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https://www.readbyqxmd.com/read/29349610/ligand-binding-dynamics-for-pre-dimerised-g-protein-coupled-receptor-homodimers-linear-models-and-analytical-solutions
#1
Carla White, Lloyd J Bridge
Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of ligand binding and signalling via receptor dimers is therefore required as an addition to classical receptor theory, which is largely built on assumptions of monomeric receptors. A key factor in developing theoretical models of dimer signalling is cooperativity across the dimer, whereby binding of a ligand to one protomer affects the binding of a ligand to the other protomer...
January 18, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29347856/systematic-review-of-injuries-in-mixed-martial-arts
#2
Roger E Thomas, Bennett C Thomas
OBJECTIVES: To assess injury rates in all mixed martial arts (MMA) studies. METHODS: Six online databases were searched until November 2017 including MEDLINE, EMBASE, CINAHL, Web of Science, PubMed, Google/Google Scholar and conference proceedings. All included studies were entered in Pub Med Single Citation Matcher and all citation chains followed. Abstracts and titles were assessed for relevance, data independently abstracted and risk of bias for all competition studies evaluated independently by two reviewers...
January 19, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29345173/effects-of-3-day-serial-sodium-bicarbonate-loading-on-performance-and-physiological-parameters-during-a-simulated-basketball-test-in-female-university-players
#3
Anne Delextrat, Sinead MacKessy, Luis Arceo-Rendon, Aaron Scanlan, Roger Ramsbottom, Julio Calleja-González
The aim of this study was to investigate the effect of 3-day serial sodium bicarbonate ingestion on repeated sprint and jump performance. Fifteen female university basketball players (23.3±3.4 years; 173.1±5.8 cm; 65.8±6.3 kg; 23.6±4.9% body fat) ingested 0.4 g·kg-1 of body mass of sodium bicarbonate or placebo for 3 days (split in 3 equal daily doses), before completing a simulated basketball exercise. Sprint and circuit times, jump heights, performance decrements and gastrointestinal (GI) side effects were recorded during the test and blood lactate concentration was measured pre- and post-test...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29340745/a-6-week-warm-up-injury-prevention-programme-results-in-minimal-biomechanical-changes-during-jump-landings-a-randomized-controlled-trial
#4
Jeffrey B Taylor, Kevin R Ford, Randy J Schmitz, Scott E Ross, Terry A Ackerman, Sandra J Shultz
PURPOSE: To examine the extent to which an ACL injury prevention programme modifies lower extremity biomechanics during single- and double-leg landing tasks in both the sagittal and frontal plane. It was hypothesized that the training programme would elicit improvements in lower extremity biomechanics, but that these improvements would be greater during a double-leg sagittal plane landing task than tasks performed on a single leg or in the frontal plane. METHODS: Ninety-seven competitive multi-directional sport athletes that competed at the middle- or high-school level were cluster randomized into intervention (n = 48, age = 15...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29336595/exploitation-of-microbial-antagonists-for-the-control-of-postharvest-diseases-of-fruits-a-review
#5
Ajinath Shridhar Dukare, Sangeeta Paul, V Eyarkai Nambi, Ram Kishore Gupta, Rajbir Singh, Kalyani Sharma, Rajesh Kumar Vishwakarma
Fungal diseases result in significant losses of fruits and vegetables during handling, transportation and storage. At present, post-production fungal spoilage is predominantly controlled by using synthetic fungicides. Under the global climate change scenario and with the need for sustainable agriculture, biological control methods of fungal diseases, using antagonistic microorganisms, are emerging as ecofriendly alternatives to the use of fungicides. The potential of microbial antagonists, isolated from a diversity of natural habitats, for postharvest disease suppression has been investigated...
January 16, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29332225/over-90%C3%A2-of-children-and-adolescents-return-to-sport-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-and-meta-analysis
#6
REVIEW
Jeffrey Kay, Muzammil Memon, Robert G Marx, Devin Peterson, Nicole Simunovic, Olufemi R Ayeni
PURPOSE: To evaluate the rate at which children and adolescent athletes return to sporting activities after anterior cruciate ligament (ACL) reconstruction. METHODS: Three databases, PubMed, MEDLINE, and EMBASE, were searched from database inception until September 9, 2017 by two reviewers independently and in duplicate. The inclusion criteria were English language studies that reported return to sport outcomes. Book chapters, conference papers, review articles, and technical reports were excluded...
January 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29331042/the-effects-of-social-context-and-food-abundance-on-chimpanzee-feeding-competition
#7
Rebecca Koomen, Esther Herrmann
Feeding competition is thought to play a role in primate social organization as well as cognitive evolution. For chimpanzees (Pan troglodytes), social and ecological factors can affect competition, yet how these factors interact to affect feeding behavior is not fully understood; they can be difficult to disentangle in wild settings. This experiment investigated the differential effects of food quantity, the presence of a co-feeding partner, and the contestability of a food patch on feeding rate. We presented tolerant pairs of chimpanzees from a semi-captive social group with an apparatus comprising a matrix of transparent tubes between two adjacent rooms, of which, either all (abundant condition) or only a small proportion (scarce condition) were baited with peanuts...
