keyword
MENU ▼
Read by QxMD icon Read
search

Pre competition

keyword
https://www.readbyqxmd.com/read/28636974/sema3a-partially-reverses-vegf-effects-through-binding-to-neuropilin-1
#1
Bruna Palodetto, Adriana da Silva Santos Duarte, Matheus Rodrigues Lopes, Flavia Adolfo Corrocher, Fernanda Marconi Roversi, Fernanda Soares Niemann, Karla Priscila Vieira Ferro, Ana Leda Figueiredo Longhini, Paula Melo Campos, Patricia Favaro, Sara Teresinha Olalla Saad
Cross-talk between hematopoietic stem cells (HSCs) and bone marrow stromal cells (BMSCs) is essential for HSCs regulation and leukemogenesis. Studying bone marrow of myelodysplasia patients, a pre-leukemic condition, we found mRNA overexpression of vascular endothelial growth factor A (VEGFA) in CD34(+) HSCs and semaphorin 3A (SEMA3A) in BMSCs. To better understand the role of VEGFA and SEMA3A in leukemogenesis, we recruited 30 myelodysplastic syndrome (MDS) patients, 29 acute myeloid leukemia (6 secondary to MDS) patients and 12 controls...
June 3, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28634517/introduction-of-a-quality-improvement-curriculum-in-the-department-of-internal-medicine-lincoln-medical-center
#2
Usha Venugopal, Moiz Kasubhai, Vikram Paruchuri
Community hospitals with limited resources struggle to engage physicians in Quality improvement initiatives. We introduced Quality Improvement (QI) curriculum for residents in response to ACGME requirements and surveyed the residents understanding of QI and their involvement in QI projects before and after the introduction of the curriculum. The current article describes our experiences with the process, the challenges and possible solutions to have a successful resident led QI initiative in a community hospital...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28630584/time-loss-injuries-in-sub-elite-and-emerging-rugby-league-players
#3
Mark Booth, Rhonda Orr
This study aimed to 1) investigate the incidence and characteristics of injuries in emerging rugby league players; and 2) explore the differences in injury incidence and characteristics between the various sub-elite competitions. An NRL emerging player development squad (n = 34) was observed from the beginning of pre-season until the finish of competition. Time-loss injury was defined as any physical pain or impairment sustained that resulted in players missing a match. Injuries were categorised according to circumstance, incidence, characteristics, playing position and competition level...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28629813/recruitment-failure-of-scleractinian-corals-in-a-subtropical-marginal-environment-three-year-monitoring-in-a-hong-kong-marine-park
#4
Apple Pui Yi Chui, Put Ang
Coral recruitment was monitored for three years, using terracotta tiles, in two core coral areas in Tung Ping Chau Marine Park where coral coverage is one of the richest in Hong Kong. Results revealed an extremely low recruitment success of corals, with only 10 recruits recorded on 384 tile pairs, equivalent to 0.19 recruits m(-2)yr(-1) throughout the study period. Recruits of Platygyra acuta pre-seeded on tiles that were subsequently grown in situ experienced very high mortality following settlement, with average mortality of 80% within half a month and <0...
June 16, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28628396/differential-in-maximal-aerobic-capacity-by-sex-in-collegiate-endurance-athletes-consuming-a-marginally-low-carbohydrate-diet
#5
Marissa N Baranauskas, Brian Miller, Jordan T Olson, Michelle Boltz, Laura Richardson, Matthew Juravich, Ronald Otterstetter
PURPOSE: Although current sports nutrition recommendations advocate for a high carbohydrate (CHO) intake among endurance athletes, recent research has suggested that training with low CHO availability may augment adaptations to aerobic training. The purpose of this study was to observe the dietary habits of collegiate distance runners and to investigate the effects of habitual CHO intake on aerobic performance [VO2max(post)] during a competitive season. METHODS: During an 8-week trial period, 12 (N = 12) collegiate track athletes recorded their self-selected dietary intake via 24-hour recall...
