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https://www.readbyqxmd.com/read/28813645/lat-is-essential-for-the-mast-cell-stabilising-effect-of-thga-in-ige-mediated-mast-cell-activation
#1
Ji Wei Tan, Daud Ahmad Israf, Nur Fariesha Md Hashim, Yoke Kqueen Cheah, Hanis Hazeera Harith, Khozirah Shaari, Chau Ling Tham
Mast cells play a central role in the pathogenesis of allergic reaction. Activation of mast cells by antigens is strictly dependent on the influx of extracellular calcium that involves a complex interaction between signalling molecules located within the cells. We have previously reported that tHGA, an active compound originally isolated from a local shrub known as Melicope ptelefolia, prevented IgE-mediated mast cell activation and passive systemic anaphylaxis by suppressing the release of interleukin-4 (IL-4) and tumour necrosis factor (TNF)-α from activated rat basophilic leukaemia (RBL)-2H3 cells...
August 13, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28811750/availability-of-a-sports-dietitian-may-lead-to-improved-performance-and-recovery-of-ncaa-division-i-baseball-athletes
#2
Michael V Hull, Jonathan Neddo, Andrew R Jagim, Jonathan M Oliver, Mike Greenwood, Margaret T Jones
BACKGROUND: The purpose was to survey dietary habits (DH) and nutrient timing (NT) practices of baseball student-athletes (mean ± SD; 20.7 ± 1.4 yr.) from three NCAA Division I institutions, and examine the effect of a sports dietitian (SD) in regard to nutrition practices. METHODS: Descriptive statistics and Pearson X(2) analyses were run. Responses on 10 DH and 5 NT items differed (p ≤ 0.10) between athletes who sought dietary planning from a SD (n = 36) versus those who consulted a strength and conditioning coach (SCC, n = 42)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28811191/can-psychological-well-being-scales-and-hormone-levels-be-used-to-predict-acute-performance-of-anaerobic-training-tasks-in-elite-female-volleyball-players
#3
Juan Mielgo-Ayuso, Michael C Zourdos, Vicente J Clemente-Suárez, Julio Calleja-González, Amber M Shipherd
The purpose of this study was to examine relationships between pre-training psychological well-being assessment scales (General Health Questionnaire-28-GHQ-28, Competitive State Anxiety Inventory-2-CSAI-2, Sport Competition Anxiety Test-SCAT, State-Trait Anxiety Inventory-S-STAI-S, Oviedo Sleep Questionnaire-OSQ and Psychological Characteristics Related to Sport Performance-PCSP), and pre-training stress hormone concentrations (cortisol-C, total testosterone-TT, free testosterone-FT, adrenocorticotropic hormone-ACTH and testosterone/cortisol-T/C ratios), on acute neuromuscular performance (ANP) in female volleyballers...
August 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28807886/mechanistic-insights-into-f420-dependent-glucose-6-phosphate-dehydrogenase-using-isotope-effects-and-substrate-inhibition-studies
#4
Mercy A Oyugi, Ghader Bashiri, Edward N Baker, Kayunta Johnson-Winters
F420-dependent glucose-6-phosphate dehydrogenase (FGD) is involved in the committed step of the pentose phosphate pathway within mycobacteria, where it catalyzes the reaction between glucose-6-phosphate (G6P) and the F420 cofactor to yield 6-phosphogluconolactone and the reduced cofactor, F420H2. Here, we aim to probe the FGD reaction mechanism using dead-end inhibition experiments, as well as solvent and substrate deuterium isotope effects studies. The dead-end inhibition studies performed using citrate as the inhibitor revealed competitive and uncompetitive inhibition patterns for G6P and F420 respectively, thus suggesting a mechanism of ordered addition of substrates in which the F420 cofactor must first bind to FGD before G6P binding...
August 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28800442/pre-trained-convolutional-neural-networks-as-feature-extractors-for-tuberculosis-detection
#5
U K Lopes, J F Valiati
It is estimated that in 2015, approximately 1.8 million people infected by tuberculosis died, most of them in developing countries. Many of those deaths could have been prevented if the disease had been detected at an earlier stage, but the most advanced diagnosis methods are still cost prohibitive for mass adoption. One of the most popular tuberculosis diagnosis methods is the analysis of frontal thoracic radiographs; however, the impact of this method is diminished by the need for individual analysis of each radiography by properly trained radiologists...