January 13, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29330780/safety-in-mixed-martial-arts-a-7-year-review-of-cancelled-mma-bouts-in-calgary-alberta-during-the-pre-bout-medical-examination-period
#8
Gwynn Curran-Sills
BACKGROUND: Presently, there is no literature that examines the reasons for the cancellation of amateur or professional mixed martial arts (MMA) bouts. The purpose of this study was to review the circumstances that lead to the cancellation of MMA bouts by Calgary ringside physicians during the pre-bout examination period and to identify any emerging patterns that may guide the regulatoin of this sport. METHODS: The case-series  was constructed from the Calgary Combative Sports Commission pre-bout examination records and the medical records submitted by each athlete from January 2010 to December 2016...
January 12, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29327828/the-acute-effects-of-stretching-with-vibration-on-dynamic-flexibility-in-young-female-gymnasts
#9
Aaron W Johnson, Caisa N Warcup, Matthew K Seeley, Dennis Eggett, Jeffery B Feland
BACKGROUND: While stretching with vibration has been shown to improve static flexibility; the effect of stretching with vibration on dynamic flexibility is not well known. The purpose of this study was to examine the effectiveness of stretching with vibration on acute dynamic flexibility and jump height in novice and advanced competitive female gymnasts during a split jump. METHODS: Female gymnast (n=27, age: 11.5 ± 1.7 years, Junior Olympic levels 5-10) participated in this cross-over study...
January 10, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29327649/the-effect-of-auditory-stimulus-training-on-swimming-start-reaction-time
#10
Christopher Papic, Peter Sinclair, Che Fornusek, Ross Sanders
Task-specific auditory training can improve sensorimotor processing times of the auditory reaction time (RT). The majority of competitive swimmers do not conduct habitual start training with the electronic horn used to commence a race. We examined the effect of four week dive training interventions on RT and block time (BT) of 10 male adolescent swimmers (age 14.0 ± 1.4 years): dive training with auditory components (speaker and electronic horn) (n = 5) and dive training without auditory components (n = 5)...
January 12, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29325759/snps-in-the-vicinity-of-p2x7r-rank-rankl-opg-and-wnt-signalling-pathways-and-their-association-with-bone-phenotypes-in-academy-footballers
#11
Ian Varley, David C Hughes, Julie P Greeves, William D Fraser, Craig Sale
CONTEXT: Genotype plays an important role in influencing bone phenotypes, such as bone mineral density, but the role of genotype in determining responses of bone to exercise has yet to be elucidated. OBJECTIVE: To determine whether 10 SNPs associated with genes in the vicinity of P2X7R, RANK/RANKL/OPG and Wnt Signalling Pathways are associated with bone phenotypes in elite academy footballers (Soccer players) and to determine whether these genotypes are associated with training induced changes in bone...
January 8, 2018: Bone
https://www.readbyqxmd.com/read/29324420/evaluation-of-hierarchical-watersheds
#12
Benjamin Perret, Jean Cousty, Silvio Jamil F Guimaraes, Deise S Maia
This paper aims to understand the practical features of hierarchies of morphological segmentations, namely the quasi-flat zones hierarchy and watershed hierarchies, and to evaluate their potential in the context of natural image analysis. We propose a novel evaluation framework for the hierarchies of partitions designed to capture various aspects of those representations: precision of their regions and contours, possibility to extract high quality horizontal cuts and optimal non-horizontal cuts for image segmentation, and the ease of finding a set of regions representing a semantic object...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29323902/maillard-conjugation-of-sodium-alginate-to-whey-protein-for-enhanced-resistance-to-surfactant-induced-competitive-displacement-from-air-water-interfaces
#13
Bingqing Cai, Anna Saito, Shinya Ikeda
Whey protein adsorbed to an interface forms a viscoelastic interfacial film but is displaced competitively from the interface by a small-molecule surfactant added afterward. The present study evaluated the impact of the covalent conjugation of high- or low-molecular-weight sodium alginate (HA or LA) to whey protein isolate (WPI) via the Maillard reaction on the ability of whey protein to resist surfactant-induced competitive displacement from the air-water interface. Surfactant added after the pre-adsorption of conjugate to the interface increased surface pressure...
January 11, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29322858/epidemiology-of-mental-health-conditions-in-incoming-division-i-collegiate-athletes
#14
Nikolas Sarac, Benjamin Sarac, Angela Pedroza, James Borchers
OBJECTIVES: The purpose of this study is to examine the epidemiology of mental health conditions in incoming American Division I collegiate athletes. METHODS: Pre-participation physical questionnaires from 1118 incoming student athletes at a Division I Institution were collected retrospectively from 2011-2017. Data collected included lifetime history of any mental health condition, musculoskeletal injuries, concussions, and post-concussion depression. History of any mental health condition was evaluated by gender and sport played...
