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Sven Reuter, Andreas B Imhoff, Frank Martetschläger
BACKGROUND: The aim of this study was to systematically review the literature for the impact of rotator cuff tear (RCT) surgery on postoperative sporting activity in professional and recreational athletes. METHODS: To identify any published clinical study on return to sports data for athletes following rotator cuff surgery a systematic search in literature was conducted. Inclusion criteria were partial- and full-thickness rotator cuff tears and any open or arthroscopic RCT surgery in sports participating people...
October 20, 2016: Journal of Sports Medicine and Physical Fitness
Daniel Ben-Eliezer, Eldad Yechiam
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. We quantitatively reviewed the pre-clinical literature to examine if there is a cognitive-enhancing effect of H. perforatum in healthy rodents. Additionally, within these studies, we compared the effects observed in intact rodents versus those whose performance has been impaired, mostly through stress manipulations. The meta-analysis incorporated studies that examined the effect of H...
October 20, 2016: Scientific Reports
Wei-Lin Wang, David Shechter
Chromatin, primarily a complex of DNA and histone proteins, is the physiological form of the genome. Chromatin is generally repressive for transcription and other information transactions that occur on DNA. A wealth of post-translational modifications on canonical histones and histone variants encode regulatory information to recruit or repel effector proteins on chromatin, promoting and further repressing transcription and thereby form the basis of epigenetic information. During metazoan oogenesis, large quantities of histone proteins are synthesized and stored in preparation for the rapid early cell cycles of development and to elicit maternal control of chromatin assembly pathways...
2016: International Journal of Developmental Biology
Dimitrios Palaiogiannis, Evangelia Bekou, Kalliopi Pazaitou-Panayiotou, Victoria Samanidou, Andreas Tsakalof
The development and approbation of new, automated UHPLC-DAD method for the quantification of 25-hydroxyvitamin D3/D2 (25OH-D3/D2) metabolites in plasma/serum for the evaluation of patient's vitamin D status are presented. The method was developed on the Ultimate 3000 UHPLC dual gradient system supplied with the on-line SPE-concentration column coupled through six port switching valve to analytical column. This configuration and materials selected enable large volume sample injection (500μL) and on-line sample preconcentration, clean up and subsequent selective metabolites transfer onto the analytical column...
October 11, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Benoit Gendreau-Berthiaume, S Ellen Macdonald, J John Stadt
Understanding processes driving mortality in forests is important for comprehension of natural stand dynamics and for informing natural disturbance-based ecosystem management. There has been considerable study of mortality in forests during the self-thinning phase but we know much less about processes driving mortality in stands at later successional stages. We addressed this through study of five 1-ha spatially explicit permanent plots in mature (111-186 yr old in 2012) Pinus contorta stands in the Canadian Rocky Mountains using data from repeated measurements over a 45-yr period, dendrochronological information, and point pattern analysis...
July 2016: Ecological Applications: a Publication of the Ecological Society of America
Jie Li, Hongkun Jiang, Xiao Ouyang, Shihui Han, Jun Wang, Rui Xie, Wenting Zhu, Ning Ma, Hao Wei, Zhongyi Jiang
CaCO3 is one kind of important biological mineral, which widely exists in coral, shell and other organisms. Since similar to bone tissue elements and good biocompatibility, it was very suitable for candidates as bone drug carriers. In this paper, we used tetraethylenepentamine-graphene (rGO-TEPA) sheet matrices induction of CaCO3 mineralization and successfully constructed CaCO3/rGO-TEPA drug carriers with a hollow structure and rough surface. As potential drug carriers, doxorubicin (DOX) loading and release measurements were carried out...
October 18, 2016: ACS Applied Materials & Interfaces
Maryam Farahmandfar, Mehdi Kadivar, Sareh Rastipisheh
Behavioral abnormalities associated with opiate addiction include memory and learning deficits, which are the result of some alterations in the neuromodulatory systems. Recently, orexin has shown to influence drug addiction neural circuitry, specifically in mediating reward-related perception and memory. To explore the possible interaction of orexinergic and opioidergic system on modulation of learning and memory, we have investigated the effects of intra-dorsal hippocampal (intra-CA1) administration of orexin-1 receptor agonist and the competitive orexin-1 antagonist, SB-334867, on morphine-induced memory impairment by using step-down passive avoidance task in mice...