August 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28797900/elimination-and-ecotoxicity-evaluation-of-phthalic-acid-esters-from-textile-dyeing-wastewater
#6
Jieying Liang, Xun-An Ning, Minyi Kong, Daohua Liu, Guangwen Wang, Haili Cai, Jian Sun, Yaping Zhang, Xingwen Lu, Yong Yuan
Phthalic acid esters (PAEs), presented in fabrics, surfactants and detergents, were discharged into the ecosystem during textile-dyeing wastewater treatment and might have adverse effects on water ecosystems. In this study, comprehensive investigations of the content and component distributions of 12 PAEs across different units of four textile-dyeing wastewater plants were carried out in Guangdong Province, China. Ecotoxicity assessments were also conducted based on risk quotients (RQs). On average, 93.54% TOC and 80...
August 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28797054/large-scale-wheat-flour-folic-acid-fortification-program-increases-plasma-folate-levels-among-women-of-reproductive-age-in-urban-tanzania
#7
Ramadhani A Noor, Ajibola I Abioye, Nzovu Ulenga, Salum Msham, George Kaishozi, Nilupa S Gunaratna, Ramadhani Mwiru, Erin Smith, Christina Nyhus Dhillon, Donna Spiegelman, Wafaie Fawzi
There is widespread vitamin and mineral deficiency problem in Tanzania with known deficiencies of at least vitamin A, iron, folate and zinc, resulting in lasting negative consequences especially on maternal health, cognitive development and thus the nation's economic potential. Folate deficiency is associated with significant adverse health effects among women of reproductive age, including a higher risk of neural tube defects. Several countries, including Tanzania, have implemented mandatory fortification of wheat and maize flour but evidence on the effectiveness of these programs in developing countries remains limited...
2017: PloS One
https://www.readbyqxmd.com/read/28795636/athletic-identity-and-psychiatric-symptoms-following-retirement-from-varsity-sports
#8
Zarina A Giannone, Colleen J Haney, David Kealy, John S Ogrodniczuk
BACKGROUND: Despite evidence identifying adjustment difficulties among retiring athletes, research investigating factors that contribute to post-retirement complications is limited. Athletic identity may be an important determinant of adverse adaptation to sport retirement. AIMS: The purpose of this study was to address the influence of athletic identity on post-retirement depression and anxiety symptoms among varsity athletes. METHOD: An anonymous, online survey regarding athletic identity and psychiatric symptoms was completed by 72 self-identified varsity athletes during their final season of competition and 3 months after retiring from sport...
August 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28792501/a-3-dimensional-mathematical-model-of-microbial-proliferation-that-generates-the-characteristic-cumulative-relative-abundance-distributions-in-gut-microbiomes
#9
Lena Takayasu, Wataru Suda, Eiichiro Watanabe, Shinji Fukuda, Kageyasu Takanashi, Hiroshi Ohno, Misako Takayasu, Hideki Takayasu, Masahira Hattori
The gut microbiome is highly variable among individuals, largely due to differences in host lifestyle and physiology. However, little is known about the underlying processes or rules that shape the complex microbial community. In this paper, we show that the cumulative relative abundance distribution (CRAD) of microbial species can be approximated by a power law function, and found that the power exponent of CRADs generated from 16S rRNA gene and metagenomic data for normal gut microbiomes of humans and mice was similar consistently with ∼0...