January 11, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29318854/-effect-of-electroacupuncture-on-intracellular-calcium-ion-concentration-and-expression-of-calcium-calmodulin-dependent-protein-kinase-%C3%A2-in-lumbar-spinal-cord-in-rats-with-neuropathic-pain
#15
Xin-Tian Wu, Wei Liang, Li-Ping Yan, Ling-Ling Wang, Cheng Ma
OBJECTIVE: To observe the changes of intracellular calcium ([Ca2+]i) concentration and expression of calcium/calmodulin dependent protein kinaseⅡ (CaMKⅡ) in spinal dorsal horn neurons of spared nerve injury (SNI) rats, so as to explore its mechanisms underlying improvement of neuropathic pain. METHODS: One hundred and ten SD rats were randomly divided into 5 groups: sham control, model, EA, AP-5 and L-NAME groups. The sham group underwent only a simple separation of the sciatic nerve but without ligation and abscission...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29317065/nature-exposure-sufficiency-and-insufficiency-the-benefits-of-environmental-preservation
#16
John R Reddon, Salvatore B Durante
Increasing industrialization, urbanization, and a failure of many world leaders to appreciate the consequences of climate change are deleteriously impacting quality of life as well as diminishing the prospects for long term survival. Economic competitiveness and corporate profitability often pre-empt environmental concerns. The calving of an iceberg in Antarctica and the hurricane activity in the Caribbean during 2017 are unfortunate illustrations of the continuing escalation of environmental issues. We provide historical and current evidence for the importance of Nature Exposure (NE) and introduce the continuum Nature Exposure Sufficiency (NES) and Insufficiency (NEI)...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315577/bidirectional-variation-in-glutamate-efflux-in-the-medial-prefrontal-cortex-induced-by-selective-positive-and-negative-allosteric-mglur5-modulators
#17
Sarah N Isherwood, Trevor W Robbins, Jeffrey W Dalley, Anton Pekcec
Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive dysfunction and impaired inhibitory control in such neuropsychiatric disorders as schizophrenia, attention deficit hyperactivity disorder and drug addiction. Although NMDA receptors functionally interact with metabotropic glutamate receptor 5 (mGluR5), the consequence of this interaction for glutamate release in the prefrontal cortex (PFC) is unknown. We therefore investigated the effects of positive and negative allosteric mGluR5 modulation on changes in extracellular glutamate efflux in the medial PFC (mPFC) induced by systemic administration of the non-competitive NMDA receptor antagonist dizocilpine (or MK801) in rats...
January 6, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29313111/long-term-swimming-training-modifies-acute-immune-cell-response-to-a-high-intensity-session
#18
José P Morgado, Cristina P Monteiro, Catarina N Matias, Joana F Reis, Júlia Teles, Maria José Laires, Francisco Alves
PURPOSE: Long-term training influence on athletes' immune cell response to acute exercise has been poorly studied, despite the complexity of both chronic and acute adaptations induced by training. The purpose of the study is to study the influence of a 4-month swimming training cycle on the immune cell response to a high-intensity training session, during 24 h of recovery, considering sex, maturity, and age group. METHODS: Forty-three swimmers (16 females, 14.4 ± 1...
January 8, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29310513/sphingosine-1-phosphate-receptor-subtype-1-s1pr1-as-a-therapeutic-target-for-brain-trauma
#19
Salvatore Cuzzocrea, Timothy Doyle, Michela Campolo, Irene Paterniti, Emanuela Esposito, Susan Farr, Daniela Salvemini
Traumatic brain injury (TBI) provokes secondary pathological mechanisms, including ischemic and inflammatory processes. The new research in sphingosine 1-phosphate (S1P) receptor modulators has opened the door for an effective mechanism of reducing central nervous system (CNS) inflammatory lesion activity. Thus, the aim of this study was to characterize the immunomodulatory effect of the functional S1PR1 antagonist siponimod in Phase III clinical trials for autoimmune disorders and of the competitive S1PR1 antagonist TASP0277308 in preclinical development in an in vivo model of TBI in mice...
January 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29305509/transcriptional-responses-of-pseudomonas-aeruginosa-to-potable-water-and-freshwater
#20
Erika L English, Kristin C Schutz, Graham G Willsey, Matthew J Wargo
Many Pseudomonas aeruginosa infections are derived from residential, recreational, or surface water sources, thus, these environments represent an important pre-infection niche. To better understand P. aeruginosa biology in these environments, we quantified transcriptional changes by microarray after exposure to diluted LB, diluted R2B, potable tap water, and freshwater from a eutrophic pond. qRT-PCR confirmed conservation of these responses in other water sources, and competition experiments were used to test the importance of three implicated metabolic pathways...
January 5, 2018: Applied and Environmental Microbiology
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