June 19, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28625539/investigating-the-effects-of-maximal-anaerobic-fatigue-on-dynamic-postural-control-using-the-y-balance-test
#6
William Johnston, Kara Dolan, Niamh Reid, Garrett F Coughlan, Brian Caulfield
OBJECTIVES: The Y Balance Test is one of the most commonly used dynamic balance assessments, providing an insight into the integration of the sensorimotor subsystems. In recent times, there has been an increase in interest surrounding it's use in various clinical populations demonstrating alterations in motor function. Therefore, it is important to examine the effect physiological influences such as fatigue play in dynamic postural control, and establish a timeframe for its recovery. DESIGN: Descriptive laboratory study...
June 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28624695/first-in-human-phase-i-study-of-oral-s49076-a-unique-met-axl-fgfr-inhibitor-in-advanced-solid-tumours
#7
Jordi Rodon, Sophie Postel-Vinay, Antoine Hollebecque, Paolo Nuciforo, Analia Azaro, Valérie Cattan, Lucie Marfai, Isabelle Sudey, Karl Brendel, Audrey Delmas, Stéphanie Malasse, Jean-Charles Soria
BACKGROUND AND OBJECTIVES: S49076 is a novel ATP-competitive tyrosine kinase inhibitor of MET, AXL and FGFR with a unique selectivity profile. A phase I open-label study was undertaken to establish the tolerability profile and determine the recommended dose (RD) and administration schedule. MATERIALS AND METHODS: Patients with advanced solid tumours received S49076 orally once-daily (qd) or twice-daily (bid) in continuous 21-day cycles at escalating doses guided by a 3 + 3 design and followed by an expansion phase at the RD...
June 15, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28621884/young-athletes-with-ventricular-premature-beats-continuing-or-not-intense-training-and-competition
#8
Attilio Parisi, Eliana Tranchita, Carlo Minganti, Fabio Sperandii, Emanuele Guerra, Leonardo Calò, Paolo Borrione, Fabio Pigozzi
INTRODUCTION: Isolated ventricular premature beats (VPBs) are commonly found during pre-participation screening in athletes. Currently the debate about the role of detraining in reducing the number of VPBs is still open. This study evaluated the arrhythmic risk in a population of young competitive athletes who showed VPBs during eligibility evaluation and that did not undergo detraining but continued practicing competitive sports. METHODS: 3746 consecutive subjects underwent pre-participation screening...
June 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28614628/temperature-dependence-of-the-rates-of-reaction-of-trifluoracetic-acid-with-criegee-intermediates
#9
Rabi Chhantyal-Pun, Max McGillen, Joseph Beames, Anwar Khan, Carl Percival, Dudley Shallcross, Andrew Orr-Ewing
The rate coefficients for gas-phase reactions of trifluoroacetic acid (TFA) with two Criegee intermediates, formaldehyde oxide and acetone oxide, decrease with increasing temperature in the range 240 - 340 K. The rate coefficients k(CH2OO + TFA) = (3.4 ± 0.3) × 10-10 cm3 s-1 and k((CH3)2COO + TFA) = (6.1 ± 0.2) × 10-10 cm3 s-1 at 294 K exceed estimates for collision-limited values, suggesting rate enhancement by capture mechanisms because of the large permanent dipole moments of the two reactants. The observed temperature dependence is attributed to competitive stabilization of a pre-reactive complex...