2017: PloS One
https://www.readbyqxmd.com/read/28791164/do-pet-dogs-canis-familiaris-follow-ostensive-and-non-ostensive-human-gaze-to-distant-space-and-to-objects
#10
Charlotte Duranton, Friederike Range, Zsófia Virányi
Dogs are renowned for being skilful at using human-given communicative cues such as pointing. Results are contradictory, however, when it comes to dogs' following human gaze, probably due to methodological discrepancies. Here we investigated whether dogs follow human gaze to one of two food locations better than into distant space even after comparable pre-training. In Experiments 1 and 2, the gazing direction of dogs was recorded in a gaze-following into distant space and in an object-choice task where no choice was allowed, in order to allow a direct comparison between tasks, varying the ostensive nature of the gazes...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28789851/antibody-persistence-and-evidence-of-immune-memory-at-5years-following-administration-of-the-9-valent-hpv-vaccine
#11
Ana Guevara, Robinson Cabello, Linn Woelber, Edson Duarte Moreira, Elmar Joura, Olaf Reich, Christine Shields, Misoo C Ellison, Amita Joshi, Alain Luxembourg
BACKGROUND: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28789718/cardiovascular-pre-participation-screening-in-young-athletes-recommendations-of-the-association-of-european-paediatric-cardiology
#12
Peter Fritsch, Robert Dalla Pozza, Doris Ehringer-Schetitska, Eero Jokinen, Vesna Herceg, Erzsebet Hidvegi, Renate Oberhoffer, Andreas Petropoulos
Sudden death in young competitive athletes can be avoided by implementation of pre-participation screening programmes. A screening programme should be performed only by trained physicians and should include the athlete's personal and family history, physical examination results, and the readings from a 12-lead-electrocardiogram. The athlete should undergo this screening programme every second year to detect progressive diseases. In addition, the programme should include detailed instructions to the athletes to pause training during infections in order to prevent sudden death due to myocarditis...
August 9, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28777247/a-comparison-of-pre-season-and-in-season-practice-and-game-loads-in-ncaa-division-i-football-players
#13
Aaron D Wellman, Sam C Coad, Patrick J Flynn, Ty K Siam, Christopher P McLellan
The aim of the present study was to quantify the individual practice and game loads throughout an NCAA division I football season to determine if significant differences exist between the practice loads associated with pre-season training camp and those undertaken during the in-season period. Thirty-one NCAA division I football players were monitored using GPS and IA (MinimaxX S5; Catapult Innovations, Melbourne, Australia) during 22 pre-season practices, 36 in-season practices, and 12 competitions. The season was divided into four distinct phases for data analysis: pre-season week 1 (pre-season1), pre-season week 2 (pre-season2), pre-season week 3 (pre-season3), and 12 in-season weeks...
July 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28776295/effects-of-pre-oxidation-and-adsorption-on-haloacetonitrile-and-trichloronitromethane-formation-during-subsequent-chlorination
#14
Zhigang Liu, Wei Chen, Hu Yu, Hui Tao, Hang Xu, Jingjing Yu, Yanmei Gu, Zhen Wan
In this study, the effects of pre-oxidants permanganate (PM), persulfate (PS), hydrogen peroxide (PO), and ozone (OZ)) and/or adsorption on pseudoboemite-chitosan shell magnetic nanoparticles (ACMNs) on haloacetonitrile (HAN) and trichloronitromethane (TCNM) formation from aspartic acid (Asp; positive charge) and/or histidine (His; negative charge) were compared. Asp and His apparently do not interact in aqueous solution during chlorination. Asp and/or His can undergo partially oxidation by PM, but are recalcitrant to direct oxidation by PS and PO...
August 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28772090/nmda-receptors-in-the-dorsal-hippocampal-area-are-involved-in-tramadol-state-dependent-memory-of-passive-avoidance-learning-in-mice
#15
Majid Jafari-Sabet, Hamed Mofidi, Mohammad-Sadegh Attarian-Khosroshahi
The neurobiological mechanisms of tramadol abuse underlying the cognitive function are still imprecise. Considering these, the aim of the present study was to examine the possible effects of intra-CA1 injections of NMDA, an N-methyl-D-aspartate glutamate receptor (NMDAR) agonist and DL-AP5, a competitive NMDAR antagonist, on tramadol state-dependent memory. A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice. Post-training i.p. administration of an atypical MOR agonist, tramadol (2...
