386997/the-transformation-in-biomarker-detection-and-management-of-drug-induced-liver-injury
#17
REVIEW
Rachel J Church, Paul B Watkins
Drug-induced liver injury (DILI) is a major concern for patients, care givers and the pharmaceutical industry. Interpretation of the serum biomarkers routinely used to detect and monitor DILI, which have not changed in almost 50 years, can be improved with recently proposed models employing quantitative systems pharmacology. In addition, several newer serum biomarkers are showing great promise. Studies in rodents indicate that the ratio of the caspase cleaved fragment of cytokeratin 18 to total K18 in serum (termed the "apoptotic index") estimates the relative proportions of apoptosis vs necrosis during drug-induced liver injury...
April 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28383252/prescreening-of-nicotine-hapten-linkers-in-vitro-to-select-hapten-conjugate-vaccine-candidates-for-pharmacokinetic-evaluation-in-vivo
#18
Viswanath Arutla, Joseph Leal, Xiaowei Liu, Sriram Sokalingam, Michael Raleigh, Adejimi Adaralegbe, Li Liu, Paul R Pentel, Sidney M Hecht, Yung Chang
Since the demonstration of nicotine vaccines as a possible therapeutic intervention for the effects of tobacco smoke, extensive effort has been made to enhance nicotine specific immunity. Linker modifications of nicotine haptens have been a focal point for improving the immunogenicity of nicotine, in which the evaluation of these modifications usually relies on in vivo animal models, such as mice, rats or nonhuman primates. Here, we present two in vitro screening strategies to estimate and predict the immunogenic potential of our newly designed nicotine haptens...
April 17, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28383169/growth-of-inn-nanowires-with-uniform-diameter-on-si-111-substrates-competition-between-migration-and-desorption-of-in-atoms
#19
Fangliang Gao, Lei Wen, Zhenzhu Xu, Jinglei Han, Yuefeng Yu, Shuguang Zhang, Guoqiang Li
The effects of the growth parameters on the uniformity and the aspect ratio of InN nanowires grown on Si(111) substrates have been studied systematically, and a modified quasi-equilibrium model is proposed. The growth temperature is of great importance for both the nucleation of the nanowires and the migration of In and N atoms, thus affecting the uniformity of the InN nanowires. In order to improve the uniformity of the InN nanowires, both traditional substrate nitridation and pre-In-droplet deposition have been implemented...
April 6, 2017: Small
https://www.readbyqxmd.com/read/28382702/post-surgery-circulating-free-tumor-dna-is-a-predictive-biomarker-for-relapse-of-lung-cancer
#20
Wenwei Hu, Yang Yang, Longzhen Zhang, Jianxin Yin, Jingwei Huang, Lei Huang, Hua Gu, Gening Jiang, Jianmin Fang
Cancer cells release DNA fragments into plasma as circulating free DNA (cfDNA). However, quantitative measurement of tumor-derived DNA in cfDNA remains challenge. The purpose of this study was to quantitatively assess tumor-derived DNA in lung cancer patients. By optimizing competitive allele-specific TaqMan PCR (CAST-PCR), we assessed the copy number of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) alleles in the pre/post surgery plasma of 168 lung cancer patients...
April 5, 2017: Cancer Medicine
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