June 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28613960/the-effect-of-air-pollution-on-diurnal-variation-of-performance-in-anaerobic-tests-cardiovascular-and-hematological-parameters-and-blood-gases-on-soccer-players-following-the-yo-yo-intermittent-recovery-test-level-1
#10
Nesrin Boussetta, Salma Abedelmalek, Khouloud Aloui, Nizar Souissi
This study aimed to investigate the effect of air pollution on diurnal variation of performance in anaerobic tests, cardiovascular and hematological parameters, and blood gases on soccer players following the Yo-Yo Intermittent Recovery Test Level-1 (YYIRT1). In a randomized order, 11 healthy soccer players (mean age: 21.8 [range: 20-24] years; height: 178.00 [range: 1.64-1.83] cm; body mass index [BMI]: 23.57 [range: 20.45-28.03] kg.m(-2)) performed a YYIRT1 at two different times of day (TOD) (08:00 h and 18:00 h) in two areas (i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28600967/mechanisms-of-cell-competition-emerging-from-drosophila-studies
#11
Nicholas E Baker
Cell competition was described in Drosophila as the loss from mosaic tissues of otherwise viable cells heterozygous for Ribosomal protein mutations ('Minutes'). Cell competition has now been described to occur between multiple other genotypes, such as cells differing in myc expression levels, or mutated for neoplastic tumor suppressors. Recent studies implicate innate immunity components, and possibly mechanical stress, compression and cell intercalation as a consequence of differential growth rates in competitive cell death...
June 7, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28600887/therapeutic-effects-of-fgf23-c-tail-fc-in-a-murine-pre-clinical-model-of-x-linked-hypophosphatemia-via-the-selective-modulation-of-phosphate-reabsorption
#12
Kristen Johnson, Kymberly Levine, Joseph Sergi, Jean Chamoun, Rachel Roach, Jackie Vekich, Mike Favis, Mark Horn, Xianjun Cao, Brian Miller, William Snyder, Dikran Aivazian, William Reagan, Edwin Berryman, Jennifer Colangelo, Victoria Markiewicz, Cedo Bagi, Thomas P Brown, Anthony Coyle, Moosa Mohammadi, Jeanne Magram
Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype. FGF23 inhibits phosphate reabsorption and suppresses 1α,25-dihydroxyvitamin D (1,25D) biosynthesis, analytes that differentially contribute to bone integrity and deleterious soft tissue mineralization. As inhibition of ligand broadly modulates downstream targets, balancing efficacy and unwanted toxicity is difficult when targeting the FGF23 pathway...
June 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28599797/variability-in-interpretation-of-the-electrocardiogram-in-athletes-another-limitation-in-pre-competitive-screening
#13
Hélder Dores, José Ferreira Santos, Paulo Dinis, Francisco Moscoso Costa, Lígia Mendes, José Monge, António Freitas, Pedro de Araújo Gonçalves, Nuno Cardim, Miguel Mendes
INTRODUCTION: Assessment of the electrocardiogram (ECG) in athletes remains controversial, with lack of standardization and difficulty in applying specific criteria in its interpretation. The purpose of this study was to assess variability in the interpretation of the ECG in athletes. METHODS: Twenty ECGs of competitive athletes were assessed by cardiologists and cardiology residents, 11 of them normal or with isolated physiological changes and nine pathological...
June 6, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28592437/characterization-of-the-transport-activity-of-sglt2-map17-the-renal-low-affinity-na-glucose-cotransporter
#14
Michael J Coady, Bernadette Wallendorff, Jean-Yves Lapointe
The cotransporter SGLT2 is responsible for 90% of the renal glucose reabsorption and we recently shown that MAP17 appears to work as a required beta subunit. We report in the present paper a detailed functional characterisation of human SGLT2 in co-expression with human MAP17 in Xenopus laevis oocytes. Addition of external glucose generates a large inward current in the presence of Na confirming an electrogenic transport mechanism. At a membrane potential of -50 mV, SGLT2 affinity constants for glucose and Na are 3...
June 7, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28587239/magnetic-lateral-flow-strip-for-the-detection-of-cocaine-in-urine-by-naked-eyes-and-smart-phone-camera
#15
Jing Wu, Mingling Dong, Cheng Zhang, Yu Wang, Mengxia Xie, Yiping Chen
Magnetic lateral flow strip (MLFS) based on magnetic bead (MB) and smart phone camera has been developed for quantitative detection of cocaine (CC) in urine samples. CC and CC-bovine serum albumin (CC-BSA) could competitively react with MB-antibody (MB-Ab) of CC on the surface of test line of MLFS. The color of MB-Ab conjugate on the test line relates to the concentration of target in the competition immunoassay format, which can be used as a visual signal. Furthermore, the color density of the MB-Ab conjugate can be transferred into digital signal (gray value) by a smart phone, which can be used as a quantitative signal...