August 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28768877/immunodominance-of-adenovirus-derived-cd8-t-cell-epitopes-interferes-with-the-induction-of-transgene-specific-immunity-in-adenovirus-based-immunization
#16
Dominik Schöne, Camilla Patrizia Hrycak, Sonja Windmann, Dennis Lapuente, Ulf Dittmer, Matthias Tenbusch, Wibke Bayer
Adenovirus (Ad)-based immunization is a popular approach in vaccine development, and Ad-based vectors are renowned for their potential to induce strong CD8(+) T cell responses to the encoded transgene. Surprisingly, we found before in the mouse Friend retrovirus (FV) model that Ad-based immunization did not induce CD8(+) T cell responses to the FV Leader-Gag-derived immunodominant epitope GagL85-93 We show now that induction of GagL85-93-specific CD8(+) T cells was highly effective when Leader-Gag was delivered by plasmid DNA immunization, implying a role for Ad-derived epitopes in mediating unresponsiveness...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28754835/in-vivo-functional-selection-identifies-cardiotrophin-1-as-a-cardiac-engraftment-factor-for-mesenchymal-stromal-cells
#17
Francesca Bortolotti, Giulia Ruozi, Antonella Falcione, Sara Doimo, Matteo Dal Ferro, Pierluigi Lesizza, Lorena Zentilin, Lawrence Banks, Serena Zacchigna, Mauro Giacca
Background -Transplantation of cells into the infarcted heart has significant potential to improve myocardial recovery; however, low efficacy of cell engraftment still limits therapeutic benefit. Here we describe a method for the unbiased, in vivo selection of cytokines that improve mesenchymal stromal cell (MSC) engraftment into the heart in both normal conditions and after myocardial infarction. Methods -An arrayed library of 80 secreted factors, including most of the currently known interleukins and chemokines, were individually cloned into adeno-associated viral (AAV) vectors...
July 28, 2017: Circulation
https://www.readbyqxmd.com/read/28729707/status-stress-and-performance-in-track-and-field-athletes-during-the-european-games-in-baku-azerbaijan
#18
Benjamin Siart, Alfred Nimmerichter, Claudia Vidotto, Bernard Wallner
This study analyzes the relationship between salivary cortisol and testosterone levels and performance in track and field athletes. In addition, we analyzed the influence of status among athletes (measured based on previous athletic achievement) on hormone levels. Nineteen members of the Austrian track and field team (eleven males, eight females, 25.9 ± 3.9 years of age, 74.9 ± 20.1 kg, and 179.3 ± 10 cm) participated in this study. Data was collected during the European Games in Baku. Athletes delivered saliva samples at various time-points including morning samples and samples directly before and after the competition...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729018/sustained-reduction-in-vaccine-type-invasive-pneumococcal-disease-despite-waning-effects-of-a-catch-up-campaign-in-kilifi-kenya-a-mathematical-model-based-on-pre-vaccination-data
#19
John Ojal, Stefan Flasche, Laura L Hammitt, Donald Akech, Moses C Kiti, Tatu Kamau, Ifedayo Adetifa, Markku Nurhonen, J Anthony G Scott, Kari Auranen
BACKGROUND: In 2011, Kenya introduced the 10-valent pneumococcal conjugate vaccine together with a catch-up campaign for children aged <5years in Kilifi County. In a post-vaccination surveillance study based in Kilifi, there was a substantial decline in invasive pneumococcal disease (IPD). However, given the continued circulation of the vaccine serotypes it is possible that vaccine-serotype disease may re-emerge once the effects of the catch-up campaign wear off. METHODS: We developed a compartmental, age-structured dynamic model of pneumococcal carriage and invasive disease for three serotype groups: the 10-valent vaccine serotypes and two groups of non-vaccine serotypes based on their susceptibility to mutual competition...
July 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28714826/effects-of-peroneal-muscles-fatigue-on-dynamic-stability-following-lateral-hop-landing-time-to-stabilization-vs-dynamic-postural-stability-index
#20
Kazem Malmir, Gholam Reza Olyaei, Saeed Talebian, Ali Ashraf Jamshidi, Majid Ashraf Ganguie
CONTEXT: Dynamic stability is a necessary requirement in many sports competitions. Muscle fatigue, which can impair stability, may be occurred in many sports competitions in which lateral movements and landing repeated frequently. OBJECTIVE: To assess the effects of peroneal muscles fatigue on dynamic stability following lateral hop landing through measuring time to stabilization (TTS) and dynamic postural stability index (DPSI). DESIGN: Quasi-experimental...
July 17, 2017: Journal of Sport Rehabilitation
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