October 11, 2016: Neuropeptides
M V Nair, G M Miskelly
Clandestine laboratories pose a serious health risk to first responders, investigators, decontamination companies, and the public who may be inadvertently exposed to methamphetamine and other chemicals used in its manufacture. Therefore there is an urgent need for reliable methods to detect and measure methamphetamine at such sites. The most common method for determining methamphetamine contamination at former clandestine laboratory sites is selected surface wipe sampling, followed by analysis with gas chromatography-mass spectrometry (GC-MS)...
October 3, 2016: Forensic Science International
Derek D Satre, Andrea Altschuler, Sujaya Parthasarathy, Michael J Silverberg, Paul Volberding, Cynthia I Campbell
OBJECTIVES: This study examined implementation of the Affordable Care Act (ACA) in relation to HIV-positive patient enrollment in an integrated health care system; as well as changes in new enrollee characteristics, benefit structure and health care utilization after key ACA provisions went into effect in 2014. METHODS: This mixed-methods study was set in Kaiser Permanente Northern California (KPNC). Qualitative interviews with 29 KPNC leaders explored planning for ACA implementation...
October 3, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Joseph A McQuillan, Deborah K Dulson, Paul B Laursen, Andrew E Kilding
PURPOSE: To determine the effect of dietary nitrate (NO3(-)) supplementation on physiology and performance in well-trained cyclists following six to eight-days of NO3(-) supplementation. METHODS: Eight competitive male cyclists (mean ± SD; age = 26 ± 8 y; body mass = 76.7 ± 6.9 kg; VO2peak = 63 ± 4 participated in a double-blind, placebo-controlled, crossover-design study in which participants ingested 70 ml beetroot juice containing ~4 mmol NO3(-) (NIT) or a NO3(-) depleted placebo (PLA), each for 8-days...
October 13, 2016: International Journal of Sports Physiology and Performance
Alejandro Rodríguez-Fernández, Javier Sánchez Sánchez, José A Rodríguez-Marroyo, David Casamichana, José G Villa
BACKGROUND: Numerous studies have analyzed during competitive season different conditioning programs to improve soccer players' repeat sprint ability (RSA). However, few studies have focused on analysing what happens with this ability after small-sided games (SSG)-based training. Thus, the aim of this study was to determine the changes in physical performance after 5-weeks of pre-season training composed of SSGs in amateur soccer players. METHODS: Twenty-four male soccer players performed RSA, a sit-and-reach and two vertical jump (squat and counter movement jump) tests before and after 5-weeks of pre- season training using fundamentally SSGs...
October 13, 2016: Journal of Sports Medicine and Physical Fitness
Mark W Bruner, Ian D Boardley, Veronica Allan, Zach Root, Sara Buckham, Chris Forrest, Jean Côté
Social identity - identity formed through membership in groups - may play an important role in regulating intrateam moral behaviour in youth sport (Bruner, M. W., Boardley, I., & Côté, J. (2014). Social identity and prosocial and antisocial behavior in youth sport. Psychology of Sport and Exercise, 15(1), 56-64. doi:10.1016/j.psychsport.2013.09.003). The aim of this study was to qualitatively examine this potential role through stimulated recall interviews with competitive youth-ice-hockey players. Twenty-three players (Mage = 13...
October 13, 2016: Journal of Sports Sciences
Hee Kyong Oh, Se Jin Jeon, Sunhee Lee, Hyung Eun Lee, Eunji Kim, Se Jin Park, Ha Neul Kim, Won Yong Jung, Jae Hoon Cheong, Dae Sik Jang, Jong Hoon Ryu
Swertisin, a plant-derived C-glucosylflavone, is known to have antidiabetic, anti-inflammatory and antioxidant effects. In the present study, we investigated in mice the effects of swertisin on glutamatergic dysfunction induced by dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate receptor antagonist. In the Acoustic Startle Response test, their MK-801-induced (given 0.2 mg/kg i.p.) pre-pulse inhibition deficit was significantly attenuated by the administration of swertisin (30 mg/kg p.o.). In the Novel Object Recognition Test, the recognition memory impairments that were induced by MK-801 (0...
October 11, 2016: Journal of Psychopharmacology
Ayman Grada, Vincent Falanga
The number of individuals with chronic cutaneous wounds has been increasing worldwide due to an aging population, diabetes, obesity, and cardiovascular disease. In the United States, almost seven million Americans have chronic skin ulcers. Many therapeutic approaches have been used. However, the treatment outcomes are not always ideal because of failure to achieve complete wound closure in around 60% of cases, scarring, and high rate of recurrence. Therefore, there is a need for more effective therapies. Stem cells offer promising possibilities...