June 5, 2017: Sensors
https://www.readbyqxmd.com/read/28585467/do-players-and-staff-sleep-more-during-the-pre-or-competitive-season-of-elite-rugby-league
#16
Johnpaul Caia, Tannath J Scott, Shona L Halson, Vincent G Kelly
This study establishes the sleep behaviour of players and staff during the pre- and competitive seasons of elite rugby league. For seven days during both the pre- and competitive seasons, seven rugby league players and nine full-time staff from one professional Australian rugby league club had their sleep monitored via wrist actigraphy and self-report sleep diaries. Two-way repeated measures analysis of variance determined differences between the pre- and competitive season in players and staff, with effect sizes (ES) used to interpret the practical magnitude of differences...
June 6, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28581692/examining-the-effects-of-rational-emotive-behavior-therapy-rebt-on-performance-outcomes-in-elite-paralympic-athletes
#17
Andrew G Wood, Jamie B Barker, Martin Turner, David Sheffield
Traditionally a psychotherapeutic intervention, Rational Emotive Behavior Therapy (REBT) is receiving increasing attention within the extant literature as an intervention to enhance the athletic performance and psychological wellbeing of competitive athletes. Whilst the benefits of REBT on psychological health are established, less is understood about the effects on athletic performance. The present study aimed to examine the immediate and maintained effects of REBT on physiological, psychological, and performance outcomes with elite Paralympic athletes...
June 5, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28573347/molalign-an-algorithm-for-aligning-multiple-small-molecules
#18
Shek Ling Chan
In small molecule drug discovery projects, the receptor structure is not always available. In such cases it is enormously useful to be able to align known ligands in the way they bind in the receptor. Here we shall present an algorithm for the alignment of multiple small molecule ligands. This algorithm takes pre-generated conformers as input, and proposes aligned assemblies of the ligands. The algorithm consists of two stages: the first stage is to perform alignments for each pair of ligands, the second stage makes use of the results from the first stage to build up multiple ligand alignment assemblies using a novel iterative procedure...
June 1, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28573268/atmospheric-gas-to-particle-conversion-why-npf-events-are-observed-in-megacities
#19
M Kulmala, V-M Kerminen, T Petäjä, A J Ding, L Wang
In terms of the global aerosol particle number load, atmospheric new particle formation (NPF) dominates over primary emissions. The key for quantifying the importance of atmospheric NPF is to understand how gas-to-particle conversion (GTP) takes place at sizes below a few nanometers in particle diameter in different environments, and how this nano-GTP affects the survival of small clusters into larger sizes. The survival probability of growing clusters is tied closely to the competition between their growth and scavenging by pre-existing aerosol particles, and the key parameter in this respect is the ratio between the condensation sink (CS) and the cluster growth rate (GR)...
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28567038/assessing-the-challenges-in-the-application-of-potential-probiotic-lactic-acid-bacteria-in-the-large-scale-fermentation-of-spanish-style-table-olives
#20
Francisco Rodríguez-Gómez, Verónica Romero-Gil, Francisco N Arroyo-López, Juan C Roldán-Reyes, Rosa Torres-Gallardo, Joaquín Bautista-Gallego, Pedro García-García, Antonio Garrido-Fernández
This work studies the inoculation conditions for allowing the survival/predominance of a potential probiotic strain (Lactobacillus pentosus TOMC-LAB2) when used as a starter culture in large-scale fermentations of green Spanish-style olives. The study was performed in two successive seasons (2011/2012 and 2012/2013), using about 150 tons of olives. Inoculation immediately after brining (to prevent wild initial microbiota growth) followed by re-inoculation 24 h later (to improve competitiveness) was essential for inoculum predominance...
2017: Frontiers in Microbiology
keyword
keyword
25914
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"