October 6, 2016: Surgical Technology International
Mélanie Gagnon, Allison Vimont, André Darveau, Ismaïl Fliss, Julie Jean
Rotavirus is the leading cause of severe acute gastroenteritis among children worldwide. Despite effective vaccines, inexpensive alternatives such as probiotics are needed. The aim of this study was to assess the ability of probiotic candidate Bifidobacterium thermophilum RBL67 to inhibit rotavirus infection. Bacterial adhesion to intestinal cells and interference with viral attachment were evaluated in vitro. B. thermophilum RBL67 displayed adhesion indexes of 625 ± 84 and 1958 ± 318 on Caco-2 and HT-29 cells respectively and was comparable or superior to four other bifidobacteria, including B...
2016: PloS One
Bing-Mae Chen, Yu-Cheng Su, Chia-Jung Chang, Pierre-Alain Burnouf, Kuo-Hsiang Chuang, Chien-Hsiun Chen, Tian-Lu Cheng, Yuan-Tsong Chen, Jer-Yuarn Wu, Steve R Roffler
Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeutic efficacy. Although antibodies with specificity for PEG may compromise the safety and effectiveness of PEGylated medicines, the prevalence of pre-existing anti-PEG antibodies in healthy individuals is unclear. Chimeric human anti-PEG antibody standards were created to accurately measure anti-PEG IgM and IgG antibodies by direct ELISA with confirmation by a competition assay in the plasma of 1504 healthy Han Chinese donors residing in Taiwan...
October 11, 2016: Analytical Chemistry
Kayam Chak, Biswajoy Roy-Chaudhuri, Hak Kyun Kim, Kayla C Kemp, Brenda E Porter, Mark A Kay
MicroRNA-21 (miR-21) is consistently up-regulated in various neurological disorders, including epilepsy. Here, we show that the biogenesis of miR-21 is altered following pilocarpine status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats. We demonstrate that pre-miR-21 has an energetically favorable site overlapping with the miR-21 binding site and competes with mature miR-21 for binding in the 3'UTR of TGFBR2 mRNA, but not NT-3 mRNA in vitro. This binding competition influences miR-21-mediated repression in vitro and correlates with the increase in TGFBR2 and decrease in NT-3 following SE...
October 7, 2016: Experimental Neurology
Doj Raj Khanal, Meera Prajapati, Prazila Shrestha, Madhav Prasad Acharya, Narayan Paudyal, Richard Bowen, Upendra Man Singh, Bhoj Raj Joshi
Bluetongue (BT) is one of the most economically important transboundary animal diseases. In recent years, it has been considered a disease related to climate change. A study was undertaken in 2013 in Nepal to measure the prevalence of Bluetongue virus (BTV) infection among domestic ruminants inhabiting the 3 agro-climatic zones with altitudes ranging from 150 to 2,400 metres above sea level. Twelve clusters representing the 3 altitudes were selected. The presence of antibodies against BTV was demonstrated in serum samples of sheep, goats, cattle, buffaloes, yaks/chauries, and chyangra goats (Himalayan goat) of Nepal...
September 30, 2016: Veterinaria Italiana
Shawn N Geniole, Brian M Bird, Erika L Ruddick, Justin M Carré
A contribution to a special issue on Hormones and Human Competition. Since Archer's (2006) influential meta-analysis, there has been a major increase in the number of studies investigating the effect of competition outcome on testosterone reactivity patterns in humans. Despite this increased research output, there remains debate as to whether competition outcome modulates testosterone concentrations. The present paper examines this question using a meta-analytic approach including papers published over the last 35years...
October 6, 2016: Hormones and Behavior
Amina Ledjeri, Idris Yahiaoui, Farida Aissani-Benissad
The removal of tetracycline (TC) by electro/Fe(3+)/peroxydisulfate process combined to the biological treatment is reported in this study. Effect of current density, peroxydisulfate (PDS) concentration, Fe(3+) ions concentration and initial tetracycline concentration were investigated. The results indicated that the removal efficiency of TC increased with increasing current density and decreases with tetracycline initial concentration. This effect is attributed to the competition of TC and electrogenerated intermediate compounds for the consumption of oxidizing SO4(-) radicals...
October 6, 2016: Journal of Environmental Management
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